sodB

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superoxide dismutase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to sodB

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: oxidative stress response
Validation Method: whole-genome sequencing and susceptibility testing
Drug Classes: colistin
Organisms: Stenotrophomonas maltophilia
Papers: 1
Databases: Reslit

Papers1

Antimicrobial Peptide Exposure Selects for Resistant and Fit Stenotrophomonas maltophilia Mutants That Show Cross-Resistance to Antibiotics.

PMID 32999081 · 2020

The study identifies mutations in genes such as mraW, smd_0008, sspb, lptB, wbiI, ftsW, sodB, phoQ, and crp that confer resistance to antimicrobial peptides (AMPs) LL-37, PR-39, and colistin in Stenotrophomonas maltophilia. These mutations lead to cross-resistance to antibiotics and highlight the rapid development of AMP resistance in this opportunistic pathogen.

Gene Information

Gene Name: sodB
Allele: sodB
Encodes: superoxide dismutase
Source Database: Reslit
Mechanism: oxidative stress response
Confers Resistance To: colistin
Organisms Tested In: • Stenotrophomonas maltophilia
Validation Method: whole-genome sequencing and susceptibility testing
Sequence Accession: NCBI BioProject: PRJNA653015|NC_017671.1

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sodB

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sodB

Gene Information