Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
sulfonamide-resistant dihydropteroate synthase Sul1
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| C98G | - | - | Acinetobacter baumannii | trimethoprim sulfamethoxazole | Reslit | Candidate |
| D40N | - | - | Acinetobacter baumannii | trimethoprim sulfamethoxazole | Reslit | Candidate |
| F178G | - | reduces sulfa binding affinity | Escherichia coli, Salmonella enterica | sulfamethoxazole|sulfadiazine|sulfisoxazole | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Sul1 | Reference Gene CatalogResFinder DatabaseReslit | 970 | SULFAMETHOXAZOLE, SULFONAMIDE +12 | Shigella flexneri +305 | Australia, Czech Republic, Japan, Peru|Bolivia, Madrid, Spain, Bolivia, Poland, Italy, United Kingdom, Canada, Germany, Singapore|Colombia|Guyana|Brazil|Manaos, Europe|United States|Australia, Europe, China, Asia|Africa|Europe|South America|Global, Ireland, Tunisia, Global, Taiwan|North America|South America|Europe|Asia|Australia, Switzerland|Lausanne, Switzerland, United States, Thailand, Berlin, Germany, Denmark, Portugal, Madagascar, Metro-Manila, Philippines, China|Beijing, China, Brazil, Ankara, Turkey, Baltic Sea|Finland, USA|Brazil|United States, Kuwait, Recife, State of Pernambuco, Brazil, Iran, Brazil|China|Hong Kong|Indonesia|Israel|Nigeria|Peru|Singapore|Thailand|Vietnam, Zambia, Nebraska|United States, Jiangsu Province, Southeastern China, India, South West London, UK, Lower Saxony|Germany, Okinawa Prefecture, Japan, Nepal, Japan|Thailand|Canada|France|Spain|South Korea|United Kingdom|Croatia|Vietnam|global, Denmark|Taiwan|South Korea|Africa|Asia|Europe|North America|Canada|Norway|South Africa|United States, Germany|Denmark|Sweden|France|Italy, southwestern Nigeria, Netherlands, Malaysia, Europe|Italy, Nigeria, Europe|Portugal, Baltic Sea, Haiti, Nepal|Japan, United States|New York|Florida|Illinois|Gaza|Colombia|South America|Mediterranean region, Tanzania, South Korea, Norway, Egypt, Germany|France|Netherlands|Belgium, San Francisco|Seattle|Minnesota|Minneapolis|Sacramento|Dallas|Jackson, France, Delhi, India, Europe|Switzerland|Canada, Kenya, North Carolina, England, Ethiopia, Europe|seafood, Cambodia, Vietnam, Pakistan, Lake Geneva, Switzerland, Croatia, Alberta, Uganda, West Africa|Conakry, Guinea, Cameroon, UK|Latin America, Ghana, Scotland, Lake Geneva, Switzerland|Vidy Bay, Lake Geneva, global, Australia|India, Bangladesh|Pakistan|Nepal, Germany|Danube River, Gothenburg, Africa|Ghana|Kenya|Tanzania, Karachi, St. Louis, MO, USA, Argentina, La Paz, Bolivia|La Paz River basin, Australia|Denmark, Denmark|France|Poland|Italy|Hungary|Germany|Estonia|United States, China|Brazil|United Kingdom|Denmark, Manitoba, Canada, Chile, Egypt|Africa|Europe|Asia|Middle East|Indonesia|India|USA, Jordan, Ecuador, Spain, Pakistan|Denmark, North America|Washington, UK, Southeastern Brazil, Utah, Colombia, Northern Thailand, Amazon River|Kalamas River|Cam River|Cambridge|Amazon River Plume, Barcelona, Spain, South Africa, Denmark|Japan, Malawi, Greece, Tai'an, China, Italy|Far East countries, Lake Victoria, Tanzania, Portugal|Spain|France, H1 Hospital, Yellow Sea, northern Xinjiang, China|China, Philippines, Turkey, Shanghai, China, Korea, US, USA|Peru|Egypt|Cambodia|Kenya, Antarctic|Mediterranean, Thailand|Nepal, Europe|Poland, Europe|Netherlands, Denmark|Finland|Iceland|Lithuania|Netherlands|Spain, France|New Caledonia|La Réunion Island|French Guiana|French Polynesia|Guadeloupe|Madagascar|Tunisia|India, Bangladesh, Guadeloupe|French West Indies, Armenia|Georgia, Pacific region|Hawaii, Balochistan, Singapore, Dominican Republic, East Coast Peninsular Malaysia, Global|global|Turkey, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, Mexico, Tokyo, Japan|Japan, Europe|Spain|Hungary|Germany|France|Belgium|Poland|United Kingdom|Denmark, Europe|Poland|USA|China|France, Europe|Germany, India|Pakistan|Bangladesh|Philippines|Democratic Republic of the Congo, Europe|United States, Portugal|Porto, Sweden, Vietnam|Southeast Asia, California|Europe|North America|Republic of Congo, Romania|Spain, Slovakia, India|Malaysia|South China, sub-Saharan Africa|Burkina Faso|Ghana|Guinea-Bissau|Kenya|Senegal, US Metropolitan Areas, Brasília, Brazil, Europe|China|Pakistan|USA, Mexico|Mexico City, Henan province, China|Henan, China, Germany|United States|Canada|Singapore|Japan|Kenya|Nepal, Kelantan|Terengganu, Europe|broiler production pyramid, England|south-central England, England|Wales, Saudi Arabia, Africa|Gambia, Russia|Moscow, North Carolina|USA, Quebec|Ontario|France|Switzerland, Afghanistan, Victoria, Australia, Uganda|Kenya, India|United States, Caribbean, Russia, Europe|Greece, Finland|Eastern Finland, Mecklenburg-Western Pomerania, Milwaukee, Wisconsin, USA|USA, Taiwan, China|Guangdong Province, China, The Gambia, Japan|France|United Kingdom|North America|South America|Europe|Asia/Oceania|Africa, Romania|France, Europe|North America|Netherlands|Denmark|Pennsylvania|United States|France, Port Said Governorate|Mediterranean Sea, Europe|EU|China|Portugal|Germany, New South Wales, Australia, Sierra Leone, central Adriatic Sea|Croatia|Croatian marine environment, Australia|Melbourne, Australia, North America|Asia|Europe|Middle East|Africa, China|France|Australia|Germany|USA|Netherlands|Japan|Cambodia|Thailand|Vietnam|India|Pakistan|Chile|Czech Republic|Colombia|China (bigeye tuna), Hungary, Spain|Peru, South America, Europe|USA|Portugal|Germany|Australia|China|India|Pakistan|Sweden|Colorado, Ethiopia|Kenya, Zhejiang Province, China, UK|France, Hong Kong, Basque Country, northern Spain|Basque Country, New Zealand, Stellenbosch, South Africa, Abuja, Nigeria, Democratic Republic of Congo|Democratic Republic of the Congo, northwest China, Romania|Cluj County, North Western Romania, North Sea|Baltic Sea, South America|Chile, Switzerland, Turkiye, La Paz River basin, Bolivia|La Paz River basin, Burkina Faso, Iraq, Brazilian Amazon, Shandong Province, China, Portugal|Spain|Italy|Morocco, India|Iran|UK|China|Brazil|US|Australia, Zagreb, Croatia|Zagreb|Croatia, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, France|South Asia|Thailand|Malaysia|Belarus|Spain|Australia|Guatemala|India|Romania|Russia|USA, Ontario, Canada, Shijiazhuang, Hebei Province, Barcelona, Holtemme river, Saxony-Anhalt, Germany, Serbia, Anhui, China, swine manure, California, USA, Western Africa|Mali, Northwest, China|Northwest China, Maryland|California|New York|Pennsylvania, Finland, Ethiopia|USA|Israel|Turkey|United Kingdom|France|Belgium|Denmark|Czechia, Russia|Switzerland|Italy|USA|Norway|Spain|Ghana, Boeotia regional district, Greece, Wenzhou, China, Pakistan|Karachi, Pakistan, Spain|Asturias, Spain, West Texas, USA, Alexandria, Egypt, New Orleans metropolitan area, Shenzhen, China|China, Northern Italy, Moscow, Russia, Lake Michigan|United States|North America, Balochistan, Pakistan, Mozambique, Brazil|Belgium, Australia|South Australia, China|Germany|USA, South-Western districts of Uganda, Sharkia Governorate, Egypt|Egypt, Southern California, USA, Central Greece, South Africa|Spain|Netherlands|Switzerland|India|China|Germany|Russia|USA|Australia|Other countries, Central Adriatic|Central Adriatic Sea, Germany|Australia|Taiwan|USA|Canada|Denmark, USA, Danakil Depression, Afar Region, Ethiopia, Southeast Brazil, Europe|Asia|North America, Peruvian Amazon, South-Eastern Bangladesh|Bangladesh, Northern Spain, Brazil|Europe|United Kingdom|United States, Karachi, Pakistan, Asia|North America|Europe|Australia, Punjab, Pakistan, Zanzibar, Israel, Denmark|Finland|Germany, Jiangsu Province|China, Accra, Ghana|Ghana, Fiji, Virginia|Illinois, Bulgaria, Jos, Nigeria, United States|Pakistan|Bangladesh|Nigeria|Iraq|India, Netherlands|Kenya|United States|India|Tanzania, Edo State, Nigeria, China|United States|United Kingdom|Canada|Germany|Brazil|Australia, Bulgaria|Europe, Portugal|various regions, Asia|South America|North America|Europe|Africa, Pakistan|China|United States|United Kingdom|Canada|Australia|Spain|Denmark|UAE|Ethiopia|India|South Asia, Fujian Province, Southeast China|China, Vancouver, Canada, Romania, Uruguay, Europe|South America|Asia|North Africa, Armenia, Somali region, Ethiopia|Somali Region, Ethiopia, Europe|Midwestern United States, Türkiye, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, Peru, Europe|Africa|North America|South America|Asia|Oceania, Zimbabwe, Shanghai, China|China, Northwestern Transylvania, Romania, Europe|Asia|Africa, Calabria|Italy, mariculture areas, Iowa, United States, Republic of Korea, Indonesia|USA|China|Europe|Finland, Central Zone of Mexico|Mexico, Asia|North America|Australia|South America, Kano, Nigeria|Nigeria, Lebanon, United Arab Emirates, Western Balkans|Hungary, Mansoura, Egypt, Paraguay, Inner Mongolia|Inner Mongolia, China, North Carolina, USA, Argentina|Canada|Germany|United States, China|Europe|Americas|Asia|North Africa|Middle East, Paraguay|Northern Spain, Europe|Croatia, Guangdong, China, China|North America|Asia|Europe|Africa|Other, Pakistan|UK, Tianjin|Southern Karnataka, USA|China|Spain|Australia|Japan|Switzerland|Netherlands|Brazil|Taiwan|New Hampshire, USA|global, Atlanta, Australia|France|Bangladesh|United States, China|United Kingdom|Argentina|Europe|Americas|Asia|Africa|Australasia|Vietnam|Switzerland|Thailand|Mexico, India|Delhi NCR, Harare, Zimbabwe, Egypt|Tunisia|Middle East|North Africa, Europe|China, East Africa|Tanzania|Uganda, Asia|China, Algeria, Europe|Turkey, Middle East|Europe|Asia|South America|Peru|Egypt|Saudi Arabia|Denmark|Pakistan|Jordan|Iraq|Lebanon|China|Ghana, Southeastern Nigeria|Nigeria, Africa, Kazakhstan, northwest China|China | 1989, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AF188331.1 | AAG14405.1 |
| sul1 | Card DatabaseResFinder Database | 2 | SULFAMETHOXAZOLE | Vibrio fluvialis +1 | - | 2005 | JF969163.1 | AEJ33969.1 |
| sul | Reslit | 34 | sulfamethoxazole, trimethoprim sulfamethoxazole +2 | Klebsiella pneumoniae +28 | Iraq, Uganda, Brazil|United States|China|South Korea, Dublin, Denmark|Spain|France|Netherlands, Italy|Germany|Denmark|United Kingdom|Ireland|Poland|United States, North America|South America, China, Rwanda, Europe, Bangladesh, Europe|United Kingdom, Australia|USA|Romania|Austria, Kenya, Germany|Central Germany, Gulf Cooperation Council (GCC) region|Gulf Cooperation Council region, Global, Egypt, Mexico, USA|China|India|Thailand|Brazil|Hungary|South Africa|Egypt|Tunisia|Europe|Asia, South Asia|India|Bangladesh|Pakistan|Kenya, Sicily, South Africa, Zoba Anseba, Eritrea, Mayurbhanj, Odisha, India|India | 1988, 2012, 2014, 2015, 2017, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | NZ_CP007588.1|NZ_CP009223.1|NZ_CP009224.1|NZ_ANCA00000000.1|NZ_AEKT00000000.1|NZ_CAGH00000000.1|NZ_ATUU00000000.1|BBIK00000000.1|NC_015759.1|NZ_AKGG00000000.1|NZ_BAWR00000000.1|NZ_ACKU00000000.1|HE575133|HE575134|HE575135|HE575136|HE575137|HE575138|HE575139|HE575140|HE575141|HE575142|HE575143|HE575144|HE575145|HE575146|HE575147|HE575148|HE575149|HE575150|HE575151|HE575152|HE575153|HE575154|HE575155|HE575156|HE575157|HE575158|HE575159|HE575160|HE575161|HE575162|HE575163|HE575164|HE575165|HE575166|HE575167|HE575168|HE575169|HE575170|HE575171|HE575172|HE575173|HE575174|HE575175|HE575176|HE575177|HE575178|HE575179|HE575180|HE575181|HE575182 | - |
| sul 1 | Reslit | 40 | sulfamethoxazole, sulfonamides +1 | Salmonella enterica +27 | South Africa|Brazil, India, South Africa, northern Xinjiang, China|China, Colombia|USA, Bangladesh, United States|Virginia, Europe, Colombia, Vietnam, Guangdong Province, Edo state, Nigeria, Egypt, Eastern Cape province, South Africa|South Africa, Southeast Nigeria, West Bengal, India, Edo State, Nigeria, United States, Lake Michigan|United States|North America, Italy, Oregon, USA|Oregon, Germany, Spain, Iran, Shandong, China, Guadeloupe, Quebec|Shenzhen Bay, India|China|Brazil | 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | KX300038–KX300086|KY432753|KU573047–KU573052|KY924468–KY924470 | - |
| sul-1 | Reslit | 2 | trimethoprim sulfamethoxazole, sulfonamides | Salmonella enterica serovar Senftenberg +2 | India | 2019, 2024 | PRJNA483094 | - |
| Sul 1 | Reslit | 1 | sulfonamides | broiler chicken +2 | United States | 2021 | - | - |
| sul(1) | Reslit | 1 | trimethoprim sulfamethoxazole | Corynebacterium kroppenstedtii | China | 2023 | JYDD00000000 | - |
| Sul | Reslit | 3 | sulfonamides | Escherichia coli +5 | Shaanxi Province, Gaza Strip | 2023, 2024, 2025 | PRJNA984638 | - |
| sul1^ | Reslit | 1 | sulfonamides | Klebsiella oxytoca +1 | Uganda | 2024 | CP132017.1|CP132016.1 | - |
| sul -1 | Reslit | 1 | sulfamethoxazole | Escherichia coli | Bangladesh | 2024 | - | - |
| sul1/2 | Reslit | 1 | sulfonamides | Pseudomonas guariconensis | Tunisia | 2025 | NCBI:PRJNA1150136 | - |
| sul1-3 | Reslit | 1 | sulfonamides | Escherichia coli | China | 2025 | CP123266.1|CP176052.1|CP123269.1 | - |
In34, a complex In5 family class 1 integron containing orf513 and dfrA10.
The study identifies and characterizes the class 1 integron In34, which contains multiple antibiotic resistance genes including aadB, dfrA10, aphA1, catA1, blaTEM, and sul1. These genes confer resistance to various antibiotics such as gentamicin, kanamycin, tobramycin, trimethoprim, chloramphenicol, ampicillin, and sulfamethoxazole.
Integron-containing IncU R plasmids pRAS1 and pAr-32 from the fish pathogen Aeromonas salmonicida.
Integron-containing IncU R plasmids pRAS1 and pAr-32 from the fish pathogen Aeromonas salmonicida.
Evolution of antibiotic resistance in Salmonella enterica serovar typhimurium strains isolated in the Czech Republic between 1984 and 2002.
The study identifies the aadA21 gene, a novel variant of the aadA gene, and other resistance genes such as blaPSE-1, floR, sul1, and tetG in Salmonella enterica serovar Typhimurium strains from the Czech Republic between 1984 and 2002.
Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins.
Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid.
Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid.
Description of In116, the first blaCTX-M-2-containing complex class 1 integron found in Morganella morganii isolates from Buenos Aires, Argentina.
Description of In116, the first blaCTX-M-2-containing complex class 1 integron found in Morganella morganii isolates from Buenos Aires, Argentina.
The IncP-6 plasmid Rms149 consists of a small mobilizable backbone with multiple large insertions.
The study characterizes the IncP-6 plasmid Rms149, identifying several AMR genes including aac(3)-I, aadA5, intI1, qacEΔ1, and sul1, which confer resistance to gentamicin, streptomycin, spectinomycin, quaternary ammonium compounds, and sulfonamide, respectively.
VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid., Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil., Integron-containing IncU R plasmids pRAS1 and pAr-32 from the fish pathogen Aeromonas salmonicida., Detection and genetic characterisation of qnrB in hospital isolates of Klebsiella pneumoniae in Singapore., Detailed structure of integrons and transposons carried by large conjugative plasmids responsible for multidrug resistance in diverse genomic types of Salmonella enterica serovar Brandenburg., Urinary tract infections in a South American population: dynamic spread of class 1 integrons and multidrug resistance by homologous and site-specific recombination., Diversity and evolution of AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I., Emergence of DHA-1-producing Klebsiella spp. in the Parisian region: genetic organization of the ampC and ampR genes originating from Morganella morganii., Description of In116, the first blaCTX-M-2-containing complex class 1 integron found in Morganella morganii isolates from Buenos Aires, Argentina., Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid., Mobilization of qnrB2 and ISCR1 in plasmids., [Genetic environment of CTX-M-2 in Klebsiella pneumoniae isolates from hospitalized patients in Uruguay]., Comparative analysis of IncHI2 plasmids carrying blaCTX-M-2 or blaCTX-M-9 from Escherichia coli and Salmonella enterica strains isolated from poultry and humans., Occurrence and characteristics of class 1 and 2 integrons in Pseudomonas aeruginosa isolates from patients in southern China., Nucleotide sequence of the sulfonamide resistance gene from plasmid R46., The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129., Macrolide inactivation gene cluster mphA-mrx-mphR adjacent to a class 1 integron in Aeromonas hydrophila isolated from a diarrhoeic pig in Oklahoma., Invasion of E. coli biofilms by antibiotic resistance plasmids., The genomic island SGI1, containing the multiple antibiotic resistance region of Salmonella enterica serovar Typhimurium DT104 or variants of it, is widely distributed in other S. enterica serovars.
Macrolide inactivation gene cluster mphA-mrx-mphR adjacent to a class 1 integron in Aeromonas hydrophila isolated from a diarrhoeic pig in Oklahoma.
Macrolide inactivation gene cluster mphA-mrx-mphR adjacent to a class 1 integron in Aeromonas hydrophila isolated from a diarrhoeic pig in Oklahoma.
Emergence of DHA-1-producing Klebsiella spp. in the Parisian region: genetic organization of the ampC and ampR genes originating from Morganella morganii.
Emergence of DHA-1-producing Klebsiella spp. in the Parisian region: genetic organization of the ampC and ampR genes originating from Morganella morganii.
Organization of tn2610 containing two transposition modules.
The study characterizes the multidrug resistance transposon Tn2610, identifying several resistance genes including ereB, pse-1, aadA2, and sul1, which confer resistance to erythromycin, ampicillin, streptomycin, and sulfonamide, respectively.
Multidrug-resistant commensal Escherichia coli in children, Peru and Bolivia.
The study identified multiple multidrug-resistant commensal E. coli isolates in children from Peru and Bolivia, highlighting the prevalence of resistance genes such as blaTEM, tet(A), tet(B), dfrA8, sul1, sul2, and catI.
Spread of Escherichia coli Strains with High-Level Cefotaxime and Ceftazidime Resistance between the Community, Long-Term Care Facilities, and Hospital Institutions.
The study identifies the spread of Escherichia coli strains with high-level resistance to cefotaxime and ceftazidime, primarily due to the presence of extended-spectrum beta-lactamases (ESBLs) such as CTX-M-15, CTX-M-14, and CTX-M-32. Additionally, other resistance genes like tetA, dfrA14, dfrA17, sul1, sul2, aac(6')Ib, and aac(3)IIb were found to contribute to multidrug resistance.
Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil.
Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil.
Population structure and resistance genes in antibiotic-resistant bacteria from a remote community with minimal antibiotic exposure.
The study identified various acquired antibiotic resistance genes in commensal E. coli isolates from a remote community with minimal antibiotic exposure, including blaTEM, catI, cmlA6, tet(A), tet(B), dfrA1, dfrA7, dfrA8, dfrA17, sul1, sul2, aphA1, aadA1, aadA2, aadA5, aadB, and sat-1. These genes were found to be similar to those seen in antibiotic-exposed settings, indicating the dissemination of resistant bacteria and resistance genes from such environments.
Complete nucleotide sequence of the pCTX-M3 plasmid and its involvement in spread of the extended-spectrum beta-lactamase gene blaCTX-M-3.
The study characterizes the pCTX-M3 plasmid, which carries the blaCTX-M-3 gene, a extended-spectrum beta-lactamase, along with other resistance genes such as blaTEM-1, aadA2, aacC2, armA, dfrA12, and sul1, contributing to resistance against beta-lactams, aminoglycosides, and sulfonamides.
Comparative analysis of IncHI2 plasmids carrying blaCTX-M-2 or blaCTX-M-9 from Escherichia coli and Salmonella enterica strains isolated from poultry and humans.
Comparative analysis of IncHI2 plasmids carrying blaCTX-M-2 or blaCTX-M-9 from Escherichia coli and Salmonella enterica strains isolated from poultry and humans.
Detailed structure of integrons and transposons carried by large conjugative plasmids responsible for multidrug resistance in diverse genomic types of Salmonella enterica serovar Brandenburg.
Detailed structure of integrons and transposons carried by large conjugative plasmids responsible for multidrug resistance in diverse genomic types of Salmonella enterica serovar Brandenburg.
Different pathways to acquiring resistance genes illustrated by the recent evolution of IncW plasmids.
The study characterizes the acquisition of resistance genes via different pathways in IncW plasmids, highlighting the role of integrons and transposons in the spread of antibiotic resistance.
Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group.
The study identifies multiple beta-lactamases (blaOXA-58, blaOXA-20, blaOXA-66), an aminoglycoside acetyltransferase (aacA4), a sulfonamide resistance gene (sul1), and a quaternary ammonium compound efflux pump (qacEΔ1) in the multidrug-resistant Acinetobacter baumannii strain ACICU. Additionally, a gyrA mutation (Ser->Leu at position 83) was found to confer fluoroquinolone resistance.
Urinary tract infections in a South American population: dynamic spread of class 1 integrons and multidrug resistance by homologous and site-specific recombination.
Detection and genetic characterisation of qnrB in hospital isolates of Klebsiella pneumoniae in Singapore.
Occurrence and characteristics of class 1 and 2 integrons in Pseudomonas aeruginosa isolates from patients in southern China.
Occurrence and characteristics of class 1 and 2 integrons in Pseudomonas aeruginosa isolates from patients in southern China.
Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom.
The study identified the prevalence of sulfonamide resistance genes sul1, sul2, and sul3 in bacterial isolates from manured agricultural soils and pig slurry in the UK, highlighting their distribution and potential environmental impact.
Longitudinal characterization of resistant Escherichia coli in fecal deposits from cattle fed subtherapeutic levels of antimicrobials.
The study identified several AMR genes, including blaTEM1, tetA, tetB, tetC, sul1, and sul2, in Escherichia coli from cattle fecal deposits. These genes conferred resistance to ampicillin, tetracycline, and sulfonamides.
Antimicrobial resistances do not affect colonization parameters of intestinal E. coli in a small piglet group.
The study identified various AMR genes in commensal E. coli from pigs, including blaTEM, catA1, aph(3')-Ia, aadA, strA/strB, tet(A), tet(B), sul1, sul2, and sul3. These genes conferred resistance to antibiotics such as ampicillin, chloramphenicol, kanamycin, neomycin, streptomycin, spectinomycin, tetracycline, and sulfamethoxazole. However, the presence of these resistance genes did not provide a significant colonization advantage or disadvantage in the pig intestine.
High prevalence of multidrug-tolerant bacteria and associated antimicrobial resistance genes isolated from ornamental fish and their carriage water.
The study identified a high prevalence of multidrug-tolerant bacteria and various antimicrobial resistance genes in ornamental fish and their carriage water, highlighting the potential risk of resistance gene spread through the aquatic environment.
A predominant multidrug-resistant Salmonella enterica serovar Saintpaul clonal line in German turkey and related food products.
Diversity and evolution of AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I.
The study characterizes various AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I, identifying multiple AMR genes such as blaTEM-1, aacC1, aadA1, aacA4, dfrA1, catA1, sul1, and tetA, which confer resistance to beta-lactams, aminoglycosides, chloramphenicol, sulfonamides, and tetracyclines.
Diversity and evolution of AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I.
Diversity and evolution of AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I.
A multiplex real-time PCR assay targeting virulence and resistance genes in Salmonella enterica serotype Typhimurium.
The study identified the presence of bla TEM and sul1 genes in Salmonella enterica serotype Typhimurium strains, which confer resistance to beta-lactam and sulfonamide antibiotics, respectively.
Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing.
The study identified multiple AMR genes in a multidrug-resistant E. coli strain, including blaNDM-1, blaTEM-1, blaCTX-M-15, and others, along with chromosomal mutations in gyrA, parC, ompC, and ompF contributing to resistance.
Genomic analysis of the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06 widely spread in China.
The study identifies several AMR genes and mutations in the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06, including bla oxa-23, armA, and various efflux pumps, contributing to resistance against multiple antibiotics.
Emergence of a globally dominant IncHI1 plasmid type associated with multiple drug resistant typhoid.
The study identifies the emergence of a globally dominant IncHI1 plasmid type (PST6) associated with multiple drug-resistant typhoid. Key resistance genes include blaTEM-1, cat, dfrA7, sul1, sul2, strAB, tetA, tetD, and betU, which contribute to resistance against ampicillin, chloramphenicol, trimethoprim, sulfamethoxazole, streptomycin, tetracycline, and high salt environments.
Characterization of multidrug-resistant Escherichia coli isolates from animals presenting at a university veterinary hospital.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from animals, including bla TEM, bla CTX-M-2, bla CMY-2, strA-strB, aadA, aphA1, aadB, cat, floR, sul1, sul2, tet(A), and tet(B). These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, sulfonamides, and tetracyclines.
Phenotypic and genotypic characterization of Salmonella enterica recovered from poultry meat in Tunisia and identification of new genetic traits.
The study identified various AMR genes in Salmonella enterica isolates from poultry meat in Tunisia, including blaTEM, aadA1, aadA2, dfrA1, sul1, sul2, sul3, strA-strB, cmlA, and tet(A). These genes contribute to resistance against multiple antibiotics such as ampicillin, sulfonamides, streptomycin, trimethoprim, chloramphenicol, and tetracycline.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Stenotrophomonas maltophilia: Mechanisms, Clinical Implications, and Potential Therapeutic Strategies
The paper discusses the multidrug-resistant nature of Stenotrophomonas maltophilia, highlighting its resistance to various antibiotics including β-lactams, fluoroquinolones, aminoglycosides, and polymyxins. It emphasizes the challenges in treating infections caused by this pathogen due to its intrinsic resistance mechanisms and the need for alternative therapeutic approaches.
Deletion of TnAbaR23 results in both expected and unexpected antibiogram changes in a multidrug-resistant Acinetobacter baumannii strain.
The study shows that deletion of TnAbaR23 in Acinetobacter baumannii leads to increased susceptibility to sulfamethoxazole and gentamicin, highlighting the role of this transposon in multidrug resistance.
Impact of antibiotic treatments on the expression of the R plasmid tra genes and on the host innate immune activity during pRAS1 bearing Aeromonas hydrophila infection in zebrafish (Danio rerio).
The study characterizes the resistance genes dfr16, sul1, and tetA in the pRAS1 plasmid of Aeromonas hydrophila, showing their role in resistance to trimethoprim, sulfonamide, and tetracycline, respectively.
Increased levels of multiresistant bacteria and resistance genes after wastewater treatment and their dissemination into lake geneva, Switzerland.
The study identified the presence of sulfonamide resistance genes sul1 and sul2 in wastewater and lake samples, indicating the spread of multidrug-resistant bacteria after wastewater treatment.
Identification of acquired antimicrobial resistance genes.
The study presents ResFinder, a web-based tool for identifying acquired antimicrobial resistance genes in whole-genome data. It successfully identifies resistance genes with high accuracy and agrees with phenotypic testing. The tool detects various resistance genes across different bacterial species, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and others.
Characteristics of plasmids in multi-drug-resistant Enterobacteriaceae isolated during prospective surveillance of a newly opened hospital in Iraq.
The study identified various plasmid-borne antimicrobial resistance genes in multi-drug-resistant Enterobacteriaceae isolates from a newly opened hospital in Iraq, including aminoglycoside, beta-lactam, sulfamethoxazole/trime-thoprim, tetracycline, and chloramphenicol resistance genes.
The shared antibiotic resistome of soil bacteria and human pathogens.
The study identifies multiple antibiotic resistance genes in soil bacteria that are identical to those found in human pathogens, highlighting the exchange of resistance genes between environmental and clinical microbes.
Comparative sequence analysis of a multidrug-resistant plasmid from Aeromonas hydrophila.
The study identifies multiple AMR genes in the multidrug-resistant plasmid pR148 from Aeromonas hydrophila, including blaOXA-10, aadA1, sul1, catA2, and tetA, which confer resistance to beta-lactams, aminoglycosides, sulfonamides, chloramphenicol, and tetracyclines, respectively.
Frequent combination of antimicrobial multiresistance and extraintestinal pathogenicity in Escherichia coli isolates from urban rats (Rattus norvegicus) in Berlin, Germany.
The study identified multidrug-resistant Escherichia coli strains in urban rats, including an ESBL-producing strain (IMT20717) carrying bla CTX-M-9, bla TEM-1-like, sul2, strA, strB, aac(6′)-Ib-cr, and aadA. These strains exhibited resistance to multiple antimicrobial classes, including beta-lactams, aminoglycosides, and fluoroquinolones.
DNA sequence analysis of plasmids from multidrug resistant Salmonella enterica serotype Heidelberg isolates.
The study identified multiple antimicrobial resistance genes in plasmids from multidrug-resistant Salmonella enterica serotype Heidelberg isolates, including bla CMY, aadA, aadB, aphA, strA, strB, sul1, sul2, tetA, floR, cmlA, dfrA1, dfrA12, and aacC.
Sub-inhibitory concentrations of antibiotics and wastewater influencing biofilm formation and gene expression of multi-resistant Pseudomonas aeruginosa wastewater isolates.
The study identifies the sulfonamide resistance gene sul1 in multi-resistant Pseudomonas aeruginosa wastewater isolates, demonstrating its upregulation in response to sub-inhibitory concentrations of antibiotics and wastewater.
Comparative genomic analysis of rapid evolution of an extreme-drug-resistant Acinetobacter baumannii clone.
The study identifies multiple AMR genes and mutations in the EDR A. baumannii 53264 strain, including aac(6')-Iaf, aac(3)-Ia, aph(3')-Ia, aph(3')-Ic, strA/aph(3'')-Ib, blaOXA-23, blaTEM-1, sul1, sul3, and tet(B). Additionally, mutations in ampC, gyrB, parC, and qseC contribute to resistance against various antibiotics.
Commensal Enterobacteriaceae as reservoirs of extended-spectrum beta-lactamases, integrons, and sul genes in Portugal.
The study identifies blaCTX-M-14 and blaTEM-153 as extended-spectrum beta-lactamases in commensal Enterobacteriaceae in Portugal, along with sul1, sul2, and sul3 as sulfonamide resistance genes. These genes are part of mobile genetic elements such as integrons and plasmids, highlighting the role of commensal flora as a reservoir of clinically relevant antibiotic resistance genes.
Molecular characterization of multidrug-resistant extended-spectrum β-lactamase-producing Enterobacteriaceae isolated in Antananarivo, Madagascar.
The study identified bla CTX-M-15 and bla SHV-12 as the predominant ESBL genes in multidrug-resistant Enterobacteriaceae isolates in Antananarivo, along with other resistance genes such as aac(6')-Ib, tetA, sul1, sul2, qnrA, qnrB, and catB-3.
Who possesses drug resistance genes in the aquatic environment?: sulfamethoxazole (SMX) resistance genes among the bacterial community in water environment of Metro-Manila, Philippines.
The study identified sul1, sul2, and sul3 genes as the main sulfonamide resistance genes in the bacterial community of the aquatic environment in Metro-Manila, Philippines. Sul1 and sul2 were predominant in culturable bacteria, while sul3 was more prevalent in non-culturable marine bacteria.
Chronological Change of Resistance to β-Lactams in Salmonella enterica serovar Infantis Isolated from Broilers in Japan.
The study identified the emergence of Salmonella enterica serovar Infantis isolates carrying blaTEM-52, blaTEM-20, blaCTX-M-25, and blaCMY-2 genes, which confer resistance to extended-spectrum cephalosporins and other beta-lactams. Additionally, non-beta-lactam resistance genes such as aadA1, sul1, tet(A), and aphA1-Iab were prevalent.
Complete genome analysis of three Acinetobacter baumannii clinical isolates in China for insight into the diversification of drug resistance elements.
The study identifies multiple AMR genes and resistance islands in three multidrug-resistant Acinetobacter baumannii isolates, highlighting the role of genomic plasticity in the dissemination of resistance mechanisms.
Impact of manure fertilization on the abundance of antibiotic-resistant bacteria and frequency of detection of antibiotic resistance genes in soil and on vegetables at harvest.
The study identified several antibiotic resistance genes in soil and on vegetables, including genes conferring resistance to tetracycline, aminoglycosides, erythromycin, sulfamethoxazole, and beta-lactams. The presence of these genes was influenced by manure fertilization, with certain genes more frequently detected in manured soils.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
Characterization of class 1 integrons and antibiotic resistance genes in multidrug-resistant Salmonella enterica isolates from foodstuff and related sources.
The study identified several AMR genes, including aadA, sul1, sul2, tetA, blaTEM-1, and qacEAI, associated with resistance to streptomycin, sulfamethoxazole-trimethoprim, tetracycline, ampicillin, and quaternary ammonium compounds, respectively. A mutation in the gyrA gene (Ser83Phe) was linked to resistance to nalidixic acid and enrofloxacin.
Acquired genetic mechanisms of a multiresistant bacterium isolated from a treatment plant receiving wastewater from antibiotic production.
Antimicrobial resistance determinants in Acinetobacter baumannii isolates taken from military treatment facilities.
The study identified multiple antimicrobial resistance genes in Acinetobacter baumannii isolates from military treatment facilities, including bla OXA-51-like, bla OXA-23, bla GES-11, aac(6')-Ib, aacC1, aadB, aphA6, and others, highlighting the complex resistome of these isolates.
Characterization of antibiotic resistance in Salmonella enterica isolates determined from ready-to-eat (RTE) salad vegetables.
Four Salmonella enterica strains isolated from ready-to-eat salad vegetables exhibited resistance to sulfonamides, with sul1 and sul2 genes identified as the primary resistance mechanisms. The 55.0 kb plasmid of strain RTE-1 was found to encode these genes without involvement of integrons.
Diversity of plasmids encoding resistance and virulence functions in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variant 4,[5],12:i:- strains circulating in Europe.
The study identifies various AMR genes in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variant 4,[5],12:i:- strains, including aac(3)-IV, bla TEM-1, cmlA1, aadA1, aadA2, strA, sul1, sul2, sul3, tet(A), tet(B), and dfrA12, which confer resistance to multiple antibiotics.
Shifts in geographic distribution and antimicrobial resistance during a prolonged typhoid fever outbreak--Bundibugyo and Kasese Districts, Uganda, 2009-2011.
The study reports a high prevalence of multidrug-resistant (MDR) Salmonella Typhi isolates during a prolonged typhoid fever outbreak in Uganda, with 83% of 18 isolates being MDR. It also notes an increase in antimicrobial resistance compared to 2009 isolates.
Sulphonamide and trimethoprim resistance genes persist in sediments at Baltic Sea aquaculture farms but are not detected in the surrounding environment.
The study identified the persistence of sulphonamide resistance genes (sul1, sul2) and trimethoprim resistance gene (dfrA1) in sediments at Baltic Sea aquaculture farms, while these genes were not detected in the surrounding environment.
Comparative genomic analysis and virulence differences in closely related salmonella enterica serotype heidelberg isolates from humans, retail meats, and animals.
The study identified several AMR genes and mutations in Salmonella enterica serotype Heidelberg isolates, including bla, aac(6')-Ib, tet(M), qnrS1, and erm(B). Mutations in genes such as SEEHRA37_03221, SEEHRA37_24108, and others were associated with resistance traits.
Evaluation of Curetis Unyvero, a multiplex PCR-based testing system, for rapid detection of bacteria and antibiotic resistance and impact of the assay on management of severe nosocomial pneumonia.
The study evaluated the Curetis Unyvero assay for rapid detection of bacteria and antibiotic resistance markers in patients with severe nosocomial pneumonia. It identified several AMR genes, including ermB, bla OXA-51-like, sul1, int1, mecA, and bla CTX-M, which conferred resistance to various antibiotics.
Investigation of class 1 integrons in Klebsiella pneumoniae clinical and microbiota isolates belonging to different phylogenetic groups in Recife, State of Pernambuco.
The study identified the presence of class 1 integrons in clinical isolates of K. pneumoniae, particularly associated with resistance to sulfamethoxazole/trimethoprim. The sul1 gene within these integrons was linked to sulfonamide resistance.
Resistance determinants and mobile genetic elements of an NDM-1-encoding Klebsiella pneumoniae strain.
The study identifies multiple antibiotic resistance genes in the NDM-1-encoding Klebsiella pneumoniae strain, including eight beta-lactamase genes and various other resistance determinants, highlighting the complexity of its resistance profile.
Comparative genomic analysis of Klebsiella pneumonia (LCT-KP214) and a mutant strain (LCT-KP289) obtained after spaceflight.
The study identified the sul1 gene duplication as a mechanism for sulfamethoxazole resistance in the spaceflight mutant strain LCT-KP289. Additionally, the ampC, emrE, and ant genes were found to contribute to drug resistance in both strains.
Characterization of Escherichia coli virulence genes, pathotypes and antibiotic resistance properties in diarrheic calves in Iran.
The study identified several antibiotic resistance genes in E. coli isolates from diarrheic calves in Iran, including aadA1, sul1, aac[3]-IV, dfrA1, tetA, and tetB, which confer resistance to streptomycin, sulfonamide, gentamicin, trimethoprim, and tetracycline.
Characterization of microbiota composition and presence of selected antibiotic resistance genes in carriage water of ornamental fish.
The study identified several antibiotic resistance genes including sul1, tet(A), strA, aadA, cat, tet(G), and sul2 in the microbiota of ornamental fish carriage water. These genes were found to be prevalent and associated with various bacterial families.
Genomic signature of multidrug-resistant Salmonella enterica serovar typhi isolates related to a massive outbreak in Zambia between 2010 and 2012.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant Salmonella enterica serovar Typhi isolates from Zambia, including strA, strB, blaTEM-1, sul1, sul2, dfrA7, and catA1. Mutations in the gyrA gene were also associated with fluoroquinolone resistance.
Occurrence of Antimicrobial-Resistant Escherichia coli and Salmonella enterica in the Beef Cattle Production and Processing Continuum.
The study identified several AMR genes in E. coli and Salmonella, including beta-lactamase genes (blaCMY, blaCTX-M), sulfonamide resistance genes (sul1, sul2, sul3), and dihydrofolate reductase genes (dfrA1, dfrA5, dfrA7, dfrA12). These genes conferred resistance to various antibiotics such as ampicillin, ceftiofur, ceftriaxone, and trimethoprim-sulfamethoxazole.
Sulfonamide-resistant bacteria and their resistance genes in soils fertilized with manures from Jiangsu Province, Southeastern China.
The study identified the presence of sul1, sul2, and sul3 genes in sulfonamide-resistant bacteria from manured soils in Jiangsu Province, China, highlighting their role in sulfonamide resistance and the potential risk to public health.
Phylogenetic distribution and prevalence of genes encoding class I Integrons and CTX-M-15 extended-spectrum β-lactamases in Escherichia coli isolates from healthy humans in Chandigarh, India.
The study identifies the presence of class 1 integrons and bla CTX-M-15 genes in commensal E. coli isolates from healthy individuals in Chandigarh, India. It also detects several gene cassettes conferring resistance to trimethoprim, streptomycin, spectinomycin, streptothricin, chloramphenicol, tetracycline, and sulfonamides.
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.
The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.
Antimicrobial Resistance Mechanisms in Salmonella and Other Bacteria
The paper discusses multidrug efflux pumps from various bacterial food pathogens including Enterobacteriaceae, Vibrio cholerae, and Staphylococcus aureus, highlighting their role in multidrug resistance.
Transferable antibiotic resistance plasmids from biogas plant digestates often belong to the IncP-1ε subgroup.
The study identified IncP-1ε plasmids carrying genes such as tet(A), sul1, qacEΔ1, intI1, and aadA1, which confer resistance to tetracycline, sulfadiazine, quaternary ammonium compounds, and streptomycin.
Resistance phenotypes and genotypes among multiple-antimicrobial-resistant Salmonella enterica subspecies enterica serovar Choleraesuis strains isolated between 2008 and 2012 from slaughter pigs in Okinawa Prefecture, Japan.
The study identified multiple antimicrobial resistance genes in Salmonella enterica subspecies enterica serovar Choleraesuis strains, including blaTEM, strA, strB, aadA1, aadA2, aphA1, aacC2, tetB, sul1, sul2, dhfrXII, and dhfrXIII. Additionally, mutations in the QRDRs of gyrA and parC were associated with quinolone resistance.
Draft Genome Sequence of a New Delhi Metallo-β-Lactamase-5 (NDM-5)-Producing Multidrug-Resistant Escherichia coli Isolate.
The study reports the identification of blaNDM-5 along with multiple other antibiotic resistance genes in a multidrug-resistant E. coli isolate, highlighting the complex resistance profile of the strain.
Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648.
The study identified bla CTX-M-15, aac (3)-IIa, aadA1, aadA2, aadA5, qnrB4, qnrS1, aac (6')-Ib-cr, bla OXA-1, bla TEM-1B, bla SHV-12, bla CMY-42, bla DHA-1, mphA, ermB, catA1, catB3, sul1, sul2, dfrA12, dfrA17, dfrA1, dfrA5, tetA, tetB, and tetD as key AMR genes in ESBL-producing E. coli isolates in Nepal, highlighting the prevalence of multidrug resistance.
Occurrence of bla CTX-M-1, qnrB1 and virulence genes in avian ESBL-producing Escherichia coli isolates from Tunisia.
The study identified blaCTX-M-1, qnrB1, tetA, tetB, sul1, sul2, and sul3 genes in avian ESBL-producing E. coli isolates from Tunisia, highlighting their role in resistance to beta-lactams, quinolones, and sulfonamides.
Point-of-care multiplex PCR promises short turnaround times for microbial testing in hospital-acquired pneumonia--an observational pilot study in critical ill patients.
The study evaluated the performance of a point-of-care multiplex PCR system for detecting pathogens and antibiotic resistance markers in hospital-acquired pneumonia. The system showed significantly shorter turnaround times compared to conventional microbiological diagnostics, although its performance was limited by frequent test failures and non-concordant results.
Insight into the mobilome of Aeromonas strains.
The study characterizes various antibiotic resistance genes (ARG) in Aeromonas strains, highlighting the presence of beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others. These genes are often located on plasmids and contribute to multidrug resistance.
Mapping the Evolution of Hypervirulent Klebsiella pneumoniae.
The study identifies antibiotic resistance genes in hypervirulent Klebsiella pneumoniae isolates, highlighting the presence of SHV beta-lactamase and additional resistance genes in one isolate, CAS813, which exhibits resistance to multiple antibiotics.
Antimicrobial Susceptibility of Bordetella bronchiseptica Isolates from Swine and Companion Animals and Detection of Resistance Genes.
The study identified several AMR genes in Bordetella bronchiseptica isolates, including blaBOR-1, blaOXA, strA, strB, sul1, sul2, dfrA7, and tet(A). These genes confer resistance to various antibiotics such as ampicillin, streptomycin, trimethoprim/sulfamethoxazole, and tetracycline.
Housefly Larva Vermicomposting Efficiently Attenuates Antibiotic Resistance Genes in Swine Manure, with Concomitant Bacterial Population Changes.
The study found that housefly larva vermicomposting significantly reduces the abundance of tetracycline resistance genes (tet(M), tet(O), tet(Q), tet(W)) and increases the abundance of sulfonamide resistance genes (sul1, sul2) in swine manure. It also observed changes in the bacterial community structure, with a significant decrease in the diversity and richness of bacteria.
Molecular characterization of selected multidrug resistant Pseudomonas from water distribution systems in southwestern Nigeria.
The study identified multiple antibiotic resistance genes in multidrug-resistant Pseudomonas isolates from water distribution systems in southwestern Nigeria, including tet(A), sul1, blaTEM, aph(3")c, and ant(3")b.
Abundance of Antibiotic Resistance Genes in Bacteriophage following Soil Fertilization with Dairy Manure or Municipal Biosolids, and Evidence for Potential Transduction.
The study identified antibiotic resistance genes (ARGs) in bacteriophage and bacterial fractions of agricultural soil, demonstrating that soilborne bacteriophage represents a reservoir of antibiotic resistance and that bacteriophage could play a significant role in the horizontal transfer of resistance genes in agricultural soil microbiomes.
Comparative genomics of non-pseudomonal bacterial species colonising paediatric cystic fibrosis patients.
The study analyzed non-pseudomonal bacterial species from pediatric cystic fibrosis patients, identifying several AMR genes and mutations. Key findings include the presence of beta-lactamase genes (blaZ, blaI, blaRI) in Staphylococcus aureus, fosfomycin resistance gene fosB, fusidic acid resistance gene fusC, and efflux pumps smeZ, smeJ, and smeK in Stenotrophomonas maltophilia. Additionally, Enterobacter cloacae isolates carried resistance genes qacE delta 1, sul1, and dfrA5.
Draft genome sequence of blaVeb-1, blaoxa-10 producing multi-drug resistant (MDR) Pseudomonas aeruginosa strain VRFPA09 recovered from bloodstream infection.
The study reports the draft genome sequence of MDR Pseudomonas aeruginosa strain VRFPA09, identifying several AMR genes including blaVeb-1, blaOXA-10, aadA1, aph(3')Iib, Sul1, CatB7, TetG, dfrB5, and fosA, which contribute to resistance against various antibiotics.
The controversial nature of the Weissella genus: technological and functional aspects versus whole genome analysis-based pathogenic potential for their application in food and health.
The study identified several antibiotic resistance genes in Weissella species, including fosB, mdt-fosB, mrp, vanZ, sul, tet, and drrC, which confer resistance to fosfomycin, methicillin, teicoplanin, sulfonamide, tetracycline, and daunorubicin respectively.
Nucleotide sequence of the sulfonamide resistance gene from plasmid R46.
Nucleotide sequence of the sulfonamide resistance gene from plasmid R46.
Evolution of AbGRI2-0, the Progenitor of the AbGRI2 Resistance Island in Global Clone 2 of Acinetobacter baumannii.
The study identifies several AMR genes in the A320 strain of Acinetobacter baumannii, including blaTEM, aacC1, aadA1, sul1, catA1, and aphA1b, which confer resistance to various antibiotics.
Emergence of a Clonal Lineage of Multidrug-Resistant ESBL-Producing Salmonella Infantis Transmitted from Broilers and Broiler Meat to Humans in Italy between 2011 and 2014.
The study identifies the emergence of a multidrug-resistant ESBL-producing Salmonella Infantis clone transmitting from broilers and broiler meat to humans in Italy, harboring the bla CTX-M-1 and bla CTX-M-65 genes, along with resistance genes tet(A), sul1, dfrA1, and dfrA14.
The Complete Sequence and Comparative Analysis of a Multidrug-Resistance and Virulence Multireplicon IncFII Plasmid pEC302/04 from an Extraintestinal Pathogenic Escherichia coli EC302/04 Indicate Extensive Diversity of IncFII Plasmids.
The study characterizes the multidrug-resistant plasmid pEC302/04 from an extraintestinal pathogenic E. coli strain, identifying several AMR genes including blaTEM-1, aadA1, aadB, cmlA, and sul1, which confer resistance to various antibiotics.
Draft Genome Sequence of Proteus mirabilis NO-051/03, Representative of a Multidrug-Resistant Clone Spreading in Europe and Expressing the CMY-16 AmpC-Type β-Lactamase.
The draft genome sequence of Proteus mirabilis NO-051/03 reveals the presence of multiple acquired resistance genes, including blaCMY-16 and blaTEM-1b, which confer resistance to β-lactams, as well as genes for resistance to aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, and sulfonamides. Additionally, mutations in gyrA, gyrB, and parC contribute to fluoroquinolone resistance.
Prevalence of virulence and antimicrobial resistance genes in Salmonella spp. isolated from commercial chickens and human clinical isolates from South Africa and Brazil.
The study identified the presence of virulence and antimicrobial resistance genes in Salmonella isolates from commercial chickens and human clinical samples in South Africa and Brazil. Key resistance genes included pse-1 (ampicillin), ant (3")-la (gentamicin), tet A and tet B (tetracycline), and sul 1 and sul 2 (sulfamethoxazole).
SSTAR, a Stand-Alone Easy-To-Use Antimicrobial Resistance Gene Predictor.
The study presents SSTAR, a software tool for identifying antimicrobial resistance (AR) genes from whole-genome sequencing data. It detects known AR genes and potential new variants, including truncated forms. The tool was applied to analyze resistance genes in Klebsiella pneumoniae ST437 and Escherichia coli ST44, revealing various beta-lactamases, aminoglycoside resistance genes, and porin mutations contributing to resistance.
Whole-Genome Sequencing for Detecting Antimicrobial Resistance in Nontyphoidal Salmonella.
The study identified 65 unique resistance genes in nontyphoidal Salmonella, including bla CTX-M1 and bla SHV2a, which were first reported in retail meat isolates in the United States. The research highlights the effectiveness of whole-genome sequencing in detecting antimicrobial resistance genes and correlating them with phenotypic resistance.
Identification of an NDM-5-producing Escherichia coli Sequence Type 167 in a Neonatal Patient in China.
The study identifies NDM-5-producing Escherichia coli ST167 in a neonatal patient in China, highlighting the spread of carbapenem resistance through the bla NDM-5 gene and other resistance mechanisms.
The Bacterial Mobile Resistome Transfer Network Connecting the Animal and Human Microbiomes.
The study identifies mobile antibiotic resistance genes (ARGs) in bacterial genomes and explores their transfer networks between animal and human microbiomes, highlighting the role of phylogeny and ecology in shaping the mobile resistome.
Corrected Genome Annotations Reveal Gene Loss and Antibiotic Resistance as Drivers in the Fitness Evolution of Salmonella enterica Serovar Typhimurium.
The study identifies antibiotic resistance genes and genomic islands in Salmonella enterica serovar Typhimurium, highlighting the role of horizontal gene transfer in the acquisition of multidrug resistance and fitness-related genes.
Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio fluvialis Isolated from Diarrheal Samples.
The study identifies the bla NDM-1 gene as a major cause of carbapenem resistance in Vibrio fluvialis isolates from Kolkata, India. Several additional resistance genes, including aadA1, aadB, aac(6')-Ib-cr, sul1, sul3, floR, bla OXA-1, bla OXA-7, bla OXA-9, bla TEM-9, bla CTX-M-3, strA, and tetB, were also characterized.
Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.
The study identified multiple S. Typhi genotypes in Nigeria, with a focus on antimicrobial resistance genes and plasmids. Key resistance genes included blaTEM-1, catA1, tetB, dfrA15, sul1, sul2, strAB, aad, and qnrS, primarily associated with the IncHI1 plasmid. Quinolone resistance was linked to gyrA mutations S83Y and S83F.
Architecture of Class 1, 2, and 3 Integrons from Gram Negative Bacteria Recovered among Fruits and Vegetables.
The study identified several AMR genes in Gram-negative bacteria from fresh produce, including mcr-1, qnrA1, blaGES-11, mphA, and oqxAB, highlighting the presence of mobile genetic elements and clinically relevant resistance genes.
Isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from cats.
The study identifies the blaIMP-4 gene in Salmonella enterica Typhimurium from cats, which confers resistance to carbapenems. The gene is part of a multidrug-resistant IncHI2 plasmid carrying various resistance genes.
Evaluating the mobility potential of antibiotic resistance genes in environmental resistomes without metagenomics.
The study identifies and characterizes the mobility potential of sul1 and tetM antibiotic resistance genes in environmental samples using a novel method involving Inverse PCR and long read sequencing.
Antimicrobial Susceptibility of Autochthonous Aquatic Vibrio cholerae in Haiti.
The study identified several AMR genes in environmental isolates of Vibrio cholerae non-O1/non-O139 in Haiti, including strA, strB, sul1, sul2, ermA, ermB, and mefA, which confer resistance to streptomycin, sulfonamide, and erythromycin.
Comparative Genome Analysis of Extended-Spectrum-β-Lactamase-Producing Escherichia coli Sequence Type 131 Strains from Nepal and Japan.
