Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
sulfonamide-resistant dihydropteroate synthase Sul2
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Sul2 | Reference Gene CatalogResFinder DatabaseReslit | 924 | SULFAMETHOXAZOLE, SULFONAMIDE +13 | Salmonella enterica subsp. enterica serovar Choleraesuis +296 | United Kingdom|Kenya, Germany, Europe, Sweden, Peru|Bolivia, Madrid, Spain, Taiwan, Bolivia, Japan|United States, United States|Shipyard Creek, United Kingdom, United States|Madagascar|Japan, Spain, Canada, Italy|Denmark|United Kingdom, South Africa, India|Sweden, Asia|Africa|Europe|South America|Global, Ireland, Tunisia, Global, Haiti, Japan, Switzerland|Lausanne, Switzerland, US, Berlin, Germany, Nigeria, Portugal, Madagascar, Metro-Manila, Philippines, China|Beijing, China, Brazil, Ankara, Turkey, Bangladesh, Baltic Sea|Finland, USA|Brazil|United States, coastal aquaculture site in Japan|marine environment, United States, Brazil|China|Hong Kong|Indonesia|Israel|Nigeria|Peru|Singapore|Thailand|Vietnam, Zambia, Nebraska|United States, Jiangsu Province, Southeastern China, India, South West London, UK, Okinawa Prefecture, Japan, Nepal, Japan|Thailand|Canada|France|Spain|South Korea|United Kingdom|Croatia|Vietnam|global, Peru, Denmark|Taiwan|South Korea|Africa|Asia|Europe|North America|Canada|Norway|South Africa|United States, Germany|Denmark|Sweden|France|Italy, China, poultry, Denmark, Europe|Italy, Texas|Nebraska|Alberta|France|Alberta, Canada|Nebraska, Texas, USA|Nantes, France, Latin America, Europe|Portugal, Nepal|Japan, North America, United States|New York|Florida|Illinois|Gaza|Colombia|South America|Mediterranean region, Tanzania, South Korea, Norway, Germany|France|Netherlands|Belgium, Europe|Australia|United Kingdom|Netherlands|Greece|US|UK, New York|Washington, San Francisco|Seattle|Minnesota|Minneapolis|Sacramento|Dallas|Jackson, Kenya, North Carolina, Australia, USA|Australia|Canada|Japan|France|Madagascar|China|Thailand|Germany, Europe|seafood, Cambodia, human|mouse|pig, Guangxi, China, Pakistan, France, Alberta, West Africa|Conakry, Guinea, Cameroon, UK|Latin America, Chile, Ghana, Japan|aquaculture, Scotland, Maryland|District of Columbia, Global|global, Germany|Vietnam|Egypt, Australia|US|UK, United Kingdom|Brazil, Bangladesh|Pakistan|Nepal, Gothenburg, Africa|Ghana|Kenya|Tanzania, St. Louis, MO, USA, Italy, La Paz, Bolivia|La Paz River basin, Australia|Denmark, Mexico, Denmark|France|Poland|Italy|Hungary|Germany|Estonia|United States, China|Brazil|United Kingdom|Denmark, developing countries, Jordan, Ecuador, Pakistan|Denmark, UK, Southeastern Brazil, Taiwan|Germany|Netherlands|United Kingdom|United States, Utah, Northern Thailand, Amazon River|Kalamas River|Cam River|Cambridge|Amazon River Plume, Shandong province, China, Southern China, Vermont|United States, Malawi, Greece, Korea, Germany|global, Egypt, Lake Victoria, Tanzania, Belgium, Portugal|Spain|France, Vietnam, H1 Hospital, Iran, northern Xinjiang, China|China, Tuscany, Black Sea, Madagascar|Cambodia|Senegal, Philippines, Czech Republic, California|Arizona|South Carolina|Idaho|Maine, China|USA|Italy|Israel, Shanghai, China, Thailand, Argentina, USA, Italy|Colombia|United States|South Africa|India|Greece|North Africa, Switzerland, South Africa|various water sources, USA|Peru|Egypt|Cambodia|Kenya, Brazilian Amazon, Vietnam|China, Thailand|Nepal, Karnataka, Southern India, Europe|Netherlands, Denmark|Finland|Iceland|Lithuania|Netherlands|Spain, Kenya|Malawi, Uruguay, USA|Brazil|Japan|Thailand|Pakistan, Russia, Guadeloupe|French West Indies, Yellow Sea, Armenia|Georgia, Pacific region|Hawaii, Singapore, Malaysia, Europe|Canada, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, England, Tokyo, Japan|Japan, Italy|Europe, North America|Asia|Europe|Australia|South America, Europe|Spain|Hungary|Germany|France|Belgium|Poland|United Kingdom|Denmark, Beijing, China|China, Ontario, Canada|North America, Europe|Germany, India|Pakistan|Bangladesh|Philippines|Democratic Republic of the Congo, Europe|United States, Portugal|Porto, Vietnam|Southeast Asia, California|Europe|North America|Republic of Congo, Chengdu, China, Romania|Spain, Slovakia, India|Malaysia|South China, sub-Saharan Africa|Burkina Faso|Ghana|Guinea-Bissau|Kenya|Senegal, United Kingdom|England|Australia, Poland, Colombia, East Coast Peninsular Malaysia, New York State, Africa|Gambia, North Carolina|USA, Quebec|Ontario|France|Switzerland, Afghanistan, Victoria, Australia, Uganda|Kenya, Benin, Zhanjiang, China, Lebanon|India|Spain|UK|USA|Morocco|Germany|Tunisia|Egypt|France|Turkey|Libya|Mexico|Italy|South Korea, India|United States, Caribbean, Europe|Greece, Finland|Eastern Finland, Spain|Asturias, Northern Spain, Europe|Asia, USA|France|Finland|Lebanon|Alabama, Mecklenburg-Western Pomerania, China|Bangladesh|USA|England|India, The Gambia, Senegal, Europe|North America|Netherlands|Denmark|Pennsylvania|United States|France, Kuwait, North-Western Mexico, Guangxi Province, New South Wales, Australia, Guizhou Province, China, central Adriatic Sea|Croatia|Croatian marine environment, Algeria, Sudan, Germany|Colombia|Vietnam|Japan|Nicaragua|United States|Canada|Brazil|Thailand|Lebanon|Poland|France|Italy|Spain|Portugal|Mexico|China|South Korea|India, Australia|Melbourne, Australia, North America|Asia|Europe|Middle East|Africa, China|France|Australia|Germany|USA|Netherlands|Japan|Cambodia|Thailand|Vietnam|India|Pakistan|Chile|Czech Republic|Colombia|China (bigeye tuna), Hungary, South America, Europe|USA|Portugal|Germany|Australia|China|India|Pakistan|Sweden|Colorado, Germany|Poland|Denmark, poultry farms in China, Hong Kong, Ningxia, China|China, South Australia|Australia, New Zealand, Abuja, Nigeria, Henan|Hubei|Hunan|Anhui|Jiangxi|Shaanxi|Shanxi, Democratic Republic of Congo|Democratic Republic of the Congo, northwest China, Turkey, North Sea|Baltic Sea, South America|Chile, South America|Australia|France|Vietnam|China, Guadeloupe, Italy|Taiwan|Spain|China|Australia|United States|Egypt|Bolivia, Egypt|United States|China, Zhejiang, China|China, Al-Kharj, KSA, La Paz River basin, Bolivia|La Paz River basin, Burkina Faso, Yangzhou, China, Zagreb, Croatia|Zagreb|Croatia, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Ontario, Canada, Shijiazhuang, Hebei Province, Holtemme river, Saxony-Anhalt, Germany, Oxfordshire, UK, Midwestern U.S.|Nebraska, Anhui, China, Saudi Arabia, Finland, Norway|Kenya|United Kingdom|Italy, Western Africa|Mali, United Kingdom|High-risk countries, Northwest, China|Northwest China, Maryland|California|New York|Pennsylvania, southwestern Siberia, Ethiopia|USA|Israel|Turkey|United Kingdom|France|Belgium|Denmark|Czechia, Lebanon, Wenzhou, China, Pakistan|Karachi, Pakistan, West Texas, USA, Alexandria, Egypt, Sichuan|Heilongjiang|Anhui|MY|LA|DQ, New Orleans metropolitan area, Shenzhen, China|China, Northern Italy, Moscow, Russia, East China, Wales|Nigeria, Lake Michigan|United States|North America, China|Bolivia|United States|Canada|New Zealand, Mozambique, Australia|South Australia, Tamaulipas, Mexico, Croatia, Central Greece, Brazilian Amazon Region, Salish Sea, Uganda, Central Adriatic|Central Adriatic Sea, Tennessee, USA|East Tennessee, Germany|Australia|Taiwan|USA|Canada|Denmark, Côte d'Ivoire|West Africa, France|South America|Europe|Asia|North Africa, USA|Honduras|UK|Kenya, Danakil Depression, Afar Region, Ethiopia, Europe|United States|Asia|Africa|Australia|Bangladesh, Europe|Asia|North America, Peruvian Amazon, Quebec, Canada, Iraq, Europe|America|Africa, Northern Spain, Bangkok, Thailand, Slovak Republic, Alicante city, Hebei Province|China|Hebei Province, China, Canada|France|Germany|North America|Europe, Zanzibar, Guangdong Province, China, California, Jiangsu Province|China, Baton Rouge, LA, Accra, Ghana|Ghana, France|Ecuador|Vietnam|India|Madagascar|Nigeria, Saskatchewan, Fiji, Virginia|Illinois, Bulgaria, Uruguay|Chile, Inner Mongolian, Switzerland|Europe, Edo State, Nigeria, Ethiopia, Indonesia|Australia, Europe|Russia, Portugal|various regions, Asia|South America|North America|Europe|Africa, Pakistan|China|United States|United Kingdom|Canada|Australia|Spain|Denmark|UAE|Ethiopia|India|South Asia, Rwanda, Fujian Province, Southeast China|China, Vancouver, Canada, Romania, France|Germany|Netherlands|Norway|Spain|United Kingdom|Europe, Shenzhen|Dapeng, Europe|Czech Republic, Armenia, Austria, Somali region, Ethiopia|Somali Region, Ethiopia, Zimbabwe, Kentucky|USA, Shanghai, China|China, Terengganu, Malaysia|Malaysia, Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom, Israel, Calabria|Italy, mariculture areas, Iowa, United States, China|Anhui|Hainan|Sichuan, Indonesia|USA|China|Europe|Finland, Indonesia, Sri Lanka, New Mexico, USA, Asia|North America|Australia|South America, Guangzhou, China, Greater Accra Region, Ghana|Ghana, Kano, Nigeria|Nigeria, Shanghai|Minhang District, United Arab Emirates, Western Balkans|Hungary, Costa Rica, Paraguay, China|Lebanon|United States|Poland|France, Hebei, China|Hebei province, China, Argentina|Brazil|USA|Germany|Chile|Czech Republic|Hungary|Spain|Turkey|Afghanistan|Ukraine, North Carolina, USA, Shandong Province|adjacent regions in China, China|Europe|Americas|Asia|North Africa|Middle East, Wuhan, China|Shenzhen, China, Norway|Sweden, Paraguay|Northern Spain, Europe|Croatia, Germany|Spain|UK|Vietnam, China|North America|Asia|Europe|Africa|Other, Pakistan|UK, Europe|Poland, Northern Nigeria|Nigeria, USA|China|Spain|Australia|Japan|Switzerland|Netherlands|Brazil|Taiwan|New Hampshire, USA|global, Europe|Norway|Romania, southwestern Nigeria, Peninsular Malaysia|Malaysia, Shenzhen, China, Australia|France|Bangladesh|United States, Sichuan, China, Europe|China, East Africa|Tanzania|Uganda, Madagascar|Cambodia, Asia|China, Southern Togo|Togo, Egypt|Northern Egyptian governorates of Kafr El-Sheikh and Dakahlia, Africa, northwest China|China | 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AB366440.1 | BAF92949.1 |
| sul2 | Card DatabaseResFinder Database | 2 | SULFAMETHOXAZOLE | Vibrio cholerae +1 | - | 2006 | AY055428.1 | AAL59753.1 |
| sul 2 | Reslit | 33 | sulfamethoxazole, sulfonamides +1 | Salmonella enterica +23 | South Africa|Brazil, South Africa, northern Xinjiang, China|China, Colombia|USA, United States|Virginia, Colombia, Vietnam, Guangdong Province, Europe, Bangkok, Thailand, Edo state, Nigeria, Eastern Cape province, South Africa|South Africa, Italy, Southeast Nigeria, Denmark, Edo State, Nigeria, Lake Michigan|United States|North America, Germany, Portugal, Shandong, China, Bangladesh, Egypt, Guadeloupe, Quebec|Shenzhen Bay, France|Hungary, Egypt|Northern Egyptian governorates of Kafr El-Sheikh and Dakahlia, India|China|Brazil | 2016, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | CP012043|NXKY01000005.1 | - |
| sul-2 | Reslit | 1 | trimethoprim sulfamethoxazole | Salmonella enterica serovar Senftenberg | India | 2019 | PRJNA483094 | - |
| sul(2) | Reslit | 1 | sulfamethoxazole | Actinobacillus pleuropneumoniae | Taiwan | 2024 | PRJNA1045321|PRJNA1045325 | - |
| sul -2 | Reslit | 1 | sulfamethoxazole | Escherichia coli | Bangladesh | 2024 | - | - |
Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constins.
Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constins.
Nucleotide sequence and organization of plasmid pMVSCS1 from Mannheimia varigena: identification of a multiresistance gene cluster.
Nucleotide sequence and organization of plasmid pMVSCS1 from Mannheimia varigena: identification of a multiresistance gene cluster.
Sulfonamide Resistance in Haemophilus influenzae Mediated by Acquisition of sul2 or a Short Insertion in Chromosomal folP
The study identifies two mechanisms of sulfonamide resistance in Haemophilus influenzae: acquisition of the sul2 gene and a 15-bp insertion in the chromosomal folP gene.
New plasmid-borne antibiotic resistance gene cluster in Pasteurella multocida.
The study identifies a novel plasmid-borne antibiotic resistance gene cluster in Pasteurella multocida, including sul2 for sulfonamide resistance, strA and strB for streptomycin resistance, and tet(H) for tetracycline resistance.
New plasmid-borne antibiotic resistance gene cluster in Pasteurella multocida.
New plasmid-borne antibiotic resistance gene cluster in Pasteurella multocida.
Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins.
Cats as a risk for transmission of antimicrobial drug-resistant Salmonella.
The study identified several antimicrobial resistance genes in Salmonella isolates from cats, including blaTEM, cat, sul2, tet(A), and dfrA1, which confer resistance to ampicillin, chloramphenicol, sulfonamides, tetracycline, and trimethoprim, respectively.
Integrons and gene cassettes in clinical isolates of co-trimoxazole-resistant Gram-negative bacteria.
The study identified a new dfr gene, dfrA22, in a class 1 integron, which contributes to trimethoprim resistance in co-trimoxazole-resistant Gram-negative bacteria.
Plasmid-mediated florfenicol resistance in Pasteurella trehalosi.
Plasmid-mediated florfenicol resistance in Pasteurella trehalosi.
Multidrug-resistant commensal Escherichia coli in children, Peru and Bolivia.
The study identified multiple multidrug-resistant commensal E. coli isolates in children from Peru and Bolivia, highlighting the prevalence of resistance genes such as blaTEM, tet(A), tet(B), dfrA8, sul1, sul2, and catI.
Spread of Escherichia coli Strains with High-Level Cefotaxime and Ceftazidime Resistance between the Community, Long-Term Care Facilities, and Hospital Institutions.
The study identifies the spread of Escherichia coli strains with high-level resistance to cefotaxime and ceftazidime, primarily due to the presence of extended-spectrum beta-lactamases (ESBLs) such as CTX-M-15, CTX-M-14, and CTX-M-32. Additionally, other resistance genes like tetA, dfrA14, dfrA17, sul1, sul2, aac(6')Ib, and aac(3)IIb were found to contribute to multidrug resistance.
Complete nucleotide sequence of pK245, a 98-kilobase plasmid conferring quinolone resistance and extended-spectrum-beta-lactamase activity in a clinical Klebsiella pneumoniae isolate.
The study identifies the plasmid pK245 carrying the qnrS quinolone resistance gene and the blaSHV-2 extended-spectrum beta-lactamase gene, along with other resistance genes such as aacC2, strA, strB, catA2, sul2, tetD, and dfrA14, which confer resistance to multiple antimicrobial classes in Klebsiella pneumoniae.
Population structure and resistance genes in antibiotic-resistant bacteria from a remote community with minimal antibiotic exposure.
The study identified various acquired antibiotic resistance genes in commensal E. coli isolates from a remote community with minimal antibiotic exposure, including blaTEM, catI, cmlA6, tet(A), tet(B), dfrA1, dfrA7, dfrA8, dfrA17, sul1, sul2, aphA1, aadA1, aadA2, aadA5, aadB, and sat-1. These genes were found to be similar to those seen in antibiotic-exposed settings, indicating the dissemination of resistant bacteria and resistance genes from such environments.
Complete DNA sequence and analysis of the transferable multiple-drug resistance plasmids (R Plasmids) from Photobacterium damselae subsp. piscicida isolates collected in Japan and the United States.
The study characterizes multiple-drug resistance plasmids from Photobacterium damselae subsp. piscicida, identifying genes conferring resistance to kanamycin, chloramphenicol, tetracycline, sulfonamide, and trimethoprim.
Small multidrug resistance plasmids in Actinobacillus porcitonsillarum.
Small multidrug resistance plasmids in Actinobacillus porcitonsillarum.
Small multidrug resistance plasmids in Actinobacillus porcitonsillarum.
Small multidrug resistance plasmids in Actinobacillus porcitonsillarum.
Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5
The study identifies multiple AMR genes and mutations in the multidrug-resistant E. coli isolate SMS-3-5, including beta-lactamase blaT, aminoglycoside resistance genes aadA and aph, sulfonamide resistance gene sul2, trimethoprim resistance gene dhfrV, chloramphenicol resistance gene cmlA, tetracycline resistance gene tetRA, and quinolone resistance mutations in gyrA and parC.
Diversity and distribution of commensal fecal Escherichia coli bacteria in beef cattle administered selected subtherapeutic antimicrobials in a feedlot setting.
The study identified bla TEM1, tet (A), and sul2 as prevalent resistance genes in commensal E. coli from beef cattle, highlighting the impact of antimicrobial use on resistance dissemination.
Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom.
The study identified the prevalence of sulfonamide resistance genes sul1, sul2, and sul3 in bacterial isolates from manured agricultural soils and pig slurry in the UK, highlighting their distribution and potential environmental impact.
Comparative genomics of the IncA/C multidrug resistance plasmid family.
The study identifies and characterizes the IncA/C multidrug resistance plasmid family, highlighting the presence of resistance genes such as sul2 for sulfonamides, tetRA for tetracyclines, and hipAB for antimicrobial resistance mechanisms.
Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids.
The study identifies several AMR genes, including bla ROB-1, tet(B), tet(H), tet(O), strA, and sul2, which are responsible for multidrug resistance in Pasteurella multocida. These genes are located on small plasmids and contribute to resistance against beta-lactams, tetracyclines, streptomycin, and sulfamethoxazole.
Longitudinal characterization of resistant Escherichia coli in fecal deposits from cattle fed subtherapeutic levels of antimicrobials.
The study identified several AMR genes, including blaTEM1, tetA, tetB, tetC, sul1, and sul2, in Escherichia coli from cattle fecal deposits. These genes conferred resistance to ampicillin, tetracycline, and sulfonamides.
Antimicrobial resistances do not affect colonization parameters of intestinal E. coli in a small piglet group.
The study identified various AMR genes in commensal E. coli from pigs, including blaTEM, catA1, aph(3')-Ia, aadA, strA/strB, tet(A), tet(B), sul1, sul2, and sul3. These genes conferred resistance to antibiotics such as ampicillin, chloramphenicol, kanamycin, neomycin, streptomycin, spectinomycin, tetracycline, and sulfamethoxazole. However, the presence of these resistance genes did not provide a significant colonization advantage or disadvantage in the pig intestine.
Evidence for a second genomic island conferring multidrug resistance in a clonal group of strains of Salmonella enterica serovar Typhimurium and its monophasic variant circulating in Italy, Denmark, and the United Kingdom.
The study identifies the resistance genes bla TEM-1, strA-strB, sul2, and tet(B) in multidrug-resistant Salmonella enterica serovar Typhimurium and its monophasic variant strains, which are chromosomally located and confer resistance to ampicillin, streptomycin, sulfonamides, and tetracycline.
Antibiotic susceptibility profiles of some Vibrio strains isolated from wastewater final effluents in a rural community of the Eastern Cape Province of South Africa.
The study identified several antibiotic resistance genes in Vibrio strains isolated from wastewater effluents, including dfrA1, dfr18, floR, sul2, strB, and tetA, which confer resistance to trimethoprim, chloramphenicol, sulfamethoxazole, streptomycin, and tetracycline.
Pork contaminated with Salmonella enterica serovar 4,[5],12:i:-, an emerging health risk for humans.
The study identified the genes bla TEM1-like, sul2, strA-strB, and tet(B) as responsible for multidrug resistance to ampicillin, sulfamethoxazole, streptomycin, and tetracycline in Salmonella enterica serovar 4,[5],12:i:-.
Pyrosequencing of antibiotic-contaminated river sediments reveals high levels of resistance and gene transfer elements.
The study identifies high levels of resistance genes, including sul2, strA, strB, and qnrD, in river sediments contaminated with antibiotics, highlighting the role of environmental microbial communities in the dissemination of antibiotic resistance.
Emergence of a globally dominant IncHI1 plasmid type associated with multiple drug resistant typhoid.
The study identifies the emergence of a globally dominant IncHI1 plasmid type (PST6) associated with multiple drug-resistant typhoid. Key resistance genes include blaTEM-1, cat, dfrA7, sul1, sul2, strAB, tetA, tetD, and betU, which contribute to resistance against ampicillin, chloramphenicol, trimethoprim, sulfamethoxazole, streptomycin, tetracycline, and high salt environments.
Acquired antibiotic resistance: are we born with it?
The study identified the presence of tetracycline resistance gene tet (M), erythromycin resistance gene ermB, sulfonamide resistance gene sul2, and beta-lactam resistance gene bla TEM in the gut microbiota of infants, indicating that antibiotic resistance genes are present in the human gut microbiota from an early age.
Characterization of multidrug-resistant Escherichia coli isolates from animals presenting at a university veterinary hospital.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from animals, including bla TEM, bla CTX-M-2, bla CMY-2, strA-strB, aadA, aphA1, aadB, cat, floR, sul1, sul2, tet(A), and tet(B). These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, sulfonamides, and tetracyclines.
Molecular characterization of multidrug-resistant Escherichia coli isolates from Irish cattle farms.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from Irish cattle farms, including strA-strB, aphA1, aadA, aadB, blaTEM, sul2, tet(A), and tet(B). These genes were associated with resistance to streptomycin, neomycin, kanamycin, spectinomycin, ampicillin, amoxicillin-clavulanic acid, sulfonamides, and tetracycline.
Phenotypic and genotypic characterization of Salmonella enterica recovered from poultry meat in Tunisia and identification of new genetic traits.
The study identified various AMR genes in Salmonella enterica isolates from poultry meat in Tunisia, including blaTEM, aadA1, aadA2, dfrA1, sul1, sul2, sul3, strA-strB, cmlA, and tet(A). These genes contribute to resistance against multiple antibiotics such as ampicillin, sulfonamides, streptomycin, trimethoprim, chloramphenicol, and tetracycline.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Drug-resistance mechanisms in Vibrio cholerae O1 outbreak strain, Haiti, 2010.
The study identified resistance genes strA, strB, sul2, dfrA1, and floR in the Haiti V. cholerae O1 outbreak strain, along with mutations in gyrA (Ser83Ile) and parC (Ser85Leu) contributing to quinolone resistance.
Novel conjugative transferable multiple drug resistance plasmid pAQU1 from Photobacterium damselae subsp. damselae isolated from marine aquaculture environment.
The study identifies several AMR genes on the plasmid pAQU1, including bla CARB-9 -like, floR, mef (A)-like, sul2, tet (M), and tet (B), which confer resistance to various antibiotics such as carbenicillin, chloramphenicol, florfenicol, erythromycin, sulfonamide, and tetracycline.
Increased levels of multiresistant bacteria and resistance genes after wastewater treatment and their dissemination into lake geneva, Switzerland.
The study identified the presence of sulfonamide resistance genes sul1 and sul2 in wastewater and lake samples, indicating the spread of multidrug-resistant bacteria after wastewater treatment.
Identification of novel genomic islands and transposons encoding genes that may contribute to host specificity and Salmonella transmission
The study identified various antibiotic resistance genes in Salmonella plasmids, including beta-lactamases (bla CTX, bla CMY, bla TEM), aminoglycoside resistance genes (aadA1, aadA2, strA, strB), tetracycline resistance gene (tetA), chloramphenicol resistance gene (cmlA), sulfonamide resistance gene (sul2), and genes conferring resistance to heavy metals and disinfectants (sugE, arsR, cusR, silE, qacH).
Frequent combination of antimicrobial multiresistance and extraintestinal pathogenicity in Escherichia coli isolates from urban rats (Rattus norvegicus) in Berlin, Germany.
The study identified multidrug-resistant Escherichia coli strains in urban rats, including an ESBL-producing strain (IMT20717) carrying bla CTX-M-9, bla TEM-1-like, sul2, strA, strB, aac(6′)-Ib-cr, and aadA. These strains exhibited resistance to multiple antimicrobial classes, including beta-lactams, aminoglycosides, and fluoroquinolones.
DNA sequence analysis of plasmids from multidrug resistant Salmonella enterica serotype Heidelberg isolates.
The study identified multiple antimicrobial resistance genes in plasmids from multidrug-resistant Salmonella enterica serotype Heidelberg isolates, including bla CMY, aadA, aadB, aphA, strA, strB, sul1, sul2, tetA, floR, cmlA, dfrA1, dfrA12, and aacC.
Cholera outbreaks in Nigeria are associated with multidrug resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae.
The study identifies multidrug-resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae strains in Nigeria, highlighting the presence of resistance genes such as floR, sul2, dfrA1, and strAB, along with quinolone resistance mutations in gyrA (Ser83Ile) and parC (Ser85Leu).
Commensal Enterobacteriaceae as reservoirs of extended-spectrum beta-lactamases, integrons, and sul genes in Portugal.
The study identifies blaCTX-M-14 and blaTEM-153 as extended-spectrum beta-lactamases in commensal Enterobacteriaceae in Portugal, along with sul1, sul2, and sul3 as sulfonamide resistance genes. These genes are part of mobile genetic elements such as integrons and plasmids, highlighting the role of commensal flora as a reservoir of clinically relevant antibiotic resistance genes.
Molecular characterization of multidrug-resistant extended-spectrum β-lactamase-producing Enterobacteriaceae isolated in Antananarivo, Madagascar.
The study identified bla CTX-M-15 and bla SHV-12 as the predominant ESBL genes in multidrug-resistant Enterobacteriaceae isolates in Antananarivo, along with other resistance genes such as aac(6')-Ib, tetA, sul1, sul2, qnrA, qnrB, and catB-3.
Who possesses drug resistance genes in the aquatic environment?: sulfamethoxazole (SMX) resistance genes among the bacterial community in water environment of Metro-Manila, Philippines.
The study identified sul1, sul2, and sul3 genes as the main sulfonamide resistance genes in the bacterial community of the aquatic environment in Metro-Manila, Philippines. Sul1 and sul2 were predominant in culturable bacteria, while sul3 was more prevalent in non-culturable marine bacteria.
Complete genome analysis of three Acinetobacter baumannii clinical isolates in China for insight into the diversification of drug resistance elements.
The study identifies multiple AMR genes and resistance islands in three multidrug-resistant Acinetobacter baumannii isolates, highlighting the role of genomic plasticity in the dissemination of resistance mechanisms.
Impact of manure fertilization on the abundance of antibiotic-resistant bacteria and frequency of detection of antibiotic resistance genes in soil and on vegetables at harvest.
The study identified several antibiotic resistance genes in soil and on vegetables, including genes conferring resistance to tetracycline, aminoglycosides, erythromycin, sulfamethoxazole, and beta-lactams. The presence of these genes was influenced by manure fertilization, with certain genes more frequently detected in manured soils.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
Characterization of class 1 integrons and antibiotic resistance genes in multidrug-resistant Salmonella enterica isolates from foodstuff and related sources.
The study identified several AMR genes, including aadA, sul1, sul2, tetA, blaTEM-1, and qacEAI, associated with resistance to streptomycin, sulfamethoxazole-trimethoprim, tetracycline, ampicillin, and quaternary ammonium compounds, respectively. A mutation in the gyrA gene (Ser83Phe) was linked to resistance to nalidixic acid and enrofloxacin.
Comparative genomics reveals that a fish pathogenic bacterium Edwardsiella tarda has acquired the locus of enterocyte effacement (LEE) through horizontal gene transfer.
The study identified a loss-of-function mutation in the esrB gene of the type III secretion system (T3SS) in the attenuated E. tarda strain E22, which is associated with reduced virulence. Additionally, the study discovered a LEE-like pathogenicity island (Et-LEE) in the non-motile strain FPC503, which was horizontally transferred and contains genes similar to those in pathogenic E. coli.
Characterization of antibiotic resistance in Salmonella enterica isolates determined from ready-to-eat (RTE) salad vegetables.
Four Salmonella enterica strains isolated from ready-to-eat salad vegetables exhibited resistance to sulfonamides, with sul1 and sul2 genes identified as the primary resistance mechanisms. The 55.0 kb plasmid of strain RTE-1 was found to encode these genes without involvement of integrons.
Plasmid-mediated sulfamethoxazole resistance encoded by the sul2 gene in the multidrug-resistant Shigella flexneri 2a isolated from patients with acute diarrhea in Dhaka, Bangladesh.
The study identifies the sul2 gene on a 4.3 MDa plasmid as the primary determinant of sulfamethoxazole resistance in multidrug-resistant Shigella flexneri 2a strains.
Diversity of plasmids encoding resistance and virulence functions in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variant 4,[5],12:i:- strains circulating in Europe.
The study identifies various AMR genes in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variant 4,[5],12:i:- strains, including aac(3)-IV, bla TEM-1, cmlA1, aadA1, aadA2, strA, sul1, sul2, sul3, tet(A), tet(B), and dfrA12, which confer resistance to multiple antibiotics.
Sulphonamide and trimethoprim resistance genes persist in sediments at Baltic Sea aquaculture farms but are not detected in the surrounding environment.
The study identified the persistence of sulphonamide resistance genes (sul1, sul2) and trimethoprim resistance gene (dfrA1) in sediments at Baltic Sea aquaculture farms, while these genes were not detected in the surrounding environment.
Comparative genomic analysis and virulence differences in closely related salmonella enterica serotype heidelberg isolates from humans, retail meats, and animals.
The study identified several AMR genes and mutations in Salmonella enterica serotype Heidelberg isolates, including bla, aac(6')-Ib, tet(M), qnrS1, and erm(B). Mutations in genes such as SEEHRA37_03221, SEEHRA37_24108, and others were associated with resistance traits.
Various pAQU plasmids possibly contribute to disseminate tetracycline resistance gene tet(M) among marine bacterial community.
The study identifies pAQU group plasmids that can transfer the tetracycline resistance gene tet(M) to E. coli, highlighting their potential role in spreading antibiotic resistance in marine environments.
Resistance determinants and mobile genetic elements of an NDM-1-encoding Klebsiella pneumoniae strain.
The study identifies multiple antibiotic resistance genes in the NDM-1-encoding Klebsiella pneumoniae strain, including eight beta-lactamase genes and various other resistance determinants, highlighting the complexity of its resistance profile.
Characterization of microbiota composition and presence of selected antibiotic resistance genes in carriage water of ornamental fish.
The study identified several antibiotic resistance genes including sul1, tet(A), strA, aadA, cat, tet(G), and sul2 in the microbiota of ornamental fish carriage water. These genes were found to be prevalent and associated with various bacterial families.
Complete proteome of a quinolone-resistant Salmonella Typhimurium phage type DT104B clinical strain.
The study identifies the aac(6')-Ib-cr4, strA, and sul2 genes as responsible for aminoglycoside, fluoroquinolone, and sulfonamide resistance in the quinolone-resistant Salmonella Typhimurium DT104B clinical strain Se20.
Genomic signature of multidrug-resistant Salmonella enterica serovar typhi isolates related to a massive outbreak in Zambia between 2010 and 2012.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant Salmonella enterica serovar Typhi isolates from Zambia, including strA, strB, blaTEM-1, sul1, sul2, dfrA7, and catA1. Mutations in the gyrA gene were also associated with fluoroquinolone resistance.
Occurrence of Antimicrobial-Resistant Escherichia coli and Salmonella enterica in the Beef Cattle Production and Processing Continuum.
The study identified several AMR genes in E. coli and Salmonella, including beta-lactamase genes (blaCMY, blaCTX-M), sulfonamide resistance genes (sul1, sul2, sul3), and dihydrofolate reductase genes (dfrA1, dfrA5, dfrA7, dfrA12). These genes conferred resistance to various antibiotics such as ampicillin, ceftiofur, ceftriaxone, and trimethoprim-sulfamethoxazole.
Sulfonamide-resistant bacteria and their resistance genes in soils fertilized with manures from Jiangsu Province, Southeastern China.
The study identified the presence of sul1, sul2, and sul3 genes in sulfonamide-resistant bacteria from manured soils in Jiangsu Province, China, highlighting their role in sulfonamide resistance and the potential risk to public health.
Phylogenetic distribution and prevalence of genes encoding class I Integrons and CTX-M-15 extended-spectrum β-lactamases in Escherichia coli isolates from healthy humans in Chandigarh, India.
The study identifies the presence of class 1 integrons and bla CTX-M-15 genes in commensal E. coli isolates from healthy individuals in Chandigarh, India. It also detects several gene cassettes conferring resistance to trimethoprim, streptomycin, spectinomycin, streptothricin, chloramphenicol, tetracycline, and sulfonamides.
Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India.
The study identified a diverse array of antibiotic resistance genes in a polluted lake in India, including sul2, qnrD, aph(6)-Id, aph(3′)-Ib, CMY2, qnrS, ant(3′)-Ia, dfrB1/dfrB5/dfrB6/dfrB8, GES, ere(A)/ere(C), qnrC, mph(E), dfrA1/dfrA15/dfrA25/dfrA30, erm(F), ant(2′)-Ia, cmlA, and tet(39). These genes conferred resistance to various classes of antibiotics, highlighting the significant presence of resistance mechanisms in the polluted environment.
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.
The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.
Resistance phenotypes and genotypes among multiple-antimicrobial-resistant Salmonella enterica subspecies enterica serovar Choleraesuis strains isolated between 2008 and 2012 from slaughter pigs in Okinawa Prefecture, Japan.
The study identified multiple antimicrobial resistance genes in Salmonella enterica subspecies enterica serovar Choleraesuis strains, including blaTEM, strA, strB, aadA1, aadA2, aphA1, aacC2, tetB, sul1, sul2, dhfrXII, and dhfrXIII. Additionally, mutations in the QRDRs of gyrA and parC were associated with quinolone resistance.
Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648.
The study identified bla CTX-M-15, aac (3)-IIa, aadA1, aadA2, aadA5, qnrB4, qnrS1, aac (6')-Ib-cr, bla OXA-1, bla TEM-1B, bla SHV-12, bla CMY-42, bla DHA-1, mphA, ermB, catA1, catB3, sul1, sul2, dfrA12, dfrA17, dfrA1, dfrA5, tetA, tetB, and tetD as key AMR genes in ESBL-producing E. coli isolates in Nepal, highlighting the prevalence of multidrug resistance.
Occurrence of bla CTX-M-1, qnrB1 and virulence genes in avian ESBL-producing Escherichia coli isolates from Tunisia.
The study identified blaCTX-M-1, qnrB1, tetA, tetB, sul1, sul2, and sul3 genes in avian ESBL-producing E. coli isolates from Tunisia, highlighting their role in resistance to beta-lactams, quinolones, and sulfonamides.
Outbreak of uncommon O4 non-agglutinating Salmonella typhimurium linked to minced pork, Saxony-Anhalt, Germany, January to April 2013.
The study identified the resistance genes blaTEM, strA-B, sul2, and tet(B) associated with the ASSuT phenotype in monophasic Salmonella Typhimurium DT193 strains. Additionally, 54% of the isolates showed resistance to chloramphenicol, although no specific chloramphenicol resistance genes were detected.
Insight into the mobilome of Aeromonas strains.
The study characterizes various antibiotic resistance genes (ARG) in Aeromonas strains, highlighting the presence of beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others. These genes are often located on plasmids and contribute to multidrug resistance.
Comparative analysis of antimicrobial resistance in enterotoxigenic Escherichia coli isolates from two paediatric cohort studies in Lima, Peru.
The study identified several AMR genes in ETEC isolates from Peruvian children, including bla TEM-like for ampicillin resistance, sul2 for sulfamethoxazole resistance, tet(A) and tet(B) for tetracycline resistance, and mph(A) for azithromycin resistance.
Mapping the Evolution of Hypervirulent Klebsiella pneumoniae.
The study identifies antibiotic resistance genes in hypervirulent Klebsiella pneumoniae isolates, highlighting the presence of SHV beta-lactamase and additional resistance genes in one isolate, CAS813, which exhibits resistance to multiple antibiotics.
Antimicrobial Susceptibility of Bordetella bronchiseptica Isolates from Swine and Companion Animals and Detection of Resistance Genes.
The study identified several AMR genes in Bordetella bronchiseptica isolates, including blaBOR-1, blaOXA, strA, strB, sul1, sul2, dfrA7, and tet(A). These genes confer resistance to various antibiotics such as ampicillin, streptomycin, trimethoprim/sulfamethoxazole, and tetracycline.
Housefly Larva Vermicomposting Efficiently Attenuates Antibiotic Resistance Genes in Swine Manure, with Concomitant Bacterial Population Changes.
The study found that housefly larva vermicomposting significantly reduces the abundance of tetracycline resistance genes (tet(M), tet(O), tet(Q), tet(W)) and increases the abundance of sulfonamide resistance genes (sul1, sul2) in swine manure. It also observed changes in the bacterial community structure, with a significant decrease in the diversity and richness of bacteria.
Draft Genome Sequence of a Pathogenic O86:H25 Sequence Type 57 Escherichia coli Strain Isolated from Poultry and Carrying 12 Acquired Antibiotic Resistance Genes.
The study reports the draft genome sequence of an E. coli strain carrying 12 acquired antibiotic resistance genes, including beta-lactamases, aminoglycoside modifying enzymes, sulfonamide resistance, trimethoprim resistance, tetracycline resistance, and streptothricin resistance.
Persistence of Multi-Drug Resistance Plasmids in Sterile Water under Very Low Concentrations of Tetracycline.
