Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Succinyl-CoA synthetase
Overview
Genetic basis of persister tolerance to aminoglycosides in Escherichia coli.
The study identifies several genes involved in persister tolerance to gentamicin in Escherichia coli, including genes related to the electron transport chain, flagellar formation, and amino acid biosynthesis. Disruption of these genes affects gentamicin tolerance, highlighting their roles in persister formation.
Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics.
Mutations in the TCA cycle genes sucC and sucD increase susceptibility to β-lactam antibiotics in MRSA. The accumulation of succinyl-CoA in the sucC mutant leads to increased lysine succinylation, which impairs autolytic activity and increases β-lactam susceptibility.
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