The study identified multiple AMR genes, including blaCTX-M-15, blaOXA-1, aac(6')-Ib-cr, tet(A), mphA, strA, strB, aadA5, sul1, sul2, dfrA12, dfrA17, catA1, and catB3, in ESBL-producing E. coli ST131 isolates from Nepal and Japan. These genes conferred resistance to various antibiotics, including β-lactams, aminoglycosides, tetracyclines, macrolides, sulfonamides, and chloramphenicol.
Surveillance of Dihydropteroate Synthase Genes in Stenotrophomonas maltophilia by LAMP: Implications for Infection Control and Initial Therapy.
The study developed LAMP assays for the detection of sul1 and sul2 genes in Stenotrophomonas maltophilia, which are responsible for sulfamethoxazole resistance. The LAMP assays showed high sensitivity and specificity, and the study found that sul1 and sul2 were prevalent in sulfamethoxazole-resistant strains.
Isolation, Antimicrobial Susceptibility Profile and Detection of Sul1, blaTEM, and blaSHV in Amoxicillin-Clavulanate-Resistant Bacteria Isolated From Retail Sausages in Kampar, Malaysia.
The study identified blaTEM, blaSHV, and Sul1 as the primary resistance mechanisms in amoxicillin-clavulanate-resistant bacteria isolated from retail sausages in Malaysia.
Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms.
The study identifies multiple carbapenemase genes (bla KPC-2, bla KPC-3, bla KPC-4, and bla NDM-1) and other resistance genes (such as qnrB19, qnrB2, qnrS1, bla TEM-1A, bla TEM-1B, bla OXA-9, bla SHV-12, aadA2, aac(6')-Ib, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ic, strA, strB, sul1, sul2, dfrA14, dfrA18, mph(A), catB3, arr-3, and tet(D)) in carbapenem-resistant Enterobacter spp. These genes are primarily located on plasmids and contribute to multidrug resistance.
Characterisation of Commensal Escherichia coli Isolated from Apparently Healthy Cattle and Their Attendants in Tanzania.
The study identified several antimicrobial resistance genes in commensal E. coli isolates from cattle and their attendants in Tanzania, including blaTEM-1B, sul1, sul2, and tet(A). These genes conferred resistance to beta-lactams, sulfamethoxazole-trimethoprim, and tetracycline, respectively.
Whole-Genome Analysis of Antimicrobial-Resistant and Extraintestinal Pathogenic Escherichia coli in River Water.
The study identified numerous antimicrobial resistance genes in Escherichia coli isolates from river water, highlighting the presence of multidrug-resistant and extraintestinal pathogenic strains. Key resistance genes included blaTEM-1, aac(3)-IId, qnrB7, and others.
Intraclonal Genome Stability of the Metallo-β-lactamase SPM-1-producing Pseudomonas aeruginosa ST277, an Endemic Clone Disseminated in Brazilian Hospitals.
The study identifies the blaSPM-1 gene as a key factor in carbapenem resistance in Pseudomonas aeruginosa ST277 isolates, along with other resistance genes in genomic islands.
Draft Genome Sequences of Pandrug-Resistant Serratia marcescens Clinical Isolates Harboring blaNDM-1.
The study reports the draft genome sequences of two pandrug-resistant Serratia marcescens clinical isolates carrying multiple antibiotic resistance genes, including blaNDM-1, blaSHV-12, blaTEM-1B, blaCMY-6, sul1, sul2, rmtC, aacA4, aac(6')Ib-c, strA, strB, dfrA18, qnrA1, catA2, aac(6')-Ic, tet(41), and ampC.
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
Marine Bivalve Mollusks As Possible Indicators of Multidrug-Resistant Escherichia coli and Other Species of the Enterobacteriaceae Family.
The study identified multiple AMR genes in E. coli isolates from marine bivalves, including bla TEM-1, bla CTX-M-14, bla CTX-M-15, and various aminoglycoside, trimethoprim, sulfonamide, tetracycline, chloramphenicol, quinolone, and macrolide resistance genes. These findings highlight the potential risk of MDR Enterobacteriaceae in marine environments.
A putative multi-replicon plasmid co-harboring beta-lactamase genes blaKPC-2, blaCTX-M-14 and blaTEM-1 and trimethoprim resistance gene dfrA25 from a Klebsiella pneumoniae sequence type (ST) 11 strain in China.
The study identifies a novel multi-replicon plasmid pHS091147 carrying multiple resistance genes, including blaKPC-2, blaCTX-M-14, blaTEM-1, dfrA25, and sul1, which confer resistance to various antibiotics such as carbapenems, cephalosporins, and trimethoprim.
Epidemiological, molecular characterization and antibiotic resistance of Salmonella enterica serovars isolated from chicken farms in Egypt.
The study identified various AMR genes in Salmonella enterica serovars isolated from chicken farms in Egypt, including blaTEM, aadA2, floR, cat1, sul1, sul3, tetC, tetA, and intI, which confer resistance to ampicillin, streptomycin, chloramphenicol, sulfamethoxazole, tetracycline, and multiple antibiotics.
Carbapenem-resistance and pathogenicity of bovine Acinetobacter indicus-like isolates.
The study identifies carbapenem-resistant Acinetobacter indicus-like isolates from cattle carrying the blaOXA-23 gene, along with various other AMR genes such as aac(3)-IIa, strA/B, aph(3')-Ic, sul2, floR, tet(A), tet(Y), aadA1, aadB, sul1, and tet(X).
Identification of a novel sequence type of Escherichia coli as the causative agent of pyelonephritis and bloodstream infection.
The study identifies a novel sequence type of Escherichia coli (ST-458) responsible for pyelonephritis and bloodstream infection, carrying multiple antibiotic resistance genes and mutations associated with resistance to fluoroquinolones, aminoglycosides, sulfonamides, and beta-lactams.
Genomic Analysis of Factors Associated with Low Prevalence of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli Sequence Type 95 Strains.
The study identifies several AMR genes in ST95 E. coli strains, including blaTEM-1, blaCTX-M14, aadA1, aadA2, aadA5, aac3, strA, strB, tetA, tetB, tetD, sul1, sul2, dfrA5, dfrA12, dfrA17, mphA, and catA1, which confer resistance to various antibiotics such as ampicillin, cephalothin, streptomycin, tetracycline, sulfamethoxazole, trimethoprim, azithromycin, and chloramphenicol.
Multidrug Resistance Salmonella Genomic Island 1 in a Morganella morganii subsp. morganii Human Clinical Isolate from France.
The study reports the first identification of Salmonella genomic island 1 (SGI1) in a multidrug-resistant clinical isolate of Morganella morganii subsp. morganii, carrying resistance genes dfrA15, floR, tetA(G), blaCARB-2, and sul1, conferring resistance to trimethoprim, chloramphenicol, tetracycline, ticarcillin, and sulfonamides, respectively.
Distribution of Integrons and Phylogenetic Groups among Enteropathogenic Escherichia coli Isolates from Children <5 Years of Age in Delhi, India.
The study identified various AMR genes including dfrA1, dfrA7, dfrA12, aadA1, aadA2, sul1, tetA, aacC1, TEM, SHV, CTX-M, OXA, NDM-1, IMP, VIM, ACT, DHA, and CMY in E. coli isolates from children in Delhi, India. These genes were associated with resistance to multiple antibiotics such as trimethoprim, streptomycin, sulfonamides, tetracycline, gentamicin, and various beta-lactams.
Biofilm Formation Potential of Heat-Resistant Escherichia coli Dairy Isolates and the Complete Genome of Multidrug-Resistant, Heat-Resistant Strain FAM21845.
The study identified multiple antimicrobial resistance genes in the multidrug-resistant, heat-resistant E. coli strain FAM21845, including beta-lactamase blaTEM-1, aminoglycoside resistance genes strA, strB, aadA1, aph(3')-Ic, aph(4)-Ia, aac(3)-IVa, sulfonamide resistance gene sul1, trimethoprim resistance gene dfrA1, tetracycline resistance gene tet(B), disinfectant resistance gene qacEΔ1, and biofilm-related genes mrkABCDF. Additionally, the strain carried genes for resistance to arsenic, silver, and copper.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
Genomic Analysis of Multidrug-Resistant Escherichia coli from North Carolina Community Hospitals: Ongoing Circulation of CTX-M-Producing ST131-H30Rx and ST131-H30R1 Strains.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from North Carolina community hospitals, including bla CTX-M-15, bla CTX-M-14, aac(6′)-Ib-cr, qnrS1, and mutations in gyrA, parC, and parE that confer resistance to various antibiotics.
Characterization of a blaNDM‑1‑harboring plasmid from a Salmonella enterica clinical isolate in China.
The study characterizes a blaNDM-1-harboring plasmid from a Salmonella enterica clinical isolate in China, identifying multiple resistance genes including blaNDM-1, blaCMY-6, dfrA12, aadA2, rmtC, qacEΔ1, sul1, and bleMBL.
Characterization of a Large Antibiotic Resistance Plasmid Found in Enteropathogenic Escherichia coli Strain B171 and Its Relatedness to Plasmids of Diverse E. coli and Shigella Strains.
The study characterized a large antibiotic resistance plasmid, pB171_90, from EPEC strain B171, identifying several AMR genes including aadA1, sul1, tetA, tetR, qacE Δ 1, csi, hha, and traI.
Systematic longitudinal survey of invasive Escherichia coli in England demonstrates a stable population structure only transiently disturbed by the emergence of ST131.
The study identified various antibiotic resistance genes, including bla CTX-M-15, aac(6')-Ib, bla OXA-1, bla TEM-1, dfrA, mphA, sul1, and tetA, in E. coli isolates, highlighting the multidrug-resistant nature of ST131 and the presence of distinct plasmid profiles contributing to resistance.
Genomic characterization of novel IncFII-type multidrug resistant plasmids p0716-KPC and p12181-KPC from Klebsiella pneumoniae.
The study characterizes two novel IncFII-type multidrug-resistant plasmids, p0716-KPC and p12181-KPC, from Klebsiella pneumoniae. These plasmids carry multiple resistance genes, including blaKPC-2, mph(A), strAB, aacC2, qacEΔ1, sul1, sul2, dfrA25, aphA1a, and blaTEM-1, contributing to resistance against various antibiotics.
Molecular determination of antimicrobial resistance in Escherichia coli isolated from raw meat in Addis Ababa and Bishoftu, Ethiopia.
The study identified several AMR genes in E. coli isolates from raw meat, including blaCMY, tet(A), and sul1, which confer resistance to beta-lactams, tetracyclines, and sulfonamides, respectively.
Serotyping, antibiotic susceptibility, and virulence genes screening of Escherichia coli isolates obtained from diarrheic buffalo calves in Egyptian farms.
The study identified several antibiotic resistance genes in E. coli isolates from diarrheic buffalo calves in Egypt, including aadB, blaTEM, and Sul1, which confer resistance to aminoglycosides, beta-lactams, and sulfonamides, respectively.
Resistance to Antibiotics, Biocides, Preservatives and Metals in Bacteria Isolated from Seafoods: Co-Selection of Strains Resistant or Tolerant to Different Classes of Compounds.
The study identified multiple antibiotic resistance genes, including sul1, sul2, floR, aadA1, aac(6')-Ib, blaTEM, blaCTX-M, blaPSE, blaNDM-1, qacEΔ1, pcoA/copA, chrB, and pcoR, in bacterial isolates from seafood. These genes conferred resistance to sulfonamides, phenicols, aminoglycosides, beta-lactams, and heavy metals.
The clinical and microbiological characteristics of enteric fever in Cambodia, 2008-2015.
The study identified various AMR genes and mutations in Salmonella Typhi and Salmonella Paratyphi A isolates from Cambodia, including beta-lactamase (blaTEM-1B), chloramphenicol acetyltransferase (catA1), sulfonamide resistance proteins (sul1, sul2), dihydrofolate reductase (dfrA7), tetracycline resistance protein (tet(B)), and streptomycin resistance protein (strAB). Additionally, mutations in the gyrA and gyrB genes were associated with decreased ciprofloxacin susceptibility.
Rapid Nanopore Sequencing of Plasmids and Resistance Gene Detection in Clinical Isolates.
The study demonstrates the feasibility of rapid nanopore sequencing for detecting plasmid-borne antimicrobial resistance (AMR) genes in clinical isolates. It identifies several AMR genes, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, tetracycline resistance genes, macrolide resistance genes, and phenicol resistance genes, in both Escherichia coli and Klebsiella pneumoniae isolates.
Extensively Drug-Resistant Escherichia coli Sequence Type 1642 Carrying an IncX3 Plasmid Containing the blaKPC-2 Gene Associated with Transposon Tn4401a.
The study identifies several AMR genes in an extensively drug-resistant E. coli ST1642 isolate, including blaKPC-2, blaSHV-11, blaTEM-1, aadA5, strA, strB, aac(3)-IId, mph(A), sul1, sul2, tet(B), dfrA17, and qnrS1, which contribute to resistance against multiple antibiotics.
VIM-1 carbapenemase-producing Escherichia coli isolated from retail seafood, Germany 2016.
The study identifies a VIM-1 carbapenemase-producing E. coli isolate from retail seafood in Germany, highlighting the presence of multiple resistance genes including blaVIM-1, aacA4, aadA1, aph(3')-XV, catB2, qnrS1, blaSHV-12, blaACC-1, strA-like, strB-like, dfrA14-like, mph(A), sul1, and sul2.
Plant Growth, Antibiotic Uptake, and Prevalence of Antibiotic Resistance in an Endophytic System of Pakchoi under Antibiotic Exposure.
The study identified the presence of tetX, blaCTX-M, sul1, and sul2 genes in the endophytic system of pakchoi under antibiotic exposure, indicating the development of antibiotic resistance in response to tetracycline, cephalexin, and sulfamethoxazole.
Exploring the Genome and Phenotype of Multi-Drug Resistant Klebsiella pneumoniae of Clinical Origin.
The study identified multiple antimicrobial resistance genes in 11 multidrug-resistant Klebsiella pneumoniae isolates, including ESBL genes (blaCTX-M-15, blaSHV-12, blaTEM-1B), fluoroquinolone resistance genes (oqxAB, qnrB), and others such as catA, catB, tet, sul, dfr, and fosA. These genes contribute to resistance against various antibiotics, highlighting the complex resistance profile of these isolates.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting.
The study identified various AMR genes and mutations in E. coli isolates from children with cystic fibrosis, cancer, and healthy controls, highlighting differences in resistance profiles between groups.
New eight genes identified at the clinical multidrug-resistant Acinetobacter baumannii DMS06669 strain in a Vietnam hospital.
The study identified 18 antibiotic resistance genes in the multidrug-resistant Acinetobacter baumannii DMS06669 strain, including eight novel genes not previously reported in A. baumannii. These genes conferred resistance to various antibiotic classes, including aminoglycosides, beta-lactams, phenicols, sulfonamides, tetracyclines, macrolides, lincosamides, streptogramin B, and rifampicins.
A Novel IncA/C1 Group Conjugative Plasmid, Encoding VIM-1 Metallo-Beta-Lactamase, Mediates the Acquisition of Carbapenem Resistance in ST104 Klebsiella pneumoniae Isolates from Neonates in the Intensive Care Unit of V. Monaldi Hospital in Naples.
The study identifies a novel IncA/C1 conjugative plasmid, pIncAC_KP4898, which carries the blaVIM-1 gene and other resistance genes, mediating carbapenem resistance in ST104 Klebsiella pneumoniae isolates from neonates in the NICU of V. Monaldi Hospital in Naples.
ARIBA: Rapid identification of antimicrobial resistance genes and variants from whole-genome sequencing data
The paper presents ARIBA, a tool for identifying antimicrobial resistance genes and mutations from sequencing data. It evaluates the performance of ARIBA on three datasets, demonstrating its accuracy and efficiency in detecting resistance genes and mutations in Enterococcus faecium, Shigella sonnei, and Neisseria gonorrhoeae.
CTX-M-15-Producing E. coli Isolates from Food Products in Germany Are Mainly Associated with an IncF-Type Plasmid and Belong to Two Predominant Clonal E. coli Lineages.
The study identifies bla CTX-M-15-positive E. coli isolates from food products in Germany, primarily associated with IncF-type plasmids and belonging to two predominant clonal lineages, ST167 and ST410. These isolates carry various resistance genes including aac(6')-Ib-cr, aadA5, bla OXA-1, catB3, mph(A), sul1, tet(B), and dfrA17.
Characterization of multiple antibiotic resistance of culturable microorganisms and metagenomic analysis of total microbial diversity of marine fish sold in retail shops in Mumbai, India.
The study identified multiple antibiotic resistance genes in marine fish isolates, including blaTEM, Class I integron, tetA, aph(3')-IIIa, ermB, aadA, and sul1, indicating a potential risk of antibiotic resistance transmission to humans through the food chain.
Porcine commensal Escherichia coli: a reservoir for class 1 integrons associated with IS26.
The study identified 17 antimicrobial resistance genes (ARGs) in 103 class 1 integron-positive Escherichia coli strains from porcine feces, highlighting the prevalence of multidrug-resistant commensal E. coli in pigs and their potential role in the dissemination of resistance genes.
High Prevalence of CTX-M-15-Type ESBL-Producing E. coli from Migratory Avian Species in Pakistan.
The study identified a high prevalence of CTX-M-15-type ESBL-producing E. coli in migratory avian species in Pakistan, highlighting the role of wild birds as reservoirs of multidrug-resistant bacteria and the potential for horizontal gene transfer of resistance determinants.
A historical legacy of antibiotic utilization on bacterial seed banks in sediments.
The study identifies and characterizes the tetracycline resistance gene tet(W) and the sulfonamide resistance gene sul1 in bacterial seed bank DNA from lake sediments, showing their historical accumulation patterns linked to antibiotic usage.
Peracetic acid disinfection kinetics for combined sewer overflows: indicator organisms, antibiotic resistance genes, and microbial community.
The study evaluated the efficacy of peracetic acid (PAA) in reducing antibiotic resistance genes (ARGs) and indicator organisms in simulated combined sewer overflow (CSO) effluent. It identified that PAA effectively reduced the concentrations of sul 1, tet (G), and BacHum in viable cells, with varying degrees of effectiveness depending on the PAA dosage and contact time.
Broad-spectrum resistance of Pseudomonas aeruginosa from shellfish: infrequent acquisition of novel resistance mechanisms.
The study identified the blaTEM-116 gene, sul1 gene, and aadA7 gene cassette in Pseudomonas aeruginosa isolates from shellfish, highlighting the presence of intrinsic and acquired resistance mechanisms in marine environments.
Comparison of antimicrobial resistance genes in feedlots and urban wastewater.
The study identified various antimicrobial resistance genes in feedlots and urban wastewater, highlighting the prevalence of sulfonamide, tetracycline, macrolide, fluoroquinolone, and β-lactam resistance genes in different environments.
Diversity and Antimicrobial Resistance Genotypes in Non-Typhoidal Salmonella Isolates from Poultry Farms in Uganda.
The study identified several antimicrobial resistance genes in non-typhoidal Salmonella isolates from Ugandan poultry farms, including blaTEM-1, cmlA, qnrS, tetA, sul1, dhfrI, and dhfrVII, which confer resistance to various antibiotics such as ampicillin, chloramphenicol, ciprofloxacin, tetracycline, sulfonamide, and trimethoprim.
Impact of Wastewater Treatment on the Prevalence of Integrons and the Genetic Diversity of Integron Gene Cassettes.
The study identified various antibiotic resistance genes within integron gene cassettes in wastewater treatment plants, including aadA1, aadA2, aadA5, blaOXA-1, blaOXA-10, blaOXA-101, blaOXA-129, blaOXA-21, blaOXA-28, catB8, dfrA14, erm, qacE2, sul1, tet, orfD, and orfA, which confer resistance to aminoglycosides, beta-lactams, chloramphenicol, trimethoprim, sulfonamides, tetracyclines, and quaternary ammonium compounds.
Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population.
The study identifies clinically relevant ESBL-producing K. pneumoniae ST307 and E. coli ST38 in an urban West African rat population, highlighting the presence of multidrug-resistant strains carrying various resistance genes such as blaCTX-M-15, blaCTX-M-14, blaCTX-M-9, and others.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Aeromonas caviae mimicking Vibrio cholerae infectious enteropathy in a cholera-endemic region with possible public health consequences: two case reports.
The study identified Aeromonas caviae causing cholera-like symptoms, which was initially mistaken for Vibrio cholerae. The isolates carried genes encoding resistance to beta-lactam, sulfonamide, and trimethoprim.
Genomic Analysis of a Pan-Resistant Isolate of Klebsiella pneumoniae, United States 2016.
The study reports a pan-resistant Klebsiella pneumoniae isolate with resistance to all 26 antibiotics tested, including multiple beta-lactamases, aminoglycoside modifying enzymes, sulfonamide resistance, and colistin resistance due to mgrB inactivation.
Characterization of antimicrobial resistance genes in Haemophilus parasuis isolated from pigs in China.
The study identified multiple antimicrobial resistance genes in Haemophilus parasuis isolates from pigs in China, including blaTEM-1, blaROB-1, ermB, ermA, flor, catl, tetB, tetC, rmtB, rmtD, aadA1, aac(3′)-IIc, sul1, and sul2. Additionally, mutations in the gyrA and parC genes were associated with fluoroquinolone resistance.
Serotype Diversity and Antimicrobial Resistance among Salmonella enterica Isolates from Patients at an Equine Referral Hospital.
The study identified various AMR genes in Salmonella enterica isolates from equine patients, including beta-lactamases, aminoglycoside modifying enzymes, and genes conferring resistance to tetracyclines, macrolides, and other antibiotics.
An outbreak of a rare Shiga-toxin-producing Escherichia coli serotype (O117:H7) among men who have sex with men.
The study identified several AMR genes and mutations in STEC O117:H7 isolates, including the azithromycin resistance gene mphA, aadA1, aadA2, aadA5, blaTEM-1B, blaTEM-1C, dfrA1, dfrA12, dfrA14, dfrA, dfrA5, ermB, strA, strB, sul1, sul2, tet(A), tet(B), qnrs1, and a mutation in gyrA (S83L) associated with fluoroquinolone resistance.
Polyphyletic Nature of Salmonella enterica Serotype Derby and Lineage-Specific Host-Association Revealed by Genome-Wide Analysis.
The study identified AMR genes aadA2, sul1, and tetA in Salmonella enterica serovar Derby strains, with a multidrug-resistant profile STR-SSS-TET in certain lineages.
The Use of a Combined Bioinformatics Approach to Locate Antibiotic Resistance Genes on Plasmids From Whole Genome Sequences of Salmonella enterica Serovars From Humans in Ghana.
The study identified several AMR genes in Salmonella isolates from Ghana, including blaTEM-1B, blaTEM-52B, blaCTX-M-15, tet(A), dfrA15, sul1, sul2, catA1, strA, strB, aadA1, catB3, qnrB1, aac(6')Ib-cr, and blaOXA-1. These genes were found on various plasmids, highlighting the diversity of resistance mechanisms in the studied isolates.
Case Report of an Extensively Drug-Resistant Klebsiella pneumoniae Infection With Genomic Characterization of the Strain and Review of Similar Cases in the United States.
The study identifies multiple AMR genes and mutations in an XDR-KP strain, including blaKPC-3, blaOXA-9, blaTEM-1A, and various resistance mechanisms involving efflux pumps, porin deficiencies, and fluoroquinolone resistance mutations.
Seasonal Variations in Water-Quality, Antibiotic Residues, Resistant Bacteria and Antibiotic Resistance Genes of Escherichia coli Isolates from Water and Sediments of the Kshipra River in Central India.
The study identified the presence of antibiotic resistance genes such as bla CTX-M-1, qnr S, sul1, and sul2 in Escherichia coli isolates from the Kshipra River, showing seasonal variations in their occurrence and resistance profiles.
Genetic analysis of invasive Escherichia coli in Scotland reveals determinants of healthcare-associated versus community-acquired infections.
The study identified several antibiotic resistance genes in E. coli isolates, including blaCTX-M-15, blaCTX-M-9, aac(3)-II, aac(6')-Ib, aadA1, dfrA1, sul1, sul2, mphA, and mrxA, which contribute to resistance against various antibiotics such as third-generation cephalosporins, aminoglycosides, trimethoprim, sulfonamides, and macrolides.
Dissemination of antibiotic resistance genes associated with the sporobiota in sediments impacted by wastewater.
The study identifies tet(W) and sul1 as prevalent antibiotic resistance genes in the sporobiota of sediments impacted by wastewater, showing their association with the wastewater treatment plant discharge and their spatial distribution patterns.
A pan-genome-based machine learning approach for predicting antimicrobial resistance activities of the Escherichia coli strains.
The study identifies and characterizes several AMR genes in E. coli, including beta-lactamases (blaTEM-1, blaOXA-1, blaCMY-2, ampC), aminoglycoside modifying enzymes (aac(3')-Ia, aac(3')-VI), dihydrofolate reductases (dfrA1, dfrA5, dfrA12, dfrA15), quinolone resistance proteins (qnrB2, qnrB6, qnrS2), and others. These genes were validated through computational and wet lab methods, showing their roles in conferring resistance to various antibiotics.
Spread and Persistence of Virulence and Antibiotic Resistance Genes: A Ride on the F Plasmid Conjugation Module.
The paper reviews the role of F-like plasmids in the spread and persistence of antibiotic resistance and virulence genes, highlighting the importance of these plasmids in the dissemination of resistance genes such as blaTEM-1, sul1, aadA, and catA1, as well as virulence factors like ompP and colicin genes.
Superficieibacter electus gen. nov., sp. nov., an Extended-Spectrum β-Lactamase Possessing Member of the Enterobacteriaceae Family, Isolated From Intensive Care Unit Surfaces.
The study identifies multiple antibiotic resistance genes in the newly described species Superficieibacter electus, including beta-lactamases, aminoglycoside modifying enzymes, and others, indicating its ability to resist various antibiotics.
A highly efficient sulfadiazine selection system for the generation of transgenic plants and algae.
The study shows that targeting the sul gene to mitochondria significantly improves sulfadiazine resistance and transformation efficiency in plants and algae, demonstrating the importance of proper subcellular localization for effective selectable marker function.
A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil.
The study reports a fatal case of bacteremia caused by a hypermucoviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae. The isolate harbored multiple AMR genes including blaKPC-2, blaSHV-11, qnrS1, oqxA, oqxB, sul1, sul2, dfrA1, tetA, tetD, and fosA, contributing to its extensive drug resistance.
Interplay Between the Phenotype and Genotype, and Efflux Pumps in Drug-Resistant Strains of Riemerella anatipestifer.
The study identified multiple AMR genes and mutations in Riemerella anatipestifer, including aac(6')-Ib, aadA1, aadA2, aadA5, aac(3')-IIc, aac(3')-IV, aph(3')-VII, aph(2')-Ib, bla TEM, bla OXA, tet(A), tet(B), sul1, sul2, sul3, cat2, cmlA, floR, emrF, qnrS, and qnrD. Additionally, mutations in gyrA and parC were found to confer fluoroquinolone resistance.
Comparative genomics of clinical strains of Pseudomonas aeruginosa strains isolated from different geographic sites.
The study identified several AMR genes in Pseudomonas aeruginosa strains from different geographic locations, including beta-lactamases, aminoglycoside resistance genes, fosfomycin resistance, chloramphenicol resistance, sulfonamide resistance, quaternary ammonium compound resistance, tetracycline resistance, and others. Indian eye isolates exhibited a higher diversity of resistance genes compared to Australian isolates.
Draft genome sequence data of a tigecycline-resistant Enterobacter cloacae ST93 clinical strain isolated from bloodstream infection.
The study reports the draft genome sequence of a tigecycline-resistant Enterobacter cloacae ST93 clinical isolate, TREC1, which harbors multiple antimicrobial resistance genes, including those encoding resistance to beta-lactams, aminoglycosides, fluoroquinolones, fosfomycin, macrolides, lincosamides, streptogramin B, phenicols, sulfonamides, trimethoprim, and tetracyclines. The isolate is resistant to all antibiotics tested except colistin.
Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.
The study identified various AMR genes and mutations in carbapenem-resistant Klebsiella pneumoniae isolates, including bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-48, ampC, qnrB, qnrS, aac(6')-Ib-cr, armA, rmtB, tet(A), tet(B), tet(D), tet(G), sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, dfrA25, dfrA26, dfrA30, oqxA, oqxB, and mgrB, as well as mutations in ompK35, ompK36, gyrA, parC, phoP, phoQ, pmrA, and pmrB, which contribute to resistance against multiple antibiotics.
The Transferable Resistome of Produce.
The study identified multiple tetracycline resistance genes, beta-lactamases, and other resistance determinants in E. coli isolates from produce, highlighting the potential for horizontal gene transfer and the significance of the produce microbiome as a reservoir of antibiotic resistance genes.
Interrelationship between tetracycline resistance determinants, phylogenetic group affiliation and carriage of class 1 integrons in commensal Escherichia coli isolates from cattle farms.
The study identified tetracycline resistance genes tet(A) and tet(B) as the most common in commensal E. coli isolates from cattle farms, along with gene cassettes such as aadA1, dfrA1, dfrA12, sul1, cat1, and floR associated with class 1 integrons.
Salmonella enterica Serovar Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial Resistance.
The study identified several AMR genes and mutations in S. Typhi isolates from Bangladesh, including blaTEM-1B, blaCTX-M-15, catA1, dfrA7, sul1, sul2, qnrS1, strA, strB, tet(A), tet(B), and mutations in gyrA and parE associated with ciprofloxacin resistance.
Reduction of Antibiotic Resistant Bacteria During Conventional and Advanced Wastewater Treatment, and the Disseminated Loads Released to the Environment.
The study identifies several antibiotic resistance genes (ARGs) in wastewater, including mecA, ctx-M32, ermB, blaTEM, sul1, vanA, and intI1, and evaluates the effectiveness of advanced wastewater treatment technologies in reducing their abundance.
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.
The study characterized the resistomes of six carbapenem-resistant pathogens, identifying various carbapenemase genes such as bla KPC-2, bla OXA-48, bla OXA-72, bla NDM-1, bla NDM-7, and bla VIM-1, along with other resistance genes like aac(6')-Ib-cr, aph(3")-Ib, aph(6)-Id, tet(B), erm(B), mph(A), sul1, sul2, dfrA17, dfrA14, bla CTX-M-15, bla CMY-6, bla OXA-1, bla SHV-200, bla OXA-10, and bla NDM-7.
Prediction of the intestinal resistome by a three-dimensional structure-based method.
The study predicts 6,095 antibiotic resistance determinants (ARDs) in the human intestinal microbiota using a three-dimensional structure-based method called pairwise comparative modelling (PCM). Experimental validation of 71 predicted ARDs showed that they conferred resistance to various antibiotics, including beta-lactams, aminoglycosides, tetracyclines, macrolides, quinolones, sulfonamides, trimethoprim, fosfomycin, and glycopeptides.
High abundances of class 1 integrase and sulfonamide resistance genes, and characterisation of class 1 integron gene cassettes in four urban wetlands in Nigeria.
The study identified high abundances of class 1 integrase (intI1) and sulfonamide resistance genes (sul1 and sul2) in urban wetlands in Nigeria, along with various gene cassettes in class 1 integrons that confer resistance to trimethoprim, aminoglycosides, rifampicin, and fluoroquinolones.
The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.
The study identifies multiple AMR genes associated with multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa, including genes encoding resistance to aminoglycosides, beta-lactams, chloramphenicol, trimethoprim, sulfonamides, and tetracyclines. It also notes mutations in the gyrA gene associated with reduced susceptibility to fluoroquinolones.
Study of class 1 integrons in multidrug-resistant uropathogenic Escherichia coli isolated from different hospitals in Karachi.
The study identified CTX-M1, TEM, and SHV as the predominant ESBL genes in MDR uropathogenic E. coli, along with class 1 integrons carrying intI1, qacEΔ1, and sul1.
Population Structure, Antibiotic Resistance, and Uropathogenicity of Klebsiella variicola.
The study identifies several antibiotic resistance genes in Klebsiella variicola, including blaLEN, oqxAB, blaKPC-2, blaNDM-1, blaNDM-9, blaOXA-48, aac(6')-Ib, aadA16, sul1, sul2, qnrB6, arr-3, and floR. These genes confer resistance to various antibiotics such as ampicillin, ciprofloxacin, meropenem, gentamicin, kanamycin, sulfamethoxazole, rifampin, and chloramphenicol.
Hospitalized Pets as a Source of Carbapenem-Resistance.
The study identified carbapenem-resistant bacteria in hospitalized pets, including Acinetobacter radioresistens carrying blaNDM-1 and Acinetobacter baumannii carrying blaOXA-23. Mutations in the oprD gene were associated with carbapenem resistance in Pseudomonas aeruginosa, and S. maltophilia exhibited resistance to trimethoprim/sulfamethoxazole due to sul1 and sul2 genes.
Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain.
The study shows that Acinetobacter baumannii A118 can acquire antibiotic resistance genes from other species through natural transformation, leading to increased resistance to various antibiotics such as meropenem, imipenem, and sulfamethoxazole.
The Prevalence of Colistin Resistant Strains and Antibiotic Resistance Gene Profiles in Funan River, China.
The study identified mcr-1 and mcr-3 genes as the primary colistin resistance genes in the Funan River, along with other resistance genes such as sul1, sul2, aac(6')-Ib-cr, bla CTX-M, tetM, ermB, qnrS, and aph(3')-IIIa. These genes were found in various bacterial species, highlighting the presence of multidrug-resistant strains in the river.
Diarrheal bacterial pathogens and multi-resistant enterobacteria in the Choqueyapu River in La Paz, Bolivia.
The study identified multidrug-resistant Enterobacteriaceae in the Choqueyapu River, including E. coli and Enterobacter cloacae carrying bla CTX-M, bla KPC, bla NDM, bla VIM, and bla OXA-48 genes, highlighting the environmental spread of antibiotic resistance.
Multidrug Resistant Uropathogenic Escherichia coli ST405 With a Novel, Composite IS26 Transposon in a Unique Chromosomal Location.
The study identifies a novel composite IS26 transposon, Tn6242, in multidrug-resistant E. coli ST405, carrying resistance genes including dfrA17, aadA5, sul1, mphA, strA, strB, blaTEM-1b, and sul2.
Virulence Characteristics and an Action Mode of Antibiotic Resistance in Multidrug-Resistant Pseudomonas aeruginosa.
The study identifies several AMR genes including aadB, aac(6')-31, aph(3')-VIa, blaOXA-1, sul1, and cmx in multidrug-resistant Pseudomonas aeruginosa strains, along with a gyrA mutation (T83I) conferring fluoroquinolone resistance.
Co-outbreak of multidrug resistance and a novel ST3006 Klebsiella pneumoniae in a neonatal intensive care unit: A retrospective study.
The study identified two clones of multidrug-resistant Klebsiella pneumoniae, ST37 and ST3006, in a neonatal intensive care unit. ST37 harbored multiple resistance genes, including OXA-33, TEM-1, SHV-11, and others, while ST3006 carried fewer resistance genes. Whole-genome sequencing revealed the presence of various antibiotic resistance genes and genomic islands.
Extensive drug resistant Salmonella enterica serovar Senftenberg carrying blaNDM encoding plasmid p5558 (IncA/C) from India.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Salmonella enterica serovar Senftenberg isolate, including blaNDM-1, blaTEM-1, blaOXA-9, blaCMY-2, aac(6')-Ia, aac(6')-Ib, aph(3')-Ib, aph(6')-Ib, ant(3'')-Ia, sul-1, sul-2, and florR. Additionally, mutations in gyrA (S83Y, D87G) and parC (S80I) were associated with fluoroquinolone resistance.
Comparative Genomic Analyses Reveal Core-Genome-Wide Genes Under Positive Selection and Major Regulatory Hubs in Outlier Strains of Pseudomonas aeruginosa.
The study identified genes under positive selection in Pseudomonas aeruginosa outlier strains, including oprD, which is implicated in carbapenem resistance through reduced uptake.
Cross-Border Transmission of Salmonella Choleraesuis var. Kunzendorf in European Pigs and Wild Boar: Infection, Genetics, and Evolution.
The study identified multiple antimicrobial resistance genes in Salmonella Choleraesuis isolates, including aadA1, catA1, cmlA1, floR, mph(B), strA, strB, sul1, sul2, sul3, tet(A), tet(B), dfrA1, aph(3')-Ia, lnu(B), and blaTEM-1. These genes conferred resistance to various antibiotics such as streptomycin, chloramphenicol, florfenicol, erythromycin, sulfamethoxazole, tetracycline, trimethoprim, gentamicin, lincomycin, and ampicillin.
Whole-genome analysis of extraintestinal Escherichia coli sequence type 73 from a single hospital over a 2 year period identified different circulating clonal groups.
The study identified multiple antibiotic resistance genes, including aadA1, sul1, and blaOXA-1, in ST73 isolates from a hospital in Sydney, highlighting the diversity of resistance mechanisms in these strains.
Characterization of the emerging multidrug-resistant Salmonella enterica serovar Indiana strains in China.
The study identifies multiple AMR genes, including aac(6')-Ib, blaOXA-30, catB3, arr-3, qacE, sul1, intI1, armA, msrE, mphE, and blaCTX-M-3, in multidrug-resistant Salmonella enterica serovar Indiana strains in China, highlighting the role of class I integrons in the dissemination of resistance.
Loss and Gain in the Evolution of the Salmonella enterica Serovar Gallinarum Biovar Pullorum Genome.
The study identifies multiple multidrug resistance plasmids in Salmonella Pullorum, including pSPUR1, pSPUR2, pSPUR3, pSPUR4, and pSPUR5, which confer resistance to various antibiotics such as trimethoprim, streptomycin, sulfonamide, and tetracycline.
Detection of fecal bacteria and antibiotic resistance genes in drinking water collected from three First Nations communities in Manitoba, Canada.
The study identified the presence of antibiotic resistance genes (ARGs) including ampC, mecA, and sul1 in drinking water samples from First Nations communities in Manitoba, Canada, highlighting potential risks to water safety.
Whole Genome Sequencing of Extended Spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae Isolated from Hospitalized Patients in KwaZulu-Natal, South Africa.
The study characterized multiple AMR genes in ESBL-producing K. pneumoniae isolates, including bla TEM-1B, bla CTX-M-15, bla SHV-1, bla OXA-1, aad AI6, aac (6′)Ib-cr, aph (6)Id, aph (3′)-Ib, oqx A, oqx B, fos A, ARR-3, sul 1, sul 2, dfr A14, dfr A27, cat A1, and cat B4.
Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging Klebsiella pneumoniae ST101 Lineage.
The study characterizes the antimicrobial resistance genes and mutations in the emerging Klebsiella pneumoniae ST101 lineage, highlighting the presence of multiple resistance mechanisms including carbapenemases, extended-spectrum beta-lactamases, and various other resistance genes.
Occurrence of Transferable Integrons and sul and dfr Genes Among Sulfonamide-and/or Trimethoprim-Resistant Bacteria Isolated From Chilean Salmonid Farms.
The study identified the presence of sul1, sul2, dfrA12, and dfrA14 genes in sulfonamide- and/or trimethoprim-resistant bacteria from Chilean salmonid farms, highlighting their potential for horizontal gene transfer through plasmids and integrons.
Phenotypic and genotypic characterization of enterotoxigenic Escherichia coli isolated from diarrheic calves in Argentina.
The study identified multidrug-resistant ETEC strains from diarrheic calves in Argentina, including the presence of integrons carrying resistance genes such as dhfrA1, aadA1, dhfrA17, aadA5, and sul1.
Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.
The study identifies multiple AMR genes and mutations in multidrug-resistant Salmonella enterica serotype Kentucky ST198, including genes such as blaTEM-1, aacA4, aadA1, sul1, tetA, catA1, mph(A), blaCTX-M-1, blaOXA-48, blaNDM-1, blaCMY-2, and dfrA12, along with mutations in gyrA and parC that confer resistance to various antibiotics.
Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors.
The study identified several antimicrobial resistance genes in Escherichia coli isolates from broiler chickens in Jordan, including tetA, tetB, int1, sul1, sul2, blaTEM, and cat. These genes were associated with resistance to various antibiotics such as tetracycline, sulfonamides, beta-lactams, and chloramphenicol.
Diverse Commensal Escherichia coli Clones and Plasmids Disseminate Antimicrobial Resistance Genes in Domestic Animals and Children in a Semirural Community in Ecuador.
The study identified various antimicrobial resistance (AMR) genes in commensal Escherichia coli isolates from children and domestic animals in a semirural community in Ecuador. These genes included blaTEM-1B, dfrA8, qnrB19, strA, strB, tetA, tetB, sul1, sul2, and others, contributing to resistance against multiple antibiotics such as ampicillin, trimethoprim, tetracycline, and sulfamethoxazole. The research highlights the role of plasmids in disseminating these AMR genes and emphasizes the complexity of AMR transmission in such environments.
Multiomics Assessment of Gene Expression in a Clinical Strain of CTX-M-15-Producing ST131 Escherichia coli.
The study identifies multiple AMR genes and mutations in the CTX-M-15-producing ST131 E. coli strain C999, including beta-lactamases (blaCTX-M-15, blaTEM-1, blaOXA-1), aminoglycoside resistance gene (aac(6')-Ib-cr), tetracycline resistance gene (tet(A)), sulfonamide resistance gene (sul1), and aadA5 gene cassette. Mutations in gyrA and parC contribute to fluoroquinolone resistance.
Ceftriaxone-resistant Salmonella enterica serotype Typhi in a pregnant traveller returning from Karachi, Pakistan to Denmark, 2019.
The study reports a ceftriaxone-resistant Salmonella Typhi isolate carrying multiple resistance genes, including blaCTX-M-15, blaTEM-1B, qnrS1, sul1, sul2, dfrA7, aph[3]-1b, aph[6]-1d, aac[6]-1aa, and catA1. Additionally, a fluoroquinolone resistance mutation (gyrA S83F) was identified.
Antibiotic Resistance of E. coli Isolated From a Constructed Wetland Dominated by a Crow Roost, With Emphasis on ESBL and AmpC Containing E. coli.
The study identified bla ctx-M and bla cmy-2 genes as major contributors to extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase resistance in E. coli isolates from a constructed wetland dominated by a crow roost. Tetracycline resistance was primarily mediated by tet (A), tet (B), and tet (M), while streptomycin resistance was linked to strA, strB, and aadA. Sulfamethoxazole/trimethoprim resistance was associated with the sul1 gene.
Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection.
The study presents a nanopore metagenomics method for rapid detection of bacterial pathogens and antibiotic resistance genes in lower respiratory infections, achieving high sensitivity and specificity through host DNA depletion and real-time sequencing.
Evaluation of The Pathogenic Potential of Insecticidal Serratia marcescens Strains to Humans.
All S. marcescens strains were resistant to sulfamethoxazole due to the presence of sul1 or sul2 genes. The study highlights the potential pathogenicity of S. marcescens to humans and the risks associated with using antibiotic-resistant strains as bioinsecticides.
Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.
The study identified various AMR genes and mutations in Salmonella enterica serovar Typhimurium, including aadA, strAB, blaTEM, blaCARB, floR, cmlA1, catA1, qnrB19, sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, tetA, tetB, tetC, tetG, and mutations in gyrA. These genes and mutations were validated through whole genome sequencing and phenotypic ASTs.
Dissemination of Multidrug-Resistant Commensal Escherichia coli in Feedlot Lambs in Southeastern Brazil.
The study identified multiple multidrug-resistant commensal E. coli isolates in feedlot lambs in Brazil, carrying various AMR genes including bla CTX-M-2, bla CTX-M-8, bla CTX-M-14, bla CTX-M-15, bla CMY-2, aac(3)-IIa, ant(2")-Ia, qnrB, tetA, tetB, sul1, sul2, floR, and cmlA. These genes confer resistance to beta-lactams, aminoglycosides, quinolones, tetracyclines, sulfonamides, and phenicols.
Genomic Features of High-Priority Salmonella enterica Serovars Circulating in the Food Production Chain, Brazil, 2000-2016.
The study identified several AMR genes in Salmonella enterica isolates from Brazil, including qnrE1, qnrB19, qnrS1, blaCTX-M-2, blaCTX-M-8, blaCMY-2, aadA1, aadA2, aac(3)-IVa, aac(3)-IIa, aac(6')-Ib, floR, sul1, sul2, tet(A), tet(B), strA, strB, drfA1, inu(F), qacEdelta1, and fosA7. These genes conferred resistance to various antibiotics such as fluoroquinolones, beta-lactams, aminoglycosides, sulfonamides, tetracyclines, chloramphenicol, trimethoprim, macrolides, quaternary ammonium compounds, and fosfomycin.
Molecular Epidemiology of Multidrug-Resistant Klebsiella pneumoniae Isolates in a Brazilian Tertiary Hospital.
The study identified various AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates, including bla KPC, bla CTX-M, bla TEM, and mutations in ompk35, ompk36, gyrA, and parC. These findings highlight the complex resistance mechanisms contributing to the persistence of MDR-Kp in the hospital setting.
Population dynamics of an Escherichia coli ST131 lineage during recurrent urinary tract infection.
The study identified multiple AMR genes and mutations in E. coli ST131 isolates from a patient with recurrent UTIs, including plasmid-borne resistance genes and chromosomal mutations contributing to fluoroquinolone resistance.
Bogotá River anthropogenic contamination alters microbial communities and promotes spread of antibiotic resistance genes.
The study identifies multiple antibiotic resistance genes (ARGs) in water samples from the Bogotá River and hospital wastewaters, indicating the spread of resistance due to anthropogenic contamination.
Multilocus sequence typing and bla (ESBL) characterization of extended-spectrum beta-lactamase-producing Escherichia coli isolated from healthy humans and swine in Northern Thailand.
The study identified bla CTX-M, bla TEM, and bla SHV as the primary ESBL genes in ESBL-producing E. coli isolates from healthy humans and swine in Northern Thailand. Additionally, several other AMR genes such as sul1, sul2, sul3, aadA22, aph(3')-Ia, strA, strB, aadA2, aadA5, qnrS1, tetA, tetB, tetD, arr2, and mefB were characterized.
Tracking Carbapenem-Producing Klebsiella pneumoniae Outbreak in an Intensive Care Unit by Whole Genome Sequencing.
The study identified multiple carbapenem-resistant Klebsiella pneumoniae (CP-Kp) strains carrying various resistance genes, including blaKPC-2, blaNDM-1, and others, contributing to multidrug resistance. Plasmid analysis revealed the presence of resistance genes on different plasmids, highlighting the complexity of resistance mechanisms.
High Prevalence of Metallo-β-Lactamase-Producing Enterobacter cloacae From Three Tertiary Hospitals in China.
The study identified multiple metallo-beta-lactamase genes, including blaNDM-1, blaIMP-26, blaIMP-4, blaIMP-1, blaVIM-4, and blaKPC-2, as major contributors to carbapenem resistance in Enterobacter cloacae isolates from three hospitals in China.
Clinical Resistome Screening of 1,110 Escherichia coli Isolates Efficiently Recovers Diagnostically Relevant Antibiotic Resistance Biomarkers and Potential Novel Resistance Mechanisms.
The study identifies several AMR genes including aac(3)-IIa, aac(6')-lb-cr, ant (2")-Ia, aph3'-1, dfrA14, dfrA17, sul1, and qnrB19, which confer resistance to Tobramycin, Ciprofloxacin, and Trimethoprim-Sulfamethoxazole. These genes were validated through cloning and MIC testing.
Characterization of Discriminatory Antimicrobial Resistance Genes in Aquatic Environments Using Machine Learning
The study identifies discriminatory antibiotic resistance genes (ARGs) using an extremely randomized tree (ERT) algorithm, highlighting genes like sul1, tet(W), and ermB as significant markers for differentiating resistomes across various aquatic environments.
Evolution of Outbreak-Causing Carbapenem-Resistant Klebsiella pneumoniae ST258 at a Tertiary Care Hospital over 8 Years.
The study identifies various AMR genes in ST258 K. pneumoniae isolates, including blaKPC-2, blaKPC-3, aadA2, aadA1, blaTEM-1A, blaSHV-11, blaSHV-12, oqxA, oqxB, fosA, dfrA12, dfrA14, sul1, sul2, catA1, cml, and strAB, which confer resistance to multiple antibiotics.
Dissemination prevention of antibiotic resistant and facultative pathogenic bacteria by ultrafiltration and ozone treatment at an urban wastewater treatment plant.
The study analyzed the effectiveness of ultrafiltration and ozone treatment in reducing antibiotic resistance genes (ARGs) and facultative pathogenic bacteria in wastewater. It identified several ARGs, including sul1, blaTEM, tetM, CTX-M, CTX-M-32, blaOXA-48, blaVIM, CMY-2, vanA, mcr-1, blaNDM, ermB, and intl1, which were found to be prevalent in the wastewater. Both ultrafiltration units showed significant reduction in these ARGs and pathogenic bacteria, whereas ozone treatment was less effective.
Phenotypic and genotypic characterization of antibiotic-resistant in Escherichia coli isolates from patients with diarrhea.
The study identified several antibiotic resistance genes in E. coli isolates from patients with diarrhea, including dfrA1, sul1, citm, tetA, and qnr, which contribute to resistance against trimethoprim, sulfamethoxazole, ampicillin, tetracycline, and ciprofloxacin, respectively.
Characterization of a Carbapenem-Resistant Kluyvera Cryocrescens Isolate Carrying Bla(ndm-1) from Hospital Sewage.
The study characterizes a carbapenem-resistant Kluyvera cryocrescens isolate carrying blaNDM-1 on a self-transmissible IncX3 plasmid, along with other resistance genes such as blaSHV-12, blaCTX-M-3, qnrS1, sul1, fosA, dfrA21, and dfrA14.
Infectious phage particles packaging antibiotic resistance genes found in meat products and chicken feces.
The study identified various antibiotic resistance genes (ARGs) in phage particles from meat products and chicken feces, highlighting the potential role of phages in the dissemination of resistance.
Genetic characterization of a novel sequence type of multidrug-resistant Citrobacter freundii strain recovered from wastewater treatment plant.
The study reports the identification of a multidrug-resistant Citrobacter freundii strain R17 carrying 13 antibiotic-resistance genes, including blaCMY-85, aadA2, aac(3)-lld, blaDHA-1, blaTEM-1B, qnrB4, mph(A), catA2, sul1, sul2, tet(D), and dfrA12, which confer resistance to various antibiotic classes.
Inter-host Transmission of Carbapenemase-Producing Escherichia coli among Humans and Backyard Animals.
The study identified blaNDM genes as the primary cause of carbapenem resistance in Escherichia coli isolates from humans, pigs, chickens, and flies in rural China, highlighting the transmission of these resistance genes between humans and backyard animals.
Florfenicol Resistance in Enterobacteriaceae and Whole-Genome Sequence Analysis of Florfenicol-Resistant Leclercia adecarboxylata Strain R25.
The study identifies the floR gene as a major contributor to florfenicol resistance in Enterobacteriaceae, particularly in Leclercia adecarboxylata strain R25. Other resistance genes such as mdfA, aac(6')-Ib-cr, aadA16, qnrB6, sul1, dfrA27, arr-3, and qacEΔ1 were also characterized.
The Resistome, Mobilome, Virulome and Phylogenomics of Multidrug-Resistant Escherichia coli Clinical Isolates from Pretoria, South Africa.
The study characterized the resistome, mobilome, and virulome of 20 multidrug-resistant E. coli isolates from Pretoria, South Africa. Key findings include the identification of various beta-lactamase genes (blaCTX-M-15, blaCTX-M-14, blaCTX-M-27, blaOXA-1, blaOXA-10, blaTEM-1B), aminoglycoside resistance genes (aac(3)-IIa, aac(3)-IId, aac(6')-Ib-cr, mph(A)), sulfonamide resistance genes (sul1, sul2, sul3), dihydrofolate reductase genes (dfrA17, dfrA14, dfrA1, dfrA5, dfrA7, dfrA12, dfrA23), tetracycline resistance genes (tet(A), tet(B)), chloramphenicol resistance genes (catB3, catA1), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE.
WGS based study of the population structure of Salmonella enterica serovar Infantis.
The study identified multiple resistance genes, including aadA1, sul1, tetA, and dfrA14, carried on a pESI-like plasmid in multidrug-resistant Salmonella enterica serovar Infantis strains.
Complex Class 1 Integron in a Clinical Escherichia coli Strain From Vietnam Carrying Both mcr-1 and bla (NDM-1).
The study identifies a multidrug-resistant E. coli strain carrying both mcr-1 and bla NDM-1, highlighting the co-existence of colistin and carbapenem resistance genes in Vietnam.
First Report of Coexistence of Three Different MDR Plasmids, and That of Occurrence of IMP-Encoding Plasmid in Leclercia adecarboxylata.
The study reports the first identification of three different multidrug-resistant (MDR) plasmids in a single clinical isolate of Leclercia adecarboxylata, including the blaIMP-8 gene encoded on an IMP-encoding plasmid. These plasmids harbor various AMR genes such as blaIMP-8, aacC2, aadA2, mph(A), sul1, qacED1, mer, chrA, dfrA12, tmrB, catA1, catB8, tet(C), blaCTX-M-9, and blaTEM-1.
Evolution of Antibiotic Resistance and the Relationship between the Antibiotic Resistance Genes and Microbial Compositions under Long-Term Exposure to Tetracycline and Sulfamethoxazole.
The study identified the expansion of tetracycline and sulfonamide resistance genes, particularly tetC and sul1, under long-term exposure to tetracycline and sulfamethoxazole in wastewater treatment systems.
Phylogenetic Diversity, Antimicrobial Susceptibility and Virulence Characteristics of Escherichia coli Isolates from Pigeon Meat.