The study shows that multi-drug resistance plasmids pAQU1 and IncFIB can persist in bacterial populations under very low selective pressure, including in non-culturable states. The plasmids retain their resistance genes, such as tet(M), tet(B), floR, mph(A)-like, mef(A)-like, and sul2, which confer resistance to tetracycline, florfenicol, macrolides, and sulfonamides.
Apramycin treatment affects selection and spread of a multidrug-resistant Escherichia coli strain able to colonize the human gut in the intestinal microbiota of pigs.
The study identifies multiple AMR genes in the multidrug-resistant E. coli strain 912, including aac(3)-IV, blaTEM-1, sul2, aph(4), tet(X), and strA/B, which confer resistance to various antibiotics such as gentamicin, apramycin, sulfonamides, aminoglycosides, tetracyclines, and streptomycin.
Draft Genome Sequence of Proteus mirabilis NO-051/03, Representative of a Multidrug-Resistant Clone Spreading in Europe and Expressing the CMY-16 AmpC-Type β-Lactamase.
The draft genome sequence of Proteus mirabilis NO-051/03 reveals the presence of multiple acquired resistance genes, including blaCMY-16 and blaTEM-1b, which confer resistance to β-lactams, as well as genes for resistance to aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, and sulfonamides. Additionally, mutations in gyrA, gyrB, and parC contribute to fluoroquinolone resistance.
Comparative Genomic Analysis of Mannheimia haemolytica from Bovine Sources.
The study identified a bla ROB-1 gene in an integrative conjugative element (ICE) of M. haemolytica, which had a single nucleotide substitution leading to a non-functional gene and sensitivity to ampicillin.
Carriage of Extended-Spectrum Beta-Lactamase-Plasmids Does Not Reduce Fitness but Enhances Virulence in Some Strains of Pandemic E. coli Lineages.
The study found that ESBL-plasmid carriage does not reduce fitness but enhances virulence in some strains of pandemic E. coli lineages. It identified several AMR genes on the ESBL-plasmids, including beta-lactamases (blaCTX-M-15, blaCTX-M-27, blaCTX-M-14), tetracycline resistance genes (tetA, tetR), aminoglycoside resistance genes (aadA, aac(6')-Ib-cr), chloramphenicol resistance gene (catB4), sulfonamide resistance gene (sul2), streptomycin resistance genes (strA, strB), dihydrofolate reductase genes (dhfrVII, dfrA17), and aminoglycoside phosphotransferase gene (aph(3')-Ia). Non-antibiotic resistance genes such as finO, traT, icc, yfaX, yihA, and hha were also identified.
Comparative genomic analysis of six new-found integrative conjugative elements (ICEs) in Vibrio alginolyticus.
The study identified drug-resistant genes, including strBA and sul2, within certain integrative conjugative elements (ICEs) in Vibrio alginolyticus strains.
Interconnected microbiomes and resistomes in low-income human habitats.
The study identified several antibiotic resistance genes, including beta-lactamases, sulfonamide-resistant dihydropteroate synthetase (Sul2), and tetracycline-inactivating enzymes (TetX), which contribute to resistance against various antibiotics in human and environmental microbiota from low-income communities.
Antibiotic Resistance, Core-Genome and Protein Expression in IncHI1 Plasmids in Salmonella Typhimurium.
The study identified multiple antibiotic resistance genes in IncHI1 plasmids of Salmonella Typhimurium, including tet(B), tet(A), blaTEM, strA, strB, sul2, aadA, dfrA, catA1, aphA1a, and aad(3)IId, which confer resistance to various antibiotics such as tetracycline, beta-lactam, streptomycin, sulfonamide, aminoglycoside, chloramphenicol, and trimethoprim.
Prevalence of virulence and antimicrobial resistance genes in Salmonella spp. isolated from commercial chickens and human clinical isolates from South Africa and Brazil.
The study identified the presence of virulence and antimicrobial resistance genes in Salmonella isolates from commercial chickens and human clinical samples in South Africa and Brazil. Key resistance genes included pse-1 (ampicillin), ant (3")-la (gentamicin), tet A and tet B (tetracycline), and sul 1 and sul 2 (sulfamethoxazole).
SSTAR, a Stand-Alone Easy-To-Use Antimicrobial Resistance Gene Predictor.
The study presents SSTAR, a software tool for identifying antimicrobial resistance (AR) genes from whole-genome sequencing data. It detects known AR genes and potential new variants, including truncated forms. The tool was applied to analyze resistance genes in Klebsiella pneumoniae ST437 and Escherichia coli ST44, revealing various beta-lactamases, aminoglycoside resistance genes, and porin mutations contributing to resistance.
Increase in the Prevalence of Resistance Determinants to Trimethoprim/Sulfamethoxazole in Clinical Stenotrophomonas maltophilia Isolates in China.
The study identified several resistance genes, including qacEΔ1-sul1, sul2, intI1, dfrA12, dfrA17, and dfrA27, which are associated with trimethoprim/sulfamethoxazole resistance in Stenotrophomonas maltophilia isolates in China.
Whole-Genome Sequencing for Detecting Antimicrobial Resistance in Nontyphoidal Salmonella.
The study identified 65 unique resistance genes in nontyphoidal Salmonella, including bla CTX-M1 and bla SHV2a, which were first reported in retail meat isolates in the United States. The research highlights the effectiveness of whole-genome sequencing in detecting antimicrobial resistance genes and correlating them with phenotypic resistance.
Identification of an NDM-5-producing Escherichia coli Sequence Type 167 in a Neonatal Patient in China.
The study identifies NDM-5-producing Escherichia coli ST167 in a neonatal patient in China, highlighting the spread of carbapenem resistance through the bla NDM-5 gene and other resistance mechanisms.
Characterization of Two Multidrug-Resistant IncA/C Plasmids from the 1960s by Using the MinION Sequencer Device.
The study characterizes two multidrug-resistant IncA/C plasmids, R16a and IP40a, from the 1960s, identifying resistance genes blaTEM-1D, aphA1b, and sul2, which confer resistance to ampicillin, kanamycin, and sulfonamides, respectively.
Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.
The study identified multiple S. Typhi genotypes in Nigeria, with a focus on antimicrobial resistance genes and plasmids. Key resistance genes included blaTEM-1, catA1, tetB, dfrA15, sul1, sul2, strAB, aad, and qnrS, primarily associated with the IncHI1 plasmid. Quinolone resistance was linked to gyrA mutations S83Y and S83F.
Architecture of Class 1, 2, and 3 Integrons from Gram Negative Bacteria Recovered among Fruits and Vegetables.
The study identified several AMR genes in Gram-negative bacteria from fresh produce, including mcr-1, qnrA1, blaGES-11, mphA, and oqxAB, highlighting the presence of mobile genetic elements and clinically relevant resistance genes.
Antimicrobial Susceptibility of Autochthonous Aquatic Vibrio cholerae in Haiti.
The study identified several AMR genes in environmental isolates of Vibrio cholerae non-O1/non-O139 in Haiti, including strA, strB, sul1, sul2, ermA, ermB, and mefA, which confer resistance to streptomycin, sulfonamide, and erythromycin.
Draft Genomic Analysis of an Avian Multidrug Resistant Morganella morganii Isolate Carrying qnrD1.
The study reports the draft genome sequence of a multidrug-resistant Morganella morganii isolate carrying the qnrD1 gene, along with various other antibiotic resistance genes such as aadA1y, aph(3')-Ic, strA-strB, blaOXA-1, catA2, catB3, sul2, dfrA1, tetY, and sat2.
Comparative Genome Analysis of Extended-Spectrum-β-Lactamase-Producing Escherichia coli Sequence Type 131 Strains from Nepal and Japan.
The study identified multiple AMR genes, including blaCTX-M-15, blaOXA-1, aac(6')-Ib-cr, tet(A), mphA, strA, strB, aadA5, sul1, sul2, dfrA12, dfrA17, catA1, and catB3, in ESBL-producing E. coli ST131 isolates from Nepal and Japan. These genes conferred resistance to various antibiotics, including β-lactams, aminoglycosides, tetracyclines, macrolides, sulfonamides, and chloramphenicol.
Surveillance of Dihydropteroate Synthase Genes in Stenotrophomonas maltophilia by LAMP: Implications for Infection Control and Initial Therapy.
The study developed LAMP assays for the detection of sul1 and sul2 genes in Stenotrophomonas maltophilia, which are responsible for sulfamethoxazole resistance. The LAMP assays showed high sensitivity and specificity, and the study found that sul1 and sul2 were prevalent in sulfamethoxazole-resistant strains.
Genomic signatures of Mannheimia haemolytica that associate with the lungs of cattle with respiratory disease, an integrative conjugative element, and antibiotic resistance genes.
The study identifies multiple antibiotic resistance genes in Mannheimia haemolytica, particularly in genotype 2, subtype 2b isolates, which are associated with the lungs of cattle with respiratory disease and contain various combinations of resistance genes.
Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms.
The study identifies multiple carbapenemase genes (bla KPC-2, bla KPC-3, bla KPC-4, and bla NDM-1) and other resistance genes (such as qnrB19, qnrB2, qnrS1, bla TEM-1A, bla TEM-1B, bla OXA-9, bla SHV-12, aadA2, aac(6')-Ib, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ic, strA, strB, sul1, sul2, dfrA14, dfrA18, mph(A), catB3, arr-3, and tet(D)) in carbapenem-resistant Enterobacter spp. These genes are primarily located on plasmids and contribute to multidrug resistance.
Characterisation of Commensal Escherichia coli Isolated from Apparently Healthy Cattle and Their Attendants in Tanzania.
The study identified several antimicrobial resistance genes in commensal E. coli isolates from cattle and their attendants in Tanzania, including blaTEM-1B, sul1, sul2, and tet(A). These genes conferred resistance to beta-lactams, sulfamethoxazole-trimethoprim, and tetracycline, respectively.
Whole-Genome Analysis of Antimicrobial-Resistant and Extraintestinal Pathogenic Escherichia coli in River Water.
The study identified numerous antimicrobial resistance genes in Escherichia coli isolates from river water, highlighting the presence of multidrug-resistant and extraintestinal pathogenic strains. Key resistance genes included blaTEM-1, aac(3)-IId, qnrB7, and others.
Draft Genome Sequences of Pandrug-Resistant Serratia marcescens Clinical Isolates Harboring blaNDM-1.
The study reports the draft genome sequences of two pandrug-resistant Serratia marcescens clinical isolates carrying multiple antibiotic resistance genes, including blaNDM-1, blaSHV-12, blaTEM-1B, blaCMY-6, sul1, sul2, rmtC, aacA4, aac(6')Ib-c, strA, strB, dfrA18, qnrA1, catA2, aac(6')-Ic, tet(41), and ampC.
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
Marine Bivalve Mollusks As Possible Indicators of Multidrug-Resistant Escherichia coli and Other Species of the Enterobacteriaceae Family.
The study identified multiple AMR genes in E. coli isolates from marine bivalves, including bla TEM-1, bla CTX-M-14, bla CTX-M-15, and various aminoglycoside, trimethoprim, sulfonamide, tetracycline, chloramphenicol, quinolone, and macrolide resistance genes. These findings highlight the potential risk of MDR Enterobacteriaceae in marine environments.
Carbapenem-resistance and pathogenicity of bovine Acinetobacter indicus-like isolates.
The study identifies carbapenem-resistant Acinetobacter indicus-like isolates from cattle carrying the blaOXA-23 gene, along with various other AMR genes such as aac(3)-IIa, strA/B, aph(3')-Ic, sul2, floR, tet(A), tet(Y), aadA1, aadB, sul1, and tet(X).
Identification of a novel sequence type of Escherichia coli as the causative agent of pyelonephritis and bloodstream infection.
The study identifies a novel sequence type of Escherichia coli (ST-458) responsible for pyelonephritis and bloodstream infection, carrying multiple antibiotic resistance genes and mutations associated with resistance to fluoroquinolones, aminoglycosides, sulfonamides, and beta-lactams.
Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant Acinetobacter baumannii global clone 1.
The study identified multiple mutations in genes such as parC, gyrA, acrB, adeR, and ampC that contribute to fluoroquinolone and beta-lactam resistance in Acinetobacter baumannii global clone 1. Horizontal gene transfer events, particularly the acquisition of the AbaR resistance island, played a significant role in the development of multidrug resistance.
Whole-Genome Sequencing of Drug-Resistant Salmonella enterica Isolates from Dairy Cattle and Humans in New York and Washington States Reveals Source and Geographic Associations.
The study identified several AMR genes and mutations in Salmonella enterica isolates from dairy cattle and humans in New York and Washington States, highlighting the role of geographic and source-specific factors in AMR dissemination.
Genomic Analysis of Factors Associated with Low Prevalence of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli Sequence Type 95 Strains.
The study identifies several AMR genes in ST95 E. coli strains, including blaTEM-1, blaCTX-M14, aadA1, aadA2, aadA5, aac3, strA, strB, tetA, tetB, tetD, sul1, sul2, dfrA5, dfrA12, dfrA17, mphA, and catA1, which confer resistance to various antibiotics such as ampicillin, cephalothin, streptomycin, tetracycline, sulfamethoxazole, trimethoprim, azithromycin, and chloramphenicol.
Genome sequence of Shigella flexneri strain SP1, a diarrheal isolate that encodes an extended-spectrum β-lactamase (ESBL).
The study identifies the presence of multiple antibiotic resistance genes in the Shigella flexneri strain SP1, including blaCTX-M-14, blaOXA-1, aadA24, strA, strB, catA1, tetD, sul2, and dfrA1, which contribute to its multidrug-resistant phenotype.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
Genomic Analysis of Multidrug-Resistant Escherichia coli from North Carolina Community Hospitals: Ongoing Circulation of CTX-M-Producing ST131-H30Rx and ST131-H30R1 Strains.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from North Carolina community hospitals, including bla CTX-M-15, bla CTX-M-14, aac(6′)-Ib-cr, qnrS1, and mutations in gyrA, parC, and parE that confer resistance to various antibiotics.
Characterization of the Complete Nucleotide Sequences of IncA/C2 Plasmids Carrying In809-Like Integrons from Enterobacteriaceae Isolates of Wildlife Origin.
The study characterized IncA/C2 plasmids carrying In809-like integrons from Enterobacteriaceae isolates of wildlife origin, identifying several AMR genes including blaIMP-4, blaIMP-26, blaIMP-38, sul2, floR, aac(3)-IId, qnrA1, arr-3, dfrA12, aphA1, aadA16, aadA2, blaOXA-1, blaTEM-1, and blaDHA-1.
An In Vitro Chicken Gut Model Demonstrates Transfer of a Multidrug Resistance Plasmid from Salmonella to Commensal Escherichia coli.
The study demonstrates the transfer of a multidrug resistance plasmid, pIFM3844, from Salmonella to commensal E. coli, highlighting the role of the bla CTX-M1 gene in conferring resistance to cefotaxime.
Genomic characterization of novel IncFII-type multidrug resistant plasmids p0716-KPC and p12181-KPC from Klebsiella pneumoniae.
The study characterizes two novel IncFII-type multidrug-resistant plasmids, p0716-KPC and p12181-KPC, from Klebsiella pneumoniae. These plasmids carry multiple resistance genes, including blaKPC-2, mph(A), strAB, aacC2, qacEΔ1, sul1, sul2, dfrA25, aphA1a, and blaTEM-1, contributing to resistance against various antibiotics.
Comparative Sequence Analysis of Multidrug-Resistant IncA/C Plasmids from Salmonella enterica.
The study identified multiple antimicrobial resistance genes on IncA/C plasmids from various Salmonella serovars, including bla_cmy-2, bla_tem-1, strA, strB, aadB, aph(3')-Ia, tetA, floR, cmlA, sul1, sul2, dfra12, quacE, sugE, merA, merB, merC, merD, and merE, which contribute to multidrug resistance.
Resistance to Antibiotics, Biocides, Preservatives and Metals in Bacteria Isolated from Seafoods: Co-Selection of Strains Resistant or Tolerant to Different Classes of Compounds.
The study identified multiple antibiotic resistance genes, including sul1, sul2, floR, aadA1, aac(6')-Ib, blaTEM, blaCTX-M, blaPSE, blaNDM-1, qacEΔ1, pcoA/copA, chrB, and pcoR, in bacterial isolates from seafood. These genes conferred resistance to sulfonamides, phenicols, aminoglycosides, beta-lactams, and heavy metals.
The clinical and microbiological characteristics of enteric fever in Cambodia, 2008-2015.
The study identified various AMR genes and mutations in Salmonella Typhi and Salmonella Paratyphi A isolates from Cambodia, including beta-lactamase (blaTEM-1B), chloramphenicol acetyltransferase (catA1), sulfonamide resistance proteins (sul1, sul2), dihydrofolate reductase (dfrA7), tetracycline resistance protein (tet(B)), and streptomycin resistance protein (strAB). Additionally, mutations in the gyrA and gyrB genes were associated with decreased ciprofloxacin susceptibility.
Rapid Nanopore Sequencing of Plasmids and Resistance Gene Detection in Clinical Isolates.
The study demonstrates the feasibility of rapid nanopore sequencing for detecting plasmid-borne antimicrobial resistance (AMR) genes in clinical isolates. It identifies several AMR genes, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, tetracycline resistance genes, macrolide resistance genes, and phenicol resistance genes, in both Escherichia coli and Klebsiella pneumoniae isolates.
Genome sequencing of 39 Akkermansia muciniphila isolates reveals its population structure, genomic and functional diverisity, and global distribution in mammalian gut microbiotas.
The study identified the acquisition of antibiotic resistance genes, including sul2, aph(6)-Id, and aph(3"-Ib, through lateral gene transfer in Akkermansia muciniphila GP36, which conferred resistance to sulfonamides and aminoglycosides.
pirAB(vp)-Bearing Vibrio parahaemolyticus and Vibrio campbellii Pathogens Isolated from the Same AHPND-Affected Pond Possess Highly Similar Pathogenic Plasmids.
The study identifies antibiotic resistance genes in Vibrio parahaemolyticus and Vibrio campbellii strains isolated from an AHPND-affected pond, highlighting the presence of tetracycline, sulfonamide, streptomycin, and florfenicol resistance mechanisms.
Extensively Drug-Resistant Escherichia coli Sequence Type 1642 Carrying an IncX3 Plasmid Containing the blaKPC-2 Gene Associated with Transposon Tn4401a.
The study identifies several AMR genes in an extensively drug-resistant E. coli ST1642 isolate, including blaKPC-2, blaSHV-11, blaTEM-1, aadA5, strA, strB, aac(3)-IId, mph(A), sul1, sul2, tet(B), dfrA17, and qnrS1, which contribute to resistance against multiple antibiotics.
VIM-1 carbapenemase-producing Escherichia coli isolated from retail seafood, Germany 2016.
The study identifies a VIM-1 carbapenemase-producing E. coli isolate from retail seafood in Germany, highlighting the presence of multiple resistance genes including blaVIM-1, aacA4, aadA1, aph(3')-XV, catB2, qnrS1, blaSHV-12, blaACC-1, strA-like, strB-like, dfrA14-like, mph(A), sul1, and sul2.
Plant Growth, Antibiotic Uptake, and Prevalence of Antibiotic Resistance in an Endophytic System of Pakchoi under Antibiotic Exposure.
The study identified the presence of tetX, blaCTX-M, sul1, and sul2 genes in the endophytic system of pakchoi under antibiotic exposure, indicating the development of antibiotic resistance in response to tetracycline, cephalexin, and sulfamethoxazole.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting.
The study identified various AMR genes and mutations in E. coli isolates from children with cystic fibrosis, cancer, and healthy controls, highlighting differences in resistance profiles between groups.
ARIBA: Rapid identification of antimicrobial resistance genes and variants from whole-genome sequencing data
The paper presents ARIBA, a tool for identifying antimicrobial resistance genes and mutations from sequencing data. It evaluates the performance of ARIBA on three datasets, demonstrating its accuracy and efficiency in detecting resistance genes and mutations in Enterococcus faecium, Shigella sonnei, and Neisseria gonorrhoeae.
High Prevalence of CTX-M-15-Type ESBL-Producing E. coli from Migratory Avian Species in Pakistan.
The study identified a high prevalence of CTX-M-15-type ESBL-producing E. coli in migratory avian species in Pakistan, highlighting the role of wild birds as reservoirs of multidrug-resistant bacteria and the potential for horizontal gene transfer of resistance determinants.
Characterization of plasmids harboring blaCTX-M and blaCMY genes in E. coli from French broilers.
The study characterized blaCTX-M-1 and blaCMY-2 genes in E. coli isolates from French broilers, highlighting their roles in extended-spectrum cephalosporin resistance and the presence of virulence genes on blaCMY-2-containing plasmids.
Complete Genome Sequence of a bla(CTX-M-1)-Harboring Escherichia coli Isolate Recovered from Cattle in Germany.
The study reports the complete genome sequence of an Escherichia coli isolate carrying the bla(CTX-M-1) gene, along with other resistance genes including mph(A), sul2, dfrA5, strA, and strB, indicating multidrug resistance.
Comparison of antimicrobial resistance genes in feedlots and urban wastewater.
The study identified various antimicrobial resistance genes in feedlots and urban wastewater, highlighting the prevalence of sulfonamide, tetracycline, macrolide, fluoroquinolone, and β-lactam resistance genes in different environments.
Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population.
The study identifies clinically relevant ESBL-producing K. pneumoniae ST307 and E. coli ST38 in an urban West African rat population, highlighting the presence of multidrug-resistant strains carrying various resistance genes such as blaCTX-M-15, blaCTX-M-14, blaCTX-M-9, and others.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidal Salmonella enterica.
The study identified various AMR genes and mutations in non-typhoidal Salmonella enterica, including blaTEM-1, strA-strB, sul2, tet(A), qnrS1, aadA2, aadA17, floR, cmlA1, aac(3)-Id, aac(3)-IIa, dfrA12, dfrA1, dfrA14, blaCTX-M-9, blaCTX-M-55, blaSHV-12, blaPSE-1/blaCARB-2, and blaCMY-2, along with mutations in gyrA and parC associated with ciprofloxacin resistance.
Characterization of antimicrobial resistance genes in Haemophilus parasuis isolated from pigs in China.
The study identified multiple antimicrobial resistance genes in Haemophilus parasuis isolates from pigs in China, including blaTEM-1, blaROB-1, ermB, ermA, flor, catl, tetB, tetC, rmtB, rmtD, aadA1, aac(3′)-IIc, sul1, and sul2. Additionally, mutations in the gyrA and parC genes were associated with fluoroquinolone resistance.
An outbreak of a rare Shiga-toxin-producing Escherichia coli serotype (O117:H7) among men who have sex with men.
The study identified several AMR genes and mutations in STEC O117:H7 isolates, including the azithromycin resistance gene mphA, aadA1, aadA2, aadA5, blaTEM-1B, blaTEM-1C, dfrA1, dfrA12, dfrA14, dfrA, dfrA5, ermB, strA, strB, sul1, sul2, tet(A), tet(B), qnrs1, and a mutation in gyrA (S83L) associated with fluoroquinolone resistance.
Distribution and Genetic Characteristics of SXT/R391 Integrative Conjugative Elements in Shewanella spp. From China.
The study identified the SXT/R391 integrative conjugative element ICE Sup CHN110003 in Shewanella upenei strains, which carries antibiotic resistance genes floR, strA, strB, and sul2, conferring resistance to chloramphenicol, streptomycin, and sulfamethoxazole.
Isolation, Functional Characterization and Transmissibility of p3PS10, a Multidrug Resistance Plasmid of the Fish Pathogen Piscirickettsia salmonis.
The study identifies and characterizes the multidrug resistance plasmid p3PS10 in Piscirickettsia salmonis, which carries genes conferring resistance to chloramphenicol (cat2), tetracyclines (tetA(t31)), aminoglycosides (aadA1, sat1), and sulfonamides (sul2).
The Use of a Combined Bioinformatics Approach to Locate Antibiotic Resistance Genes on Plasmids From Whole Genome Sequences of Salmonella enterica Serovars From Humans in Ghana.
The study identified several AMR genes in Salmonella isolates from Ghana, including blaTEM-1B, blaTEM-52B, blaCTX-M-15, tet(A), dfrA15, sul1, sul2, catA1, strA, strB, aadA1, catB3, qnrB1, aac(6')Ib-cr, and blaOXA-1. These genes were found on various plasmids, highlighting the diversity of resistance mechanisms in the studied isolates.
Interplay of a non-conjugative integrative element and a conjugative plasmid in the spread of antibiotic resistance via suicidal plasmid transfer from an aquaculture Vibrio isolate.
The study identifies the plasmid pSEA1 and the integrative element Tn 6283, which carry various antibiotic resistance genes including tet(M), mef(C), mph(G), sul2, catII, and bla, facilitating the spread of antibiotic resistance in aquatic environments.
Seasonal Variations in Water-Quality, Antibiotic Residues, Resistant Bacteria and Antibiotic Resistance Genes of Escherichia coli Isolates from Water and Sediments of the Kshipra River in Central India.
The study identified the presence of antibiotic resistance genes such as bla CTX-M-1, qnr S, sul1, and sul2 in Escherichia coli isolates from the Kshipra River, showing seasonal variations in their occurrence and resistance profiles.
Genetic analysis of invasive Escherichia coli in Scotland reveals determinants of healthcare-associated versus community-acquired infections.
The study identified several antibiotic resistance genes in E. coli isolates, including blaCTX-M-15, blaCTX-M-9, aac(3)-II, aac(6')-Ib, aadA1, dfrA1, sul1, sul2, mphA, and mrxA, which contribute to resistance against various antibiotics such as third-generation cephalosporins, aminoglycosides, trimethoprim, sulfonamides, and macrolides.
A pan-genome-based machine learning approach for predicting antimicrobial resistance activities of the Escherichia coli strains.
The study identifies and characterizes several AMR genes in E. coli, including beta-lactamases (blaTEM-1, blaOXA-1, blaCMY-2, ampC), aminoglycoside modifying enzymes (aac(3')-Ia, aac(3')-VI), dihydrofolate reductases (dfrA1, dfrA5, dfrA12, dfrA15), quinolone resistance proteins (qnrB2, qnrB6, qnrS2), and others. These genes were validated through computational and wet lab methods, showing their roles in conferring resistance to various antibiotics.
Evolution and Comparative Genomics of F33:A-:B- Plasmids Carrying bla(CTX-M-55) or bla(CTX-M-65) in Escherichia coli and Klebsiella pneumoniae Isolated from Animals, Food Products, and Humans in China.
The study characterizes F33:A−:B− plasmids carrying various AMR genes such as bla(CTX-M-55), bla(CTX-M-65), fosA3, rmtB, and others in E. coli and K. pneumoniae isolates from diverse sources in China.
Alterations of Salmonella enterica Serovar Typhimurium Antibiotic Resistance under Environmental Pressure.
The study identifies tetracycline resistance gene tetA and sulfonamide resistance gene sul2 in Salmonella enterica serovar Typhimurium, demonstrating their role in antibiotic resistance under environmental pressure.
Superficieibacter electus gen. nov., sp. nov., an Extended-Spectrum β-Lactamase Possessing Member of the Enterobacteriaceae Family, Isolated From Intensive Care Unit Surfaces.
The study identifies multiple antibiotic resistance genes in the newly described species Superficieibacter electus, including beta-lactamases, aminoglycoside modifying enzymes, and others, indicating its ability to resist various antibiotics.
Variant O89 O-Antigen of E. coli Is Associated With Group 1 Capsule Loci and Multidrug Resistance.
The study identified a novel O89 O-antigen locus in E. coli strain 26561, which is associated with group 1 capsule (G1C) and multidrug resistance. The strain exhibits a mucoid and viscous phenotype, and possesses multiple AMR genes including blaCTX-M-14, blaTEM-1, aph(3")-Ib, strA, aph(6)-Id, strB, aph(3′)-Ia, sul2, tetA(B), and catA1. Mutations in gyrA (S83L, D87N) and parC (S80I) contribute to quinolone resistance.
Characterization of Salmonella enterica serovars recovered from meat products legally and illegally imported into the EU reveals the presence of multiresistant and AmpC-producing isolates.
The study identifies multiresistant Salmonella enterica isolates from legally and illegally imported meat, including AmpC-producing isolates carrying blaCMY-2, tet(A), and sul2 genes, which confer resistance to cephalosporins, tetracycline, and sulfonamides.
Genetic structure of four plasmids found in Acinetobacter baumannii isolate D36 belonging to lineage 2 of global clone 1.
The study identifies four plasmids in Acinetobacter baumannii isolate D36, including pRAY* carrying aadB, pD36-4 carrying aphA1a, sul2, and a mercury resistance module, and others with no resistance genes.
A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil.
The study reports a fatal case of bacteremia caused by a hypermucoviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae. The isolate harbored multiple AMR genes including blaKPC-2, blaSHV-11, qnrS1, oqxA, oqxB, sul1, sul2, dfrA1, tetA, tetD, and fosA, contributing to its extensive drug resistance.
Interplay Between the Phenotype and Genotype, and Efflux Pumps in Drug-Resistant Strains of Riemerella anatipestifer.
The study identified multiple AMR genes and mutations in Riemerella anatipestifer, including aac(6')-Ib, aadA1, aadA2, aadA5, aac(3')-IIc, aac(3')-IV, aph(3')-VII, aph(2')-Ib, bla TEM, bla OXA, tet(A), tet(B), sul1, sul2, sul3, cat2, cmlA, floR, emrF, qnrS, and qnrD. Additionally, mutations in gyrA and parC were found to confer fluoroquinolone resistance.
Draft genome sequence data of a tigecycline-resistant Enterobacter cloacae ST93 clinical strain isolated from bloodstream infection.
The study reports the draft genome sequence of a tigecycline-resistant Enterobacter cloacae ST93 clinical isolate, TREC1, which harbors multiple antimicrobial resistance genes, including those encoding resistance to beta-lactams, aminoglycosides, fluoroquinolones, fosfomycin, macrolides, lincosamides, streptogramin B, phenicols, sulfonamides, trimethoprim, and tetracyclines. The isolate is resistant to all antibiotics tested except colistin.
Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.
The study identified various AMR genes and mutations in carbapenem-resistant Klebsiella pneumoniae isolates, including bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-48, ampC, qnrB, qnrS, aac(6')-Ib-cr, armA, rmtB, tet(A), tet(B), tet(D), tet(G), sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, dfrA25, dfrA26, dfrA30, oqxA, oqxB, and mgrB, as well as mutations in ompK35, ompK36, gyrA, parC, phoP, phoQ, pmrA, and pmrB, which contribute to resistance against multiple antibiotics.
The Transferable Resistome of Produce.
The study identified multiple tetracycline resistance genes, beta-lactamases, and other resistance determinants in E. coli isolates from produce, highlighting the potential for horizontal gene transfer and the significance of the produce microbiome as a reservoir of antibiotic resistance genes.
Evidence of Illegitimate Recombination Between Two Pasteurellaceae Plasmids Resulting in a Novel Multi-Resistance Replicon, pM3362MDR, in Actinobacillus pleuropneumoniae.
The study identifies a novel multi-resistance plasmid, pM3362MDR, in Actinobacillus pleuropneumoniae, which carries the tetracycline resistance gene tet(B), as well as blaROB-1, sul2, and strA. The plasmid arose through illegitimate recombination between pTetHS016 and pOV.
Salmonella enterica Serovar Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial Resistance.
The study identified several AMR genes and mutations in S. Typhi isolates from Bangladesh, including blaTEM-1B, blaCTX-M-15, catA1, dfrA7, sul1, sul2, qnrS1, strA, strB, tet(A), tet(B), and mutations in gyrA and parE associated with ciprofloxacin resistance.
Emerging Multidrug-Resistant Hybrid Pathotype Shiga Toxin-Producing Escherichia coli O80 and Related Strains of Clonal Complex 165, Europe.
The study identifies multidrug-resistant hybrid pathotype Shiga toxin-producing E. coli O80 strains belonging to clonal complex 165, which harbor a mosaic plasmid with genes conferring resistance to multiple antibiotics, including beta-lactams, tetracyclines, sulfonamides, trimethoprim, kanamycin, streptomycin, and colistin.
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.
The study characterized the resistomes of six carbapenem-resistant pathogens, identifying various carbapenemase genes such as bla KPC-2, bla OXA-48, bla OXA-72, bla NDM-1, bla NDM-7, and bla VIM-1, along with other resistance genes like aac(6')-Ib-cr, aph(3")-Ib, aph(6)-Id, tet(B), erm(B), mph(A), sul1, sul2, dfrA17, dfrA14, bla CTX-M-15, bla CMY-6, bla OXA-1, bla SHV-200, bla OXA-10, and bla NDM-7.
High abundances of class 1 integrase and sulfonamide resistance genes, and characterisation of class 1 integron gene cassettes in four urban wetlands in Nigeria.
The study identified high abundances of class 1 integrase (intI1) and sulfonamide resistance genes (sul1 and sul2) in urban wetlands in Nigeria, along with various gene cassettes in class 1 integrons that confer resistance to trimethoprim, aminoglycosides, rifampicin, and fluoroquinolones.
The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.
The study identifies multiple AMR genes associated with multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa, including genes encoding resistance to aminoglycosides, beta-lactams, chloramphenicol, trimethoprim, sulfonamides, and tetracyclines. It also notes mutations in the gyrA gene associated with reduced susceptibility to fluoroquinolones.
Population Structure, Antibiotic Resistance, and Uropathogenicity of Klebsiella variicola.
The study identifies several antibiotic resistance genes in Klebsiella variicola, including blaLEN, oqxAB, blaKPC-2, blaNDM-1, blaNDM-9, blaOXA-48, aac(6')-Ib, aadA16, sul1, sul2, qnrB6, arr-3, and floR. These genes confer resistance to various antibiotics such as ampicillin, ciprofloxacin, meropenem, gentamicin, kanamycin, sulfamethoxazole, rifampin, and chloramphenicol.
Hospitalized Pets as a Source of Carbapenem-Resistance.
The study identified carbapenem-resistant bacteria in hospitalized pets, including Acinetobacter radioresistens carrying blaNDM-1 and Acinetobacter baumannii carrying blaOXA-23. Mutations in the oprD gene were associated with carbapenem resistance in Pseudomonas aeruginosa, and S. maltophilia exhibited resistance to trimethoprim/sulfamethoxazole due to sul1 and sul2 genes.
The Prevalence of Colistin Resistant Strains and Antibiotic Resistance Gene Profiles in Funan River, China.
The study identified mcr-1 and mcr-3 genes as the primary colistin resistance genes in the Funan River, along with other resistance genes such as sul1, sul2, aac(6')-Ib-cr, bla CTX-M, tetM, ermB, qnrS, and aph(3')-IIIa. These genes were found in various bacterial species, highlighting the presence of multidrug-resistant strains in the river.
Diarrheal bacterial pathogens and multi-resistant enterobacteria in the Choqueyapu River in La Paz, Bolivia.
The study identified multidrug-resistant Enterobacteriaceae in the Choqueyapu River, including E. coli and Enterobacter cloacae carrying bla CTX-M, bla KPC, bla NDM, bla VIM, and bla OXA-48 genes, highlighting the environmental spread of antibiotic resistance.
Multidrug Resistant Uropathogenic Escherichia coli ST405 With a Novel, Composite IS26 Transposon in a Unique Chromosomal Location.
The study identifies a novel composite IS26 transposon, Tn6242, in multidrug-resistant E. coli ST405, carrying resistance genes including dfrA17, aadA5, sul1, mphA, strA, strB, blaTEM-1b, and sul2.
Extensive drug resistant Salmonella enterica serovar Senftenberg carrying blaNDM encoding plasmid p5558 (IncA/C) from India.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Salmonella enterica serovar Senftenberg isolate, including blaNDM-1, blaTEM-1, blaOXA-9, blaCMY-2, aac(6')-Ia, aac(6')-Ib, aph(3')-Ib, aph(6')-Ib, ant(3'')-Ia, sul-1, sul-2, and florR. Additionally, mutations in gyrA (S83Y, D87G) and parC (S80I) were associated with fluoroquinolone resistance.
Whole-Genome Sequences of Five Acinetobacter baumannii Strains From a Child With Leukemia M2.
Five multidrug-resistant Acinetobacter baumannii strains from a child with leukemia M2 were characterized. They harbored blaOXA-51 and blaOXA-23 genes, which confer resistance to carbapenems.
Cross-Border Transmission of Salmonella Choleraesuis var. Kunzendorf in European Pigs and Wild Boar: Infection, Genetics, and Evolution.
The study identified multiple antimicrobial resistance genes in Salmonella Choleraesuis isolates, including aadA1, catA1, cmlA1, floR, mph(B), strA, strB, sul1, sul2, sul3, tet(A), tet(B), dfrA1, aph(3')-Ia, lnu(B), and blaTEM-1. These genes conferred resistance to various antibiotics such as streptomycin, chloramphenicol, florfenicol, erythromycin, sulfamethoxazole, tetracycline, trimethoprim, gentamicin, lincomycin, and ampicillin.
Genomic epidemiology of severe community-onset Acinetobacter baumannii infection.
The study identified AMR genes sul2, tet(B), and tet39 in Acinetobacter baumannii strains, along with mutations in gyrA and parC associated with ciprofloxacin resistance.
Loss and Gain in the Evolution of the Salmonella enterica Serovar Gallinarum Biovar Pullorum Genome.
The study identifies multiple multidrug resistance plasmids in Salmonella Pullorum, including pSPUR1, pSPUR2, pSPUR3, pSPUR4, and pSPUR5, which confer resistance to various antibiotics such as trimethoprim, streptomycin, sulfonamide, and tetracycline.
Whole Genome Sequencing of Extended Spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae Isolated from Hospitalized Patients in KwaZulu-Natal, South Africa.
The study characterized multiple AMR genes in ESBL-producing K. pneumoniae isolates, including bla TEM-1B, bla CTX-M-15, bla SHV-1, bla OXA-1, aad AI6, aac (6′)Ib-cr, aph (6)Id, aph (3′)-Ib, oqx A, oqx B, fos A, ARR-3, sul 1, sul 2, dfr A14, dfr A27, cat A1, and cat B4.
Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging Klebsiella pneumoniae ST101 Lineage.
The study characterizes the antimicrobial resistance genes and mutations in the emerging Klebsiella pneumoniae ST101 lineage, highlighting the presence of multiple resistance mechanisms including carbapenemases, extended-spectrum beta-lactamases, and various other resistance genes.
Occurrence of Transferable Integrons and sul and dfr Genes Among Sulfonamide-and/or Trimethoprim-Resistant Bacteria Isolated From Chilean Salmonid Farms.
The study identified the presence of sul1, sul2, dfrA12, and dfrA14 genes in sulfonamide- and/or trimethoprim-resistant bacteria from Chilean salmonid farms, highlighting their potential for horizontal gene transfer through plasmids and integrons.
Plasmids of Shigella flexneri serotype 1c strain Y394 provide advantages to bacteria in the host.
The study identifies the multidrug resistance plasmid pNV-Y394 in Shigella flexneri serotype 1c strain Y394, which carries the genes sul2, strA-strB, and tetA, conferring resistance to sulfonamide, streptomycin, and tetracycline, respectively.
Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors.
The study identified several antimicrobial resistance genes in Escherichia coli isolates from broiler chickens in Jordan, including tetA, tetB, int1, sul1, sul2, blaTEM, and cat. These genes were associated with resistance to various antibiotics such as tetracycline, sulfonamides, beta-lactams, and chloramphenicol.
Diverse Commensal Escherichia coli Clones and Plasmids Disseminate Antimicrobial Resistance Genes in Domestic Animals and Children in a Semirural Community in Ecuador.
The study identified various antimicrobial resistance (AMR) genes in commensal Escherichia coli isolates from children and domestic animals in a semirural community in Ecuador. These genes included blaTEM-1B, dfrA8, qnrB19, strA, strB, tetA, tetB, sul1, sul2, and others, contributing to resistance against multiple antibiotics such as ampicillin, trimethoprim, tetracycline, and sulfamethoxazole. The research highlights the role of plasmids in disseminating these AMR genes and emphasizes the complexity of AMR transmission in such environments.
Ceftriaxone-resistant Salmonella enterica serotype Typhi in a pregnant traveller returning from Karachi, Pakistan to Denmark, 2019.
The study reports a ceftriaxone-resistant Salmonella Typhi isolate carrying multiple resistance genes, including blaCTX-M-15, blaTEM-1B, qnrS1, sul1, sul2, dfrA7, aph[3]-1b, aph[6]-1d, aac[6]-1aa, and catA1. Additionally, a fluoroquinolone resistance mutation (gyrA S83F) was identified.
Evaluation of The Pathogenic Potential of Insecticidal Serratia marcescens Strains to Humans.
All S. marcescens strains were resistant to sulfamethoxazole due to the presence of sul1 or sul2 genes. The study highlights the potential pathogenicity of S. marcescens to humans and the risks associated with using antibiotic-resistant strains as bioinsecticides.
Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.
The study identified various AMR genes and mutations in Salmonella enterica serovar Typhimurium, including aadA, strAB, blaTEM, blaCARB, floR, cmlA1, catA1, qnrB19, sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, tetA, tetB, tetC, tetG, and mutations in gyrA. These genes and mutations were validated through whole genome sequencing and phenotypic ASTs.
Dissemination of Multidrug-Resistant Commensal Escherichia coli in Feedlot Lambs in Southeastern Brazil.
The study identified multiple multidrug-resistant commensal E. coli isolates in feedlot lambs in Brazil, carrying various AMR genes including bla CTX-M-2, bla CTX-M-8, bla CTX-M-14, bla CTX-M-15, bla CMY-2, aac(3)-IIa, ant(2")-Ia, qnrB, tetA, tetB, sul1, sul2, floR, and cmlA. These genes confer resistance to beta-lactams, aminoglycosides, quinolones, tetracyclines, sulfonamides, and phenicols.
Genomic Features of High-Priority Salmonella enterica Serovars Circulating in the Food Production Chain, Brazil, 2000-2016.
The study identified several AMR genes in Salmonella enterica isolates from Brazil, including qnrE1, qnrB19, qnrS1, blaCTX-M-2, blaCTX-M-8, blaCMY-2, aadA1, aadA2, aac(3)-IVa, aac(3)-IIa, aac(6')-Ib, floR, sul1, sul2, tet(A), tet(B), strA, strB, drfA1, inu(F), qacEdelta1, and fosA7. These genes conferred resistance to various antibiotics such as fluoroquinolones, beta-lactams, aminoglycosides, sulfonamides, tetracyclines, chloramphenicol, trimethoprim, macrolides, quaternary ammonium compounds, and fosfomycin.
Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal.
Emergence of Multidrug-Resistant Salmonella enterica Serovar Goldcoast Strains in Taiwan and International Spread of the ST358 Clone.
The study identifies multiple multidrug-resistant Salmonella enterica serovar Goldcoast strains in Taiwan, highlighting the emergence of an ST358 clone carrying various resistance genes, including blaCTX-M-55, mcr-1, and others, contributing to the rapid increase in infections.
Population dynamics of an Escherichia coli ST131 lineage during recurrent urinary tract infection.
The study identified multiple AMR genes and mutations in E. coli ST131 isolates from a patient with recurrent UTIs, including plasmid-borne resistance genes and chromosomal mutations contributing to fluoroquinolone resistance.
Multilocus sequence typing and bla (ESBL) characterization of extended-spectrum beta-lactamase-producing Escherichia coli isolated from healthy humans and swine in Northern Thailand.
The study identified bla CTX-M, bla TEM, and bla SHV as the primary ESBL genes in ESBL-producing E. coli isolates from healthy humans and swine in Northern Thailand. Additionally, several other AMR genes such as sul1, sul2, sul3, aadA22, aph(3')-Ia, strA, strB, aadA2, aadA5, qnrS1, tetA, tetB, tetD, arr2, and mefB were characterized.
Whole-genome sequence analysis of multidrug-resistant uropathogenic strains of Escherichia coli from Mexico.
The study identified 29 antibiotic resistance genes in 24 multidrug-resistant uropathogenic E. coli strains from Mexico, including genes conferring resistance to aminoglycosides, fluoroquinolones, beta-lactams, chloramphenicol, sulfonamides, tetracycline, and trimethoprim. Notably, the genes strA, strB, blaTEM-1B, and sul2 were highly prevalent among the strains.
Characterization of Discriminatory Antimicrobial Resistance Genes in Aquatic Environments Using Machine Learning
The study identifies discriminatory antibiotic resistance genes (ARGs) using an extremely randomized tree (ERT) algorithm, highlighting genes like sul1, tet(W), and ermB as significant markers for differentiating resistomes across various aquatic environments.
Serotype, antimicrobial susceptibility and genotype profiles of Salmonella isolated from duck farms and a slaughterhouse in Shandong province, China.
The study identified multiple antimicrobial resistance genes, including blaTEM, sul2, aadA7, aac3-Id, aadA5, and dfrA17, in Salmonella isolates from duck farms and a slaughterhouse in Shandong, China. High levels of resistance to various antibiotics were observed, highlighting the need for improved antimicrobial stewardship.
Evolution of Outbreak-Causing Carbapenem-Resistant Klebsiella pneumoniae ST258 at a Tertiary Care Hospital over 8 Years.
The study identifies various AMR genes in ST258 K. pneumoniae isolates, including blaKPC-2, blaKPC-3, aadA2, aadA1, blaTEM-1A, blaSHV-11, blaSHV-12, oqxA, oqxB, fosA, dfrA12, dfrA14, sul1, sul2, catA1, cml, and strAB, which confer resistance to multiple antibiotics.
Genetic characterization of a novel sequence type of multidrug-resistant Citrobacter freundii strain recovered from wastewater treatment plant.
The study reports the identification of a multidrug-resistant Citrobacter freundii strain R17 carrying 13 antibiotic-resistance genes, including blaCMY-85, aadA2, aac(3)-lld, blaDHA-1, blaTEM-1B, qnrB4, mph(A), catA2, sul1, sul2, tet(D), and dfrA12, which confer resistance to various antibiotic classes.
Antibiotic resistance of Escherichia coli isolated from captive Bengal tigers at Safari parks in Bangladesh.
The study identified blaTEM and sul2 genes in E. coli isolates from Bengal tigers, indicating resistance to ampicillin and sulfamethoxazole-trimethoprim, respectively.
Horizontal gene transfer contributes to virulence and antibiotic resistance of Vibrio harveyi 345 based on complete genome sequence analysis.
The study identified 25 antibiotic resistance genes in Vibrio harveyi 345, including genes for tetracycline (tetm, tetb), fluoroquinolone (qnrs), trimethoprim (dfra17), sulfonamide (sul2), and others, highlighting the role of horizontal gene transfer in its multidrug resistance.
Comparative genome analysis of 15 clinical Shigella flexneri strains regarding virulence and antibiotic resistance.
The study identified the sulfonamide resistance gene sul2 in Shigella flexneri strains, highlighting its association with antibiotic resistance.
Manure Application Did Not Enrich Antibiotic Resistance Genes in Root Endophytic Bacterial Microbiota of Cherry Radish Plants.
The study found that manure application increased the occurrence of antibiotic resistance genes (ARGs) in the rhizosphere and phyllosphere of cherry radish, but not in the endophytic bacterial microbiota of the root, which is the edible part of the plant.
The Resistome, Mobilome, Virulome and Phylogenomics of Multidrug-Resistant Escherichia coli Clinical Isolates from Pretoria, South Africa.
The study characterized the resistome, mobilome, and virulome of 20 multidrug-resistant E. coli isolates from Pretoria, South Africa. Key findings include the identification of various beta-lactamase genes (blaCTX-M-15, blaCTX-M-14, blaCTX-M-27, blaOXA-1, blaOXA-10, blaTEM-1B), aminoglycoside resistance genes (aac(3)-IIa, aac(3)-IId, aac(6')-Ib-cr, mph(A)), sulfonamide resistance genes (sul1, sul2, sul3), dihydrofolate reductase genes (dfrA17, dfrA14, dfrA1, dfrA5, dfrA7, dfrA12, dfrA23), tetracycline resistance genes (tet(A), tet(B)), chloramphenicol resistance genes (catB3, catA1), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE.
Resistome metagenomics from plate to farm: The resistome and microbial composition during food waste feeding and composting on a Vermont poultry farm.
The study identified 50 unique antibiotic resistance genes (ARGs) in food waste, compost, and farm products, with a focus on aminoglycoside, tetracycline, and macrolide resistance. Key ARGs included aph(6)-1d, lmrD, mefA, mel, abeM, abeS, adeF, adeG, adeI, adeJ, adeK, emrD, sul2, tetH, tetM, tetO, tetW, and tetX, which were found in various samples and showed resistance to multiple drug classes.
Type 1, 2, and 1/2-Hybrid IncC Plasmids From China.
The study identifies several beta-lactamase genes (bla CMY-6, bla CTX-M-3, bla CTX-M-14, bla IMP-8, bla NDM-1) and a sulfonamide resistance gene (sul2) in various IncC plasmids from China. These genes confer resistance to multiple antibiotics, including cephalosporins, carbapenems, and sulfonamides.
Molecular Detection Of Multidrug-Resistant Salmonella Isolated From Livestock Production Systems In South Africa.
The study identified multiple multidrug-resistant Salmonella isolates from livestock in South Africa, highlighting the presence of resistance genes such as blaTEM-1, blaCMY-2, tetA, tetC, sul2, and dfrA7.
Characterization of a Novel Conjugative Plasmid in Edwardsiella piscicida Strain MS-18-199.
The study characterizes a novel conjugative plasmid, pEPMS-18199, in Edwardsiella piscicida strain MS-18-199, which carries multiple antimicrobial resistance (AMR) genes including floR, tetA, tetR, sul2, strA, strB, arsA, and arsD, conferring resistance to phenicol, tetracycline, sulfonamide, and aminoglycoside antibiotics, as well as arsenic.
Phylogenetic Diversity, Antimicrobial Susceptibility and Virulence Characteristics of Escherichia coli Isolates from Pigeon Meat.
The study identified several AMR genes in E. coli isolates from pigeon meat, including ampC, aadA, cmlA, sul1, sul2, and sul3, which confer resistance to beta-lactams, aminoglycosides, chloramphenicol, and sulfonamides.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Multidrug-Resistant and Clinically Relevant Gram-Negative Bacteria Are Present in German Surface Waters.
The study identifies several AMR genes in multidrug-resistant Gram-negative bacteria isolated from German surface waters, highlighting the presence of clinically relevant resistance mechanisms such as bla CTX-M-1, bla CTX-M-15, mcr-1, and others.
Emergence of carbapenemase-producing Enterobacteriaceae in Malawi.
The study reports the detection of an NDM-5 producing E. coli in Malawi, highlighting the emergence of carbapenem-resistant Enterobacteriaceae in the region.
Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing.
The study identified multiple AMR genes in extensively drug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (blaSHV-11, blaTEM-1B, blaVEB-1, blaOXA-10, blaKPC-2, blaOXA-9, blaVIM-27, blaCTX-M-15, blaOXA-1, blaOXA-48), aminoglycoside resistance genes (aadA1, ant(2'')-Ia, aph(6)-Id, arr-2, aadA24, aph(3')-Ia, aph(6)-Id, aac(3)-IIa, aac(6')Ib-cr, aac(6')-Ib, aac(6')-Ib-cr), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet(A), tet(G)), trimethoprim resistance genes (dfrA1, dfrA14, dfrA23), chloramphenicol resistance genes (cmlA1, catB4), and others.
Molecular characterization of avian pathogenic Escherichia coli from broiler chickens with colibacillosis.
The study identified several AMR genes in APEC isolates, including beta-lactamases (bla TEM-1, bla CTX-M-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(3)-II), plasmid-mediated quinolone resistance genes (qnrA, qnrS), tetracycline resistance genes (tetA), sulfonamide resistance genes (sul2), and chloramphenicol resistance genes (catA1, cmlA).
Whole Genome Sequencing of Escherichia coli From Store-Bought Produce.
The study identified various antimicrobial resistance genes in tetracycline-resistant E. coli strains from store-bought produce, highlighting the prevalence of multidrug resistance and the role of plasmids and integrons in the spread of resistance.
Population structure and antimicrobial resistance patterns of Salmonella Typhi isolates in urban Dhaka, Bangladesh from 2004 to 2016.
Emerging colistin resistance in Salmonella enterica serovar Newport isolates from human infections
Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: prevalence, risk factors, and molecular epidemiology.
The study identified several AMR genes in Gram-negative bacteria isolated from LTCF residents, including bla CTX-M-27, bla CTX-M-14, bla TEM-1B, bla IMP-1, and others, which confer resistance to various antibiotics such as β-lactams, aminoglycosides, and fluoroquinolones.
Genotypic characterization of multiple drug resistant Escherichia coli isolates from a pediatric cancer hospital in Egypt.
The study identified multiple drug-resistant Escherichia coli isolates from a pediatric cancer hospital in Egypt, highlighting the prevalence of various antimicrobial resistance genes such as TEM-220, NDM-11, aph(6)-Id, sul2, and others, indicating a significant threat to immunocompromised patients.
Genome-Based Analysis of Extended-Spectrum β-Lactamase-Producing Escherichia coli in the Aquatic Environment and Nile Perch (Lates niloticus) of Lake Victoria, Tanzania.
The study identified multiple AMR genes in ESBL-producing E. coli from Nile perch and water samples in Lake Victoria, including bla CTX-M-15, bla TEM-1B, aadA2, aac(3)-IId, sul1, sul2, dfrA12, qepA4, tetB, tetD, mphA, mdfA, catA1, strA, strB, nfaE, iss, vat, and lpfA.
Genotypic and phylogenetic characterisation of a clinical Ralstonia pickettii strain carrying two novel OXA allelic variants, bla(OXA-898) and bla(OXA-899), isolated from a bloodstream infection in China.
The study reports the first genome sequence of a clinical Ralstonia pickettii strain carrying two novel class D beta-lactamase genes, bla(OXA-898) and bla(OXA-899), isolated from a bloodstream infection in China. The strain was resistant to aminoglycosides and carbapenems, including meropenem.
Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium.
The study identified 24 different antimicrobial-resistance determinants in Gallibacterium anatis isolates from calves with unresponsive bronchopneumonia, including novel resistance genes such as aadA23, blaCARB-8, tet(Y), and qnrD1.
Phylogenetic Grouping of Human Ocular Escherichia coli Based on Whole-Genome Sequence Analysis.
The study identified 22 AMR genes in 10 ocular E. coli isolates, including bla CTX-M-15, dfrA17, aadA2, aadA5, bla OXA-1, bla NDM-5, dfrA12, bla TEM-1 B, mdfA, emrB, mphA, sul1, sul2, and aac(6')-1b-cr. Additionally, chromosomal mutations in parE, gyrA, and parC were found to confer resistance to fluoroquinolones.
Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report.
Putative Protein Biomarkers of Escherichia coli Antibiotic Multiresistance Identified by MALDI Mass Spectrometry.
The study identifies several AMR genes in E. coli isolates, including tet(A), tet(B), blaCTX-M, blaTEM, blaSHV, sul1, sul2, sul3, cmlA, aac(3)-II, aac(3)-IV, aadA, and strA-strB, which confer resistance to tetracycline, ampicillin, cefoxitin, trimethoprim-sulfamethoxazole, chloramphenicol, gentamicin, and streptomycin.
Characterization of an IMP-4-Producing Klebsiella pneumoniae ST1873 Strain Recovered from an Infant with a Bloodstream Infection in China.
The study characterizes an IMP-4-producing Klebsiella pneumoniae ST1873 strain, identifying multiple antimicrobial resistance genes including blaIMP-4, blaSHV-2, blaSHV-11, oqxA, oqxB, aph(6)-Id, strA, catA1, dfrA5, sul2, and fosA.
Metadata Analysis of mcr-1-Bearing Plasmids Inspired by the Sequencing Evidence for Horizontal Transfer of Antibiotic Resistance Genes Between Polluted River and Wild Birds.
The study identifies the mcr-1 gene as a key factor in colistin resistance in E. coli strains isolated from polluted rivers and wild birds. It also characterizes several other AMR genes including aadA1, aadA2, aph(3′)-Ia, aph(3″)-Ib, aph(4)-Ia, aph(6)-Id, tet(B), tet(D), tet(A), bla CTX–M–14, bla TEM–1, qnrS2, oqxA, oqxB, cmlA1, floR, vgaC, sul1, sul2, sul3, dfrA12, and glpT (E448K).
Antibiotic-resistant Escherichia coli isolated from urban rodents in Hanoi, Vietnam.
The study identified multiple antimicrobial resistance genes in Escherichia coli isolated from urban rodents in Hanoi, Vietnam, including bla TEM, tet(A), sul1, sul2, sul3, and mcr-1, highlighting the potential of rodents as reservoirs of multidrug-resistant and colistin-resistant E. coli.
International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil.
The study identified various AMR genes in CTX-M-producing E. coli isolates from peri-urban wild animals in Brazil, including bla CTX-M-55, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, and others, indicating the presence of multidrug-resistant bacteria in wildlife.
Genomic Analysis of GC1 Strains from H1 Hospital
The study identifies various AMR genes in GC1 Group 1 and Outgroup Group 3 genomes, including aac(6')-Ib, aph(3')-Ia, aac(3)-IIa, sul1, sul2, tet(A), tet(G), catA1, intI1, intI2, and efflux pumps adeABC, adeIJK, and adeFGH. These genes contribute to multidrug resistance in Acinetobacter baumannii.
Accumulation of Antibiotic Resistance Genes in Carbapenem-Resistant Acinetobacter baumannii Isolates Belonging to Lineage 2, Global Clone 1, from Outbreaks in 2012-2013 at a Tehran Burns Hospital.
The study identifies multiple antibiotic resistance genes, including blaOXA-23, blaOXA-24, aadB, sul2, aphA6, and tet39, in carbapenem-resistant Acinetobacter baumannii isolates from Iran, highlighting the genetic basis of multidrug resistance in these strains.
Systematic Evaluation of Whole Genome Sequence-Based Predictions of Salmonella Serotype and Antimicrobial Resistance.
The study evaluated the performance of various bioinformatics tools for predicting antimicrobial resistance (AMR) and serotypes of Salmonella enterica using whole-genome sequencing (WGS). It identified several AMR genes and mutations associated with resistance to various antibiotics.
Antimicrobial resistance of Escherichia coli isolated from retail foods in northern Xinjiang, China.
The study identified various antimicrobial resistance genes in Escherichia coli isolates from retail foods in northern Xinjiang, China, including tetA, tetB, blaOXA, blaTEM, floR, sul1, sul2, aadAla, aadB, strA, and strB. These genes conferred resistance to tetracycline, beta-lactams, chloramphenicol, sulfonamides, and streptomycin.
Antimicrobial resistance of Escherichia coli isolated from retail foods in northern Xinjiang, China.
The study identified various antimicrobial resistance genes in Escherichia coli isolates from retail foods in northern Xinjiang, China, including tetA, tetB, blaOXA, blaTEM, floR, sul1, sul2, aadAla, aadB, strA, and strB. These genes conferred resistance to tetracycline, beta-lactams, chloramphenicol, sulfonamides, and streptomycin.
Extensively Drug-resistant Acinetobacter baumannii Belonging to International Clone II from A Pet Cat with Urinary Tract Infection; The First Report from Pakistan.
Pathotypes and Antimicrobial Susceptibility of Escherichia Coli Isolated from Wild Boar (Sus scrofa) in Tuscany.
The study identified various antimicrobial resistance genes in E. coli isolates from wild boar in Tuscany, including blaCMY-2, sul1, sul2, tetG, aadA1, and strA-strB, indicating significant resistance to beta-lactams, sulfonamides, tetracyclines, and streptomycin.
Co-occurrence of mcr-1, mcr-3, mcr-7 and clinically relevant antimicrobial resistance genes in environmental and fecal samples.
The study identified the co-occurrence of mcr-1, mcr-3, mcr-7.1, and various clinically relevant antimicrobial resistance genes in environmental and fecal samples from a Brazilian zoo, highlighting the potential reservoir of these genes in zoological environments.
Highly Transferable pAQU-Related Plasmids Encoding Multidrug Resistance Are Widespread in the Human and Fish Pathogen Photobacterium damselae subsp. damselae in Aquaculture Areas in the Black Sea.
The study identifies multiple multidrug resistance plasmids in Photobacterium damselae subsp. damselae, including novel versions of pAQU-group plasmids carrying resistance genes such as tetB, floR, sul2, qnrVC, dfrA, and strAB.
Klebsiella pneumoniae carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors.
The study identified various AMR genes and mutations in Klebsiella pneumoniae isolates from pregnant women in low-income countries, highlighting the prevalence of multidrug-resistant strains and the role of environmental factors in their carriage.
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
The study identified several AMR genes and mutations in Salmonella Typhi isolates, including beta-lactamases (blaTEM-1B, blaTEM-116), chloramphenicol resistance gene (catA1), trimethoprim resistance genes (dfrA7, dfrA15), sulfamethoxazole resistance genes (sul1, sul2), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE genes.
Nanopore sequencing reveals genomic map of CTX-M-type extended-spectrum β-lactamases carried by Escherichia coli strains isolated from blue mussels (Mytilus edulis) in Norway.
The study identified CTX-M-type extended-spectrum beta-lactamases in Escherichia coli strains isolated from blue mussels in Norway, highlighting the potential for mobility of these resistance genes.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Mobile Genetic Elements Harboring Antibiotic Resistance Determinants in Acinetobacter baumannii Isolates From Bolivia.
The study identified multiple antibiotic resistance genes in Acinetobacter baumannii isolates from Bolivia, including bla OXA-23, strA, strB, aac(3)-IIa, aac(6')-Ian, sul2, tet(B), bla TEM-1B, and aadB, which contribute to resistance against carbapenems, aminoglycosides, sulfonamides, tetracycline, and beta-lactams.
Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines.
The study identifies various carbapenemase genes such as blaNDM-1, blaNDM-7, blaCTX-M-15, and blaOXA-181, along with other AMR genes like rmtC, sul1, aac(6')-Ib-cr, mph(A), qnrB1, and others, which contribute to resistance against multiple antibiotics in Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa in the Philippines.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Whole Genome Sequencing Analysis of Porcine Faecal Commensal Escherichia coli Carrying Class 1 Integrons from Sows and Their Offspring.
The study identified multiple antimicrobial resistance genes in porcine faecal commensal E. coli, including blaTEM-1, strA, strB, tetA, dfrA12, aadA1, aadA2, cmlA, aph(3')-Ia, sul2, and sul3, which confer resistance to beta-lactams, streptomycin, tetracyclines, trimethoprim, aminoglycosides, chloramphenicol, neomycin, kanamycin, and sulfonamides.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Genomic characterization of multidrug-resistant ESBL-producing Escherichia coli ST58 causing fatal colibacillosis in critically endangered Brazilian merganser (Mergus octosetaceus).
The study identifies a multidrug-resistant ESBL-producing E. coli ST58 strain (PMPU) isolated from a critically endangered Brazilian merganser, carrying genes conferring resistance to various antibiotics, heavy metals, and disinfectants, along with fluoroquinolone resistance mutations.
Genomic Characterisation of a Multiple Drug Resistant IncHI2 ST4 Plasmid in Escherichia coli ST744 in Australia.
The study describes the first complete sequence of a multiple drug-resistant IncHI2 ST4 plasmid, pTZ41_1P, from a commensal E. coli in Australia. The plasmid carries genes conferring resistance to heavy metals, beta-lactams, aminoglycosides, and sulfonamides.
Reservoirs of antimicrobial resistance genes in retail raw milk.
The study identifies multiple antimicrobial resistance genes in retail raw milk, including bla CMY-2, aph (3')-Ib, aph (6)-Id, bla TEM-1B, mdf(A), catA2, sul2, tet(B), and dfrA14, which confer resistance to various antibiotics. These genes were found in E. coli and other bacteria, and some were transferable between species.
Detection of Extended-Spectrum β-Lactamases (ESBL) Producing Enterobacteriaceae from Fish Trapped in the Lagoon Area of Bizerte, Tunisia.
The study identified several β-lactamase genes (bla CTX-M-1, bla CTX-M-15, bla CTX-M-9, bla OXA-1, and bla TEM-1-a) and other resistance genes (sul1, sul2, tetA, aac(6')-Ib-cr, qnrA, and qnrB) in ESBL-producing Enterobacteriaceae isolated from fish in the Bizerte lagoon, highlighting the presence of multidrug-resistant bacteria in aquatic environments.
Structural Genomics of repA, repB 1-Carrying IncFIB Family pA1705-qnrS, P911021-tetA, and P1642-tetA, Multidrug-Resistant Plasmids from Klebsiella pneumoniae.
The study characterizes multidrug-resistant plasmids pA1705-qnrS, p911021-tetA, and p1642-tetA from Klebsiella pneumoniae, identifying several AMR genes including beta-lactamases (bla CTX-M-14, bla TEM-1, bla OXA-1, bla SHV-12, bla CTX-M-15, bla CTX-M-65), quinolone resistance gene qnrS1, tetracycline resistance genes tetA (A) and tetA (D), aminoglycoside resistance genes aacA4cr and aacC2, streptomycin resistance genes strA and strB, dihydrofolate reductase genes dfrA1 and dfrA14, sulfonamide resistance gene sul2, macrolide resistance gene mph (A), efflux pump gene oqxAB, chloramphenicol acetyltransferase gene catB3, and tunicamycin resistance gene tmrB.
Whole-genome sequence analyses of Glaesserella parasuis isolates reveals extensive genomic variation and diverse antibiotic resistance determinants.
The study identified several antibiotic resistance genes in Glaesserella parasuis, including bla ROB−1, aac(6′)-Ie-aph(2″)-Ia, sul2, aph(3′)-Ib, norA, bacA, ksgA, and bcr, which contribute to resistance against beta-lactams, aminoglycosides, sulfonamides, fluoroquinolones, and multiple antibiotics.
Genomic analyses of multidrug-resistant Salmonella Indiana, Typhimurium, and Enteritidis isolates using MinION and MiSeq sequencing technologies.
The study identified various AMR genes in multidrug-resistant Salmonella isolates, including beta-lactamases (blaCTX-M-14, blaCTX-M-27, blaCTX-M-55, blaOXA-1, blaCMY-2, blaOXA, blaCMY), phenicol resistance genes (catB3, cmlA1, floR, catA1, catA2, oqxA, oqxB), aminoglycoside resistance genes (aac(6')-Ib-cr5, aac(6')-Ib-cr, oqxA2, qepA1, qnrS1), sulfonamide and trimethoprim resistance genes (sul1, sul2, sul3, dfrA12, dfrA7), and tetracycline resistance genes (tet(A), tet(B), tet(M)).
Molecular characteristics of fluoroquinolone-resistant avian pathogenic Escherichia coli isolated from broiler chickens.
The study identified several AMR genes and mutations in fluoroquinolone-resistant avian pathogenic Escherichia coli (APEC) isolates, including qnrA, qnrS, blaCTX-1, blaCTX-15, blaTEM-1, aac(3)-II, tetA, sul1, sul2, and catA1, along with mutations in gyrA and parC that confer fluoroquinolone resistance.
Antimicrobial Resistance in Swine Fecal Specimens Across Different Farm Management Systems.
The study identified several AMR genes associated with different antimicrobial classes in swine fecal samples from farms with varying antimicrobial usage levels. These genes included beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, macrolide resistance markers, polymyxin resistance genes, phenicol resistance genes, and trimethoprim resistance genes.
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The study identified multiple AMR genes, including bla CTX-M-55, bla CMY-2, bla CTX-M-1, bla SHV-12, sul2, aac(3)-Ia, aadA, strA, strB, tet(A), tet(B), dfrA14, floR, cmlA1, catA1, catB3, qnrS1, qnrS2, qnrB19, mph(A), mph(B), arr-3, and aac(6')Ib-cr, in ESBL/pAmpC-producing E. coli isolates from broiler production.
What do we know about plasmids carried by members of the Acinetobacter genus?
The paper reviews the diversity and characteristics of plasmids in Acinetobacter species, particularly highlighting the presence of various beta-lactamase genes (blaOXA-23, blaOXA-58, blaOXA-24, blaPER-1, blaADC-25), aminoglycoside resistance genes (aadB, aphA6), tetracycline resistance gene (tet(39)), macrolide resistance genes (mph(E), msr(E)), sulfonamide resistance gene (sul2), and other resistance genes (bcr). These genes are primarily found on plasmids and contribute to multidrug resistance in clinical isolates.
Tracking Recombination Events That Occur in Conjugative Virulence Plasmid p15WZ-82_Vir during the Transmission Process.
The study characterizes the recombination events in the conjugative virulence plasmid p15WZ-82_Vir during transmission, identifying multiple antibiotic resistance genes and their roles in the formation of mosaic plasmids that carry both virulence and resistance traits.
Whole-Genome-Based Survey for Polyphyletic Serovars of Salmonella enterica subsp. enterica Provides New Insights into Public Health Surveillance.
The study identifies antimicrobial resistance (AMR) profiles in specific lineages of Salmonella enterica subsp. enterica serovars, highlighting the presence of resistance genes such as aac(6')-Ib, aph(3')-Ib, sul2, and tet(A) in host-preferred lineages, indicating that AMR profiles are lineage-specific and associated with niche preference.
Emerging Antimicrobial-Resistant High-Risk Klebsiella pneumoniae Clones ST307 and ST147.
The study identifies and characterizes the antimicrobial resistance genes and mutations associated with the high-risk Klebsiella pneumoniae clones ST307 and ST147, highlighting their global spread and the diversity of resistance mechanisms they employ.
Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment.
This review discusses the mechanisms that protect Acinetobacter baumannii against multiple stresses, including those from the host immune response, antibiotics, and the outside environment. It highlights the role of surface glycoconjugates, outer membrane components, and various virulence factors in evading immune defenses and surviving adverse conditions.
Occurrence and Antimicrobial Resistance Traits of Escherichia coli from Wild Birds and Rodents in Singapore.
F Plasmids Are the Major Carriers of Antibiotic Resistance Genes in Human-Associated Commensal Escherichia coli.
The study identifies various antibiotic resistance genes in commensal E. coli isolates, highlighting the prevalence of resistance genes on F plasmids and the role of mobile genetic elements in their dissemination.
Identification of a Cluster of Extended-spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Sequence Type 101 Isolated From Food and Humans.
The study identifies a cluster of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae sequence type 101 isolated from food and humans, highlighting the potential role of food as a source of multidrug-resistant bacteria transmission to humans.
Antibiotic Susceptibility Testing (AST) Reports: A Basis for Environmental/Epidemiological Surveillance and Infection Control Amongst Environmental Vibrio cholerae.
The study identified various antibiotic resistance genes in Vibrio cholerae isolates, including blaTEM, NDM-1, AmpC, and ESBL, indicating multidrug resistance in environmental V. cholerae.
Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study.
The study identified 55 different antimicrobial resistance determinants in diarrheal pathogens, highlighting the presence of genes conferring resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, macrolides, tetracyclines, phenicols, sulfonamides, and others. Notably, carbapenemase genes like bla OXA-48 and bla NDM were detected in certain isolates, indicating emerging resistance concerns.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Molecular Characterization of a Novel Integrative Conjugative Element ICEHpa1 in Haemophilus parasuis.
The study identifies a novel integrative conjugative element, ICE Hpa1, carrying seven distinct resistance genes in Haemophilus parasuis, highlighting its role in multidrug resistance.
Occurrence and Characterization of Salmonella Isolated From Chicken Breeder Flocks in Nine Chinese Provinces.
The study identified the presence of bla TEM, sul3, sul2, and aaC4 genes in Salmonella isolates from chicken breeder flocks in China, contributing to resistance against ampicillin, cefoxitin, ceftriaxone, sulfamethoxazole, and streptomycin.
Genomic insights of Klebsiella pneumoniae isolated from a native Amazonian fish reveal wide resistome against heavy metals, disinfectants, and clinically relevant antibiotics.
The study identifies a multidrug-resistant Klebsiella pneumoniae strain carrying several AMR genes, including blaCTX-M-15, blaTEM-1B, blaSHV-27, aac(3)-IId, aadA1, sul2, tetB, tetD, fosA-like, oqxA, oqxB, and qnrE1, highlighting the potential of native Amazonian fish as reservoirs of clinically relevant AMR genes.
Pyrolyzed biowastes deactivated potentially toxic metals and eliminated antibiotic resistant genes for healthy vegetable production.
The study found that pyrolysis of biowastes effectively reduced the abundance of antibiotic resistance genes (ARGs) such as tetracycline resistance genes (tetC, tetG, tetM, tetO, tetW), sulfonamide resistance genes (sul1, sul2), and class 1 integron-integrase gene (intI1) in swine manure and sewage sludge.
Molecular Characteristics and Zoonotic Potential of Salmonella Weltevreden From Cultured Shrimp and Tilapia in Vietnam and China.
The study identified aminoglycoside resistance gene aac(6')-Iaa, streptomycin resistance genes strA and strB, sulfonamide resistance gene sul2, tetracycline resistance gene tet(A), and a quinolone resistance mutation in parC (p.T57S) in Salmonella Weltevreden isolates from shrimp and tilapia in Vietnam and China.
Genomic analysis reveals high virulence and antibiotic resistance amongst phage susceptible Acinetobacter baumannii.
The study identified multiple antibiotic resistance genes in phage-susceptible Acinetobacter baumannii strains, including sulfonamide, tetracycline, beta-lactam, aminoglycoside, macrolide, and phenicol resistance genes. These findings highlight the complex resistance profiles of these strains and their potential implications for therapeutic strategies.
Genome Characterization of mcr-1-Positive Escherichia coli Isolated From Pigs With Postweaning Diarrhea in China.
The study identifies multiple antimicrobial resistance genes, including mcr-1.1 and mcr-3.1, in multidrug-resistant E. coli isolates from pigs with postweaning diarrhea in China.
The New Klebsiellapneumoniae ST152 Variants with Hypermucoviscous Phenotype Isolated from Renal Transplant Recipients with Asymptomatic Bacteriuria-Genetic Characteristics by WGS.
The study identified several AMR genes in two hypermucoviscous Klebsiella pneumoniae isolates from renal transplant recipients, including bla CTX-M-15, aac(6')-Ib-cr, and others, indicating resistance to various antibiotics.
A Multidrug-resistant Monophasic Salmonella Typhimurium Co-harboring mcr-1, fosA3, bla (CTX-M-14) in a Transferable IncHI2 Plasmid from a Healthy Catering Worker in China.
Prevalence and antibiotic susceptibility of Mannheimia haemolytica and Pasteurella multocida isolated from ovine respiratory infection: A study from Karnataka, Southern India.
The study identified antibiotic resistance genes such as strA (32.7%) and sul2 (32.7%) associated with streptomycin and sulfonamide resistance, respectively, in M. haemolytica and P. multocida isolates.
Genomic Characterization of Salmonella Minnesota Clonal Lineages Associated with Poultry Production in Brazil.
The study identified multiple antimicrobial resistance genes, including aac(6')-Iaa, mdf(A), sul2, tet(A), blaCMY-2, aph(3')-Ia_1, qnrB19, and ant(3'')-Ia, in Salmonella Minnesota isolates from Brazilian poultry farms, indicating widespread resistance to various antibiotics.
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
The study identified multiple antimicrobial resistance genes (ARGs) and mutations in Escherichia coli isolates from various sources in Italy, highlighting the prevalence of resistance to tetracycline, sulfonamide, penicillin, fluoroquinolone, and colistin. Key genes included tetA, sul2, blaTEM-1b, mcr-1, qnrS1, and others, along with mutations in gyrA, parC, parE, and pmrB.
Genome-based characterization of two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases.
Two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases were characterized. The isolates exhibited resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.
A Multifactorial Approach for Surveillance of Shigella spp. and Entero-Invasive Escherichia coli Is Important for Detecting (Inter)national Clusters.
The study identified several AMR genes and mutations in Shigella spp. and EIEC isolates, including beta-lactamases (blaTEM-1b, blaOXA-1, blaCTX-M-15, blaCTX-M-32, blaCTX-M-55, blaDHA-1), dihydrofolate reductase variants (dfrA1, dfrA14, dfrA17, dfrA7, dfrA8), sulfonamide resistance genes (sul1, sul2), macrolide resistance genes (erm(B), mphA), and chromosomal mutations in gyrA, parC, and parE associated with ciprofloxacin resistance.
Employing MIC Data for Mink Pathogens to Propose Tentative Epidemiological Cut-Off Values: A Step Toward Rationalizing Antimicrobial Use in Mink.
The study identified several AMR genes in mink pathogens, including beta-lactamases (blaTEM-1, blaCTX-M-1), tetracycline resistance genes (tet(A), tet(B)), aminoglycoside resistance genes (aadA5, aadA1), sulfonamide resistance genes (sul2), dihydrofolate reductase genes (dfrA1, dfrA5, dfrA8, dfrA14), macrolide/lincosamide/streptogramin B resistance genes (erm), lincomycin resistance gene (lnu(A)), spectinomycin resistance gene (spc), and additional sulfonamide and trimethoprim resistance genes (sul1, sul3, dfrK, dfrG).
The importance of using whole genome sequencing and extended spectrum beta-lactamase selective media when monitoring antimicrobial resistance.
The study highlights the utility of whole genome sequencing (WGS) in monitoring antimicrobial resistance (AMR) trends, particularly in identifying ESBL genes such as bla CTX-M-1, bla CTX-M-15, bla SHV-12, bla CMY-2, and bla DHA-1, along with other resistance genes like sul2, tet(A), dfrA17, aadA5, ant3-1a, strA, strB, and fosA3 in E. coli isolates from pig surveillance.
Salmonella identified in pigs in Kenya and Malawi reveals the potential for zoonotic transmission in emerging pork markets.
The study identified several AMR genes in Salmonella isolates from pigs in Kenya and Malawi, including dfrA14, sul2, aph(3''-1b), aph(6)-1d, blaTEM-1B, fosA7, tet(A), and tet(J). A single isolate with a gyrA(D87Y) mutation showed resistance to pefloxacin.
