ssrA

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small non-coding RNA involved in trans-translation

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UniProt

Protein entries specific to ssrA

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Validation StatusCandidate

Overview

Mechanism: Wild-type tmRNA is involved in trans-translation, and its absence leads to increased resistance to fluoroquinolones by reducing reactive oxygen species (ROS) production and preventing chromosome fragmentation.
Validation Method: Deletion of tmRNA in S. pneumoniae led to increased survival to fluoroquinolones, reduced ROS accumulation, and prevented chromosome fragmentation.
Drug Classes: fluoroquinolones
Organisms: Streptococcus pneumoniae
Papers: 1
Databases: Reslit

Papers1

Absence of tmRNA Has a Protective Effect against Fluoroquinolones in Streptococcus pneumoniae.

PMID 28119681 · 2016

The absence of tmRNA in Streptococcus pneumoniae increases resistance to fluoroquinolones by reducing ROS production and preventing chromosome fragmentation.

Gene Information

Gene Name: ssrA
Allele: ssrA
Encodes: small non-coding RNA involved in trans-translation
Source Database: Reslit
Mechanism: Wild-type tmRNA is involved in trans-translation, and its absence leads to increased resistance to fluoroquinolones by reducing reactive oxygen species (ROS) production and preventing chromosome fragmentation.
Confers Resistance To: fluoroquinolones
Organisms Tested In: • Streptococcus pneumoniae
Validation Method: Deletion of tmRNA in S. pneumoniae led to increased survival to fluoroquinolones, reduced ROS accumulation, and prevented chromosome fragmentation.

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ssrA

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ssrA

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