The study identified several AMR genes in E. coli isolates from pigeon meat, including ampC, aadA, cmlA, sul1, sul2, and sul3, which confer resistance to beta-lactams, aminoglycosides, chloramphenicol, and sulfonamides.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Effects of a Four-Week High-Dosage Zinc Oxide Supplemented Diet on Commensal Escherichia coli of Weaned Pigs.
The study identifies several antibiotic resistance genes (ARGs) and zinc tolerance genes in commensal Escherichia coli from weaned pigs, highlighting the impact of high-dose zinc oxide diets on selecting for resistant strains.
Multidrug-Resistant and Clinically Relevant Gram-Negative Bacteria Are Present in German Surface Waters.
The study identifies several AMR genes in multidrug-resistant Gram-negative bacteria isolated from German surface waters, highlighting the presence of clinically relevant resistance mechanisms such as bla CTX-M-1, bla CTX-M-15, mcr-1, and others.
Engineering a CRISPR Interference System To Repress a Class 1 Integron in Escherichia coli.
The study demonstrates that a CRISPRi system can effectively repress the class 1 integron in E. coli, significantly reducing antibiotic resistance and horizontal gene transfer of ARGs.
Emergence of carbapenemase-producing Enterobacteriaceae in Malawi.
The study reports the detection of an NDM-5 producing E. coli in Malawi, highlighting the emergence of carbapenem-resistant Enterobacteriaceae in the region.
Molecular epidemiology and antimicrobial resistance features of Acinetobacter baumannii clinical isolates from Pakistan.
The study identified multiple antimicrobial resistance genes in Acinetobacter baumannii isolates from Pakistan, including bla OXA-23, bla GES-11, aphA6a, aacA4, sul1, drfA7, msr(E), and mph(E). These genes contribute to resistance against various antibiotics such as carbapenems, cephalosporins, aminoglycosides, sulfonamides, and macrolides.
New Delhi Metallo-β-Lactamase-5-Producing Escherichia coli in Companion Animals, United States.
The study identifies a carbapenem-resistant Escherichia coli isolate producing New Delhi metallo-beta-lactamase-5 (blaNDM-5) in companion animals in the United States, along with several other resistance genes including tet(A), aac(6')-Ib-cr, aadA5, aadA2, blaOXA-1, blaCTX-M-15, catB3, dfrA17, dfrA12, sul1, and mph(A).
Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing.
The study identified multiple AMR genes in extensively drug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (blaSHV-11, blaTEM-1B, blaVEB-1, blaOXA-10, blaKPC-2, blaOXA-9, blaVIM-27, blaCTX-M-15, blaOXA-1, blaOXA-48), aminoglycoside resistance genes (aadA1, ant(2'')-Ia, aph(6)-Id, arr-2, aadA24, aph(3')-Ia, aph(6)-Id, aac(3)-IIa, aac(6')Ib-cr, aac(6')-Ib, aac(6')-Ib-cr), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet(A), tet(G)), trimethoprim resistance genes (dfrA1, dfrA14, dfrA23), chloramphenicol resistance genes (cmlA1, catB4), and others.
Prevalence and characteristics of multidrug-resistant mcr-1-positive Escherichia coli isolates from broiler chickens in Tai'an, China.
The study identified mcr-1 as the primary cause of colistin resistance in E. coli isolates from broiler chickens in Tai'an, China, with high prevalence of multidrug resistance involving genes like bla TEM, bla CTX-M, aphA3, tetA, tetB, tetC, sul1, and sul2.
Complete Nucleotide Sequence of Plasmids of Two Escherichia coli Strains Carrying bla (NDM-) (5) and bla (NDM) (-) (5) and bla (OXA) (-) (181) From the Same Patient.
The study characterizes two carbapenemase-producing E. coli strains carrying blaNDM-5 and blaOXA-181, along with various other resistance genes such as qnrS1, blaCTX-M-15, aac(6')-lb-cr, catB3, sul1, dfrA17, qacEΔ1, aadA5, rmtB, ermB, mphA, tetB, catA1, dfrA14, dfrA12, blaTEM-1B, and blaCMY-42.
Genomic Investigation Reveals Contaminated Detergent as the Source of an Extended-Spectrum-β-Lactamase-Producing Klebsiella michiganensis Outbreak in a Neonatal Unit.
Population structure and antimicrobial resistance patterns of Salmonella Typhi isolates in urban Dhaka, Bangladesh from 2004 to 2016.
Carbapenem-Resistant Enterobacter hormaechei ST1103 with IMP-26 Carbapenemase and ESBL Gene bla (SHV-178).
The study identifies a multidrug-resistant Enterobacter hormaechei strain L51 carrying the bla IMP-26 carbapenemase gene and bla SHV-178 ESBL gene, along with other resistance genes on a conjugative IncHI2/2A plasmid.
Comparative genomic analysis reveals high intra-serovar plasticity within Salmonella Napoli isolated in 2005-2017.
The study identifies acquired antimicrobial resistance genes in Salmonella Napoli, including aadA, bla, tet, and sul, which confer resistance to streptomycin, beta-lactams, tetracyclines, and sulfonamides, respectively.
Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: prevalence, risk factors, and molecular epidemiology.
The study identified several AMR genes in Gram-negative bacteria isolated from LTCF residents, including bla CTX-M-27, bla CTX-M-14, bla TEM-1B, bla IMP-1, and others, which confer resistance to various antibiotics such as β-lactams, aminoglycosides, and fluoroquinolones.
Two New SGI1-LK Variants Found in Proteus mirabilis and Evolution of the SGI1-HKL Group of Salmonella Genomic Islands.
The study identifies two new SGI1-LK variants, SGI1-LK1 and SGI1-LK2, in Proteus mirabilis isolates, highlighting the evolutionary dynamics of the SGI1-HKL group of Salmonella genomic islands.
Genotypic characterization of multiple drug resistant Escherichia coli isolates from a pediatric cancer hospital in Egypt.
The study identified multiple drug-resistant Escherichia coli isolates from a pediatric cancer hospital in Egypt, highlighting the prevalence of various antimicrobial resistance genes such as TEM-220, NDM-11, aph(6)-Id, sul2, and others, indicating a significant threat to immunocompromised patients.
Genome-Based Analysis of Extended-Spectrum β-Lactamase-Producing Escherichia coli in the Aquatic Environment and Nile Perch (Lates niloticus) of Lake Victoria, Tanzania.
The study identified multiple AMR genes in ESBL-producing E. coli from Nile perch and water samples in Lake Victoria, including bla CTX-M-15, bla TEM-1B, aadA2, aac(3)-IId, sul1, sul2, dfrA12, qepA4, tetB, tetD, mphA, mdfA, catA1, strA, strB, nfaE, iss, vat, and lpfA.
Phylogenetic Grouping of Human Ocular Escherichia coli Based on Whole-Genome Sequence Analysis.
The study identified 22 AMR genes in 10 ocular E. coli isolates, including bla CTX-M-15, dfrA17, aadA2, aadA5, bla OXA-1, bla NDM-5, dfrA12, bla TEM-1 B, mdfA, emrB, mphA, sul1, sul2, and aac(6')-1b-cr. Additionally, chromosomal mutations in parE, gyrA, and parC were found to confer resistance to fluoroquinolones.
Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report.
Putative Protein Biomarkers of Escherichia coli Antibiotic Multiresistance Identified by MALDI Mass Spectrometry.
The study identifies several AMR genes in E. coli isolates, including tet(A), tet(B), blaCTX-M, blaTEM, blaSHV, sul1, sul2, sul3, cmlA, aac(3)-II, aac(3)-IV, aadA, and strA-strB, which confer resistance to tetracycline, ampicillin, cefoxitin, trimethoprim-sulfamethoxazole, chloramphenicol, gentamicin, and streptomycin.
Metadata Analysis of mcr-1-Bearing Plasmids Inspired by the Sequencing Evidence for Horizontal Transfer of Antibiotic Resistance Genes Between Polluted River and Wild Birds.
The study identifies the mcr-1 gene as a key factor in colistin resistance in E. coli strains isolated from polluted rivers and wild birds. It also characterizes several other AMR genes including aadA1, aadA2, aph(3′)-Ia, aph(3″)-Ib, aph(4)-Ia, aph(6)-Id, tet(B), tet(D), tet(A), bla CTX–M–14, bla TEM–1, qnrS2, oqxA, oqxB, cmlA1, floR, vgaC, sul1, sul2, sul3, dfrA12, and glpT (E448K).
Antibiotic-resistant Escherichia coli isolated from urban rodents in Hanoi, Vietnam.
The study identified multiple antimicrobial resistance genes in Escherichia coli isolated from urban rodents in Hanoi, Vietnam, including bla TEM, tet(A), sul1, sul2, sul3, and mcr-1, highlighting the potential of rodents as reservoirs of multidrug-resistant and colistin-resistant E. coli.
International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil.
The study identified various AMR genes in CTX-M-producing E. coli isolates from peri-urban wild animals in Brazil, including bla CTX-M-55, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, and others, indicating the presence of multidrug-resistant bacteria in wildlife.
Genomic Analysis of GC1 Strains from H1 Hospital
The study identifies various AMR genes in GC1 Group 1 and Outgroup Group 3 genomes, including aac(6')-Ib, aph(3')-Ia, aac(3)-IIa, sul1, sul2, tet(A), tet(G), catA1, intI1, intI2, and efflux pumps adeABC, adeIJK, and adeFGH. These genes contribute to multidrug resistance in Acinetobacter baumannii.
Systematic Evaluation of Whole Genome Sequence-Based Predictions of Salmonella Serotype and Antimicrobial Resistance.
The study evaluated the performance of various bioinformatics tools for predicting antimicrobial resistance (AMR) and serotypes of Salmonella enterica using whole-genome sequencing (WGS). It identified several AMR genes and mutations associated with resistance to various antibiotics.
Novel Mobilizable Genomic Island GEI-D18A Mediates Conjugational Transfer of Antibiotic Resistance Genes in the Multidrug-Resistant Strain Rheinheimera sp. D18.
The study characterizes a novel mobilizable genomic island, GEI-D18A, in the multidrug-resistant strain Rheinheimera sp. D18, which carries several antibiotic resistance genes including aadA1, aacA3, tet(B), catA, dfrA37, and three sul1 genes. The transferability of GEI-D18A was confirmed through mating experiments, demonstrating its role in the conjugational transfer of antibiotic resistance genes.
Emergence of a Multidrug-Resistant Enterobacter hormaechei Clinical Isolate from Egypt Co-Harboring mcr-9 and bla(VIM-4).
The study reports the first complete genomic sequence of an mcr-9 and bla VIM-4 -carrying multidrug-resistant Enterobacter hormaechei clinical isolate from Egypt, highlighting the coexistence of these resistance genes on an IncHI2 plasmid and their potential for dissemination.
Antimicrobial resistance of Escherichia coli isolated from retail foods in northern Xinjiang, China.
The study identified various antimicrobial resistance genes in Escherichia coli isolates from retail foods in northern Xinjiang, China, including tetA, tetB, blaOXA, blaTEM, floR, sul1, sul2, aadAla, aadB, strA, and strB. These genes conferred resistance to tetracycline, beta-lactams, chloramphenicol, sulfonamides, and streptomycin.
Antimicrobial resistance of Escherichia coli isolated from retail foods in northern Xinjiang, China.
The study identified various antimicrobial resistance genes in Escherichia coli isolates from retail foods in northern Xinjiang, China, including tetA, tetB, blaOXA, blaTEM, floR, sul1, sul2, aadAla, aadB, strA, and strB. These genes conferred resistance to tetracycline, beta-lactams, chloramphenicol, sulfonamides, and streptomycin.
Novel Insights and Features of the NDM-5-Producing Escherichia coli Sequence Type 167 High-Risk Clone.
The study identifies the NDM-5-producing Escherichia coli sequence type 167 clone, highlighting its resistance mechanisms and the presence of various resistance genes such as blaNDM-5, aadA2, dfrA12, sul1, tet(A), mphA, rmtB, and aac(3)-IIa.
An NDM-1-Producing Acinetobacter towneri Isolate from Hospital Sewage in China.
Functional and structural map of pLST1000: A multiresistance plasmid widely distributed in Enterobacteriaceae.
The study characterizes the multiresistance plasmid pLST1000, identifying several AMR genes including aadB, aadA, bla-TEM, bla-OXA2, sul, and mer, which confer resistance to gentamicin, streptomycin, ampicillin, sulfonamide, and mercury, respectively.
Co-occurrence of mcr-1, mcr-3, mcr-7 and clinically relevant antimicrobial resistance genes in environmental and fecal samples.
The study identified the co-occurrence of mcr-1, mcr-3, mcr-7.1, and various clinically relevant antimicrobial resistance genes in environmental and fecal samples from a Brazilian zoo, highlighting the potential reservoir of these genes in zoological environments.
Antimicrobial Resistance Profiles of Adherent Invasive Escherichia coli Show Increased Resistance to β-Lactams.
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
The study identified several AMR genes and mutations in Salmonella Typhi isolates, including beta-lactamases (blaTEM-1B, blaTEM-116), chloramphenicol resistance gene (catA1), trimethoprim resistance genes (dfrA7, dfrA15), sulfamethoxazole resistance genes (sul1, sul2), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE genes.
Metagenomic Diagnosis for a Culture-Negative Sample From a Patient With Severe Pneumonia by Nanopore and Next-Generation Sequencing.
The study identified several AMR genes in a culture-negative sample from a patient with severe pneumonia, including bla SHV-12, bla KPC-2, bla TEM-1, bla CTX-M-65, aac(3)-IIa, aadA1, dfrA1, sul1, aph(3')-Ia, catA1, fosA, acrA, and rmtB, which confer resistance to various antibiotics.
Sulfamethoxazole affects the microbial composition and antibiotic resistance gene abundance in soil and accumulates in lettuce.
The study found that sulfamethoxazole (SMX) contamination significantly increased the relative abundance of the sulfonamide resistance gene sul1 in soil, while other antibiotic resistance genes remained unchanged.
Nanopore sequencing reveals genomic map of CTX-M-type extended-spectrum β-lactamases carried by Escherichia coli strains isolated from blue mussels (Mytilus edulis) in Norway.
The study identified CTX-M-type extended-spectrum beta-lactamases in Escherichia coli strains isolated from blue mussels in Norway, highlighting the potential for mobility of these resistance genes.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines.
The study identifies various carbapenemase genes such as blaNDM-1, blaNDM-7, blaCTX-M-15, and blaOXA-181, along with other AMR genes like rmtC, sul1, aac(6')-Ib-cr, mph(A), qnrB1, and others, which contribute to resistance against multiple antibiotics in Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa in the Philippines.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Host dependent maintenance of a bla(NDM-1)-encoding plasmid in clinical Escherichia coli isolates.
The study characterizes a blaNDM-1-encoding plasmid in clinical E. coli isolates, highlighting its ability to transfer between different genetic backgrounds and its association with carbapenem resistance.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Genes Encoding the Virulence and the Antimicrobial Resistance in Enterotoxigenic and Shiga-Toxigenic E. coli Isolated from Diarrheic Calves.
The study identified aadB, sul1, and bla-TEM as the primary antimicrobial resistance genes in E. coli isolates from diarrheic calves, with aadB being the most prevalent.
Co-Occurrence of the bla (KPC-2) and Mcr-3.3 Gene in Aeromonas caviae SCAc2001 Isolated from Patients with Diarrheal Disease.
The study identifies multiple antimicrobial resistance genes in Aeromonas caviae SCAc2001, including blaKPC, mcr-3.3, and others, highlighting the potential public health risks posed by this strain.
Molecular identification and antibiotic resistance profiling of Salmonella species isolated from chickens in eastern Turkey.
The study identified the presence of antibiotic resistance genes sul1, tetA, and blaTEM in Salmonella isolates from chickens in eastern Turkey, with sul1 being the most frequently detected gene.
Detection of Extended-Spectrum β-Lactamases (ESBL) Producing Enterobacteriaceae from Fish Trapped in the Lagoon Area of Bizerte, Tunisia.
The study identified several β-lactamase genes (bla CTX-M-1, bla CTX-M-15, bla CTX-M-9, bla OXA-1, and bla TEM-1-a) and other resistance genes (sul1, sul2, tetA, aac(6')-Ib-cr, qnrA, and qnrB) in ESBL-producing Enterobacteriaceae isolated from fish in the Bizerte lagoon, highlighting the presence of multidrug-resistant bacteria in aquatic environments.
Genomic analyses of multidrug-resistant Salmonella Indiana, Typhimurium, and Enteritidis isolates using MinION and MiSeq sequencing technologies.
The study identified various AMR genes in multidrug-resistant Salmonella isolates, including beta-lactamases (blaCTX-M-14, blaCTX-M-27, blaCTX-M-55, blaOXA-1, blaCMY-2, blaOXA, blaCMY), phenicol resistance genes (catB3, cmlA1, floR, catA1, catA2, oqxA, oqxB), aminoglycoside resistance genes (aac(6')-Ib-cr5, aac(6')-Ib-cr, oqxA2, qepA1, qnrS1), sulfonamide and trimethoprim resistance genes (sul1, sul2, sul3, dfrA12, dfrA7), and tetracycline resistance genes (tet(A), tet(B), tet(M)).
Molecular characteristics of fluoroquinolone-resistant avian pathogenic Escherichia coli isolated from broiler chickens.
The study identified several AMR genes and mutations in fluoroquinolone-resistant avian pathogenic Escherichia coli (APEC) isolates, including qnrA, qnrS, blaCTX-1, blaCTX-15, blaTEM-1, aac(3)-II, tetA, sul1, sul2, and catA1, along with mutations in gyrA and parC that confer fluoroquinolone resistance.
Whole Genome Sequencing and Characterization of Multidrug-Resistant (MDR) Bacterial Strains Isolated From a Norwegian University Campus Pond.
The study identifies multiple AMR genes and mutations in ESBL-producing bacteria from Norwegian freshwater environments, highlighting the presence of multidrug-resistant strains with resistance to various antibiotics including beta-lactams, fluoroquinolones, and sulfonamides.
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The study identified multiple AMR genes, including bla CTX-M-55, bla CMY-2, bla CTX-M-1, bla SHV-12, sul2, aac(3)-Ia, aadA, strA, strB, tet(A), tet(B), dfrA14, floR, cmlA1, catA1, catB3, qnrS1, qnrS2, qnrB19, mph(A), mph(B), arr-3, and aac(6')Ib-cr, in ESBL/pAmpC-producing E. coli isolates from broiler production.
Antibiotic Resistance Patterns of Pseudomonas spp. Isolated From Raw Milk Revealed by Whole Genome Sequencing.
The study identified various AMR genes and mutations in Pseudomonas spp. isolated from raw milk, highlighting the prevalence of multidrug-resistant strains and the presence of resistance determinants such as beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps.
Tracking Recombination Events That Occur in Conjugative Virulence Plasmid p15WZ-82_Vir during the Transmission Process.
The study characterizes the recombination events in the conjugative virulence plasmid p15WZ-82_Vir during transmission, identifying multiple antibiotic resistance genes and their roles in the formation of mosaic plasmids that carry both virulence and resistance traits.
AbGRI4, a novel antibiotic resistance island in multiply antibiotic-resistant Acinetobacter baumannii clinical isolates.
The study identifies a novel antibiotic resistance island, AbGRI4, in multiply antibiotic-resistant Acinetobacter baumannii clinical isolates. AbGRI4 contains a class 1 integron with aadB, aadA2, and sul1 genes, conferring resistance to aminoglycosides and sulfonamides.
Phenotypic and Genotypic Properties of Vibrio cholerae non-O1, non-O139 Isolates Recovered from Domestic Ducks in Germany.
F Plasmids Are the Major Carriers of Antibiotic Resistance Genes in Human-Associated Commensal Escherichia coli.
The study identifies various antibiotic resistance genes in commensal E. coli isolates, highlighting the prevalence of resistance genes on F plasmids and the role of mobile genetic elements in their dissemination.
Characterization of a SPM-1 metallo-beta-lactamase-producing Pseudomonas aeruginosa by comparative genomics and phenotypic analysis.
The study characterizes the multidrug-resistant Pseudomonas aeruginosa isolate CCBH4851, identifying several AMR genes including blaSPM-1, sul1, rmtD, blaOXA-56, aac(6')-I, aadA7, cmx, and bcr, as well as mutations in oprD and mexZ contributing to resistance.
Emergence of Multidrug-Resistant Salmonella enterica Subspecies enterica Serovar Infantis of Multilocus Sequence Type 2283 in German Broiler Farms.
Scarless Removal of Large Resistance Island AbaR Results in Antibiotic Susceptibility and Increased Natural Transformability in Acinetobacter baumannii.
The study shows that removing the AbaR resistance island from Acinetobacter baumannii restores antibiotic susceptibility and increases natural transformability. Several AMR genes within AbaR were identified, including aadB, aacC1, aphA1b, aacA, aadA1, strA, strB, blaVEB-1, blaOXA-10, sul1, dhfrI, dhfrX, tetA(A), tetA(G), cmlA1, cmlA5, cmlA9, catA1, arr-2, and sup.
Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study.
The study identified 55 different antimicrobial resistance determinants in diarrheal pathogens, highlighting the presence of genes conferring resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, macrolides, tetracyclines, phenicols, sulfonamides, and others. Notably, carbapenemase genes like bla OXA-48 and bla NDM were detected in certain isolates, indicating emerging resistance concerns.
Novel IncFII plasmid harbouring blaNDM-4 in a carbapenem-resistant Escherichia coli of pig origin, Italy.
The study identifies a novel IncFII plasmid, pMOL412_FII, carrying the blaNDM-4 gene, which mediates resistance to carbapenems in a carbapenem-resistant E. coli isolate from a pig in Italy. Additional resistance genes include blaTEM-1B, sul1, sul3, and dfrA12, contributing to resistance against beta-lactams, sulfamethoxazole, and trimethoprim.
First Genomic Characterization of bla(VIM-1) and mcr-9-Coharbouring Enterobacter hormaechei Isolated from Food of Animal Origin.
The study reports the first genomic characterization of a multidrug-resistant Enterobacter hormaechei isolate coharboring bla(VIM-1) and mcr-9 genes from food of animal origin. The isolate was resistant to carbapenems and other antibiotics, but susceptible to colistin. The bla(VIM-1) and mcr-9 genes were located on the same IncHI2 plasmid, along with other resistance genes.
Antibiotic Resistance Genes in Phage Particles from Antarctic and Mediterranean Seawater Ecosystems.
The study identified several antibiotic resistance genes (ARGs) in phage particles from Antarctic and Mediterranean seawater, highlighting the presence of beta-lactamase genes (bla TEM, bla CTX-M-1, bla CTX-M-9), tetracycline resistance gene (tetW), and sulfonamide resistance gene (sul1). These genes were detected in phage particles from both regions, indicating their potential role in the dissemination of antibiotic resistance.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Comparative Genomic Analysis of 450 Strains of Salmonella enterica Isolated from Diseased Animals.
The study identified 60 antimicrobial resistance genes (ARGs), 4 disinfectant resistance genes (DRGs), and 33 heavy metal resistance genes (HMRGs) in 450 Salmonella strains isolated from diseased animals. These genes contributed to resistance against multiple antimicrobial classes, including aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and phenicols.
Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam.
The study identifies multiple AMR genes in a KPC-3-producing K. pneumoniae isolate, including blaKPC-3, aac(3)-Ib, aac(6')-Ib-cr, aph(3')-Ia, blaOXA-1, blaSHV-214, mphA, qacH, catB3, arr-3, sul1, and dfrA14, which confer resistance to various antibiotics.
Pyrolyzed biowastes deactivated potentially toxic metals and eliminated antibiotic resistant genes for healthy vegetable production.
The study found that pyrolysis of biowastes effectively reduced the abundance of antibiotic resistance genes (ARGs) such as tetracycline resistance genes (tetC, tetG, tetM, tetO, tetW), sulfonamide resistance genes (sul1, sul2), and class 1 integron-integrase gene (intI1) in swine manure and sewage sludge.
Genomic analysis reveals high virulence and antibiotic resistance amongst phage susceptible Acinetobacter baumannii.
The study identified multiple antibiotic resistance genes in phage-susceptible Acinetobacter baumannii strains, including sulfonamide, tetracycline, beta-lactam, aminoglycoside, macrolide, and phenicol resistance genes. These findings highlight the complex resistance profiles of these strains and their potential implications for therapeutic strategies.
Genome Characterization of mcr-1-Positive Escherichia coli Isolated From Pigs With Postweaning Diarrhea in China.
The study identifies multiple antimicrobial resistance genes, including mcr-1.1 and mcr-3.1, in multidrug-resistant E. coli isolates from pigs with postweaning diarrhea in China.
Sewer biofilm microbiome and antibiotic resistance genes as function of pipe material, source of microbes, and disinfection: field and laboratory studies.
This study identified various antibiotic resistance genes (ARGs) in sewer biofilms, including sul1, blaTEM, tet(G), tet(O), tet(W), and ermF, which were detected in field and simulated sewer biofilm samples. The research also explored the effects of disinfection protocols on biofilm persistence.
Genomic Analysis of two NDM-1 Providencia stuartii Strains Recovered from a Single Patient.
The study identified 13 resistance genes, including beta-lactamases (blaOXA-1, blaTEM-1, blaNDM-1), aminoglycoside-modifying enzymes (aphA6, aac(3)-IId, aac(2')-Ia, aac(6')-Ib-cr5), sulfonamide resistance (sul1), chloramphenicol resistance (catB3, catA3), rifampicin resistance (arr3), bleomycin resistance (ble), and tetracycline resistance (tet(B)) in NDM-1-producing Providencia stuartii strains.
The New Klebsiellapneumoniae ST152 Variants with Hypermucoviscous Phenotype Isolated from Renal Transplant Recipients with Asymptomatic Bacteriuria-Genetic Characteristics by WGS.
The study identified several AMR genes in two hypermucoviscous Klebsiella pneumoniae isolates from renal transplant recipients, including bla CTX-M-15, aac(6')-Ib-cr, and others, indicating resistance to various antibiotics.
Can domestic pigeon be a potential carrier of zoonotic Salmonella?
The study identified several antimicrobial resistance genes in Salmonella enterica serovar Typhimurium isolated from domestic pigeons, including strB, tet(A), floR, sul1, and blaTEM-1, which confer resistance to aminoglycosides, tetracyclines, florfenicol, sulfonamides, and beta-lactams, respectively.
Biological Characteristics and Genetic Analysis of a Highly Pathogenic Proteus Mirabilis Strain Isolated From Dogs in China.
The study identified 18 antibiotic resistance genes in the multidrug-resistant Proteus mirabilis strain CC15031, including genes conferring resistance to various antibiotics such as chloramphenicol, tetracycline, aminoglycosides, beta-lactams, sulfonamides, and others.
Characteristics and Epidemiology of Extended-Spectrum β-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae From Red Kangaroo, China.
The study identified multiple AMR genes in a multidrug-resistant Klebsiella pneumoniae isolate from a Red Kangaroo, including beta-lactamases (bla DHA–3, bla SHV–1, bla CTX–M–14, bla TEM–191, bla TEM–1, bla CTX–M–3), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aac(3)-IIa, aac(6′)-Ib-cr, aadA16, arr-3), quinolone resistance genes (qnrS1, qnrB2), macrolide resistance gene (mphA), sulfonamide resistance genes (sul3, sul1), dihydrofolate reductase (dfrA3, dfrA27), chloramphenicol resistance gene (floR), tetracycline resistance genes (tetG, tetR), and multidrug efflux pump (qacEΔ1).
Pyomelanin biosynthetic pathway in pigment-producer strains from the pandemic Acinetobacter baumannii IC-5.
The study characterizes the pyomelanin biosynthetic pathway in XDR Acinetobacter baumannii strains, identifying several AMR genes including aac(6')-Ian, aac(3')-IIe, strA, strB, cmlA, sul1, bla TEM-1b, bla ADC-5, bla OXA-65, and bla OXA-23, which contribute to extensive drug resistance.
Genome-based characterization of two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases.
Two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases were characterized. The isolates exhibited resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.
A Multifactorial Approach for Surveillance of Shigella spp. and Entero-Invasive Escherichia coli Is Important for Detecting (Inter)national Clusters.
The study identified several AMR genes and mutations in Shigella spp. and EIEC isolates, including beta-lactamases (blaTEM-1b, blaOXA-1, blaCTX-M-15, blaCTX-M-32, blaCTX-M-55, blaDHA-1), dihydrofolate reductase variants (dfrA1, dfrA14, dfrA17, dfrA7, dfrA8), sulfonamide resistance genes (sul1, sul2), macrolide resistance genes (erm(B), mphA), and chromosomal mutations in gyrA, parC, and parE associated with ciprofloxacin resistance.
Employing MIC Data for Mink Pathogens to Propose Tentative Epidemiological Cut-Off Values: A Step Toward Rationalizing Antimicrobial Use in Mink.
The study identified several AMR genes in mink pathogens, including beta-lactamases (blaTEM-1, blaCTX-M-1), tetracycline resistance genes (tet(A), tet(B)), aminoglycoside resistance genes (aadA5, aadA1), sulfonamide resistance genes (sul2), dihydrofolate reductase genes (dfrA1, dfrA5, dfrA8, dfrA14), macrolide/lincosamide/streptogramin B resistance genes (erm), lincomycin resistance gene (lnu(A)), spectinomycin resistance gene (spc), and additional sulfonamide and trimethoprim resistance genes (sul1, sul3, dfrK, dfrG).
Population genomics and antimicrobial resistance in Corynebacterium diphtheriae.
The study identifies several AMR genes in Corynebacterium diphtheriae, including pbp2m associated with penicillin resistance, ermX for macrolide resistance, and various genes for tetracycline, aminoglycoside, and sulfonamide resistance.
Molecular Epidemiology of Antibiotic-Resistant Escherichia coli from Farm-To-Fork in Intensive Poultry Production in KwaZulu-Natal, South Africa.
The study identified the presence of bla CTX-M, sul1, tetA, and tetB genes in Escherichia coli isolates from various stages of the farm-to-fork continuum in intensive poultry production in South Africa.
Analysis of existence of multidrug-resistant H58 gene in Salmonella enterica serovar Typhi isolated from typhoid fever patients in Makassar, Indonesia.
Clinical and microbiological characteristics of patients colonized or infected by Stenotrophomonas maltophilia : is resistance to sulfamethoxazole/trimethoprim a problem?
The study identified the sul1, sul2, and dfrA1 genes as key mechanisms of sulfamethoxazole/trimethoprim resistance in Stenotrophomonas maltophilia, with sul1 being the most prevalent.
Isolation and molecular characterization of multidrug-resistant Escherichia coli from chicken meat.
The study identified multiple antibiotic resistance genes in multidrug-resistant E. coli isolates from chicken meat, including tetA, sul1, aadA1, ereA, aac-3-IV, cmlA, catA1, SHV, and CITM, highlighting the prevalence of resistance to various antibiotics such as tetracycline, sulfonamide, streptomycin, erythromycin, gentamicin, chloramphenicol, and beta-lactams.
Antibiotic Resistance and Virulence of Extraintestinal Pathogenic Escherichia coli (ExPEC) Vary According to Molecular Types.
The study identifies several antibiotic resistance genes (ARGs) and virulence factors (VFs) in extraintestinal pathogenic Escherichia coli (ExPEC) strains, highlighting their association with molecular types and resistance profiles.
Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid.
The study identifies the blaCTX-M-1 gene carried on an IncI1/ST3 plasmid in Enterobacter cloacae and Escherichia coli isolates from humans and wild animals in Guadeloupe, highlighting the dissemination of this resistance determinant in the environment.
Genomic and phenotypic analyses of multidrug-resistant Acinetobacter baumannii NCCP 16007 isolated from a patient with a urinary tract infection.
The study identifies multiple AMR genes and mutations in the multidrug-resistant A. baumannii NCCP 16007 strain, including pmrC, pmrB, blaOXA-23, and various aminoglycoside, tetracycline, and beta-lactam resistance genes, contributing to its high resistance to polymyxin B and other antibiotics.
Antimicrobial resistance and gene regulation in Enteroaggregative Escherichia coli from Egyptian children with diarrhoea: Similarities and differences.
The study identified multiple antibiotic resistance genes in Enteroaggregative Escherichia coli (EAEC) isolates from Egyptian children with diarrhea, including bla CTX-M-14b, bla CTX-M-15, bla TEM-1B, aadA1, aph (3')-Ib, aph (3')-Ia, aph (6)-Id, dfrA1, mdfA, sul2, and tetA, which contribute to multidrug resistance.
Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica.
The study identified several β-lactamase genes, including bla CTX-M-5, bla OXA-1, bla CTX-M-15, bla CTX-M-3, and bla TEM-1, which contribute to extended-spectrum β-lactamase (ESBL) production in multidrug-resistant non-typhoidal Salmonella enterica isolates. Additionally, a mutation in the gyrA gene (D87N) was linked to quinolone resistance.
Genomic Characterization of VIM and MCR Co-Producers: The First Two Clinical Cases, in Italy.
The study characterizes two clinical Enterobacter cloacae complex isolates co-producing VIM and MCR enzymes, identifying specific AMR genes and their resistance mechanisms.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Collateral sensitivity associated with antibiotic resistance plasmids.
The study identifies several AMR genes carried by clinically relevant plasmids, including blaOXA-48, qnrS1, blaSHV-12, aac(6')-Ib3, blaVEB-9, qnrVC-1, sul1, tetA', tetC, dfrA1, dfrA23, blaVIM-1, aadA1, qacEΔ1, blaBEL-1, blaGES-5, blaIMP-8, and blaFOX-8. These genes confer resistance to various antibiotics, and the study highlights the collateral sensitivity associated with the acquisition of these plasmids.
Virulent and multidrug-resistant Klebsiella pneumoniae from clinical samples in Balochistan.
The study identifies multidrug-resistant Klebsiella pneumoniae isolates from clinical samples in Balochistan, highlighting the presence of tetracycline resistance gene tetB, sulfonamide resistance gene Sul1, and extended-spectrum beta-lactamase gene SHV. Additionally, virulence factors fimH1 and EntB were detected.
Higher prevalence of multidrug-resistant extended-spectrum β-lactamases producing Escherichia coli in unorganized pig farms compared to organized pig farms in Mizoram, India.
The study identified several AMR genes, including bla TEM, bla CTX-M, bla CMY, tetA, tetB, sul1, sul2, aadA, and dfrIa, in multidrug-resistant E. coli isolates from both organized and unorganized pig farms in Mizoram, India.
Characterization of Enterococci- and ESBL-Producing Escherichia coli Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified several AMR genes in Enterococcus and ESBL-producing E. coli isolates from bovine mastitis cases in Egypt, including erm(B), tetL, aac-aphD, vanA, and vanB.
Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates from Jurong Lake, Singapore with Whole-Genome-Sequencing.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-8, bla CTX-M-27, bla CTX-M-14, and bla CTX-M-55, along with mcr-1.1 and mcr-3.1 for colistin resistance. Additionally, various other resistance genes such as qnrS1, mdf(A), mph(A), and others were found in the isolates, indicating multidrug resistance.
Colonization with Staphylococcus aureus and Klebsiella pneumoniae causes infections in a Vietnamese intensive care unit.
The study identifies multidrug-resistant Staphylococcus aureus ST188 and various Klebsiella pneumoniae strains with distinct resistance mechanisms, highlighting the role of colonization in causing infections in ICU patients.
Resistome of a carbapenemase-producing novel ST232 Klebsiella michiganensis isolate from urban hospital effluent in South Africa.
The study reports the first carbapenemase-producing Klebsiella michiganensis isolate from South African hospital effluent, harboring multiple resistance genes including blaOXA-181, blaOXY-5-1, qnrB6, qnrS1, aadA16, aac(6')-Ib-cr, aph(6)-Id, arr-3, sul1, sul2, dfrA14, and dfrA27.
Effects of in ovo probiotic administration on the incidence of avian pathogenic Escherichia coli in broilers and an evaluation on its virulence and antimicrobial resistance properties.
The study identified various antimicrobial resistance genes in APEC isolates, including blaTEM, aac(3)-VIa, aac(3)-VIb, aadA, tetA, tetB, dfr7, qacEΔ, qnr, sul1, intl1, arsC, and merA. These genes conferred resistance to multiple antibiotics such as beta-lactams, aminoglycosides, tetracyclines, quinolones, sulfonamides, and heavy metals.
Distribution of Beta-Lactamase Producing Gram-Negative Bacterial Isolates in Isabela River of Santo Domingo, Dominican Republic.
The study identified several beta-lactamase genes, including bla TEM, bla OXA, bla SHV, and bla KPC, as well as other resistance genes such as CTX-M-15, CTX-M-55, OXA-1, OXA-72, OXA-132, KPC-3, QnrS1, QnrB19, sul2, sul1, dfrA12, dfrA14, dfrA17, mphA, aadA, aadA2, aadA5, ampC, ampC1, ampH, PmrF, bacA, and eptA, in various Gram-negative bacterial isolates from the Isabela River in the Dominican Republic.
Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya.
The study identified several AMR genes in Salmonella isolates from Kenya, including blaTEM-1, aadA1, strA, strB, catA1, dhfr1, sul1, and sul2, which confer resistance to various antibiotics such as penicillins, cephalosporins, streptomycin, chloramphenicol, trimethoprim, and sulfonamides.
Identification of Risk Factors Associated with Resistant Escherichia coli Isolates from Poultry Farms in the East Coast of Peninsular Malaysia: A Cross Sectional Study.
The study identified several AMR genes in E. coli isolates from poultry farms in Malaysia, including aac(3)-IV, tet(A), tet(B), and sul1, which confer resistance to gentamicin, tetracyclines, and sulfonamides.
Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance.
The paper discusses the major determinants of virulence and antibiotic resistance in ESKAPE pathogens, focusing on genes such as vanA, poxtA, blaZ, mecA, blaKPC-2, blaKPC-3, armA, aacA4, aadA1, acrAB, blaCTX-M, blaGES, blaPER, blaSHV, blaTEM, blaVEB, aac(3')-Ia, ant(2’)-Ia, tetA, tetB, gyrA, parC, pmrC, pmrA, and pmrB, which are associated with resistance to various antibiotics.
Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?
The study identifies multiple AMR genes in endophytic ESBL-producing Enterobacterales isolated from fresh vegetables, highlighting their potential role in the spread of antibiotic resistance.
Genome-wide genetic marker analysis and genotyping of Escherichia fergusonii strain OTSVEF-60.
The study identified multiple antimicrobial resistance genes in Escherichia fergusonii strain OTSVEF-60, including aadA2, blaTEM-1, dfrA12, qnrS1, sul1, sul2, and tet(A), which confer resistance to aminoglycosides, beta-lactams, diaminopyrimidines, fluoroquinolones, sulfonamides, and tetracyclines.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya.
The study identified various carbapenemase genes (blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-6, blaOXA-23, blaOXA-58, blaOXA-66, blaOXA-69, blaOXA-91, blaOXA-181, blaOXA-50) and other resistance genes (such as armA, rmtC, rmtF, aac(3)-I, aadA1, aph(3')-Ia, aph(3')-VI, aph(3')-Via, aph(6')-Id, mphE, msrE, mphA, ereA, dfrA1, dfrA12, dfrA14, dfrA17, dfrA20, sul1, sul2, tetB, tetD, tetG, tet39, qnrVC1, qnrS1, qnrB4, floR, catA1, catA2, catB3, catB7, cmlA1, cmlA5, arr-3, arr-2, sat2, acrF, mdtM, emrD, mexA, mexE, mexX, kdeA, oxa-10, oxa-395, oxa-396, oxa-846, adc-25, dha-1, act-16, cmY, ctx-m-15, shv-67, tem-1b) in carbapenem non-susceptible clinical isolates of gram-negative bacteria in Kenya, highlighting the diversity and prevalence of multidrug resistance.
Molecular investigation of an outbreak associated with total parenteral nutrition contaminated with NDM-producing Leclercia adecarboxylata.
The study identified NDM-1, TEM-1B, and SHV-12 carbapenemase genes along with various other AMR genes in Leclercia adecarboxylata isolates causing an outbreak linked to contaminated TPN.
Wild Boars Carry Extended-Spectrum β-Lactamase- and AmpC-Producing Escherichia coli.
Wild boars in Germany carry ESBL/AmpC-producing E. coli, with bla CTX-M-1, bla SHV-12, and bla CMY-2 being the most common beta-lactamase genes. Additional resistance genes include sul1, sul2, sul3, dfrA1, dfrA5, dfrA14, dfrA17, tet(A), cmlA, floR, and qnrS.
Correlation between the sulfamethoxazole-trimethoprim resistance of Shigella flexneri and the sul genes.
The study found that the sul1 and sul2 genes are strongly correlated with sulfamethoxazole-trimethoprim resistance in Shigella flexneri isolates.
Institutional outbreak involving multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 at a cancer center in Tokyo, Japan.
The study identified multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 (ST78) strains causing an institutional outbreak. These strains carried blaIMP-1 and blaIMP-11 genes on IncHI2 and IncL/M plasmids, along with various other resistance genes such as aac(6')-IIc, qnrB6, fosA, sul1, and tet(B).
Deceiving Phenotypic Susceptibility Results on a Klebsiella pneumoniae Blood Isolate Carrying Plasmid-Mediated AmpC Gene bla(DHA-1).
The study identifies a carbapenem-resistant Klebsiella pneumoniae isolate carrying the plasmid-mediated AmpC gene blaDHA-1, along with other resistance genes such as blaOXA-1, aac(6')-Ib-cr, aph(3')-Ia, sul1, oqxA, oqxB, qnrB4, arr-3, tet(A), catB3, mph(A), fosA, IncFIB(K), and IncR.
Combined effects of composting and antibiotic administration on cattle manure-borne antibiotic resistance genes.
Composting reduces the relative abundance of total antibiotic resistance genes (ARGs) in manure, but certain clinically relevant ARGs like beta-lactam and sul1 remain persistent. The study highlights the impact of composting on the resistome composition and the importance of managing antibiotic use in livestock.
Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance in Escherichia coli from German Broiler Fattening Farms.
The study identified various AMR genes in E. coli isolates from German broiler farms, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-1C, blaCTX-M-1, blaCMY-2), quinolone resistance genes (qnrB19, qnrS1), chloramphenicol resistance gene (cat1), tetracycline resistance genes (tetA, tetB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase genes (drfA1, drfA5, drfA14, drfA17), aminoglycoside resistance gene (aadA1), and efflux pump genes (sugEp, qacEΔ1, mdfA).
Epidemic HI2 Plasmids Mobilising the Carbapenemase Gene bla(IMP-4) in Australian Clinical Samples Identified in Multiple Sublineages of Escherichia coli ST216 Colonising Silver Gulls.
The study identifies epidemic HI2 plasmids harboring the carbapenemase gene bla(IMP-4) in multiple sublineages of Escherichia coli ST216 isolated from Australian silver gulls, highlighting the role of these plasmids in disseminating antibiotic resistance genes.
Antimicrobial Resistance Genes and Diversity of Clones among ESBL- and Acquired AmpC-Producing Escherichia coli Isolated from Fecal Samples of Healthy and Sick Cats in Portugal.
The study identified various ESBL and qAmpC genes in E. coli isolates from cats, highlighting the presence of bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-27, bla CTX-M-9, bla TEM, bla SHV-28, and bla CMY-2, along with other resistance genes such as tet(A), tet(B), sul1, sul2, aac(6')-Ib-cr, and armA.
Clonal Clusters, Molecular Resistance Mechanisms and Virulence Factors of Gram-Negative Bacteria Isolated from Chronic Wounds in Ghana.
The study identified various AMR genes and mutations in Gram-negative bacteria isolated from chronic wounds in Ghana, including beta-lactamases, fosfomycin resistance genes, chloramphenicol resistance genes, aminoglycoside resistance genes, fluoroquinolone resistance genes, tetracycline resistance genes, sulfonamide resistance genes, trimethoprim resistance genes, and efflux pumps. Mutations in gyrA, parE, and parC were also found to contribute to fluoroquinolone resistance.
Emergence of High Level Carbapenem and Extensively Drug Resistant Escherichia coli ST746 Producing NDM-5 in Influent of Wastewater Treatment Plant, Seoul, South Korea.
The study reports the emergence of a high-level carbapenem-resistant and extensively drug-resistant (XDR) Escherichia coli strain N7 producing NDM-5, highlighting the presence of multiple resistance genes on plasmids and chromosomes.
Evaluation of commercial probiotics for antimicrobial resistance genes.
The study found that 94% of the evaluated commercial probiotics contained at least one transferable antimicrobial resistance (AMR) gene, with 82% containing two or more. The most commonly detected AMR genes were tetK (68%) and sul2 (60%).
Genomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-Producing Escherichia coli Strains From Healthy Food Animals Across Europe.
The study identifies various ESBL and AmpC beta-lactamase genes, including bla SHV-12, bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla CTX-M-15, bla TEM-52, and bla CMY-2, along with the mcr-1 gene conferring colistin resistance in E. coli isolates from food animals in Europe.
Antimicrobial Resistance Genes in ESBL-Producing Escherichia coli Isolates from Animals in Greece.
The study identified several AMR genes in ESBL-producing E. coli isolates from animals in Greece, including bla CTX-M-1/15, bla TEM, aadA1, aadA2, aphA, strA, strB, sul1, sul2, sul3, dfrA1, dfrA5, dfrA7, dfrA12, dfrA14, dfrA15, dfrA17, dfrA19, mph, mrx, intI1, tnpISE cp1, qnrS, and qnrB.
A Real-Time Thermal Sensor System for Quantifying the Inhibitory Effect of Antimicrobial Peptides on Bacterial Adhesion and Biofilm Formation.
The study identified several AMR genes in E. coli and S. aureus isolates, including beta-lactamases (blaOXA-1, blaTEM-1A), chloramphenicol acetyltransferase (catA1), trimethoprim resistance gene (dfrA1), fluoroquinolone resistance gene (floR), sulfonamide resistance genes (sul1, sul2), methicillin resistance gene (mecA), beta-lactamase (blaZ-like), and tetracycline efflux pumps (tet(K), tet(M)).
Virulence and Antimicrobial Resistance Profiles of Salmonella enterica Serovars Isolated from Chicken at Wet Markets in Dhaka, Bangladesh.
The study identified multiple antimicrobial resistance genes, including blaTEM, tetA, sul1, and strA/B, in Salmonella enterica serovars isolated from chicken at wet markets in Dhaka, Bangladesh. These genes conferred resistance to various antibiotics such as ampicillin, tetracycline, sulfamethoxazole-trimethoprim, and streptomycin.
pCTX-M3-Structure, Function, and Evolution of a Multi-Resistance Conjugative Plasmid of a Broad Recipient Range.
The study characterizes the pCTX-M3 plasmid, highlighting its role in the dissemination of antibiotic resistance genes, including bla CTX-M-3, armA, aadA2, dfrA12, sul1, and bla TEM-1. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, sulfonamides, and trimethoprim.
Frequency, Local Dynamics, and Genomic Characteristics of ESBL-Producing Escherichia coli Isolated From Specimens of Hospitalized Horses.
The study identified several ESBL genes, including blaCTX-M-1, blaCTX-M-15, blaSHV-12, blaOXA-1, blaCTX-M-14, blaCTX-M-3, and blaCMY-2, along with aminoglycoside resistance genes like aac(3)-IV, sulfonamide resistance genes sul1 and sul2, and trimethoprim resistance genes dfrA and dfrG, in ESBL-producing E. coli isolates from hospitalized horses.
Antibiotic resistance, antimicrobial residues, and bacterial community diversity in pasture-raised poultry, swine, and beef cattle manures.
The study identified the presence of antibiotic resistance genes Sul 1 and Tet A in the feces of pasture-raised poultry, swine, and beef cattle, highlighting the prevalence of these genes even in the absence of routine antibiotic use.
Genomic Identification of Multidrug-Resistant Salmonella Virchow Monophasic Variant Causing Human Septic Arthritis.
The study identifies a multidrug-resistant Salmonella Virchow monophasic variant (Salmonella 6,7,14:r:-) that exhibits resistance to chloramphenicol, tetracycline, trimethoprim, sulfamethoxazole, and nalidixic acid. The resistance is conferred by the presence of cmlA9, drfA1, sul1, tetA(G), and a gyrA(S83F) mutation.
atpD gene sequencing, multidrug resistance traits, virulence-determinants, and antimicrobial resistance genes of emerging XDR and MDR-Proteus mirabilis.
The study identified multiple antimicrobial resistance genes in XDR and MDR-Proteus mirabilis isolates from ducks, including blaTEM, blaOXA-1, blaCTX-M, tetA, sul1, blaNDM-1, and blaKPC. These genes confer resistance to various antibiotic classes such as penicillins, cephalosporins, tetracyclines, sulfonamides, and carbapenems.
Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.
The study identifies plasmid-mediated cephalosporin resistance in Salmonella Typhi isolates from India, including bla SHV-12, bla TEM-1B, bla DHA-1, qnrB7, qnrB4, aac(6')Iaa, dfrA14, sul1, and sul2 genes. Chromosomal mutations in gyrA (S83F, D87N, S80I) and parC (S80I, E84K) contribute to fluoroquinolone resistance.
Biosolids as a Source of Antibiotic Resistance Plasmids for Commensal and Pathogenic Bacteria.
Six unique resistance plasmids were identified that can transfer to Salmonella typhimurium, Klebsiella aerogenes, and E. coli, carrying 3-6 antibiotic resistance genes conferring resistance to 2-4 antibiotic classes.
Multidrug-resistant bacteria as intestinal colonizers and evolution of intestinal colonization in healthy university students in Portugal.
The study identified various AMR genes in commensal E. coli isolates from healthy university students in Portugal, including bla TEM, tetA, tetB, sul1, sul2, sul3, parC, and gyrA, indicating the presence of multidrug-resistant bacteria in the intestinal microbiota.
Evaluation of Metagenomic-Enabled Antibiotic Resistance Surveillance at a Conventional Wastewater Treatment Plant.
The study evaluated the resistome in a conventional wastewater treatment plant, identifying several antibiotic resistance genes (ARGs) such as bla OXA-210, bla OXA-212, bla OXA-309, bla OXA-333, qnr S2, sul 1, sul 2, erm B, aac (6′)-Ib7, aac (6′)-Ib8, mph D, msr E, ade J, ade K, mex K, mtr A, sme R, oqx B, qac H, and others. These genes were found to confer resistance to various antibiotics, highlighting the importance of monitoring ARGs in wastewater treatment processes.
Circulation of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli of Pandemic Sequence Types 131, 648, and 410 Among Hospitalized Patients, Caregivers, and the Community in Rwanda.
The study identifies the circulation of pandemic sequence types ST131, ST648, and ST410 of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in Rwanda, highlighting their multidrug resistance and potential for transmission among patients, caregivers, and the community.
Molecular Characterization of Multidrug-Resistant Yersinia enterocolitica From Foodborne Outbreaks in Sweden.
The study identified a chromosomally encoded multidrug-resistance cassette carrying resistance genes against chloramphenicol (catA1), streptomycin (aadA1), sulfonamides (sul1), and a mercury resistance module, as well as a 5.7-kbp plasmid with tetB encoding an ABC transporter in Yersinia enterocolitica strains from a foodborne outbreak in Sweden.
Mitigating Antibiotic Resistance Genes in Wastewater by Sequential Treatment with Novel Nanomaterials.
The study demonstrates the effectiveness of novel nanomaterials in reducing antibiotic resistance genes (ARGs) in wastewater, including bla CTXM, erm B, qnr S, sul 1, tet O, mec A, van A, and intI 1.
WGS-Based Analysis of Carbapenem-Resistant Acinetobacter baumannii in Vietnam and Molecular Characterization of Antimicrobial Determinants and MLST in Southeast Asia.
The study identified several AMR genes in carbapenem-resistant Acinetobacter baumannii strains from Vietnam, including bla OXA-51-like, bla OXA-23, bla TEM-1, and others, highlighting the widespread resistance to beta-lactams, aminoglycosides, and other antibiotics.
Diversity of Plasmids and Genes Encoding Resistance to Extended-Spectrum β-Lactamase in Escherichia coli from Different Animal Sources.
The study identified various AMR genes and mutations in E. coli isolates from different animal sources, highlighting the presence of ESBL genes such as bla CTX-M-15, bla TEM-1B, and bla CMY-28, as well as mutations in parC and gyrA that confer resistance to fluoroquinolones.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Genomic analysis and phylogenetic position of the complex IncC plasmid found in the Spanish monophasic clone of Salmonella enterica serovar Typhimurium.
The study identifies various AMR genes in the IncC plasmid pUO-STmRV1, including blaTEM-1, cmlA1, aac(3)-IV, aadA1, aadA2, sul1, sul2, sul3, tet(A), dfrA12, arsR2, arsH, merRTPCADE, and silESRCBAP, which confer resistance to antibiotics and heavy metals.
Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae.
The study identifies a conjugative plasmid p17ZR-91-Vir-KPC that encodes both carbapenem resistance and hypervirulence in Klebsiella pneumoniae, providing insight into the evolution of ST11 carbapenem-resistant and hypervirulent strains.
Metabolically Active Prokaryotes and Actively Transcribed Antibiotic Resistance Genes in Sewer Systems: Implications for Public Health and Microbially Induced Corrosion.
Three antibiotic resistance genes (sul 1, bla TEM, and tet (G)) were actively transcribed in sewer systems, indicating their potential role in antibiotic resistance. These genes were detected in sewer sediment samples, suggesting their involvement in the spread of resistance in environmental settings.
Subtypes, resistance and virulence platforms in extended-drug resistant Acinetobacter baumannii Romanian isolates.
The study identifies several AMR genes including bla OXA-23, bla OXA-24, bla OXA-51, and various aminoglycoside, sulfonamide, tetracycline, and macrolide resistance genes in XDR A. baumannii isolates from Romania.