Whole-Genome Sequence Analysis of an Extensively Drug-Resistant Salmonella enterica Serovar Agona Isolate from an Australian Silver Gull (Chroicocephalus novaehollandiae) Reveals the Acquisition of Multidrug Resistance Plasmids.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Salmonella enterica serovar Agona isolate from a silver gull, including bla CTX-M-55, dfrA14, sul3, qnrS1, tet(A), bla TEM-1, and others, indicating the acquisition of multidrug resistance plasmids.
Does Shiga Toxin-Producing Escherichia coli and Listeria monocytogenes Contribute Significantly to the Burden of Antimicrobial Resistance in Uruguay?
The study identified several antimicrobial resistance genes in Shiga toxin-producing Escherichia coli (STEC) and Listeria monocytogenes isolates, including aph(3")-Ib, aph(3′)-Ia, aph(6)-Id, blaTEM-1B, sul2, tet(A), fosX, lin, norB, lde, mdrL, and fepA. These genes conferred resistance to various antibiotics such as ampicillin, trimethoprim-sulfamethoxazole, tetracycline, fosfomycin, lincomycin, ciprofloxacin, and erythromycin.
Analysis of Complete Genome Sequence of Acinetobacter baumannii Strain ATCC 19606 Reveals Novel Mobile Genetic Elements and Novel Prophage.
The study identifies the sul2 sulfonamide resistance gene and the intrinsic ant(3")-IIa aminoglycoside resistance gene in Acinetobacter baumannii strain ATCC 19606, confirming its resistance to sulfamethoxazole, streptomycin, and spectinomycin.
Molecular Epidemiology of Antibiotic-Resistant Escherichia coli from Farm-To-Fork in Intensive Poultry Production in KwaZulu-Natal, South Africa.
The study identified the presence of bla CTX-M, sul1, tetA, and tetB genes in Escherichia coli isolates from various stages of the farm-to-fork continuum in intensive poultry production in South Africa.
Antimicrobial Resistance and Genomic Characterization of OXA-48- and CTX-M-15-Co-Producing Hypervirulent Klebsiella pneumoniae ST23 Recovered from Nosocomial Outbreak.
The study characterizes the AMR genes in a multidrug-resistant hypervirulent Klebsiella pneumoniae ST23 isolate, MAR14-456, which co-produces OXA-48 and CTX-M-15. The isolate shows resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.
Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species.
Four tet(X) variants (tet(X3), tet(X4), tet(X5.2), and tet(X5.3)) were identified in Acinetobacter species, showing high-level resistance to tigecycline, tetracycline, eravacycline, and omadacycline. These genes were found in multiple Acinetobacter species and were associated with IS CR2 elements, facilitating their spread.
Analysis of existence of multidrug-resistant H58 gene in Salmonella enterica serovar Typhi isolated from typhoid fever patients in Makassar, Indonesia.
Clinical and microbiological characteristics of patients colonized or infected by Stenotrophomonas maltophilia : is resistance to sulfamethoxazole/trimethoprim a problem?
The study identified the sul1, sul2, and dfrA1 genes as key mechanisms of sulfamethoxazole/trimethoprim resistance in Stenotrophomonas maltophilia, with sul1 being the most prevalent.
Genomic epidemiology of Escherichia coli isolates from a tertiary referral center in Lilongwe, Malawi.
The study identifies the blaCTX-M-15 gene as a major contributor to cephalosporin resistance in Escherichia coli isolates from Malawi, along with other AMR genes such as aac(3)-IIa, aac(3)-IId, aadA5, ant(3'')-Ih, aph(3'')-Ib, aph(3')-Ia, aph(6)-Id, strA, strB, acrF, emrD, mdtM, blaTEM-1, catA1, catB3, dfrA17, sul2, mph(A), and tet(A).
A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length, and Genomic Positions.
The study identifies several antimicrobial resistance (AMR) genes encoded in prophages within Acinetobacter baumannii genomes, including blaOXA-23, blaNDM-1, blaADC-5, blaOXA-67, blaOXA-115, blaTEM-12, aac(3)-I, aac(3)-Id, aacA16, aph(3')-Ia, aph(3')-VI, aph(6)-Id, aph(3'')-Ib, msr(E), mph(E), and sul2. These genes confer resistance to various antibiotics such as carbapenems, penicillins, cephalosporins, monobactams, aminoglycosides, macrolides, and sulfonamides.
Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid.
The study identifies the blaCTX-M-1 gene carried on an IncI1/ST3 plasmid in Enterobacter cloacae and Escherichia coli isolates from humans and wild animals in Guadeloupe, highlighting the dissemination of this resistance determinant in the environment.
A Novel Mobile Element ICERspD18B in Rheinheimera sp. D18 Contributes to Antibiotic and Arsenic Resistance.
The study characterizes the novel integrative and conjugative element ICE Rsp D18B in Rheinheimera sp. D18, which contains six antibiotic resistance genes (floR, sul2, strB, aph(3'')-Ib, and others) and an arsenic tolerance operon (arsRHCB), contributing to resistance against antibiotics and arsenic compounds.
Colistin-resistant Enterobacter kobei carrying mcr-9.1 and bla(CTX-M-15) infecting a critically endangered franciscana dolphin (Pontoporia blainvillei), Brazil.
The study reports the emergence of the mcr-9.1 gene in a colistin-resistant Enterobacter kobei strain isolated from a critically endangered franciscana dolphin in Brazil, along with various other AMR genes.
Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica.
The study identified several β-lactamase genes, including bla CTX-M-5, bla OXA-1, bla CTX-M-15, bla CTX-M-3, and bla TEM-1, which contribute to extended-spectrum β-lactamase (ESBL) production in multidrug-resistant non-typhoidal Salmonella enterica isolates. Additionally, a mutation in the gyrA gene (D87N) was linked to quinolone resistance.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Antimicrobial Resistance in Escherichia coli Strains Isolated from Humans and Pet Animals.
The study identifies several AMR genes in E. coli strains isolated from humans and pet animals, including blaTEM, qnrS1, qnrB1, blaCMY-2, blaCMY-59, tetA, tetB, sul1, sul2, and sul3, which confer resistance to various antibiotics such as beta-lactams, quinolones, tetracyclines, and sulfonamides.
Molecular characterisation of extended-spectrum ß-lactamase producing Escherichia coli in wild birds and cattle, Ibadan, Nigeria.
The study identified various AMR genes in ESBL-producing E. coli from wild birds and cattle in Nigeria, including bla CTX-M1/15, bla CTX-M9, strB, sul2, tetA, and others. These genes were associated with resistance to multiple antibiotics, highlighting the potential for inter-species transmission of AMR bacteria.
Antibiotic resistance plasmid composition and architecture in Escherichia coli isolates from meat.
The study characterizes various AMR genes in plasmids from meat-derived E. coli isolates, highlighting the diversity and clustering of resistance genes such as bla CTX-M-1, aadA5, sul2, and others, along with their association with specific plasmid incompatibility groups.
Higher prevalence of multidrug-resistant extended-spectrum β-lactamases producing Escherichia coli in unorganized pig farms compared to organized pig farms in Mizoram, India.
The study identified several AMR genes, including bla TEM, bla CTX-M, bla CMY, tetA, tetB, sul1, sul2, aadA, and dfrIa, in multidrug-resistant E. coli isolates from both organized and unorganized pig farms in Mizoram, India.
Characterization of Enterococci- and ESBL-Producing Escherichia coli Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified several AMR genes in Enterococcus and ESBL-producing E. coli isolates from bovine mastitis cases in Egypt, including erm(B), tetL, aac-aphD, vanA, and vanB.
Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates from Jurong Lake, Singapore with Whole-Genome-Sequencing.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-8, bla CTX-M-27, bla CTX-M-14, and bla CTX-M-55, along with mcr-1.1 and mcr-3.1 for colistin resistance. Additionally, various other resistance genes such as qnrS1, mdf(A), mph(A), and others were found in the isolates, indicating multidrug resistance.
Complete Genome Sequencing of Acinetobacter baumannii AC1633 and Acinetobacter nosocomialis AC1530 Unveils a Large Multidrug-Resistant Plasmid Encoding the NDM-1 and OXA-58 Carbapenemases.
The study identifies a large multidrug-resistant plasmid in Acinetobacter baumannii AC1633 and Acinetobacter nosocomialis AC1530 carrying the NDM-1 and OXA-58 carbapenemases, along with other resistance genes such as aac(3)-IId, aph(6)-Id, aph(3")-Ib, sul2, msrE, mphE, and tetA(39).
Resistome of a carbapenemase-producing novel ST232 Klebsiella michiganensis isolate from urban hospital effluent in South Africa.
The study reports the first carbapenemase-producing Klebsiella michiganensis isolate from South African hospital effluent, harboring multiple resistance genes including blaOXA-181, blaOXY-5-1, qnrB6, qnrS1, aadA16, aac(6')-Ib-cr, aph(6)-Id, arr-3, sul1, sul2, dfrA14, and dfrA27.
Resistance determinants and their genetic context in enterobacteria from a longitudinal study of pigs reared under various husbandry conditions.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, and bla CMY-2, which confer resistance to various beta-lactam antibiotics in enterobacteria from pigs. Additionally, bla IMP-7 was found to confer resistance to carbapenems in Providencia rettgeri.
Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya.
The study identified several AMR genes in Salmonella isolates from Kenya, including blaTEM-1, aadA1, strA, strB, catA1, dhfr1, sul1, and sul2, which confer resistance to various antibiotics such as penicillins, cephalosporins, streptomycin, chloramphenicol, trimethoprim, and sulfonamides.
Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?
The study identifies multiple AMR genes in endophytic ESBL-producing Enterobacterales isolated from fresh vegetables, highlighting their potential role in the spread of antibiotic resistance.
Genome-wide genetic marker analysis and genotyping of Escherichia fergusonii strain OTSVEF-60.
The study identified multiple antimicrobial resistance genes in Escherichia fergusonii strain OTSVEF-60, including aadA2, blaTEM-1, dfrA12, qnrS1, sul1, sul2, and tet(A), which confer resistance to aminoglycosides, beta-lactams, diaminopyrimidines, fluoroquinolones, sulfonamides, and tetracyclines.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya.
The study identified various carbapenemase genes (blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-6, blaOXA-23, blaOXA-58, blaOXA-66, blaOXA-69, blaOXA-91, blaOXA-181, blaOXA-50) and other resistance genes (such as armA, rmtC, rmtF, aac(3)-I, aadA1, aph(3')-Ia, aph(3')-VI, aph(3')-Via, aph(6')-Id, mphE, msrE, mphA, ereA, dfrA1, dfrA12, dfrA14, dfrA17, dfrA20, sul1, sul2, tetB, tetD, tetG, tet39, qnrVC1, qnrS1, qnrB4, floR, catA1, catA2, catB3, catB7, cmlA1, cmlA5, arr-3, arr-2, sat2, acrF, mdtM, emrD, mexA, mexE, mexX, kdeA, oxa-10, oxa-395, oxa-396, oxa-846, adc-25, dha-1, act-16, cmY, ctx-m-15, shv-67, tem-1b) in carbapenem non-susceptible clinical isolates of gram-negative bacteria in Kenya, highlighting the diversity and prevalence of multidrug resistance.
Utility of whole-genome sequencing during an investigation of multiple foodborne outbreaks of Shigella sonnei.
The study identified multiple antimicrobial resistance genes in the Shigella sonnei outbreak strain, including blaCTX-M-15, qnrS1, strA, strB, dfrA1, tetA, and sul2, which conferred resistance to various antibiotics such as ceftazidime, ciprofloxacin, streptomycin, trimethoprim, tetracycline, and sulfamethoxazole.
Wild Boars Carry Extended-Spectrum β-Lactamase- and AmpC-Producing Escherichia coli.
Wild boars in Germany carry ESBL/AmpC-producing E. coli, with bla CTX-M-1, bla SHV-12, and bla CMY-2 being the most common beta-lactamase genes. Additional resistance genes include sul1, sul2, sul3, dfrA1, dfrA5, dfrA14, dfrA17, tet(A), cmlA, floR, and qnrS.
Correlation between the sulfamethoxazole-trimethoprim resistance of Shigella flexneri and the sul genes.
The study found that the sul1 and sul2 genes are strongly correlated with sulfamethoxazole-trimethoprim resistance in Shigella flexneri isolates.
Institutional outbreak involving multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 at a cancer center in Tokyo, Japan.
The study identified multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 (ST78) strains causing an institutional outbreak. These strains carried blaIMP-1 and blaIMP-11 genes on IncHI2 and IncL/M plasmids, along with various other resistance genes such as aac(6')-IIc, qnrB6, fosA, sul1, and tet(B).
Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance in Escherichia coli from German Broiler Fattening Farms.
The study identified various AMR genes in E. coli isolates from German broiler farms, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-1C, blaCTX-M-1, blaCMY-2), quinolone resistance genes (qnrB19, qnrS1), chloramphenicol resistance gene (cat1), tetracycline resistance genes (tetA, tetB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase genes (drfA1, drfA5, drfA14, drfA17), aminoglycoside resistance gene (aadA1), and efflux pump genes (sugEp, qacEΔ1, mdfA).
Antimicrobial Resistance Genes and Diversity of Clones among ESBL- and Acquired AmpC-Producing Escherichia coli Isolated from Fecal Samples of Healthy and Sick Cats in Portugal.
The study identified various ESBL and qAmpC genes in E. coli isolates from cats, highlighting the presence of bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-27, bla CTX-M-9, bla TEM, bla SHV-28, and bla CMY-2, along with other resistance genes such as tet(A), tet(B), sul1, sul2, aac(6')-Ib-cr, and armA.
Antimicrobial Resistance Profile and ExPEC Virulence Potential in Commensal Escherichia coli of Multiple Sources.
The study identified several AMR genes, including blaCTX-M, mcr-1, and qnrS1, which confer resistance to cephalosporins, colistin, and fluoroquinolones, respectively, in commensal E. coli from various sources.
Genomic diversity and molecular epidemiology of Pasteurella multocida.
This study identified several antimicrobial resistance genes in Pasteurella multocida, including aminoglycoside, beta-lactam, tetracycline, macrolide, and sulfonamide resistance genes, highlighting the diverse resistance mechanisms present in this pathogen.
Emergence of High Level Carbapenem and Extensively Drug Resistant Escherichia coli ST746 Producing NDM-5 in Influent of Wastewater Treatment Plant, Seoul, South Korea.
The study reports the emergence of a high-level carbapenem-resistant and extensively drug-resistant (XDR) Escherichia coli strain N7 producing NDM-5, highlighting the presence of multiple resistance genes on plasmids and chromosomes.
Evaluation of commercial probiotics for antimicrobial resistance genes.
The study found that 94% of the evaluated commercial probiotics contained at least one transferable antimicrobial resistance (AMR) gene, with 82% containing two or more. The most commonly detected AMR genes were tetK (68%) and sul2 (60%).
Genomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-Producing Escherichia coli Strains From Healthy Food Animals Across Europe.
The study identifies various ESBL and AmpC beta-lactamase genes, including bla SHV-12, bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla CTX-M-15, bla TEM-52, and bla CMY-2, along with the mcr-1 gene conferring colistin resistance in E. coli isolates from food animals in Europe.
Genomic Characterization of Salmonella enterica Isolates From Retail Meat in Beijing, China.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from retail meat in Beijing, including beta-lactamases (blaCTX-M-55, blaCTX-M-14, blaCTX-M-65), aminoglycoside resistance genes (aac(6')-Iaa, aph(6)-Id, aph(3")-Ib), sulfonamide resistance gene (sul2), beta-lactamase (blaTEM-1B), quinolone resistance genes (qnrS1), and colistin resistance genes (mcr-1.1, mcr-9).
Antimicrobial Resistance Genes in ESBL-Producing Escherichia coli Isolates from Animals in Greece.
The study identified several AMR genes in ESBL-producing E. coli isolates from animals in Greece, including bla CTX-M-1/15, bla TEM, aadA1, aadA2, aphA, strA, strB, sul1, sul2, sul3, dfrA1, dfrA5, dfrA7, dfrA12, dfrA14, dfrA15, dfrA17, dfrA19, mph, mrx, intI1, tnpISE cp1, qnrS, and qnrB.
A Real-Time Thermal Sensor System for Quantifying the Inhibitory Effect of Antimicrobial Peptides on Bacterial Adhesion and Biofilm Formation.
The study identified several AMR genes in E. coli and S. aureus isolates, including beta-lactamases (blaOXA-1, blaTEM-1A), chloramphenicol acetyltransferase (catA1), trimethoprim resistance gene (dfrA1), fluoroquinolone resistance gene (floR), sulfonamide resistance genes (sul1, sul2), methicillin resistance gene (mecA), beta-lactamase (blaZ-like), and tetracycline efflux pumps (tet(K), tet(M)).
On-Farm Anaerobic Digestion of Dairy Manure Reduces the Abundance of Antibiotic Resistance-Associated Gene Targets and the Potential for Plasmid Transfer.
The study found that anaerobic digestion of dairy manure significantly reduced the abundance of antibiotic resistance genes, including various ESBL genes such as bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, and bla PER-1, as well as other resistance genes like aac(6')-Ib-cr, aph(3')-Ib, aph(6)-Id, bla OXA-1, catB4, dfrA1, floR, lnu(G), sul2, aadA2, mph(E), msr(E), tet(C), tet(E), and tet(X).
Frequency, Local Dynamics, and Genomic Characteristics of ESBL-Producing Escherichia coli Isolated From Specimens of Hospitalized Horses.
The study identified several ESBL genes, including blaCTX-M-1, blaCTX-M-15, blaSHV-12, blaOXA-1, blaCTX-M-14, blaCTX-M-3, and blaCMY-2, along with aminoglycoside resistance genes like aac(3)-IV, sulfonamide resistance genes sul1 and sul2, and trimethoprim resistance genes dfrA and dfrG, in ESBL-producing E. coli isolates from hospitalized horses.
Multidrug-resistant Klebsiella pneumoniae harboring extended spectrum β-lactamase encoding genes isolated from human septicemias.
The study identified multiple beta-lactamase genes including bla CTX-M-15, bla SHV-1, bla SHV-11, bla SHV-27, bla SHV-106, and bla TEM, along with carbapenemase genes bla KPC2/3 and bla OXA-48, contributing to multidrug resistance in Klebsiella pneumoniae isolates from human septicemias.
Characterization of beta-lactam-resistant Escherichia coli from Australian fruit bats indicates anthropogenic origins.
The study identified various beta-lactam-resistant Escherichia coli strains from Australian fruit bats, highlighting the presence of multiple AMR genes such as bla TEM-1A, bla TEM-1B, bla CTX-M-27, bla NDM-5, and others, indicating anthropogenic origins of these resistant strains.
Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.
The study identifies plasmid-mediated cephalosporin resistance in Salmonella Typhi isolates from India, including bla SHV-12, bla TEM-1B, bla DHA-1, qnrB7, qnrB4, aac(6')Iaa, dfrA14, sul1, and sul2 genes. Chromosomal mutations in gyrA (S83F, D87N, S80I) and parC (S80I, E84K) contribute to fluoroquinolone resistance.
Biosolids as a Source of Antibiotic Resistance Plasmids for Commensal and Pathogenic Bacteria.
Six unique resistance plasmids were identified that can transfer to Salmonella typhimurium, Klebsiella aerogenes, and E. coli, carrying 3-6 antibiotic resistance genes conferring resistance to 2-4 antibiotic classes.
Multidrug-resistant bacteria as intestinal colonizers and evolution of intestinal colonization in healthy university students in Portugal.
The study identified various AMR genes in commensal E. coli isolates from healthy university students in Portugal, including bla TEM, tetA, tetB, sul1, sul2, sul3, parC, and gyrA, indicating the presence of multidrug-resistant bacteria in the intestinal microbiota.
Evaluation of Metagenomic-Enabled Antibiotic Resistance Surveillance at a Conventional Wastewater Treatment Plant.
The study evaluated the resistome in a conventional wastewater treatment plant, identifying several antibiotic resistance genes (ARGs) such as bla OXA-210, bla OXA-212, bla OXA-309, bla OXA-333, qnr S2, sul 1, sul 2, erm B, aac (6′)-Ib7, aac (6′)-Ib8, mph D, msr E, ade J, ade K, mex K, mtr A, sme R, oqx B, qac H, and others. These genes were found to confer resistance to various antibiotics, highlighting the importance of monitoring ARGs in wastewater treatment processes.
Genomic Insights into Drug Resistance and Virulence Platforms, CRISPR-Cas Systems and Phylogeny of Commensal E. coli from Wildlife.
The study identified various AMR genes in commensal E. coli strains from wildlife, including bla TEM-1, bla CTX-M-1, tet(A), tet(B), and several resistance gene cassettes in integrons. These genes were found to confer resistance to multiple antibiotics, highlighting the presence of AMR in wildlife E. coli populations.
WGS-Based Analysis of Carbapenem-Resistant Acinetobacter baumannii in Vietnam and Molecular Characterization of Antimicrobial Determinants and MLST in Southeast Asia.
The study identified several AMR genes in carbapenem-resistant Acinetobacter baumannii strains from Vietnam, including bla OXA-51-like, bla OXA-23, bla TEM-1, and others, highlighting the widespread resistance to beta-lactams, aminoglycosides, and other antibiotics.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Genomic analysis and phylogenetic position of the complex IncC plasmid found in the Spanish monophasic clone of Salmonella enterica serovar Typhimurium.
The study identifies various AMR genes in the IncC plasmid pUO-STmRV1, including blaTEM-1, cmlA1, aac(3)-IV, aadA1, aadA2, sul1, sul2, sul3, tet(A), dfrA12, arsR2, arsH, merRTPCADE, and silESRCBAP, which confer resistance to antibiotics and heavy metals.
Reversing Antibiotic Resistance Caused by Mobile Resistance Genes of High Fitness Cost.
The study shows that the mcr-1 gene, responsible for colistin resistance, can be deleted from the MDR plasmid pMCR_W5-6, leading to the restoration of colistin susceptibility in E. coli.
Subtypes, resistance and virulence platforms in extended-drug resistant Acinetobacter baumannii Romanian isolates.
The study identifies several AMR genes including bla OXA-23, bla OXA-24, bla OXA-51, and various aminoglycoside, sulfonamide, tetracycline, and macrolide resistance genes in XDR A. baumannii isolates from Romania.
First Detection of Human ST131-CTX-M-15-O25-B2 Clone and High-Risk Clonal Lineages of ESBL/pAmpC-Producing E. coli Isolates from Diarrheic Poultry in Tunisia.
The study identified the presence of the human pandemic ST131-CTX-M-15-O25-B2 clone and high-risk clonal lineages of ESBL/pAmpC-producing E. coli isolates from diarrheic poultry in Tunisia, highlighting the emergence of multidrug-resistant clones with various virulence determinants.
Antibiotic Resistant and Biofilm-Associated Escherichia coli Isolates from Diarrheic and Healthy Dogs.
The study identified several AMR genes in E. coli isolates from healthy and diarrheic dogs, including blaTEM-1, qnrB, qnrS, aac(6')-Ib-cr, tetA, tetB, dfrA, sul1, sul2, int1, and tn3. These genes confer resistance to various antibiotics such as ampicillin, ciprofloxacin, tetracycline, trimethoprim, and sulfonamide.
Transcriptomic Analysis of Drug-Resistance Acinetobacter baumannii under the Stress Condition Caused by Litsea cubeba L. Essential Oil via RNA Sequencing.
The study identifies several AMR genes in A. baumannii 17, including armA, sul2, tetB, and aac6'-1b, which confer resistance to beta-lactam, sulfonamide, tetracycline, and aminoglycoside antibiotics, respectively.
Molecular Characterization and Survive Abilities of Salmonella Heidelberg Strains of Poultry Origin in Brazil.
The study identified the presence of bla CTX-M and bla CMY-2 genes in Salmonella Heidelberg strains, which confer resistance to various beta-lactam antibiotics. These genes were detected in 80% of the strains, highlighting the prevalence of multidrug resistance in poultry-origin Salmonella Heidelberg.
WGS based analysis of acquired antimicrobial resistance in human and non-human Acinetobacter baumannii isolates from a German perspective.
The study identified multiple acquired antimicrobial resistance (AMR) genes in 189 German Acinetobacter baumannii strains, including blaADC.25, blaOXA-23, blaOXA-66, ant(3")-IIa, sul2, tet.B, mph.E, msr.E, and blaTEM, which confer resistance to various antibiotics such as aminoglycosides, cephalosporins, carbapenems, sulfonamides, tetracyclines, and macrolides.
Foodborne Pathogenic Vibrios: Antimicrobial Resistance.
The paper discusses the presence of various antibiotic resistance genes in Vibrio species, including strB, sul2, tetA, blaTEM, qnrA, ermB, floR, aac(3)-IIa, blaNDM-1, blaCMY, blaP1, catB3, and others, which confer resistance to antibiotics such as streptomycin, sulfamethoxazole, tetracycline, ampicillin, fluoroquinolones, erythromycin, florfenicol, gentamicin, carbapenems, chloramphenicol, and trimethoprim.
Prevalence and mechanisms of antibiotic resistance in Escherichia coli isolated from mastitic dairy cattle in Canada.
The study identified several AMR genes in E. coli isolates from bovine mastitis, including beta-lactamases (blaTEM-1, blaCARB-3, blaCMY-59), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aadA2), and multidrug efflux pump genes (acrA, acrB, acrD, tolC, baeR, emrA, emrB).
The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries.
The study identified multiple AMR genes and mutations in invasive non-typhoidal Salmonella isolates from sub-Saharan Africa, highlighting the prevalence of multidrug resistance.
Genomic Epidemiology of Multidrug-Resistant Nontyphoidal Salmonella in Young Children Hospitalized for Gastroenteritis.
Emergence and Clonal Spread of CTX-M-65-Producing Escherichia coli From Retail Meat in Portugal.
The study identifies the blaCTX-M-65 gene in four multidrug-resistant Escherichia coli isolates from retail meat in Portugal, highlighting its chromosomal location and association with various resistance mechanisms.
Honeybee Exposure to Veterinary Drugs: How Is the Gut Microbiota Affected?
The study identified tetracycline resistance genes tetW and tetY, and sulfonamide resistance genes sul1 and sul2 in the honeybee gut microbiota, which increased in abundance following antibiotic treatment.
Acquisition and loss of CTX-M plasmids in Shigella species associated with MSM transmission in the UK.
The study identifies the presence of bla CTX-M-27, erm(B), mph(A), aph(3')-Ib, aph(6)-Id, sul2, and tet(A) in Shigella isolates associated with MSM transmission in the UK, highlighting the role of plasmids in the spread of antimicrobial resistance.
Antibiotic Resistance and Virulence Profiles of Escherichia coli Strains Isolated from Wild Birds in Poland.
The study identified several AMR genes in E. coli strains isolated from wild birds in Poland, including blaTEM, aphA1, sul2, and tetA, which confer resistance to ampicillin, kanamycin, trimethoprim/sulfamethoxazole, and tetracycline, respectively.
Metagenomic analysis of MWWTP effluent treated via solar photo-Fenton at neutral pH: Effects upon microbial community, priority pathogens, and antibiotic resistance genes.
Solar photo-Fenton treatment effectively removed a wide range of antibiotic resistance genes (ARGs) including those conferring resistance to sulfonamides, macrolides, tetracyclines, and beta-lactams. The study identified several ARGs such as sul1, sul2, tet(X), erm(F), mph(A), mph(E), msr(E), aadA, aph(3"), aph(6), strA, and blaBKC.
Climatological and Epidemiological Conditions Are Important Factors Related to the Abundance of bla(KPC) and Other Antibiotic Resistance Genes (ARGs) in Wastewater Treatment Plants and Their Effluents, in an Endemic Country.
The study identified the prevalence of antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs) in Colombia, highlighting the significant presence of bla KPC, sul 1, sul 2, erm B, and others. It also found that environmental factors such as dissolved oxygen and precipitation correlate with the abundance of these genes.
Climatological and Epidemiological Conditions Are Important Factors Related to the Abundance of bla(KPC) and Other Antibiotic Resistance Genes (ARGs) in Wastewater Treatment Plants and Their Effluents, in an Endemic Country.
The study identified the prevalence of antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs) in Colombia, highlighting the significant presence of bla KPC, sul 1, sul 2, erm B, and others. It also found that environmental factors such as dissolved oxygen and precipitation correlate with the abundance of these genes.
Genomic Characterization of Multidrug-Resistant Salmonella Serovars Derby and Rissen From the Pig Value Chain in Vietnam.
The study identified multiple antimicrobial resistance genes in Salmonella serovars Derby and Rissen from Vietnam, highlighting the presence of multidrug-resistant strains along the pig value chain.
Discerning the Antimicrobial Resistance, Virulence, and Phylogenetic Relatedness of Salmonella Isolates Across the Human, Poultry, and Food Materials Sources in Malaysia.
The study identified several AMR genes in Salmonella Enteritidis isolates from Malaysia, including aac(6')-ly, blaCMY-2, blaTEM-1, blaTEM-33, blaTEM-4, dfrA14, dfrA15, floR, qnrS1, qnrD1, sul1, sul2, strA, strB, tetA, and tetC. These genes conferred resistance to various antibiotics such as gentamicin, ampicillin, chloramphenicol, ciprofloxacin, sulfamethazine/trimethoprim, and tetracycline.
Antimicrobial resistance and genomic characterization of Salmonella Dublin isolates in cattle from the United States.
The study characterized multidrug-resistant Salmonella Dublin isolates from cattle in the United States, identifying key AMR genes such as sul2, tetA, aph(6)-Id, aph(3''-Ib, floR, and blaCMY-2, along with quinolone resistance mutations in gyrA.
Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant K. pneumoniae strain KPE16, including bla NDM-1, bla CTX-M-15, and various aminoglycoside, sulfonamide, and tetracycline resistance genes. Additionally, chromosomal mutations in ompK36, ompK37, and acrR contribute to resistance.
Antimicrobial Resistance Patterns and Risk Factors Associated with Salmonella spp. Isolates from Poultry Farms in the East Coast of Peninsular Malaysia: A Cross-Sectional Study.
The study identified multiple antimicrobial resistance genes in Salmonella spp. isolates from poultry farms in Malaysia, including blaTEM, tet(A), tet(B), catA1, cat2, floR, sul1, and sul2, which confer resistance to beta-lactams, tetracyclines, chloramphenicol, and sulfonamides.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance Profiles in Non-typhoidal Salmonella enterica Strains Isolated From Cambodian Informal Markets.
The study identified 17 unique AMR genes in 53% of the 81 S. enterica isolates, including genes encoding resistance to tetracycline, beta-lactam, sulfonamide, quinolone, aminoglycoside, phenicol, and trimethoprim.
IS1294 Reorganizes Plasmids in a Multidrug-Resistant Escherichia coli Strain.
The study identifies and characterizes various AMR genes, including blaCTX-M-55, rmtB, oqxAB, blaTEM-1b, floR, tet(A), strA, strB, sul1, sul2, aac(3)-IId, aadA2, dfrA12, and aph(3′)-IIa, in a multidrug-resistant E. coli strain. These genes contribute to resistance against multiple antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, tetracyclines, sulfonamides, and trimethoprim.
Analysis of antibiotic-induced drug resistance of Salmonella enteritidis and its biofilm formation mechanism.
The study identified several antibiotic resistance genes in Salmonella enteritidis, including sul2, sul3, blaTEM-1-like, tet(A), and tet(G). These genes contribute to resistance against sulfamethoxazole, ampicillin, cefoxitin, cefotaxime, cefoperazone, ceftriaxone, cefepime, and tetracycline.
Molecular Epidemiological Analysis of ST11-K64 Extensively Drug-Resistant Klebsiella pneumoniae Infections Outbreak in Intensive Care and Neurosurgery Units Based on Whole-Genome Sequencing.
The study identified multiple AMR genes in ST11-K64 XDRKp strains, including beta-lactamases, aminoglycoside resistance genes, and efflux pumps, contributing to extensive drug resistance.
International High-Risk Clones Among Extended-Spectrum β-Lactamase-Producing Escherichia coli in Dhaka, Bangladesh.
The study identified several AMR genes and mutations in ESBL-producing E. coli isolates from Dhaka, Bangladesh, including bla CTX-M-15, bla NDM-5, mcr-1, and various aminoglycoside resistance genes. Mutations in gyrA and parC were also associated with fluoroquinolone resistance.
Sequence Analyses and Phenotypic Characterization Revealed Multidrug Resistant Gene Insertions in the Genomic Region Encompassing Phase 2 Flagellin Encoding fljAB Genes in Monophasic Variant Salmonella enterica Serovar 4,5,12:i:- Isolates From Various Sources in Thailand.
The study identified multiple multidrug resistance genes, including blaTEM-1B, strA, strB, sul2, and tetB, in Salmonella enterica serovar 4,5,12:i:- isolates from Thailand, which contribute to resistance against ampicillin, streptomycin, sulfonamides, and tetracycline.
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms.
The study identified several ESBL genes, colistin resistance genes, and other AMR genes in ESBL-producing E. coli from pigs and pig farm workers in Vietnam. Key findings include the prevalence of bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27, along with mcr-1 and mcr-3 for colistin resistance, and various other resistance genes for aminoglycosides, quinolones, tetracyclines, chloramphenicol, macrolides, and sulfonamides.
Identification of Three Novel PmGRI1 Genomic Resistance Islands and One Multidrug Resistant Hybrid Structure of Tn7-like Transposon and PmGRI1 in Proteus mirabilis.
The study identifies three novel variants of PmGRI1 and a hybrid structure combining Tn7-like transposon and PmGRI1 in Proteus mirabilis, highlighting their role in carrying multiple antibiotic resistance genes.
Investigation of the Genes Involved in the Outbreaks of Escherichia coli and Salmonella spp. in the United States.
The study identified several antimicrobial resistance genes in E. coli and Salmonella spp., including aadA1, aph(3"-Ib, aph(6)-Id, blaTEM-1, sul2, tet(A), and tet(B) in E. coli, and arsA, arsB, arsC, iroB, and iroC in Salmonella spp. Additionally, virulence genes such as epeA, stxA2d, stxB2c, subA, and subB were found to be unique to outbreak E. coli.
Transmission Dynamics of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 Strains Carrying Capsular Loci KL64 and rmpA/rmpA2 Genes.
The study identified multiple AMR genes and mutations in ST11-KL64 CRKP isolates, including bla KPC-2, rmtB, catA2, fosA, qnrS1, sul2, tet(A), aadA2, dfrA14, bla CTX-M-65, bla SHV-12, bla TEM-1B, iucABCD, iutA, rmpA2, and mutations in GyrA (S83I, D87G) and ParC (S80I).
Antibiotic resistance genes in layer farms and their correlation with environmental samples.
The study identified and quantified 13 antibiotic resistance genes (ARGs) in layer manure, layer manure fertilizer, and soil samples from Guangdong Province, highlighting the high prevalence and abundance of these genes, particularly ermB, tetA, and sul2, and their potential environmental impact.
Multidrug Resistance Dynamics in Salmonella in Food Animals in the United States: An Analysis of Genomes from Public Databases.
The study analyzed 22,102 Salmonella genomes from public databases to track antimicrobial resistance (AMR) trends in food animals in the United States. It found that the prevalence of multidrug resistance (MDR) decreased in bovines and swine but increased in poultry. Key AMR genes identified include bla CMY-2, bla CTX-M-65, floR, tetA, sul2, aadA2, aac(3)-VIa, qnrB19, qnrB2, bla SHV-12, bla TEM-1, bla CARB-2, aph(3")-Ib, aph(6)-Id, aph(3')-Ia, ant(3")-Ia, aph(4)-Ia, and aac(3)-IVa. A significant mutation, gyrA D87Y, was associated with quinolone resistance in poultry.
Phylogenetic and antimicrobial drug resistance analysis of Vibrio cholerae O1 isolates from Ghana.
The study identified multiple antimicrobial resistance genes in Vibrio cholerae O1 isolates from Ghana, including strA, strB, catB5, floR, sul2, and dfrA1, which confer resistance to streptomycin, chloramphenicol, florfenicol, sulfonamides, and trimethoprim/sulfamethoxazole. Additionally, mutations in gyrA (S83I) and parC (S85L) were found to contribute to fluoroquinolone resistance.
Monitoring the Microevolution of Salmonella enterica in Healthy Dairy Cattle Populations at the Individual Farm Level Using Whole-Genome Sequencing.
The study identified several AMR genes, including bla CMY-2, floR, sul2, and tetA, in Salmonella enterica isolates from dairy cattle. These genes confer resistance to various antibiotics such as cephalosporins, florfenicol, sulfamethoxazole-trimethoprim, and tetracycline.
Whole-Genomic Analysis of NDM-5-Producing Enterobacteriaceae Recovered from an Urban River in China.
The study identified multiple antimicrobial resistance genes, including bla NDM-5, bla OXA-10, and bla TEM-1B, in NDM-5-producing Enterobacteriaceae isolates from an urban river in China. These genes conferred resistance to various antibiotics such as carbapenems, cephalosporins, quinolones, and aminoglycosides.
Deciphering Multidrug-Resistant Acinetobacter baumannii from a Pediatric Cancer Hospital in Egypt.
The study identified various AMR genes and mutations in multidrug-resistant Acinetobacter baumannii isolates from a pediatric cancer hospital in Egypt, highlighting the presence of bla NDM, bla OXA-23-like, bla OXA-51-like, and other resistance genes, along with mutations in pmrA and lptF contributing to colistin resistance.
Invasive atypical non-typhoidal Salmonella serovars in The Gambia.
The study identified several antimicrobial resistance genes in invasive Salmonella serovars in The Gambia, including blaTEM-1B, aph(3'')-Ib, aph(6)-Id, catA1, dfrA7, sul1, sul2, tet(B), and fosA7. These genes conferred resistance to various antibiotics such as ampicillin, penicillin, gentamicin, kanamycin, tobramycin, chloramphenicol, trimethoprim, sulfamethoxazole, tetracycline, and fluoroquinolones.
Antimicrobial Susceptibility and Detection of Virulence-Associated Genes in Escherichia coli Strains Isolated from Commercial Broilers.
The study identified several AMR genes in E. coli strains from commercial broilers, including bla CTX-M-1 and bla CTX-M-2 for cephalosporin resistance, qnrA, qnrB, qnrS for fluoroquinolone resistance, aac(6')-Ib-cr for fluoroquinolone and aminoglycoside resistance, tetA and tetB for tetracycline resistance, sul1 and sul2 for sulfonamide resistance, aadA for aminoglycoside resistance, dfrA and dfrB for trimethoprim resistance, and mcr1 and mcr2 for polymyxin resistance.
Impact of Antibiotic Therapies on Resistance Genes Dynamic and Composition of the Animal Gut Microbiota.
