Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
guanosine-3',5'-bispyrophosphate (ppGpp) 3'-pyrophosphohydrolase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| A138V | - | - | Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa | imipenem | Reslit | Candidate |
| S305P | - | - | Escherichia coli, Salmonella enterica | nitrofurantoin | Reslit | Candidate |
| G496S | - | - | Pseudomonas aeruginosa | ceftazidime | Reslit | Candidate |
A role for the stringent response in ciprofloxacin resistance in Pseudomonas aeruginosa.
The study identifies spoT and alaS mutations as key contributors to ciprofloxacin resistance in Pseudomonas aeruginosa, highlighting the role of ppGpp accumulation and translational defects in resistance mechanisms.
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