Antibiotic Resistant and Biofilm-Associated Escherichia coli Isolates from Diarrheic and Healthy Dogs.
The study identified several AMR genes in E. coli isolates from healthy and diarrheic dogs, including blaTEM-1, qnrB, qnrS, aac(6')-Ib-cr, tetA, tetB, dfrA, sul1, sul2, int1, and tn3. These genes confer resistance to various antibiotics such as ampicillin, ciprofloxacin, tetracycline, trimethoprim, and sulfonamide.
Molecular Characterization and Survive Abilities of Salmonella Heidelberg Strains of Poultry Origin in Brazil.
The study identified the presence of bla CTX-M and bla CMY-2 genes in Salmonella Heidelberg strains, which confer resistance to various beta-lactam antibiotics. These genes were detected in 80% of the strains, highlighting the prevalence of multidrug resistance in poultry-origin Salmonella Heidelberg.
Outbreak of NDM-1-producing Klebsiella pneumoniae in the intensive care unit during the COVID-19 pandemic: Another nightmare.
The study reports an outbreak of NDM-1-producing Klebsiella pneumoniae in an ICU during the COVID-19 pandemic, highlighting the presence of multiple AMR genes including blaNDM-1, blaTEM-1, blaCTX-M-15, blaOXA-1, blaCMY-4, and others, along with mutations in ParC and GyrA contributing to quinolone resistance.
Foodborne Pathogenic Vibrios: Antimicrobial Resistance.
The paper discusses the presence of various antibiotic resistance genes in Vibrio species, including strB, sul2, tetA, blaTEM, qnrA, ermB, floR, aac(3)-IIa, blaNDM-1, blaCMY, blaP1, catB3, and others, which confer resistance to antibiotics such as streptomycin, sulfamethoxazole, tetracycline, ampicillin, fluoroquinolones, erythromycin, florfenicol, gentamicin, carbapenems, chloramphenicol, and trimethoprim.
Co-harboring of Novel bla (KPC-2) Plasmid and Integrative and Conjugative Element Carrying Tn6203 in Multidrug-Resistant Pseudomonas aeruginosa.
The study identifies a novel blaKPC-2 plasmid (pP33-2) and an integrative and conjugative element (ICEP33) carrying Tn6203 in multidrug-resistant Pseudomonas aeruginosa strains. The plasmid pP33-2 is distinct from previously reported blaKPC-2 plasmids and is not transferable. ICEP33 contains resistance genes including aac(6')-IIa, ant(2")-Ia, blaCARB-2, and sul1, contributing to multidrug resistance.
Genomic characterization of Achromobacter species isolates from chronic and occasional lung infection in cystic fibrosis patients.
The study identified several beta-lactamase genes (blaOXA-114, blaOXA-243, blaOXA-364, blaOXA-2) and other resistance genes (sul1, aac(6')-Ib) in Achromobacter species isolates, showing a species-specific distribution of blaOXA genes.
Factors associated with elevated levels of antibiotic resistance genes in sewer sediments and wastewater.
The study identified several antibiotic resistance genes (ARGs) in sewer sediments and wastewater, including sul1, tet(O), tet(W), ermF, vanA, NDM-1, mcr-1, and mecA, highlighting the potential for ARG proliferation in sewer environments.
Antimicrobial Resistance Spectrum Conferred by pRErm46 of Emerging Macrolide (Multidrug)-Resistant Rhodococcus equi.
The study characterizes the antimicrobial resistance spectrum conferred by the pRErm46 plasmid in multidrug-resistant Rhodococcus equi, identifying genes erm(46), sul1, aadA9, and tetRA(33) that confer resistance to macrolides, lincosamides, streptogramin B, sulfonamides, streptomycin, spectinomycin, and tetracycline. Additionally, rpoB mutations (Ser531Phe, Ser531Leu, Ser531Tyr) were found to confer resistance to rifampin.
Prevalence and mechanisms of antibiotic resistance in Escherichia coli isolated from mastitic dairy cattle in Canada.
The study identified several AMR genes in E. coli isolates from bovine mastitis, including beta-lactamases (blaTEM-1, blaCARB-3, blaCMY-59), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aadA2), and multidrug efflux pump genes (acrA, acrB, acrD, tolC, baeR, emrA, emrB).
The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries.
The study identified multiple AMR genes and mutations in invasive non-typhoidal Salmonella isolates from sub-Saharan Africa, highlighting the prevalence of multidrug resistance.
Genomic insights into the antibiotic resistance pattern of the tetracycline-degrading bacterium, Arthrobacter nicotianae OTC-16.
The study identifies several antibiotic resistance genes in Arthrobacter nicotianae OTC-16, including ant2ia, sul1, tet33, cml_e8, and tetV, which confer resistance to various antibiotics such as tetracyclines, sulfonamides, aminoglycosides, and chloramphenicol.
Interaction of Acinetobacter baumannii with Human Serum Albumin: Does the Host Determine the Outcome?
The study identified several antibiotic resistance genes in Acinetobacter baumannii, including clmA, pbp1, pbp3, blaPER-7, aac(6a)-Ib, ant(2n)-Ia, armA, aphA6, sul1, and arr2, which were upregulated or downregulated in response to human serum albumin (HSA) and human serum (HS).
Two carbapenem-resistant ST1:ST231:KL1:OCL1 Acinetobacter baumannii strains recovered in Tehran, Iran, carry AbaR31 in the chromosome and AbaR4 and TnaphA6 in a RepAci6 plasmid.
The study identifies multiple antibiotic resistance genes, including catA1, tetA(A), sul1, aacC1, aadA1, aphA6, and oxa23, in two carbapenem-resistant Acinetobacter baumannii strains, ABH008 and ABS200, highlighting their extensive drug resistance.
Honeybee Exposure to Veterinary Drugs: How Is the Gut Microbiota Affected?
The study identified tetracycline resistance genes tetW and tetY, and sulfonamide resistance genes sul1 and sul2 in the honeybee gut microbiota, which increased in abundance following antibiotic treatment.
Antibiotic-resistant bacteria, antibiotic resistance genes, and antibiotic residues in wastewater from a poultry slaughterhouse after conventional and advanced treatments.
The study identified several antibiotic resistance genes (ARGs) in wastewater from a poultry slaughterhouse, including bla TEM, bla CTX-M-1, bla SHV-12, mcr-1, ermB, sul1, tetM, bla OXA-48, bla CMY-2, and vanA. These genes were found to confer resistance to various antibiotics such as beta-lactams, macrolides, sulfonamides, tetracyclines, carbapenems, and glycopeptides.
Genomic insights into the diversity, virulence and resistance of Klebsiella pneumoniae extensively drug resistant clinical isolates.
The study identified various beta-lactamase genes, including blaSHV-11, blaKPC-2, and blaNDM-1, along with qnrS1, aadA1, dfrA1, and sul1, which contribute to multidrug resistance in extensively drug-resistant Klebsiella pneumoniae isolates.
Genetic Features of Plasmid- and Chromosome-Mediated mcr-1 in Escherichia coli Isolates From Animal Organs With Lesions.
The study characterizes the mcr-1 gene and various other resistance genes in Escherichia coli isolates from animal organs with lesions, highlighting their multidrug resistance profiles and the genetic features of plasmids carrying these genes.
Emergence and Genetic Characterization of Plasmid-Encoded VIM-2-Producing Pseudomonas stutzeri with Novel Integron In1998 Isolated from Cerebrospinal Fluid.
The study identifies a novel plasmid-encoded VIM-2-producing Pseudomonas stutzeri strain, ZDHY95, with a complex genetic arrangement including a novel class I integron In1998 and various resistance genes such as blaVIM-2, aacA3, aadA13, cmlA8, blaOXA-246, arr3, dfrA27, qacEΔ1, sul1, aacA4'-30, aacA4', qnrVC1, catB11, blaCARB-4.
Metagenomic analysis of MWWTP effluent treated via solar photo-Fenton at neutral pH: Effects upon microbial community, priority pathogens, and antibiotic resistance genes.
Solar photo-Fenton treatment effectively removed a wide range of antibiotic resistance genes (ARGs) including those conferring resistance to sulfonamides, macrolides, tetracyclines, and beta-lactams. The study identified several ARGs such as sul1, sul2, tet(X), erm(F), mph(A), mph(E), msr(E), aadA, aph(3"), aph(6), strA, and blaBKC.
Climatological and Epidemiological Conditions Are Important Factors Related to the Abundance of bla(KPC) and Other Antibiotic Resistance Genes (ARGs) in Wastewater Treatment Plants and Their Effluents, in an Endemic Country.
The study identified the prevalence of antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs) in Colombia, highlighting the significant presence of bla KPC, sul 1, sul 2, erm B, and others. It also found that environmental factors such as dissolved oxygen and precipitation correlate with the abundance of these genes.
Climatological and Epidemiological Conditions Are Important Factors Related to the Abundance of bla(KPC) and Other Antibiotic Resistance Genes (ARGs) in Wastewater Treatment Plants and Their Effluents, in an Endemic Country.
The study identified the prevalence of antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs) in Colombia, highlighting the significant presence of bla KPC, sul 1, sul 2, erm B, and others. It also found that environmental factors such as dissolved oxygen and precipitation correlate with the abundance of these genes.
Whole Genome Sequencing of Pediatric Klebsiella pneumoniae Strains Reveals Important Insights Into Their Virulence-Associated Traits.
The study identified various AMR genes in K. pneumoniae strains, including beta-lactamases (blaSHV, blaOXA, blaTEM, blaCTX-M), fosfomycin resistance (fosA), quinolone resistance (oqxA, qnrB), chloramphenicol resistance (catB3), aminoglycoside resistance (aac(3), aadA1, strB), sulfonamide resistance (sul1), trimethoprim resistance (dfrA), and tetracycline resistance (tet(A)).
Genomic Investigation of Antimicrobial-Resistant Salmonella enterica Isolates From Dead Chick Embryos in China.
The study identified several AMR genes in Salmonella enterica isolates from dead chick embryos in China, including aac(6')-Iaa, qnrB4, bla, and sul1, which confer resistance to various antibiotics.
Antimicrobial Resistance and Whole-Genome Characterisation of High-Level Ciprofloxacin-Resistant Salmonella Enterica Serovar Kentucky ST 198 Strains Isolated from Human in Poland.
The study identified several AMR genes and mutations in high-level ciprofloxacin-resistant Salmonella Enterica serovar Kentucky ST198 strains isolated from humans in Poland, including blaTEM-1B, qnrS1, aac(3)-Id, aac(3)-IId, aac(6')-Iaa, aac(6')-Iid, aph(3")-Ib, aph(3")-Id, aadA1, sul1, dfrA1, and tetA, along with mutations in gyrA and parC that confer resistance to quinolones and beta-lactams.
Genetic Diversity of Multidrug-Resistant Pseudomonas aeruginosa Isolates Carrying bla (VIM-2) and bla (KPC-2) Genes That Spread on Different Genetic Environment in Colombia.
The study identifies bla(VIM-2) and bla(KPC-2) genes in multidrug-resistant Pseudomonas aeruginosa isolates from Colombia, highlighting their diverse genetic environments and mechanisms of resistance.
Discerning the Antimicrobial Resistance, Virulence, and Phylogenetic Relatedness of Salmonella Isolates Across the Human, Poultry, and Food Materials Sources in Malaysia.
The study identified several AMR genes in Salmonella Enteritidis isolates from Malaysia, including aac(6')-ly, blaCMY-2, blaTEM-1, blaTEM-33, blaTEM-4, dfrA14, dfrA15, floR, qnrS1, qnrD1, sul1, sul2, strA, strB, tetA, and tetC. These genes conferred resistance to various antibiotics such as gentamicin, ampicillin, chloramphenicol, ciprofloxacin, sulfamethazine/trimethoprim, and tetracycline.
Multidrug-Resistant Lineage of Enterotoxigenic Escherichia coli ST182 With Serotype O169:H41 in Airline Waste.
The study identifies multidrug-resistant E. coli ST182 isolates from airline waste carrying genes such as blaCTX-M-15, qnrS1, aadA5, mphA, sul1, and dfrA17, along with the S83L mutation in gyrA, contributing to resistance against multiple antibiotics.
Prevalence, antibiotic susceptibility, and presence of drug resistance genes in Aeromonas spp. isolated from freshwater fish in Kelantan and Terengganu states, Malaysia.
The study identified multiple antibiotic resistance genes in Aeromonas spp. isolated from freshwater fish in Malaysia, including blaTEM, blaSHV, sul1, aadA, strA-strB, tetA, and tetE, which confer resistance to ampicillin, sulfamethoxazole, streptomycin, and tetracycline.
Occurrence of Colibacillosis in Broilers and Its Relationship With Avian Pathogenic Escherichia coli (APEC) Population Structure and Molecular Characteristics.
The study identified multiple antimicrobial resistance genes in Avian Pathogenic Escherichia coli (APEC) isolates, including beta-lactamases (blaCMY-2, blaSHV-12, blaTEM-52, blaCTX-M-1), aminoglycoside resistance genes (aac(3)-IV, aadA, strA, strB, aph(3')-Ib), sulfonamide resistance gene (sul1), tetracycline resistance genes (tet(A), tet(B)), trimethoprim resistance gene (dfrA), quinolone resistance genes (qnrS1, qnrS2, qnrB19), macrolide resistance genes (mph(A), mph(B)), and chloramphenicol resistance gene (catA1).
Antimicrobial Resistance Patterns and Risk Factors Associated with Salmonella spp. Isolates from Poultry Farms in the East Coast of Peninsular Malaysia: A Cross-Sectional Study.
The study identified multiple antimicrobial resistance genes in Salmonella spp. isolates from poultry farms in Malaysia, including blaTEM, tet(A), tet(B), catA1, cat2, floR, sul1, and sul2, which confer resistance to beta-lactams, tetracyclines, chloramphenicol, and sulfonamides.
Antimicrobial Resistance and Type III Secretion System Virulotypes of Pseudomonas aeruginosa Isolates from Dogs and Cats in Primary Veterinary Hospitals in Japan: Identification of the International High-Risk Clone Sequence Type 235.
The study identifies various AMR genes and mutations in P. aeruginosa isolates from dogs and cats in Japan, highlighting the presence of high-risk clones like ST235 and the role of genetic factors in carbapenem and fluoroquinolone resistance.
Aerobactin Seems To Be a Promising Marker Compared With Unstable RmpA2 for the Identification of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae: In Silico and In Vitro Evidence.
The study identifies aerobactin as a stable and functional marker for the identification of hypervirulent carbapenem-resistant Klebsiella pneumoniae (CR-hvKp), highlighting the instability of RmpA2 and the importance of molecular identification due to the limitations of phenotypic screening.
Insight Into Whole Genome of Aeromonas veronii Isolated From Freshwater Fish by Resistome Analysis Reveal Extensively Antibiotic Resistant Traits.
The study identified 17 AMR genes in Aeromonas veronii isolates from tilapia, highlighting extensive antibiotic resistance traits, including resistance to beta-lactams, aminoglycosides, tetracyclines, and others.
A genomic epidemiological study shows that prevalence of antimicrobial resistance in Enterobacterales is associated with the livestock host, as well as antimicrobial usage.
The study identified various AMR genes in Enterobacterales isolates from livestock, highlighting the association between AMR prevalence and antimicrobial usage, with pigs being a major reservoir of AMR genes.
IS1294 Reorganizes Plasmids in a Multidrug-Resistant Escherichia coli Strain.
The study identifies and characterizes various AMR genes, including blaCTX-M-55, rmtB, oqxAB, blaTEM-1b, floR, tet(A), strA, strB, sul1, sul2, aac(3)-IId, aadA2, dfrA12, and aph(3′)-IIa, in a multidrug-resistant E. coli strain. These genes contribute to resistance against multiple antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, tetracyclines, sulfonamides, and trimethoprim.
Biological Mitigation of Antibiotic Resistance Gene Dissemination by Antioxidant-Producing Microorganisms in Activated Sludge Systems.
The study demonstrates that antioxidant-producing microorganisms, such as Deinococcus radiodurans R1 and Rhodotorula sp., can mitigate the dissemination of antibiotic resistance genes (ARGs) in activated sludge systems by reducing the persistence of plasmid RP4 and the enrichment of sul1 and intl1. These microorganisms also decrease the diversity of ARG hosts and limit the conjugative transfer of ARGs.
Characterization of a pESI-like plasmid and analysis of multidrug-resistant Salmonella enterica Infantis isolates in England and Wales.
The study characterizes a pESI-like plasmid harboring multiple resistance genes, including bla CTX-M-65, in multidrug-resistant Salmonella enterica Infantis isolates from England and Wales. The plasmid was associated with resistance to beta-lactams, aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, sulfonamides, fosfomycin, and heavy metals.
Use of Molecular Methods To Detect Shigella and Infer Phenotypic Resistance in a Shigella Treatment Study.
The study identified several AMR genes including ermB, mphA, blaTEM, blaCTX-M1, blaDHA, blaOXA-1, dfrA, and sul in Shigella isolates. Mutations in gyrA (83L) and parC (80I) were associated with ciprofloxacin resistance.
International High-Risk Clones Among Extended-Spectrum β-Lactamase-Producing Escherichia coli in Dhaka, Bangladesh.
The study identified several AMR genes and mutations in ESBL-producing E. coli isolates from Dhaka, Bangladesh, including bla CTX-M-15, bla NDM-5, mcr-1, and various aminoglycoside resistance genes. Mutations in gyrA and parC were also associated with fluoroquinolone resistance.
Genomic Analysis of Ciprofloxacin-Resistant Salmonella enterica Serovar Kentucky ST198 From Spanish Hospitals.
The study identified several AMR genes and mutations associated with ciprofloxacin resistance in Salmonella enterica serovar Kentucky ST198 isolates from Spanish hospitals. Key findings include the presence of blaTEM-1B, aacA5, aadA7, sul1, tet(A), catA1, and aac(6′)-Ib genes, along with mutations in gyrA (Ser83Phe) and parC (Thr57Ser, Ser80Ile).
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms.
The study identified several ESBL genes, colistin resistance genes, and other AMR genes in ESBL-producing E. coli from pigs and pig farm workers in Vietnam. Key findings include the prevalence of bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27, along with mcr-1 and mcr-3 for colistin resistance, and various other resistance genes for aminoglycosides, quinolones, tetracyclines, chloramphenicol, macrolides, and sulfonamides.
Identification of Three Novel PmGRI1 Genomic Resistance Islands and One Multidrug Resistant Hybrid Structure of Tn7-like Transposon and PmGRI1 in Proteus mirabilis.
The study identifies three novel variants of PmGRI1 and a hybrid structure combining Tn7-like transposon and PmGRI1 in Proteus mirabilis, highlighting their role in carrying multiple antibiotic resistance genes.
Antibiotic resistance genes in layer farms and their correlation with environmental samples.
The study identified and quantified 13 antibiotic resistance genes (ARGs) in layer manure, layer manure fertilizer, and soil samples from Guangdong Province, highlighting the high prevalence and abundance of these genes, particularly ermB, tetA, and sul2, and their potential environmental impact.
Whole-Genomic Analysis of NDM-5-Producing Enterobacteriaceae Recovered from an Urban River in China.
The study identified multiple antimicrobial resistance genes, including bla NDM-5, bla OXA-10, and bla TEM-1B, in NDM-5-producing Enterobacteriaceae isolates from an urban river in China. These genes conferred resistance to various antibiotics such as carbapenems, cephalosporins, quinolones, and aminoglycosides.
Co-occurrence of Klebsiella variicola and Klebsiella pneumoniae Both Carrying bla (KPC) from a Respiratory Intensive Care Unit Patient.
The study identified Klebsiella variicola and Klebsiella pneumoniae strains carrying multiple resistance genes, including bla KPC-2, bla TEM-1A, bla LEN17, aadA16, arr-3, qnrB4, oqxA/B, dfrA27, sul1, tetD, fosA, qacEΔ1, bla CTX-M-3, bla TEM-1B, bla CTX-M-65, bla SHV-27, aac(6')-IIa, rmtB, aph(3')-Ia, aadA16, qnrS1, aac(6')-Ib-cr, qnrB91, oqxA/B, mph(A), tet(A), fosA, dfrA27, and two copies of qacEΔ1-sul1.
Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units.
The study evaluated the use of respiratory metagenomics to detect antimicrobial resistance genes and improve treatment of secondary infections in ICU patients. It identified several beta-lactam resistance genes, macrolide resistance genes, and sulfonamide resistance genes in various bacterial species.
Deciphering Multidrug-Resistant Acinetobacter baumannii from a Pediatric Cancer Hospital in Egypt.
The study identified various AMR genes and mutations in multidrug-resistant Acinetobacter baumannii isolates from a pediatric cancer hospital in Egypt, highlighting the presence of bla NDM, bla OXA-23-like, bla OXA-51-like, and other resistance genes, along with mutations in pmrA and lptF contributing to colistin resistance.
The First Saudi Study Investigating the Plasmid-borne Aminoglycoside and Sulfonamide Resistance among Acinetobacter baumannii Clinical Isolates Genotyped by RAPD-PCR: the Declaration of a Novel Allelic Variant Called aac(6')-SL and Three Novel Mutations in the sul1 Gene in the Acinetobacter Plasmid (s).
The study identified a novel allelic variant of aac(6')-Ib called aac(6')-SL and three novel mutations in the sul1 gene among Acinetobacter baumannii clinical isolates in Saudi Arabia.
Invasive atypical non-typhoidal Salmonella serovars in The Gambia.
The study identified several antimicrobial resistance genes in invasive Salmonella serovars in The Gambia, including blaTEM-1B, aph(3'')-Ib, aph(6)-Id, catA1, dfrA7, sul1, sul2, tet(B), and fosA7. These genes conferred resistance to various antibiotics such as ampicillin, penicillin, gentamicin, kanamycin, tobramycin, chloramphenicol, trimethoprim, sulfamethoxazole, tetracycline, and fluoroquinolones.
Stepwise Evolution of a Klebsiella pneumoniae Clone within a Host Leading to Increased Multidrug Resistance.
The study identifies the acquisition of multiple AMR genes and mutations in a Klebsiella pneumoniae clone, leading to increased multidrug resistance. Key findings include the role of blaCTX-M-14, aac(3)-Iid, tet(A), qnrS1, sul1, dfrA1, acrAB-TolC, ompK35, and mgrB in conferring resistance to various antibiotics, along with mutations in ramR that contribute to resistance.
Co-conjugation of Virulence Plasmid and KPC Plasmid in a Clinical Klebsiella pneumoniae Strain.
The study characterizes a carbapenem-resistant hypervirulent Klebsiella pneumoniae strain that harbors a conjugative virulence plasmid and a bla KPC–2-bearing plasmid. The virulence plasmid contains multiple resistance genes, including bla KPC–2, qnrB4, bla DHA–1, sul1, msr(E), mph(E), bla TEM–1B, aac(3)-IId, bla SHV–12, mph(A), bla CTX–M–65, bla TEM–1B, fosA3, and rmtB. The study also shows that these plasmids can be transferred to other bacterial strains, contributing to the spread of multidrug-resistant and hypervirulent K. pneumoniae.
CRISPR Element Patterns vs. Pathoadaptability of Clinical Pseudomonas aeruginosa Isolates from a Medical Center in Moscow, Russia.
The study identified multiple antibiotic resistance genes in clinical Pseudomonas aeruginosa isolates, including blaVIM-2, blaOXA-396, blaOXA-488, floR, tetG, sul1, dfrA5, dfrB2, dfrB5, aph(3)-Ib, blaPAO, catB7, and fosA, which confer resistance to various antibiotics such as beta-lactams, chloramphenicol, tetracycline, sulfonamides, trimethoprim, aminoglycosides, and fosfomycin.
Antimicrobial Susceptibility and Detection of Virulence-Associated Genes in Escherichia coli Strains Isolated from Commercial Broilers.
The study identified several AMR genes in E. coli strains from commercial broilers, including bla CTX-M-1 and bla CTX-M-2 for cephalosporin resistance, qnrA, qnrB, qnrS for fluoroquinolone resistance, aac(6')-Ib-cr for fluoroquinolone and aminoglycoside resistance, tetA and tetB for tetracycline resistance, sul1 and sul2 for sulfonamide resistance, aadA for aminoglycoside resistance, dfrA and dfrB for trimethoprim resistance, and mcr1 and mcr2 for polymyxin resistance.
Impact of Antibiotic Therapies on Resistance Genes Dynamic and Composition of the Animal Gut Microbiota.
The study examined the impact of antibiotic therapies on the dynamics and composition of resistance genes in the animal gut microbiota, identifying several AMR genes such as blaTEM, tetA, strA, strB, intI1, tetM, mel, floR, mcr-2, oqx B, tetC, tetG, tetO, tetW, tetX, ermB, ermF, sul1, sul2, and others, which were experimentally validated in Escherichia coli.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Colistin Resistance Onset Strategies and Genomic Mosaicism in Clinical Acinetobacter baumannii Lineages.
The study identifies various AMR genes and mutations associated with colistin resistance in clinical Acinetobacter baumannii strains, highlighting the genomic diversity and mosaicism in resistance mechanisms.
Phage Cocktail Development against Aeromonas salmonicida subsp. salmonicida Strains Is Compromised by a Prophage.
The study identifies antibiotic resistance genes such as sul1, sul2, floR, tetA, and cat in Aeromonas salmonicida subsp. salmonicida strains, highlighting their role in resistance to sulfonamides, chloramphenicol, and tetracycline. It also shows that the presence of Prophage 3 reduces the effectiveness of phage cocktails against these strains.
Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Strains Isolated at the German Military Field Laboratory in Mazar-e Sharif, Afghanistan.
The study identified bla OXA-23 as the primary cause of carbapenem resistance in Acinetobacter baumannii isolates from Afghanistan, along with various other resistance genes for sulfonamides, macrolides, tetracyclines, and aminoglycosides.
Comparison of antimicrobial resistance and molecular characterization of Escherichia coli isolates from layer breeder farms in Korea.
The study identified several AMR genes in E. coli isolates from layer breeder farms in Korea, including bla TEM-1, tetA, tetB, qnrB, qnrS, sul1, sul2, aac(3)-II, and aac(6')-Ib. These genes conferred resistance to various antibiotics such as beta-lactams, tetracyclines, quinolones, sulfonamides, and aminoglycosides.
High-Resolution Genomic Profiling of Carbapenem-Resistant Klebsiella pneumoniae Isolates: A Multicentric Retrospective Indian Study.
The study identifies various carbapenem resistance genes such as blaOXA232, blaNDM1, blaNDM5, blaOXA181, and others in Klebsiella pneumoniae isolates from India. It also characterizes mutations in ompK35 and ompK36 contributing to carbapenem resistance.
Genome Sequencing Identifies Previously Unrecognized Klebsiella pneumoniae Outbreaks in Neonatal Intensive Care Units in the Philippines.
The study identified several AMR genes, including bla CTX-M-15, bla NDM-1, rmtC, aac(6')-Ib, aac(3)-II, aph(3′′)-Ib, oqxA, oqxB, qnrB1, qnrS1, sul1, sul2, and dfrA, which were associated with resistance to various antibiotics in Klebsiella pneumoniae isolates from the Philippines.
Mouse pneumonia model by Acinetobacter baumannii multidrug resistant strains: Comparison between intranasal inoculation, intratracheal instillation and oropharyngeal aspiration techniques.
The study identified various AMR genes in two multidrug-resistant Acinetobacter baumannii strains, ACC001 and ACC002, including aminoglycoside resistance genes, tetracycline resistance genes, beta-lactamases, and sulfonamide resistance genes. These genes contribute to resistance against multiple antibiotics such as gentamicin, tobramycin, tetracycline, penicillins, cephalosporins, and sulfonamides.
Carbapenem-Resistant Citrobacter spp. as an Emerging Concern in the Hospital-Setting: Results From a Genome-Based Regional Surveillance Study.
The study identifies various carbapenemase genes, including bla KPC-2, bla OXA-48, bla VIM-1, bla NDM-5, bla OXA-162, and bla KPC-3, in Citrobacter spp. isolates, highlighting their role in carbapenem resistance.
Genomic Characterization of Extensively Drug-Resistant NDM-Producing Acinetobacter baumannii Clinical Isolates With the Emergence of Novel bla (ADC-257).
The study identified several AMR genes, including novel bla ADC-257, and mutations in gyrA and parC associated with fluoroquinolone resistance in extensively drug-resistant NDM-producing Acinetobacter baumannii isolates.
Genomic diversity of antimicrobial resistance in non-typhoidal Salmonella in Victoria, Australia.
The study identified various AMR genes and mutations in non-typhoidal Salmonella, including bla TEM-1, bla TEM-135, strAB, sul1, sul2, tet(A), tet(B), floR, bla CMY-2, bla CTX-M-55, and bla CTX-M-65, along with mutations in gyrA and parC contributing to ciprofloxacin resistance.
Genomic comparisons of Escherichia coli ST131 from Australia.
The study identifies multiple AMR genes and mutations in Australian E. coli ST131 isolates, including bla CTX-M-15 and bla CTX-M-27 for beta-lactam resistance, aadA5, strA, strB, mphA, dfrA17, sul1, qacEΔ1, and chrA for resistance to aminoglycosides, macrolides, trimethoprim, sulfonamides, quaternary ammonium compounds, and chromate. Fluoroquinolone resistance mutations in gyrA and parC were also found.
Letter to the Editor: Importation of the First Bovine ST361 New Delhi Metallo-5 Positive Escherichia coli in Greece.
The study reports the first bovine ST361 NDM-5 positive Escherichia coli in Greece, highlighting the importation of multidrug-resistant strains and the need for continued surveillance.
Pan-Resistome Characterization of Uropathogenic Escherichia coli and Klebsiella pneumoniae Strains Circulating in Uganda and Kenya, Isolated from 2017-2018.
The study identified various AMR genes in uropathogenic E. coli and K. pneumoniae strains from Uganda and Kenya, highlighting the prevalence of multidrug-resistant (MDR) and extended-spectrum beta-lactamase (ESBL)-producing strains.
Characterization of Oral Enterobacteriaceae Prevalence and Resistance Profile in Chronic Kidney Disease Patients Undergoing Peritoneal Dialysis.
The study identified several antibiotic resistance genes, including sul1, intI1, bla CTX-M, and bla SHV, in Enterobacteriaceae isolates from chronic kidney disease patients undergoing peritoneal dialysis. These genes were associated with resistance to sulfamethoxazole, cephalothin, ceftazidime, meropenem, ampicillin, and cefotaxime.
Performance evaluation of ozonation for removal of antibiotic-resistant Escherichia coli and Pseudomonas aeruginosa and genes from hospital wastewater.
The study evaluated the effectiveness of ozonation in removing antibiotic-resistant bacteria and genes from hospital wastewater, identifying several AMR genes including bla_tem, bla_ctx, bla_vim, sul1, and qnrS.
Genomic evolution of the globally disseminated multidrug-resistant Klebsiella pneumoniae clonal group 147.
The study identifies multiple AMR genes and mutations in the pandrug-resistant K. pneumoniae strain DJ, including carbapenemases (bla NDM-5, bla OXA-181, bla CTX-M-15), aminoglycoside resistance genes (rmtB, rmtF, aac(6')-Ib, aadA2, strAB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase (dfrA12), polymyxin resistance gene (mgrB), tetracycline resistance gene (ramR), chloramphenicol resistance genes (catA2, catB), fosfomycin resistance gene (fosA), and macrolide resistance genes (mphA, ermB). Mutations in gyrA, parC, ompK35, ompK36, and ramR contribute to resistance to fluoroquinolones, polymyxins, tetracyclines, and other antibiotics.
The Genomic Characterization of KPC-Producing Klebsiella pneumoniae from the ICU of a Teaching Hospital in Shanghai, China.
The study identified the carbapenemase gene blaKPC-2 and blaKPC-24, along with fosfomycin resistance gene fosA6, and various extended-spectrum beta-lactamase genes such as blaCTX-M-15, blaCTX-M-65, and blaCTX-M-27 in KPC-producing Klebsiella pneumoniae strains. Additionally, genes associated with fluoroquinolone, macrolide, aminoglycoside, and sulfonamide resistance were also characterized.
Occurrence of NDM-1, VIM-1, and OXA-10 Co-Producing Providencia rettgeri Clinical Isolate in China.
The study reports a Providencia rettgeri clinical isolate co-harboring blaNDM-1, blaVIM-1, and blaOXA-10, which conferred resistance to multiple antibiotics including carbapenems, ceftazidime-avibactam, and aminoglycosides.
One Health Genomic Study of Human and Animal Klebsiella pneumoniae Isolated at Diagnostic Laboratories on a Small Caribbean Island.
The study identified various AMR genes in Klebsiella pneumoniae isolates from humans and animals on St. Kitts, including bla CTX-M-15, bla TEM-1b, bla TEM-206, bla OXA-1, and others, highlighting host-specific differences in resistance profiles.
Antimicrobial Susceptibility Profiles among Pseudomonas aeruginosa Isolated from Professional SCUBA Divers with Otitis Externa, Swimming Pools and the Ocean at a Diving Operation in South Africa.
The study identified multiple beta-lactamase genes (blaAmpC, blaTEM, blaOxa-4, CTX-M1, blaSHV), sulfonamide resistance genes (sul1, sul2), and integron genes (IntI1, IntI2) in P. aeruginosa isolates from SCUBA divers, swimming pools, and the ocean in Sodwana Bay, South Africa, indicating a high level of multidrug resistance.
The Darkest Place Is under the Candlestick-Healthy Urogenital Tract as a Source of Worldwide Disseminated Extraintestinal Pathogenic Escherichia coli Lineages.
The study identified several AMR genes and mutations in E. coli strains from the urogenital microbiome of healthy women, including blaTEM-30, tet(A), aac(3)-IId, sul1, dfrA12, and a gyrA mutation (S83L) conferring resistance to various antibiotics.
Comparative Whole-Genome Analysis of Russian Foodborne Multidrug-Resistant Salmonella Infantis Isolates.
The study identified multiple AMR genes in multidrug-resistant Salmonella Infantis isolates, including aac(6')-Iaa, ant(3")-Ia, tetABD, sul123, dfrA14, and blaCTX-M-14, which contribute to resistance against aminoglycosides, tetracycline, sulfonamides, trimethoprim, and cephalosporins.
Plethora of Resistance Genes in Carbapenem-Resistant Gram-Negative Bacteria in Greece: No End to a Continuous Genetic Evolution.
The study identified a variety of resistance genes in carbapenem-resistant Gram-negative bacteria, including bla KPC, bla NDM, bla VIM, and others, highlighting the complex genetic diversity of these pathogens.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
Genomic Characterization of Carbapenem-Non-susceptible Pseudomonas aeruginosa Clinical Isolates From Saudi Arabia Revealed a Global Dissemination of GES-5-Producing ST235 and VIM-2-Producing ST233 Sub-Lineages.
The study identified GES-5-producing ST235 and VIM-2-producing ST233 sub-lineages of Pseudomonas aeruginosa in Saudi Arabia, highlighting their global dissemination and the presence of various resistance genes including blaGES-5, blaVIM-2, and others.
Genomic features of a multidrug-resistant and mercury-tolerant environmental Escherichia coli recovered after a mining dam disaster in South America.
The study identifies a multidrug-resistant Escherichia coli strain (B2C) carrying the bla CTX-M-2 ESBL gene, qacE∆1 efflux pump, and the mer operon, indicating resistance to antibiotics, heavy metals, and disinfectants.
Virulence and antimicrobial resistance profile of non-typhoidal Salmonella enterica serovars recovered from poultry processing environments at wet markets in Dhaka, Bangladesh.
The study identified several AMR genes in non-typhoidal Salmonella enterica serovars from poultry processing environments in Bangladesh, including bla TEM, tet A, sul 1, and str A/B, which conferred resistance to various antibiotics such as ampicillin, tetracycline, sulfamethoxazole-trimethoprim, and streptomycin.
S. algae as a reservoir and a vehicle of potential antimicrobial resistance
The study identified multiple antimicrobial resistance genes in S. algae strains, including genes conferring resistance to beta-lactams, aminoglycosides, quinolones, phenicols, macrolides, sulfonamides, tetracyclines, and lincosamides.
Advanced Oxidation Processes for Inactivation of Antibiotic Resistance Genes in Wastewater
The paper discusses the fate of antibiotic resistance genes (ARGs) during wastewater treatment processes, highlighting the inefficiency of conventional methods in removing ARGs and the potential of UV and chlorine-based advanced oxidation processes (AOPs) for inactivating ARGs. It emphasizes the need for improved wastewater treatment strategies to mitigate the spread of antibiotic resistance.
Genome Informatics and Machine Learning-Based Identification of Antimicrobial Resistance-Encoding Features and Virulence Attributes in Escherichia coli Genomes Representing Globally Prevalent Lineages, Including High-Risk Clonal Complexes.
The study identified 247 AMR genes across 19 STs of E. coli, including beta-lactamases (ampC, blaTEM-4), quinolone resistance (qnrS1), sulfonamide resistance (sul1, sul2), and efflux pumps (emrE, floR).
Genomic Analysis of ESBL-Producing E. coli in Wildlife from North-Eastern Germany.
The study identified ESBL-producing E. coli in wild boar and wild ruminants with a low prevalence. The most prevalent ESBL type was CTX-M-1. The study also found resistance genes for aminoglycosides, phenicol, sulfonamides, and tetracyclines.
Similarities in Virulence and Extended Spectrum Beta-Lactamase Gene Profiles among Cefotaxime-Resistant Escherichia coli Wastewater and Clinical Isolates.
The study identifies several beta-lactamase genes, including blaCTX-M-1, blaKPC-2, blaTEM-350, blaOXA-1, and blaCTX-M-15, as well as various aminoglycoside, macrolide, and tetracycline resistance genes in cefotaxime-resistant E. coli isolates from hospital and urban wastewater. Mutations in parC, parE, and gyrA contribute to fluoroquinolone resistance.
Detection of Carbapenem Resistance of Proteus mirabilis Strains Isolated from Foxes, Raccoons and Minks in China.
The study identified several AMR genes in Proteus mirabilis isolates from foxes, raccoons, and minks in China, including blaTEM, blaOXA-1, aac(6′)Ib-cr, floR, sul1, blaNDM, and blaOXA-24. These genes conferred resistance to various antibiotics, with a high prevalence of multidrug-resistant isolates.
Comparison of Reference-Based Assembly and De Novo Assembly for Bacterial Plasmid Reconstruction and AMR Gene Localization in Salmonella enterica Serovar Schwarzengrund Isolates.
The study identified various AMR genes in Salmonella enterica serovar Schwarzengrund isolates, including aadA2, AAC(3)-IV, AAC(6')-Iy, APH(4)-Ia, cmlA1, dfrA12, floR, sul1, sul2, sul3, TEM-1, and tet(A). These genes were located on both the chromosome and plasmids, highlighting the importance of plasmid-mediated AMR gene transmission.
River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics.
The study identified various antibiotic resistance genes (ARGs) in river biofilms upstream and downstream of a wastewater treatment plant (WWTP), including qnrA, qnrS, mfsA, ermC, ermX, macB, mefA_10, cat, catB3, aadB, aph(3')-III, AAC(3)-Ib, bacA_1, blaPer-1, blaIMP, blaTEM, blaKPC, blaDHA, cblA, ermC, ermY, ermX, mdtL, cusF, copD, qacA, mecA, dfrF, arnA, sul1, sulA, vat(A), IS6100, ISS1N, Intl1, blaCTX-M, blaIMP, mefA_10, tolC, mdfF, acrA, dfrA27, aac(6')-IIa, vanA, intl3, and TTV. These genes were associated with resistance to various antibiotics such as fluoroquinolones, macrolides, chloramphenicol, aminoglycosides, beta-lactams, polymyxins, sulfonamides, and others. The study also found that the resistome composition varied between upstream and downstream sites, indicating the impact of WWTP effluents on the distribution of ARGs in river biofilms.
First identification of bla (NDM-5) producing Escherichia coli from neonates and a HIV infected adult in Tanzania.
The study identifies bla NDM-5 producing Escherichia coli in Tanzania, highlighting the presence of carbapenem resistance and other resistance genes on various plasmids.
Pan-Genome Analysis of Delftia tsuruhatensis Reveals Important Traits Concerning the Genetic Diversity, Pathogenicity, and Biotechnological Properties of the Species.
The study identifies multiple antimicrobial resistance genes in Delftia tsuruhatensis, including aminoglycoside, sulfonamide, trimethoprim, tetracycline, and phenicol resistance genes, indicating the potential for multidrug resistance in this species.
Yersinia pestis antibiotic resistance: a systematic review.
Genomic characterization of multidrug-resistant Salmonella serovar Kentucky ST198 isolated in poultry flocks in Spain (2011-2017).
The study identified multiple antimicrobial resistance genes in multidrug-resistant Salmonella serovar Kentucky ST198 isolates from Spain, including genes conferring resistance to aminoglycosides, beta-lactams, sulfonamides, tetracyclines, trimethoprim, and colistin.
Genetic and virulence characteristics of a Raoultella planticola isolate resistant to carbapenem and tigecycline.
The study identifies multiple antibiotic resistance genes in a Raoultella planticola isolate, including bla KPC-2, bla NDM-1, and tmexCD1-toprJ1, which confer resistance to carbapenems, cephalosporins, and tigecycline, respectively.
Genetic Diversity of Antimicrobial Resistance and Key Virulence Features in Two Extensively Drug-Resistant Acinetobacter baumannii Isolates.
The study identified various AMR genes in two extensively drug-resistant A. baumannii isolates, including aminoglycoside resistance genes, sulfonamide resistance genes, beta-lactamase genes, and efflux pump genes, highlighting the complexity of their resistance mechanisms.
Genetic Characterization of Antibiotic Resistant Enterobacteriaceae Isolates From Bovine Animals and the Environment in Nigeria.
The study characterizes antibiotic resistance genes in Enterobacteriaceae isolates from bovine animals and the environment in Nigeria, identifying several beta-lactamase, aminoglycoside modifying enzymes, qnr, sulfonamide, tetracycline, and trimethoprim resistance genes, highlighting the presence of multidrug-resistant strains.
Classification of 27 Corynebacterium kroppenstedtii-Like Isolates Associated with Mastitis in China and Descriptions of C. parakroppenstedtii sp. nov. and C. pseudokroppenstedtii sp. nov.
The study identifies two new species, Corynebacterium parakroppenstedtii and Corynebacterium pseudokroppenstedtii, and characterizes antibiotic resistance genes including APH(3')-Ia, APH(3'')-Ib, APH(6)-Id, erm(X), sul1, and tet(W) in C. kroppenstedtii-like isolates.
Frequently used therapeutic antimicrobials and their resistance patterns on Staphylococcus aureus and Escherichia coli in mastitis affected lactating cows.
The study identified several antimicrobial resistance genes in Staphylococcus aureus and Escherichia coli isolated from mastitis-affected cows, including mecA, tetK, tetL, tetA, tetB, sul1, and sul2. These genes confer resistance to various antibiotics such as tetracycline, sulfamethoxazole-trimethoprim, and methicillin.
Healthcare-associated infections caused by chlorhexidine-tolerant Serratia marcescens carrying a promiscuous IncHI2 multi-drug resistance plasmid in a veterinary hospital.
The study identifies multiple antimicrobial resistance genes in Serratia spp. isolates from hospitalized animals, highlighting the presence of a promiscuous IncHI2 plasmid carrying resistance genes against several high-importance antimicrobials.
Virulome and genome analyses identify associations between antimicrobial resistance genes and virulence factors in highly drug-resistant Escherichia coli isolated from veal calves.
The study identifies multiple antimicrobial resistance genes (ARGs) in highly drug-resistant Escherichia coli isolates from veal calves, including blaCMY-2, blaCTX-M-15, mph(A), erm(B), aac(6')-Ib-cr, qnrS1, aadA5, aadA1, aph(3')-Ic, aph(3')-Ia, aph(3')-Ib, aph(6')-Id, sul1, sul2, tet(A), and tet(B). Additionally, mutations in gyrA (S83L, D87N) and parC (A56T) were found to contribute to fluoroquinolone resistance.
Virulence determinant and antimicrobial resistance traits of Emerging MDR Shiga toxigenic E. coli in diarrheic dogs.
The study identified several AMR genes in MDR Shiga toxigenic E. coli (STEC) isolated from diarrheic dogs in Egypt, including bla TEM, bla CTX-M, bla KPC, bla NDM-1, tet A, tet B, sul 1, and qnr A. These genes confer resistance to various antibiotics such as penicillins, cephalosporins, carbapenems, tetracyclines, sulfonamides, and quinolones.
Genomic diversity and antimicrobial resistance among non-typhoidal Salmonella associated with human disease in The Gambia.
The study identified various antimicrobial resistance (AMR) genes in non-typhoidal Salmonella isolates from The Gambia, including aac(6')-Iaa_1, aph_3_Ib, aph_6_Id, dfrA14, dfrA7, dfrA8, blaTEM-1B, catA1_1, fosA7_1, mph_A, sul1, sul2, tet_A, and tet_B. These genes confer resistance to aminoglycosides, trimethoprim, beta-lactams, chloramphenicol, fosfomycin, macrolides, sulfonamides, and tetracyclines. The study also found that multidrug resistance (MDR) was primarily associated with Salmonella serovar Enteritidis, especially in the eastern region.
Carbapenem-Resistant Acinetobacter baumannii in U.S. Hospitals: Diversification of Circulating Lineages and Antimicrobial Resistance.
The study identifies multiple carbapenemase genes, including blaOXA-23 and blaOXA-207, as well as various resistance islands harboring genes such as aacA4, catB8, and armA, contributing to the multidrug resistance of CR Ab isolates in U.S. hospitals.
Global population structure of the Serratia marcescens complex and identification of hospital-adapted lineages in the complex.
The study identified multiple antimicrobial resistance (AMR) genes and mutations in the Serratia marcescens complex, highlighting the presence of hospital-adapted lineages with a high prevalence of multidrug-resistant (MDR) strains. Key AMR genes include blaCTX-M, blaNDM, blaOXA, qnrS1, tet(A), aac(6')-Ib, mph(A), erm(B), aadA, floR, sul1, and dfrA12, which confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, tetracyclines, aminoglycosides, macrolides, florfenicol, sulfonamides, and trimethoprim.
Pathogenic E. coli from Cattle as a Reservoir of Resistance Genes to Various Groups of Antibiotics.
The study identified various AMR genes in pathogenic E. coli strains from cattle in Romania and France, highlighting the presence of multidrug-resistant (MDR) strains and the diversity of resistance mechanisms.
Invited Review: Antimicrobial Use and Antimicrobial Resistance in Pathogens Associated with Diarrhea and Pneumonia in Dairy Calves.
The review identified several AMR genes in pathogens associated with calf diarrhea and pneumonia, including beta-lactamases (blaCMY, blaCTX-M, blaTEM), tetracycline resistance genes (tetA, tetB, tetM, tetO), aminoglycoside resistance genes (strA, strB, aadA), sulfonamide resistance genes (sul1, sul2), phenicol resistance genes (cat, floR), and macrolide/lincosamide resistance genes (cfr, ermB).
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
Use of genomics to explore AMR persistence in an outdoor pig farm with low antimicrobial usage.
The study identified various AMR genes in E. coli isolates from a low antimicrobial usage pig farm, highlighting the persistence of multidrug-resistant strains despite minimal selective pressure.
Antimicrobial resistance determinants in silage.
The study identified 16 antimicrobial resistance genes (ARGs) in silage samples, highlighting their potential to spread through the food chain and contribute to antimicrobial resistance.
Nitrogen Regulates the Distribution of Antibiotic Resistance Genes in the Soil-Vegetable System.
The study identified that nitrogen application affects the abundance of antibiotic resistance genes (ARGs) such as blaTEM-1, sul1, and tnpA-4 in the soil-vegetable system, but does not alter their distribution patterns within the vegetable. The findings highlight the importance of nitrogen management in controlling ARG transfer and accumulation in crops.
Genetic Diversity, Distribution, and Genomic Characterization of Antibiotic Resistance and Virulence of Clinical Pseudomonas aeruginosa Strains in Kenya.
The study identified multiple AMR genes and mutations in P. aeruginosa isolates from Kenya, including carbapenemases (blaNDM-1, blaVIM-6), fluoroquinolone resistance genes (qnrVC1, crpP), aminoglycoside resistance genes (aac(3)-IId, aph(3')-Ib, ant(3'')-Ia), tetracycline resistance genes (tetA, tetG), phenicol resistance genes (floR, cmlA), sulfonamide resistance gene (sul), trimethoprim resistance gene (dfrB), glycopeptide resistance gene (ble), and macrolide resistance gene (EreA). Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
Emergence of extensively drug-resistant Aeromonas hydrophila complex isolated from wild Mugil cephalus (striped mullet) and Mediterranean seawater.
The study identified extensively drug-resistant (XDR) Aeromonas hydrophila complex from wild Mugil cephalus and Mediterranean seawater, carrying resistance genes blaTEM, sul1, and tetA(A), and the virulence gene act. None of the isolates carried the aadA1 gene despite phenotypic resistance to streptomycin.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2019-2020.
The report highlights the presence of various antimicrobial resistance genes such as blaVIM-1, blaTEM-1B, blaTEM-1C, and cfr in different bacterial isolates, indicating resistance to carbapenems, beta-lactams, and macrolides/lincosamides/streptogramin B.
Mechanism for Reducing the Horizontal Transfer Risk of the Airborne Antibiotic-Resistant Genes of Escherichia coli Species through Microwave or UV Irradiation.
The study identified that the sul1, sul2, and sul3 genes in E. coli CICC 10667 contribute to sulfanilamide resistance and are more resistant to microwave irradiation compared to other genes. The effectiveness of microwave irradiation in reducing the horizontal transfer risk of antibiotic-resistant genes was demonstrated.
The Current Landscape of Antibiotic Resistance of Salmonella Infantis in Italy: The Expansion of Extended-Spectrum Beta-Lactamase Producers on a Local Scale.
The study identified multiple antimicrobial resistance genes in Salmonella Infantis strains from Italy, including blaCTX-M-1, aadA1, dfrA1, dfrA14, sul1, and tet(A), which contribute to resistance against various antibiotics such as beta-lactams, aminoglycosides, trimethoprim, sulfonamides, and tetracyclines.
Analysis of Antimicrobial Resistance in Non-typhoidal Salmonella Collected From Pork Retail Outlets and Slaughterhouses in Vietnam Using Whole Genome Sequencing.
The study identified several AMR genes in non-typhoidal Salmonella isolates from pork retail outlets and slaughterhouses in Vietnam, including blaTEM-1, blaTEM-150, blaLAP-2, blaCTX-M-55, dfrA12, dfrA14, floR, cmlA1, tetA, tetB, tetM, mcr-1, mcr-3, qnrS1, mphA, aadA1, aadA2, aac(6')-laa, aac(6')-ly, sul1, sul2, sul3, aph(3")-lb, and aph6-ld. These genes conferred resistance to various antibiotics such as ampicillin, penicillins, first-generation cephalosporins, quinolones, trimethoprim, chloramphenicol, tetracycline, colistin, macrolides, gentamicin, sulfonamides, and others.
Metagenomic Insights Into the Changes of Antibiotic Resistance and Pathogenicity Factor Pools Upon Thermophilic Composting of Human Excreta.
The study identified a decrease in the abundance of various antibiotic resistance genes (ARGs) during thermophilic composting of human excreta, including genes conferring resistance to aminoglycosides, macrolides, sulfonamides, and tetracyclines.
Identifying the Sources of Intestinal Colonization With Extended-Spectrum β-Lactamase-Producing Escherichia coli in Healthy Infants in the Community.
The study identifies several AMR genes, including blaCTX-M-15, qnrS1, ermB, aadA1, aph(3')-Ib, aph(6)-Id, dfrA1, catA1, aadA2, dfrA5, dfrA12, qnrS13, aac(6')-Ib-cr5, blaTEM-1, blaOXA-1, sul1, and dfrA17, associated with ESBL-Ec in children, mothers, and drinking water in rural Bangladesh.
Carbendazim shapes microbiome and enhances resistome in the earthworm gut.
Carbendazim (CBD) increases the abundance and diversity of antibiotic resistance genes (ARGs) in the earthworm gut, particularly multidrug, glycopeptide, tetracycline, and sulfonamide resistance genes.
In vitro Synergistic Activities of Fosfomycin in Combination with Other Antimicrobial Agents Against Carbapenem-Resistant Escherichia coli Harboring bla (NDM-1) on the IncN2 Plasmid and a Study of the Genomic Characteristics of These Pathogens.
The study identified several AMR genes in bla NDM-1 -harboring CREC isolates, including bla NDM-1, aac(3)-IId, aph(3")-Ib, aph(6)-Id, aadA5, aadA16, aac(6')-Ib-cr, qnrB6, ARR-3, dfrA17, dfrA27, sul1, sul2, tet(A), mph(A), bla TEM-1C, bla TEM-57, bla CTX-M-14, bla CTX-M-15, and bla CMY-2. These genes conferred resistance to various antibiotics, including carbapenems, aminoglycosides, fluoroquinolones, rifampicin, trimethoprim, sulfonamides, tetracycline, and macrolides.
Antimicrobial resistance and genetic background of non-typhoidal Salmonella enterica strains isolated from human infections in São Paulo, Brazil (2000-2019).
The study identifies several AMR genes, including blaTEM-1, dfrA1, tetA, sul1, floR, aac(6')-laa, qnrE1, aadA1, and aac(6')-ly, in non-typhoidal Salmonella enterica strains. It also reports mutations in mgrB, pmrB, and pmrC associated with colistin resistance.
Antimicrobial Resistance in Escherichia coli from the Broiler Farm Environment, with Detection of SHV-12-Producing Isolates.