The study examined the impact of antibiotic therapies on the dynamics and composition of resistance genes in the animal gut microbiota, identifying several AMR genes such as blaTEM, tetA, strA, strB, intI1, tetM, mel, floR, mcr-2, oqx B, tetC, tetG, tetO, tetW, tetX, ermB, ermF, sul1, sul2, and others, which were experimentally validated in Escherichia coli.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Phage Cocktail Development against Aeromonas salmonicida subsp. salmonicida Strains Is Compromised by a Prophage.
The study identifies antibiotic resistance genes such as sul1, sul2, floR, tetA, and cat in Aeromonas salmonicida subsp. salmonicida strains, highlighting their role in resistance to sulfonamides, chloramphenicol, and tetracycline. It also shows that the presence of Prophage 3 reduces the effectiveness of phage cocktails against these strains.
Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Strains Isolated at the German Military Field Laboratory in Mazar-e Sharif, Afghanistan.
The study identified bla OXA-23 as the primary cause of carbapenem resistance in Acinetobacter baumannii isolates from Afghanistan, along with various other resistance genes for sulfonamides, macrolides, tetracyclines, and aminoglycosides.
First report from Bangladesh on genetic diversity of multidrug-resistant Pasteurella multocida type B:2 in fowl cholera.
The study identified multidrug-resistant Pasteurella multocida type B:2 strains in fowl cholera cases in Bangladesh, highlighting the presence of various virulence factors and antimicrobial resistance genes.
Comparison of antimicrobial resistance and molecular characterization of Escherichia coli isolates from layer breeder farms in Korea.
The study identified several AMR genes in E. coli isolates from layer breeder farms in Korea, including bla TEM-1, tetA, tetB, qnrB, qnrS, sul1, sul2, aac(3)-II, and aac(6')-Ib. These genes conferred resistance to various antibiotics such as beta-lactams, tetracyclines, quinolones, sulfonamides, and aminoglycosides.
Genome Sequencing Identifies Previously Unrecognized Klebsiella pneumoniae Outbreaks in Neonatal Intensive Care Units in the Philippines.
The study identified several AMR genes, including bla CTX-M-15, bla NDM-1, rmtC, aac(6')-Ib, aac(3)-II, aph(3′′)-Ib, oqxA, oqxB, qnrB1, qnrS1, sul1, sul2, and dfrA, which were associated with resistance to various antibiotics in Klebsiella pneumoniae isolates from the Philippines.
Mouse pneumonia model by Acinetobacter baumannii multidrug resistant strains: Comparison between intranasal inoculation, intratracheal instillation and oropharyngeal aspiration techniques.
The study identified various AMR genes in two multidrug-resistant Acinetobacter baumannii strains, ACC001 and ACC002, including aminoglycoside resistance genes, tetracycline resistance genes, beta-lactamases, and sulfonamide resistance genes. These genes contribute to resistance against multiple antibiotics such as gentamicin, tobramycin, tetracycline, penicillins, cephalosporins, and sulfonamides.
Genomic Characterization of Extensively Drug-Resistant NDM-Producing Acinetobacter baumannii Clinical Isolates With the Emergence of Novel bla (ADC-257).
The study identified several AMR genes, including novel bla ADC-257, and mutations in gyrA and parC associated with fluoroquinolone resistance in extensively drug-resistant NDM-producing Acinetobacter baumannii isolates.
Genomic diversity of antimicrobial resistance in non-typhoidal Salmonella in Victoria, Australia.
The study identified various AMR genes and mutations in non-typhoidal Salmonella, including bla TEM-1, bla TEM-135, strAB, sul1, sul2, tet(A), tet(B), floR, bla CMY-2, bla CTX-M-55, and bla CTX-M-65, along with mutations in gyrA and parC contributing to ciprofloxacin resistance.
Letter to the Editor: Importation of the First Bovine ST361 New Delhi Metallo-5 Positive Escherichia coli in Greece.
The study reports the first bovine ST361 NDM-5 positive Escherichia coli in Greece, highlighting the importation of multidrug-resistant strains and the need for continued surveillance.
The Relationship between Antibiotic Susceptibility and pH in the Case of Uropathogenic Bacteria.
The study identified several AMR genes including aac(69)-Ib-cr, oqxAB, sul2, tem, shv, ctx-m, and oxa in uropathogenic bacteria. These genes were associated with resistance to various antibiotics such as gentamicin, ciprofloxacin, norfloxacin, and trimethoprim/sulfamethoxazole.
Pan-Resistome Characterization of Uropathogenic Escherichia coli and Klebsiella pneumoniae Strains Circulating in Uganda and Kenya, Isolated from 2017-2018.
The study identified various AMR genes in uropathogenic E. coli and K. pneumoniae strains from Uganda and Kenya, highlighting the prevalence of multidrug-resistant (MDR) and extended-spectrum beta-lactamase (ESBL)-producing strains.
Whole-Genome Sequencing-Based Antimicrobial Resistance Characterization and Phylogenomic Investigation of 19 Multidrug-Resistant and Extended-Spectrum Beta-Lactamase-Positive Escherichia coli Strains Collected From Hospital Patients in Benin in 2019.
The study identified multiple AMR genes and mutations in 19 ESBL-positive E. coli isolates from Benin, including bla CTX-M-15, bla OXA-1, bla TEM-1, aac(6')-Ib-cr, qnrS1, tet(B), sul2, and dfrA17, as well as mutations in parC and gyrA associated with fluoroquinolone resistance.
Genomic characteristics and comparative genomics of Salmonella enterica subsp. enterica serovar Schwarzengrund strain S16 isolated from chicken feces.
Antimicrobial Resistance of Escherichia coli From Aquaculture Farms and Their Environment in Zhanjiang, China.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia coli isolates from aquaculture farms in Zhanjiang, China, including blaTEM, blaCIT, floR, OptrA, cmlA, aphA1, Sul2, oqxA, qnrS, and mcr1. These genes conferred resistance to various antibiotics such as beta-lactams, chloramphenicol, florfenicol, aminoglycosides, sulfonamides, quinolones, and colistin.
Variants of Tn6924, a Novel Tn7 Family Transposon Carrying the bla(NDM) Metallo-β-Lactamase and 14 Copies of the aphA6 Amikacin Resistance Genes Found in Acinetobacter baumannii.
The study identified Tn6924, a novel Tn7 family transposon carrying bla(NDM) and 14 copies of aphA6 in Acinetobacter baumannii, contributing to multidrug resistance.
Genomic evolution of the globally disseminated multidrug-resistant Klebsiella pneumoniae clonal group 147.
The study identifies multiple AMR genes and mutations in the pandrug-resistant K. pneumoniae strain DJ, including carbapenemases (bla NDM-5, bla OXA-181, bla CTX-M-15), aminoglycoside resistance genes (rmtB, rmtF, aac(6')-Ib, aadA2, strAB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase (dfrA12), polymyxin resistance gene (mgrB), tetracycline resistance gene (ramR), chloramphenicol resistance genes (catA2, catB), fosfomycin resistance gene (fosA), and macrolide resistance genes (mphA, ermB). Mutations in gyrA, parC, ompK35, ompK36, and ramR contribute to resistance to fluoroquinolones, polymyxins, tetracyclines, and other antibiotics.
The Evolutionary Trend and Genomic Features of an Emerging Lineage of Elizabethkingia anophelis Strains in Taiwan.
The Genomic Characterization of KPC-Producing Klebsiella pneumoniae from the ICU of a Teaching Hospital in Shanghai, China.
The study identified the carbapenemase gene blaKPC-2 and blaKPC-24, along with fosfomycin resistance gene fosA6, and various extended-spectrum beta-lactamase genes such as blaCTX-M-15, blaCTX-M-65, and blaCTX-M-27 in KPC-producing Klebsiella pneumoniae strains. Additionally, genes associated with fluoroquinolone, macrolide, aminoglycoside, and sulfonamide resistance were also characterized.
One Health Genomic Study of Human and Animal Klebsiella pneumoniae Isolated at Diagnostic Laboratories on a Small Caribbean Island.
The study identified various AMR genes in Klebsiella pneumoniae isolates from humans and animals on St. Kitts, including bla CTX-M-15, bla TEM-1b, bla TEM-206, bla OXA-1, and others, highlighting host-specific differences in resistance profiles.
NDM-1 Introduction in Portugal through a ST11 KL105 Klebsiella pneumoniae Widespread in Europe.
The study characterizes the first recognized outbreak of NDM-1-producing K. pneumoniae in Portugal, highlighting the introduction of a new ST11 KL105 strain carrying blaNDM-1 in a unique genetic context. Several antibiotic resistance genes, including blaNDM-1, blaCTX-M-15, and others, were identified, along with chromosomal mutations conferring reduced susceptibility to fluoroquinolones and fosfomycin.
Antimicrobial Susceptibility Profiles among Pseudomonas aeruginosa Isolated from Professional SCUBA Divers with Otitis Externa, Swimming Pools and the Ocean at a Diving Operation in South Africa.
The study identified multiple beta-lactamase genes (blaAmpC, blaTEM, blaOxa-4, CTX-M1, blaSHV), sulfonamide resistance genes (sul1, sul2), and integron genes (IntI1, IntI2) in P. aeruginosa isolates from SCUBA divers, swimming pools, and the ocean in Sodwana Bay, South Africa, indicating a high level of multidrug resistance.
Plethora of Resistance Genes in Carbapenem-Resistant Gram-Negative Bacteria in Greece: No End to a Continuous Genetic Evolution.
The study identified a variety of resistance genes in carbapenem-resistant Gram-negative bacteria, including bla KPC, bla NDM, bla VIM, and others, highlighting the complex genetic diversity of these pathogens.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
Isolation of Elizabethkingia anophelis From COVID-19 Swab Kits.
The study identified multiple beta-lactamase genes (bla B, bla CME, bla GOB, and bla OXA), as well as the anti-macrolide gene ere(D), the sulfa-resistant gene sul2, and the anti-tetracycline gene tet(X) in Elizabethkingia anophelis isolates, indicating multidrug resistance.
Colistin Resistance in Monophasic Isolates of Salmonella enterica ST34 Collected From Meat-Derived Products in Spain, With or Without CMY-2 Co-production.
The study identifies the mcr-1.1 gene on IncX4 and IncHI2 plasmids as the primary determinant of colistin resistance in Salmonella enterica ST34 isolates from meat products in Spain. Additionally, the bla CMY-2 gene on an IncI1-I(α) plasmid was found to confer resistance to cefotaxime and cefoxitin.
Mobile Genetic Elements Drive Antimicrobial Resistance Gene Spread in Pasteurellaceae Species.
The study identifies 33 distinct AMR genes associated with mobile genetic elements (MGEs) in Pasteurellaceae species, highlighting the role of MGEs in the spread of antimicrobial resistance.
Antibiotic resistance genes in gut of breast-fed neonates born by caesarean section originate from breast milk and hospital ward air.
The study identifies multiple antibiotic resistance genes (ARGs) in the gut of breast-fed neonates born via cesarean section, primarily originating from breast milk and hospital ward air. Key ARGs include mecA, blaTEM, ampC, tetM, ermB, sul2, and aac(6)-Ib, which were detected in S. epidermidis isolates from neonatal faeces, colostrum, and ward air.
Decreasing the abundance of tetracycline-resistant Escherichia coli in pig feces during nursery using flavophospholipol as a pig feed additive.
Flavophospholipol (FPL) effectively reduced the abundance of tetracycline-resistant Escherichia coli in pig feces by inhibiting conjugational transfer and growth of resistant plasmids carrying tetA, tetB, blaTEM-1B, mdfA, aph(3')-I, sul2, aadA1, and dfrA1.
Genome Informatics and Machine Learning-Based Identification of Antimicrobial Resistance-Encoding Features and Virulence Attributes in Escherichia coli Genomes Representing Globally Prevalent Lineages, Including High-Risk Clonal Complexes.
The study identified 247 AMR genes across 19 STs of E. coli, including beta-lactamases (ampC, blaTEM-4), quinolone resistance (qnrS1), sulfonamide resistance (sul1, sul2), and efflux pumps (emrE, floR).
Genomic and phenotypic analyses of diverse non-clinical Acinetobacter baumannii strains reveals strain-specific virulence and resistance capacity.
The study analyzed diverse non-clinical Acinetobacter baumannii strains and found that they exhibit strain-specific virulence and resistance capacities, with some strains showing similarities to global clone lineages associated with nosocomial infections. However, these environmental strains were generally more sensitive to antibiotics compared to clinical strains.
A Genomic and Bioinformatics View of the Classification and Evolution of Morganella Species and Their Chromosomal Accessory Genetic Elements Harboring Antimicrobial Resistance Genes.
The study identified 88 acquired antimicrobial resistance genes (ARGs) in 166 Morganella isolates, with a focus on tetracycline, aminoglycoside, sulfonamide, trimethoprim, and beta-lactam resistance genes. Key ARGs included blaKPC-2, blaNDM-1, aacA4, aadA5, dfrA17, catB3, arr-3, blaOXA-1, aacA4cr, mph(A), rmtB, sul2, floR, qnrS1, tetA, and ermB.
Genomic Analysis of ESBL-Producing E. coli in Wildlife from North-Eastern Germany.
The study identified ESBL-producing E. coli in wild boar and wild ruminants with a low prevalence. The most prevalent ESBL type was CTX-M-1. The study also found resistance genes for aminoglycosides, phenicol, sulfonamides, and tetracyclines.
First Description of Ceftazidime/Avibactam Resistance in a ST13 KPC-70-Producing Klebsiella pneumoniae Strain from Portugal.
The study reports the first description of ceftazidime/avibactam resistance in a ST13 KPC-70-producing Klebsiella pneumoniae strain from Portugal. The strain was found to harbor the blaKPC-70 gene, a variant of blaKPC-3 with two amino acid substitutions (D179Y and T263A), which conferred resistance to several β-lactam antibiotics.
Comparison of Reference-Based Assembly and De Novo Assembly for Bacterial Plasmid Reconstruction and AMR Gene Localization in Salmonella enterica Serovar Schwarzengrund Isolates.
The study identified various AMR genes in Salmonella enterica serovar Schwarzengrund isolates, including aadA2, AAC(3)-IV, AAC(6')-Iy, APH(4)-Ia, cmlA1, dfrA12, floR, sul1, sul2, sul3, TEM-1, and tet(A). These genes were located on both the chromosome and plasmids, highlighting the importance of plasmid-mediated AMR gene transmission.
Population genomics of the food-borne pathogen Vibrio fluvialis reveals lineage associated pathogenicity-related genetic elements.
The study identified 21 antimicrobial resistance genes in Vibrio fluvialis, with 19 of them predominantly present in VflPop2. The tetracycline resistance gene tet(35) was found in 95% of VflPop2 strains, highlighting its significance in the population. Additionally, the plasmid pBD146 was associated with resistance to trimethoprim-sulfamethoxazole, and the presence of dfr6 gene in pBD146 was linked to this resistance.
First identification of bla (NDM-5) producing Escherichia coli from neonates and a HIV infected adult in Tanzania.
The study identifies bla NDM-5 producing Escherichia coli in Tanzania, highlighting the presence of carbapenem resistance and other resistance genes on various plasmids.
Pan-Genome Analysis of Delftia tsuruhatensis Reveals Important Traits Concerning the Genetic Diversity, Pathogenicity, and Biotechnological Properties of the Species.
The study identifies multiple antimicrobial resistance genes in Delftia tsuruhatensis, including aminoglycoside, sulfonamide, trimethoprim, tetracycline, and phenicol resistance genes, indicating the potential for multidrug resistance in this species.
Antimicrobial Resistance and Virulence of Non-Typhoidal Salmonella from Retail Foods Marketed in Bangkok, Thailand.
The study identified several AMR genes in Salmonella Enteritidis isolates from retail food samples in Bangkok, including blaTEM-1, tetA, sul2, and dfrA7, which confer resistance to various antibiotics.
Genetic Diversity of Antimicrobial Resistance and Key Virulence Features in Two Extensively Drug-Resistant Acinetobacter baumannii Isolates.
The study identified various AMR genes in two extensively drug-resistant A. baumannii isolates, including aminoglycoside resistance genes, sulfonamide resistance genes, beta-lactamase genes, and efflux pump genes, highlighting the complexity of their resistance mechanisms.
Genetic Characterization of Antibiotic Resistant Enterobacteriaceae Isolates From Bovine Animals and the Environment in Nigeria.
The study characterizes antibiotic resistance genes in Enterobacteriaceae isolates from bovine animals and the environment in Nigeria, identifying several beta-lactamase, aminoglycoside modifying enzymes, qnr, sulfonamide, tetracycline, and trimethoprim resistance genes, highlighting the presence of multidrug-resistant strains.
A Metagenomic Approach for Characterizing Antibiotic Resistance Genes in Specific Bacterial Populations: Demonstration with Escherichia coli in Cattle Manure.
The study identified multiple antibiotic resistance genes in E. coli populations from cattle manure, including genes conferring resistance to tetracycline, aminoglycosides, chloramphenicol, sulfonamides, and glycopeptides. These genes were found to be associated with mobile genetic elements, highlighting the potential for horizontal gene transfer.
Frequently used therapeutic antimicrobials and their resistance patterns on Staphylococcus aureus and Escherichia coli in mastitis affected lactating cows.
The study identified several antimicrobial resistance genes in Staphylococcus aureus and Escherichia coli isolated from mastitis-affected cows, including mecA, tetK, tetL, tetA, tetB, sul1, and sul2. These genes confer resistance to various antibiotics such as tetracycline, sulfamethoxazole-trimethoprim, and methicillin.
Virulome and genome analyses identify associations between antimicrobial resistance genes and virulence factors in highly drug-resistant Escherichia coli isolated from veal calves.
The study identifies multiple antimicrobial resistance genes (ARGs) in highly drug-resistant Escherichia coli isolates from veal calves, including blaCMY-2, blaCTX-M-15, mph(A), erm(B), aac(6')-Ib-cr, qnrS1, aadA5, aadA1, aph(3')-Ic, aph(3')-Ia, aph(3')-Ib, aph(6')-Id, sul1, sul2, tet(A), and tet(B). Additionally, mutations in gyrA (S83L, D87N) and parC (A56T) were found to contribute to fluoroquinolone resistance.
Genomic diversity and antimicrobial resistance among non-typhoidal Salmonella associated with human disease in The Gambia.
The study identified various antimicrobial resistance (AMR) genes in non-typhoidal Salmonella isolates from The Gambia, including aac(6')-Iaa_1, aph_3_Ib, aph_6_Id, dfrA14, dfrA7, dfrA8, blaTEM-1B, catA1_1, fosA7_1, mph_A, sul1, sul2, tet_A, and tet_B. These genes confer resistance to aminoglycosides, trimethoprim, beta-lactams, chloramphenicol, fosfomycin, macrolides, sulfonamides, and tetracyclines. The study also found that multidrug resistance (MDR) was primarily associated with Salmonella serovar Enteritidis, especially in the eastern region.
Genomic Investigation Reveals a Community Typhoid Outbreak Caused by Contaminated Drinking Water in China, 2016.
The study identified a community typhoid fever outbreak in China linked to contaminated drinking water. One isolate, 1114, was found to carry the sul2 gene, which confers resistance to sulfonamides.
Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella isolates from Senegal, highlighting the prevalence of resistance to fluoroquinolones, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin. Key genes included aac(3)-Id, aadA7, blaTEM-1b, blaDHA-1, blaOXA-10, blaCMY-2, dfrA1, dfrA14, floR, fosA, qnrB19, qnrB7, sul2, tetA, tetB, aph(3')-Ib, aph(3")-Ib, and aph(6)-Id. Mutations in parC and gyrA were also associated with fluoroquinolone resistance.
Invited Review: Antimicrobial Use and Antimicrobial Resistance in Pathogens Associated with Diarrhea and Pneumonia in Dairy Calves.
The review identified several AMR genes in pathogens associated with calf diarrhea and pneumonia, including beta-lactamases (blaCMY, blaCTX-M, blaTEM), tetracycline resistance genes (tetA, tetB, tetM, tetO), aminoglycoside resistance genes (strA, strB, aadA), sulfonamide resistance genes (sul1, sul2), phenicol resistance genes (cat, floR), and macrolide/lincosamide resistance genes (cfr, ermB).
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
Genomic Profiling of Antibiotic-Resistant Escherichia coli Isolates from Surface Water of Agricultural Drainage in North-Western Mexico: Detection of the International High-Risk Lineages ST410 and ST617.
The study identified multidrug-resistant Escherichia coli isolates from surface water in north-western Mexico, including international high-risk lineages ST410 and ST617. These isolates carried various AMR genes such as blaTEM-1B, blaCTX-M-15, aadA1, aadA2, aadA5, aac(3)-IIa, aac(3)-IId, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, floR, cmlA1, lnu(F), mdf(A), sul2, sul3, tet(A), tet(B), dfrA12, and dfrA17. Additionally, mutations in gyrA (S83L, D87N), parC (S80I), and parE (S458A) were found to contribute to fluoroquinolone resistance.
Use of genomics to explore AMR persistence in an outdoor pig farm with low antimicrobial usage.
The study identified various AMR genes in E. coli isolates from a low antimicrobial usage pig farm, highlighting the persistence of multidrug-resistant strains despite minimal selective pressure.
Antimicrobial resistance determinants in silage.
The study identified 16 antimicrobial resistance genes (ARGs) in silage samples, highlighting their potential to spread through the food chain and contribute to antimicrobial resistance.
Prevalence and Diversity of Antibiotic Resistant Escherichia coli From Anthropogenic-Impacted Larut River.
The study identified several tetracycline and sulfonamide resistance genes, including tet(A), tet(L), tet(X), sul2, and sul3, in Escherichia coli isolates from the Larut River, highlighting the prevalence of antibiotic resistance in anthropogenically impacted aquatic environments.
Mechanism for Reducing the Horizontal Transfer Risk of the Airborne Antibiotic-Resistant Genes of Escherichia coli Species through Microwave or UV Irradiation.
The study identified that the sul1, sul2, and sul3 genes in E. coli CICC 10667 contribute to sulfanilamide resistance and are more resistant to microwave irradiation compared to other genes. The effectiveness of microwave irradiation in reducing the horizontal transfer risk of antibiotic-resistant genes was demonstrated.
Litter Commensal Bacteria Can Limit the Horizontal Gene Transfer of Antimicrobial Resistance to Salmonella in Chickens.
The study identifies several AMR genes, including blaTEM-1B, tetA, aadA1, mer operon, sul2, silABCFRS, pcoABCDRS, iroBCDEN, and intI1, which are associated with Salmonella enterica serovar Heidelberg isolates from both fresh and reused litter. These genes contribute to resistance against various antibiotics such as ampicillin, tetracycline, gentamicin, sulfonamide, silver, copper, and mercury.
Drinking water chlorination has minor effects on the intestinal flora and resistomes of Bangladeshi children.
The study identified several antibiotic resistance genes (ARGs) in the gut microbiome of Bangladeshi children, including bla CTX-M, mph(A), qnrS1, mdf(A), tet(A), sul2, aadA5, tet(X), erm(X), nimE, dfrA17, bla TEM, and ant(6’)-Ia. These genes were associated with resistance to various antibiotics such as third-generation cephalosporins, azithromycin, fluoroquinolones, tetracyclines, sulfonamides, streptomycin, spectinomycin, macrolides, lincosamides, streptogramin B, nitroimidazoles, trimethoprim, penicillins, and aminoglycosides.
Analysis of Antimicrobial Resistance in Non-typhoidal Salmonella Collected From Pork Retail Outlets and Slaughterhouses in Vietnam Using Whole Genome Sequencing.
The study identified several AMR genes in non-typhoidal Salmonella isolates from pork retail outlets and slaughterhouses in Vietnam, including blaTEM-1, blaTEM-150, blaLAP-2, blaCTX-M-55, dfrA12, dfrA14, floR, cmlA1, tetA, tetB, tetM, mcr-1, mcr-3, qnrS1, mphA, aadA1, aadA2, aac(6')-laa, aac(6')-ly, sul1, sul2, sul3, aph(3")-lb, and aph6-ld. These genes conferred resistance to various antibiotics such as ampicillin, penicillins, first-generation cephalosporins, quinolones, trimethoprim, chloramphenicol, tetracycline, colistin, macrolides, gentamicin, sulfonamides, and others.
Metagenomic Insights Into the Changes of Antibiotic Resistance and Pathogenicity Factor Pools Upon Thermophilic Composting of Human Excreta.
The study identified a decrease in the abundance of various antibiotic resistance genes (ARGs) during thermophilic composting of human excreta, including genes conferring resistance to aminoglycosides, macrolides, sulfonamides, and tetracyclines.
In vitro Synergistic Activities of Fosfomycin in Combination with Other Antimicrobial Agents Against Carbapenem-Resistant Escherichia coli Harboring bla (NDM-1) on the IncN2 Plasmid and a Study of the Genomic Characteristics of These Pathogens.
The study identified several AMR genes in bla NDM-1 -harboring CREC isolates, including bla NDM-1, aac(3)-IId, aph(3")-Ib, aph(6)-Id, aadA5, aadA16, aac(6')-Ib-cr, qnrB6, ARR-3, dfrA17, dfrA27, sul1, sul2, tet(A), mph(A), bla TEM-1C, bla TEM-57, bla CTX-M-14, bla CTX-M-15, and bla CMY-2. These genes conferred resistance to various antibiotics, including carbapenems, aminoglycosides, fluoroquinolones, rifampicin, trimethoprim, sulfonamides, tetracycline, and macrolides.
Antimicrobial Resistance in Escherichia coli from the Broiler Farm Environment, with Detection of SHV-12-Producing Isolates.
The study identifies SHV-12-producing Escherichia coli isolates in a broiler farm environment, highlighting the presence of various antimicrobial resistance genes such as bla SHV-12, cmlA, tet (A), aac(6′)-Ib-cr, and others. These genes confer resistance to multiple antibiotics, emphasizing the need for monitoring and controlling AMR in agricultural settings.
Antimicrobial Resistance and Transconjugants Characteristics of sul3 Positive Escherichia coli Isolated from Animals in Nanning, Guangxi Province.
The study identified sul3-positive E. coli strains with multiple antibiotic resistance genes, including sul3, sul2, tetA, floR, oqxA, and mcr-1, highlighting the potential for horizontal gene transfer and the need for long-term monitoring of antimicrobial resistance in Nanning.
Comparison of Two Distinct Subpopulations of Klebsiella pneumoniae ST16 Co-Occurring in a Single Patient.
The study identifies multiple AMR genes and mutations in Klebsiella pneumoniae ST16 isolates, including bla NDM-4, bla OXA-181, and a frameshift mutation in acrR, contributing to carbapenem and fluoroquinolone resistance.
Urban Wildlife Crisis: Australian Silver Gull Is a Bystander Host to Widespread Clinical Antibiotic Resistance.
The study identifies multiple antibiotic resistance genes, including bla_IMP-4, bla_SHV-12, sul1, sul2, mphA, and floR, in Escherichia coli isolates from Australian silver gulls, highlighting the role of wildlife in the spread of clinical antibiotic resistance.
Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017.
The study identified several AMR genes in K. pneumoniae isolates, including bla CTX-M-15, bla SHV-27, bla SHV-1, bla SHV-101, bla SHV-108, bla TEM-1B, qnrB66, aac(3)-IIa, dfrA14, strA, strB, sul2, and tet(A). These genes conferred resistance to various antibiotics such as beta-lactams, quinolones, aminoglycosides, sulfonamides, and tetracyclines.
Genetic Characterization of Four Groups of Chromosome-Borne Accessory Genetic Elements Carrying Drug Resistance Genes in Providencia.
This study characterizes four groups of chromosome-borne accessory genetic elements (AGEs) in Providencia, highlighting the diversity and complexity of multidrug resistance (MDR) regions within these elements. It identifies numerous drug resistance genes, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and others, contributing to the understanding of AMR mechanisms in Providencia.
Characterization of qnrB-carrying plasmids from ESBL- and non-ESBL-producing Escherichia coli.
The study characterized qnrB-carrying plasmids from ESBL- and non-ESBL-producing E. coli, identifying qnrB1, qnrB2, and qnrB19 as major quinolone resistance determinants. These plasmids were found to be self-transmissible and associated with various resistance genes.
Highly prevalent MDR, frequently carrying virulence genes and antimicrobial resistance genes in Salmonella enterica serovar 4,[5],12:i:- isolates from Guizhou Province, China.
The study identified multiple antimicrobial resistance genes, including bla TEM-1, strA-strB, sul2, tetB, and bla CTX-M, in Salmonella enterica serovar 4,[5],12:i:- isolates from Guizhou, China, highlighting the high prevalence of multidrug resistance.
Prevalence, Characteristics, and Clonal Distribution of Escherichia coli Carrying Mobilized Colistin Resistance Gene mcr-1.1 in Swine Farms and Their Differences According to Swine Production Stages.
The study identified the mobilized colistin resistance gene mcr-1.1 in Escherichia coli isolates from swine farms, highlighting its prevalence and association with multidrug resistance.
Submarine Outfalls of Treated Wastewater Effluents are Sources of Extensively- and Multidrug-Resistant KPC- and OXA-48-Producing Enterobacteriaceae in Coastal Marine Environment.
The study identified extensively drug-resistant (XDR) and multidrug-resistant (MDR) KPC- and OXA-48-producing Enterobacteriaceae in coastal marine environments, highlighting the presence of various AMR genes including bla KPC-2, bla OXA-48, and others.
Occurrence and Genomic Characterization of Clone ST1193 Clonotype 14-64 in Uncomplicated Urinary Tract Infections Caused by Escherichia coli in Spain.
The study identified the occurrence of fluoroquinolone-resistant ST1193 clone in uncomplicated urinary tract infections (uUTI) caused by Escherichia coli in Spain. Several AMR genes and mutations were characterized, including blaTEM-1B, aph(3')-Ib, aph(6)-Id, mdf(A), mph(A), sul2, dfrA14, dfrA17, sitABCD, and chromosomal mutations in gyrA (S83L, D87N), parC (S80I), and parE (L416F).
Outbreak of Imported Seventh Pandemic Vibrio cholerae O1 El Tor, Algeria, 2018.
The 2018 cholera outbreak in Algeria involved Vibrio cholerae O1 El Tor isolates with resistance to streptomycin, sulfamethoxazole, trimethoprim, and sulfamethoxazole/trimethoprim, decreased susceptibility to ciprofloxacin, and intermediate resistance to chloramphenicol and nitrofurantoin. Mutations in gyrA (S83I), parC (S85L), nfsA (R169C), nfsB (Q5Stop), and vprA (D89N) were identified as contributing to the resistance profiles.
Genomic epidemiology and temperature dependency of hypermucoviscous Klebsiella pneumoniae in Japan.
The study identifies multiple AMR genes and mutations in hypermucoviscous Klebsiella pneumoniae isolates from Japan, highlighting the presence of ESBLs, carbapenemases, and other resistance determinants. It also reveals temperature-dependent variations in the HMV phenotype and the genetic diversity of the isolates.
Genomic Analysis of Multidrug-Resistant Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Strain Lacking the Hypermucoviscous Regulators (rmpA/rmpA2).
The study identified multiple antimicrobial resistance genes in a multidrug-resistant hypervirulent Klebsiella pneumoniae strain, including beta-lactamases, sulfonamide resistance genes, fosfomycin resistance genes, aminoglycoside resistance genes, and tetracycline resistance genes.
KPC-3-, GES-5-, and VIM-1-Producing Enterobacterales Isolated from Urban Ponds.
The study identified bla KPC-3, bla GES-5, and bla VIM genes in various Enterobacterales isolates from urban ponds, highlighting their role in carbapenem resistance.
Antimicrobial Resistance in Acinetobacter spp. Isolated from Pet Reptiles
The study identified various AMR genes in Acinetobacter spp. isolated from pet reptiles, including tetracycline, sulfonamide, and aminoglycoside resistance genes, highlighting the presence of multidrug-resistant strains in these animals.
Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen.
The study identifies multiple AMR genes and mutations in Klebsiella pneumoniae isolates, including bla CTX-M-15, bla IMP-4, bla OXA-48, qnrB1, qnrS1, aac(6')-Ib-cr, rmtB, aac(6')-Ib4, aadA2, ant(2")-Ia, ermB, arr-2, dfrA14, sul2, and sul1, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, aminoglycosides, and sulfonamides.
Clinical and Genomic Investigation of an International Ceftriaxone- and Azithromycin-Resistant Shigella sonnei Cluster among Men Who Have Sex with Men, Montréal, Canada 2017-2019.
Evaluating the potential of third generation metagenomic sequencing for the detection of BRD pathogens and genetic determinants of antimicrobial resistance in chronically ill feedlot cattle.
The study identified various antimicrobial resistance genes (ARGs) in metagenomic sequencing data from chronically ill feedlot cattle, including genes conferring resistance to beta-lactams, aminoglycosides, macrolides, phenicols, tetracyclines, and trimethoprim. Notably, tetH was the most frequently detected resistance gene, and several ARGs were found to be associated with integrative and conjugative elements (ICEs).
RETRACTED: Isolation and molecular characterization of extended spectrum beta lactamase producing Escherichia coli from chicken meat in Pakistan.
The study identified several AMR genes including blaOXA-1, blaTEM-1, blaCTX-M15, QnrS, TetA, AAC, AAD, Sul1, and Sul2 in E. coli isolates from chicken meat in Pakistan. Mutations in blaOXA-1 (H81Q), blaTEM-1 (C108Y, T214A, K284E, P301S), QnrS (H95R), and Sul2 (E66A) were also detected.
Escherichia coli ST1193: Following in the Footsteps of E. coli ST131
The paper characterizes Escherichia coli ST1193 as an emerging multidrug-resistant clone with various AMR determinants, including beta-lactamases (bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-55, bla OXA-1, bla TEM-1, bla CMY-42, bla CMY-2), aminoglycoside-modifying enzymes (aac(3)-IIa, aac(3)-IId, aac(6′)-Ib-cr, aadA1, aadA2, aadA5, aph(3′′)-Ib, aph(6)-Id), and other resistance genes (mcr-1, mph(A), erm(B), dfrA8, dfrA12, dfrA17, sul1, sul2, tetA, tetB).
Epidemiological and genetic characteristics of clinical carbapenem-resistant Acinetobacter baumannii strains collected countrywide from hospital intensive care units (ICUs) in China.
The study identified multiple AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii (CRAB) strains, highlighting the prevalence of bla OXA-23 and bla OXA-66 as key determinants of carbapenem resistance, along with other resistance mechanisms such as mutations in efflux pump genes and modifications in lipopolysaccharide synthesis.
GR13-type plasmids in Acinetobacter potentiate the accumulation and horizontal transfer of diverse accessory genes.
The study identifies multiple antibiotic resistance genes, including bla OXA-58, bla NDM-1, ble MBL, sul2, aacC2d, msr(E)-mph(E), and tet(B), in GR13-type plasmids from Acinetobacter isolates, highlighting their role in multidrug resistance and horizontal gene transfer.
KPC-3-Producing Klebsiella pneumoniae Sequence Type 392 from a Dog's Clinical Isolate in Portugal.
The study characterizes a KPC-3-producing Klebsiella pneumoniae ST392 isolate from a dog in Portugal, highlighting the presence of multiple AMR genes including blaKPC-3, aac(6')-lb-cr, tet(A), sul2, qnrB1, and OqxB/A, indicating multidrug resistance.
Cross-Sectional Survey of Antibiotic Resistance in Extended Spectrum β-Lactamase-Producing Enterobacteriaceae Isolated from Pigs in Greece.
The study identified a high prevalence of ESBL-producing Enterobacteriaceae in Greek pigs, with a focus on resistance mechanisms involving bla CTX-M1/15, bla TEM, and bla SHV genes, as well as resistance to fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and colistin.
Occurrence of bla(NDM-1)-Positive Providencia spp. in a Pig Farm of China.
Four bla NDM-1-positive Providencia strains were identified in a pig farm in China, showing multidrug resistance and carrying additional resistance genes such as bla OXA-10, bla TEM-116, and others.
Characterization of β-Lactamases and Multidrug Resistance Mechanisms in Enterobacterales from Hospital Effluents and Wastewater Treatment Plant.
The study identified several β-lactamase genes, including bla CTX-M-27, bla TEM-1, bla CTX-M-15, bla CTX-M-30, and bla SHV-12, along with a variety of other AMR genes such as aadA5, aph(3''-Ib), aph(6)-Id, aac(3)-IIa, sul1, sul2, dfrA17, dfrA14, qnrB1, tet(A), mph(A), qacE∆, and catB3, which confer resistance to various antibiotics in Enterobacterales isolated from hospital effluents and wastewater treatment plants.
Prevalence and Molecular Characterisation of Extended-Spectrum Beta-Lactamase-Producing Shiga Toxin-Producing Escherichia coli, from Cattle Farm to Aquatic Environments.
The study identified several AMR genes, including sul1, sul2, bla OXA, bla CTX-M, bla TEM, and qnrS, in ESBL-producing STEC isolates from cattle farms and aquatic environments.
Antimicrobial susceptibility and genomic profiling of Salmonella enterica from bloodstream infections at a tertiary referral hospital in Lusaka, Zambia, 2018-2019.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella enterica isolates, including blaTEM-1B, catA1, sul2, sul1, dfrA7, dfrA14, and mutations in gyrA, gyrB, and parC. These resistance mechanisms contribute to multidrug resistance and emerging resistance to ciprofloxacin and cephalosporins.
Genomic Analysis of a Highly Virulent NDM-1-Producing Escherichia coli ST162 Infecting a Pygmy Sperm Whale (Kogia breviceps) in South America.
The study identifies a multidrug-resistant NDM-1-producing E. coli ST162 strain isolated from a pygmy sperm whale, highlighting the presence of various AMR genes including blaNDM-1, blaTEM-1C, blaOXA-1, and others, as well as mutations in gyrA and parC contributing to fluoroquinolone resistance.
Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches.
The study identifies several AMR genes and mutations associated with resistance to various antibiotics in wastewater environments, highlighting the role of these genes in the spread of antimicrobial resistance.
Genetic Analysis of Carbapenem-Resistant Acinetobacter baumannii Isolates from India: Identification of Resistance Islands and Mobile Genetic Elements
This study identified various AMR genes including blaOXA-23, blaNDM-1, aph(3')-Ib, aph(6)-Id, armA, mph, msr, cmlA1, ARR-2, sul1, sul2, tet(B), and blaPER-7 in carbapenem-resistant Acinetobacter baumannii isolates from India. These genes were found to be associated with resistance islands and mobile genetic elements, contributing to the spread of multidrug resistance.
Clustered Regularly Interspaced Short Palindromic Repeats Genotyping of Multidrug-Resistant Salmonella Heidelberg Strains Isolated From the Poultry Production Chain Across Brazil.
The study identified several AMR genes and chromosomal mutations in multidrug-resistant Salmonella Heidelberg strains isolated from the poultry production chain in Brazil, highlighting the widespread distribution of antibiotic-resistant strains.
Assessment of multidrug-resistant Listeria monocytogenes in milk and milk product and One Health perspective.
The study identified multiple antimicrobial resistance genes in Listeria monocytogenes isolates from milk and milk products, including beta-lactamase genes (bla TEM, bla SHV, bla Z), tetracycline resistance genes (tet A, tet D, tet G, tet K, tet M), sulfonamide resistance genes (sul 1, sul 2), and an aminoglycoside resistance gene (aph (3)-IIa (aphA2)).
