sspA

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small secreted protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to sspA

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: genomic analysis and TDtest
Drug Classes: levofloxacin, gentamicin
Organisms: Staphylococcus aureus, Escherichia coli
Geographic Location: Europe
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
E102K	-	-	Escherichia coli	gentamicin	Reslit	Candidate

Papers2

A Study of Antibiotic Tolerance to Levofloxacin and Rifampin in Staphylococcus aureus Isolates Causing Prosthetic Joint Infections: Clinical Relevance and Treatment Challenges.

PMID 41594048 · 2025

The study identified sspA and leuS as genes associated with increased levofloxacin tolerance in biofilm-forming S. aureus isolates, and prs and pgm as genes linked to rifampin tolerance in non-biofilm isolates.

Gene Information

Gene Name: sspA
Allele: sspA
Encodes: small secreted protein
Source Database: Reslit
Confers Resistance To: levofloxacin
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Europe
Validation Method: genomic analysis and TDtest
Sequence Accession: JAJHMK000000000|JAJHNB000000000|JAJHMI000000000|JAJHNN000000000|JAJHMB000000000|JAJHLP000000000|JAJHLR000000000|JAJHLS000000000|JAJHLQ000000000|JAJHMV000000000|JAJHNG000000000|JAJHNF000000000

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sspA

Mutations

Gene Information

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sspA

Mutations

Gene Information