The study identifies SHV-12-producing Escherichia coli isolates in a broiler farm environment, highlighting the presence of various antimicrobial resistance genes such as bla SHV-12, cmlA, tet (A), aac(6′)-Ib-cr, and others. These genes confer resistance to multiple antibiotics, emphasizing the need for monitoring and controlling AMR in agricultural settings.
Urban Wildlife Crisis: Australian Silver Gull Is a Bystander Host to Widespread Clinical Antibiotic Resistance.
The study identifies multiple antibiotic resistance genes, including bla_IMP-4, bla_SHV-12, sul1, sul2, mphA, and floR, in Escherichia coli isolates from Australian silver gulls, highlighting the role of wildlife in the spread of clinical antibiotic resistance.
Multidrug Resistance Genes Carried by a Novel Transposon Tn7376 and a Genomic Island Named MMGI-4 in a Pathogenic Morganella morganii Isolate.
The study identifies a novel transposon Tn7376 and a genomic island MMGI-4 in a multidrug-resistant Morganella morganii isolate, carrying multiple antimicrobial resistance genes including dfrA24, mph(A), aadA1, sul1, floR, catA2, cmlA1, aph(3')-Ia, aac(6')-Ib-cr, tet(A), tet(B), arr-3, blaTEM-1B, blaDHA-17, blaCARB-2, blaOXA-1, blaCTX-M-3, and fosA3.
Molecular diagnostics and next-generation sequencing reveal real etiological characteristics of invasive Salmonella infection in febrile illness in Freetown, Sierra Leone.
The study identified several antimicrobial resistance genes in a Salmonella Typhi isolate, including aac(6')-Iaa, catA1, dfrA15, and sul1, indicating resistance to aminoglycosides, phenicols, trimethoprim, and sulfonamides.
Hybrid Plasmids Encoding Antimicrobial Resistance and Virulence Traits Among Hypervirulent Klebsiella pneumoniae ST2096 in India.
The study characterizes hybrid plasmids in MDR-HvKp ST2096 isolates from India, identifying multiple AMR genes such as bla NDM-5, bla OXA-232, aadA2, armA, and others, along with virulence genes like rmpA2 and iucABCD.
Submarine Outfalls of Treated Wastewater Effluents are Sources of Extensively- and Multidrug-Resistant KPC- and OXA-48-Producing Enterobacteriaceae in Coastal Marine Environment.
The study identified extensively drug-resistant (XDR) and multidrug-resistant (MDR) KPC- and OXA-48-producing Enterobacteriaceae in coastal marine environments, highlighting the presence of various AMR genes including bla KPC-2, bla OXA-48, and others.
Genomic epidemiology and temperature dependency of hypermucoviscous Klebsiella pneumoniae in Japan.
The study identifies multiple AMR genes and mutations in hypermucoviscous Klebsiella pneumoniae isolates from Japan, highlighting the presence of ESBLs, carbapenemases, and other resistance determinants. It also reveals temperature-dependent variations in the HMV phenotype and the genetic diversity of the isolates.
KPC-3-, GES-5-, and VIM-1-Producing Enterobacterales Isolated from Urban Ponds.
The study identified bla KPC-3, bla GES-5, and bla VIM genes in various Enterobacterales isolates from urban ponds, highlighting their role in carbapenem resistance.
Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen.
The study identifies multiple AMR genes and mutations in Klebsiella pneumoniae isolates, including bla CTX-M-15, bla IMP-4, bla OXA-48, qnrB1, qnrS1, aac(6')-Ib-cr, rmtB, aac(6')-Ib4, aadA2, ant(2")-Ia, ermB, arr-2, dfrA14, sul2, and sul1, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, aminoglycosides, and sulfonamides.
RETRACTED: Isolation and molecular characterization of extended spectrum beta lactamase producing Escherichia coli from chicken meat in Pakistan.
The study identified several AMR genes including blaOXA-1, blaTEM-1, blaCTX-M15, QnrS, TetA, AAC, AAD, Sul1, and Sul2 in E. coli isolates from chicken meat in Pakistan. Mutations in blaOXA-1 (H81Q), blaTEM-1 (C108Y, T214A, K284E, P301S), QnrS (H95R), and Sul2 (E66A) were also detected.
Escherichia coli ST1193: Following in the Footsteps of E. coli ST131
The paper characterizes Escherichia coli ST1193 as an emerging multidrug-resistant clone with various AMR determinants, including beta-lactamases (bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-55, bla OXA-1, bla TEM-1, bla CMY-42, bla CMY-2), aminoglycoside-modifying enzymes (aac(3)-IIa, aac(3)-IId, aac(6′)-Ib-cr, aadA1, aadA2, aadA5, aph(3′′)-Ib, aph(6)-Id), and other resistance genes (mcr-1, mph(A), erm(B), dfrA8, dfrA12, dfrA17, sul1, sul2, tetA, tetB).
Genomic Characterization of an O101:H9-ST167 NDM-5-Producing Escherichia coli Strain from a Kitten in Italy.
The study characterizes an NDM-5-producing Escherichia coli ST167 strain from a kitten in Italy, highlighting the presence of multiple AMR genes including blaNDM-5, bla_ble, blaAmpH, blaAmpC1, and others, along with mutations in gyrA, parC, and parE contributing to fluoroquinolone resistance.
Epidemiological and genetic characteristics of clinical carbapenem-resistant Acinetobacter baumannii strains collected countrywide from hospital intensive care units (ICUs) in China.
The study identified multiple AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii (CRAB) strains, highlighting the prevalence of bla OXA-23 and bla OXA-66 as key determinants of carbapenem resistance, along with other resistance mechanisms such as mutations in efflux pump genes and modifications in lipopolysaccharide synthesis.
GR13-type plasmids in Acinetobacter potentiate the accumulation and horizontal transfer of diverse accessory genes.
The study identifies multiple antibiotic resistance genes, including bla OXA-58, bla NDM-1, ble MBL, sul2, aacC2d, msr(E)-mph(E), and tet(B), in GR13-type plasmids from Acinetobacter isolates, highlighting their role in multidrug resistance and horizontal gene transfer.
Cross-Sectional Survey of Antibiotic Resistance in Extended Spectrum β-Lactamase-Producing Enterobacteriaceae Isolated from Pigs in Greece.
The study identified a high prevalence of ESBL-producing Enterobacteriaceae in Greek pigs, with a focus on resistance mechanisms involving bla CTX-M1/15, bla TEM, and bla SHV genes, as well as resistance to fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and colistin.
Occurrence of bla(NDM-1)-Positive Providencia spp. in a Pig Farm of China.
Four bla NDM-1-positive Providencia strains were identified in a pig farm in China, showing multidrug resistance and carrying additional resistance genes such as bla OXA-10, bla TEM-116, and others.
mcr-1-Mediated Colistin Resistance and Genomic Characterization of Antimicrobial Resistance in ESBL-Producing Salmonella Infantis Strains from a Broiler Meat Production Chain in Italy.
The study identified mcr-1.1 and mcr-1.2 variants on IncX4 plasmids in colistin-resistant Salmonella Infantis strains, along with other resistance genes such as blaCTX-M-1, aac(6')-Iaa, tet(A), dfrA1, sul1, and qacE.
Characterization of β-Lactamases and Multidrug Resistance Mechanisms in Enterobacterales from Hospital Effluents and Wastewater Treatment Plant.
The study identified several β-lactamase genes, including bla CTX-M-27, bla TEM-1, bla CTX-M-15, bla CTX-M-30, and bla SHV-12, along with a variety of other AMR genes such as aadA5, aph(3''-Ib), aph(6)-Id, aac(3)-IIa, sul1, sul2, dfrA17, dfrA14, qnrB1, tet(A), mph(A), qacE∆, and catB3, which confer resistance to various antibiotics in Enterobacterales isolated from hospital effluents and wastewater treatment plants.
Genomic Analysis of Two MDR Isolates of Salmonella enterica Serovar Infantis from a Spanish Hospital Bearing the bla(CTX-M-65) Gene with or without fosA3 in pESI-like Plasmids.
The study reports two multidrug-resistant (MDR) isolates of Salmonella enterica serovar Infantis from Spain carrying the blaCTX-M-65 gene on pESI-like plasmids, along with other resistance genes such as floR, aac(3)-IVa, aph(3′)-Ia, aph(4)-Ia, aadA1, tet(A), sul1, dfrA14, and fosA3. Mutations in gyrA and parC were associated with fluoroquinolone resistance, while truncations in nsfA and nsfB were linked to nitrofurantoin resistance.
Prevalence and Molecular Characterisation of Extended-Spectrum Beta-Lactamase-Producing Shiga Toxin-Producing Escherichia coli, from Cattle Farm to Aquatic Environments.
The study identified several AMR genes, including sul1, sul2, bla OXA, bla CTX-M, bla TEM, and qnrS, in ESBL-producing STEC isolates from cattle farms and aquatic environments.
Antimicrobial susceptibility and genomic profiling of Salmonella enterica from bloodstream infections at a tertiary referral hospital in Lusaka, Zambia, 2018-2019.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella enterica isolates, including blaTEM-1B, catA1, sul2, sul1, dfrA7, dfrA14, and mutations in gyrA, gyrB, and parC. These resistance mechanisms contribute to multidrug resistance and emerging resistance to ciprofloxacin and cephalosporins.
Genomic Analysis of a Highly Virulent NDM-1-Producing Escherichia coli ST162 Infecting a Pygmy Sperm Whale (Kogia breviceps) in South America.
The study identifies a multidrug-resistant NDM-1-producing E. coli ST162 strain isolated from a pygmy sperm whale, highlighting the presence of various AMR genes including blaNDM-1, blaTEM-1C, blaOXA-1, and others, as well as mutations in gyrA and parC contributing to fluoroquinolone resistance.
Genome analysis and virulence gene expression profile of a multi drug resistant Salmonella enterica serovar Typhimurium ms202.
The study identified multiple antimicrobial resistance genes in the multi-drug resistant Salmonella enterica serovar Typhimurium ms202 strain, including fosA7, sul1, aadA7, aac(6')-laa, tet(A), and qacE, which confer resistance to various antibiotics such as fosfomycin, sulfamethoxazole, spectinomycin, amikacin, tetracycline, and disinfectants.
Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches.
The study identifies several AMR genes and mutations associated with resistance to various antibiotics in wastewater environments, highlighting the role of these genes in the spread of antimicrobial resistance.
Genetic Analysis of Carbapenem-Resistant Acinetobacter baumannii Isolates from India: Identification of Resistance Islands and Mobile Genetic Elements
This study identified various AMR genes including blaOXA-23, blaNDM-1, aph(3')-Ib, aph(6)-Id, armA, mph, msr, cmlA1, ARR-2, sul1, sul2, tet(B), and blaPER-7 in carbapenem-resistant Acinetobacter baumannii isolates from India. These genes were found to be associated with resistance islands and mobile genetic elements, contributing to the spread of multidrug resistance.
Assessment of multidrug-resistant Listeria monocytogenes in milk and milk product and One Health perspective.
The study identified multiple antimicrobial resistance genes in Listeria monocytogenes isolates from milk and milk products, including beta-lactamase genes (bla TEM, bla SHV, bla Z), tetracycline resistance genes (tet A, tet D, tet G, tet K, tet M), sulfonamide resistance genes (sul 1, sul 2), and an aminoglycoside resistance gene (aph (3)-IIa (aphA2)).
Genomic and Evolutionary Analysis of Salmonella enterica Serovar Kentucky Sequence Type 198 Isolated From Livestock In East Africa.
The study identified multiple antimicrobial resistance genes in Salmonella enterica serovar Kentucky ST198 isolates from East Africa, including aac(3)-Id, aadA7, strA, strB, bla TEM-1B, sul1, and tet(A), which confer resistance to aminoglycosides, streptomycin, ampicillin, sulfamethoxazole, and tetracycline. Mutations in gyrA and parC were associated with ciprofloxacin resistance.
Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates.
The study identified various antimicrobial resistance genes and mutations in Klebsiella pneumoniae bloodstream isolates, highlighting the presence of multidrug-resistant and hypervirulent strains in the United States.
First Report of bla (CTX-M-167), bla (SHV-1), and bla (TEM-1B) Carrying Klebsiella pneumonia Showing High-Level Resistance to Carbapenems.
The study identifies the first report of a carbapenem-resistant Klebsiella pneumoniae strain carrying bla CTX-M-167, bla TEM-1B, and bla SHV-1, along with other resistance genes such as qnrS1, aac(6')-1b-cr, aadA16, tet(A), fosA, sul1, and mph(A).
Genomic Investigation of Proteus mirabilis Isolates Recovered From Pig Farms in Zhejiang Province, China.
The study identified 91 antimicrobial resistance genes in 30 Proteus mirabilis isolates from pig farms in Zhejiang, China, including genes encoding resistance to various antibiotics such as beta-lactams, aminoglycosides, sulfonamides, and fluoroquinolones.
A tale of two plasmids: contributions of plasmid associated phenotypes to epidemiological success among Shigella.
The study identifies that the plasmid pKSR100 confers a broader range of antimicrobial resistance compared to pAPR100, contributing to its greater epidemiological success. pKSR100 carries more AMR genes, including those for macrolides, sulfonamides, trimethoprim, beta-lactams, aminoglycosides, and tetracyclines, while pAPR100 has fewer AMR genes, primarily for macrolides, beta-lactams, and tetracyclines.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Serotype Diversity and Antimicrobial Resistance Profile of Salmonella enterica Isolates From Freshwater Turtles Sold for Human Consumption in Wet Markets in Hong Kong.
The study identifies the multidrug-resistance gene cfr for the first time in Salmonella, highlighting the expansion of the cfr reservoir and potential horizontal spread to other bacteria. It also detects various AMR genes such as floR, sul2, aph(3')-Ia, aph(3”)-Ib, aph(6)-Id, aac(6')-Ib-cr, bla CMY−2, bla TEM−1, qnrS1, erm(B), mph(E), msr(E), qepA8, arr-3, sul1, dfrA12, dfrA27, tet(A), tet(D), catB3, aadA16, aac(3)-IV, aph(4)-Ia, aadA2, and fosA7.
Within-farm dynamics of ESBL-producing Escherichia coli in dairy cattle: Resistance profiles and molecular characterization by long-read whole-genome sequencing.
The study identified multiple ESBL-encoding genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, and bla SHV-12, as well as carbapenemase gene bla NDM-1, in ESBL-producing E. coli isolates from dairy cattle farms. These genes were associated with resistance to various beta-lactam antibiotics. Additionally, several other AMR genes such as aadA2, ant(3")-Ia, aph(3')-Ia, dfrA12, sul3, cmlA1, and others were identified, contributing to resistance against aminoglycosides, trimethoprim, sulfamethoxazole, and chloramphenicol. Mutations in gyrA, parC, and parE were linked to fluoroquinolone resistance.
Molecular characterisation of Acinetobacter baumannii isolates from bloodstream infections in a tertiary-level hospital in South Africa.
The study identified colistin-resistant Acinetobacter baumannii isolates with resistance genes including bla OXA-23, bla NDM-1, lps B, and various efflux pumps. These isolates exhibited extensive drug resistance (XDR) and were associated with sequence types ST1 and ST2.
Emergence of a Novel NDM-5-Producing Sequence Type 4523 Klebsiella pneumoniae Strain Causing Bloodstream Infection in China.
The study identifies a novel sequence type 4523 Klebsiella pneumoniae strain, ST4523, which is resistant to multiple antibiotics, including carbapenems, and carries the bla NDM-5 gene on a plasmid. The strain also possesses various other resistance genes on plasmids pSHX180-1 and pSHX180-NDM5.
Genomic surveillance of Salmonella spp. in the Philippines during 2013-2014.
The study characterized various AMR genes and mutations in Salmonella isolates from the Philippines, highlighting the presence of ESBL genes, plasmid-mediated quinolone resistance genes, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
Dynamics of Genotypic and Phenotypic Antibiotic Resistance in a Conventional Wastewater Treatment Plant in 2 Years.
The study identified several AMR genes, including beta-lactamases (bla TEM, bla CTX-M-1, bla OXA-1), aminoglycoside resistance genes (strA, strB), sulfonamide resistance genes (sul1, sul2), and tetracycline resistance gene (tetA), in multidrug-resistant bacteria within a wastewater treatment plant over two years.
Prevalence and distribution of extended-spectrum β-lactamase and AmpC-producing Escherichia coli in two New Zealand dairy farm environments.
The study identified bla CMY-2, bla CTX-M-1, bla CTX-M-15, and bla OXA-1 genes in ESBL- and AmpC-producing E. coli isolates from New Zealand dairy farms, highlighting the presence of plasmid-mediated resistance mechanisms.
World Health Organization critical priority Escherichia coli clone ST648 in magnificent frigatebird (Fregata magnificens) of an uninhabited insular environment.
The study identified a multidrug-resistant ST648 E. coli isolate carrying various AMR genes, including blaCTX-M-2, blaCMY-2, qnrB, tetB, sul1, sul2, aadA1, aac(3)-VIa, and mdfA, highlighting the presence of critical priority pathogens in wild birds.
Spatiotemporal Investigation of Antibiotic Resistance in the Urban Water Cycle Influenced by Environmental and Anthropogenic Activity.
The study identified several AMR genes, including carbapenemases (cphA5, cphA7, imiH, ESP-1), colistin resistance gene mcr-7.1, aminoglycoside resistance genes (aadA, aph(6)-Id, aph(3')-Ib), sulfonamide/trimethoprim resistance genes (sul1, dfrA15, dfrA14), and multidrug efflux pumps (MexB, OpmH, MexK) in various bacterial isolates from urban water samples.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Antidepressants promote the spread of antibiotic resistance via horizontally conjugative gene transfer.
The study shows that antidepressants can promote the conjugative transfer of antibiotic resistance genes (ARGs) between different bacterial genera, highlighting the potential link between antidepressant use and the spread of antibiotic resistance.
Urban rats as carriers of invasive Salmonella Typhimurium sequence type 313, Kisangani, Democratic Republic of Congo.
The study identified multidrug-resistant Salmonella Typhimurium ST313 in urban rats in Kisangani, Democratic Republic of Congo, highlighting their potential role as reservoirs of invasive Salmonella. The resistant isolates carried genes such as blaTEM-1, strA, strB, ant(3')-Ia, aac(3')-IId, sul1, sul2, dfrA1, tetB, and catA10, conferring resistance to multiple antibiotics.
Molecular epidemiology and carbapenem resistance characteristics of Acinetobacter baumannii causing bloodstream infection from 2009 to 2018 in northwest China.
The study identified multiple carbapenem resistance genes, including blaOXA-23 and blaOXA-72, along with other resistance mechanisms such as 16S rRNA methylase armA and aminoglycoside-modifying enzymes. The AdeABC efflux pump was also found to contribute to carbapenem resistance.
Genomic characteristics of clinical multidrug-resistant Proteus isolates from a tertiary care hospital in southwest China.
The study identifies multiple AMR genes in clinical multidrug-resistant Proteus isolates, including bla CTX-M-65, bla OXA-1, bla KPC-2, bla NDM-1, and others, highlighting the genetic diversity of mobile genetic elements carrying resistance genes.
Occurrence of Shiga toxin-producing Escherichia coli carrying antimicrobial resistance genes in sheep on smallholdings in Bangladesh.
The study identified the presence of antimicrobial resistance genes bla TEM, sul1, and sul2 in Shiga toxin-producing Escherichia coli (STEC) isolates from sheep in Bangladesh.
Molecular Typing Reveals Environmental Dispersion of Antibiotic-Resistant Enterococci under Anthropogenic Pressure.
The study identified multiple antibiotic resistance genes in Enterococcus isolates from various aquatic environments, highlighting the role of anthropogenic pressure in the spread of antibiotic-resistant enterococci.
Identification of a Novel IncHI1B Plasmid in MDR Klebsiella pneumoniae 200 from Swine in China.
The study identifies a novel IncHI1B plasmid, pYhe2001, in MDR Klebsiella pneumoniae 200 from swine, along with several resistance genes including blaCTX-M-27, aadA16, dfrA27, arr-6, aac(6')-Ib-cr, sul1, qnrB2, tetA, and floR. These genes contribute to resistance against multiple antibiotics.
Occurrence of Antimicrobial-Resistant Escherichia coli in Marine Mammals of the North and Baltic Seas: Sentinels for Human Health.
The study identified antimicrobial-resistant Escherichia coli in marine mammals from the North and Baltic Seas, highlighting the presence of resistance genes such as blaTEM, strA, strB, aadA1, sul1, sul2, tet(A), tet(B), tet(D), qnrS, floR, catA1, blaOXA-1-like, blaSHV, and blaCMY-2.
Epidemiology, Mechanisms of Resistance and Treatment Algorithm for Infections Due to Carbapenem-Resistant Gram-Negative Bacteria: An Expert Panel Opinion.
The paper discusses the mechanisms of resistance in carbapenem-resistant Gram-negative bacteria, highlighting the role of various beta-lactamases such as blaOXA-51, blaOXA-23, blaOXA-24, blaOXA-48, blaKPC, blaNDM, blaVIM, and blaIMP, as well as aminoglycoside modifying enzymes like aac(6')-Ib and aadA, and quinolone resistance genes such as qnrS1.
Comparative Genomic Analysis of Antimicrobial-Resistant Escherichia coli from South American Camelids in Central Germany.
The study identified various antimicrobial resistance genes in Escherichia coli isolates from South American camelids in Germany, highlighting the presence of multidrug-resistant strains and the importance of monitoring AMR in these animals.
Phage-Plasmids Spread Antibiotic Resistance Genes through Infection and Lysogenic Conversion.
Phage-plasmids (P-Ps) carry a variety of antibiotic resistance genes (ARGs), including beta-lactamases, aminoglycoside-modifying enzymes, and carbapenemases. These genes are often located in integrons and are associated with transposable elements. P-Ps can be induced by mitomycin C and can transfer resistance genes through lysogenic conversion.
Emergence of Extensively Drug-Resistant ST170 Citrobacter portucalensis with Plasmids pK218-KPC, pK218-NDM, and pK218-SHV from a Tertiary Hospital, China.
The study identifies the emergence of an extensively drug-resistant Citrobacter portucalensis strain, K218, which carries multiple resistance genes including bla KPC-2 and bla NDM-1, contributing to its multidrug-resistant phenotype.
Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Strains Recovered from Chilean Hospitals Reveals Lineages Specific to South America and Multiple Routes for Acquisition of Antibiotic Resistance Genes.
The study identifies various AMR genes in carbapenem-resistant Acinetobacter baumannii strains from Chile, including blaTEM, aacC2, aphA6, sul1, sul2, catA1, tetA(A), aadA1, dfrA1, strAB, cmlB1, floR, oxa58, and oxa23, highlighting the diversity of resistance mechanisms and the role of mobile genetic elements in their dissemination.
Antimicrobial resistance of Salmonella Indiana from retail chickens in China and emergence of an mcr-1-harboring isolate with concurrent resistance to ciprofloxacin, cefotaxime, and colistin.
The study identified multiple AMR genes in Salmonella Indiana isolates, including bla CTX-M-65, bla CTX-M-14, bla CTX-M-27, bla CTX-M-28, bla CTX-M-79, aac(6')-Ib-cr, oqxAB, and mcr-1, which contribute to resistance against various antibiotics.
Resistance and virulence features of hypermucoviscous Klebsiella pneumoniae from bloodstream infections: Results of a nationwide Italian surveillance study.
The study identified various AMR genes in hypermucoviscous Klebsiella pneumoniae isolates, including bla KPC-3, bla KPC-2, CMY-16, CTX-M-15, bla SHV-2, bla DHA-1, bla CTX-M-65, qnr, aadA1, aac(6')-Ib, sul1, dfrA1, mph(A), erm(B), floR, and fosA3. These genes conferred resistance to multiple antibiotics, including carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and fosfomycin.
Acquisition of genomic elements were pivotal for the success of Escherichia coli ST410
The study identified several AMR genes and mutations in Escherichia coli ST410, including bla OXA-181, bla NDM-5, bla CTX-M-15, and mutations in gyrA, parC, and parE that confer resistance to carbapenems, cephalosporins, penicillins, aminoglycosides, sulfonamides, trimethoprim, and fluoroquinolones.
Genome-wide analysis reveals the emergence of multidrug resistant Stenotrophomonas acidaminiphila strain SINDOREI isolated from a patient with sepsis.
The study identifies multiple antibiotic resistance genes in the multidrug-resistant Stenotrophomonas acidaminiphila strain SINDOREI, including sul1, sul2, qnr, GES-1, aadA3, qacL, cmlA5, and tetC, which confer resistance to trimethoprim/sulfamethoxazole, fluoroquinolone, beta-lactam, aminoglycoside, disinfecting agents, phenicol, and tetracycline.
Antibiotic-Resistant Bacteria and Resistance Genes in Isolates from Ghanaian Drinking Water Sources.
The study identified antibiotic-resistant bacteria carrying resistance genes such as bla_NDM-1, sul1, tet(O), and tet(W) in Ghanaian drinking water sources, highlighting the presence of multidrug-resistant isolates and the potential public health risks associated with contaminated water.
Antimicrobial susceptibility to polymyxin B and other comparators against Gram-negative bacteria isolated from bloodstream infections in China: Results from CARVIS-NET program.
The study found that 94.1% of the 1939 Gram-negative isolates were susceptible to polymyxin B, and the sensitivity of the strains to polymyxin B was highly correlated with their sensitivity to colistin.
Prevalence, antibiotic profile, virulence determinants, ESBLs, and non-β-lactam encoding genes of MDR Proteus spp. isolated from infected dogs.
The study identified multiple AMR genes in MDR Proteus spp. isolated from dogs, including bla TEM, bla SHV, bla CTX-M, bla OXA-1, sul1, tetA, aadA1, qnrA, intI1, ure C, zap A, and rsb A. These genes conferred resistance to various antibiotics such as penicillins, cephalosporins, sulfonamides, tetracyclines, quinolones, and aminoglycosides.
Dominance of phage particles carrying antibiotic resistance genes in the viromes of retail food sources.
The study identifies and characterizes the presence of antibiotic resistance genes (ARGs) in phage particles from retail food sources, demonstrating that these phages can carry and potentially transfer resistance genes such as bla TEM, sul1, and tetW.
Antimicrobial Resistance Pattern, Clustering Mechanisms and Correlation Matrix of Drug-Resistant Escherichia coli in Black Bengal Goats in West Bengal, India.
The study identified several AMR genes in multidrug-resistant E. coli isolates from goats, including bla CTXM-1, bla AmpC, bla SHV, bla TEM, bla CMY-6, bla CITM, bla NDM-5, qnr B, qnr S, aac(6')-Ib-cr, tet A, tet B, sul 1, and the acrAB efflux pump system.
Three Distinct Annotation Platforms Differ in Detection of Antimicrobial Resistance Genes in Long-Read, Short-Read, and Hybrid Sequences Derived from Total Genomic DNA or from Purified Plasmid DNA.
The study compared different annotation platforms for detecting antimicrobial resistance (AMR) genes in various sequencing data types. It found that plasmid DNA purification was unnecessary for detecting plasmid-borne AMR genes and that hybrid sequencing improved AMR gene detection. The study also highlighted variations in AMR gene detection among different databases.
Epidemiological links and antimicrobial resistance of clinical Salmonella enterica ST198 isolates: a nationwide microbial population genomic study in Switzerland.
The study identifies several AMR genes and mutations associated with ciprofloxacin resistance in Salmonella enterica ST198 isolates, including aac(3)-Id, aadA7, bla TEM-1b, sul1, tetA, qnrB1, qnrS1, bla CTX-M-14b, bla VEB-8, and bla OXA-48. Additionally, inactivating mutations in ramR and acrB were found to contribute to high-level ciprofloxacin resistance.
The first outbreak of citrobacteriosis caused by Citrobacter gillenii in reared Russian sturgeon (Acipenser gueldenstaedtii) in Turkiye.
Citrobacter gillenii was identified as the causative agent of a fatal bacterial disease in Russian sturgeon. Resistance genes ampC, sul1, and floR were detected, conferring resistance to penicillin, trimethoprim/sulfamethoxazole, and florfenicol, respectively.
Genomic Analysis and Molecular Characteristics in Carbapenem-Resistant Klebsiella pneumoniae Strains.
The study identified several AMR genes, including bla KPC-2, bla SHV-11, bla TEM-1, CTX-M, qnrS, oqxB1, sul1, sul2, int1, iutA, and rmpA2, in carbapenem-resistant Klebsiella pneumoniae strains.
Multistate reptile- and amphibian-associated salmonellosis outbreaks in humans, United States, 2009-2018.
The study identified various AMR genes and mutations in Salmonella isolates from multistate reptile- and amphibian-associated salmonellosis outbreaks in the United States, including bla CMY-2, qnrB19, qnrS1, bla TEM-116, bla TEM-1C, bla TEM-1B, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, sul1, sul3, floR, tet(A), and sul2, which conferred resistance to multiple antibiotics such as ciprofloxacin, ceftriaxone, ampicillin, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline.
Genomic Characterization of an Extensively Drug-Resistant Extra-Intestinal Pathogenic (ExPEC) Escherichia coli Clinical Isolate Co-Producing Two Carbapenemases and a 16S rRNA Methylase.
The study describes an extensively drug-resistant (XDR) E. coli ST361 isolate co-carrying bla KPC-3, bla NDM-5, and various other resistance genes on multiple plasmids, showing resistance to nearly all antibiotics except tigecycline, colistin, and fosfomycin.
A First Report of Molecular Typing, Virulence Traits, and Phenotypic and Genotypic Resistance Patterns of Newly Emerging XDR and MDR Aeromonas veronii in Mugil seheli.
The study identified XDR and MDR Aeromonas veronii strains in Mugil seheli carrying resistance genes bla TEM, bla CTX-M, bla SHV, tet A, aad A1, and sul 1.
Conjugative transfer of multi-drug resistance IncN plasmids from environmental waterborne bacteria to Escherichia coli.
The study identified the transfer of multi-drug resistance IncN plasmids from environmental waterborne bacteria to E. coli, highlighting the presence of sulfonamide resistance genes sul1 and sul2 in transconjugants.
Antimicrobial resistance and genomic characterization of Salmonella enterica serovar Senftenberg isolates in production animals from the United States.
The study characterized antimicrobial resistance genes and mutations in Salmonella enterica serovar Senftenberg isolates from production animals in the United States, identifying genes such as aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, blaTEM-1B, blaCMY-2, blaSHV-12, floR, catA2, qnrB2, aac(6')-Ib-cr, aadA1, aadA2, sul1, sul2, tetA, and mcr-9.1, along with mutations in gyrA and parC genes contributing to resistance against various antibiotics.
Molecular Characterization and the Antimicrobial Resistance Profile of Salmonella spp. Isolated from Ready-to-Eat Foods in Ouagadougou, Burkina Faso.
The study identified several antimicrobial resistance genes in Salmonella isolates from ready-to-eat foods in Burkina Faso, including blaTEM, temB, sul1, sul2, aadA, tet(A), and tet(B). These genes confer resistance to various antibiotics such as ampicillin, cefoxitin, trimethoprim/sulfamethoxazole, and tetracycline.
Antimicrobial resistance: mechanisms and implications
The review discusses various molecular mechanisms of antibiotic resistance, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and efflux pumps, highlighting their roles in conferring resistance to multiple antibiotics.
Occurrence of virulence factors and carbapenemase genes in Salmonella enterica serovar Enteritidis isolated from chicken meat and egg samples in Iraq.
The study identified carbapenemase genes blaIMP, blaOXA-48-like, and blaNDM, along with tetracycline resistance genes tetA and tetB, and trimethoprim-sulfamethoxazole resistance genes dfrA1 and sul1 in Salmonella enterica serovar Enteritidis isolates from chicken meat and eggs in Iraq.
Establishing a marine monitoring programme to assess antibiotic resistance: A case study from the Gulf Cooperation Council (GCC) region.
The study identified several AMR genes in E. coli isolates from the GCC marine environment, including bla TEM-1, bla CTX-M-15, qnrS1, tet, sul, and dfr, which conferred resistance to various antibiotics such as ampicillin, cefotaxime, ceftazidime, ciprofloxacin, tetracycline, sulfamethoxazole, and trimethoprim.
The hazard of carbapenemase (OXA-181)-producing Escherichia coli spreading in pig and veal calf holdings in Italy in the genomics era: Risk of spill over and spill back between humans and animals.
The study identifies multiple AMR genes, including bla OXA-181, bla TEM-1B, aac (3)-IId, aad A2, cml A1, dfr A12, mef (B), sul 3, tet (A), tet (M), incX3, incX1, incFII, qnr S1, aph (3″)-Ib, aph (6)-Id, flo R, lnu (F), sul 2, sul 3, tet (B), mph (A), mph (G), qnr B4, rmt B, and fos A3, in OXA-181-producing E. coli isolates from pigs and bovines in Italy. These genes confer resistance to various antibiotics, including carbapenems, cephalosporins, penicillins, aminoglycosides, trimethoprim, macrolides, sulfonamides, tetracyclines, fluoroquinolones, and fosfomycin.
A sludge bulking wastewater treatment plant with an oxidation ditch-denitrification filter in a cold region: bacterial community composition and antibiotic resistance genes.
The study identified several antibiotic resistance genes (ARGs) in a sludge bulking wastewater treatment plant, including sul1, aadA5, ErmF, tet(A), and msrE, which confer resistance to sulfonamide, aminoglycoside, macrolide, tetracycline, and other antibiotics.
Molecular Characterization of Salmonella spp. Isolates from Wild Colombian Babilla (Caiman crocodilus fuscus) Isolated In Situ.
The study identified multiple antibiotic resistance genes in Salmonella isolates from wild Colombian babilla, including blaTEM, strB, sul1, blaCMY2, blaCTX-M, sul2, dfrA1, floR, and qnrD, indicating the potential of these reptiles as carriers of multidrug-resistant bacteria.
Aeromonas species isolated from aquatic organisms, insects, chicken, and humans in India show similar antimicrobial resistance profiles.
The study identified multiple antimicrobial resistance (AMR) genes in Aeromonas species isolated from various hosts in India, including beta-lactamases (bla OXA-12, bla OXA-427, bla OXA-724, bla OXA-780, bla FOX-2, bla FOX-4, bla FOX-5, bla FOX-7, bla AQU-2, bla MOX-7), metallo-beta-lactamases (cphA3, cphA4, cphA5, cphA8, ImiH), and other resistance genes (dfrA12, aadA2, ANT(3")-IIa, sul1). Additionally, multidrug efflux pump genes (mdtH, zntA, emrD, blR, crp) were found to contribute to AMR in these isolates.
The pan-genome of the emerging multidrug-resistant pathogen Corynebacterium striatum.
The study identifies 15 antimicrobial resistance genes in Corynebacterium striatum, including genes conferring resistance to aminoglycosides, tetracyclines, chloramphenicol, macrolides, lincosamides, streptogramins, sulfonamides, and cationic antiseptics. These genes are often located in genomic islands and mobile genetic elements, highlighting the role of horizontal gene transfer in the spread of multidrug resistance.
Rothia nasimurium as a Cause of Disease: First Isolation from Farmed Chickens.
Rothia nasimurium was isolated from chickens for the first time and found to exhibit multidrug resistance, carrying 13 resistance genes including bla TEM, bla CTX-M, mecA, sul1, sul2, sul3, aac(6′)-Ib, gyrA, aph(3′)-Ia, tet(A), tetM, and ermB.
In Vitro Assessment of Antimicrobial Activity of Phytobiotics Composition towards of Avian Pathogenic Escherichia coli (APEC) and Other E. coli Strains Isolated from Broiler Chickens.
The study identifies several AMR genes in E. coli strains, including aadA, strA/strB, aphA1, aphA2, tetA, tetB, sul1, sul2, sul3, dfrA1, dfrA10, dfrA12, floR, and blaSHV, which confer resistance to various antibiotics such as streptomycin, neomycin, tetracycline, sulfonamides, trimethoprim, chloramphenicol, and cephalosporins.
Genomic Analysis of Klebsiella pneumoniae ST258 Strain Coproducing KPC-2 and CTX-M-14 Isolated from Poultry in the Brazilian Amazon Region.
The study characterizes a multidrug-resistant Klebsiella pneumoniae ST258 strain (KP411) isolated from poultry in the Brazilian Amazon, which carries several AMR genes including blaKPC-2, blaCTX-M-14, and others, highlighting the potential of food-producing animals as reservoirs of MDR clones.
Intestinal colonization with ESBL-producing Klebsiella pneumoniae in healthy rural villager: A genomic surveillance study in China, 2015-2017.
The study identified multiple ESBL genes, including bla TEM-1B, bla CTX-M-14, and bla SHV-11, along with other resistance genes such as qnrS1, sul1, aac(6')-Ib-cr, aadA16, aph(3')-Ib, tet(A), and mcr-1, contributing to multidrug resistance in ESBL-producing Klebsiella pneumoniae isolates from healthy rural villagers in China.
Resistome and virulome diversity of foodborne pathogens isolated from artisanal food production chain of animal origin in the Mediterranean region.
The study identified various AMR genes in L. monocytogenes, Salmonella enterica, and S. aureus isolates from artisanal food production chains in the Mediterranean region, highlighting the presence of fosfomycin, aminoglycoside, beta-lactam, trimethoprim, sulfonamide, tetracycline, and streptomycin resistance mechanisms.
Molecular and Clinical Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Isolates at a Tertiary Hospital in Wuhan, China.
The study identified multiple carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates carrying various resistance genes, including blaKPC-1, blaCTX-M-65, blaTEM-1, blaSHV-182, rmtB, aadA2, APH(3')-Ia, sul1, sul2, QnrS1, mphA, FosA6, floR, and tet(A). These genes confer resistance to carbapenems, beta-lactams, aminoglycosides, sulfonamides, fluoroquinolones, macrolides, fosfomycin, chloramphenicol, and tetracyclines.
Hydrothermal pre-treatment followed by anaerobic digestion for the removal of tylosin and antibiotic resistance agents from poultry litter.
The study characterizes the removal of tylosin and antibiotic resistance genes (ARGs) from poultry litter using hydrothermal pre-treatment followed by anaerobic digestion. It identifies the reduction of ermB, intI1, sul1, and tetA genes, indicating effective mitigation of antibiotic resistance.
Comparative Genome Analysis of 19 Trueperella pyogenes Strains Originating from Different Animal Species Reveal a Genetically Diverse Open Pan-Genome.
The study identified 40 antibiotic resistance genes (ARGs) in 19 Trueperella pyogenes strains, including genes conferring resistance to aminoglycosides, tetracyclines, phenicols, sulfonamides, and macrolides.
Antimicrobial Resistance and Genetic Diversity of Pseudomonas aeruginosa Strains Isolated from Equine and Other Veterinary Samples.
The study identified several AMR genes in Pseudomonas aeruginosa strains isolated from equine and other veterinary samples, including beta-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes, sulfonamide resistance genes, phenicol resistance genes, tetracycline resistance genes, and efflux pumps. Additionally, genes conferring resistance to quaternary ammonium compounds were detected.
Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb.
The study identified several AMR genes in multidrug-resistant bacteria isolated from a COVID-19 hospital in Zagreb, including bla CTX-M-15 in E. coli and various bla OXA variants in A. baumannii. These genes conferred resistance to beta-lactams and aminoglycosides.
Conjugation of plasmid harboring bla (NDM-1) in a clinical Providencia rettgeri strain through the formation of a fusion plasmid.
The study identifies multiple AMR genes, including blaNDM-1, blaOXA-10, blaPER-4, aph(3')-VI, ant(2'')-Ia, ant(3')-Ia, sul1, catB8, catA1, mph(E), and tet, in a multidrug-resistant Providencia rettgeri strain. These genes contribute to resistance against various antibiotics, including carbapenems, beta-lactams, aminoglycosides, sulfonamides, chloramphenicol, macrolides, and tetracyclines.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Multidrug-resistant toxigenic Corynebacterium diphtheriae sublineage 453 with two novel resistance genomic islands.
Two multidrug-resistant toxigenic Corynebacterium diphtheriae isolates were analyzed, revealing two novel resistance genomic islands carrying 12 resistance genes, including ermX, cmx, aph(3')-Ib, aph(6)-Id, aadA1, dfrA15, sul1, cmlA, cmlR, and tet(33). Additionally, mutations in rpoB and gyrA were associated with resistance to rifampicin and ciprofloxacin, respectively.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Enhance antibiotic resistance and human health risks in aerosols during the COVID-19 pandemic.
The study identified increased abundances of antibiotic resistance genes (ARGs) in aerosols during the COVID-19 pandemic, particularly sulfonamide (sul1, sul2), tetracycline (tetA, tetC), and beta-lactam (ampC) resistance genes. These genes were associated with heightened antibiotic resistance in airborne bacteria, contributing to elevated human health risks.
Antibacterial efficacy of indigenous Pakistani honey against extensively drug-resistant clinical isolates of Salmonella enterica serovar Typhi: an alternative option to combat antimicrobial resistance.
The study identifies multiple AMR genes, including blaCTX-M-15, blaTEM-1, qnrS, qnrA, qnrB, Sul1, and pltB, in XDR S. Typhi isolates. Indigenous Pakistani honeys, particularly beri and neem honey, show potent antibacterial activity against these isolates.
Increasing trend of antimicrobial resistance in Shigella associated with MSM transmission in Barcelona, 2020-21: outbreak of XRD Shigella sonnei and dissemination of ESBL-producing Shigella flexneri.
The study reports an increasing trend of antimicrobial resistance in Shigella spp. among MSM in Barcelona, primarily due to the spread of XDR ESBL-producing S. sonnei and MDR ESBL-producing S. flexneri. Key AMR genes identified include bla CTX-M-27, mph(A), erm(B), dfrA17, sul1, and aadA5, along with fluoroquinolone resistance mutations in gyrA (S83L) and parC (S80I).
The fate of sulfonamide resistance genes and anthropogenic pollution marker intI1 after discharge of wastewater into a pristine river stream.
The study identifies and characterizes several sulfonamide resistance genes (sul1, sul2), the integrase gene intI1, and various other antibiotic resistance genes (ARGs) such as aadA2, aadA11, blaOXA-2, blaOXA-4, blaOXA-10, blaOXA-33, blaOXA-36, blaOXA-129, blaOXA-392, blaOXA-824, blaBEL-1, blaGES-11, ereA2, cmlA5, dfrA1, and qacL. These genes were found in the class 1 integron gene cassettes in the Holtemme river, highlighting the persistence of ARGs downstream from wastewater treatment plant discharge.
In silico analyses of diversity and dissemination of antimicrobial resistance genes and mobile genetics elements, for plasmids of enteric pathogens.
The study identifies a diverse array of antimicrobial resistance (AMR) genes across various plasmid replicon types in enteric pathogens, highlighting the prevalence of resistance genes in plasmids such as IncHI2, IncN, IncA/C, IncP, IncHI1, and IncFIA. Key AMR genes include aac(3)-IId, aac(3)-IIg, aac(6')-Ib3, aadA1, aadA5, aph(3'')-Ib, bla CMY-2, bla CTX-M-27, bla NDM-1, mcr-9.1, and others, which confer resistance to antibiotics such as gentamicin, cephalosporins, carbapenems, colistin, and tetracycline.
Metagenomic Insight into Microbiome and Antibiotic Resistance Genes of High Clinical Concern in Urban and Rural Hospital Wastewater of Northern India Origin: a Major Reservoir of Antimicrobial Resistance.
The study identified several clinically relevant antibiotic resistance genes (ARGs) in hospital wastewater samples from northern India, including bla NDM-1, mcr-5.1, aac(6')-Ib, aph(3')-I, erm, and sul1. These genes were found to confer resistance to various antibiotics such as carbapenems, colistin, aminoglycosides, macrolides, lincosamides, streptogramin B, and sulfonamides.
Silver nanoparticles enhance the efficacy of aminoglycosides against antibiotic-resistant bacteria.
The study identifies several AMR genes, including mcr-1, mcr-3, mcr-4, aadA5, catA1, bla CMY-2, bla CTX-M-55, dfrA17, fosA, mph(A), rmtB, strA, strB, sul1, sul2, bla TEM-1B, and bla CMY-48, which confer resistance to various antibiotics in different bacterial strains.
oprL Gene Sequencing, Resistance Patterns, Virulence Genes, Quorum Sensing and Antibiotic Resistance Genes of XDR Pseudomonas aeruginosa Isolated from Broiler Chickens.
The study identified XDR P. aeruginosa strains from broiler chickens in Egypt, which harbor multiple antibiotic resistance genes including bla TEM, bla CTX-M, bla OXA-1, aad A1, tet A, and sul 1. These strains showed resistance to multiple antimicrobial classes.
Systematic In Silico Assessment of Antimicrobial Resistance Dissemination across the Global Plasmidome.
The study identifies various antimicrobial resistance genes (ARGs) and their dissemination patterns across the global plasmidome using %GC content analysis. Key findings include the identification of genes such as sul, dfrA, qnr, CTX-M, OXA, APH(3'), ANT(3''), AAC(6'), mcr, erm, tet, and qac, which are associated with resistance to sulfonamides, trimethoprim, quinolones, beta-lactams, aminoglycosides, polymyxins, macrolides, lincosamides, streptogramins, tetracyclines, and quaternary ammonium compounds.
Whole-Genome Sequencing Snapshot of Clinically Relevant Carbapenem-Resistant Gram-Negative Bacteria from Wastewater in Serbia.
The study identified several AMR genes and mutations in carbapenem-resistant Gram-negative bacteria from wastewater in Serbia, highlighting the presence of multidrug-resistant isolates with resistance to various antibiotics, including carbapenems, aminoglycosides, fluoroquinolones, and colistin.
Characterization of Extensively Drug-Resistant Salmonella enterica Serovar Kentucky Sequence Type 198 Isolates from Chicken Meat Products in Xuancheng, China.
Extensively drug-resistant Salmonella enterica serovar Kentucky ST198 isolates from chicken meat products in Xuancheng, China, were characterized. These isolates carried multiple resistance genes, including bla CTX-M-55, bla TEM-1B, aac(3)-IId, aadA17, rmtB, tet(A), floR, lnu(F), arr-2, qnrS1, sul1, mph(A), and fosA3, and mutations in gyrA (S83F, D87N) and parC (S80I), leading to resistance against several antimicrobial agents.
Antibiotic resistance and resistance mechanism of Corynebacterium kroppenstedtii isolated from patients with mastadenitis.
The study identified erm(X), sul(1), and tet(W) genes in Corynebacterium kroppenstedtii isolates, which confer resistance to erythromycin, clindamycin, trimethoprim-sulfamethoxazole, and tetracycline. Additionally, mutations in the gyrA gene were linked to ciprofloxacin resistance.
Emergence of colistin resistance and characterization of antimicrobial resistance and virulence factors of Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae isolated from hybrid red tilapia cage culture.
The study identified several AMR genes in Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae isolated from hybrid red tilapia. Notably, mcr-3 was found in A. hydrophila, and qnrS, tetA, blaTEM, and floR were prevalent in Salmonella spp. No colistin resistance genes were detected in V. cholerae.
Multidrug-resistant extended spectrum β-lactamase (ESBL)-producing Escherichia coli from farm produce and agricultural environments in Edo State, Nigeria.
The study identified various AMR genes in ESBL-producing E. coli isolates from agricultural farms and open markets in Edo State, Nigeria, including blaTEM, blaCTX-M-1, blaCTX-M-15, tetM, tetA, tetB, sul1, sul2, sul3, ant(4')-Ia, aacC(3)-1, qnrA, qnrB, qnrC, qnrS, cat::pC194, cat::pC221, intI1, and intI2. These genes conferred resistance to multiple antibiotics, indicating the presence of multidrug-resistant E. coli in the studied environments.
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.
The study identified various AMR genes in sepsis-causing bacteria, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others, highlighting the complexity of AMR in these pathogens.
Quantification of the mobility potential of antibiotic resistance genes through multiplexed ddPCR linkage analysis.
The study developed a multiplexed ddPCR method to quantify the physical linkage between the sulfonamide resistance gene sul1 and the Class 1 integron integrase gene intI1, demonstrating its effectiveness in measuring gene linkage in environmental samples.
Multidrug-resistant Aeromonas bacteria prevalence in Nile tilapia broodstock.
The study identified multidrug-resistant Aeromonas hydrophila strains in Nile tilapia broodstock, with resistance genes sul1, tetA, qnrs, and ermB detected in the isolates.
Genomic Diversity, Antimicrobial Susceptibility, and Biofilm Formation of Clinical Acinetobacter baumannii Isolates from Horses.
The study identified multiple AMR genes in equine Acinetobacter baumannii isolates, including beta-lactamases (bla OXA-51-like, bla ADC-25, bla TEM-1D), sulfonamide resistance genes (sul1, sul2), chloramphenicol resistance genes (catA1, ABUW 0982), tetracycline resistance genes (tet(A), tet(B), tet(39)), and aminoglycoside modifying enzymes (aph(3′)-Ia, aph(3`)-Ic, aph(6)-Id, aac(3)-Ia). Additionally, eight novel OXA-51-like variants (OXA-970 to OXA-977) were characterized.
Antimicrobial Resistance in Vaginal Bacteria in Inseminated Mares.
The study identified several AMR genes in E. coli, S. equisimilis, and S. simulans, including sul1, sul2, dfrA1, dfrA14, tet(A), mdf(A), blaEC-5, blaTEM-1, blaTEM-1B, blaEC, catB3, aadA5, aph(6)-ld, lsaC, and blaZ, which conferred resistance to various antibiotics.
Genome Analysis of Pseudomonas aeruginosa Strains from Chronically Infected Patients with High Levels of Persister Formation.
The study identified multiple AMR genes and efflux pump systems in P. aeruginosa persister isolates, highlighting their multidrug-resistant phenotype and biofilm-forming capabilities.
Prevalence and Characterization of Salmonella Isolated from Chickens in Anhui, China.
The study identified several AMR genes in Salmonella isolates from chickens in Anhui, China, including blaTEM, blaCMY-2, aadA, strA, aph(3')-IIa, aac(6')-Ib-cr, qnrB, qnrS, sul1, sul2, tetA, tetB, cat1, and floR. These genes were associated with resistance to various antibiotics such as ampicillin, cephalosporins, streptomycin, gentamicin, amikacin, fluoroquinolones, sulfamethoxazole, tetracycline, chloramphenicol, and florfenicol.
Detection of antibiotic-resistant canine origin Escherichia coli and the synergistic effect of magnolol in reducing the resistance of multidrug-resistant Escherichia coli.
The study identified multiple antibiotic resistance genes in canine-derived E. coli, including blaTEM-1, aac(6')-Ib-cr, TetA, Sul, blaCTX-M-1, QnrS, and TetM. It also demonstrated that magnolol enhances the susceptibility of multidrug-resistant E. coli to cefquinome.
High frequency of NDM-1 and OXA-48 carbapenemase genes among Klebsiella pneumoniae isolates in central Iran.
The study identified high frequencies of bla TEM, bla CTX-M1, bla SHV, bla CTX-M15, bla CIT, bla CMY-2, bla NDM, bla OXA-48, qnrB, qnrS, qnrA, tetA, tetB, sul1, sul2, int1, and int2 genes in Klebsiella pneumoniae isolates from central Iran, highlighting the prevalence of multidrug-resistant and carbapenem-resistant strains.
Antimicrobial resistance and genomic characterization of Salmonella enterica isolates from chicken meat.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from chicken meat, including aminoglycoside, beta-lactam, quinolone, tetracycline, sulfonamide, and phenicol resistance genes. These genes were detected using whole genome sequencing and correlated with phenotypic resistance profiles.
High Genetic Diversity of Carbapenem-Resistant Acinetobacter baumannii Isolates Recovered in Nigerian Hospitals in 2016 to 2020.
The study identified blaOXA-23 and blaNDM-1 as the most common carbapenem resistance genes in Acinetobacter baumannii isolates from Nigerian hospitals, along with several other AMR genes and mutations contributing to multidrug resistance.
Brevundimonas brasiliensis sp. nov.: a New Multidrug-Resistant Species Isolated from a Patient in Brazil.
The study characterizes Brevundimonas brasiliensis sp. nov., a novel species isolated from a neonatal intensive care unit, and identifies several antimicrobial resistance genes and mutations associated with resistance to β-lactams, aminoglycosides, fluoroquinolones, and colistin.
Genome profiling of uropathogenic E. coli from strictly defined community-acquired UTI in paediatric patients: a multicentric study.
The study identified multiple AMR genes in E. coli isolates from pediatric UTI cases, including bla CTX-M-15, bla NDM-5, bla OXA-1, and others, highlighting the presence of high-risk clones like ST131 and ST167.
Analysis of antibiotic resistance gene cassettes in a newly identified Salmonella enterica serovar Gallinarum strain in Korea.
The study identifies the presence of aadA1 and sul1 resistance genes in Salmonella enterica serovar Gallinarum strain SG4021. However, the insertion of ISCR16 downstream of the sul1 promoter leads to reduced expression of sul1, resulting in sulfonamide sensitivity despite the presence of the gene.
Phenotypic and Genotypic Characteristics of Antimicrobial Resistance in Citrobacter freundii Isolated from Domestic Ducks (Anas platyrhynchos domesticus) in Bangladesh.
The study identified multiple AMR genes in Citrobacter freundii isolates from domestic ducks in Bangladesh, including beta-lactamases (bla TEM-1, bla CMY-2, bla CMY-9, bla CTX-M-14), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tetA, tetB), fluoroquinolone resistance genes (qnrA, qnrB, qnrS), and an aminoglycoside resistance gene (aacC4).
Occurrence of High-Risk Clonal Lineages ST58, ST69, ST224, and ST410 among Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Healthy Free-Range Chickens (Gallus gallus domesticus) in a Rural Region in Tunisia.
The study identified high-risk clonal lineages ST58, ST69, ST224, and ST410 among ESBL-producing E. coli isolates from free-range chickens in Tunisia. Key AMR genes included bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, aac(6')-Ib-cr, qnrS, qnrB, tetB, tetA, sul1, sul2, and mcr-2.