Calves as Main Reservoir of Antibiotic Resistance Genes in Dairy Farms.
The study identifies calves as the main reservoir of antibiotic resistance genes (ARGs) in dairy farms, highlighting the presence of bla TEM, erm B, sul 2, and tet A, which confer resistance to penicillins, MLS, sulfonamides, and tetracyclines, respectively.
Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates.
The study identified various antimicrobial resistance genes and mutations in Klebsiella pneumoniae bloodstream isolates, highlighting the presence of multidrug-resistant and hypervirulent strains in the United States.
Longitudinal study on background lesions in broiler breeder flocks and their progeny, and genomic characterisation of Escherichia coli.
The study identified several AMR genes in E. coli isolates, including mdfA, sitABCD, blaTEM1B, sul2, dfrA1, tet(A), aadA1, and qnrS1, which conferred resistance to multidrug, beta-lactams, sulfonamides, trimethoprim, tetracycline, aminoglycosides, and quinolones.
Prediction of Antibiotic Susceptibility Profiles of Vibrio cholerae Isolates From Whole Genome Illumina and Nanopore Sequencing Data: CholerAegon.
The study presents CholerAegon, a bioinformatics pipeline for predicting antimicrobial resistance profiles from whole genome sequencing data of Vibrio cholerae. It identifies AMR genes such as dfrA1, sul2, catB9, and floR, and detects mutations like D476N in parE that contribute to fluoroquinolone resistance.
Characterization of NDM-5 Carbapenemase-Encoding Gene (bla (NDM-5)) - Positive Multidrug Resistant Commensal Escherichia coli from Diarrheal Patients.
The study characterizes the bla NDM-5 gene in multidrug-resistant commensal E. coli from diarrheal patients, highlighting its resistance to various antibiotics and its potential for horizontal transfer.
Proposal of a Method for Harmonized Broth Microdilution Antimicrobial Susceptibility Testing of Avibacterium gallinarum.
The study identified several antimicrobial resistance genes in Avibacterium gallinarum, including bla TEM, dfrA14, sul2, tet(B), and tet(H), which confer resistance to various antibiotics such as penicillin, trimethoprim, sulfamethoxazole, and tetracyclines.
Highly Virulent and Multidrug-Resistant Escherichia coli Sequence Type 58 from a Sausage in Germany.
The study identified a highly virulent and multidrug-resistant Escherichia coli strain ST58 from a pork sausage in Germany, carrying resistance genes for beta-lactams, macrolides, streptomycin, sulfonamides, and diaminopyrimidines, along with heavy metal resistance genes.
Molecular Characterization of pBOq-IncQ and pBOq-95LK Plasmids of Escherichia coli BOq 01, a New Isolated Strain from Poultry Farming, Involved in Antibiotic Resistance.
The study characterizes two plasmids, pBOq-IncQ and pBOq-95LK, in the multidrug-resistant E. coli strain BOq 01. pBOq-IncQ carries genes for resistance to sulfonamides and streptomycin, while pBOq-95LK encodes a bleomycin hydrolase, providing resistance to bleomycin. The plasmid pBOq-95LK is a phage-like plasmid that may contribute to the spread of antibiotic resistance genes.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Serotype Diversity and Antimicrobial Resistance Profile of Salmonella enterica Isolates From Freshwater Turtles Sold for Human Consumption in Wet Markets in Hong Kong.
The study identifies the multidrug-resistance gene cfr for the first time in Salmonella, highlighting the expansion of the cfr reservoir and potential horizontal spread to other bacteria. It also detects various AMR genes such as floR, sul2, aph(3')-Ia, aph(3”)-Ib, aph(6)-Id, aac(6')-Ib-cr, bla CMY−2, bla TEM−1, qnrS1, erm(B), mph(E), msr(E), qepA8, arr-3, sul1, dfrA12, dfrA27, tet(A), tet(D), catB3, aadA16, aac(3)-IV, aph(4)-Ia, aadA2, and fosA7.
Whole-genome sequencing-based prediction and analysis of antimicrobial resistance in Yersinia enterocolitica from Ningxia, China.
The study identified several AMR genes in Yersinia enterocolitica isolates from Ningxia, China, including aph(6)-Id, aph(3")-Ib, sul2, tet(A), tet(Y), and y56, which confer resistance to various antibiotics such as ampicillin, streptomycin, trimethoprim/sulfamethoxazole, tetracycline, and others. These genes were validated through whole-genome sequencing and resistance gene prediction.
Whole genome sequencing of the multidrug-resistant Chryseobacterium indologenes isolated from a patient in Brazil.
The study identified multiple antibiotic resistance genes and mutations in a multidrug-resistant Chryseobacterium indologenes strain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and efflux pumps, contributing to resistance against various antibiotics.
Identification and whole-genome sequencing analysis of Vibrio vulnificus strains causing pearl gentian grouper disease in China.
The study identified Vibrio vulnificus EPL 0201 biotype 2 as a multidrug-resistant strain with high pathogenicity, possessing virulence factors vvhA, rtxA, and wza, as well as resistance genes such as H-NS, TEM-1, sul1, tet, floR, parE, mprF, APH(6)-Id, APH(3'')-Ib, aadA16, and arr-3.
Molecular characterisation of Acinetobacter baumannii isolates from bloodstream infections in a tertiary-level hospital in South Africa.
The study identified colistin-resistant Acinetobacter baumannii isolates with resistance genes including bla OXA-23, bla NDM-1, lps B, and various efflux pumps. These isolates exhibited extensive drug resistance (XDR) and were associated with sequence types ST1 and ST2.
Emergence of a Novel NDM-5-Producing Sequence Type 4523 Klebsiella pneumoniae Strain Causing Bloodstream Infection in China.
The study identifies a novel sequence type 4523 Klebsiella pneumoniae strain, ST4523, which is resistant to multiple antibiotics, including carbapenems, and carries the bla NDM-5 gene on a plasmid. The strain also possesses various other resistance genes on plasmids pSHX180-1 and pSHX180-NDM5.
Genomic surveillance of Salmonella spp. in the Philippines during 2013-2014.
The study characterized various AMR genes and mutations in Salmonella isolates from the Philippines, highlighting the presence of ESBL genes, plasmid-mediated quinolone resistance genes, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
High Prevalence of Beta-Lactam-Resistant Escherichia coli in South Australian Grey-Headed Flying Fox Pups (Pteropus poliocephalus).
The study identified various beta-lactam-resistant Escherichia coli strains in South Australian grey-headed flying fox pups, including resistance genes such as blaTEM-1B, blaTEM-1C, blaTEM-33, blaCMY-2, dfrA17, aadA5, dfrA5, sul2, tet(A), tet(B), and catA1.
Genomic characterization of invasive typhoidal and non-typhoidal Salmonella in southwestern Nigeria.
The study identified multiple antibiotic resistance genes and mutations in invasive Salmonella isolates from Nigeria, highlighting the prevalence of multidrug-resistant S. Typhi 3.1.1 and other serovars carrying resistance determinants such as blaTEM-1, aph(3')-Ib, catA1, dfrA14, sul2, tetA, and qnrB19.
Dynamics of Genotypic and Phenotypic Antibiotic Resistance in a Conventional Wastewater Treatment Plant in 2 Years.
The study identified several AMR genes, including beta-lactamases (bla TEM, bla CTX-M-1, bla OXA-1), aminoglycoside resistance genes (strA, strB), sulfonamide resistance genes (sul1, sul2), and tetracycline resistance gene (tetA), in multidrug-resistant bacteria within a wastewater treatment plant over two years.
Prevalence and distribution of extended-spectrum β-lactamase and AmpC-producing Escherichia coli in two New Zealand dairy farm environments.
The study identified bla CMY-2, bla CTX-M-1, bla CTX-M-15, and bla OXA-1 genes in ESBL- and AmpC-producing E. coli isolates from New Zealand dairy farms, highlighting the presence of plasmid-mediated resistance mechanisms.
World Health Organization critical priority Escherichia coli clone ST648 in magnificent frigatebird (Fregata magnificens) of an uninhabited insular environment.
The study identified a multidrug-resistant ST648 E. coli isolate carrying various AMR genes, including blaCTX-M-2, blaCMY-2, qnrB, tetB, sul1, sul2, aadA1, aac(3)-VIa, and mdfA, highlighting the presence of critical priority pathogens in wild birds.
Emergence of uncommon KL38-OCL6-ST220 carbapenem-resistant Acinetobacter pittii strain, co-producing chromosomal NDM-1 and OXA-820 carbapenemases.
The study identifies the co-production of chromosomal NDM-1 and OXA-820 carbapenemases in a carbapenem-resistant Acinetobacter pittii strain, along with other resistance genes such as blaADC-43, ble-MBL, sul2, msr(E), mph(E), and ant(2'')-Ia. A point mutation (S81L) in the gyrA gene was also found, contributing to fluoroquinolone resistance.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Genomic insight into the integrative conjugative elements from ICEHpa1 family.
The study identifies four novel ICEHpa1 variants (ICE Gpa1818, ICE Gpa1808, ICE Gpa1807, and ICE Gpa1815) carrying diverse resistance genes, including tetracycline, streptomycin, gentamicin, sulfamethoxazole/trimethoprim, florfenicol, and amoxicillin resistance genes.
Urban rats as carriers of invasive Salmonella Typhimurium sequence type 313, Kisangani, Democratic Republic of Congo.
The study identified multidrug-resistant Salmonella Typhimurium ST313 in urban rats in Kisangani, Democratic Republic of Congo, highlighting their potential role as reservoirs of invasive Salmonella. The resistant isolates carried genes such as blaTEM-1, strA, strB, ant(3')-Ia, aac(3')-IId, sul1, sul2, dfrA1, tetB, and catA10, conferring resistance to multiple antibiotics.
Molecular epidemiology and carbapenem resistance characteristics of Acinetobacter baumannii causing bloodstream infection from 2009 to 2018 in northwest China.
The study identified multiple carbapenem resistance genes, including blaOXA-23 and blaOXA-72, along with other resistance mechanisms such as 16S rRNA methylase armA and aminoglycoside-modifying enzymes. The AdeABC efflux pump was also found to contribute to carbapenem resistance.
Phenotypic and Genotypic Analysis of Antimicrobial Resistance in Escherichia coli Recovered from Feedlot Beef Cattle in Australia.
The study identified several AMR genes in E. coli from feedlot beef cattle, including tet(B), aph(3"-Ib, aph(6)-Id, bla TEM-1B, sul2, bla TEM, bla CTX m, and bla CMY, which confer resistance to tetracyclines, aminoglycosides, beta-lactams, and sulfonamides.
Whole-genome sequencing-based characteristics of Escherichia coli Rize-53 isolate from Turkey.
The study identified ten antibiotic resistance genes in the E. coli Rize-53 isolate, including blaOXA-1, blaOXA-2, aac(6')-II, aac(6')-Ib-cr, tetB, catB3, qacE, sitABCD, mdfA, and sul2, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, chloramphenicol, sulfonamides, and quaternary ammonium compounds.
Genomic characteristics of clinical multidrug-resistant Proteus isolates from a tertiary care hospital in southwest China.
The study identifies multiple AMR genes in clinical multidrug-resistant Proteus isolates, including bla CTX-M-65, bla OXA-1, bla KPC-2, bla NDM-1, and others, highlighting the genetic diversity of mobile genetic elements carrying resistance genes.
Occurrence of Shiga toxin-producing Escherichia coli carrying antimicrobial resistance genes in sheep on smallholdings in Bangladesh.
The study identified the presence of antimicrobial resistance genes bla TEM, sul1, and sul2 in Shiga toxin-producing Escherichia coli (STEC) isolates from sheep in Bangladesh.
Molecular epidemiology and antibiotic resistance profiles of invasive Haemophilus influenzae from Norway 2017-2021.
The study identified bla TEM–1, rPBP3, catA2, tet(B), sul2, aph(3')-Ia, strA, and strB as significant antibiotic resistance genes in invasive Haemophilus influenzae isolates from Norway. Mutations in PBP3, GyrA, and ParC were also associated with resistance to beta-lactams and quinolones.
Phylotypic Profiling, Distribution of Pathogenicity Island Markers, and Antimicrobial Susceptibility of Escherichia coli Isolated from Retail Chicken Meat and Humans.
The study identified several antimicrobial resistance genes, including sul2, blaTEM, qnrA, dfrA1, and aphA1, in Escherichia coli isolates from retail chicken meat and human urinary tract infections. These genes conferred resistance to various antibiotics such as penicillin, sulfonamides, quinolones, and aminoglycosides.
Occurrence of Antimicrobial-Resistant Escherichia coli in Marine Mammals of the North and Baltic Seas: Sentinels for Human Health.
The study identified antimicrobial-resistant Escherichia coli in marine mammals from the North and Baltic Seas, highlighting the presence of resistance genes such as blaTEM, strA, strB, aadA1, sul1, sul2, tet(A), tet(B), tet(D), qnrS, floR, catA1, blaOXA-1-like, blaSHV, and blaCMY-2.
Emergence of Extensively Drug-Resistant ST170 Citrobacter portucalensis with Plasmids pK218-KPC, pK218-NDM, and pK218-SHV from a Tertiary Hospital, China.
The study identifies the emergence of an extensively drug-resistant Citrobacter portucalensis strain, K218, which carries multiple resistance genes including bla KPC-2 and bla NDM-1, contributing to its multidrug-resistant phenotype.
Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Strains Recovered from Chilean Hospitals Reveals Lineages Specific to South America and Multiple Routes for Acquisition of Antibiotic Resistance Genes.
The study identifies various AMR genes in carbapenem-resistant Acinetobacter baumannii strains from Chile, including blaTEM, aacC2, aphA6, sul1, sul2, catA1, tetA(A), aadA1, dfrA1, strAB, cmlB1, floR, oxa58, and oxa23, highlighting the diversity of resistance mechanisms and the role of mobile genetic elements in their dissemination.
Antimicrobial resistance of Salmonella Indiana from retail chickens in China and emergence of an mcr-1-harboring isolate with concurrent resistance to ciprofloxacin, cefotaxime, and colistin.
The study identified multiple AMR genes in Salmonella Indiana isolates, including bla CTX-M-65, bla CTX-M-14, bla CTX-M-27, bla CTX-M-28, bla CTX-M-79, aac(6')-Ib-cr, oqxAB, and mcr-1, which contribute to resistance against various antibiotics.
Clinical Efficacy, Antibiotic Resistance Genes, Virulence Factors and Outcome of Hospital-Acquired Pneumonia Induced by Klebsiella pneumoniae Carbapenemase 2-Producing with Tigecycline Treatment in the ICU.
The study identified several antibiotic resistance genes, including blaKPC-2, blaSHV, blaCTX-M, blaTEM, and aac3iia, which are associated with resistance to various antibiotics. Additionally, virulence factors such as AREO-iutA and Capsule-wzc were found to be independently associated with mortality in patients with KPC-KP infections.
Acquisition of genomic elements were pivotal for the success of Escherichia coli ST410
The study identified several AMR genes and mutations in Escherichia coli ST410, including bla OXA-181, bla NDM-5, bla CTX-M-15, and mutations in gyrA, parC, and parE that confer resistance to carbapenems, cephalosporins, penicillins, aminoglycosides, sulfonamides, trimethoprim, and fluoroquinolones.
Genome-wide analysis reveals the emergence of multidrug resistant Stenotrophomonas acidaminiphila strain SINDOREI isolated from a patient with sepsis.
The study identifies multiple antibiotic resistance genes in the multidrug-resistant Stenotrophomonas acidaminiphila strain SINDOREI, including sul1, sul2, qnr, GES-1, aadA3, qacL, cmlA5, and tetC, which confer resistance to trimethoprim/sulfamethoxazole, fluoroquinolone, beta-lactam, aminoglycoside, disinfecting agents, phenicol, and tetracycline.
Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based bla (CTX-M-15) and one rmpA2-associated virulence plasmid.
The study characterizes an OXA-232-producing ST15 CRKP strain with a multidrug-resistant profile, harboring chromosomal bla CTX-M-15 and plasmid-mediated bla OXA-232, along with other resistance genes such as strAB, rmtF, sul2, dfrA14, qnrB1, arr-2, and catB. Mutations in gyrA (S83F) and parC (S80I) contribute to fluoroquinolone resistance.
Human pandemic K27-ST392 CTX-M-15 extended-spectrum β-lactamase-positive Klebsiella pneumoniae: A one health clone threatening companion animals.
The study identifies a multidrug-resistant K. pneumoniae strain (LCKp01) carrying the bla CTX-M-15 gene and other clinically important AMR genes, highlighting the global spread of this clone in both human and animal populations.
Emergence of a Novel Lineage and Wide Spread of a bla(CTX-M-15)/IncHI2/ST1 Plasmid among Nosocomial Enterobacter in Guadeloupe.
The study identifies the bla CTX-M-15 gene as the most prevalent ESBL determinant in ESBL-producing Enterobacter cloacae complex isolates, along with the IncHI2/ST1 plasmid. It also reports the presence of other resistance genes such as mcr-9, aac(3)-IIa, aac(6′)-Ib-cr, aph(3″)-Ib, aph(6)-Id, bla OXA-1, bla TEM-1B, qnrB1, fosA, sul2, tet(A), dfrA14, ars, mer, tni, and the ter operon.
Whole genome sequencing and characteristics of extended-spectrum beta-lactamase producing Escherichia coli isolated from poultry farms in Banaskantha, India.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla TEM, bla SHV, bla OXA, and bla CTX-M subtypes, along with plasmid-mediated AMR genes such as qnrS1, tetA, dfrA14, sul2, aph(3")-lb, aph(6)-ld, and Aph(3')-la in ESBL-producing E. coli isolates from poultry farms in India.
Isolation of extended-spectrum β-lactamase-producing Escherichia coli from Japanese red fox (Vulpes vulpes japonica).
Two CTX-resistant Escherichia coli strains were isolated from Japanese red fox fecal samples, harboring various AMR genes and mutations. One strain carried aph(3")-Ib, aph(3')-Ia, aph(6)-Id, mdf(A), sitABCD, sul2, tet(A), and tet(B), while the other had gyrA(S83L), parC(S80I, E84V), and parE(I529L) mutations along with mdf(A) and sitABCD.
Mobile genetic elements in Acinetobacter antibiotic-resistance acquisition and dissemination.
The study highlights the role of mobile genetic elements, particularly insertion sequences (IS), in the acquisition and dissemination of antibiotic resistance in Acinetobacter species. IS elements can enhance the expression of intrinsic beta-lactamase genes, such as bla OXA-23, bla OXA-51, and ampC, leading to carbapenem and cephalosporin resistance. Additionally, IS elements can disrupt genes involved in antibiotic uptake, such as porins, and alter the expression of efflux pumps, contributing to multidrug resistance.
Pathogenome comparison and global phylogeny of Escherichia coli ST1485 strains.
The study identifies multiple antibiotic resistance genes, including blaTEM-1, aph(3')-Ib, aph(6)-Id, sul2, dfrA14, and mcr-1, in Escherichia coli ST1485 strains, highlighting their multidrug-resistant nature and potential zoonotic risk.
Genomic Analysis and Molecular Characteristics in Carbapenem-Resistant Klebsiella pneumoniae Strains.
The study identified several AMR genes, including bla KPC-2, bla SHV-11, bla TEM-1, CTX-M, qnrS, oqxB1, sul1, sul2, int1, iutA, and rmpA2, in carbapenem-resistant Klebsiella pneumoniae strains.
Multistate reptile- and amphibian-associated salmonellosis outbreaks in humans, United States, 2009-2018.
The study identified various AMR genes and mutations in Salmonella isolates from multistate reptile- and amphibian-associated salmonellosis outbreaks in the United States, including bla CMY-2, qnrB19, qnrS1, bla TEM-116, bla TEM-1C, bla TEM-1B, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, sul1, sul3, floR, tet(A), and sul2, which conferred resistance to multiple antibiotics such as ciprofloxacin, ceftriaxone, ampicillin, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline.
Whole-Genome Sequencing-Based Species Classification, Multilocus Sequence Typing, and Antimicrobial Resistance Mechanism Analysis of the Enterobacter cloacae Complex in Southern China.
The study identified 80 antibiotic resistance genes in 172 Enterobacter cloacae complex isolates, with a focus on beta-lactamases, aminoglycosides, and fluoroquinolones. Key genes included blaACT-2, blaACT-3, blaACT-6, blaACT-9, blaACT-12, blaTEM-1D, blaCTX-M-3, blaSHV-12, blaNDM-1, blaNDM-5, blaIMP-1, blaIMP-4, blaIMP-26, blaKPC-2, qnrS2, qnrE1, aac(6')-Ib, aac(6')-IIc, aph(3')-Ib, aph(6)-Id, aadA, sul2, dfrA12, tetA, ereA, floR, catA2, mcr-10, arr-6, and fosA3.
Genomic Study of Chromosomally and Plasmid-Mediated Multidrug Resistance and Virulence Determinants in Klebsiella Pneumoniae Isolates Obtained from a Tertiary Hospital in Al-Kharj, KSA.
The study identified several AMR genes in K. pneumoniae isolates, including blaOXA-1, blaCTX-M-3, blaOXA-232, catB3, aac(6')-Ib-cr, dfrA14, IntI1, IS1, RepE, qnrB4, qnrB55, qnrS1, aph(3")-Ib, sul2, aadA2, SHV-190, SHV-26, SHV-11, tet(A), fosA, OqxA, and OqxB, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, trimethoprim, quinolones, sulfonamides, and fosfomycin.
Vaginal Bacteria in Mares and the Occurrence of Antimicrobial Resistance.
The study identified several AMR genes in E. coli isolates from mares, including dfrA14 for trimethoprim resistance, mdf(A) for chloramphenicol resistance, sul2 for sulfonamide resistance, blaEC for beta-lactam resistance, and aph(6)-Id for streptomycin resistance.
Characterization of antibiotic-resistance traits in Akkermansia muciniphila strains of human origin.
The study identified several AMR genes in Akkermansia muciniphila strains, including adeF, tetW, sul2, and aph(6)-Id. Only the strain Amap1 showed resistance to tetracycline due to the presence of tetW. The presence of ARGs does not always translate into a resistant phenotype.
Conjugative transfer of multi-drug resistance IncN plasmids from environmental waterborne bacteria to Escherichia coli.
The study identified the transfer of multi-drug resistance IncN plasmids from environmental waterborne bacteria to E. coli, highlighting the presence of sulfonamide resistance genes sul1 and sul2 in transconjugants.
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
The study identified ESBL-producing E. coli in river water in northern Thailand, with bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27 being the most prevalent beta-lactamase genes. Additionally, mcr-1.1 and mcr-3.4 genes were found to confer resistance to colistin. Various other resistance genes were also characterized, including aac(3)-IId, aadA5, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, aac(6′)-Ib-cr, qnrS1, mdf(A), erm(B), mph(A), floR, sul2, sul3, tet(A), tet(X), tet(M), dfrA12, dfrA14, dfrA17, cmlA1, catA2, lnu(F), and erm(42).
Antimicrobial resistance and genomic characterization of Salmonella enterica serovar Senftenberg isolates in production animals from the United States.
The study characterized antimicrobial resistance genes and mutations in Salmonella enterica serovar Senftenberg isolates from production animals in the United States, identifying genes such as aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, blaTEM-1B, blaCMY-2, blaSHV-12, floR, catA2, qnrB2, aac(6')-Ib-cr, aadA1, aadA2, sul1, sul2, tetA, and mcr-9.1, along with mutations in gyrA and parC genes contributing to resistance against various antibiotics.
Molecular Characterization and the Antimicrobial Resistance Profile of Salmonella spp. Isolated from Ready-to-Eat Foods in Ouagadougou, Burkina Faso.
The study identified several antimicrobial resistance genes in Salmonella isolates from ready-to-eat foods in Burkina Faso, including blaTEM, temB, sul1, sul2, aadA, tet(A), and tet(B). These genes confer resistance to various antibiotics such as ampicillin, cefoxitin, trimethoprim/sulfamethoxazole, and tetracycline.
Distribution Patterns of Antibiotic Resistance Genes and Their Bacterial Hosts in a Manure Lagoon of a Large-Scale Swine Finishing Facility.
The study identified multiple antibiotic resistance genes (ARGs) in manure samples from a swine finishing facility, highlighting the prevalence of resistance to tetracyclines, macrolides, aminoglycosides, and other antibiotics. Key genes included tet(M), lnuA, erm(35), aadS, mphB, dfrG, vga-type ABC-F, lsa-type ABC-F, msr-type ABC-F, optrA, and others, primarily found in Firmicutes, Proteobacteria, and Bacteroidota. These genes were associated with resistance mechanisms such as target alteration, antibiotic inactivation, and efflux pumps.
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
The hazard of carbapenemase (OXA-181)-producing Escherichia coli spreading in pig and veal calf holdings in Italy in the genomics era: Risk of spill over and spill back between humans and animals.
The study identifies multiple AMR genes, including bla OXA-181, bla TEM-1B, aac (3)-IId, aad A2, cml A1, dfr A12, mef (B), sul 3, tet (A), tet (M), incX3, incX1, incFII, qnr S1, aph (3″)-Ib, aph (6)-Id, flo R, lnu (F), sul 2, sul 3, tet (B), mph (A), mph (G), qnr B4, rmt B, and fos A3, in OXA-181-producing E. coli isolates from pigs and bovines in Italy. These genes confer resistance to various antibiotics, including carbapenems, cephalosporins, penicillins, aminoglycosides, trimethoprim, macrolides, sulfonamides, tetracyclines, fluoroquinolones, and fosfomycin.
Impact of international travel and diarrhea on gut microbiome and resistome dynamics.
The study identifies several antimicrobial resistance genes, including blaTEM-148, sul2, aph6, and tetA, in diarrheagenic Escherichia coli isolates from international travelers, highlighting the increased resistance gene diversity associated with diarrhea.
Coexistence of Multidrug Resistance and Virulence in a Single Conjugative Plasmid from a Hypervirulent Klebsiella pneumoniae Isolate of Sequence Type 25.
The study identifies a conjugative plasmid pCY814036-iucA carrying multidrug resistance genes and virulence factors, and another plasmid pCY814036-KPC2 harboring bla KPC-2 and rmtB, contributing to carbapenem resistance and hypervirulence in a Klebsiella pneumoniae isolate.
Molecular Characterization of Salmonella spp. Isolates from Wild Colombian Babilla (Caiman crocodilus fuscus) Isolated In Situ.
The study identified multiple antibiotic resistance genes in Salmonella isolates from wild Colombian babilla, including blaTEM, strB, sul1, blaCMY2, blaCTX-M, sul2, dfrA1, floR, and qnrD, indicating the potential of these reptiles as carriers of multidrug-resistant bacteria.
Mobile colistin resistance (MCR), extended-spectrum beta-lactamase (ESBL) and multidrug resistance monitoring in Escherichia coli (commensal and pathogenic) in pig farming: need of harmonized guidelines and clinical breakpoints.
The study identified mcr-1 and mcr-4 genes conferring colistin resistance, along with blaTEM-1B, aph(3")-Ib, aph(6)-Id, sul2, and tet(A) genes responsible for resistance to various antibiotics in E. coli isolates from pig farming.
Rothia nasimurium as a Cause of Disease: First Isolation from Farmed Chickens.
Rothia nasimurium was isolated from chickens for the first time and found to exhibit multidrug resistance, carrying 13 resistance genes including bla TEM, bla CTX-M, mecA, sul1, sul2, sul3, aac(6′)-Ib, gyrA, aph(3′)-Ia, tet(A), tetM, and ermB.
In Vitro Assessment of Antimicrobial Activity of Phytobiotics Composition towards of Avian Pathogenic Escherichia coli (APEC) and Other E. coli Strains Isolated from Broiler Chickens.
The study identifies several AMR genes in E. coli strains, including aadA, strA/strB, aphA1, aphA2, tetA, tetB, sul1, sul2, sul3, dfrA1, dfrA10, dfrA12, floR, and blaSHV, which confer resistance to various antibiotics such as streptomycin, neomycin, tetracycline, sulfonamides, trimethoprim, chloramphenicol, and cephalosporins.
Genomic Analysis of Klebsiella pneumoniae ST258 Strain Coproducing KPC-2 and CTX-M-14 Isolated from Poultry in the Brazilian Amazon Region.
The study characterizes a multidrug-resistant Klebsiella pneumoniae ST258 strain (KP411) isolated from poultry in the Brazilian Amazon, which carries several AMR genes including blaKPC-2, blaCTX-M-14, and others, highlighting the potential of food-producing animals as reservoirs of MDR clones.
A Familiar Outbreak of Monophasic Salmonella serovar Typhimurium (ST34) Involving Three Dogs and Their Owner's Children.
The study identified AMR genes sul2, tetB, and blaTEM-1B in a monophasic Salmonella Typhimurium ST34 outbreak involving humans and dogs.
Genomic Characterization of ESBL/AmpC-Producing Escherichia coli in Stray Dogs Sheltered in Yangzhou, China.
The study identified several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-55, and others, along with additional resistance genes such as tet(A), qnrS1, and oqxAB, contributing to multidrug resistance in ESBL/AmpC-producing E. coli isolated from stray dogs in Yangzhou, China.
Salmonella Heidelberg and Salmonella Minnesota in Brazilian broilers: Genomic characterization of third-generation cephalosporin and fluoroquinolone-resistant strains.
The study identifies multiple AMR genes and mutations in Salmonella Heidelberg and Salmonella Minnesota isolates from Brazilian broilers, including bla CMY-2, qnrB19, aac(6')-Iaa, sul2, tet(A), fosA7, qacE, and formA, along with gyrA(S83F) and parC(T57S) mutations conferring resistance to various antibiotics.
Molecular and Clinical Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Isolates at a Tertiary Hospital in Wuhan, China.
The study identified multiple carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates carrying various resistance genes, including blaKPC-1, blaCTX-M-65, blaTEM-1, blaSHV-182, rmtB, aadA2, APH(3')-Ia, sul1, sul2, QnrS1, mphA, FosA6, floR, and tet(A). These genes confer resistance to carbapenems, beta-lactams, aminoglycosides, sulfonamides, fluoroquinolones, macrolides, fosfomycin, chloramphenicol, and tetracyclines.
Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb.
The study identified several AMR genes in multidrug-resistant bacteria isolated from a COVID-19 hospital in Zagreb, including bla CTX-M-15 in E. coli and various bla OXA variants in A. baumannii. These genes conferred resistance to beta-lactams and aminoglycosides.
Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009-2018.
The study identifies multiple AMR genes associated with multidrug-resistant Salmonella enterica serotype 4,[5],12:i:-, including genes conferring resistance to ampicillin, streptomycin, sulfamethoxazole, tetracycline, ciprofloxacin, ceftriaxone, azithromycin, and colistin. These genes are prevalent in a multidrug-resistant clade linked to pork consumption.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Enhance antibiotic resistance and human health risks in aerosols during the COVID-19 pandemic.
The study identified increased abundances of antibiotic resistance genes (ARGs) in aerosols during the COVID-19 pandemic, particularly sulfonamide (sul1, sul2), tetracycline (tetA, tetC), and beta-lactam (ampC) resistance genes. These genes were associated with heightened antibiotic resistance in airborne bacteria, contributing to elevated human health risks.
Prevalence and abundance of antibiotic-resistant genes in culturable bacteria inhabiting a non-polar passu glacier, karakorum mountains range, Pakistan.
The study identified multiple antibiotic-resistant genes (ARGs) in culturable bacteria from a non-polar glacier in Pakistan, highlighting the presence of resistance mechanisms against various antibiotics.
The fate of sulfonamide resistance genes and anthropogenic pollution marker intI1 after discharge of wastewater into a pristine river stream.
The study identifies and characterizes several sulfonamide resistance genes (sul1, sul2), the integrase gene intI1, and various other antibiotic resistance genes (ARGs) such as aadA2, aadA11, blaOXA-2, blaOXA-4, blaOXA-10, blaOXA-33, blaOXA-36, blaOXA-129, blaOXA-392, blaOXA-824, blaBEL-1, blaGES-11, ereA2, cmlA5, dfrA1, and qacL. These genes were found in the class 1 integron gene cassettes in the Holtemme river, highlighting the persistence of ARGs downstream from wastewater treatment plant discharge.
In silico analyses of diversity and dissemination of antimicrobial resistance genes and mobile genetics elements, for plasmids of enteric pathogens.
The study identifies a diverse array of antimicrobial resistance (AMR) genes across various plasmid replicon types in enteric pathogens, highlighting the prevalence of resistance genes in plasmids such as IncHI2, IncN, IncA/C, IncP, IncHI1, and IncFIA. Key AMR genes include aac(3)-IId, aac(3)-IIg, aac(6')-Ib3, aadA1, aadA5, aph(3'')-Ib, bla CMY-2, bla CTX-M-27, bla NDM-1, mcr-9.1, and others, which confer resistance to antibiotics such as gentamicin, cephalosporins, carbapenems, colistin, and tetracycline.
Fusion plasmid enhanced the endemic extensively drug resistant Klebsiella pneumoniae clone ST147 harbored bla(OXA-48) to acquire the hypervirulence and cause fatal infection.
The study identifies the emergence of XDR-ST147-hvKp, which harbors bla(OXA-48) and exhibits hypervirulence, leading to fatal infections. It also reports the presence of diverse genetic contexts for bla CTX-M-15, including chromosomal integration.
Silver nanoparticles enhance the efficacy of aminoglycosides against antibiotic-resistant bacteria.
The study identifies several AMR genes, including mcr-1, mcr-3, mcr-4, aadA5, catA1, bla CMY-2, bla CTX-M-55, dfrA17, fosA, mph(A), rmtB, strA, strB, sul1, sul2, bla TEM-1B, and bla CMY-48, which confer resistance to various antibiotics in different bacterial strains.
Genetic Organization of Acquired Antimicrobial Resistance Genes and Detection of Resistance-Mediating Mutations in a Gallibacterium anatis Isolate from a Calf Suffering from a Respiratory Tract Infection.
The study identified multiple acquired antimicrobial resistance genes and resistance-mediating mutations in a Gallibacterium anatis isolate from a calf with a respiratory tract infection, highlighting the potential for this bacterium to serve as a reservoir for antimicrobial resistance genes.
Longitudinal study of the short- and long-term effects of hospitalisation and oral trimethoprim-sulfadiazine administration on the equine faecal microbiome and resistome.
Oral trimethoprim-sulfadiazine (TMS) administration leads to a significant and long-lasting increase in the relative abundance of resistance genes sul2, tetQ, ant6-1a, aph(3"-lb, and lnuC in the equine faecal microbiome.
Emergence of colistin resistance and characterization of antimicrobial resistance and virulence factors of Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae isolated from hybrid red tilapia cage culture.
The study identified several AMR genes in Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae isolated from hybrid red tilapia. Notably, mcr-3 was found in A. hydrophila, and qnrS, tetA, blaTEM, and floR were prevalent in Salmonella spp. No colistin resistance genes were detected in V. cholerae.
Multidrug-resistant extended spectrum β-lactamase (ESBL)-producing Escherichia coli from farm produce and agricultural environments in Edo State, Nigeria.
The study identified various AMR genes in ESBL-producing E. coli isolates from agricultural farms and open markets in Edo State, Nigeria, including blaTEM, blaCTX-M-1, blaCTX-M-15, tetM, tetA, tetB, sul1, sul2, sul3, ant(4')-Ia, aacC(3)-1, qnrA, qnrB, qnrC, qnrS, cat::pC194, cat::pC221, intI1, and intI2. These genes conferred resistance to multiple antibiotics, indicating the presence of multidrug-resistant E. coli in the studied environments.
Genomic analyses of drug-resistant Salmonella enterica serovar Heidelberg strains isolated from meat and related sources between 2013 and 2017 in the south region of Brazil.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella enterica serovar Heidelberg strains, including fosA7, aac(6')-Iaa, sul2, tet(A), bla CMY-2, mdsA, mdsB, and point mutations in gyrA and parC, indicating a multidrug-resistant profile.
Enterobacterales plasmid sharing amongst human bloodstream infections, livestock, wastewater, and waterway niches in Oxfordshire, UK.
The study identifies various AMR genes, including bla TEM-1, aph(3'')-Ib, aph(6)-Id, dfrA5, sul2, and robA, which are associated with plasmids shared among human bloodstream infections, livestock, wastewater, and waterways in Oxfordshire, UK.
Phenotypic and genotypic survey of antibiotic resistance in Salmonella enterica isolates from dairy farms in Uruguay.
The study identified 21 AMR genes in Salmonella enterica isolates from dairy farms in Uruguay, including genes conferring resistance to aminoglycosides, tetracyclines, sulfonamides, beta-lactams, and quinolones. Two chromosomal mutations, parC_T57S and acrB_R717Q, were also detected, contributing to resistance against quinolones and azithromycin, respectively.
Analysis of Antimicrobial Resistance Genes (ARGs) in Enterobacterales and A. baumannii Clinical Strains Colonizing a Single Italian Patient.
The study identified various antimicrobial resistance genes in Enterobacterales and A. baumannii clinical strains from a single patient, highlighting the presence of blaNDM-1, qnrS1, aadA1, strA-strB, sul2, tet(J), catA1, blaACT-15, blaTEM-1B, dfrA14, oqxB, fosA, blaLEN-22, blaOXA-23, blaADC-25, blaOXA-66, armA, mph(E), msr(E), and tetB, indicating multidrug resistance and potential for horizontal gene transfer.
Genomic Diversity, Antimicrobial Susceptibility, and Biofilm Formation of Clinical Acinetobacter baumannii Isolates from Horses.
The study identified multiple AMR genes in equine Acinetobacter baumannii isolates, including beta-lactamases (bla OXA-51-like, bla ADC-25, bla TEM-1D), sulfonamide resistance genes (sul1, sul2), chloramphenicol resistance genes (catA1, ABUW 0982), tetracycline resistance genes (tet(A), tet(B), tet(39)), and aminoglycoside modifying enzymes (aph(3′)-Ia, aph(3`)-Ic, aph(6)-Id, aac(3)-Ia). Additionally, eight novel OXA-51-like variants (OXA-970 to OXA-977) were characterized.
Association of ISVsa3 with Multidrug Resistance in Salmonella enterica Isolates from Cattle (Bos taurus).
The study found that multidrug resistance (MDR) in Salmonella enterica isolates from cattle is strongly associated with the presence of IS Vsa3, an IS91-like transposase. The MDR genes, including floR, tet(A), aph(6)-Id, aph(3"-Ib, sul2, and bla CMY-2, were often located on IncC plasmids carrying IS Vsa3.
Antimicrobial Resistance in Vaginal Bacteria in Inseminated Mares.
The study identified several AMR genes in E. coli, S. equisimilis, and S. simulans, including sul1, sul2, dfrA1, dfrA14, tet(A), mdf(A), blaEC-5, blaTEM-1, blaTEM-1B, blaEC, catB3, aadA5, aph(6)-ld, lsaC, and blaZ, which conferred resistance to various antibiotics.
Prevalence and Characterization of Salmonella Isolated from Chickens in Anhui, China.
The study identified several AMR genes in Salmonella isolates from chickens in Anhui, China, including blaTEM, blaCMY-2, aadA, strA, aph(3')-IIa, aac(6')-Ib-cr, qnrB, qnrS, sul1, sul2, tetA, tetB, cat1, and floR. These genes were associated with resistance to various antibiotics such as ampicillin, cephalosporins, streptomycin, gentamicin, amikacin, fluoroquinolones, sulfamethoxazole, tetracycline, chloramphenicol, and florfenicol.
The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China.
The study identifies multiple antimicrobial resistance genes in Salmonella enterica isolates from China, highlighting the increasing prevalence of resistance to beta-lactams, quinolones, tetracyclines, and sulfonamides. Key genes include blaTEM-1B, blaCTX-M-14, aac(3)-IV, and mcr-1.
High frequency of NDM-1 and OXA-48 carbapenemase genes among Klebsiella pneumoniae isolates in central Iran.
The study identified high frequencies of bla TEM, bla CTX-M1, bla SHV, bla CTX-M15, bla CIT, bla CMY-2, bla NDM, bla OXA-48, qnrB, qnrS, qnrA, tetA, tetB, sul1, sul2, int1, and int2 genes in Klebsiella pneumoniae isolates from central Iran, highlighting the prevalence of multidrug-resistant and carbapenem-resistant strains.
Prevalence and Genomic Characteristics of mcr-Positive Escherichia coli Strains Isolated from Humans, Pigs, and Foods in China.
The study identified mcr-1 as a major gene conferring colistin resistance in Escherichia coli isolates from humans, pigs, and foods in China. Additionally, several other resistance genes such as tet(A), floR, sul2, aadA1, strA, strB, blaCTX-M-14, fosA, lnu(F), and arr-3 were found to confer resistance to various antibiotics.
Dissemination of Pseudomonas aeruginosa bla(NDM-1)-Positive ST308 Clone in Singapore.
The study identifies multiple antibiotic resistance genes (ARGs) in bla NDM-1 -positive P. aeruginosa ST308 isolates, including aac(3)-Id, aac(6′)-Il, aph(3′)-Iib, bla OXA-488, bla NDM-1, bla PDC-19a, catB7, crpP, fosA, msr(E), qnrVC1, sul2, dfrB5, floR, aadA6, aadA11, and aph(3″)-Ib. These genes confer resistance to various antibiotics such as aminoglycosides, beta-lactams, carbapenems, cephalosporins, chloramphenicol, fluoroquinolones, fosfomycin, macrolides, quinolones, sulfonamides, trimethoprim, and streptomycin.
Antimicrobial resistance and genomic characterization of Salmonella enterica isolates from chicken meat.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from chicken meat, including aminoglycoside, beta-lactam, quinolone, tetracycline, sulfonamide, and phenicol resistance genes. These genes were detected using whole genome sequencing and correlated with phenotypic resistance profiles.
High Genetic Diversity of Carbapenem-Resistant Acinetobacter baumannii Isolates Recovered in Nigerian Hospitals in 2016 to 2020.
The study identified blaOXA-23 and blaNDM-1 as the most common carbapenem resistance genes in Acinetobacter baumannii isolates from Nigerian hospitals, along with several other AMR genes and mutations contributing to multidrug resistance.
Phenotypic and Genotypic Characteristics of Antimicrobial Resistance in Citrobacter freundii Isolated from Domestic Ducks (Anas platyrhynchos domesticus) in Bangladesh.
The study identified multiple AMR genes in Citrobacter freundii isolates from domestic ducks in Bangladesh, including beta-lactamases (bla TEM-1, bla CMY-2, bla CMY-9, bla CTX-M-14), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tetA, tetB), fluoroquinolone resistance genes (qnrA, qnrB, qnrS), and an aminoglycoside resistance gene (aacC4).
Occurrence of High-Risk Clonal Lineages ST58, ST69, ST224, and ST410 among Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Healthy Free-Range Chickens (Gallus gallus domesticus) in a Rural Region in Tunisia.
The study identified high-risk clonal lineages ST58, ST69, ST224, and ST410 among ESBL-producing E. coli isolates from free-range chickens in Tunisia. Key AMR genes included bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, aac(6')-Ib-cr, qnrS, qnrB, tetB, tetA, sul1, sul2, and mcr-2.
Antibiotic-Resistant Vibrio cholerae O1 and Its SXT Elements Associated with Two Cholera Epidemics in Kenya in 2007 to 2010 and 2015 to 2016.
The study identified antibiotic resistance genes dfrA1, sul2, strA, strB, and floR in Vibrio cholerae O1 strains from two cholera epidemics in Kenya. Chromosomal mutations in gyrA (Ser83Ile) and parC (Ser85Leu) were associated with nalidixic acid resistance.
Investigating Possible Interspecies Communication of Plasmids Associated with Transfer of Third-Generation Cephalosporin, Quinolone, and Colistin Resistance Between Simultaneously Isolated Escherichia Coli and Klebsiella Pneumoniae.
The study identified multiple AMR genes in E. coli and K. pneumoniae isolates, including bla CTX-M-14, qnrS1, mcr-1.1, and others, highlighting the role of plasmids in the transfer of resistance genes between species.
The evolutionary tale of eight novel plasmids in a colistin-resistant environmental Acinetobacter baumannii isolate.
The study identifies a novel variant of the mcr-4 colistin resistance gene (mcr-4.7) in a transposon on a plasmid in an environmental Acinetobacter baumannii isolate, as well as the sul2 sulfonamide resistance gene in a p dif module.
Within-patient and global evolutionary dynamics of Klebsiella pneumoniae ST17.
The study identified the presence of the bla CTX-M-15 gene, which confers resistance to extended-spectrum beta-lactams, along with other AMR genes such as aac(3)-IIa, bla TEM1-D, strAB, dfrA14, sul2, and catA2 in Klebsiella pneumoniae ST17. The yersiniabactin gene was also found to be present in the genomes.
Molecular epidemiology of enterically colonizing Escherichia coli with resistance against third-generation cephalosporins isolated from stool samples of European soldiers with concomitant diarrhea on deployment in Western African Mali.
The study identified bla CTX-M-15 and bla TEM-1b as the primary genes responsible for third-generation cephalosporin resistance in E. coli isolates from European soldiers in Mali. Additionally, several quinolone resistance genes including qnrS1, gyrA S83L, gyrA D87N, parE S458T, parE S458A, and parC S80I were found. Trimethoprim-sulfamethoxazole resistance was mediated by sul1, sul2, dfrA1, dfrA5, dfrA14, and dfrA17. Gentamicin resistance was associated with aph6-Id, aph3-Ib, aac3-IId, aadA5, and aac6-Ib-cr5. Tetracycline resistance was conferred by tetA, tetB, and tetD.
Antimicrobial resistance and molecular characterization of Escherichia coli isolated from bovine mastitis samples in Nghe An province, Vietnam.
The study identified tetracycline resistance genes tetA and tetB, sulfonamide resistance genes sul1 and sul2, and no extended-spectrum beta-lactamase (ESBL) genes in E. coli isolates from bovine mastitis in Vietnam.
Prevalence and Persistence of Antibiotic Resistance Determinants in the Gut of Travelers Returning to the United Kingdom is Associated with Colonization by Pathogenic Escherichia coli.
The study identified various antibiotic resistance genes in the gut microbiota of travelers returning to the UK, highlighting the association with colonization by pathogenic E. coli. Key findings include the prevalence of genes conferring resistance to macrolides, tetracyclines, sulfonamides, and others.
Escherichia coli ST2797 Is Abundant in Wastewater and Might Be a Novel Emerging Extended-Spectrum Beta-Lactamase E. coli.
The study identifies E. coli ST2797 as a multidrug-resistant clone abundant in wastewater, carrying resistance genes blaTEM-1B, sul2, dfrA7, and tet(B), which confer resistance to ampicillin, sulfonamides, trimethoprim, and tetracycline, respectively.
Molecular epidemiology and characterization of antimicrobial-resistant Staphylococcus haemolyticus strains isolated from dairy cattle milk in Northwest, China.
The study identified several antimicrobial resistance genes in Staphylococcus haemolyticus strains isolated from dairy cattle milk in Northwest, China, including mphC, ermB, floR, aadD, sul1, and gyrA, which confer resistance to erythromycin, florfenicol, gentamicin, trimethoprim-sulfamethoxazole, and ciprofloxacin.
Clinical and Bacterial Characteristics Associated with Glove and Gown Contamination by Carbapenem-Resistant Klebsiella pneumoniae in the Health Care Setting.
The study identified various carbapenem resistance genes such as bla KPC, bla KPC-3, bla KPC-2, bla NDM, and bla OXA-232, as well as aminoglycoside resistance genes like aph(6)-Id, aph(3″)-Ib, and others. It also found sulfonamide resistance genes (sul1, sul2, sul3), beta-lactam resistance genes (bla TEM, bla OXA), and quinolone resistance genes (qnrS1).
Genomic epidemiology of nosocomial carbapenemase-producing Citrobacter freundii in sewerage systems in the Helsinki metropolitan area, Finland.
The study identified bla KPC-2 and bla VIM-1 carbapenemase genes, along with various other AMR genes such as aac(6′)-If, aph(6)-Id, aac(3)-IIa, aadA1, dfrA1, sul2, sat2, qnrB, cmlA5, bla OXA-9, bla CMY-79, bla CMY-116, bla TEM-1A, bla CMY-117, bla OXA-10, bla CFE, bla CMY-100, aac(6′)-Ib, aadA2, sul1, qnrS1, qnrB9, mph(E), msr(E), aac(6′)-Iic, and dfrA16 in carbapenemase-producing Citrobacter freundii isolates from hospital environments and municipal wastewater in Finland.
Clinically relevant antibiotic resistance in Escherichia coli from black kites in southwestern Siberia: a genetic and phenotypic investigation.
The study identified multiple antibiotic resistance genes in E. coli isolates from black kites in Siberia, including mcr-1 for colistin resistance, qnrE1 for fluoroquinolone resistance, and others such as bla TEM-1B, tet(A), sul2, and aph(3')-Ib.
A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia.
The study identifies multiple antimicrobial resistance (AMR) genes in Salmonella enterica serovar Concord, including sul1, sul2, blaCTX-M-15, qnrA1, qnrB2, and mph(A), which contribute to multidrug resistance (MDR), extensive drug resistance (XDR), and pandrug resistance (PDR).
Escherichia ruysiae May Serve as a Reservoir of Antibiotic Resistance Genes across Multiple Settings and Regions.
Analysis of pCl107 a large plasmid carried by an ST25 Acinetobacter baumannii strain reveals a complex evolutionary history and links to multiple antibiotic resistance and metabolic pathways.
The study identifies several antibiotic resistance genes in the plasmid pCl107 of an ST25 Acinetobacter baumannii strain, including aacA1, aacC2, strAB, sul2, and tetA(B), which confer resistance to aminoglycosides, sulfamethoxazole, and tetracycline.
Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Food-Producing Animals in Tamaulipas, Mexico.
The study identified ESBL-producing E. coli strains in food-producing animals in Tamaulipas, Mexico, with resistance genes including aadA1, blaCTX-M, sul2, and tetA.
Antimicrobial Susceptibility and Resistance Mechanisms in Mannheimia haemolytica Isolates from Sheep at Slaughter.
The study identified the presence of tetracycline resistance gene tetH, aminoglycoside resistance gene strA, and sulfonamide resistance gene sul2 in M. haemolytica isolates. These genes were often found in plasmid sequences but did not consistently lead to resistance phenotypes.
Evaluation of Enterotoxins and Antimicrobial Resistance in Microorganisms Isolated from Raw Sheep Milk and Cheese: Ensuring the Microbiological Safety of These Products in Southern Brazil.
The study identified several antimicrobial resistance genes, including tetM, ermB, strA, tetL, sul1, sul2, and AAC(6)', in Staphylococcus spp. isolated from raw sheep milk and cheese in southern Brazil. These genes conferred resistance to various antibiotics, highlighting the prevalence of antimicrobial resistance in these microorganisms.
Characterization of microbial community and antibiotic resistome in intra urban water, Wenzhou China.
The study identified several antimicrobial resistance genes (ARGs) in urban water samples from Wenzhou, China, including intI1, tetA, ermA, ermB, qnrB, sul1, sul2, blaSHV, and blaCTX-M. These genes were found to be associated with different bacterial species and were linked to resistance against various antibiotics such as tetracyclines, erythromycin, fluoroquinolones, sulfonamides, and beta-lactams.
Urinary Plasmids Reduce Permissivity to Coliphage Infection.
Urinary E. coli plasmids reduce permissivity to coliphage infection. Specific plasmid-encoded genes such as bla TEM-1B, aadA5, aac(6′)-Ib-cr, tet(B), sul2, dfrA17, mph(A), qacE, catB3, traT, and senB contribute to antibiotic resistance and phage resistance.
Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
The study characterizes the molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics mediated by sul genes (sul1, sul2, sul3). These genes encode sulfonamide-insensitive dihydropteroate synthase enzymes that confer broad resistance to sulfonamides.
From Farm to Fork: Persistence of Clinically Relevant Multidrug-Resistant and Copper-Tolerant Klebsiella pneumoniae Long after Colistin Withdrawal in Poultry Production.
The study identified silA and pcoD genes associated with copper tolerance in Klebsiella pneumoniae isolates from poultry, and numerous chromosomal mutations linked to colistin resistance.
Fecal antibiotic resistance genes were transferred through the distribution of soil-lettuce-snail food chain.
The study identified several antibiotic resistance genes (ARGs) such as aacA43, mel_1, vanRB, tetM, tnpA-2, sul1, sul2, ermF, and vatB that were transferred through the soil-lettuce-snail food chain. These genes conferred resistance to various antibiotics including aminoglycosides, tetracyclines, sulfonamides, MLSB, and vancomycin.
Case report: A successfully treated case of community-acquired urinary tract infection due to Klebsiella aerogenes in Bangladesh.
The study identifies several AMR genes in a multidrug-resistant Klebsiella aerogenes strain, including genes conferring resistance to aminoglycosides, beta-lactams, fluoroquinolones, and others. The strain was found to be susceptible to carbapenems and polymyxins.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
Dominance of Escherichia coli sequence types ST73, ST95, ST127 and ST131 in Australian urine isolates: a genomic analysis of antimicrobial resistance and virulence linked to F plasmids.
The study identified various antimicrobial resistance genes in E. coli isolates from Australian urine samples, including blaCTX-M-15, blaCTX-M-14, blaTEM-28, sul1, sul2, sul3, dfrA17, dfrA5, dfrA1, dfrB4, tetA, tetB, mphA, cmlA1, cmlA5, catB3, sat2, qnrD1, fosA7, aac(3)-IId, aac(3)-IIe, aph(3')-IIa, aph(6)-Id, ant(3'')-IIa, intI1, and intI2. These genes were associated with resistance to various antibiotics such as beta-lactams, sulfonamides, trimethoprim, tetracycline, macrolides, chloramphenicol, streptothricin, quinolones, fosfomycin, and aminoglycosides.
Case of Extensively Drug-Resistant Shigella sonnei Infection, United States
The study reports a case of extensively drug-resistant Shigella sonnei infection in an immunocompromised patient, highlighting the challenge of identifying XDR strains using traditional microbiological methods and emphasizing the need for whole-genome sequencing for accurate diagnosis. The isolate exhibited resistance to all first-line antimicrobials, including ciprofloxacin, azithromycin, and ceftriaxone, and carried several AMR genes such as blaCTX-M-27, qnrB19, mph(A), sul1, sul2, dfrA1, dfrA17, and tet(A).
An Insight into the Exploration of Antibiotic Resistance Genes in Calorie Restricted Diet Fed Mice.
The study found that calorie restriction increased the abundance of tetracycline resistance genes (tet W-01) and decreased the abundance of MLSB resistance genes (erm B) in mouse feces. It also identified that sul 2 was associated with sulfonamide resistance.
Genomic Characterization of Fecal Escherichia coli Isolates with Reduced Susceptibility to Beta-Lactam Antimicrobials from Wild Hogs and Coyotes.
The study identified beta-lactamase genes (blaCMY-2, blaCTX-M-55, blaCTX-M-27), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aac(3)-IId, aadA5, ant(3")-Ia, aph(3')-Ia, aph(3")-lb, aph(6)-ld), sulfonamide resistance genes (sul1, sul2, sul3), amphenicol resistance gene (floR), trimethoprim resistance genes (dfrA1, dfrA17), and MLS resistance genes (Inu(F), erm(B), mph(A)) in E. coli isolates from coyotes and wild hogs. Additionally, chromosomal mutations in ampC, gyrA, parC, and parE were found to confer resistance to beta-lactam and quinolone antibiotics.
The emergence of multi-drug resistant and virulence gene carrying Escherichia coli strains in the dairy environment: a rising threat to the environment, animal, and public health.
The study identified multidrug-resistant Escherichia coli strains carrying various antibiotic resistance genes (ARGs) and virulence-associated genes (VAGs) in the dairy environment, highlighting the potential threat to human, animal, and environmental health.
Molecular characterization of multidrug resistant Acinetobacter baumannii clinical isolates from Alexandria, Egypt.
The study identified various AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Alexandria, Egypt, including bla OXA-51-like variants, bla OXA-23, bla NDM-1, bla PER-7, bla GES-like, and others, highlighting the widespread resistance to beta-lactams, aminoglycosides, tetracyclines, and other antibiotics.
Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
The study identified various AMR genes in multidrug-resistant Gram-negative pathogens, highlighting the prevalence of bla CTX-M-15, bla CMY-42, bla NDM-5, aadA, bla TEM-1B, bla OXA-232, bla NDM-1, rmtB, rmtC, bla VEB, bla VIM-2, aph(3'), strA/B, bla OXA-23, aph (3′), catB, dfrB, bla VIM-2, fosA, oqxA, oqxB, bla OXA-23, bla CARB, bla OXA-91, bla OXA-51, bla PAO, bla SHV, aph (3′)-Ib, aph (6)-Id, mphE, msrE, ermB, mphA, aadA, rmtB, qnrB, dfrA, sul1, sul2, and fosA7.
Implications of different waterfowl farming on cephalosporin resistance: Investigating the role of bla(CTX-M-55).
The study identifies bla CTX-M-55 as a prevalent gene encoding a beta-lactamase responsible for cephalosporin resistance in E. coli isolated from waterfowl in different farming environments.
Genomic Analysis of an Escherichia coli Sequence Type 167 Isolate Harboring a Multidrug-Resistant Conjugative Plasmid, Suggesting the Potential Transmission of the Type Strains from Animals to Humans.
The study identifies multiple AMR genes in the E. coli ST167 isolate ECO3183, including bla_NDM-5, aac(6')-Ib-cr, aph(3')-Ia, aph(3")-Ib, aac(3)-IId, sul1, sul2, dfrA27, tet(A), floR, mph(A), and arr-3, which contribute to its multidrug-resistant phenotype. Additionally, a chromosomal gyrA mutation (p.S83L) was associated with fluoroquinolone resistance.
Genomic and functional portrait of multidrug-resistant, hydrogen sulfide (H(2)S)-producing variants of Escherichia coli.
The study identified multidrug-resistant, hydrogen sulfide-producing variants of Escherichia coli from Bangladesh, highlighting the presence of various AMR genes such as bla TEM1B, bla CTX-M-55, bla CTX-M-65, bla CTX-M-123, aadA1, aadA2, aph (3')-Ia, aph (3'')-Ib, aph (6)-Id, tet(A), tet(M), sul3, sul2, dfrA12, mph(A), floR, cmlA1, qacL, and qnrS1.
High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China.
The study identified a high rate of multidrug resistance in E. coli isolates from diseased ducks in China, with several AMR genes such as bla TEM, bla CTX-M, qnrS, aadA1, sul1, sul2, tet A, floR, mcr-1, intI1, and intI2 being characterized.
Comparing antimicrobial resistant genes and phenotypes across multiple sequencing platforms and assays for Enterobacterales clinical isolates.
The study compared antimicrobial resistance genes and phenotypes across different sequencing platforms and assays for Enterobacterales clinical isolates, highlighting the detection of various AMR genes such as blaKPC-2, qnrB, oqxA, oqxB, sul1, sul2, drfA*, aac(3)-IIe, and blaCTX-M-1, which conferred resistance to multiple antibiotics.
The effects of antibiotic use on the dynamics of the microbiome and resistome in pigs.
The study identified several antibiotic resistance genes (ARGs) in porcine fecal microbiota, including aacA-aphD, ermT, lnuB, strB, sul2, tetA, tetM, and blaTEM, which showed increased abundance in antibiotic-treated pigs compared to untreated pigs.
Isolation and characterization of multidrug resistant Gallibacterium anatis biovar haemolytica strains from Polish geese and hens.
The study identified 25 different antimicrobial resistance genes in multidrug-resistant Gallibacterium anatis biovar haemolytica strains from Polish geese and hens, including tetB, blaTEM-1, blaROB-1, floR, sul2, sul3, dfrK, aadA1, aadA2, aph(3)-la, aph(3)-lb, aph(6)-ld, sat2, dfrA14, dfrA32, merC, merP, merR, merT, qacL, and cmlA1.
Prevalence and molecular characterization of cefotaxime-resistant Salmonella strains recovered from retail meat samples in Shenzhen, China, during 2014-2017.
The study identified several beta-lactamase genes, including bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, bla CTX-M-130, bla CTX-M-27, and bla CMY-2, as well as other resistance genes such as qnrS1, qnrB6, mph(A), oqxAB, mcr-1.1, tet(A), tet(B), sul1, sul2, sul3, aac(6')-Ib, aph(3")-Ib, floR, drfA14, drfA1, and Inu(F), which contribute to cefotaxime resistance in Salmonella strains isolated from retail meat samples in Shenzhen, China.
Occurrence of Acinetobacter baumannii genomic resistance islands (AbGRIs) in Acinetobacter baumannii strains belonging to global clone 2 obtained from COVID-19 patients.
The study identified several AMR genes within AbGRIs in GC2 A. baumannii isolates from COVID-19 patients, including strA, strB, tetA(B), tetR(B), sul2, oxa23, aacC1, aadA1, blaTEM, armA, aacA4, aphA1b, and sul1, which confer resistance to various antibiotics such as aminoglycosides, tetracyclines, sulfonamides, carbapenems, and beta-lactams.
Genetic Diversity and Antimicrobial Resistance of Extraintestinal E. coli Populations Pre- and Post-Antimicrobial Therapy on Broilers Affected by Colisepticemia.
The study identified several AMR genes and mutations in extraintestinal E. coli populations from broilers treated with enrofloxacin. Key findings include the presence of qnrB19 and qnrS1 genes, which confer fluoroquinolone resistance, and mutations in gyrA, parC, and parE genes associated with fluoroquinolone resistance. Additionally, multiple other AMR genes were detected, indicating multidrug resistance.
Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Causing Nosocomial Meningitis in the Neurological Intensive Care Unit.
The study identified various AMR genes in 37 A. baumannii strains causing nosocomial meningitis, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, macrolide resistance genes, phenicol resistance genes, sulfonamide resistance genes, rifamycin resistance genes, and antiseptic resistance genes.
Whole Genome Sequencing and Pan-Genomic Analysis of Multidrug-Resistant Vibrio cholerae VC01 Isolated from a Clinical Sample.
The study identified multiple AMR genes in the multidrug-resistant V. cholerae VC01 strain, including catB9, floR, tet(34), sul2, and dfrA1, which confer resistance to chloramphenicol, florfenicol, oxytetracycline, sulfonamide, and trimethoprim, respectively.
Co-localization of clinically relevant antibiotic- and heavy metal resistance genes on plasmids in Klebsiella pneumoniae from marine bivalves.
The study identifies multiple antibiotic resistance genes (ARGs) and heavy metal resistance genes (HMRGs) co-localized on plasmids in Klebsiella pneumoniae isolated from marine bivalves, highlighting the potential for co-selection of these genes in the marine environment.
Plasmids conferring resistance to extended-spectrum beta-lactamases including a rare IncN+IncR multireplicon carrying bla(CTX-M-1) in Escherichia coli recovered from migrating barnacle geese ( Branta leucopsis).
The study identified several AMR genes in ESBL/AmpC-producing E. coli isolates from barnacle geese, including bla(CTX-M-1), bla(CTX-M-15), bla(CMY-2), aadA2b, lnu(F), and qnrS1, which confer resistance to various beta-lactams, aminoglycosides, lincomycin, and quinolones.
Exploring multidrug-resistant Klebsiella pneumoniae antimicrobial resistance mechanisms through whole genome sequencing analysis.
The study identified several AMR genes in MDR-Kp strains, including KPC-2, parC, rmtB, and sul2, which confer resistance to various antibiotics such as carbapenems, fluoroquinolones, aminoglycosides, and sulfonamides.
Clonal expansion and rapid characterization of Klebsiella pneumoniae ST1788, an otherwise uncommon strain spreading in Wales, UK.
The study identified several AMR genes in Klebsiella pneumoniae ST1788, including blaSHV-232, blaCTX-M-15, blaCTX-M-266, blaOXA-1, blaTEM-1, aac(3')-lla, aac(6')-lb-cr, strA, strB, qnrB1, dfrA14, sul2, and blaOXA-48. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, trimethoprim, sulfamethoxazole, and carbapenems.
Outbreak of OXA-232-producing carbapenem-resistant Klebsiella pneumoniae ST15 in a Chinese teaching hospital: a molecular epidemiological study.
The study identified the presence of multiple AMR genes, including blaOXA-232, blaCTX-M-15, blaSHV-28, fosA, oqxA, oqxB, tet(E), AAC(6')-Ib, APH(3'')-Ib, APH(6)-Id, TEM-1, sul2, QnrB17, QnrB1, dfrA14, arr-2, AAC(6')-Ib9, and rmtF, in OXA-232-producing CRKP isolates from a hospital outbreak in China.
Impact of corrosion inhibitors on antibiotic resistance, metal resistance, and microbial communities in drinking water.
Zinc orthophosphate increased antibiotic resistant bacteria (ARB) and antibiotic-resistance genes (ARGs), while sodium silicate decreased ARB and ARGs. The study identified sul1, sul2, qacEΔ1, and intI1 as key ARGs influenced by corrosion inhibitors.
Impact of corrosion inhibitors on antibiotic resistance, metal resistance, and microbial communities in drinking water.
Zinc orthophosphate increased antibiotic resistant bacteria (ARB) and antibiotic-resistance genes (ARGs), while sodium silicate decreased ARB and ARGs. The study identified sul1, sul2, qacEΔ1, and intI1 as key ARGs influenced by corrosion inhibitors.
Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.
The study identifies mcr-1.1 as a plasmid-mediated colistin resistance gene and characterizes several chromosomal mutations in mgrB, arnT, pmrA, pmrB, pmrC, phoQ, and arnB that contribute to colistin resistance in K. pneumoniae isolates from Egypt.
Co-integrate Col3m bla (NDM-1)-harboring plasmids in clinical Providencia rettgeri isolates from Argentina.
The study characterizes bla NDM-1-harboring plasmids in clinical Providencia rettgeri isolates from Argentina, highlighting the presence of various resistance genes such as bla NDM-1, aac(6')-Ib-cr5, aph(3')-Ia, aph(3')-VI, bla PER-2, qnr D1, sul1, sul2, arr3, catB3, floR, mph(E), msr(E), and tet(A).
Phenotypic and genotypic antimicrobial resistance correlation and plasmid characterization in Salmonella spp. isolates from Italy reveal high heterogeneity among serovars.
The study identified several antimicrobial resistance genes including blaTEM-1B, sul1, sul2, tetA, tetB, and others in Salmonella isolates from Italy, highlighting the diversity of resistance mechanisms among different serovars.
The origin and evolution of IncF33 plasmids based on large-scale data sets.
The study identifies several clinically important antibiotic resistance genes carried by IncF33 plasmids, including bla CTX-M-55, bla CTX-M-65, fosA3, rmtB, aph(3'')-Ib, aph(6)-Id, aph(3')-IIa, floR, oqxAB, tet(A), and sul2. These genes contribute to multidrug resistance in Enterobacterales, particularly in Escherichia coli, Salmonella, and Klebsiella pneumoniae.
Antibiotic Resistance Mediated by Escherichia coli in Kuwait Marine Environment as Revealed through Genomic Analysis.
The study identified various antibiotic resistance genes in Escherichia coli isolates from Kuwait's marine environment, including beta-lactamases, aminoglycoside-modifying enzymes, fluoroquinolone resistance genes, sulfonamide resistance genes, tetracycline resistance genes, and macrolide resistance genes. Additionally, the MFS-type drug efflux gene mdfA was commonly found in E. coli isolates.
Polyclonal Multidrug ESBL-Producing Klebsiella pneumoniae and Emergence of Susceptible Hypervirulent Klebsiella pneumoniae ST23 Isolates in Mozambique.
The study identified multiple AMR genes in Klebsiella isolates, including bla CTX-M-15, bla TEM-1, bla SHV, and bla OXA-1, which confer resistance to beta-lactams. Other genes like aac(3)-IIa, aac(6')-Ib-cr, qnrB1, qnrB6, catA1, catA2, catB3, dfrA5, dfrA7, dfrA12, dfrA14, dfrA27, sul1, sul2, mph(A), tet(A), tet(D), fosA, ARR-3, and oqxAB were also found, contributing to resistance against aminoglycosides, quinolones, chloramphenicol, trimethoprim, sulfamethoxazole, macrolides, tetracycline, fosfomycin, rifampicin, and quinolones respectively. Mutations in ompK36, ompK37, and acrR were associated with resistance to cephalosporins and fluoroquinolones, while mutations in RamR were linked to tigecycline resistance.
Comparative Genomics Reveals Novel Species and Insights into the Biotechnological Potential, Virulence, and Resistance of Alcaligenes.
The study identifies multiple antimicrobial resistance genes in Alcaligenes species, particularly in clinical isolates, highlighting the presence of genes conferring resistance to β-lactams, aminoglycosides, sulfonamides, and other antibiotics.
First Detection and Molecular Characterization of Pseudomonas aeruginosa bla(NDM-1) ST308 in Greece.
The study reports the first detection of blaNDM-1-positive Pseudomonas aeruginosa ST308 in Greece, highlighting the presence of multiple resistance genes including blaNDM-1, blaPAO, blaOXA-10, blaOXA-488, and others, indicating multidrug resistance.
Molecular characterization of highly prevalent Escherichia coli and Escherichia marmotae resistant to extended-spectrum cephalosporins in European starlings (Sturnus vulgaris) in Tunisia.
The study identified several extended-spectrum beta-lactamase (ESBL) and AmpC resistance genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, bla CMY-2, and bla CMY-62, in Escherichia coli and Escherichia marmotae isolates from European starlings in Tunisia. Additionally, aminoglycoside resistance genes such as aph(6)-Id and aph(3″)-Ib, along with fosA3, sul1, sul2, sul3, drfA1, drfA17, tet(A), and qnrS1 were also characterized.
The scope of antimicrobial resistance in residential aged care facilities determined through analysis of Escherichia coli and the total wastewater resistome.
The study identified several AMR genes in E. coli isolates from residential aged care facilities, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-62, blaOXA-1, blaOXA-181, blaTEM-1, qnrS, aac(6')-Ib-cr, sul1, sul2, and dfrA1, which confer resistance to various antibiotics such as cephalosporins, fluoroquinolones, and sulfonamides.
Genomic Analysis of Multidrug-Resistant Escherichia coli Strains Isolated in Tamaulipas, Mexico.
The study identified multiple antimicrobial resistance genes (ARGs) in multidrug-resistant E. coli strains isolated from human clinical, animal, and environmental sources in Tamaulipas, Mexico. These genes include beta-lactamases (bla CTX-M-15, bla OXA-1, bla TEM-1B, bla CMY-2), aminoglycoside resistance genes (aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aadA5, aac3-IIa), sulfonamide resistance genes (sul2, sul3), phenicol resistance gene (catB3), tetracycline resistance genes (tet(A), tet(B)), quaternary ammonium resistance genes (qacE, qacL), macrolide resistance genes (mdfA, mphA), and quinolone resistance gene (qnrB).
First Report and Characterization of the mcr-1 Positive Multidrug-Resistant Escherichia coli Strain Isolated from Pigs in Croatia.
The study reports the first mcr-1 positive multidrug-resistant E. coli strain isolated from pigs in Croatia. The strain was resistant to colistin, gentamicin, ampicillin, cefepime, cefotaxime, ceftazidime, sulfamethoxazole, chloramphenicol, nalidixic acid, and ciprofloxacin. The mcr-1 gene was located on an IncX4 plasmid, along with other resistance genes such as bla TEM-1B, bla CTX-M-1, aac(3)-IId, aph(3’)-Ia, aadA5, sul2, and catA1. Mutations in gyrA (S83L, D87N) and parC (A56T, S80I) were also identified, contributing to fluoroquinolone resistance.
The Molecular Characterization of bla(NDM-1)-Positive Acinetobacter baumannii Isolated in Central Greece.
The study identifies multiple AMR genes in blaNDM-1-positive Acinetobacter baumannii isolates, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, macrolide resistance genes, tetracycline resistance genes, trimethoprim resistance genes, and quaternary ammonium resistance genes.
Unveiling the genome of a high-risk pandrug-resistant Klebsiella pneumoniae emerging in the Brazilian Amazon Region, 2022.
The study identified a pandrug-resistant Klebsiella pneumoniae strain (Kp196) with a complex resistome comprising numerous acquired and intrinsic resistance mechanisms, including multiple beta-lactamases, aminoglycoside-modifying enzymes, quinolone resistance proteins, and mutations in genes involved in colistin, tigecycline, and fluoroquinolone resistance.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Study of heavy metal resistance genes in Escherichia coli isolates from a marine ecosystem with a history of environmental pollution (arsenic, cadmium, copper, and mercury).
The study identified several heavy metal resistance genes (HMRGs) in Escherichia coli isolates from a marine ecosystem with a history of environmental pollution, highlighting the prevalence of these genes and their potential interactions with antibiotic resistance genes.
Resistome and virulome of high-risk pandemic clones of multidrug-resistant extra-intestinal pathogenic Escherichia coli (ExPEC) isolated from tertiary healthcare settings in Uganda.
The study identified various AMR genes in multidrug-resistant E. coli isolates, including blaCTX-M-15, blaTEM-1B, blaOXA-1, and others, which confer resistance to beta-lactams, aminoglycosides, sulfonamides, tetracyclines, macrolides, and quinolones. Additionally, chromosomal mutations in gyrA and parC were found to contribute to fluoroquinolone resistance.
Genomic Diversity, Antimicrobial Resistance, Plasmidome, and Virulence Profiles of Salmonella Isolated from Small Specialty Crop Farms Revealed by Whole-Genome Sequencing.
CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic Escherichia coli.
The study identified several AMR genes carried on IncF plasmids in MDR ExPEC strains, including bla TEM-1, aac(3)-IId, tet(A), aph(6)-Id, aph(3')-Ib, mphA, sul1, sul2, aadA5, dfrA17, strAB, qacEdelta1, bla CTX-M-14, bla CTX-M-15, catB3, bla OXA-1, bla CTX-M-27, and aac(6')-Ib-cr5. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, sulfonamides, and chloramphenicol.
A One Health approach based on genomics for enhancing the Salmonella enterica surveillance in Colombia.
The study identified various AMR genes in Salmonella enterica serovars, including qnrB81, aph_6, sul2, tetA, blaCMY_2, qnrB19, aac_3_IV, blaLEN_15, aph4_la, aadA1, blaTEM_95, qnrB82, and mcr-5.1, which confer resistance to quinolones, aminoglycosides, sulfonamides, tetracyclines, beta-lactams, and colistin.
Genomic characterization of tigecycline-resistant Escherichia coli and Klebsiella pneumoniae isolates from hospital sewage.
The study identifies tet(X4) and tmexCD1-toprJ1 as key genes contributing to tigecycline resistance in E. coli and K. pneumoniae isolates from hospital sewage, highlighting the role of plasmid-mediated resistance and efflux pump overexpression.
Occurrence and temporal distribution of extended-spectrum β-lactamase-producing Escherichia coli in clams from the Central Adriatic, Italy.
The study identified several β-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV12, bla CMY-2, bla TEM-1B, bla TEM-106, and bla TEM-126, which confer resistance to various β-lactam antibiotics. Other resistance genes such as aac(6′)-Ib-cr, qnrS1, tet(A), tet(B), tet(M), aadA5, aadA2b, sul1, sul2, sul3, dfrA17, dfrA5, dfrA14, dfrA12, mph(A), cmlA1, catA2, aac(3)-IIa, aac(3)-IId, and lnu(F) were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates from clams in the Central Adriatic.
Prevalence and genomic characterization of Salmonella isolates from commercial chicken eggs retailed in traditional markets in Ghana.
The study identified several AMR genes and mutations in Salmonella isolates from chicken eggs in Ghana, including aadA1, aph(3")-Ib, aph(6)-Id, catA1, dfrA1, dfrA14, fosA7.2, qnrB19, sul1, sul2, and tet(A), as well as mutations in gyrA (D87N) and gyrA (S83Y).
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
The study identified multiple AMR genes and mutations in ESBL-producing E. coli and K. pneumoniae isolates from bulk tank milk, highlighting the presence of multidrug-resistant strains with resistance to beta-lactams, fluoroquinolones, aminoglycosides, and tetracyclines.
Genetic characterization of a multidrug-resistant Salmonella enterica serovar Agona isolated from a dietary supplement in Germany.
The study identifies 23 antibiotic resistance genes (ARGs) in a multidrug-resistant Salmonella enterica serovar Agona isolate from a dietary supplement in Germany, conferring resistance to 12 different antibiotic classes. Key genes include blaSHV-12, aac(3)-Iig, aac(6')-Iic, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, dfrA19, qacEΔ1, ere(A), sul1, sul2, tet(D), mcr-9.1, catA2, arr, qnrS1, blaTEM-1, aac(3)-IIe, and floR.
Mycobacterium ulcerans-Bordetella trematum chronic tropical cutaneous ulcer: A four-case series, Côte d'Ivoire.
Bordetella trematum isolates from chronic cutaneous ulcers in Côte d'Ivoire showed resistance to several antibiotics, including rifampicin, clarithromycin, and trimethoprim-sulfamethoxazole. A sul2 gene was identified, conferring resistance to sulfonamides.
Multiple host colonization and differential expansion of multidrug-resistant ST25-Acinetobacter baumannii clades.
The study identifies multiple AMR genes, including bla OXA-23, bla NDM-1, armA, sul2, strA, strB, tet(B), aac(6')-Ian, and aac(3)-IIa, in multidrug-resistant ST25 Acinetobacter baumannii clades, highlighting their role in resistance to various antibiotics.
Gut microbiome and antibiotic resistance effects during travelers' diarrhea treatment and prevention.