Antibiotic-Resistant Desulfovibrio Produces H(2)S from Supplements for Animal Farming.
The study identifies multiple antibiotic resistance genes in Desulfovibrio vulgaris L2, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and mercury resistance genes, highlighting its potential role in spreading antibiotic resistance in agricultural environments.
Molecular Characterization of Extensively Drug Resistant Salmonella Enterica Serovar Typhi Clinical Isolates from Lahore, Pakistan.
The study identified multiple AMR genes in XDR Salmonella Typhi isolates from Lahore, Pakistan, including blaTEM-1, catA1, sul1, dhfR7, qnrS, gyrA, gyrB, parC, parE, blaCTX-M-U, blaCTX-M-1, and blaCTX-M-15, which confer resistance to various antibiotics such as ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, fluoroquinolones, and third-generation cephalosporins.
Extensively Drug-Resistant Shigella flexneri 2a, California, USA, 2022
The study identifies multiple AMR genes in an extensively drug-resistant Shigella flexneri 2a isolate, including blaCTX-M-15, blaOXA-1, mph(A), qnrS1, tet(B), dfrA17, sul1, and gyrA D87N+S83L, which contribute to resistance against various antibiotics. Whole-genome sequencing confirmed the presence of these genes and guided effective treatment with fosfomycin.
Molecular epidemiology of enterically colonizing Escherichia coli with resistance against third-generation cephalosporins isolated from stool samples of European soldiers with concomitant diarrhea on deployment in Western African Mali.
The study identified bla CTX-M-15 and bla TEM-1b as the primary genes responsible for third-generation cephalosporin resistance in E. coli isolates from European soldiers in Mali. Additionally, several quinolone resistance genes including qnrS1, gyrA S83L, gyrA D87N, parE S458T, parE S458A, and parC S80I were found. Trimethoprim-sulfamethoxazole resistance was mediated by sul1, sul2, dfrA1, dfrA5, dfrA14, and dfrA17. Gentamicin resistance was associated with aph6-Id, aph3-Ib, aac3-IId, aadA5, and aac6-Ib-cr5. Tetracycline resistance was conferred by tetA, tetB, and tetD.
Antimicrobial resistance and molecular characterization of Escherichia coli isolated from bovine mastitis samples in Nghe An province, Vietnam.
The study identified tetracycline resistance genes tetA and tetB, sulfonamide resistance genes sul1 and sul2, and no extended-spectrum beta-lactamase (ESBL) genes in E. coli isolates from bovine mastitis in Vietnam.
Genome-Based Retrospective Analysis of a Providencia stuartii Outbreak in Rome, Italy: Broad Spectrum IncC Plasmids Spread the NDM Carbapenemase within the Hospital.
The study identifies the presence of bla NDM-1 and rmtC genes on an IncC plasmid in Providencia stuartii, contributing to extensive drug resistance. Additional resistance genes such as aac(6')-Ib3, sul1, bla CMY-6, tet(B), catA3, and aac(2')-Ia were also found.
The First Report of Escherichia coli and Klebsiella pneumoniae Strains That Produce Both NDM-5 and OXA-181 in Jiangsu Province, China.
The study reports the first identification of Escherichia coli and Klebsiella pneumoniae strains producing both NDM-5 and OXA-181 carbapenemases in pediatric patients in China, highlighting the potential for rapid dissemination of these resistance genes.
Multidrug-resistant non-typhoidal Salmonella of public health significance recovered from migratory birds in Bangladesh.
The study identified multidrug-resistant non-typhoidal Salmonella in migratory birds in Bangladesh, highlighting the presence of various AMR genes such as blaCARB-2, floR, sul1, tet(G), dfrA1, and mutations in gyrA and parC associated with quinolone resistance.
Molecular epidemiology and characterization of antimicrobial-resistant Staphylococcus haemolyticus strains isolated from dairy cattle milk in Northwest, China.
The study identified several antimicrobial resistance genes in Staphylococcus haemolyticus strains isolated from dairy cattle milk in Northwest, China, including mphC, ermB, floR, aadD, sul1, and gyrA, which confer resistance to erythromycin, florfenicol, gentamicin, trimethoprim-sulfamethoxazole, and ciprofloxacin.
Clinical and Bacterial Characteristics Associated with Glove and Gown Contamination by Carbapenem-Resistant Klebsiella pneumoniae in the Health Care Setting.
The study identified various carbapenem resistance genes such as bla KPC, bla KPC-3, bla KPC-2, bla NDM, and bla OXA-232, as well as aminoglycoside resistance genes like aph(6)-Id, aph(3″)-Ib, and others. It also found sulfonamide resistance genes (sul1, sul2, sul3), beta-lactam resistance genes (bla TEM, bla OXA), and quinolone resistance genes (qnrS1).
Genomic Characteristics of a Multidrug-Resistant ST648 Escherichia coli Isolate Co-Carrying bla(KPC-2) and bla(CTX-M-15) Genes Recovered from a Respiratory Infection in China.
The study identifies a multidrug-resistant ST648 Escherichia coli isolate carrying bla(KPC-2) and bla(CTX-M-15) genes, along with other resistance genes such as tet(B), mdf(A), mph(A), dfrA17, aadA5, and sul1.
Genomic epidemiology of nosocomial carbapenemase-producing Citrobacter freundii in sewerage systems in the Helsinki metropolitan area, Finland.
The study identified bla KPC-2 and bla VIM-1 carbapenemase genes, along with various other AMR genes such as aac(6′)-If, aph(6)-Id, aac(3)-IIa, aadA1, dfrA1, sul2, sat2, qnrB, cmlA5, bla OXA-9, bla CMY-79, bla CMY-116, bla TEM-1A, bla CMY-117, bla OXA-10, bla CFE, bla CMY-100, aac(6′)-Ib, aadA2, sul1, qnrS1, qnrB9, mph(E), msr(E), aac(6′)-Iic, and dfrA16 in carbapenemase-producing Citrobacter freundii isolates from hospital environments and municipal wastewater in Finland.
A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia.
The study identifies multiple antimicrobial resistance (AMR) genes in Salmonella enterica serovar Concord, including sul1, sul2, blaCTX-M-15, qnrA1, qnrB2, and mph(A), which contribute to multidrug resistance (MDR), extensive drug resistance (XDR), and pandrug resistance (PDR).
Whole-Genome Sequencing Revealed the Fusion Plasmids Capable of Transmission and Acquisition of Both Antimicrobial Resistance and Hypervirulence Determinants in Multidrug-Resistant Klebsiella pneumoniae Isolates.
The study identified multiple antimicrobial resistance genes and hypervirulence determinants in multidrug-resistant Klebsiella pneumoniae isolates, highlighting the role of fusion plasmids in the transmission of these traits.
Whole-genome sequencing and phylogenetic analysis capture the emergence of a multi-drug resistant Salmonella enterica serovar Infantis clone from diagnostic animal samples in the United States.
The study identifies a multidrug-resistant Salmonella infantis clone harboring a pESI-like megaplasmid with the blaCTX-M-65 gene, which confers resistance to ceftriaxone and ampicillin. Several other AMR genes, including aac(3)-IVa, aadA1, aph(4)-Ia, sul1, tetA, floR, dfrA14, and fosA, were also characterized.
Molecular Characterization and Prevalence of Antimicrobial-Resistant Escherichia coli Isolates Derived from Clinical Specimens and Environmental Habitats.
The study identified several AMR genes in E. coli isolates from clinical and environmental sources, including bla CTX-M-group 1, bla CTX-M-group 9, bla TEM, bla SHV, bla OXA-48, bla CMY-2, bla FOX, and sul1. These genes conferred resistance to various antibiotics such as beta-lactams, sulfamethoxazole-trimethoprim, and others.
Evaluation of Enterotoxins and Antimicrobial Resistance in Microorganisms Isolated from Raw Sheep Milk and Cheese: Ensuring the Microbiological Safety of These Products in Southern Brazil.
The study identified several antimicrobial resistance genes, including tetM, ermB, strA, tetL, sul1, sul2, and AAC(6)', in Staphylococcus spp. isolated from raw sheep milk and cheese in southern Brazil. These genes conferred resistance to various antibiotics, highlighting the prevalence of antimicrobial resistance in these microorganisms.
Characterization of microbial community and antibiotic resistome in intra urban water, Wenzhou China.
The study identified several antimicrobial resistance genes (ARGs) in urban water samples from Wenzhou, China, including intI1, tetA, ermA, ermB, qnrB, sul1, sul2, blaSHV, and blaCTX-M. These genes were found to be associated with different bacterial species and were linked to resistance against various antibiotics such as tetracyclines, erythromycin, fluoroquinolones, sulfonamides, and beta-lactams.
The evolutionary mechanism of non-carbapenemase carbapenem-resistant phenotypes in Klebsiella spp.
The study identified bla DHA-1 as a critical gene for carbapenem resistance in K. quasipneumoniae FK688, and showed that its loss leads to decreased resistance. Other resistance genes such as qnrB4, tetA[B], arr-3, dfrA27, aadA16, qacΔE1, and sul1 were also found on the pNAR1 plasmid.
Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
The study characterizes the molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics mediated by sul genes (sul1, sul2, sul3). These genes encode sulfonamide-insensitive dihydropteroate synthase enzymes that confer broad resistance to sulfonamides.
From Farm to Fork: Persistence of Clinically Relevant Multidrug-Resistant and Copper-Tolerant Klebsiella pneumoniae Long after Colistin Withdrawal in Poultry Production.
The study identified silA and pcoD genes associated with copper tolerance in Klebsiella pneumoniae isolates from poultry, and numerous chromosomal mutations linked to colistin resistance.
Fecal antibiotic resistance genes were transferred through the distribution of soil-lettuce-snail food chain.
The study identified several antibiotic resistance genes (ARGs) such as aacA43, mel_1, vanRB, tetM, tnpA-2, sul1, sul2, ermF, and vatB that were transferred through the soil-lettuce-snail food chain. These genes conferred resistance to various antibiotics including aminoglycosides, tetracyclines, sulfonamides, MLSB, and vancomycin.
Expansion of healthcare-associated hypervirulent KPC-2-producing Klebsiella pneumoniae ST11/KL64 beyond hospital settings.
Two carbapenem-resistant K. pneumoniae strains (PINH-4250 and PINH-4900) were recovered from the Pinheiros River, carrying the blaKPC-2 carbapenemase gene and other resistance determinants. They exhibited a broad resistome and hypervirulent behavior.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
Whole genome sequence analysis of Aeromonas spp. isolated from ready-to-eat seafood: antimicrobial resistance and virulence factors.
The study identified various AMR genes in Aeromonas strains isolated from ready-to-eat seafood, including beta-lactamases (bla OXA-12, bla OXA-780, bla OXA-427, bla OXA-956, cphA1, cphA2, cphA5), quinolone resistance gene qnrS2, sulfonamide resistance gene sul1, aminoglycoside resistance gene aadA1, tetracycline efflux pump tet(E), and efflux pump qacEΔ1.
Dominance of Escherichia coli sequence types ST73, ST95, ST127 and ST131 in Australian urine isolates: a genomic analysis of antimicrobial resistance and virulence linked to F plasmids.
The study identified various antimicrobial resistance genes in E. coli isolates from Australian urine samples, including blaCTX-M-15, blaCTX-M-14, blaTEM-28, sul1, sul2, sul3, dfrA17, dfrA5, dfrA1, dfrB4, tetA, tetB, mphA, cmlA1, cmlA5, catB3, sat2, qnrD1, fosA7, aac(3)-IId, aac(3)-IIe, aph(3')-IIa, aph(6)-Id, ant(3'')-IIa, intI1, and intI2. These genes were associated with resistance to various antibiotics such as beta-lactams, sulfonamides, trimethoprim, tetracycline, macrolides, chloramphenicol, streptothricin, quinolones, fosfomycin, and aminoglycosides.
Role of a typical swine liquid manure treatment plant in reducing elements of antibiotic resistance.
The study identified and characterized several antibiotic resistance genes (ARGs) in swine wastewater treatment plants, including blaTEM, ermB, qnrB, sul1, and tetA, which were found to be present in the raw wastewater and showed significant reductions after anaerobic digestion.
Chromosome-Borne CTX-M-65 Extended-Spectrum β-Lactamase-Producing Salmonella enterica Serovar Infantis, Taiwan.
Case of Extensively Drug-Resistant Shigella sonnei Infection, United States
The study reports a case of extensively drug-resistant Shigella sonnei infection in an immunocompromised patient, highlighting the challenge of identifying XDR strains using traditional microbiological methods and emphasizing the need for whole-genome sequencing for accurate diagnosis. The isolate exhibited resistance to all first-line antimicrobials, including ciprofloxacin, azithromycin, and ceftriaxone, and carried several AMR genes such as blaCTX-M-27, qnrB19, mph(A), sul1, sul2, dfrA1, dfrA17, and tet(A).
Acinetobacter baumannii Global Clone-Specific Resistomes Explored in Clinical Isolates Recovered from Egypt.
The study identified several AMR genes and mutations in Acinetobacter baumannii isolates from Egypt, including blaOXA-23, ISAb1-amplified_blaADC, blaNDM-1, blaGES-11, armA, aac(6')-Ib9, aph(3')-VI, and sul1, along with mutations in adeS, baeS, and carO contributing to tigecycline and carbapenem resistance.
Incidence and Genomic Background of Antibiotic Resistance in Food-Borne and Clinical Isolates of Salmonella enterica Serovar Derby from Spain.
The study identified several AMR genes, including aadA2, sul1, tet(A), tet(B), tet(C), blaTEM-1, and fosA7.3, in Salmonella enterica serovar Derby isolates from Spain. These genes were associated with resistance to streptomycin, sulfonamides, tetracycline, ampicillin, and fosfomycin. Additionally, a point mutation in the gyrA gene was linked to nalidixic acid resistance.
Genomic Characterization of Fecal Escherichia coli Isolates with Reduced Susceptibility to Beta-Lactam Antimicrobials from Wild Hogs and Coyotes.
The study identified beta-lactamase genes (blaCMY-2, blaCTX-M-55, blaCTX-M-27), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aac(3)-IId, aadA5, ant(3")-Ia, aph(3')-Ia, aph(3")-lb, aph(6)-ld), sulfonamide resistance genes (sul1, sul2, sul3), amphenicol resistance gene (floR), trimethoprim resistance genes (dfrA1, dfrA17), and MLS resistance genes (Inu(F), erm(B), mph(A)) in E. coli isolates from coyotes and wild hogs. Additionally, chromosomal mutations in ampC, gyrA, parC, and parE were found to confer resistance to beta-lactam and quinolone antibiotics.
Molecular characterization of multidrug resistant Acinetobacter baumannii clinical isolates from Alexandria, Egypt.
The study identified various AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Alexandria, Egypt, including bla OXA-51-like variants, bla OXA-23, bla NDM-1, bla PER-7, bla GES-like, and others, highlighting the widespread resistance to beta-lactams, aminoglycosides, tetracyclines, and other antibiotics.
Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
The study identified various AMR genes in multidrug-resistant Gram-negative pathogens, highlighting the prevalence of bla CTX-M-15, bla CMY-42, bla NDM-5, aadA, bla TEM-1B, bla OXA-232, bla NDM-1, rmtB, rmtC, bla VEB, bla VIM-2, aph(3'), strA/B, bla OXA-23, aph (3′), catB, dfrB, bla VIM-2, fosA, oqxA, oqxB, bla OXA-23, bla CARB, bla OXA-91, bla OXA-51, bla PAO, bla SHV, aph (3′)-Ib, aph (6)-Id, mphE, msrE, ermB, mphA, aadA, rmtB, qnrB, dfrA, sul1, sul2, and fosA7.
Extended-spectrum β-lactamase-producing E. coli from retail meat and workers: genetic diversity, virulotyping, pathotyping and the antimicrobial effect of silver nanoparticles.
The study identified multiple AMR genes in ESBL-producing E. coli from retail meat and workers, including bla IMP, bla TEM, bla CTX-M-1, bla VIM, bla NDM, tetA (A), tetA (B), sul, flo R, and mcr-1. These genes conferred resistance to various antibiotics such as β-lactams, tetracycline, sulfonamides, fluoroquinolones, and colistin.
Genomic Analysis of an Escherichia coli Sequence Type 167 Isolate Harboring a Multidrug-Resistant Conjugative Plasmid, Suggesting the Potential Transmission of the Type Strains from Animals to Humans.
The study identifies multiple AMR genes in the E. coli ST167 isolate ECO3183, including bla_NDM-5, aac(6')-Ib-cr, aph(3')-Ia, aph(3")-Ib, aac(3)-IId, sul1, sul2, dfrA27, tet(A), floR, mph(A), and arr-3, which contribute to its multidrug-resistant phenotype. Additionally, a chromosomal gyrA mutation (p.S83L) was associated with fluoroquinolone resistance.
Genomic epidemiology and antibiotic susceptibility profiling of uropathogenic Escherichia coli among children in the United States.
The study identified AMR genes blaCTX-M-15, sul1, dfrA12, and dfrA17 in ST131 E. coli isolates from children with UTIs, and mutations in gyrA and parC that confer fluoroquinolone resistance.
High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China.
The study identified a high rate of multidrug resistance in E. coli isolates from diseased ducks in China, with several AMR genes such as bla TEM, bla CTX-M, qnrS, aadA1, sul1, sul2, tet A, floR, mcr-1, intI1, and intI2 being characterized.
Comparing antimicrobial resistant genes and phenotypes across multiple sequencing platforms and assays for Enterobacterales clinical isolates.
The study compared antimicrobial resistance genes and phenotypes across different sequencing platforms and assays for Enterobacterales clinical isolates, highlighting the detection of various AMR genes such as blaKPC-2, qnrB, oqxA, oqxB, sul1, sul2, drfA*, aac(3)-IIe, and blaCTX-M-1, which conferred resistance to multiple antibiotics.
Poultry production as the main reservoir of ciprofloxacin- and tigecycline-resistant extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198.2-2 causing human infections in China.
The study identifies several AMR genes and mutations in Salmonella enterica serovar Kentucky ST198.2-2, including blaCTX-M-14b, blaCTX-M-55, blaTEM-1B, aadA7, aph(3')-Ia, aac(3)-IId, rmtB, tet(A), sul1, dfrA14, floR, lnu(F), mph(A), arr-2, and fosA3, which confer resistance to various antibiotics. Mutations in gyrA and parC also contribute to fluoroquinolone resistance.
Prevalence and molecular characterization of cefotaxime-resistant Salmonella strains recovered from retail meat samples in Shenzhen, China, during 2014-2017.
The study identified several beta-lactamase genes, including bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, bla CTX-M-130, bla CTX-M-27, and bla CMY-2, as well as other resistance genes such as qnrS1, qnrB6, mph(A), oqxAB, mcr-1.1, tet(A), tet(B), sul1, sul2, sul3, aac(6')-Ib, aph(3")-Ib, floR, drfA14, drfA1, and Inu(F), which contribute to cefotaxime resistance in Salmonella strains isolated from retail meat samples in Shenzhen, China.
Occurrence of Acinetobacter baumannii genomic resistance islands (AbGRIs) in Acinetobacter baumannii strains belonging to global clone 2 obtained from COVID-19 patients.
The study identified several AMR genes within AbGRIs in GC2 A. baumannii isolates from COVID-19 patients, including strA, strB, tetA(B), tetR(B), sul2, oxa23, aacC1, aadA1, blaTEM, armA, aacA4, aphA1b, and sul1, which confer resistance to various antibiotics such as aminoglycosides, tetracyclines, sulfonamides, carbapenems, and beta-lactams.
Various arrangements of mobile genetic elements among CC147 subpopulations of Klebsiella pneumoniae harboring bla(NDM-1): a comparative genomic analysis of carbapenem resistant strains.
The study identified bla(NDM-1), bla(OXA-48), qnrS1, aac(6')-Ib-cr, armA, bla(CTX-M-15), sul1, dfrA, aadA5, and qnrB1 as key resistance genes in CC147 subpopulations of Klebsiella pneumoniae. Additionally, a mutation in ompK36 was found to contribute to decreased susceptibility to antibiotics.
Genetic Diversity and Antimicrobial Resistance of Extraintestinal E. coli Populations Pre- and Post-Antimicrobial Therapy on Broilers Affected by Colisepticemia.
The study identified several AMR genes and mutations in extraintestinal E. coli populations from broilers treated with enrofloxacin. Key findings include the presence of qnrB19 and qnrS1 genes, which confer fluoroquinolone resistance, and mutations in gyrA, parC, and parE genes associated with fluoroquinolone resistance. Additionally, multiple other AMR genes were detected, indicating multidrug resistance.
Comparison of Cefotaxime-Resistant Escherichia coli and sul1 and intI1 by qPCR for Monitoring of Antibiotic Resistance of Wastewater, Surface Water, and Recycled Water.
The study compared cefotaxime-resistant E. coli and the qPCR detection of sul1 and intI1 for monitoring antibiotic resistance in water environments. Both sul1 and intI1 showed strong correlations with cefR E. coli and were effective indicators of anthropogenic pollution and antibiotic resistance.
Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Causing Nosocomial Meningitis in the Neurological Intensive Care Unit.
The study identified various AMR genes in 37 A. baumannii strains causing nosocomial meningitis, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, macrolide resistance genes, phenicol resistance genes, sulfonamide resistance genes, rifamycin resistance genes, and antiseptic resistance genes.
Co-localization of clinically relevant antibiotic- and heavy metal resistance genes on plasmids in Klebsiella pneumoniae from marine bivalves.
The study identifies multiple antibiotic resistance genes (ARGs) and heavy metal resistance genes (HMRGs) co-localized on plasmids in Klebsiella pneumoniae isolated from marine bivalves, highlighting the potential for co-selection of these genes in the marine environment.
Regulation Transcriptional of Antibiotic Resistance Genes (ARGs) in Bacteria Isolated from WWTP.
The study identifies several antibiotic resistance genes (ARGs) in bacteria isolated from wastewater treatment plants, including sul, qnr, cat1, aadA1, sat-1, tetA, ermB, and act, which confer resistance to sulfonamides, quinolones, chloramphenicol, streptomycin/spectinomycin, kanamycin, tetracycline, macrolides, and beta-lactams, respectively.
Impact of corrosion inhibitors on antibiotic resistance, metal resistance, and microbial communities in drinking water.
Zinc orthophosphate increased antibiotic resistant bacteria (ARB) and antibiotic-resistance genes (ARGs), while sodium silicate decreased ARB and ARGs. The study identified sul1, sul2, qacEΔ1, and intI1 as key ARGs influenced by corrosion inhibitors.
Impact of corrosion inhibitors on antibiotic resistance, metal resistance, and microbial communities in drinking water.
Zinc orthophosphate increased antibiotic resistant bacteria (ARB) and antibiotic-resistance genes (ARGs), while sodium silicate decreased ARB and ARGs. The study identified sul1, sul2, qacEΔ1, and intI1 as key ARGs influenced by corrosion inhibitors.
Differential effects of wastewater treatment plant effluents on the antibiotic resistomes of diverse river habitats.
The study identifies aadA, sul1, and blaA as genes that show increased abundance in river water downstream of wastewater treatment plants, suggesting their potential as indicators of wastewater-related pollution.
Genomic Insights into Listeria monocytogenes: Organic Acid Interventions for Biofilm Prevention and Control.
The study identified several antimicrobial resistance genes in Listeria monocytogenes, including Cat, Ide, mrsA, lin, fosX, mprF, vgaL, sul, norB, GyrA, GyrB, ParC, ParEm, FepR, and radC, which confer resistance to various antibiotics such as chloramphenicol, macrolides, lincosamides, streptogramins, phosphonic acids, peptides, fluoroquinolones, and sulfonamides.
Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.
The study identifies mcr-1.1 as a plasmid-mediated colistin resistance gene and characterizes several chromosomal mutations in mgrB, arnT, pmrA, pmrB, pmrC, phoQ, and arnB that contribute to colistin resistance in K. pneumoniae isolates from Egypt.
Virulence Factors and Antimicrobial Resistance of Uropathogenic Escherichia coli EQ101 UPEC Isolated from UTI Patient in Quetta, Balochistan, Pakistan.
The study identified multiple antimicrobial resistance genes in the E. coli EQ101 isolate, including genes involved in antibiotic efflux, inactivation, and drug replacement. Key resistance genes include TolC, emrR, evgA, qacEdelta1, H-NS, cpxA, mdtM, aadA5, mphA, CTX-M-15, sul1, and dfrA14.
Co-integrate Col3m bla (NDM-1)-harboring plasmids in clinical Providencia rettgeri isolates from Argentina.
The study characterizes bla NDM-1-harboring plasmids in clinical Providencia rettgeri isolates from Argentina, highlighting the presence of various resistance genes such as bla NDM-1, aac(6')-Ib-cr5, aph(3')-Ia, aph(3')-VI, bla PER-2, qnr D1, sul1, sul2, arr3, catB3, floR, mph(E), msr(E), and tet(A).
Phenotypic and genotypic antimicrobial resistance correlation and plasmid characterization in Salmonella spp. isolates from Italy reveal high heterogeneity among serovars.
The study identified several antimicrobial resistance genes including blaTEM-1B, sul1, sul2, tetA, tetB, and others in Salmonella isolates from Italy, highlighting the diversity of resistance mechanisms among different serovars.
Antibiotic Resistance Mediated by Escherichia coli in Kuwait Marine Environment as Revealed through Genomic Analysis.
The study identified various antibiotic resistance genes in Escherichia coli isolates from Kuwait's marine environment, including beta-lactamases, aminoglycoside-modifying enzymes, fluoroquinolone resistance genes, sulfonamide resistance genes, tetracycline resistance genes, and macrolide resistance genes. Additionally, the MFS-type drug efflux gene mdfA was commonly found in E. coli isolates.
Polyclonal Multidrug ESBL-Producing Klebsiella pneumoniae and Emergence of Susceptible Hypervirulent Klebsiella pneumoniae ST23 Isolates in Mozambique.
The study identified multiple AMR genes in Klebsiella isolates, including bla CTX-M-15, bla TEM-1, bla SHV, and bla OXA-1, which confer resistance to beta-lactams. Other genes like aac(3)-IIa, aac(6')-Ib-cr, qnrB1, qnrB6, catA1, catA2, catB3, dfrA5, dfrA7, dfrA12, dfrA14, dfrA27, sul1, sul2, mph(A), tet(A), tet(D), fosA, ARR-3, and oqxAB were also found, contributing to resistance against aminoglycosides, quinolones, chloramphenicol, trimethoprim, sulfamethoxazole, macrolides, tetracycline, fosfomycin, rifampicin, and quinolones respectively. Mutations in ompK36, ompK37, and acrR were associated with resistance to cephalosporins and fluoroquinolones, while mutations in RamR were linked to tigecycline resistance.
Comparative Genomics Reveals Novel Species and Insights into the Biotechnological Potential, Virulence, and Resistance of Alcaligenes.
The study identifies multiple antimicrobial resistance genes in Alcaligenes species, particularly in clinical isolates, highlighting the presence of genes conferring resistance to β-lactams, aminoglycosides, sulfonamides, and other antibiotics.
Isolation and Characterization of the Acadevirus Members BigMira and MidiMira Infecting a Highly Pathogenic Proteus mirabilis Strain.
The study identifies multiple antibiotic resistance genes in the highly pathogenic Proteus mirabilis strain MCS, highlighting its multidrug-resistant profile. Key genes include tetA, aac(6')-Iq, aac(6')-Ib', aadA, dfrA1, blaOXA-9, blaCTX-M-2, vat, catA2, sul1, qacEdeltal, tetQ, blaTEM-135, aadA2, aph(3')-Ia, aph(6)-Id, aph(3'')-lb, and sulI.
First Detection and Molecular Characterization of Pseudomonas aeruginosa bla(NDM-1) ST308 in Greece.
The study reports the first detection of blaNDM-1-positive Pseudomonas aeruginosa ST308 in Greece, highlighting the presence of multiple resistance genes including blaNDM-1, blaPAO, blaOXA-10, blaOXA-488, and others, indicating multidrug resistance.
Molecular characterization of highly prevalent Escherichia coli and Escherichia marmotae resistant to extended-spectrum cephalosporins in European starlings (Sturnus vulgaris) in Tunisia.
The study identified several extended-spectrum beta-lactamase (ESBL) and AmpC resistance genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, bla CMY-2, and bla CMY-62, in Escherichia coli and Escherichia marmotae isolates from European starlings in Tunisia. Additionally, aminoglycoside resistance genes such as aph(6)-Id and aph(3″)-Ib, along with fosA3, sul1, sul2, sul3, drfA1, drfA17, tet(A), and qnrS1 were also characterized.
The scope of antimicrobial resistance in residential aged care facilities determined through analysis of Escherichia coli and the total wastewater resistome.
The study identified several AMR genes in E. coli isolates from residential aged care facilities, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-62, blaOXA-1, blaOXA-181, blaTEM-1, qnrS, aac(6')-Ib-cr, sul1, sul2, and dfrA1, which confer resistance to various antibiotics such as cephalosporins, fluoroquinolones, and sulfonamides.
SHIP: identifying antimicrobial resistance gene transfer between plasmids.
SHIP identifies horizontally transferred antimicrobial resistance (AMR) gene regions between plasmids, including a multi-resistant complex class 1 integron in Escherichia coli and Klebsiella pneumoniae, and a tetracycline resistance region in Enterococcus faecalis.
Polymorphism and mutational diversity of virulence (vcgCPI/vcgCPE) and resistance determinants (aac(3)-IIa, (aacC2, strA, Sul 1, and 11) among human pathogenic Vibrio species recovered from surface waters in South-Western districts of Uganda.
The study identified various nucleotide variations in virulence determinants of V. vulnificus (vcgCPI) and resistance genes (strA, aadA, aac(3)-IIa, aacC2, sul1, and sul11) among Vibrio isolates.
Pathognomonic features of Pasteurella multocida isolates among various avian species in Sharkia Governorate, Egypt.
The study identified several AMR genes in Pasteurella multocida isolates, including ermX (erythromycin resistance), blaROB-1 (beta-lactam resistance), mcr-1 (colistin resistance), sul1 (sulfonamide resistance), dfrA1 (trimethoprim resistance), and tetH (tetracycline resistance).
Resistance profiles, virulence and antimicrobial resistance genes of XDR S. Enteritidis and S. Typhimurium.
The study identified multiple antimicrobial resistance genes including blaTEM, blaCTX-M, blaNDM, sul1, tetA, aadA1, and ereA in XDR S. Enteritidis and S. Typhimurium isolates from diseased broilers. These genes conferred resistance to various antibiotics such as beta-lactams, sulfonamides, tetracyclines, and aminoglycosides.
Extensive Expression of the Virulome Related to Antibiotic Genotyping in Nosocomial Strains of Klebsiella pneumoniae.
The study identified several antibiotic resistance genes in multidrug-resistant Klebsiella pneumoniae strains, including beta-lactamases (bla TEM, bla SHV, bla CITM, bla CTXM-1), tetracycline resistance (tetA), sulfonamide resistance (sul1), aminoglycoside resistance (aac(3)-IV, aadA1), and others.
The multidrug-resistant Pseudomonas fluorescens strain: a hidden threat in boar semen preservation.
The study identifies multiple acquired antibiotic resistance genes in the Pseudomonas fluorescens strain GXZC, including those conferring resistance to aminoglycosides, tetracyclines, and sulfonamides. The strain exhibits multidrug resistance and poses a risk in boar semen preservation.
Domestically Acquired NDM-1-Producing Pseudomonas aeruginosa, Southern California, USA, 2023
The study reports a case of domestically acquired NDM-1-producing Pseudomonas aeruginosa in a transplant patient in southern California, highlighting the presence of multiple resistance genes including blaNDM-1, blaOXA-10, blaOXA-488, blaPDC-35, blaPME-1, aac(6')-Ib9, ant(3”)-IIa, aph(3′)-IIb, aph(3′)-VIa, catB3, catB7, cmlA9, fosA, tet(D), and sul1.
Genetic Characterization of Extensively Drug-Resistant Shigella sonnei Infections, Spain, 2021-2022.
The Molecular Characterization of bla(NDM-1)-Positive Acinetobacter baumannii Isolated in Central Greece.
The study identifies multiple AMR genes in blaNDM-1-positive Acinetobacter baumannii isolates, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, macrolide resistance genes, tetracycline resistance genes, trimethoprim resistance genes, and quaternary ammonium resistance genes.
Prioritization of Critical Factors for Surveillance of the Dissemination of Antibiotic Resistance in Pseudomonas aeruginosa: A Systematic Review.
The study identifies 25 critical mobile antibiotic resistance genes (ARGs) in Pseudomonas aeruginosa, including genes such as sul1, qacEΔ1, aac(6′)-Ib, bla VIM-1, and others, which are associated with various antibiotic classes and are linked to mobile genetic elements (MGEs).
Phenotypic and genomic characterization of Pseudomonas aeruginosa isolates recovered from catheter-associated urinary tract infections in an Egyptian hospital.
The study identified multiple AMR genes and mutations in Pseudomonas aeruginosa isolates from catheter-associated urinary tract infections in Egypt, including beta-lactamases, aminoglycoside-modifying enzymes, quinolone resistance proteins, and efflux pump systems. Additionally, a pBT2436-like megaplasmid was detected, which contributes to multidrug resistance.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Decoding the genetic structure of conjugative plasmids in international clones of Klebsiella pneumoniae: A deep dive into blaKPC, blaNDM, blaOXA-48, and blaGES genes.
The study characterizes the genetic structure of plasmids harboring major carbapenemase genes (blaKPC, blaNDM, blaOXA-48, and blaGES) in Klebsiella pneumoniae, identifying the most prevalent allele types and their co-occurrence with other resistance genes.
Resistome and virulome of high-risk pandemic clones of multidrug-resistant extra-intestinal pathogenic Escherichia coli (ExPEC) isolated from tertiary healthcare settings in Uganda.
The study identified various AMR genes in multidrug-resistant E. coli isolates, including blaCTX-M-15, blaTEM-1B, blaOXA-1, and others, which confer resistance to beta-lactams, aminoglycosides, sulfonamides, tetracyclines, macrolides, and quinolones. Additionally, chromosomal mutations in gyrA and parC were found to contribute to fluoroquinolone resistance.
CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic Escherichia coli.
The study identified several AMR genes carried on IncF plasmids in MDR ExPEC strains, including bla TEM-1, aac(3)-IId, tet(A), aph(6)-Id, aph(3')-Ib, mphA, sul1, sul2, aadA5, dfrA17, strAB, qacEdelta1, bla CTX-M-14, bla CTX-M-15, catB3, bla OXA-1, bla CTX-M-27, and aac(6')-Ib-cr5. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, sulfonamides, and chloramphenicol.
Genomic characterization of tigecycline-resistant Escherichia coli and Klebsiella pneumoniae isolates from hospital sewage.
The study identifies tet(X4) and tmexCD1-toprJ1 as key genes contributing to tigecycline resistance in E. coli and K. pneumoniae isolates from hospital sewage, highlighting the role of plasmid-mediated resistance and efflux pump overexpression.
Occurrence and temporal distribution of extended-spectrum β-lactamase-producing Escherichia coli in clams from the Central Adriatic, Italy.
The study identified several β-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV12, bla CMY-2, bla TEM-1B, bla TEM-106, and bla TEM-126, which confer resistance to various β-lactam antibiotics. Other resistance genes such as aac(6′)-Ib-cr, qnrS1, tet(A), tet(B), tet(M), aadA5, aadA2b, sul1, sul2, sul3, dfrA17, dfrA5, dfrA14, dfrA12, mph(A), cmlA1, catA2, aac(3)-IIa, aac(3)-IId, and lnu(F) were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates from clams in the Central Adriatic.
Prevalence and genomic characterization of Salmonella isolates from commercial chicken eggs retailed in traditional markets in Ghana.
The study identified several AMR genes and mutations in Salmonella isolates from chicken eggs in Ghana, including aadA1, aph(3")-Ib, aph(6)-Id, catA1, dfrA1, dfrA14, fosA7.2, qnrB19, sul1, sul2, and tet(A), as well as mutations in gyrA (D87N) and gyrA (S83Y).
Genetic characterization of a multidrug-resistant Salmonella enterica serovar Agona isolated from a dietary supplement in Germany.
The study identifies 23 antibiotic resistance genes (ARGs) in a multidrug-resistant Salmonella enterica serovar Agona isolate from a dietary supplement in Germany, conferring resistance to 12 different antibiotic classes. Key genes include blaSHV-12, aac(3)-Iig, aac(6')-Iic, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, dfrA19, qacEΔ1, ere(A), sul1, sul2, tet(D), mcr-9.1, catA2, arr, qnrS1, blaTEM-1, aac(3)-IIe, and floR.
The fate of antibiotic resistance genes during anaerobic digestion of sewage sludge with ultrasonic pretreatment.
The study investigated the effect of ultrasonic pretreatment on the fate of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) during anaerobic digestion of sewage sludge. It found that ultrasonic pretreatment significantly reduced the relative abundance of ARGs and MGEs, with 60 minutes of pretreatment achieving the highest removal rate of 41.70% for total ARGs.
Serovars, Virulence and Antimicrobial Resistance Genes of Non-Typhoidal Salmonella Strains from Dairy Systems in Mexico.
Shotgun Metagenomics-Guided Prediction Reveals the Metal Tolerance and Antibiotic Resistance of Microbes in Poly-Extreme Environments in the Danakil Depression, Afar Region.
The study identified numerous antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in the metagenomes of Lake Afdera and the Assale salt plain in the Danakil Depression. Key ARGs included beta-lactamases (ACC-1, OXA-58, OXA-363, OXA-212, NDM-17, OXA-134, ACT-29, LRA-19), efflux pumps (emrB, abeM, abeS, mgrA, adeJ, MexC, adeL, adeH), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet39, tetX, tetK), and others. MRGs included copper resistance genes (copC, copD), cadmium resistance gene (cadD), mercury resistance gene (merA), chromate resistance genes (chrB, chrA), nickel-cobalt-cadmium resistance genes (nccA, nccB), cobalt-zinc-cadmium resistance gene (czcD), arsenic resistance gene (arsO), lead resistance gene (pbrA), and mercury resistance genes (merB, merR, MIR).
Antimicrobial Resistant Bacteria Monitoring in Raw Seafood Retailed: a Pilot Study Focused on Vibrio and Aeromonas.
The study identified tetracycline, sulfamethoxazole, and trimethoprim/sulfamethoxazole resistance genes (tetD, tetB, tetM, tetE, sul1, sul2, and dfrA) in Vibrio and Aeromonas isolates from raw seafood samples in Japan.
Elimination of antibiotic-resistant bacteria and resistance genes by earthworms during vermifiltration treatment of excess sludge.
The study demonstrates that earthworms significantly reduce antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in sludge through mechanisms involving coelomic fluid and gut activity, with notable reductions in tetracycline and sulfonamide resistance genes.
Characteristics of antimicrobial resistance in Escherichia coli isolated from retail meat products in North Carolina.
The study identified several AMR genes in E. coli isolates from retail meat products in North Carolina, including aac(3)-IV, aadA1, aph(3'')-lb, blaTEM-1, tetB, and others, highlighting the prevalence of multidrug-resistant E. coli in ground turkey.
Determination of antibiotic resistance patterns and genotypes of Escherichia coli isolated from wild birds.
The study identified several AMR genes in E. coli isolates from wild birds, including tet(A), tet(B), strA/strB, aphA1, sul1, sul2, and sul3, which confer resistance to tetracycline, streptomycin, kanamycin, and sulfonamides.
Low temperatures do not impair the bacterial plasmid conjugation on poultry meat.
The study demonstrates that non-pathogenic E. coli can acquire an IncB/O-plasmid carrying multiple antimicrobial resistance genes through conjugation on poultry meat, even at low temperatures. This highlights the potential risk of antimicrobial resistance spread through food products.
Metagenomic identification of pathogens and antimicrobial-resistant genes in bacterial positive blood cultures by nanopore sequencing.
The study identified various antimicrobial resistance (AMR) genes in bacterial positive blood cultures using nanopore sequencing, demonstrating the effectiveness of this method in detecting resistance mechanisms and pathogens quickly.
Genomic Features of an MDR Escherichia coli ST5506 Harboring an IncHI2/In229/bla(CTX-M-2) Array Isolated from a Migratory Black Skimmer.
An MDR E. coli ST5506 strain was isolated from a migratory black skimmer, harboring a complex array including bla(CTX-M-2), bla(TEM-1C), aac(3)-VIa, aadA1, aph(3′)-Ia, sul1, dfrA27, and tetA, indicating resistance to various antimicrobials.
Plasmid content of carbapenem resistant Acinetobacter baumannii isolates belonging to five International Clones collected from hospitals of Alexandria, Egypt.
The study characterizes various AMR genes in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaPER-7, blaGES-11, blaGES-35, aph(3')-VI, aac(6')-Ib, sul1, sul2, mph(E), msr(E), armA, strA, strB, cmlA5, arr-2, ant(3'')-II, aadA1-pm, tet(B), tet(39), qacEΔ1, and dfrA7.
Characterization of nontyphoidal Salmonella strains from a tertiary hospital in China: serotype diversity, multidrug resistance, and genetic insights.
The study identified multidrug-resistant nontyphoidal Salmonella strains carrying bla CTX-M-15, qnrS1, sul1, sul2, and the mrkABCDF operon, highlighting the need for monitoring the spread of these resistance mechanisms.
Genomic Characterization of Two NDM-5-Producing Isolates of Klebsiella pneumoniae ST11 from a Single Patient.
The study identified two NDM-5-producing K. pneumoniae ST11 isolates from a single patient, highlighting the presence of multiple acquired antimicrobial resistance genes, including blaNDM-5, blaCTX-M-15, and rmtB, along with other resistance determinants.
Stenotrophomonas maltophilia complex: insights into evolutionary relationships, global distribution and pathogenicity.
The study identified 46 antimicrobial resistance genes (ARGs) in the Stenotrophomonas maltophilia complex (Smc), including aac(6')-Ib, ant(3'')-I, smeABC, smeRS, sul1, and sul2. These genes confer resistance to various antibiotics such as amikacin, gentamicin, ceftazidime, and trimethoprim/sulfamethoxazole. Notably, all 14 strains of S. geniculata were resistant to ceftazidime, highlighting the importance of monitoring resistance patterns in Smc species.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Genomic Characterization of a Plasmid-Free and Highly Drug-Resistant Salmonella enterica Serovar Indiana Isolate in China.
The study identifies 54 AMR genes and three AMR gene cassettes in the plasmid-free, highly drug-resistant Salmonella enterica serovar Indiana isolate S1467, contributing to resistance against multiple antimicrobial classes.
Distribution of bacterial community structures and spread of antibiotic resistome at industrially polluted sites of Mini River, Vadodara, Gujarat, India.
The study identified the presence of antibiotic resistance genes (ARGs) such as sul1, sul2, blaTEM, and aac(6')-Ib-Cr in the Mini River, highlighting the spread of antibiotic resistance in industrially polluted sites.
Genomic insights into ESBL-producing Escherichia coli isolated from non-human primates in the Peruvian Amazon.
The study identified three bla CTX-M variants (bla CTX-M-15, bla CTX-M-55, and bla CTX-M-65) and a broad resistome in ESBL-producing E. coli strains isolated from non-human primates in the Peruvian Amazon.
Whole-Genome Sequencing of an Escherichia coli ST69 Strain Harboring bla(CTX-M-27) on a Hybrid Plasmid.
The study identifies a multidrug-resistant E. coli ST69 strain carrying the bla(CTX-M-27) gene on a hybrid plasmid, along with various other antibiotic resistance genes such as aminoglycoside, macrolide, sulfonamide, tetracycline, and trimethoprim resistance genes.
Next generation antibiotic combinations to combat pan-drug resistant Klebsiella pneumoniae.
The study identified multiple AMR genes in the pan-drug resistant K. pneumoniae isolate CDC Nevada, including beta-lactamases (bla NDM-1, bla CMY-6, bla CTX-M-15, bla SHV-2), fosfomycin resistance gene (fosA), macrolide phosphotransferase (mphA), aminoglycoside acetyltransferase (aacA4), ribosome methyltransferase (rmtC), fluoroquinolone efflux pumps (oqxA, oqxB), and sulfonamide resistance gene (sul1).
Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing.
The paper discusses the prevalence of antimicrobial resistance in Aeromonas species, highlighting the presence of various beta-lactamase genes such as blaTEM-24, blaIMP-19, blaVIM-4, blaKPC-2, blaNDM-1, blaVIM-2, blaOXA-48, blaIMP-13, blaGES-5, blaTEM-1, blaSHV-12, blaVEB-9, blaMOX, blaFOX, blaACC, and others. It also identifies genes like cphA, vat, mcr-3.41, mcr-7.1, sul, dfr, tetA, rsmA, and adeF associated with resistance to sulfonamides, trimethoprim, tetracycline, polymyxin, and other antibiotics. The study emphasizes the role of horizontal gene transfer and mobile genetic elements in the dissemination of these resistance genes.
Interspecific competition prevents the proliferation of social cheaters in an unstructured environment.
The study identifies the sul1 gene as a sulfamethoxazole resistance gene in Pseudomonas aeruginosa, demonstrating its role in conferring resistance through plasmid transduction.
Inter-plasmid transfer of antibiotic resistance genes accelerates antibiotic resistance in bacterial pathogens.
The study identifies numerous antibiotic resistance genes (ARGs) that are transferred between plasmids, particularly beta-lactamases (bla TEM-1, bla NDM-4, bla KPC-2, bla SHV-1), aminoglycoside resistance gene aacC1, and colistin resistance gene mcr-1. These genes are shown to transfer between compatible plasmids in clinical pathogens, accelerating the spread of antibiotic resistance.
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
The study identified various antimicrobial resistance genes and mutations in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain, highlighting the presence of multidrug-resistant strains and the role of plasmids in the dissemination of resistance mechanisms.
Emergence of multidrug-resistant Bacillus spp. derived from animal feed, food and human diarrhea in South-Eastern Bangladesh.
The study identifies multiple AMR genes in Bacillus spp. isolated from animal feed, food, and human diarrhea in Bangladesh, highlighting the prevalence of multidrug resistance and the need for monitoring in the agricultural and food sectors.
Genetic Diversity of Salmonella enterica subsp. enterica Serovar Enteritidis from Human and Non-Human Sources in Portugal.
The study identified several AMR genes and mutations in Salmonella enterica subsp. enterica serovar Enteritidis isolates from human and non-human sources in Portugal, including blaTEM-1A, blaTEM-1B, blaCMY-2, aac(6')-Iaa, sul1, and aaDA1, as well as mutations in gyrA associated with fluoroquinolone resistance.
Genomic Surveillance Uncovers a 10-Year Persistence of an OXA-24/40 Acinetobacter baumannii Clone in a Tertiary Hospital in Northern Spain.
The study identifies the persistence of an OXA-24/40 Acinetobacter baumannii clone over 10 years in a Spanish hospital, highlighting the role of the bla OXA-24/40 gene and a novel variant, bla OXA-1040, in carbapenem resistance. It also characterizes other resistance genes such as aad A1, aph (3')-VIa-like, str A, str B, sul1, sul2, and tet(B)-like, contributing to multidrug resistance.
Genomic Features and Phylogenetic Analysis of Antimicrobial-Resistant Salmonella Mbandaka ST413 Strains.
The study identified nine resistance genes, including aac(6')-Iaa, sul1, qacE, blaOXA-129, tet(B), and aadA1, as well as a point mutation in ParC (T57S) associated with quinolone resistance in Salmonella Mbandaka ST413 strains.
In-depth characterization of multidrug-resistant NDM-1 and KPC-3 co-producing Klebsiella pneumoniae bloodstream isolates from Italian hospital patients.
The study characterized multidrug-resistant NDM-1 and KPC-3 co-producing Klebsiella pneumoniae bloodstream isolates, identifying several AMR genes and mutations associated with resistance to various antibiotics.
Isolation, Identification, Antimicrobial Resistance, Genotyping, and Whole-Genome Sequencing Analysis of Salmonella Enteritidis Isolated from a Food-Poisoning Incident.
The study identified multiple antimicrobial resistance genes in Salmonella Enteritidis strain 21A, including aac(6')-Iaa, blaTEM-1, qnrB, floR, tetA, sul1, and sul2, which conferred resistance to various antibiotics such as aminoglycosides, beta-lactams, quinolones, tetracyclines, and sulfonamides.
Genomic analysis of clinical Aeromonas isolates reveals genetic diversity but little evidence of genetic determinants for diarrhoeal disease.
The study identifies a high prevalence of antimicrobial resistance (AMR) genes in Aeromonas isolates from children with moderate-to-severe diarrhea (MSD) in Karachi, Pakistan. Key AMR genes include beta-lactamases (blaCMY-1, oxa-12, cphA2, mox), sulfonamide resistance (sul1), aminoglycoside resistance (aac(6')-lld), and tetracycline resistance (tetE).
Phenotypic, molecular detection, and Antibiotic Resistance Profile (MDR and XDR) of Aeromonas hydrophila isolated from Farmed Tilapia zillii and Mugil cephalus.
The study identified several AMR genes in Aeromonas hydrophila isolates from farmed fish, including bla_pse1, bla_SHV, tetA, and sul1, which confer resistance to beta-lactams, tetracyclines, and sulfonamides.
Outbreak of NDM-5-producing Klebsiella pneumoniae ST307: an emerging high-risk antimicrobial resistance clone in Shanghai, China.
The study reports an outbreak of NDM-5-producing Klebsiella pneumoniae ST307 in Shanghai, China, highlighting the presence of multiple resistance genes including bla NDM-5, bla CTX-M-15, and bla DHA-1, which confer resistance to carbapenems, cephalosporins, and other antibiotics.
Characterization of the diversity of type IV secretion system-encoding plasmids in Acinetobacter.
The study characterizes the diversity of T4SS-encoding plasmids in Acinetobacter, identifying various antibiotic resistance genes such as blaOXA-23, blaOXA-82, blaGES-11, aph(3')-VIa, aadA2, sul1, dfrA7, cmlA1, and qacEΔ1, highlighting their role in multidrug resistance.
Horizontal transfer characterization of ColV plasmids in bla(CTX-M)-bearing avian Escherichia coli.
The study characterizes the horizontal transfer of ColV plasmids in bla(CTX-M)-bearing avian E. coli, identifying multiple resistance genes and virulence factors associated with these plasmids.
Activity of Epsilon-poly-L-lysine against Multidrug-Resistant Pseudomonas aeruginosa and Klebsiella pneumoniae Isolates of Urinary Tract Infections.
The study identified various beta-lactamase genes, including blaSPM, blaKPC, blaSHV, blaCTX-M, blaOXA, blaTEM, blaPER, blaVIM, and blaVIM-2 in Pseudomonas aeruginosa, and blaCTX-M, blaTEM, blaKPC, blaNDM, and blaOXA in Klebsiella pneumoniae. Additionally, aac(3)-IV, aadA1, aac(3)-II, sul2, sul1, sul3, dfrA, cmlA, and tetA were found to confer resistance to aminoglycosides, sulfonamides, trimethoprim, chloramphenicol, and tetracyclines.
Molecular characterization of Aeromonas hydrophila detected in Channa marulius and Sperata sarwari sampled from rivers of Punjab in Pakistan.
The study identified several AMR genes in Aeromonas hydrophila isolates from fish samples, including tetA, blaTEM, qnrA, qnrB, sul1, and sul3, indicating multidrug resistance.
Antibiotic susceptibility and resistance genes profiles of Vagococcus salmoninarum in a rainbow trout (Oncorhyncus mykiss, Walbaum) farm.
The study identified several antibiotic resistance genes in Vagococcus salmoninarum isolates from a rainbow trout farm, including tetA, sul1, sul2, sul3, dhfr1, ereB, and floR, which confer resistance to tetracycline, sulfonamides, trimethoprim/sulfamethoxazole, erythromycin, lincomycin, pristinamycin, tylosin, and florfenicol.
Comparison of genotypic and phenotypic antimicrobial resistance profiles of Salmonella enterica isolates from poultry diagnostic specimens.
The study identified 31 AMR genes in 97 Salmonella enterica isolates from poultry, including aac(3)-IId, aac(3)-IVa, aac(3)-VIa, aac(6′)-Ib4, ant(2′′)-Ia, grdA, aph(3′)-Ia, aph(3′)-IIa, aadA1, aadA2, aadA7, aadA13, aph(3′)-Ib, aph(6)-Ic, aph(6)-Id, aph(4)-Ia, blaCMY-2, blaCTX-M-1, blaHER-3, blaTEM-1, floR, tetA, tetB, tetC, dfrA12, sul1, sul2, fosA7, qnrB19, ble, and mcr-9.
Antimicrobial resistance of avian pathogenic Escherichia coli isolated from broiler, layer, and breeder chickens.
The study identified multiple antibiotic resistance genes in avian pathogenic Escherichia coli (APEC) isolates from commercial chickens in Nepal, including blaTEM, sul1, qnrA, tetB, cat1, ereA, mcr1, and aac(3)-IV, which confer resistance to various antimicrobial agents.
Klebsiella pneumoniae exhibiting a phenotypic hyper-splitting phenomenon including the formation of small colony variants.
The study identifies multiple beta-lactamase genes, including bla SHV-11, bla OXA-1, bla OXA-9, bla OXA-48, bla TEM-1D, bla CTX-M-15, and bla NDM-1, as well as sul1 and catB3, which confer resistance to various antibiotics in Klebsiella pneumoniae isolates from a patient with a complex infection history.
Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease.
The study characterizes three ciprofloxacin-resistant and extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198 strains from a single patient with inflammatory bowel disease, highlighting their multidrug-resistant profile and potential epidemiological links to strains from chicken meat.
Klebsiella pneumoniae sequence type 147: a high-risk clone increasingly associated with plasmids carrying both resistance and virulence elements.
The study identified various AMR genes and mutations in Klebsiella pneumoniae ST147 isolates, including bla NDM-5, bla NDM-1, bla OXA-181, bla OXA-232, bla OXA-48, aadA1, aph(3')-VI, bla CTX-M-15, bla TEM-1B/C, bla OXA-9, truncated catA1, qnrS1, sul1, dfrA5, mph(A), erm(B), aac(6')-Ib, aac(6')-Ib3, sul2, aph(3')-Ia, rmtB, fosA, oqxAB, bla SHV-11/67, arr-3, and catB3.
Predominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar.
The study identifies multidrug-resistant Salmonella Typhi genotype 4.3.1.1 with low-level ciprofloxacin resistance in Zanzibar, highlighting the presence of resistance genes blaTEM-1B, sul1, sul2, dfrA7, catA1, aph(6)-Id, and aph(3")-Ib, along with gyrA mutations D87G and S83F.
A review of the mechanisms that confer antibiotic resistance in pathotypes of E. coli.
The review discusses the mechanisms of antibiotic resistance in pathotypes of E. coli, focusing on the role of beta-lactamases, carbapenemases, and other resistance genes. It highlights the importance of understanding these mechanisms to combat the growing problem of antibiotic resistance.
Exploring the resistome, virulome, and mobilome of multidrug-resistant Klebsiella pneumoniae isolates: deciphering the molecular basis of carbapenem resistance.
The study identifies multiple antibiotic resistance genes, including bla CTX-M-15, bla TEM, bla SHV, bla NDM, bla OXA, and others, contributing to carbapenem resistance in Klebsiella pneumoniae isolates. Mutations in porin genes ompK35 and ompK36, as well as in gyrA and parC, are associated with reduced susceptibility to carbapenems and fluoroquinolones.
Heterogeneous Antibiotic Resistance Gene Removal Impedes Evaluation of Constructed Wetlands for Effective Greywater Treatment.
The study identifies several antibiotic resistance genes (ARGs) in greywater and filter bed samples, including blaTEM, sul1, intI1, tetG, tetW, and others, indicating the presence of resistance to beta-lactams, sulfonamides, tetracyclines, and other antibiotics. The research highlights the variability in ARG removal efficiency by constructed wetlands and the potential for ARG proliferation in treated greywater.
Comparison of IncK-bla(CMY-2) Plasmids in Extended-Spectrum Cephalosporin-Resistant Escherichia coli Isolated from Poultry and Humans in Denmark, Finland, and Germany.
The study characterizes IncK-bla(CMY-2) plasmids in extended-spectrum cephalosporin-resistant E. coli isolates from poultry and humans in Denmark, Finland, and Germany, identifying multiple resistance genes including bla(CMY-2), aadA1, aac(3)-Vla, aph(3")-Ib, aph(6)-Id, aac(3)-IId, aadA5, aph(3′)-Ia, sul1, sul2, tet(A), tet(B), and bla TEM-1B.
Resistome Analysis of Klebsiella pneumoniae Complex from Residential Aged Care Facilities Demonstrates Intra-facility Clonal Spread of Multidrug-Resistant Isolates.
The study identified several AMR genes and mutations in K. pneumoniae isolates from RACFs, including beta-lactamases (bla DHA-1, bla SHV-1, bla SHV-27, bla CTX-M-14), fluoroquinolone resistance determinant qnrB4, and trimethoprim-sulfamethoxazole resistance determinants dfrA17 and sul1. Mutations in ompK35, ompK37, prmA, pmrB, eptA, and parC were also found to contribute to resistance.
Tracking antimicrobial resistance transmission in urban and rural communities in Bangladesh: a One Health study of genomic diversity of ESBL-producing and carbapenem-resistant Escherichia coli.
The study identified various beta-lactamase genes, including bla CTX-M-15, bla TEM-1b, bla OXA-1, and carbapenem resistance genes like bla NDM-5, bla NDM-7, and bla NDM-1, in ESBL-producing and carbapenem-resistant E. coli isolates from Bangladesh.
Characterization of Escherichia coli pathogenicity and drug resistance in yolk peritonitis.
The study identified multiple drug resistance genes in E. coli isolates from yolk peritonitis cases, including aadA5, APH(3")-Ib, APH(6)-Id, TEM-1, sul1, sul2, parC, gyrA, mfd, kdpE, mphA, and Mrx, which confer resistance to aminoglycosides, beta-lactams, sulfonamides, and fluoroquinolones.
Generation and maintenance of the circularized multimeric IS26-associated translocatable unit encoding multidrug resistance.
The study identifies the amplification of the P2 region containing multiple AMR genes, including bla CTX-M-14, tet(A), drfA, and sul1, in Klebsiella pneumoniae isolates under antimicrobial selection pressure.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
The study identifies multiple AMR genes and mutations in multidrug-resistant E. coli strains causing infections in dogs and cats, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla CMY-2, bla CMY-148, aac(6')-Ib-cr, qnrS1, qnrB6, aadA2, aadA5, aadA16, ant(3′′)-Ia, aph(3′)-Ia, aph(3′′)-Ib, aph(6)-Id, rmtB, floR, cmlA, catA, sul1, sul2, sul3, dfrA12, dfrA14, dfr17, dfrA27, tet(A), tet(B), tet(M), mph(A), erm(B), lnu(F), and arr-3, as well as the gyrA:p.S83L mutation.
Unveiling the genetic architecture and transmission dynamics of a novel multidrug-resistant plasmid harboring bla(NDM-5) in E. Coli ST167: implications for antibiotic resistance management.
The study identifies a novel multidrug-resistant plasmid pNDM-5-0083 carrying bla NDM-5, bla TEM-1B, aadA2, rmtB, dfrA12, and sul1, which contributes to resistance against multiple antibiotics in E. coli ST167.
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications.
The study identified several AMR genes in multidrug-resistant E. coli isolates from urban environmental water sources in Accra, Ghana, highlighting the presence of beta-lactamases (blaTEM-1B, blaCTX-M-15, blaTEM-1C, blaDHA-1, blaOXA-1, blaOXA-181), sulfonamide resistance genes (sul2, sul1), aminoglycoside resistance genes (aph(6)-Id, aadA2, mph(A)), quinolone resistance gene (qnrS1), tetracycline resistance gene (tet(B)), chloramphenicol resistance gene (catA1), dihydrofolate reductase (dfrA14), and others.
Occurrence, molecular characterization, and antimicrobial susceptibility of sorbitol non-fermenting Escherichia coli in lake water, fish and humans in central Oromia, Ethiopia.
The study identified multiple antimicrobial resistance genes in sorbitol non-fermenting E. coli strains, including blaTEM-1B, tet(A), dfrA1, dfrA5, sul1, fos7, catA1, qnrS1, gyrA, and blaCTX-M15, which conferred resistance to various antibiotics such as ampicillin, tetracycline, trimethoprim, sulfamethoxazole, fosfomycin, chloramphenicol, ciprofloxacin, nalidixic acid, and extended-spectrum beta-lactams.
Occurrence and genomic characterization of antimicrobial-resistant and potential pathogenic Escherichia coli from Italian artisanal food productions of animal origin.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia coli isolates from Italian artisanal food products, including beta-lactamases, aminoglycoside-modifying enzymes, trimethoprim resistance genes, macrolide resistance genes, quinolone resistance proteins, sulfonamide resistance proteins, and tetracycline resistance genes. These genes were primarily carried on plasmids and contributed to multidrug resistance.
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
The study identified several carbapenem-resistant genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla OXA-50, bla OXA-395, bla NDM-7, and bla NDM-5, in various bacterial species in Fiji.
Genomic characterisation of Escherichia coli isolated from poultry at retail through Sink Surveillance in Dhaka, Bangladesh reveals high levels of multi-drug resistance.
The study identified multiple AMR genes in E. coli isolates from poultry in Bangladesh, including genes conferring resistance to various antibiotics such as tetracycline, ciprofloxacin, azithromycin, colistin, and others. High levels of multidrug resistance were observed, with specific genes like mcr1.1, bla CTX-M-65, and tet(A) playing significant roles.
Salmonella Typhi Haplotype 58 (H58) Biofilm Formation and Genetic Variation in Typhoid Fever Patients with Gallstones in an Endemic Setting in Kenya.
The study identified multidrug resistance genes such as sul1, dfrA7, catA1, aph(6)-Id, aph(3")-Ib, sul2, and blaTEM-1 in S. Typhi isolates from patients with gallstones. Additionally, point mutations in the quinolone resistance determining region (QRDR) of gyrA (S83Y) and gyrB (S464F) were observed, contributing to resistance against ciprofloxacin and nalidixic acid.
A panel of genotypically and phenotypically diverse clinical Acinetobacter baumannii strains for novel antibiotic development.
The study identifies various AMR genes and mutations in a diverse panel of Acinetobacter baumannii strains, including bla OXA-23, bla OXA-24, bla OXA-58, bla NDM-1, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Four novel Acinetobacter lwoffii strains isolated from the milk of cows in China with subclinical mastitis.
Four Acinetobacter lwoffii strains were isolated from the milk of cows with subclinical mastitis in China. These strains exhibited multidrug resistance and carried 17 resistance genes, including beta-lactamase, aminoglycoside-modifying, fluoroquinolone, tetracycline, sulfonamide, and chloramphenicol resistance genes.
Selection and horizontal gene transfer underlie microdiversity-level heterogeneity in resistance gene fate during wastewater treatment.
The study identifies several resistance genes, including mphA, msrE, tet(39), sul1, sul2, mer, qac, and aadA, which were found to be associated with hospital sewage and showed variations in their persistence in activated sludge. These genes contribute to resistance against macrolides, tetracyclines, sulfonamides, mercury, quaternary ammonium compounds, and aminoglycosides.
Whole-Genome Analysis of Extensively Drug-Resistant Enterobacter hormaechei Isolated from a Patient with Non-Hodgkin's Lymphoma.
The study identifies an extensively drug-resistant Enterobacter hormaechei ST90 clone carrying multiple resistance genes, including bla CTX-M-15, bla GES-2, bla TEM-1A, bla OXA-1, bla NDM-1, and bla ACT-15, along with genes encoding resistance to aminoglycosides, quinolones, sulfonamides, chloramphenicol, fosfomycin, and other antibiotics.
Metagenomic Investigation of the Short-Term Temporal and Spatial Dynamics of the Bacterial Microbiome and the Resistome Downstream of a Wastewater Treatment Plant in the Iskar River in Bulgaria.
The study identified various antimicrobial resistance genes (ARGs) in the Iskar River downstream of a wastewater treatment plant (WWTP), including genes conferring resistance to macrolides, tetracyclines, beta-lactams, sulfonamides, and carbapenems. Notably, the carbapenemase genes bla OXA-58 and bla IMP-33-like were detected, which are typically associated with clinical settings.
Prevalence of multidrug-resistant Escherichia coli isolates and virulence gene expression in poultry farms in Jos, Nigeria.
The study identified multidrug-resistant Escherichia coli isolates in poultry farms in Jos, Nigeria, with resistance genes including tetA, gyrA, sul1, and ampC.
The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi.
The study identifies multiple antimicrobial resistance (AMR) genes and mutations in Salmonella Typhi H58 lineage, highlighting its multidrug resistance and the role of IncH1 plasmids in conferring resistance to various antibiotics.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
Pathogenomics analysis of high-risk clone ST147 multidrug-resistant Klebsiella pneumoniae isolated from a patient in Egypt.
The study identifies multiple AMR genes in the MDR-KP isolate WSF99, including various beta-lactamases, carbapenemase, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and others, highlighting the complex resistance profile of this high-risk clone.
Comprehensive genomics reveals novel sequence types of multidrug resistant Klebsiella oxytoca with uncharacterized capsular polysaccharide K- and lipopolysaccharide O-antigen loci from the National Hospital of Uganda.
The study identified multiple AMR genes in multidrug-resistant Klebsiella oxytoca isolates, including beta-lactamases (blaOXY-2–6, blaOXY-2–8), quinolone resistance gene qnrS1, tetracycline resistance gene tet(A).v1, sulfonamide resistance gene sul1^, and trimethoprim resistance genes dfrA14.v2* and dfrA15.v2.
The IncC and IncX1 resistance plasmids present in multi-drug resistant Escherichia coli strains isolated from poultry manure in Poland.
The study identifies three resistance plasmids (pECmdr13.2, pECmdr13.3, pECmdr14.1) in multi-drug resistant E. coli strains from poultry manure in Poland, each carrying various AMR genes including tetracycline, aminoglycoside, beta-lactam, sulfonamide, fluoroquinolone, and phenicol resistance genes.
Genomic analysis of carbapenem- and colistin-resistant Klebsiella pneumoniae complex harbouring mcr-8 and mcr-9 from individuals in Thailand.
The study identifies mcr-8 and mcr-9 genes in carbapenem-resistant Klebsiella pneumoniae complex isolates from Thailand, highlighting their role in colistin resistance. It also characterizes additional AMR genes such as bla NDM-1, bla IMP-14, and various other resistance determinants.
Salmonella Typhi genotypic diversity, cluster identification and antimicrobial resistance determinants in Mukuru settlement, Nairobi Kenya.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella Typhi isolates from Mukuru settlement, Nairobi, Kenya, highlighting the prevalence of multidrug-resistant strains.
Molecular Characterization and Antibacterial Resistance Determination of Escherichia coli Isolated from Fresh Raw Mussels and Ready-to-Eat Stuffed Mussels: A Major Public Health Concern.
The study identified several AMR genes in E. coli isolates from mussels, including tetB, sul1, sul2, floR, qnrA, and qnrB, which confer resistance to tetracycline, sulfonamides, chloramphenicol, and fluoroquinolones.
Mobile genetic elements define the non-random structure of the Salmonella enterica serovar Typhi pangenome.
The study identifies multiple AMR genes, including blaTEM-1B, qnrS1, sul2, tet(A), aph(3'')-Ib, aph(6)-Id, dfrA14, blaCTX-M-15, blaCTX-M-88, catA1, qacE, sul1, and tet(B), which are associated with multidrug-resistant and extensively drug-resistant Salmonella enterica serovar Typhi strains.
Host species shapes genotype, antimicrobial resistance, and virulence profiles of enterotoxigenic Escherichia coli (ETEC) from livestock in the United States.
The study identifies distinct antimicrobial resistance (AMR) gene profiles in bovine and swine enterotoxigenic Escherichia coli (ETEC) isolates, highlighting differences in the prevalence of specific AMR genes and plasmid replicons between the two host species.
Multi-drug resistant (MDR) Gram-negative pathogenic bacteria isolated from poultry in the Noakhali region of Bangladesh.
The study identified multiple AMR genes, including blaTEM, blaSHV, tetA, tetB, sul1, sul2, and mcr-1, in various multidrug-resistant Gram-negative bacteria isolated from poultry in Bangladesh. These genes conferred resistance to a wide range of antibiotics, highlighting the significant public health concerns associated with AMR in poultry.
Metagenome-wide characterization of shared antimicrobial resistance genes in sympatric people and lemurs in rural Madagascar.
The study identified five tetracycline resistance genes (tet(32), tet(40), tet(W), tet(Q)) and one trimethoprim resistance gene (dfrF) that were significantly more abundant in human microbiomes compared to lemur microbiomes. These genes were found to be highly conserved between human and lemur microbiomes.
Phylogenetic group, antibiotic resistance, virulence gene, and genetic diversity of Escherichia coli causing bloodstream infections in Iran.
The study identified several AMR genes, including bla TEM, sul1, sul2, bla CTX-M, and bla OXA, in E. coli isolates causing bloodstream infections in Iran. These genes were associated with resistance to multiple antibiotics, highlighting the prevalence of multidrug-resistant strains.
Tracing the origin of NDM-1-producing and extensively drug-resistant Pseudomonas aeruginosa ST357 in the Netherlands.
The study identifies the NDM-1-producing Pseudomonas aeruginosa ST357 as an extensively drug-resistant strain with a unique resistome, highlighting the importance of tracking the origin of such isolates through genomic epidemiology.
Antimicrobial resistance profiles and genome characteristics of Klebsiella isolated from the faeces of neonates in the neonatal intensive care unit.
The study identified multiple antimicrobial resistance genes in Klebsiella isolates from neonates in the NICU, including bla NDM-1, bla CTX-M-15, bla SHV-67, aac(6')-Ib-cr, aadA16, aph(3'')-Ib, and others. These genes confer resistance to various antibiotics such as carbapenems, cephalosporins, aminoglycosides, and fluoroquinolones. Additionally, the study found a multidrug-resistant Klebsiella pneumoniae strain carrying several resistance genes and plasmids.
Bacterial Genomics for National Antimicrobial Resistance Surveillance in Cambodia.
The study identified various AMR genes and mutations in bacterial isolates from Cambodia, including extended-spectrum beta-lactamase genes (blaCTX-M-15, blaCTX-M-27, blaCTX-M-55), carbapenemase genes (blaOXA-23, blaNDM-1, blaOXA-58, blaOXA-66), and colistin resistance genes (mcr-1, mcr-3, mcr-7, mcr-9). Additionally, mutations in gyrA (S83F) and parC (S84L) were found to confer fluoroquinolone resistance in Salmonella enterica serovars Paratyphi A and Typhi.
Resolved genomes of wastewater ESBL-producing Escherichia coli and metagenomic analysis of source wastewater samples.
The study identified several beta-lactam resistance genes, including bla CTX-M-55, bla TEM-1, and bla SHV-2A, along with aminoglycoside, tetracycline, and sulfonamide resistance genes in ESBL-producing E. coli isolates from wastewater samples.
IncC plasmid genome rearrangements influence the vertical and horizontal transmission tradeoff in Escherichia coli.
The study identifies blaCTX-M-14 and blaCTX-M-15 as beta-lactamase genes, aacC2, aph, and sul2 as aminoglycoside and sulfonamide resistance genes, and shows that plasmid rearrangements enhance conjugation efficiency without affecting vertical transmission.
Infection by a multidrug-resistant Corynebacterium diphtheriae strain: prediction of virulence factors, CRISPR-Cas system analysis, and structural implications of mutations conferring rifampin resistance.
Carriage Rate of Enterobacterales Resistant to Extended-Spectrum Cephalosporins in the Tunisian Population.
The study identified bla CTX-M-15 and bla DHA-1 as the primary genes conferring resistance to extended-spectrum cephalosporins in Enterobacterales isolated from healthy Tunisian individuals. Additional resistance mechanisms included aminoglycoside, sulfonamide, tetracycline, and quinolone resistance genes.
An in-depth study on survival mechanism of bacterial isolates in disinfectants within the hospital environment.
The study identified multiple AMR genes, including blaDIM-1, qacE, and various efflux pump genes, in bacterial isolates from hospital disinfectants, indicating their adaptation to survive in disinfectant environments.
An in-depth study on survival mechanism of bacterial isolates in disinfectants within the hospital environment.
The study identified multiple AMR genes, including blaDIM-1, qacE, and various efflux pump genes, in bacterial isolates from hospital disinfectants, indicating their adaptation to survive in disinfectant environments.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
High Carriage of tetA, sul1, sul2 and bla (TEM) Resistance Genes among the Multidrug-resistant Uropathogenic Escherichia coli (UPEC) Strains from Malaysian Patients.
The study identified the high prevalence of tetA, sul1, sul2, and bla TEM resistance genes among multidrug-resistant Uropathogenic Escherichia coli (UPEC) strains in Malaysia.
Characterization of the carbapenem-resistant Acinetobacter baumannii clinical reference isolate BAL062 (CC2:KL58:OCL1): resistance properties and capsular polysaccharide structure.
The study characterizes the carbapenem-resistant Acinetobacter baumannii isolate BAL062, identifying resistance genes such as oxa23, ampC, strA-strB, tet(B), sul1, aadA1, and aacC1. It also reveals that BAL062 has lost certain resistance genes, resulting in susceptibility to amikacin, tobramycin, and kanamycin.
Antibiotic Resistance Genes and Plasmid Characteristics in Enterobacteriaceae Isolated from Fresh Produce
The study identified several antibiotic resistance genes on plasmids and chromosomes of Enterobacteriaceae strains isolated from fresh produce, highlighting the diversity of resistance mechanisms and the potential for horizontal gene transfer.
Extended-spectrum beta-lactamase (ESBL)- and non-ESBL producing Escherichia coli surveillance in surface water sources in Edo State, Nigeria: a public health concern.
The study identified ESBL genes bla TEM, bla CTX-M-1, and bla CTX-M-15, as well as resistance genes tetM, sul1, sul2, and qnrA in ESBL and non-ESBL-producing E. coli isolates from surface water in Edo State, Nigeria.
Genomic Characteristics of a Carbapenem-Resistant Klebsiella pneumoniae Co-Carrying bla (NDM-5) and bla (KPC-2) Capsular Type KL25 Recovered from a County Level Hospital in China.
The study reports the genomic characteristics of a multidrug-resistant ST11 Klebsiella pneumoniae isolate SM117 with capsular serotype KL25, co-carrying bla NDM-5, two copies of bla KPC-2, and multiple plasmid-borne virulence genes. The isolate shows resistance to all antibiotics except polymyxin.
Whole-genome sequencing of two multidrug-resistant acinetobacter baumannii strains isolated from a neonatal intensive care unit in Egypt: a prospective cross-sectional study.
The study identified multidrug-resistant Acinetobacter baumannii strains from a neonatal ICU in Egypt, highlighting the presence of various beta-lactamase genes, aminoglycoside resistance genes, macrolide resistance genes, tetracycline resistance genes, and sulfonamide resistance genes.
Genomic Characterization of Extended-Spectrum β-Lactamase-Producing and Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from Stools of Primary Healthcare Patients in Ethiopia.
The study identified multiple antimicrobial resistance genes in E. coli isolates, including bla CTX-M-15, bla TEM-1B, tet(A), qnrS1, and others, highlighting the prevalence of multidrug resistance in the region.
Genomic Insights into Vietnamese Extended-Spectrum β-Lactamase-9-Producing Extensively Drug-Resistant Pseudomonas aeruginosa Isolates Belonging to the High-Risk Clone ST357 Obtained from Bulgarian Intensive Care Unit Patients.
The study identified multiple AMR genes, including blaVEB-9, blaPDC-3, blaOXA-10, blaOXA-50, and others, in two extensively drug-resistant Pseudomonas aeruginosa isolates from Bulgaria. These genes conferred resistance to various antibiotics, including β-lactams, aminoglycosides, and fluoroquinolones.
Comprehensive Genomic Analysis of Uropathogenic E. coli: Virulence Factors, Antimicrobial Resistance, and Mobile Genetic Elements.
The study identified numerous antimicrobial resistance genes and mutations in uropathogenic E. coli isolates, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and quinolone resistance genes. Mutations in gyrA, parC, parE, and marR were associated with fluoroquinolone resistance, while mutations in PmrB, CyaA, GlpT, PtsI, and UhpT were linked to fosfomycin resistance.
Investigation on the mechanisms of carbapenem resistance among the non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae.
The study identified non-carbapenemase β-lactamase genes and chromosomal mutations, including missense mutation or loss of ompK36 porin and frameshift missense mutation in efflux pump systems, as potential mechanisms of carbapenem resistance in NC-CRKP.
First report of carbapenems encoding multidrug-resistant gram-negative bacteria from a pediatric hospital in Gaza Strip, Palestine.
The study identified multiple carbapenem resistance genes, including bla KPC-2, bla PDC-36/12, and bla POM-1, in multidrug-resistant Gram-negative bacteria isolated from a pediatric hospital in the Gaza Strip. These genes were found in various bacterial species such as Escherichia coli and Klebsiella pneumoniae.
Molecular epidemiological analysis of bla(NDM-5)-producing Klebsiella pneumoniae ST2407-K25 causing infection outbreaks in pediatric patients based on whole genome sequencing.
The study identifies bla_NDM-5 as the primary carbapenem resistance gene in CRKP ST2407-K25 isolates, along with additional resistance genes such as bla_DHA-1, bla_SHV-1, bla_CTX-M-14, qnrB4, sul1, and qacEΔ1. Mutations in ramR and acrR are linked to tigecycline resistance.
Contribution of the Mobilome to the Configuration of the Resistome of Corynebacterium striatum.
The study identified 20 antimicrobial resistance genes in Corynebacterium striatum, with ErmX being the most prevalent. These genes are mainly associated with plasmid sequence regions and class 1 integrons, highlighting the role of mobile genetic elements in the dissemination of resistance.
Role of migratory birds as a risk factor for the transmission of multidrug resistant Salmonella enterica and Escherichia coli to broiler poultry farms and its surrounding environment.
The study identified several AMR genes, including Sul1, Tet A (A), bla TEM, ere A, and qnrA, in multidrug-resistant Salmonella enterica and Escherichia coli isolated from migratory birds and broiler poultry farms.
Analyzing Antibiotic Resistance in Bacteria from Wastewater in Pakistan Using Whole-Genome Sequencing.
The study identifies several AMR genes and mutations in wastewater isolates from Pakistan, highlighting the presence of carbapenemases like blaNDM-5 and blaOXA-1, as well as quinolone resistance determinants such as gyrA and parC mutations. These findings emphasize the role of wastewater as a reservoir for clinically relevant AMR genes.
Genomic Characterization of 16S rRNA Methyltransferase-Producing Enterobacterales Reveals the Emergence of Klebsiella pneumoniae ST6260 Harboring rmtF, rmtB, bla(NDM-5), bla(OXA-232) and bla(SFO-1) Genes in a Cancer Hospital in Bulgaria.
The study identifies the emergence of Klebsiella pneumoniae ST6260 harboring multiple AMR genes, including rmtF, rmtB, bla(NDM-5), bla(OXA-232), and bla(SFO-1), highlighting the complexity of resistance mechanisms in Enterobacterales.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Characterization of Extraintestinal Pathogenic Escherichia coli Strains Causing Canine Pneumonia in China: Antibiotic Resistance, Virulence Genes, and Sequence Typing.
Four multidrug-resistant strains of extraintestinal pathogenic Escherichia coli (ExPEC) were identified in puppies with acute pneumonia, carrying resistance genes such as TEM, CTX-M-55, mec, tet, AAC-IId, cmlA, dfrA, and sul. These strains were classified as ST131 or ST43 and showed resistance to cephalosporins, tetracyclines, and penicillins, but were susceptible to aminoglycosides, beta-lactamase inhibitors, carbapenems, chloramphenicols, and sulfonamides.
Natural compound-induced downregulation of antimicrobial resistance and biofilm-linked genes in wastewater Aeromonas species.
The study identifies aadA1, aadA2, and sul1 as antimicrobial resistance genes in wastewater Aeromonas species, which are downregulated by natural compounds.
Analysis of Acinetobacter P-type type IV secretion system-encoding plasmid diversity uncovers extensive secretion system conservation and diverse antibiotic resistance determinants.
This study identified 17 distinct antibiotic resistance genes across 53 P-type T4SS-encoding plasmids in Acinetobacter species, including various beta-lactamases, aminoglycoside modifying enzymes, and others, highlighting the significant diversity of resistance determinants carried by these plasmids.
Virulence and Antimicrobial Resistance Patterns of Salmonella spp. Recovered From Migratory and Captive Wild Birds.
The study identified the presence of AMR genes blaTEM, blaSHV, sul1, and tet(A) in Salmonella spp. recovered from migratory and captive wild birds, highlighting the potential for these birds to act as reservoirs of multidrug-resistant bacteria.
Combatting extensively drug-resistant Salmonella: a global perspective on outbreaks, impacts, and control strategies.
The paper discusses the emergence and global spread of extensively drug-resistant (XDR) Salmonella, highlighting the resistance mechanisms involving genes such as blaCTX-M-15, floR, cat1, cat2, strA, strB, aacC(3), aadA, ant(3")-Ia, aph(3)-IIa, tet(A), tet(B), tet(D), tet(G), tet(H), dfrA10, dhfrXII, sul1, sul2, sul3, mphA, and ermB.
Antimicrobial Resistance in Wastewater Samples from Kumasi, Ghana: A Genomic and Metagenomic Analysis
The study identified several AMR genes and mutations in P. aeruginosa and K. pneumoniae isolates from wastewater samples in Kumasi, Ghana, highlighting the presence of multidrug-resistant strains carrying genes such as blaCTX-M-15, blaOXA-488, and qnrVC1, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Limited Evidence of Spillover of Antimicrobial-Resistant Klebsiella pneumoniae from Animal/Environmental Reservoirs to Humans in Vellore, India.
The study found that clinical and hospital sewage isolates of Klebsiella pneumoniae had a higher number of AMR genes compared to livestock isolates, suggesting that AMR is more prevalent in human-associated settings. Several beta-lactamase genes, including blaCTX-M, blaNDM, blaKPC, and blaOXA-48, were detected in clinical isolates, contributing to resistance against carbapenems and other antibiotics. Other AMR genes such as qnrS1, aac(6')-Ib, aadA, ermB, mefA, tet(A), mph(A), cat, cfr, vanA, mcr-1, fosA, sul1, and dfrA1 were also identified, highlighting the diversity of resistance mechanisms in K. pneumoniae.
Neural network-based predictions of antimicrobial resistance phenotypes in multidrug-resistant Acinetobacter baumannii from whole genome sequencing and gene expression.
The study presents a deep neural network model capable of predicting antimicrobial resistance phenotypes in multidrug-resistant Acinetobacter baumannii using whole genome sequencing and gene expression data. The model achieves high accuracy in predicting resistance to various antibiotics, including β-lactams, aminoglycosides, and carbapenems.
Effects of sulfamethoxazole and copper on the natural microbial community from a fertilized soil.
The study identified the presence of sul1 and sul2 genes in the soil microbial community, which confer resistance to sulfamethoxazole. The presence of copper was found to increase the persistence of these resistance genes.
Genomic characterisation of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate assigned to a novel sequence type (6914).
The study reports the genomic characterization of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate, Cow102, which exhibits multidrug resistance. It identifies several resistance genes, including blaSHV-1, blaSHV-11, blaSHV-13, blaSHV-26, blaSHV-70, blaSHV-78, blaSHV-98, blaSHV-145, blaTEM-1B, aadA2, catA2, catII, dfrA16, fosA, oqxA, oqxB, sul1, sul2, and tet(D).
Identification and characterisation of colistin-resistant Acinetobacter colistiniresistens co-producing IMP-1 and OXA-58 carbapenemases.
The study identifies and characterizes a colistin-resistant Acinetobacter colistiniresistens isolate co-producing IMP-1 and OXA-58 carbapenemases. The isolate exhibits resistance to multiple antibiotics, including carbapenems, cephalosporins, and polymyxins, and harbors several resistance genes such as blaIMP-1, blaOXA-58, and eptA-like, which contribute to its multidrug-resistant phenotype.
Genome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
The study identified various AMR genes in Shigella isolates from Fujian Province, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CTX-M-64), macrolide resistance genes (mphA, ermB), tetracycline resistance genes (tetA, tetB), aminoglycoside resistance genes (aadA, aph(3')-Ib, aac(3)-IId), chloramphenicol resistance gene (catA1), and sulfonamide/trimethoprim resistance genes (sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA17).
The role of New World vultures as carriers of environmental antimicrobial resistance.
The study identified several antimicrobial resistance genes (ARGs) in environmental samples collected from New World vultures, including blaTEM, sul1, ermA, ermF, tetA, and tetB, which confer resistance to beta-lactams, sulfonamides, macrolides, and tetracyclines. These genes were detected in Escherichia coli, enterococci, and Salmonella spp. across different sampling sites and seasons.
Increased Severity of Multidrug-Resistant Shigella sonnei Infections in People Experiencing Homelessness.
The study identifies a clonal expansion of multidrug-resistant Shigella sonnei (genotype 3.6.1.1.2) with resistance to multiple antibiotics, including ampicillin, trimethoprim-sulfamethoxazole, ciprofloxacin, and azithromycin.
Genomic surveillance detects interregional spread of New Delhi metallo-beta-lactamase-1-producing Providencia stuartii in hospitals, Romania, December 2021 to September 2023.
The study identifies the spread of NDM-1-producing Providencia stuartii in Romania, highlighting the presence of multiple resistance genes including bla NDM-1, bla OXA-10, bla CMY-4, bla CMY-16, bla CMY-194, qnrD2, armA, aph(3')-VI, aac(6')-Ib3, rmtC, dfrA14, dfrA12, sul1, and sul2.
First Detection of High-Level Aminoglycoside-Resistant Klebsiella pneumoniae and Enterobacter cloacae Isolates Due to 16S rRNA Methyltransferases with and Without bla(NDM) in Uruguay.
The study identifies the first detection of high-level aminoglycoside-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates in Uruguay, carrying 16S rRNA methyltransferases (rmtB, rmtC, rmtD) along with carbapenemase genes (bla NDM-5, bla NDM-1).
Data-Driven Approaches in Antimicrobial Resistance: Machine Learning Solutions.
This study uses unsupervised machine learning to identify patterns in AMR genes, linking gene length and resistance class to resistance mechanisms. Key AMR genes identified include sul1, sul2, cat, blaTEM, vanA, aac(6')-Ib, aph(3')-IIIa, tet(M), and tet(O).
Salmonella Typhi Haplotype 58 biofilm formation and genetic variation in isolates from typhoid fever patients with gallstones in an endemic setting in Kenya.
The study identified multidrug resistance genes sul1, dfrA7, catA1, aph(6)-Id, aph(3" )-Ib, sul2, and blaTEM-1 in S. Typhi isolates from household D, along with specific mutations in the quinolone resistance-determining region (QRDR) of gyrA and gyrB. Additionally, missense mutations in the treB and tviE genes were observed in isolates from different households.
Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients.
The study identified multiple AMR genes and mutations in multidrug-resistant Shigella strains, including beta-lactamases, macrolide resistance genes, quinolone resistance genes, and chromosomal mutations contributing to fluoroquinolone resistance.
Two outbreak cases involving ST65-KL2 and ST11-KL64 hypervirulent carbapenem-resistant Klebsiella pneumoniae: similarity and diversity analysis.
The study identifies two outbreak cases of hypervirulent carbapenem-resistant Klebsiella pneumoniae (hvCRKP) strains, ST65-KL2 and ST11-KL64, highlighting their distinct resistance mechanisms and virulence profiles.
Microbial spectrum and resistance of odontogenic abscesses - microbiological analysis using next generation sequencing.
The study identified multiple AMR genes in odontogenic abscesses using NGS, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, chloramphenicol, sulfonamides, penicillins, and others. Notably, Fusobacterium showed resistance to clindamycin.
Genomic perspective on the bacillus causing paratyphoid B fever.
The study identified mutations in the gyrA gene associated with reduced susceptibility to fluoroquinolones in Salmonella enterica serotype paratyphi B strains.
Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307.
The study identifies the colistin resistance gene mcr-8.1 in multidrug-resistant Klebsiella pneumoniae ST307 isolates from Armenia, highlighting the emergence of this gene in the region.
Fecal carriage of ESBL-producing E. coli and genetic characterization in rural children and livestock in the Somali region, Ethiopia: a one health approach.
The study identified bla CTX-M-15 as the most prevalent ESBL gene in both human and animal E. coli isolates, along with other resistance genes such as bla TEM-1B, bla OXA-1, and various aminoglycoside, sulfonamide, and trimethoprim resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Phenotypic and genotypic characterization of clinical carbapenem-resistant Acinetobacter species harboring the metallo-beta-lactamases IMP-8 or NDM-1 in China.
The study characterized the phenotypic and genotypic features of one IMP-8-producing and four NDM-1-producing plasmids in Acinetobacter spp. strains isolated in 2010, highlighting the presence of various resistance genes including blaIMP-8, blaNDM-1, aac(6')-Ib, aac(3)-IId, msr(E), mph(E), sul1, sul2, tet(39), and aph(3')-VI.
Epidemiology and Molecular Characterisation of Multidrug-Resistant Escherichia coli Isolated from Cow Milk.
The study identified several AMR genes in multidrug-resistant E. coli isolates from cow milk, including bla TEM, bla CTX-M, bla OXA-1, bla OXA-2, bla CMY-1, tet A, tet B, tet D, sul -1, and sul -2, which confer resistance to various antibiotics.
Genomic and metabolic characterization of Trueperella pyogenes isolated from domestic and wild animals.
The study identified multiple antimicrobial resistance (AMR) genes in Trueperella pyogenes, including tet(W/32/O), erm(X), vanG, sul1, and qacEdelta1, which confer resistance to tetracyclines, MLS B, glycopeptides, sulfonamides, and biocides, respectively. These genes were detected in various T. pyogenes isolates from different animal hosts and body sites, highlighting the genetic diversity and potential for AMR dissemination among different hosts.
Diversity and Resistance Profiles of ESBL-Producing Gram-Negative Bacteria from Dairy Farms in Southern Türkiye.
The study identified ESBL-producing Gram-negative bacteria, including E. coli and C. freundii, carrying the blaCTX-M-15 gene, along with additional resistance genes such as qnrS1, sul1, aadA5, dfrA17, and mph(A). These genes conferred resistance to various antibiotics, highlighting the spread of multidrug-resistant strains in dairy farms in southern Türkiye.
Tracking Multidrug Resistance in Gram-Negative Bacteria in Alexandria, Egypt (2020-2023): An Integrated Analysis of Patient Data and Diagnostic Tools.
The study identified bla NDM-5 as the most prevalent carbapenemase gene in E. coli isolates from Alexandria, Egypt, along with other resistance genes such as bla OXA-48, bla VIM, bla CTX-M-15, aadA2, aac(6')-Ib, qnrS1, dfrA12, sul1, and sul2.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Emerging carbapenem-resistant Klebsiella pneumoniae in a tertiary care hospital in Lima, Peru.
The study identifies blaNDM-1, blaKPC-2, and blaIMP-74 as the primary carbapenem resistance genes in CRKP isolates from Lima, Peru. Additionally, aac(6')-Ib and sul1 were found to confer resistance to aminoglycosides and sulfonamides, respectively.
Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic Escherichia coli and Staphylococcus aureus Strains?
The study identified several antibiotic resistance genes in clinical strains of Staphylococcus aureus and Escherichia coli, including blaZ, grlA, grlB, gyrA, mecA, ermC, aph(6)-Id, aph(3")-Ib, aadA5, blaCTX-M-27, mph(A), sul1, sul2, tet(A), and dfrA17. These genes confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, aminoglycosides, sulfonamides, tetracyclines, and macrolides.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Evidence of dissemination of a clc-type integrative and conjugative element to Stenotrophomonas maltophilia, mediating acquisition of sul1 and other resistance determinants.
The study reports the isolation of a Stenotrophomonas maltophilia strain carrying a clc-type integrative and conjugative element (ICE) that mediates the acquisition of multiple resistance determinants, including sul1, blaVIM-1, aac(6')-Ib, aac(6')-31, qacE∆1, cld, and merEDAPTR.
Whole-genome sequencing-based characterization of Salmonella enterica Serovar Enteritidis and Kentucky isolated from laying hens in northwest of Iran, 2022-2023.
The study identified the presence of a multidrug-resistant (MDR) Salmonella enterica serovar Kentucky ST198 clone with high-level ciprofloxacin resistance due to double mutations in gyrA (S83F, D87N) and parC (T57S, S80I) genes. The aminoglycoside resistance gene aac(6′)-Iaa was the most frequently detected gene, but it did not confer resistance to aminoglycosides. Other resistance genes included tetA, floR, sul1, dfrA1, and aph(3′)-Ia.
Prevalence and genomic insights of carbapenem resistant and ESBL producing Multidrug resistant Escherichia coli in urinary tract infections.
The study identified multiple AMR genes, including NDM-5, CTX-M-15, TEM-1, and others, in carbapenem-resistant and ESBL-producing multidrug-resistant E. coli isolates from urinary tract infections.
Highly drug resistant clone of Salmonella Kentucky ST198 in clinical infections and poultry in Zimbabwe.
The study identifies multiple AMR genes and mutations in Salmonella Kentucky ST198 strains from Zimbabwe, highlighting their multidrug resistance and the presence of specific resistance mechanisms such as blaCTX-M-14.1 and mutations in gyrA and parC.
Clonal Spread and Genetic Mechanisms Underpinning Ciprofloxacin Resistance in Salmonella enteritidis.
The study identified multiple plasmid-mediated quinolone resistance (PMQR) genes, including aac(6')-Ib-cr, qnrA, qnrS, and oqxAB, as well as GyrA mutations (S83Y, D87Y, S83Y-D87Y, S83R, D87N, D87G) in ciprofloxacin-resistant Salmonella enteritidis isolates. These genes and mutations were found to contribute to ciprofloxacin resistance through various mechanisms, including efflux pump overexpression and enzymatic modification of antibiotics.
The Difference a Year Can Make: How Antibiotic Resistance Mechanisms in Pseudomonas aeruginosa Have Changed in Northwestern Transylvania.
The study identified an increase in multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates in Northwestern Transylvania, Romania, between 2022 and 2023. Key AMR genes included bla OXA-50, sul1, ermB, mexA, mexB, bla VIM-1, aac(6′)-II, ant(4′)-Ia, aac(3)-I, aac(6′)-Im, aph(2″)-Ib, tetA, tetC, tetK, qnrB, ermC, mphC, fosA, nfsA, nfsB, ampC, and TEM-1.
Clonality and the Phenotype-Genotype Correlation of Antimicrobial Resistance in Acinetobacter baumannii Isolates: A Multicenter Study of Clinical Isolates from Romania.
The study identifies several AMR genes in Acinetobacter baumannii isolates, including bla OXA-23-like, bla OXA-24/40-like, bla NDM, ArmA, ant(3")-I, and sul1, which are associated with resistance to carbapenems, aminoglycosides, and sulfonamides.
Molecular Epidemiology and In-Depth Characterization of Klebsiella pneumoniae Clinical Isolates from Armenia.
The study identifies multiple AMR genes and mutations in K. pneumoniae isolates from Armenia, highlighting the presence of XDR and MDR strains with resistance to various antibiotics, including carbapenems, aminoglycosides, and quinolones.
Genetic analysis reveals the genetic diversity and zoonotic potential of Streptococcus dysgalactiae isolates from sheep.
The study identified tet(M), tet(O), and erm(B) as the primary AMR genes in S. dysgalactiae isolates from sheep, contributing to resistance against doxycycline and erythromycin.
Metatranscriptomic time series insight into antibiotic resistance genes and mobile genetic elements in wastewater systems under antibiotic selective pressure.
The P14171 gene, encoding a class A beta-lactamase, was identified as the primary antibiotic resistance gene responding to ampicillin in activated sludge systems, highlighting its potential health risks and role in resistance mechanisms.
Cockroaches as Reservoirs, Vectors, and Potential Sentinels of Multidrug-Resistant Bacteria in Ugandan Communities: A Retrospective Analysis.
The study identified tetracycline and sulfonamide resistance genes (tetA, sul1, sul2) in Escherichia coli and tetracycline resistance genes (tetM, tetL) in Enterococcus spp. from cockroaches in Ugandan communities.
Emerging multi-drug resistant and extended-spectrum β-lactamase (ESBL)-positive enterotoxigenic E. coli (ETEC) clones circulating in aquatic environments and in patients.
The study identifies bla CTX-M-15, qnrS1, dfrA17, aadA5, and sul1 as key AMR genes in ESBL-positive ETEC clones circulating in aquatic environments and in patients.
Occurrence of "under-the-radar" antibiotic resistance in anthropogenically affected produce.
The study identifies several clinically relevant AMR genes, including beta-lactamases (bla CTX-M, bla TEM, bla SHV, bla VIM-1), aminoglycoside resistance genes (aadA5, dfrA17, mph(A)), quinolone resistance gene (qnrS1), and sulfonamide resistance gene (sul1), which were found in anthropogenically affected lettuce samples. These genes were associated with multidrug-resistant (MDR) Enterobacteriaceae and were capable of horizontal gene transfer.
Tracing the evolution: the rise of Salmonella Thompson co-resistant to clinically important antibiotics in China, 1997-2020.
The study identifies the IncC plasmid as a major driver of co-resistance to ciprofloxacin, cefotaxime, and azithromycin in Salmonella Thompson isolates in China, with specific resistance genes including qnrS1, qepA4, blaCMY-2, and mph(A).
Abundance of clinically relevant antimicrobial resistance genes in the golden jackal (Canis aureus) gut.
The study identified a high prevalence of clinically relevant antimicrobial resistance genes in golden jackals, including beta-lactamases (bla TEM-1, bla CTX-M-15, bla SHV), quinolone resistance (qnrS), and class 1 integrons (Int1).
Genomic epidemiology and antimicrobial resistance of Morganella clinical isolates between 2016 and 2023.
The study identified several AMR genes in Morganella clinical isolates, including tet(B), sul1, catA2, sul2, floR, aadA1, and others, contributing to resistance against various antibiotics.
Genomic insights into plasmid mediated AMR genes, virulence factors and mobile genetic elements in raw milk Escherichia coli from Gujarat, India.
The study identified multiple antibiotic resistance genes in E. coli isolates from raw milk in Gujarat, India, including beta-lactamases, quinolone resistance genes, efflux pumps, folate pathway antagonists, aminoglycoside resistance genes, and tetracycline resistance genes.
Eradication of Helicobacter pylori reshapes gut microbiota and facilitates the evolution of antimicrobial resistance through gene transfer and genomic mutations in the gut.
H. pylori eradication led to the enrichment of various AMR genes, including beta-lactamases, macrolide phosphotransferases, erythromycin ribosome methyltransferases, sulfonamide resistance proteins, tetracycline efflux pumps, dihydrofolate reductase, quaternary ammonium compound efflux pumps, and aminoglycoside phosphotransferases. Additionally, genomic mutations in parC, parE, and gyrA were associated with fluoroquinolone resistance in E. coli.
Circulation of a Unique Klebsiella pneumoniae Clone, ST147 NDM-1/OXA-48, in Two Diverse Hospitals in Calabria (Italy).
The study identifies multiple AMR genes, including bla OXA-48, bla NDM-1, bla CTX-M-15, and bla SHV, in K. pneumoniae strains from two hospitals in Calabria, Italy, highlighting the presence of multidrug-resistant clones.
Exogenous plasmid capture to characterize tetracycline-resistance plasmids in sprouts obtained from retail in Germany.
The study identified tetracycline resistance genes tet(A) and tet(D), along with quinolone, sulfonamide, and trimethoprim resistance genes qnrS1, sul1, and dfrA1 in plasmids from sprout samples.
Molecular characterization of resistance and biofilm genes of ESKAPE pathogens isolated from clinical samples: examination of the effect of boric acid on biofilm ability by cell culture method.
The study identified various AMR genes in ESKAPE pathogens, including vanA and vanC for vancomycin resistance, blaKPC and blaOXA-48 for carbapenem resistance, and others related to tetracycline, sulfonamide, quinolone, and aminoglycoside resistance. Additionally, biofilm-related genes such as icaA, icaD, gelE, asa1, and esp were detected in Staphylococcus and Enterococcus spp. Quorum sensing genes LasI and LasR were found in Pseudomonas aeruginosa, and biofilm production genes like mrkA, wbbM, wzm, and luxS were identified in Klebsiella pneumoniae.
Epidemic trend of Salmonella from swines and broilers in China from 2014 to 2023 and genetic evolution analysis of ESBLs-producing strains.
The study identified several AMR genes in ESBL-producing Salmonella strains from swines and broilers in China, including blaCTX-M-14, blaTEM-1B, blaCTX-M-65, aac(6')-Iaa, floR, sul2, tet(B), arr-2, fosA3, dfrA12, mph(A), lnu(F), blaCTX-M-55, blaOXA-1, sul1, tet(A), catB3, qnrS1, and mcr-1.1. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, sulfonamides, tetracyclines, rifampicin, fosfomycin, trimethoprim, macrolides, lincomycin, quinolones, and colistin.
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
The study identified various AMR genes and mutations in Salmonella Enteritidis isolates from Spain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and aminoglycoside resistance genes. Chromosomal mutations in the gyrA gene were also found to contribute to quinolone resistance.
Wastewater based genomic surveillance key to population level monitoring of AmpC/ESBL producing Escherichia coli.
The study identified various AMR genes and mutations in AmpC/ESBL-producing E. coli from wastewater samples in Finland, highlighting the prevalence of blaCTX-M-15, blaCTX-M-27, and other resistance determinants.
Avian-specific Salmonella transition to endemicity is accompanied by localized resistome and mobilome interaction.
The study identifies several antimicrobial resistance genes, including bla TEM-1B, sul2, and tet(A), which are prevalent in Salmonella enterica serovar Gallinarum isolates. These genes contribute to the resistome diversity and are associated with specific lineages and geographical regions.
Drug resistance and genotyping studies of Salmonella Enteritidis isolated from broiler chickens in Iran.
The study identified several AMR genes in Salmonella Enteritidis isolates from broiler chickens in Iran, including bla TEM, tet A, tet B, sul 1, and str A/B, which conferred resistance to various antibiotics.
Fecal carriage and molecular characterization of carbapenem-resistant Enterobacteriaceae from hospitalized children in a tertiary hospital of Shandong, China.
The study identified bla NDM-1, bla NDM-5, and bla OXA-1 as the most prevalent carbapenemase genes in CRE isolates from hospitalized children in Shandong, China. Additional resistance genes such as bla CTX-M-55, bla CTX-M-15, sul 1, tet A, and mcr-1.26 were also characterized.
Preliminary survey of biofilm forming, antibiotic resistant Escherichia coli in fishes from land based aquaculture systems and open water bodies in Bangladesh.
The study identified several antibiotic resistance genes, including blaTEM, blaSHV, blaCTX, sul1, and the biofilm-forming gene fimC, in Escherichia coli isolates from both wild and cultured fish in Bangladesh.
Microplastics enhance the prevalence of antibiotic resistance genes in mariculture sediments by enriching host bacteria and promoting horizontal gene transfer.
Microplastics enhance the prevalence of antibiotic resistance genes in mariculture sediments by enriching host bacteria and promoting horizontal gene transfer.
Detection of a genetically related carbapenemase-producing Escherichia coli ST167 in clinical and environmental isolates: Evidence for clonal spread of carbapenemase-producing Enterobacteriaceae in humans and the environment in Iowa, United States.
The study identifies a carbapenemase-producing E. coli strain BO1 carrying bla NDM-5, along with other resistance genes, highlighting the clonal spread of carbapenemase-producing Enterobacteriaceae between humans and the environment in Iowa.
Whole-genome sequencing-based species classification, multilocus sequence typing, and antibiotic resistance mechanisms of the clinical Aeromonas complex.
The study identified multiple beta-lactamase genes, including bla NDM-1, bla PER-3, and bla OXA-1, along with other resistance genes such as aac(6′)-Ib-cr6, aph(3″)-Ib, and floR, which contribute to resistance against various antibiotics in Aeromonas isolates.
Carbapenem-Resistant, Virulence Plasmid-Harboring Klebsiella pneumoniae, United States.
The study identifies six pVir-CRKP isolates from the United States, highlighting their multidrug resistance and enhanced virulence traits. These isolates exhibit resistance to various antibiotics, including carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, due to the presence of specific AMR genes and mutations.
Broiler litter moisture and trace metals contribute to the persistence of Salmonella strains that harbor large plasmids carrying siderophores.
The study identified several antimicrobial resistance genes in Salmonella strains isolated from broiler litter, including aadA1, aac(3)-IV, aph(3′)-Ia, aph(4)-Ia, dfrA14, floR, sul1, tetA, sul2, merRTPCA, qacE, aph(3″)-Ib, aph(6)-Id, pcoABCDRE, silP, and silE. These genes were found on various plasmids and contributed to resistance against multiple antibiotics such as streptomycin, chloramphenicol, sulfamethoxazole, tetracycline, mercury, quaternary ammonium compounds, copper, and silver.
Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from blood cultures.
The study presents a rapid whole-genome sequencing workflow (LC-WGS) for diagnosing bloodstream infections, demonstrating accurate identification of bacterial pathogens and detection of clinically relevant resistance markers within 4.2 hours. The workflow successfully identified various AMR genes, including bla CTX-M-15, bla DHA-1, bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-23, armA, mecA, vanRSHAXYZ, aac(6')-Ie/aph(2'')-Ia, aph(3')-IIIa, aac(6')-I, sul1, and dfrA17.
Whole-Genome Sequencing of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Isolated from Human Bloodstream Infections.
The study identified multiple AMR genes in ESBL-producing K. pneumoniae isolates, including blaCTX-M-15, blaKPC-3, and others conferring resistance to β-lactams, aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and chloramphenicol.
Isolation, Identification, and Characteristics of Aeromonas salmonicida subsp. masoucida from Diseased Starry Flounder (Platichthys stellatus).
The study identified 11 antimicrobial resistance genes in Aeromonas salmonicida subsp. masoucida strains isolated from diseased starry flounders, including genes conferring resistance to beta-lactams, tetracyclines, sulfonamides, chloramphenicol, and biocides.
Molecular Characterization and Antimicrobial Resistance Evaluation of Listeria monocytogenes Strains from Food and Human Samples.
The study identified several intrinsic antimicrobial resistance genes in Listeria monocytogenes strains, including fosX, norB, sul, and lmo0919, which confer resistance to fosfomycin, quinolones, sulfonamides, and lincosamides, respectively.
Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals.
The study identified several antimicrobial resistance genes in uropathogenic E. coli strains from companion animals, including blaTEM-1b, sul1, sul2, dfrA1_10, dfrA17_1, dfrA1_8, dfrA7_5, gyrA_S83L, tetA, tetB, aph(6)-Id, aph(3'')-Ib, ant(3'')-Ia, blaCTX-M-15, blaTEM-106, blaSHV-102, and blaCMY-2. These genes confer resistance to various antibiotics such as penicillins, sulfonamides, trimethoprim, quinolones, tetracyclines, streptomycin, and cephalosporins.
Prevalence, antibiotic resistance, virulence and antimicrobial resistance gene profiles of Salmonella species recovered from retail beef and poultry processing environments.
The study identified the presence of resistance genes bla TEM, tetA, and sul1 in Salmonella isolates from retail beef and poultry processing environments, indicating high levels of antimicrobial resistance.
Strict relationship between phenotypic and plasmid-associated genotypic of multidrug-resistant Escherichia coli isolated from Taihe Black-Boned Silky Fowl farms.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from Taihe Black-Boned Silky Fowl farms, including blaTEM, blaOXA-10, tetA, tetR, floR, cmlA, qnrS, strA, strB, aadA, aac(3)-IId, sul, and dfrA. These genes were associated with resistance to beta-lactams, tetracyclines, chloramphenicol, fluoroquinolones, aminoglycosides, and sulfonamides.
Polyclonal carbapenemase-producing Escherichia coli in Northern Italy: the emergence of NDM-7.
The study identifies the emergence of NDM-7 in polyclonal carbapenemase-producing E. coli in Northern Italy, highlighting the presence of various carbapenemase genes such as bla KPC-3, bla VIM-1, and bla NDM-7, along with other resistance genes.
Comprehensive genomic epidemiology and antimicrobial resistance profiles of clinical Klebsiella pneumoniae species complex isolates from a tertiary hospital in Wenzhou, China (2019-2021).
The study identified a variety of antimicrobial resistance genes in clinical Klebsiella pneumoniae species complex isolates, including bla KPC−2, bla CTX−M, bla SHV, aac(6')-Ib, aadA1, aadA2, aph(3')-Ia, oqxAB, qnrB19, qnrS1, tet(A), tet(D), sul1, sul2, sul3, cmlA1, floR, fosA, and fosA3. These genes confer resistance to multiple classes of antibiotics, highlighting the complexity of antimicrobial resistance in these isolates.
Role of lactoferrin in the treatment of E. coli-induced bovine mastitis.
The study identified BlaTEM, aadB, and Sul1 as the resistance genes in E. coli isolates from bovine mastitis cases, with all isolates showing resistance to gentamycin, ampicillin, cefquinome, cefixime, and sulfamethoxazole-trimethoprim.
Antimicrobial Resistance in Livestock and Its Impact on Public Health
The study highlights the role of livestock environments as reservoirs for antimicrobial resistance genes, identifying blaCTX-M-1, tetA, qnrS, and sul2 as key contributors to resistance in Escherichia coli, Salmonella spp., and Staphylococcus spp.
Real-time investigation of a Burkholderia cenocepacia bacteraemia outbreak in a Vietnamese intensive care unit.
The study identified acquired antimicrobial resistance genes in B. cenocepacia isolates from a bacteraemia outbreak, including aphA6, blaNDM-1, blaPME-1, sul1, and tetG, which conferred resistance to aminoglycosides, carbapenems, sulfonamides, and tetracyclines. No acquired AMR genes were found in the STNF outbreak isolates.
Providencia pseudovermicola sp. nov.: redefining Providencia vermicola and unveiling multidrug-resistant strains from diabetic foot ulcers in Egypt.
The study identifies multiple multidrug-resistant genes in Providencia pseudovermicola sp. nov., including bla CTX-M-14, bla CMY-6, bla NDM-1, qnrD1, aadA, armA, msrE, mphE, lnuF, rmtC, aac(6')-Ib10, sul1, aph(3')-Ia, qacEΔ1, and dfrA1, highlighting the significance of these genes in conferring resistance to various antibiotics.
Potential pathogens drive ARGs enrichment during biofilms formation on environmental surfaces.
The study identifies several antibiotic resistance genes (ARGs) such as sul1, sul2, ermF, and intI-1 that are enriched in biofilms on environmental surfaces, highlighting the role of potential pathogens in ARG dissemination.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Intestinal and Extraintestinal Pathotypes of Escherichia coli Are Prevalent in Food Prepared and Marketed on the Streets from the Central Zone of Mexico and Exhibit a Differential Phenotype of Resistance Against Antibiotics.
The study identifies multiple antibiotic resistance genes in E. coli isolates from street-prepared food in Mexico, including strA, sul1, catA1, floR, qnrS, and tetA, which confer resistance to streptomycin, sulfonamides, chloramphenicol, quinolones, and tetracycline.
Wild Birds as Drivers of Salmonella Braenderup and Multidrug Resistant Bacteria in Wetlands of Northern Italy.
The study identifies several AMR genes in bacterial isolates from wild aquatic birds in Northern Italy, including beta-lactamases (blaTEM, blaCMY-1, blaCMY-2, blaNDM, blaKPC), colistin resistance genes (mcr-2, mcr-3, mcr-4), tetracycline resistance genes (tetA, tetB, tetC, tetL, tetM, tetK), macrolide resistance genes (ermB, vatD, vgA, msrC), vancomycin resistance genes (vanC1, vanC2, vanM, vanG), sulfonamide resistance genes (sul1, sul2, sul3), aminoglycoside resistance genes (aac(3), aac(6')-Ib, aph(3')-Ia, armA, rmtB, rmtC, rmtF), and nitrofurantoin resistance genes (nfsA, nfsB).
Occurrence and characterization of Salmonella isolates from commercial eggs in Phayao Province, Thailand.
The study identified Salmonella contamination in eggshells from three different production systems, with one isolate showing resistance to sulfamethoxazole/trimethoprim due to the presence of sul1 and sul2 genes.
AmrProfiler: A Comprehensive Tool for Antimicrobial Resistance Gene Detection and Analysis
AmrProfiler identifies a wide range of AMR genes and mutations across multiple bacterial species, demonstrating high accuracy and broader species coverage compared to existing tools.
Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.
The First Case of Antimicrobial-Resistant Salmonella Stanley ST29 Diagnosed Secondary to Acute Cholecystitis.
The study identifies multiple antimicrobial resistance genes in Salmonella Stanley ST29, including beta-lactamases, quinolone resistance genes, macrolide resistance genes, and others, contributing to resistance against various antibiotics.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
Molecular characterization of multidrug-resistant E. coli recovered from diarrheagenic children under 5 years from Mukuru Informal Settlement, Nairobi, Kenya, based on whole-genome sequencing analysis.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from diarrheagenic children in Nairobi, Kenya, highlighting the presence of blaTEM-1B, blaCTX-M-15, qnrS1, qnrB4, aac(6')-Ib-cr, and other resistance mechanisms.
Occurrence and Genotypic Characterization of Selected Multidrug-resistant ESKAPE-E Pathogens Isolated from Integrated Smallholder Fresh Produce Farms.
The study identified several AMR genes, including mcr-9 (colistin resistance), blaOXA-like and blaPAO-like (beta-lactam resistance), catB (chloramphenicol resistance), sul (sulfonamide resistance), tet(A) (tetracycline resistance), mdf(A)_1 (macrolide resistance), and formA (formaldehyde resistance) in various ESKAPE-E pathogens isolated from smallholder farms in South Africa.
Comparative genomics of Salmonella enterica serovars Paratyphi A, Typhi and Typhimurium reveals distinct profiles of their pangenome, mobile genetic elements, antimicrobial resistance and defense systems repertoire.
The study compares the pangenome, mobile genetic elements, antimicrobial resistance, and defense systems of Salmonella enterica serovars Paratyphi A, Typhi, and Typhimurium, revealing distinct profiles in their genomic structures and resistance mechanisms.
Antimicrobial resistance and genetic diversity of Escherichia coli isolated from marine bivalves.
The study identified several AMR genes in E. coli isolates from marine bivalves, including bla TEM, bla CTX-M9, bla SHV, bla CTX-M2, bla CTX-M8/25, qnrS, qnrB, sul1, and sul2. These genes were associated with resistance to various antibiotics, highlighting the role of marine environments in the dissemination of AMR.
Whole genome sequencing reveals virulence-mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria.
The study identified multidrug-resistant Escherichia coli isolates from Nigeria, highlighting the presence of virulence genes and mobile genetic elements, along with specific mutations in gyrA and parC that confer resistance to fluoroquinolones.
Potential pathogens and antimicrobial resistance genes in household environments: a study of soil floors and cow dung in rural Bangladesh.
The study identified multiple antimicrobial resistance genes (ARGs) in soil floors and cow dung samples from rural Bangladesh, including sul1, tet(Q), ermF, mexF, and cfxA2, which confer resistance to sulfonamides, tetracycline, macrolides, lincosamides, streptogramins, and cephalosporins.
OXA-204 Carbapenemase in Clinical Isolate of Pseudomonas guariconensis, Tunisia.
The study reports the isolation of a Pseudomonas guariconensis clinical isolate producing OXA-204 carbapenemase, highlighting the spread of OXA-48-like genes beyond Enterobacterales. The isolate exhibited resistance to multiple antibiotics due to the presence of various resistance genes, including blaOXA-204, blaCMY-16, blaDHA-1, and others.
Emergence and characteristics of multidrug-resistant Salmonella enterica subspecies enterica serovar Infantis harboring the pESI plasmid in chicken slaughterhouses in South Korea.
The study identifies multidrug-resistant Salmonella enterica subsp. enterica serovar Infantis isolates harboring the pESI plasmid, which carries genes such as bla CTX-M-65, aadA1, dfrA14, sul1, tetA, and floR, leading to resistance against multiple antibiotics including third-generation cephalosporins.
An integrated multi-mode detection platform based on CRISPR/Cas 12a and aptamers for ultra-sensitive identification of sulfamethazine and genes associated with sulfonamide resistance.
The study presents a multi-mode detection platform combining CRISPR/Cas12a and aptamers for the ultra-sensitive identification of sulfamethazine (SMZ) and the sulfonamide resistance gene sul1. The platform utilizes magnetic separation, nanozymes, and CRISPR/Cas12a for the detection of SMZ and sul1 with high sensitivity and specificity.
High-throughput clinical antimicrobial susceptibility testing and drug-resistant subpopulation detection in Gram-negative bacteria.
The study introduces the EZMTT method for enhanced detection of drug-resistant subpopulations in Gram-negative bacteria, showing superior sensitivity compared to conventional methods like BMD and VITEK. It identifies specific resistance genes such as bla in clinical isolates.
Prevalence and molecular characterisation of multi-drug resistant ST11 hypervirulent Klebsiella pneumoniae in a teaching hospital.
The study identifies several AMR genes in CRKP strains, including bla KPC-2, bla NDM-1, bla VIM, bla SHV-12, bla TEM-1b, aac(6')-Ib-cr, qnrS, qnrB, rmtB, ant(3'')-I, armA, sul1, sul2, iucA, iutA, iroN, ybtS, mrkD, fimH, and p rmpA. These genes confer resistance to carbapenems, quinolones, aminoglycosides, and sulfonamides. Additionally, the study highlights the transferability of these genes through conjugation.
Integrated genomic-epigenomic-transcriptomic analyses reveal adaptive mechanisms of colistin and carbapenem resistance in Klebsiella pneumoniae and Enterobacter isolates
The study identifies multiple AMR genes and mutations associated with colistin and carbapenem resistance in Klebsiella pneumoniae and Enterobacter isolates, including beta-lactamases, fosfomycin resistance genes, and efflux pumps. Mutations in ompK35 were found to contribute to carbapenem resistance.
Local Genomic Epidemiology of Acinetobacter baumannii Circulating in Hospital and Non-hospital Environments in Kano, Northwest Nigeria.
The study identifies various AMR genes in Acinetobacter baumannii isolates from hospital and non-hospital environments in Kano, Nigeria, including bla OXA-66, bla OXA-180, bla ADC-25, aadA1, aph(3')-Ia, aph(3'' )-Ib, aac(3)-Ia, aph(6)-Id, tetB, sul1, and sul2, which confer resistance to beta-lactams, aminoglycosides, tetracyclines, and sulfonamides.
Nationwide surveillance of carbapenem-resistant Gram-negative pathogens in the Lebanese environment.
The study identified carbapenem-resistant Gram-negative bacteria in various environmental samples in Lebanon, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Key resistance genes detected include bla NDM-5, bla OXA-23, bla OXA-66, mexAB-OprM, bla IMP-1, and others, highlighting the widespread presence of carbapenem resistance in the environment.
Genomic and machine learning approaches to predict antimicrobial resistance in Stenotrophomonas maltophilia.
The study identifies key genetic markers associated with resistance to levofloxacin (LEV) and trimethoprim-sulfamethoxazole (SXT) in Stenotrophomonas maltophilia, including mutations in parC, gyrA, and smeT, as well as the presence of sul1, sul2, Gsh2, and gspD genes.
Characterization of the Diversity in Host Range of an Extensively Drug-Resistant (XDR) Type IV Secretion System-Encoding Plasmid in Acinetobacter.
The study characterizes the XDR plasmid p1AB5075, which harbors multiple antibiotic resistance genes, including blaGES-11, aac(6')-Ib10, ant(2")-Ia, aadA2, aph(3")-Ib, aph(6)-Id, cmlA1, dfrA7, sul1, and qacEΔ1, conferring resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, trimethoprim, and sulfonamides. The plasmid was successfully transferred to genetically diverse Acinetobacter strains, highlighting its potential for spreading resistance.
Molecular Identification and Antimicrobial Resistance Characteristics of Extended-Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Isolated from Captive Wild and Migratory Birds.
The study identified extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae in captive wild and migratory birds in Bangladesh, highlighting the presence of resistance genes such as bla TEM-1&2, bla SHV-1, bla OXA-1,4&30, strA, tetA, and sul1, which contribute to multidrug resistance.
Occurrence and Drivers of Antibiotic Resistance Genes Carried by Bacteriophages in Soils Following Different Fertilization Treatments.
The study identified 19 pARG subtypes in soils with different fertilization treatments, highlighting the impact of organic fertilizers on the diversity and abundance of antibiotic resistance genes carried by bacteriophages.
Establishing Clinical and Laboratory Standards Institute M45 antimicrobial susceptibility testing methods and breakpoints for Pseudomonas other than Pseudomonas aeruginosa.
The study established tentative CLSI M45 antimicrobial susceptibility testing breakpoints for Pseudomonas other than Pseudomonas aeruginosa (POPA). It identified various beta-lactamase genes, including metallo-beta-lactamases (MBLs) such as bla POM-1, bla POM-2, bla PAM-1, bla PST-1, bla VIM-2, bla CARB-2, bla DHA-1, and bla IMP-13, which confer resistance to carbapenems. Additionally, multidrug-resistant efflux pumps like ttgABC and tmexCD-toprJ were found to contribute to carbapenem resistance. Other resistance genes for aminoglycosides, trimethoprim-sulfamethoxazole, quaternary ammonium compounds, chloramphenicol, and fluoroquinolones were also detected.
Characterizing antimicrobial resistance and plasmidome diversity in Escherichia coli from imported frozen broiler chicken in the United Arab Emirates.
The study identified several AMR genes in E. coli isolates from imported frozen broiler chicken in the UAE, including bla CTX-M-55, bla CTX-M-8, bla TEM-1B, aadA1, qnrS1, tetA, sul1, sul2, and sul3. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, and sulfonamides.
Multidrug-resistant Klebsiella pneumoniae ST70 harboring bla(NDM) in a migratory Penguin.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Klebsiella pneumoniae ST70 isolate from a Magellanic Penguin, highlighting the potential of migratory penguins as vectors of antimicrobial-resistant microorganisms.
Variants of β-lactamase-encoding genes are disseminated by multiple genetically distinct lineages of bloodstream Escherichia coli.
The study identified multiple β-lactamase genes, including bla TEM-1, bla CTX-M-15, and bla OXA-1, along with other AMR genes such as aadA5, aph(3")-Ib, aph(6)-Id, mphA, sul1, sul2, tetA, dfrA17, and aac(6')-Ib-cr5, which confer resistance to various antimicrobial classes in bloodstream E. coli isolates.
The impact of green spaces, urban settings, seasonal changes, and pollutants on dissemination of antimicrobial genes in air.
The study identified several antimicrobial resistance genes (ARGs) in airborne samples, including blaTEM, mecA, aac(6')-Ib, ermB, ermC, tetM, tetW, sul1, and sul3. It found that the relative abundance of these ARGs varied with vegetation coverage, seasons, and environmental factors. High vegetation areas showed slightly lower ARG abundance compared to urban heat islands and low/no vegetation areas. The study highlights the potential of planting non-allergenic vegetation to reduce airborne ARG dissemination.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Emergence of highly virulent Aeromonas dhakensis in channel catfish aquaculture: Genomic insights into pathogenicity and antimicrobial resistance.
The study identified 60 antibiotic resistance genes in the highly virulent Aeromonas dhakensis strain CWH5, including genes conferring resistance to multiple drug classes such as beta-lactams, tetracyclines, sulfonamides, and macrolides.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Prevalence, aetiology and host and management factors associated with bovine mastitis in dairy cows in Zoba Anseba, Eritrea: a cross-sectional study.
The study identified tetracycline, sulfonamide, and penicillin resistance in Staphylococcus aureus, Enterococcus faecium, and Streptococcus agalactiae isolates from dairy cows in Eritrea.
Pan-drug, colistin, streptomycin, erythromycin, clindamycin resistant Salmonella enterica serovars isolated from slaughtered cattle and human in mansoura, Egypt.
The study identified multiple AMR genes in Salmonella isolates, including aadA1, tetA, sul1, and aac(3)-IV, which conferred resistance to streptomycin, tetracycline, sulfamethoxazole/trimethoprim, and gentamicin, respectively.
Genomic features of three major diarrhoeagenic Escherichia coli pathotypes in India.
The study identifies a variety of acquired antimicrobial resistance (AMR) genes in diarrhoeagenic Escherichia coli (DEC) strains from India, highlighting the prevalence of resistance to multiple antibiotic classes, including aminoglycosides, beta-lactams, sulfonamides, and tetracyclines. Key AMR genes include blaTEM-105, strB, strA, mphA, sul1, sul2, addA1-pm, tetA, tetB, blaCTX-M15, blaCTX-M27, and blaDHA-1. Additionally, mutations in the quinolone resistance-determining regions (QRDRs) of gyrA and parC were found to contribute to fluoroquinolone resistance.
Genomic epidemiology reveals antibiotic resistance transfer and polyclonal dissemination of Acinetobacter baumannii in a Paraguayan hospital.
The study identifies multiple antibiotic resistance genes, including blaOXA-23, ADC-344, ADC-345, blaTEM-1, Sul1, Sul2, and TetB, in Acinetobacter baumannii isolates from a Paraguayan hospital, highlighting the presence of multidrug-resistant strains and horizontal gene transfer of resistance mechanisms.
Prevalence and antimicrobial resistance of Salmonella enterica isolated from cattle farms in Inner Mongolia.
The study identified several AMR genes in Salmonella enterica isolates from Inner Mongolia, including bla TEM-1, cmlA, tetA, tetB, tetM, aadA2, aph(3')-IIa, aacC4, aac(3)-IIa, sul1, sul3, oqxA, and oqxB, which confer resistance to beta-lactams, chloramphenicol, tetracyclines, aminoglycosides, sulfonamides, and quinolones.
Diversity versus clonality in carbapenem-resistant A. baumannii: a two-year surveillance study in four intensive care units at a large teaching hospital in Rome, Italy.
The study identified carbapenem-resistant Acinetobacter baumannii isolates carrying the blaOXA-23 gene and aminoglycoside resistance genes such as armA, aadA2, aph(3')-VIa, and ant(2")-Ia. Other resistance genes included mph(E), msr(E), sul1, sul2, and tet(B).
Molecular and genomic insights into multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa causing burn wound infections in Bangladesh.
The study identified multiple beta-lactamase genes, including blaNDM-1, blaVIM-2, blaPER-1, blaCTX-M, blaOXA-1, and blaOXA-48, as well as efflux pump genes like mexA, mexC, and mexE, contributing to multidrug resistance in P. aeruginosa isolates from burn wound infections in Bangladesh.
Overlooked Enterobacterales as hosts of antimicrobial resistance in aquatic environments.
The study identified several AMR genes in environmental Enterobacterales isolates, including blaTEM-1, blaCTX-M, tetA, tetB, tetC, tetL, tetM, sul1, sul2, qnrS, ermB, and mefA, which conferred resistance to various antibiotics such as ampicillin, ceftazidime, cefepime, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and erythromycin.
Clonal spread of bla(CTX-M-65) producing Salmonella enterica serovars detected in poultry retail meat in North Carolina, USA.
The study identifies the clonal spread of bla(CTX-M-65) producing Salmonella enterica serovars in poultry retail meat in North Carolina, USA. It characterizes the resistance profiles of these isolates, including the presence of bla(CTX-M-65), aac(3)-Iva, aadA1, aph(4)-Ia, floR, mdsA, mdsB, sul1, tet(A), dfrA14, aph(3')-Ia, sul2, aph(3'')-Ib, and fosA3.
Genomic Characterization and Antibiotic Resistance Profiles of Acinetobacter baumannii Isolates From Intensive Care Units in Vietnam.
The study identifies multiple AMR genes in three CRAB isolates, including blaOXA-23, blaOXA-66, blaADC-198, blaADC-73, and various aminoglycoside modifying enzymes, efflux pumps, and sulfonamide resistance genes, highlighting the extensive multidrug resistance in these isolates.
Emergence of carbapenem-resistant Acinetobacter baumannii clonal complex 2 in multiple hospitals in São Paulo state, Brazil.
The study identifies the emergence of carbapenem-resistant Acinetobacter baumannii clonal complex 2 (CC2) in multiple hospitals in São Paulo, Brazil, with resistance genes including blaOXA-23, armA, aadB, aphA1, aphA6, sul1, sul2, and tetB.
Biofilm Formation and Antibiotic Resistance Genes of Escherichia coli From Poultry Farms and Clinical Samples.
The study identified several AMR genes in E. coli isolates from poultry and clinical samples, including blaTEM, gyrA, gyrB, qnrB, qnrB4, qnrS, blaCTX-M, sul1, sul2, tetA, and tetB. These genes conferred resistance to various antibiotics such as beta-lactams, fluoroquinolones, sulfonamides, and tetracyclines. High levels of resistance were observed against tylosin, neomycin, tetracycline, ampicillin, doxycycline, ciprofloxacin, and trimethoprim/sulfamethoxazole.
Comparative genomics of Pseudomonas paraeruginosa.
The study identifies various AMR genes and mutations in Pseudomonas paraeruginosa, including carbapenemases like blaVIM-2, blaVIM-6, blaVIM-28, and blaKPC-2, as well as efflux pump genes (mexAB-oprM, mexCD-oprJ, etc.), and mutations in oprD, mexS, mexR, mexZ, lasR, mvfR, and vqsM that contribute to antibiotic resistance.
Genomic insights into bacteriophages: a new frontier in AMR detection and phage therapy.
The paper discusses the identification of various AMR genes in Acinetobacter baumannii and other pathogens, highlighting their role in resistance to multiple antibiotics and the potential of phage therapy as an alternative treatment.
Detection of the ST111 Global High-Risk Pseudomonas aeruginosa Clone in a Subway Underpass.
The study identifies the ST111 Pseudomonas aeruginosa clone in an urban water drain, highlighting its multidrug resistance profile with genes like aadA2, bla_OXA-10, sul1, and aac(6')-Ib, along with the bla_PDC-3 allele conferring enhanced resistance to certain carbapenems.
Whole-Genome Sequencing of Klebsiella quasipneumoniae subsp. similipneumoniae Isolated from a Patient with Pneumonia.
The study identifies several AMR genes in a multidrug-resistant K. quasipneumoniae subsp. similipneumoniae isolate, including blaSHV-18, blaOXA-2, sul1, ant(2")-Ia, and ompK36, which contribute to resistance against various antibiotics.
Epidemiological and biological characteristics of IncR plasmids as multihost antibiotic resistance carriers.
The study characterizes various AMR genes carried by IncR plasmids, highlighting their role in the dissemination of resistance to carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, and tetracyclines.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
The study identified 50 acquired resistance genes and seven chromosomal-mediated gene mutations in Salmonella populations from Thai canal water, highlighting the prevalence of multidrug-resistant strains and the diversity of resistance mechanisms.
The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital.
The study identified several AMR genes and mutations in colistin-resistant P. aeruginosa isolates, including blaNDM-1, blaOXA-1028, blaOXA-904, and mutations in phoQ and basR genes associated with colistin resistance.
Epidemiology of potential source, risk attribution of Clostridium perfringens from Egyptian broiler farms and genetic diversity of multidrug resistance strains.
The study identified multiple AMR genes in Clostridium perfringens isolates from Egyptian broiler farms, including aminoglycoside, beta-lactam, macrolide, quinolone, sulfonamide, tetracycline, and trimethoprim resistance genes. High prevalence of multidrug-resistant strains was observed.
Epidemiology of potential source, risk attribution of Clostridium perfringens from Egyptian broiler farms and genetic diversity of multidrug resistance strains.
The study identified multiple AMR genes in Clostridium perfringens isolates from Egyptian broiler farms, including aminoglycoside, beta-lactam, macrolide, quinolone, sulfonamide, tetracycline, and trimethoprim resistance genes. High prevalence of multidrug-resistant strains was observed.
Tracking Enterobacteria, microbiomes, and antibiotic resistance genes from waste to soil with repeated compost applications.
The study identifies several AMR genes including bla CTX-M, bla TEM-1B, bla SHV-12, qnr A, qnr B, aac(6')-Ib, sul 1, sul 2, intI 1, and intI 2 in Enterobacteria from composts and raw waste, highlighting their persistence and potential spread in tropical soils.
Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria.
The study characterizes several AMR genes, including blaIPM-4, blaOXA-1, blaOXA-10, aacA4, blaOXA-101, aadA11, aadA9, qacEΔ1, sat2-aadA1, and others, highlighting their role in conferring resistance to various antibiotics in different bacterial species.
Emergence of carbapenem-resistant Salmonella Mbandaka through IS26-driven bla(NDM-1) mobilization and chromosomal structural variation.
The study reports the first documented isolation of a carbapenem-resistant Salmonella Mbandaka strain, highlighting the role of IS26 in the mobilization of blaNDM-1 and chromosomal structural variation.
Genomic characterization of multidrug-resistant clinical Acinetobacter baumannii isolates from a hospital in Paraguay.
The study identified multiple AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Paraguay, including blaOXA-23, blaOXA-66, blaOXA-65, blaADC-73, blaADC-5, blaTEM-1, and various aminoglycoside, macrolide, sulfonamide, chloramphenicol, tetracycline, and trimethoprim resistance genes.
Combatting resistance: natural products as tools to drive the discovery of untapped antibiotic targets.
The paper discusses the mechanisms of antibiotic resistance, focusing on genes such as blaZ, mecA, folP, and sul, which confer resistance to penicillins and sulfonamides. These genes were experimentally validated in the study.
Cefiderocol-resistant pathogens in German hospital wastewater: a reservoir for multidrug resistance.
The study identifies multiple AMR genes, including bla NDM−1, bla VIM−1, bla OXA−48, and bla KPC−2, in cefiderocol-resistant isolates from German hospital wastewater, highlighting the presence of multidrug-resistant pathogens with diverse resistance mechanisms.
Clonal Dissemination of Pandrug-Resistant Klebsiella pneumoniae ST392KL27 in a Tertiary Care Hospital in Mexico.
Outbreak Caused by VIM-1- and VIM-4-Positive Proteus mirabilis in a Hospital in Zagreb.
The study reports an outbreak of carbapenem-resistant Proteus mirabilis in a psychiatric hospital in Zagreb, Croatia, characterized by the presence of VIM-1 and VIM-4 carbapenemases, along with other resistance genes such as bla CTX-M-15, bla TEM, and aminoglycoside resistance genes.
Antimicrobial Resistance of Salmonella and Characterization of Two Mcr-1-Harboring Isolates from Pork Products in Guangdong, China.
Two mcr-1-harboring Salmonella Kentucky ST198 isolates were identified, showing resistance to multiple antibiotics including colistin, tetracycline, and fluoroquinolones. The study highlights the presence of complex resistance determinants such as the multidrug resistance region (MRR) and SGI1-KI.
Molecular and phenotypic characteristics of isolated Escherichia coli from the skin, gills, and intestine of rainbow trout in retail stores of Kerman, Iran.
The study identified several AMR genes in E. coli isolates from rainbow trout, including blaTEM, qnrA, tetB, sul1, and sul2, which confer resistance to beta-lactams, fluoroquinolones, tetracyclines, and sulfonamides.
Towards the integration of antibiotic resistance gene mobility into environmental surveillance and risk assessment.
The study highlights the importance of incorporating antibiotic resistance gene (ARG) mobility into environmental surveillance and risk assessment. It identifies specific ARGs such as bla OXA, bla KPC-2, bla TEM-1, bla GES-2, bla GES-5, sul 1, and sul 2 as highly mobile and potentially risky in various environmental settings.
Molecular insights into the persistence and co-occurrence of two different carbapenem-resistant Pseudomonas aeruginosa lineages within a hospital setting.
The study identifies several carbapenem-resistant Pseudomonas aeruginosa lineages with specific resistance genes, including blaOXA-10, blaVIM-2, and others, highlighting the role of plasmids in the spread of resistance.
Research note: Emergence of bla(NDM-13) producing Escherichia coli from a broiler chicken and farm environment in Jiangsu Province, China.
The study identified blaNDM-13-producing E. coli strains in a chicken farm in Jiangsu Province, China, which exhibit multidrug resistance, including resistance to carbapenems, aminoglycosides, fluoroquinolones, tetracyclines, sulfonamides, and florfenicol. The study also characterizes the plasmids carrying blaNDM-13 and confirms their ability to transfer between bacteria.
Molecular epidemiology of pESI-carrying Salmonella Infantis in Korea: insights from a one health framework.
The study identifies multiple antimicrobial resistance genes and a quinolone resistance mutation in pESI-carrying Salmonella Infantis isolates from the Korean poultry production chain, highlighting the potential for zoonotic transmission.
Global phylogeography and genomic characterization of bla(NDM-1)-positive clinical Proteus mirabilis isolates from China.
The study identifies blaNDM-1 as a key determinant of carbapenem resistance in Proteus mirabilis isolates from China, along with other resistance genes such as blaCTX-M-14, blaCTX-M-65, and blaTEM-1. It also characterizes the genomic context of blaNDM-1, including its integration into SGI1 and plasmid-borne elements.
Heterogeneous Salmonella typhi transmission within a household: genomic insights from a chronic carrier.
The study characterizes AMR genes and mutations in Salmonella Typhi isolates from a household cluster, highlighting the presence of blaTEM-1, aac(6)-Iy, aph(6)-Id, dfrA-7, sul-1, sul-2, and catA-1, along with fluoroquinolone resistance mutations in gyrA and parC.
Navigating an evolving microbial landscape: emerging antimicrobial resistance trends and precision stewardship in Tianjin tertiary hospitals (2021-2023).
The study identified significant trends in antimicrobial resistance (AMR) patterns among clinical isolates from hospitals in Tianjin, highlighting the increasing resistance of Klebsiella pneumoniae to various antibiotics, including carbapenems, and the notable decline in ceftazidime/avibactam resistance in E. coli. Additionally, it noted the emergence of resistance in Acinetobacter baumannii and Pseudomonas aeruginosa to several antimicrobials.
Unveiling community structure, antimicrobial resistance, and virulence factor of a wastewater sample of dairy farm located in mayurbhanj, odisha, india.
The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Dissemination dynamics of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones.
The study characterizes the dissemination of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones in Enterobacter species, highlighting their co-occurrence with other resistance genes and their global distribution.
Whole-Genome Sequencing Uncovers Chromosomal and Plasmid-Borne Multidrug Resistance and Virulence Genes in Poultry-Associated Escherichia coli from Nigeria.
The study identified multiple antimicrobial resistance genes in a multidrug-resistant E. coli strain from poultry in Nigeria, including blaCTX-M-15, blaOXA-1, blaTEM-1, aac(6')-Ib-cr, aadA5, aph(3'')-Ib, sul1, sul2, tet(A), mph(A), and dfrA17, highlighting the role of plasmids in the spread of resistance.
Insights into the Metabolic Adaptations of a Carbapenem-Resistant Klebsiella pneumoniae Strain on Exposure to Sublethal Concentrations of Ertapenem.
The study identified VIM-1, AAC(6')-Ib, APH(3')-Ia, ANT(3'')-Ia, Sul1, and DfrA1 as genes with significant differential abundance in a carbapenem-resistant K. pneumoniae strain exposed to sublethal concentrations of ertapenem, indicating their roles in antibiotic resistance.
Insights into the Metabolic Adaptations of a Carbapenem-Resistant Klebsiella pneumoniae Strain on Exposure to Sublethal Concentrations of Ertapenem.
The study identified VIM-1, AAC(6')-Ib, APH(3')-Ia, ANT(3'')-Ia, Sul1, and DfrA1 as genes with significant differential abundance in a carbapenem-resistant K. pneumoniae strain exposed to sublethal concentrations of ertapenem, indicating their roles in antibiotic resistance.
Multidrug-Resistant Escherichia coli Associated with Respiratory and Systemic Infection in a Domestic Rabbit in Romania: First Confirmed Case.
The study reports the first confirmed case of multidrug-resistant Escherichia coli in a domestic rabbit in Romania, highlighting its pathogenic potential and the need for improved antimicrobial stewardship.
Antimicrobial Resistance and Genomic Characterization of an Escherichia coli Strain Harboring p0111 and an IncX1-Type Plasmid, Isolated from the Brain of an Ostrich.
The study identifies multiple antimicrobial resistance genes in an Escherichia coli strain isolated from an ostrich, including bla CTX-M-55, rmtB, sul1, APH(6)-Id, tet(A), AAC(3)-IIc, aadA2, bla TEM-1B, and floR, which confer resistance to various antibiotics such as cephalosporins, aminoglycosides, sulfonamides, tetracyclines, and chloramphenicol.
Multidrug-Resistant pESI-Harboring Salmonella enterica Serovar Muenchen Sequence Type 82 in Poultry and Humans, Israel, 2020-2023.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
The study identifies 42 antimicrobial resistance (AMR) genes in the pan-drug resistant Klebsiella pneumoniae isolate KPNW, including beta-lactamases (bla CTX-M-15, bla NDM-1, bla OXA-1, bla TEM-63, bla TEM-104, bla SHV-28), tetracycline resistance genes (tet(A)), and efflux pump genes (oqxA, oqxB, marA, marR, ompK37, pbp3, crp, h-ns, kpnG, kpnH, parC, rsmA). Additionally, the isolate shows resistance to polymyxin B and colistin through modifications in lipid A (eptB, arnT, lptD, msbA, vanG) and other mechanisms.
Population structure and antimicrobial resistance of Corynebacterium diphtheriae in Victoria, Australia.
The study identified multiple AMR genes and mutations in contemporary Corynebacterium diphtheriae isolates from Victoria, Australia, including pbp2m, erm(X), aph(3')-Ia, aph(6)-Id, aph(3'')-Ib, tet(W), tet(33), tet(O), cmx, sul1, dfrA15, and mutations in gyrA and rpoB. These genes and mutations confer resistance to various antimicrobials such as penicillin, erythromycin, gentamicin, tetracycline, chloramphenicol, sulfamethoxazole, trimethoprim, ciprofloxacin, and rifampicin.
In-depth characterization of virulence traits, pathogenicity, antibiogram, and antibiotic resistance genes of MDR Vibrio parahaemolyticus retrieved from shrimp.
The study identified multiple antibiotic resistance genes in MDR Vibrio parahaemolyticus strains isolated from shrimp, including bla TEM, bla OXA, tet A, aad A, erm B, and sul 1, which confer resistance to various antibiotics.
Genomic and phenotypic characterization of antimicrobial resistance in clinical Nocardia species isolates.
Whole-genome sequencing reveals Enterobacter hormaechei as a key bloodstream pathogen in six tertiary care hospitals in southwestern Nigeria.
The study identifies several AMR genes in Enterobacter hormaechei and Enterobacter cloacae, including bla ACT-45, bla CTX-M-15, bla NDM-1, dfrA14, mcr10.1, aac(3)-Ile, aph(3′)-Ib, qnrB1, sul1, sul2, tet(A), catA1, and mphA, highlighting the prevalence of multidrug resistance in these species.
Resistance, virulence and genetic diversity of Salmonella Typhimurium in South Africa (1999-2021).
The study identified several AMR genes in Salmonella Typhimurium isolates from South Africa, including beta-lactamases (bla PSE, bla CMY-2, bla TEM, bla SHV), sulfonamide resistance genes (sul1, sul2, sul3), fluoroquinolone resistance genes (qnrA, qnrB, qnrS), tetracycline resistance genes (tetA, tetB), and trimethoprim resistance genes (dfrXI, dfrXII).
No evidence of multidrug-resistant Enterobacterales transmission between healthy companion animals and pet owners in the greater Atlanta area: a pilot study.
The study identified several AMR genes and mutations in E. coli isolates from both humans and pets, including blaCMY-2, blaCTX-M-15, blaTEM-1B, and mutations in gyrA and parC. These findings highlight the presence of multidrug-resistant Enterobacterales in healthy individuals and their companion animals.
Persistent multispecies dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital.
The study identifies the persistent dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital, highlighting the role of these plasmids in the spread of aminoglycoside resistance.
Diversity and antimicrobial resistance among bacterial isolates from finfish aquaculture in Thailand.
The study identified high levels of antimicrobial resistance in bacterial isolates from finfish aquaculture in Thailand, with particular emphasis on beta-lactam, tetracycline, and fluoroquinolone resistance in Gram-negative bacteria, and beta-lactam, macrolide, fluoroquinolone, and peptide resistance in Gram-positive bacteria. Unique resistance gene families, such as the SMR efflux pump and OXA beta-lactamase, were found in Aeromonas spp. and V. vulnificus.
Genomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
The study identified high levels of antimicrobial resistance in Shigella boydii, with over 60% of isolates classified as multidrug-resistant. Key resistance genes included blaCTX-M-15, blaCTX-M-3, blaDHA-1, mphA, sul1, sul2, dfrA1, dfrA14, dfrA5, dfrA12, dfrA17, dfrA7, aadA1, aph(3’’)-Ib, aph(6)-Id, tet(A), and tet(B). Mutations in gyrA and parC were associated with ciprofloxacin resistance and reduced susceptibility.
Azithromycin resistance in nontyphoidal Salmonella in an urban informal settlement in Nairobi, Kenya.
The study identified several AMR genes in nontyphoidal Salmonella isolates, including aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, ant(3")-Ia, sul1, sul2, dfrA1, dfrA8, tetA, mph(A), bla CTX-M-3, bla TEM-135, bla TEM-1B, and bla TEM-1C. These genes conferred resistance to various antibiotics such as aminoglycosides, sulfonamides, tetracycline, macrolides, and beta-lactams.
Whole-Genome Sequencing Analysis of Drug-Resistant Salmonella Typhi in Children.
The study identified several AMR genes and mutations in drug-resistant Salmonella Typhi isolates from children, including bla_CTXM15, bla_TEM1B, qnrS1, aac6'Ia, catA1, dfrA7, sul1, qacEΔ1, and the gyrA_S83F mutation, which are associated with resistance to various antibiotics such as ciprofloxacin, ampicillin, chloramphenicol, and sulfamethoxazole.
Global genomic survey of Salmonella Kentucky: discovery of a chromosomeborne bla(NDM-5) and the emergence of ST314, an MDR clone mediated by the IncR plasmid.
The study discovered a chromosome-borne bla(NDM-5) gene in Salmonella Kentucky and identified the IncR plasmid as a key mediator of antimicrobial resistance in the MDR clone ST314.
Pathogenic potential of amoxicillin-clavulanic acid resistant Klebsiella pneumoniae isolated from aquatic environment: a study of multidrug resistance and virulence.
The study identified several AMR genes in AMC-resistant K. pneumoniae isolates from aquatic environments, including bla TEM, bla SHV, bla CTX-M, bla NDM, bla OXA-48, bla CMY, qnr S, qnr B, tet A, tet B, sul 1, dfr A12, intl 1, intl 2, mrk D, ecp A, and iuc C. These genes were associated with resistance to multiple antibiotics, highlighting the complex resistance profiles of these isolates.
Genetic diversity and antimicrobial resistance profiles of Salmonella enterica in the broiler supply chain in Harare, Zimbabwe: tracking transmission from farm to table.
The study identified several AMR genes and mutations in Salmonella enterica isolates from the broiler supply chain in Zimbabwe, including fosA7.2, qnrB19, aadA1, aph(3'')-Ib, aph(6)-Id, aac(3)-Id, fosA3, sul1, sul3, tetA, cmlA1, blaCMY-2, blaTEM-1B, blaCTX-M-14, and mutations in gyrA and parC. These genes and mutations confer resistance to various antibiotics, including fosfomycin, fluoroquinolones, aminoglycosides, sulfonamides, tetracyclines, chloramphenicol, and beta-lactams.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Bovine mastitis and antimicrobial resistance in Pakistan's dairy sector: current status and future prospects.
The paper highlights the high prevalence of bovine mastitis in Pakistan, particularly caused by Staphylococcus aureus, and discusses the growing concern of antimicrobial resistance (AMR) due to the frequent and often inappropriate use of antibiotics in mastitis management.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
Genomic insights into ST85 and ST158 belonging to recently emerged global clones of multidrug-resistant Acinetobacter baumannii isolates from Egypt: in vitro assessment of repurposed drug-antibiotic combinations.
The study identified multiple antibiotic resistance genes, including blaOXA-23, aadA1, armA, aph(3')-VIa, aph(3')-Ia, and ant(3'')-IIa, in multidrug-resistant Acinetobacter baumannii isolates from Egypt.
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Genetic and virulence factors behind the success of high-risk Pseudomonas aeruginosa clones: insights from comparative genomics and an experimental infection model.
The study identified 15 AMR genes significantly more frequent in high-risk P. aeruginosa clones, including aminoglycoside, beta-lactam, phenicol, fluoroquinolone, trimethoprim, sulfonamide, and tetracycline resistance genes. These genes are often associated with mobile genetic elements, indicating a mobility-linked resistome in high-risk clones.
Multidrug resistant hypervirulent ST307 clone from genomic surveillance of extended spectrum beta-lactamase-producing Klebsiella pneumoniae species complex in East Africa.
The study identifies multiple AMR genes, including blaCTX-M-15, blaTEM-1D, aac(6')-Ib-cr, aadA16, strB, qnrS1, sul2, sul1, catII.2, tet(A), dfrA14, arr-3, and mphA, in ESBL-KpSC isolates from East Africa, highlighting the prevalence of multidrug resistance.
Genomic insights into novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae: a threat from an Indian hospital setting.
The study identifies several AMR genes and mutations in the novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae isolate BB-7, including bla CTX-M-15, bla SHV-28, bla TEM-1, bla OXA-1, bla OXA-232, armA, aadA2, baeR, tetD, adeF, emrR, AAC(6')-Ib-cr6, catI, sul1, mphE, msrE, dfrA1, oqxA, and fosA, as well as mutations in GyrA, ParC, OmpA, OmpK37, and ArnT that confer resistance to multiple antibiotics.
Comparative assessment of annotation tools reveals critical antimicrobial resistance knowledge gaps in Klebsiella pneumoniae.
The study identifies various AMR genes and mutations in Klebsiella pneumoniae, highlighting knowledge gaps in existing annotation tools and databases for accurate resistance prediction.
Genomic islands and plasmid borne antimicrobial resistance genes drive the evolution of high-risk, ST-131 uropathogenic E. coli NS30.
The study identifies multiple antimicrobial resistance (AMR) genes, including blaOXA-1, sul1, aadA5, aac(6')-Ib-cr, catB3, and dfrA17, in the conjugative plasmid pNS30-1 of E. coli NS30. These genes contribute to multidrug resistance and are part of a Tn402-type class 1 integron. The plasmid is capable of horizontal transfer, highlighting its role in the dissemination of AMR.
Multidrug-resistant Klebsiella pneumoniae and Klebsiella oxytoca isolated from backyard broiler chickens and their contacts with antimicrobial resistance genes of Klebsiella pneumoniae.
The study identified multiple antimicrobial resistance genes in Klebsiella pneumoniae and Klebsiella oxytoca isolates from backyard broiler chickens and human contacts, including ermB, blaTEM, blaCTX-M1, sul1, tetA, gyrA, blaOXA-48, and mcr-1, indicating widespread multidrug resistance.
Nanopore targeted sequencing in lower respiratory infections: a retrospective study on diagnostic applications, clinical characterization, and antimicrobial guidance.
The study identified 16 distinct AMR genes in 15 patients using NTS, highlighting the effectiveness of NTS in detecting resistance genes in ESKAPE pathogens.
Characterization of Enterobacter cloacae complex clinical isolates: comparative genomics and the role of the efflux pump AcrAB-TolC over-expression and NDM-1 production.
The study characterizes carbapenem-resistant Enterobacter cloacae complex isolates, highlighting the roles of the AcrAB-TolC efflux pump over-expression and the bla NDM-1 carbapenemase in conferring resistance. Multiple resistance genes, including bla NDM-1, acrAB-tolC, and various beta-lactamases, aminoglycoside-modifying enzymes, and sulfonamide resistance genes, were identified and validated.
Global geographic and genomic epidemiology analysis of carbapenem-resistant Escherichia coli carrying bla(NDM-9).
The study characterizes bla NDM-9 -carrying carbapenem-resistant Escherichia coli (CREC) and identifies various antibiotic resistance genes (ARGs) contributing to multidrug resistance. It highlights the role of mobile genetic elements in the dissemination of bla NDM-9 and emphasizes the importance of surveillance for these high-risk clones.
Genomic characterisation of multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from various sources in Algeria, North Africa.
The study identified multiple AMR genes and chromosomal mutations in multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from Algeria, including bla TEM-1B, bla CTX-M-15, aac(3)-Id, aadA7, sul1, tet(A), mph(A), qnrB19, cmlA1, and floR, along with mutations in gyrA and parC genes that confer resistance to ciprofloxacin.
Genetic insights into antimicrobial resistance and virulence characteristics of Salmonella enterica isolated from Nile tilapia sourced from retail markets in Thailand.
The study identified multiple antimicrobial resistance (AMR) genes in Salmonella enterica isolates from Nile tilapia, including beta-lactamases (bla TEM−1B, bla CTX−M−55, bla CTX−M−14, bla LAP−2), quinolone resistance genes (qnrS1, qnrS13), tetracycline resistance genes (tet(A), tet(B), tet(M)), aminoglycoside resistance genes (aadA2, aph(3’’)-Ib, aph(6)-Id, aac(6’)-Ia), sulfonamide resistance genes (sul1, sul2, sul3), florfenicol resistance gene (floR), and efflux pump systems (mdsABC, mdtK).
An integrated phenotypic and genomic approach to characterize MBL-producing Enterobacterales strains circulating in a Sicilian transplant center.
The study characterizes MBL-producing Enterobacterales strains, identifying NDM-1, NDM-5, and VIM-1 as the most prevalent metallo-beta-lactamases. It also identifies various aminoglycoside, quinolone, and sulfonamide resistance genes, highlighting the multidrug-resistant nature of these isolates.
City or Suburb, Resistance Flows: Wastewater-Borne ESKAPE and AMR Genes in Malaysian Hospitals.
The study identified several AMR genes, including ermB, VanA, BlaTEM, tetA, Sul1, and BlaNDM-1, in ESKAPE pathogens from hospital wastewater in Klang Valley and suburban areas of Malaysia. These genes were associated with resistance to various antibiotics, highlighting the significance of hospital wastewater as a reservoir for AMR genes.
Integrated Analysis of Salmonella Infantis in Chicken Meat: Epidemiological Surveillance, Antibiotic Resistance, and Potential Bioactive Control Agents.
The study identified multiple antibiotic resistance genes in Salmonella Infantis isolates from chicken meat, including blaTEM-1, aadA1, aphA1-IAB, and sul1, indicating multidrug resistance. Carvacrol showed the strongest antimicrobial activity against these isolates.
Global emergence of Acinetobacter baumannii International Clone 12 predominantly found in the Middle East.
The study identifies multiple acquired antimicrobial resistance genes in Acinetobacter baumannii International Clone 12, including bla OXA-23, bla GES-11, bla GES-12, bla GES-22, bla GES-35, bla CARB-16, bla CARB-49, aphA6a, aadB, strA, strB, cmlA1, aadA2b, sul1, drfA7, dfrA1, qacE, tet(B), tet(X3), msr(E), mph(E), bla TEM-1B, and aacC3. These genes contribute to resistance against various antibiotics, highlighting the complexity of resistance mechanisms in this clone.
Genomic characterization of two distinct Klebsiella pneumoniae strains in a fatal case of relapsed acute myelogenous leukemia: a case report.
The study identified two distinct Klebsiella pneumoniae strains, ST147 and ST967, with varying resistance profiles. ST147 isolates harbored multiple resistance genes including bla OXA−181, aadA, aadA5, bla CTX−M−15, bla OXA−1, bla SHV−11, bla TEM−1, sul1, qnrS1, and tet(A), while ST967 had a more limited resistome with aac(3)-IIa, bla SHV−27, and dfrA14.
Antibiotic susceptibility patterns of clinical isolates of salmonella species producing extended spectrum beta lactamases as predictor of multidrug resistance in a tertiary hospital, Southeastern Nigeria.
The study identified blaTEM, tetA, and sul1 as the most prevalent resistance genes in Salmonella isolates, which are associated with multidrug resistance and extended-spectrum beta-lactamase production.
Multidrug Resistance and Virulence Gene Profiles of E. coli in Broiler Chickens: A Study From Noakhali, Bangladesh.
The study identified high levels of multidrug resistance (MDR) in E. coli isolates from broiler chickens and environmental samples in Bangladesh, with a significant prevalence of virulence genes such as iroN, ompT, hlyF, iss, and iutA.
Genomic diversity and antimicrobial resistance of Vibrio cholerae isolates from Africa: a PulseNet Africa initiative using nanopore sequencing to enhance genomic surveillance.
The study identified a high prevalence of trimethoprim resistance genes (dfrA1, dfrA15, dfrA31) and other resistance genes such as floR, strA, strB, varG, blaCARB-2, aadA1, aadA2, sul1, sul2, catB9, tet(C), tet(G), tet(59), qacEdelta, and blaCMY-4 in Vibrio cholerae isolates from Africa. Fluoroquinolone resistance mutations (gyrA_S83I and parC_S85L) and nitrofuran resistance mutations (nfsA_R169C and nfsB_Q5*) were also prevalent.
Genomic Characterization and Resistance Mechanisms of Carbapenem-Resistant Klebsiella pneumoniae ST101 Isolates from Saudi Arabia.
The study identifies bla_OXA-48 and bla_NDM-1 carbapenemase genes in CRKP ST101 isolates from Saudi Arabia, highlighting their role in carbapenem resistance and the complexity of resistance mechanisms in high-risk clones.
Genomic analysis of multidrug-resistant Salmonellaenterica Serovar Montevideo isolates in China.
The study identified multiple AMR genes in Chinese S. Montevideo isolates, including beta-lactamases (bla TEM−1B, bla OXA−1, bla LAP−2, bla CTX−M−55, bla CTX−M−65, bla DHA−1), quinolone resistance genes (qnrS2, qnrS1, qnrA1, qnrB6, qnrB4, qepA1), macrolide resistance genes (mphA, mphE, msrE, mphB), tetracycline resistance genes (tetA, tetD, tetB), sulfonamide resistance genes (sul1, sul2, dfrA14, dfrA12, dfrA27, sul3), and chloramphenicol resistance genes (floR, catA2, catB3).
Precise species identification and whole-genome sequencing analysis of Enterobacter cloacae complex causing bloodstream infections in China.
The study identified various AMR genes in Enterobacter cloacae complex (ECC) isolates, including bla ACT, bla NDM, and mcr-10, which confer resistance to beta-lactams, carbapenems, and polymyxins, respectively. It also found that E. roggenkampii was the most common species among carbapenem-resistant isolates and showed high resistance to both carbapenems and colistin.
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
Comparative genomics reveals avian Acinetobacter baumannii as antimicrobial resistance reservoirs and bovine strains with elevated pathogenicity.
Avian Acinetobacter baumannii strains were found to carry a significantly higher number of antimicrobial resistance genes compared to bovine and porcine strains, highlighting their potential role in the dissemination of antimicrobial resistance through animal origin foods.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Antibiotic contamination and antimicrobial resistance dynamics in the urban sewage microbiome in India.
The study identifies multiple antibiotic resistance genes (ARGs) in urban sewage samples from India, highlighting the presence of genes such as blaTEM, catB, aac(6')-Ib, sul1, ermB, dfrA1, mphA, sul2, blaOXA, blaCTX-M, and qnrS, which confer resistance to various antibiotic classes.
Detection and Preliminary Genomic Characterization of Poultry-Derived Salmonella enterica from Southern Kazakhstan.
The study identified multidrug-resistant Salmonella enterica isolates from poultry farms in southern Kazakhstan, with universal fluoroquinolone resistance and plasmid-borne AMR genes such as blaTEM-116, tet(A), sul1, ant(3")-Ia, and dfrA14.
Unveiling Equine Abortion Pathogens: A One Health Perspective on Prevalence and Resistance in Northwest China.
The study identified multiple antibiotic resistance genes in equine abortion pathogens, including CTX-M, TEM-1, TetM, ermA/B/C, qnrA/B, sul1/2, dfrA1/5, SHV, OXA-1, OXA-23/48/58, mecA/B/C, IMP-1/2, NDM-1, VIM-1/2, and vanA/B/C, highlighting the widespread resistance to various antibiotics among these pathogens.
Bloodstream infection with NDM-1/5 Enterobacter cloacae complex in China: diverse STs, multi-virulence systems and carbapenem resistance.
The study identifies blaNDM-1 and blaNDM-5 as the primary carbapenemases in CRECC isolates, along with additional resistance genes such as aac(6')-Ib-cr, aac(3)-II, qnrB1, qnrA1, sul1, and mcr-9.
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