The study found that twice-daily rifaximin prophylaxis significantly increased antibiotic resistance gene (ARG) abundance in the gut microbiome, while other treatment groups showed no significant changes. Several ARGs, including blaTEM-1, mdtM, sul2, aph(6)-Id, aph(3")-Ib, erm(B), mph(A), qepA4, qnrB19, qnrS1, and arr, were identified in E. coli isolates from the TrEAT TD cohort.
Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance.
The study identified multiple antimicrobial resistance genes and mutations in Shigella isolates from Lebanon, including bla CTX-M-15 and bla CTX-M-3 for extended-spectrum beta-lactamase resistance, and gyrA mutations for quinolone resistance.
Genomic and proteomic analysis of Salmonella Enteritidis isolated from a patient with foodborne diarrhea.
The study identified multiple antimicrobial resistance genes in the Salmonella Enteritidis strain 31A, including blaTEM-194, aac(6')-Iaa, aph(3")-Ib, and sul2, which confer resistance to beta-lactam, aminoglycoside, and sulfonamide antibiotics.
Comparative genomics analysis and characterization of Shiga toxin-producing Escherichia coli O157:H7 strains reveal virulence genes, resistance genes, prophages and plasmids.
Five resistance genes were identified in E. coli O157:H7 strains, including tet(B), sul2, aph(3"-Ib), aph(6)-Id, and mdf(A).
The fate of antibiotic resistance genes during anaerobic digestion of sewage sludge with ultrasonic pretreatment.
The study investigated the effect of ultrasonic pretreatment on the fate of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) during anaerobic digestion of sewage sludge. It found that ultrasonic pretreatment significantly reduced the relative abundance of ARGs and MGEs, with 60 minutes of pretreatment achieving the highest removal rate of 41.70% for total ARGs.
Serovars, Virulence and Antimicrobial Resistance Genes of Non-Typhoidal Salmonella Strains from Dairy Systems in Mexico.
High Diversity but Monodominance of Multidrug-Resistant Bacteria in Immunocompromised Pediatric Patients with Acute Lymphoblastic Leukemia Developing GVHD Are Not Associated with Changes in Gut Mycobiome.
The study identifies multiple multidrug-resistant bacteria, including Enterococcus faecium and Klebsiella pneumoniae, carrying various resistance genes such as msr(C), erm(T), aac(6')-li, dfrG, ant(6)-la, aph(3")-Ib, sul2, and aph(6)-ld, which confer resistance to multiple antibiotics.
Shotgun Metagenomics-Guided Prediction Reveals the Metal Tolerance and Antibiotic Resistance of Microbes in Poly-Extreme Environments in the Danakil Depression, Afar Region.
The study identified numerous antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in the metagenomes of Lake Afdera and the Assale salt plain in the Danakil Depression. Key ARGs included beta-lactamases (ACC-1, OXA-58, OXA-363, OXA-212, NDM-17, OXA-134, ACT-29, LRA-19), efflux pumps (emrB, abeM, abeS, mgrA, adeJ, MexC, adeL, adeH), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet39, tetX, tetK), and others. MRGs included copper resistance genes (copC, copD), cadmium resistance gene (cadD), mercury resistance gene (merA), chromate resistance genes (chrB, chrA), nickel-cobalt-cadmium resistance genes (nccA, nccB), cobalt-zinc-cadmium resistance gene (czcD), arsenic resistance gene (arsO), lead resistance gene (pbrA), and mercury resistance genes (merB, merR, MIR).
Antimicrobial Resistant Bacteria Monitoring in Raw Seafood Retailed: a Pilot Study Focused on Vibrio and Aeromonas.
The study identified tetracycline, sulfamethoxazole, and trimethoprim/sulfamethoxazole resistance genes (tetD, tetB, tetM, tetE, sul1, sul2, and dfrA) in Vibrio and Aeromonas isolates from raw seafood samples in Japan.
Early-Onset Infection Caused by Escherichia coli Sequence Type 1193 in Late Preterm and Full-Term Neonates.
The study identifies several AMR genes in E. coli ST1193 strains causing early-onset sepsis in neonates, including blaCTX-M-15, blaOXA-1, mph(A), aac(6')-Ib-cr, dfrA17, aph(6)-Id, aac(3)-IIa, aph(3”)-Ib, sul2, catB3, sitABCD, tet(B), and blaTEM-1B, which confer resistance to various antibiotics.
Genomic characterization of Salmonella isolated from retail chicken and humans with diarrhea in Qingdao, China.
The study identified 79 antimicrobial resistance genes (ARGs) in Salmonella isolates from retail chicken and humans with diarrhea in Qingdao, China, including aac(6')-Iaa, bla TEM-1B, tet(A), aph(6)-Id, aph(3")-Ib, sul2, floR, qnrS1, bla NDM-1, mcr-1.1, and mcr-9.1. These genes conferred resistance to various antibiotics such as aminoglycosides, beta-lactams, tetracyclines, sulfonamides, chloramphenicol, fluoroquinolones, carbapenems, and colistin.
Elimination of antibiotic-resistant bacteria and resistance genes by earthworms during vermifiltration treatment of excess sludge.
The study demonstrates that earthworms significantly reduce antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in sludge through mechanisms involving coelomic fluid and gut activity, with notable reductions in tetracycline and sulfonamide resistance genes.
Genomic Insights into the Adaptation and Antibiotic Resistance Mechanisms of Williamsia chitiniclastica
The study identifies several AMR genes in Wohlfahrtiimonas chitiniclastica, including macA, macB, tehB, tet(H), tet(B), ant(2″)-Ia, aac(6′)-Ib, ant(3″)-Ib, bla VEB-1, bla OXA-1, aph(3′)-Ib, sul2, strA, and dfrA1, which confer resistance to various antibiotics such as macrolides, tetracycline, aminoglycosides, beta-lactams, sulfonamides, and trimethoprim.
Impact of systemic antimicrobial therapy on the faecal microbiome in symptomatic dairy cows.
The study identified AmpC-producing Escherichia coli strains carrying the blaCMY-2 gene, which conferred resistance to third-generation cephalosporins. Other resistance genes such as aph(6)-Id, dfrA14, and sul2 were also detected, providing resistance to streptomycin, trimethoprim, and sulfonamides, respectively.
Characteristics of antimicrobial resistance in Escherichia coli isolated from retail meat products in North Carolina.
The study identified several AMR genes in E. coli isolates from retail meat products in North Carolina, including aac(3)-IV, aadA1, aph(3'')-lb, blaTEM-1, tetB, and others, highlighting the prevalence of multidrug-resistant E. coli in ground turkey.
Metagenomic assembly is the main bottleneck in the identification of mobile genetic elements.
The study evaluated the performance of tools for identifying mobile genetic elements (MGEs) and antimicrobial resistance genes (ARGs) in metagenomic data. It found that metagenomic assembly is the main bottleneck in accurately identifying MGEs and ARGs, with moderate precision and sensitivity for plasmids, phages, IS elements, and ARGs.
Determination of antibiotic resistance patterns and genotypes of Escherichia coli isolated from wild birds.
The study identified several AMR genes in E. coli isolates from wild birds, including tet(A), tet(B), strA/strB, aphA1, sul1, sul2, and sul3, which confer resistance to tetracycline, streptomycin, kanamycin, and sulfonamides.
Persistence of Marine Bacterial Plasmid in the House Fly (Musca domestica): Marine-Derived Antimicrobial Resistance Genes Have a Chance of Invading the Human Environment.
The study shows that the marine bacterial plasmid pAQU1, carrying several antimicrobial resistance genes, can persist in the house fly intestine for up to 5 days, potentially facilitating the transmission of marine-derived antimicrobial resistance genes to the human environment.
Low temperatures do not impair the bacterial plasmid conjugation on poultry meat.
The study demonstrates that non-pathogenic E. coli can acquire an IncB/O-plasmid carrying multiple antimicrobial resistance genes through conjugation on poultry meat, even at low temperatures. This highlights the potential risk of antimicrobial resistance spread through food products.
Metagenomic identification of pathogens and antimicrobial-resistant genes in bacterial positive blood cultures by nanopore sequencing.
The study identified various antimicrobial resistance (AMR) genes in bacterial positive blood cultures using nanopore sequencing, demonstrating the effectiveness of this method in detecting resistance mechanisms and pathogens quickly.
Occurrence, genetic diversity and resistance profiles of Salmonella enterica from Brazilian sausages collected at production facilities.
The study identified Salmonella enterica isolates carrying resistance genes tet(B), strA, strB, and sul2, which confer resistance to tetracycline, streptomycin, and sulfonamide. These isolates were found in sausages from Southern Brazil, highlighting the public health concern of antimicrobial resistance in food products.
Genotypic Characterization of Uropathogenic Escherichia coli from Companion Animals: Predominance of ST372 in Dogs and Human-Related ST73 in Cats.
The study identified several AMR genes and mutations in uropathogenic E. coli isolates from companion animals, including blaTEM-1B, sul2, tet(A), qnrS1, aac(6')-Ib-c, qnrS2, qnrB19, qnrB4, CTX-M-15, CTX-M-27, CMY-2, DHA-1, blaEC, blaEC-6, and mcr-4.6. Mutations in gyrA (S83L, D87N) and parC (S80I) were also found to confer fluoroquinolone resistance.
Emergence of multidrug resistant, ctx negative seventh pandemic Vibrio cholerae O1 El Tor sequence type (ST) 69 in coastal water of Kerala, India.
The study identifies multidrug-resistant Vibrio cholerae O1 El Tor sequence type 69 in coastal waters of Kerala, India, which lacks the ctx gene but contains several antimicrobial resistance genes including sul2, dfrA1, strA, strB, parC, parE, catB9, and floR.
Plasmid content of carbapenem resistant Acinetobacter baumannii isolates belonging to five International Clones collected from hospitals of Alexandria, Egypt.
The study characterizes various AMR genes in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaPER-7, blaGES-11, blaGES-35, aph(3')-VI, aac(6')-Ib, sul1, sul2, mph(E), msr(E), armA, strA, strB, cmlA5, arr-2, ant(3'')-II, aadA1-pm, tet(B), tet(39), qacEΔ1, and dfrA7.
Characterization of nontyphoidal Salmonella strains from a tertiary hospital in China: serotype diversity, multidrug resistance, and genetic insights.
The study identified multidrug-resistant nontyphoidal Salmonella strains carrying bla CTX-M-15, qnrS1, sul1, sul2, and the mrkABCDF operon, highlighting the need for monitoring the spread of these resistance mechanisms.
Stenotrophomonas maltophilia complex: insights into evolutionary relationships, global distribution and pathogenicity.
The study identified 46 antimicrobial resistance genes (ARGs) in the Stenotrophomonas maltophilia complex (Smc), including aac(6')-Ib, ant(3'')-I, smeABC, smeRS, sul1, and sul2. These genes confer resistance to various antibiotics such as amikacin, gentamicin, ceftazidime, and trimethoprim/sulfamethoxazole. Notably, all 14 strains of S. geniculata were resistant to ceftazidime, highlighting the importance of monitoring resistance patterns in Smc species.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Genomic Characterization of a Plasmid-Free and Highly Drug-Resistant Salmonella enterica Serovar Indiana Isolate in China.
The study identifies 54 AMR genes and three AMR gene cassettes in the plasmid-free, highly drug-resistant Salmonella enterica serovar Indiana isolate S1467, contributing to resistance against multiple antimicrobial classes.
Distribution of bacterial community structures and spread of antibiotic resistome at industrially polluted sites of Mini River, Vadodara, Gujarat, India.
The study identified the presence of antibiotic resistance genes (ARGs) such as sul1, sul2, blaTEM, and aac(6')-Ib-Cr in the Mini River, highlighting the spread of antibiotic resistance in industrially polluted sites.
Genomic insights into ESBL-producing Escherichia coli isolated from non-human primates in the Peruvian Amazon.
The study identified three bla CTX-M variants (bla CTX-M-15, bla CTX-M-55, and bla CTX-M-65) and a broad resistome in ESBL-producing E. coli strains isolated from non-human primates in the Peruvian Amazon.
Clonal and plasmidic dissemination of critical antimicrobial resistance genes through clinically relevant ExPEC and APEC-like lineages (ST) in the dairy cattle population of Québec, Canada.
The study identifies the dissemination of critical AMR genes, including bla CTX-M-15, qnrS1, and bla TEM-1, in E. coli isolates from dairy cattle in Quebec, highlighting the persistence of these genes through plasmids and clones despite reduced antimicrobial use.
Klebsiella pneumoniae ST147 harboring bla(NDM-1), multidrug resistance and hypervirulence plasmids.
The study identifies the blaNDM-1 gene and various other resistance genes in multidrug-resistant Klebsiella pneumoniae ST147 strains, highlighting their role in carbapenem resistance and hypervirulence.
Whole-Genome Sequencing of an Escherichia coli ST69 Strain Harboring bla(CTX-M-27) on a Hybrid Plasmid.
The study identifies a multidrug-resistant E. coli ST69 strain carrying the bla(CTX-M-27) gene on a hybrid plasmid, along with various other antibiotic resistance genes such as aminoglycoside, macrolide, sulfonamide, tetracycline, and trimethoprim resistance genes.
Relationship between antimicrobial resistance and virulence factors in uropathogenic Escherichia coli isolates from Ramadi, Iraq: phenotype and genotype identification.
The study identified blaTEM, aac(3)-II, sul2, fimH, and hlyA as the most prevalent genes in UPEC isolates, with strong correlations between aac(3)-II and gentamicin resistance, sul2 and trimethoprim-sulfamethoxazole resistance, and fimH with antibiotic resistance.
Recommendation of a standardized broth microdilution method for antimicrobial susceptibility testing of Avibacterium paragallinarum and resistance monitoring.
The study identified several antimicrobial resistance genes in Avibacterium paragallinarum, including aph(6)-Id, aph(3'')-Ib, bla TEM-1B, catA2, sul2, tet(B), tet(H), and mcr-like, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, sulfonamides, tetracyclines, and polymyxins.
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
The study identified various antimicrobial resistance genes and mutations in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain, highlighting the presence of multidrug-resistant strains and the role of plasmids in the dissemination of resistance mechanisms.
Genomic Surveillance Uncovers a 10-Year Persistence of an OXA-24/40 Acinetobacter baumannii Clone in a Tertiary Hospital in Northern Spain.
The study identifies the persistence of an OXA-24/40 Acinetobacter baumannii clone over 10 years in a Spanish hospital, highlighting the role of the bla OXA-24/40 gene and a novel variant, bla OXA-1040, in carbapenem resistance. It also characterizes other resistance genes such as aad A1, aph (3')-VIa-like, str A, str B, sul1, sul2, and tet(B)-like, contributing to multidrug resistance.
Isolation, Identification, Antimicrobial Resistance, Genotyping, and Whole-Genome Sequencing Analysis of Salmonella Enteritidis Isolated from a Food-Poisoning Incident.
The study identified multiple antimicrobial resistance genes in Salmonella Enteritidis strain 21A, including aac(6')-Iaa, blaTEM-1, qnrB, floR, tetA, sul1, and sul2, which conferred resistance to various antibiotics such as aminoglycosides, beta-lactams, quinolones, tetracyclines, and sulfonamides.
Occurrence and molecular characteristics of antimicrobial resistance, virulence factors, and extended-spectrum β-lactamase (ESBL) producing Salmonella enterica and Escherichia coli isolated from the retail produce commodities in Bangkok, Thailand.
The study identified several AMR genes and mutations in Salmonella enterica and Escherichia coli isolated from retail produce in Bangkok, Thailand. Key findings include the presence of bla TEM, qnrS, tetA, tetB, strA, and strB genes, as well as gyrA and parC mutations associated with ciprofloxacin resistance.
Gut diversity and the resistome as biomarkers of febrile neutropenia outcome in paediatric oncology patients undergoing hematopoietic stem cell transplantation.
The study identifies several antibiotic-resistance genes associated with febrile neutropenia in pediatric oncology patients undergoing hematopoietic stem cell transplantation, including msr(C), dfrG, erm(T), VanHAX, aac(6')-Ib, aph(3')-III, ant(6)-Ia, and aac(6')-Ii.
City-scale monitoring of antibiotic resistance genes by digital PCR and metagenomics.
The study monitored the abundance and distribution of sul2 and tetW genes, which confer resistance to sulfonamide and tetracycline, respectively, in various water samples using digital PCR and metagenomics.
Antimicrobial Resistance and Molecular Characterization of Salmonella Rissen Isolated in China During 2008-2019.
The study identified multiple AMR genes in Salmonella Rissen isolates from China, including blaTEM, sul2, sul3, tetA, strA, strB, aadA, intl1VR(cx), and qacED1, which contribute to resistance against various antibiotics such as ampicillin, trimethoprim-sulfamethoxazole, tetracycline, and streptomycin.
Outbreak of NDM-5-producing Klebsiella pneumoniae ST307: an emerging high-risk antimicrobial resistance clone in Shanghai, China.
The study reports an outbreak of NDM-5-producing Klebsiella pneumoniae ST307 in Shanghai, China, highlighting the presence of multiple resistance genes including bla NDM-5, bla CTX-M-15, and bla DHA-1, which confer resistance to carbapenems, cephalosporins, and other antibiotics.
Aminoglycoside resistance genes in early members of the Acinetobacter baumannii ST78A (SMAL, Italian clone) reside in an IS26-bounded island in the chromosome.
The study identifies three aminoglycoside resistance genes (aadB, aphA1, and aac(6')-Ian) in the early ST78A isolate SMAL2002, along with sul2 and floR, located in an IS26-bounded chromosomal resistance island.
Characterization of Gallibacterium anatis Isolated from Pathological Processes in Domestic Mammals and Birds in the Czech Republic.
The study identified several AMR genes in Gallibacterium anatis isolates from calves and hens, including aph(3"-Ib, aph(6)-Id, sul2, tet(B), tet(M), bla CARB, and bla ROB. Calf isolates showed a higher incidence of AMR genes compared to hen isolates.
Multilocus sequence typing and antibiotic resistance of Aeromonas isolated from freshwater fish in Hebei Province.
The study identified several AMR genes in Aeromonas isolates from freshwater fish in Hebei Province, including TEM, tetA, floR, sul2, Ant(3")-I, and qacEΔ1, which confer resistance to various antibiotics such as penicillin, tetracycline, chloramphenicol, sulfonamide, aminoglycoside, and quinolone.
Horizontal transfer characterization of ColV plasmids in bla(CTX-M)-bearing avian Escherichia coli.
The study characterizes the horizontal transfer of ColV plasmids in bla(CTX-M)-bearing avian E. coli, identifying multiple resistance genes and virulence factors associated with these plasmids.
Activity of Epsilon-poly-L-lysine against Multidrug-Resistant Pseudomonas aeruginosa and Klebsiella pneumoniae Isolates of Urinary Tract Infections.
The study identified various beta-lactamase genes, including blaSPM, blaKPC, blaSHV, blaCTX-M, blaOXA, blaTEM, blaPER, blaVIM, and blaVIM-2 in Pseudomonas aeruginosa, and blaCTX-M, blaTEM, blaKPC, blaNDM, and blaOXA in Klebsiella pneumoniae. Additionally, aac(3)-IV, aadA1, aac(3)-II, sul2, sul1, sul3, dfrA, cmlA, and tetA were found to confer resistance to aminoglycosides, sulfonamides, trimethoprim, chloramphenicol, and tetracyclines.
Antibiotic susceptibility and resistance genes profiles of Vagococcus salmoninarum in a rainbow trout (Oncorhyncus mykiss, Walbaum) farm.
The study identified several antibiotic resistance genes in Vagococcus salmoninarum isolates from a rainbow trout farm, including tetA, sul1, sul2, sul3, dhfr1, ereB, and floR, which confer resistance to tetracycline, sulfonamides, trimethoprim/sulfamethoxazole, erythromycin, lincomycin, pristinamycin, tylosin, and florfenicol.
Genomic analysis of Salmonella isolated from canal water in Bangkok, Thailand.
The study identified 35 AMR genes and 30 chromosomal-mediated gene mutations in Salmonella strains from Bangkok canal water, highlighting the presence of multidrug-resistant strains with resistance to various antimicrobial classes.
Comparison of genotypic and phenotypic antimicrobial resistance profiles of Salmonella enterica isolates from poultry diagnostic specimens.
The study identified 31 AMR genes in 97 Salmonella enterica isolates from poultry, including aac(3)-IId, aac(3)-IVa, aac(3)-VIa, aac(6′)-Ib4, ant(2′′)-Ia, grdA, aph(3′)-Ia, aph(3′)-IIa, aadA1, aadA2, aadA7, aadA13, aph(3′)-Ib, aph(6)-Ic, aph(6)-Id, aph(4)-Ia, blaCMY-2, blaCTX-M-1, blaHER-3, blaTEM-1, floR, tetA, tetB, tetC, dfrA12, sul1, sul2, fosA7, qnrB19, ble, and mcr-9.
Global transmission of extended-spectrum cephalosporin resistance in Escherichia coli driven by epidemic plasmids.
The study identifies several epidemic plasmid subtypes carrying extended-spectrum cephalosporin resistance (ESC-R) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and bla CMY-2, which are responsible for the global dissemination of ESC-R in Escherichia coli.
Klebsiella pneumoniae sequence type 147: a high-risk clone increasingly associated with plasmids carrying both resistance and virulence elements.
The study identified various AMR genes and mutations in Klebsiella pneumoniae ST147 isolates, including bla NDM-5, bla NDM-1, bla OXA-181, bla OXA-232, bla OXA-48, aadA1, aph(3')-VI, bla CTX-M-15, bla TEM-1B/C, bla OXA-9, truncated catA1, qnrS1, sul1, dfrA5, mph(A), erm(B), aac(6')-Ib, aac(6')-Ib3, sul2, aph(3')-Ia, rmtB, fosA, oqxAB, bla SHV-11/67, arr-3, and catB3.
Predominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar.
The study identifies multidrug-resistant Salmonella Typhi genotype 4.3.1.1 with low-level ciprofloxacin resistance in Zanzibar, highlighting the presence of resistance genes blaTEM-1B, sul1, sul2, dfrA7, catA1, aph(6)-Id, and aph(3")-Ib, along with gyrA mutations D87G and S83F.
A review of the mechanisms that confer antibiotic resistance in pathotypes of E. coli.
The review discusses the mechanisms of antibiotic resistance in pathotypes of E. coli, focusing on the role of beta-lactamases, carbapenemases, and other resistance genes. It highlights the importance of understanding these mechanisms to combat the growing problem of antibiotic resistance.
Prevalence and genomic-based antimicrobial resistance analysis of Avibacterium paragallinarum isolates in Guangdong Province, China.
The study identified multiple antimicrobial resistance genes in Avibacterium paragallinarum isolates from Guangdong, China, including tet(B), aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aad-A, sul2, sul3, catP, floR, blaOXA-1, blaCTX-M-14, erm(X), mef(B), and fosA3. These genes were associated with resistance to tetracycline, streptomycin, kanamycin, trimethoprim-sulfamethoxazole, chloramphenicol, ampicillin, erythromycin, and fosfomycin.
Exploring the resistome, virulome, and mobilome of multidrug-resistant Klebsiella pneumoniae isolates: deciphering the molecular basis of carbapenem resistance.
The study identifies multiple antibiotic resistance genes, including bla CTX-M-15, bla TEM, bla SHV, bla NDM, bla OXA, and others, contributing to carbapenem resistance in Klebsiella pneumoniae isolates. Mutations in porin genes ompK35 and ompK36, as well as in gyrA and parC, are associated with reduced susceptibility to carbapenems and fluoroquinolones.
Antimicrobial Resistance Genes in Respiratory Bacteria from Weaned Dairy Heifers.
The study identified 26 AMR genes in respiratory bacteria from weaned dairy heifers, with high prevalence of tetracycline, aminoglycoside, sulfonamide, beta-lactam, phenicol, and macrolide resistance genes.
Antimicrobial susceptibility and resistome of Actinobacillus pleuropneumoniae in Taiwan: a next-generation sequencing analysis.
The study identified multiple antimicrobial resistance genes in Actinobacillus pleuropneumoniae isolates from Taiwan, including aminoglycoside, tetracycline, beta-lactam, macrolide, and phenicol resistance genes, highlighting the prevalence of multidrug resistance.
Antimicrobial susceptibility and resistome of Actinobacillus pleuropneumoniae in Taiwan: a next-generation sequencing analysis.
The study identified multiple antimicrobial resistance genes in Actinobacillus pleuropneumoniae isolates from Taiwan, including aminoglycoside, tetracycline, beta-lactam, macrolide, and phenicol resistance genes, highlighting the prevalence of multidrug resistance.
Characterization of Escherichia coli pathogenicity and drug resistance in yolk peritonitis.
The study identified multiple drug resistance genes in E. coli isolates from yolk peritonitis cases, including aadA5, APH(3")-Ib, APH(6)-Id, TEM-1, sul1, sul2, parC, gyrA, mfd, kdpE, mphA, and Mrx, which confer resistance to aminoglycosides, beta-lactams, sulfonamides, and fluoroquinolones.
Genome analyses of colistin-resistant high-risk bla(NDM-5) producing Klebsiella pneumoniae ST147 and Pseudomonas aeruginosa ST235 and ST357 in clinical settings.
The study identifies mgrB deletion and mutations in pmrB, eptA, arnT, eptB, ompA, basS, basR, arnA, cprR, and cprS as key mechanisms of colistin resistance in K. pneumoniae and P. aeruginosa.
Cryptic environmental conjugative plasmid recruits a novel hybrid transposon resulting in a new plasmid with higher dispersion potential.
The study identifies a novel hybrid transposon Tn7714 carrying multiple antibiotic resistance genes (ARGs) that was transferred from an IncF plasmid to a cryptic IncX plasmid, resulting in a new multidrug-resistant conjugative plasmid with significantly higher conjugation efficiency.
What's on a prophage: analysis of Salmonella spp. prophages identifies a diverse range of cargo with multiple virulence- and metabolism-associated functions.
The study identified several antimicrobial resistance genes (ARGs) carried by intact prophages in Salmonella spp., including acrB, mdtK, bacA, TEM-212, tet(M), and sul2, which confer resistance to various antibiotics.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
The study identifies multiple AMR genes and mutations in multidrug-resistant E. coli strains causing infections in dogs and cats, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla CMY-2, bla CMY-148, aac(6')-Ib-cr, qnrS1, qnrB6, aadA2, aadA5, aadA16, ant(3′′)-Ia, aph(3′)-Ia, aph(3′′)-Ib, aph(6)-Id, rmtB, floR, cmlA, catA, sul1, sul2, sul3, dfrA12, dfrA14, dfr17, dfrA27, tet(A), tet(B), tet(M), mph(A), erm(B), lnu(F), and arr-3, as well as the gyrA:p.S83L mutation.
Prevalence and Antimicrobial Resistance Diversity of Salmonella Isolates in Jiaxing City, China.
The study identified several AMR genes and mutations in Salmonella isolates from Jiaxing City, China, including blaTEM-1B, blaOXA-10, blaCTX-M-65, floR, sul2, qnrS1, and tet(B), as well as mutations in gyrA and parC contributing to fluoroquinolone resistance.
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications.
The study identified several AMR genes in multidrug-resistant E. coli isolates from urban environmental water sources in Accra, Ghana, highlighting the presence of beta-lactamases (blaTEM-1B, blaCTX-M-15, blaTEM-1C, blaDHA-1, blaOXA-1, blaOXA-181), sulfonamide resistance genes (sul2, sul1), aminoglycoside resistance genes (aph(6)-Id, aadA2, mph(A)), quinolone resistance gene (qnrS1), tetracycline resistance gene (tet(B)), chloramphenicol resistance gene (catA1), dihydrofolate reductase (dfrA14), and others.
Antimicrobial susceptibility profile and molecular characterization of Vibrio parahaemolyticus strains isolated from imported shrimps.
The study identified several AMR genes in V. parahaemolyticus isolates from imported shrimps, including aph(3"-Ib, aph(6)-Id, sul2, tet(59), floR, bla CARB-26, bla CARB-31, bla CARB-41, bla OXA-SHE, and qnrA5, which confer resistance to various antibiotics such as streptomycin, trimethoprim-sulfamethoxazole, tetracycline, chloramphenicol, and others.
Occurrence and genomic characterization of antimicrobial-resistant and potential pathogenic Escherichia coli from Italian artisanal food productions of animal origin.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia coli isolates from Italian artisanal food products, including beta-lactamases, aminoglycoside-modifying enzymes, trimethoprim resistance genes, macrolide resistance genes, quinolone resistance proteins, sulfonamide resistance proteins, and tetracycline resistance genes. These genes were primarily carried on plasmids and contributed to multidrug resistance.
Identification of genetic markers of resistance to macrolide class antibiotics in Mannheimia haemolytica isolates from a Saskatchewan feedlot.
The study identifies several AMR genes and a ribosomal protein mutation associated with macrolide resistance in Mannheimia haemolytica isolates from a Saskatchewan feedlot.
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
The study identified several carbapenem-resistant genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla OXA-50, bla OXA-395, bla NDM-7, and bla NDM-5, in various bacterial species in Fiji.
Genomic characterisation of Escherichia coli isolated from poultry at retail through Sink Surveillance in Dhaka, Bangladesh reveals high levels of multi-drug resistance.
The study identified multiple AMR genes in E. coli isolates from poultry in Bangladesh, including genes conferring resistance to various antibiotics such as tetracycline, ciprofloxacin, azithromycin, colistin, and others. High levels of multidrug resistance were observed, with specific genes like mcr1.1, bla CTX-M-65, and tet(A) playing significant roles.
Salmonella Typhi Haplotype 58 (H58) Biofilm Formation and Genetic Variation in Typhoid Fever Patients with Gallstones in an Endemic Setting in Kenya.
The study identified multidrug resistance genes such as sul1, dfrA7, catA1, aph(6)-Id, aph(3")-Ib, sul2, and blaTEM-1 in S. Typhi isolates from patients with gallstones. Additionally, point mutations in the quinolone resistance determining region (QRDR) of gyrA (S83Y) and gyrB (S464F) were observed, contributing to resistance against ciprofloxacin and nalidixic acid.
A panel of genotypically and phenotypically diverse clinical Acinetobacter baumannii strains for novel antibiotic development.
The study identifies various AMR genes and mutations in a diverse panel of Acinetobacter baumannii strains, including bla OXA-23, bla OXA-24, bla OXA-58, bla NDM-1, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Four novel Acinetobacter lwoffii strains isolated from the milk of cows in China with subclinical mastitis.
Four Acinetobacter lwoffii strains were isolated from the milk of cows with subclinical mastitis in China. These strains exhibited multidrug resistance and carried 17 resistance genes, including beta-lactamase, aminoglycoside-modifying, fluoroquinolone, tetracycline, sulfonamide, and chloramphenicol resistance genes.
Selection and horizontal gene transfer underlie microdiversity-level heterogeneity in resistance gene fate during wastewater treatment.
The study identifies several resistance genes, including mphA, msrE, tet(39), sul1, sul2, mer, qac, and aadA, which were found to be associated with hospital sewage and showed variations in their persistence in activated sludge. These genes contribute to resistance against macrolides, tetracyclines, sulfonamides, mercury, quaternary ammonium compounds, and aminoglycosides.
Whole-Genome Analysis of Extensively Drug-Resistant Enterobacter hormaechei Isolated from a Patient with Non-Hodgkin's Lymphoma.
The study identifies an extensively drug-resistant Enterobacter hormaechei ST90 clone carrying multiple resistance genes, including bla CTX-M-15, bla GES-2, bla TEM-1A, bla OXA-1, bla NDM-1, and bla ACT-15, along with genes encoding resistance to aminoglycosides, quinolones, sulfonamides, chloramphenicol, fosfomycin, and other antibiotics.
Metagenomic Investigation of the Short-Term Temporal and Spatial Dynamics of the Bacterial Microbiome and the Resistome Downstream of a Wastewater Treatment Plant in the Iskar River in Bulgaria.
The study identified various antimicrobial resistance genes (ARGs) in the Iskar River downstream of a wastewater treatment plant (WWTP), including genes conferring resistance to macrolides, tetracyclines, beta-lactams, sulfonamides, and carbapenems. Notably, the carbapenemase genes bla OXA-58 and bla IMP-33-like were detected, which are typically associated with clinical settings.
Genetics of resistance to trimethoprim in cotrimoxazole resistant uropathogenic Escherichia coli: integrons, transposons, and single gene cassettes.
The study identifies various dfrA gene cassettes, including dfrA1, dfrA5, dfrA7, dfrA8, and dfrA14, as the primary genetic determinants of trimethoprim resistance in cotrimoxazole-resistant uropathogenic E. coli strains. These genes are found in class 1 and 2 integrons, as well as in transposons.
Correlation analysis of whole genome sequencing of a pathogenic Escherichia coli strain of Inner Mongolian origin.
The study identified 127 antibiotic resistance genes in the E. coli strain E12, including genes for beta-lactamases, aminoglycoside modifying enzymes, sulfonamide resistance, and efflux pumps, indicating a high level of multidrug resistance.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
Pathogenomics analysis of high-risk clone ST147 multidrug-resistant Klebsiella pneumoniae isolated from a patient in Egypt.
The study identifies multiple AMR genes in the MDR-KP isolate WSF99, including various beta-lactamases, carbapenemase, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and others, highlighting the complex resistance profile of this high-risk clone.
The IncC and IncX1 resistance plasmids present in multi-drug resistant Escherichia coli strains isolated from poultry manure in Poland.
The study identifies three resistance plasmids (pECmdr13.2, pECmdr13.3, pECmdr14.1) in multi-drug resistant E. coli strains from poultry manure in Poland, each carrying various AMR genes including tetracycline, aminoglycoside, beta-lactam, sulfonamide, fluoroquinolone, and phenicol resistance genes.
A newly identified IncY plasmid from multi-drug-resistant Escherichia coli isolated from dairy cattle feces in Poland.
The study identifies two IncY plasmids from multi-drug-resistant E. coli isolated from dairy cattle feces in Poland, carrying resistance genes against beta-lactams, aminoglycosides, tetracyclines, trimethoprim/sulfamethoxazole, and fluoroquinolones.
Salmonella Typhi genotypic diversity, cluster identification and antimicrobial resistance determinants in Mukuru settlement, Nairobi Kenya.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella Typhi isolates from Mukuru settlement, Nairobi, Kenya, highlighting the prevalence of multidrug-resistant strains.
Molecular Characterization and Antibacterial Resistance Determination of Escherichia coli Isolated from Fresh Raw Mussels and Ready-to-Eat Stuffed Mussels: A Major Public Health Concern.
The study identified several AMR genes in E. coli isolates from mussels, including tetB, sul1, sul2, floR, qnrA, and qnrB, which confer resistance to tetracycline, sulfonamides, chloramphenicol, and fluoroquinolones.
Host species shapes genotype, antimicrobial resistance, and virulence profiles of enterotoxigenic Escherichia coli (ETEC) from livestock in the United States.
The study identifies distinct antimicrobial resistance (AMR) gene profiles in bovine and swine enterotoxigenic Escherichia coli (ETEC) isolates, highlighting differences in the prevalence of specific AMR genes and plasmid replicons between the two host species.
Multi-drug resistant (MDR) Gram-negative pathogenic bacteria isolated from poultry in the Noakhali region of Bangladesh.
The study identified multiple AMR genes, including blaTEM, blaSHV, tetA, tetB, sul1, sul2, and mcr-1, in various multidrug-resistant Gram-negative bacteria isolated from poultry in Bangladesh. These genes conferred resistance to a wide range of antibiotics, highlighting the significant public health concerns associated with AMR in poultry.
Phylogenetic group, antibiotic resistance, virulence gene, and genetic diversity of Escherichia coli causing bloodstream infections in Iran.
The study identified several AMR genes, including bla TEM, sul1, sul2, bla CTX-M, and bla OXA, in E. coli isolates causing bloodstream infections in Iran. These genes were associated with resistance to multiple antibiotics, highlighting the prevalence of multidrug-resistant strains.
Genomic Evaluation of Multidrug-Resistant Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli from Irrigation Water and Fresh Produce in South Africa: A Cross-Sectional Analysis.
The study identified several AMR genes in multidrug-resistant ESBL-producing E. coli isolates from irrigation water and fresh produce in South Africa, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, aph(6)-Id, ant(3″)-Ia, aadA2, aph(3″)-Ib, sul2, sul3, dfrA1, fosA3, cmlA1, and floR.
Antimicrobial resistance profiles and genome characteristics of Klebsiella isolated from the faeces of neonates in the neonatal intensive care unit.
The study identified multiple antimicrobial resistance genes in Klebsiella isolates from neonates in the NICU, including bla NDM-1, bla CTX-M-15, bla SHV-67, aac(6')-Ib-cr, aadA16, aph(3'')-Ib, and others. These genes confer resistance to various antibiotics such as carbapenems, cephalosporins, aminoglycosides, and fluoroquinolones. Additionally, the study found a multidrug-resistant Klebsiella pneumoniae strain carrying several resistance genes and plasmids.
Bacterial Genomics for National Antimicrobial Resistance Surveillance in Cambodia.
The study identified various AMR genes and mutations in bacterial isolates from Cambodia, including extended-spectrum beta-lactamase genes (blaCTX-M-15, blaCTX-M-27, blaCTX-M-55), carbapenemase genes (blaOXA-23, blaNDM-1, blaOXA-58, blaOXA-66), and colistin resistance genes (mcr-1, mcr-3, mcr-7, mcr-9). Additionally, mutations in gyrA (S83F) and parC (S84L) were found to confer fluoroquinolone resistance in Salmonella enterica serovars Paratyphi A and Typhi.
IncC plasmid genome rearrangements influence the vertical and horizontal transmission tradeoff in Escherichia coli.
The study identifies blaCTX-M-14 and blaCTX-M-15 as beta-lactamase genes, aacC2, aph, and sul2 as aminoglycoside and sulfonamide resistance genes, and shows that plasmid rearrangements enhance conjugation efficiency without affecting vertical transmission.
Carriage Rate of Enterobacterales Resistant to Extended-Spectrum Cephalosporins in the Tunisian Population.
The study identified bla CTX-M-15 and bla DHA-1 as the primary genes conferring resistance to extended-spectrum cephalosporins in Enterobacterales isolated from healthy Tunisian individuals. Additional resistance mechanisms included aminoglycoside, sulfonamide, tetracycline, and quinolone resistance genes.
Phylogenetics and Mobilization of Genomic Traits of Cephalosporin-Resistant Escherichia coli Originated from Retail Meat.
The study identified multiple AMR genes in cephalosporin-resistant E. coli from retail meat, including bla CTX-M-1, bla SHV-12, bla CMY-2, and others, highlighting the role of mobile genetic elements in the spread of resistance.
Unde venis? Bacterial resistance from environmental reservoirs to lettuce: tracking microbiome and resistome over a growth period.
The study identified multidrug and β-lactam antibiotic resistance genes (ARGs) in lettuce and water, while lettuce and soil uniquely shared mainly glycopeptide and tetracycline ARGs. Manure was found to be the main source of resistance markers on young lettuce plants.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
High Carriage of tetA, sul1, sul2 and bla (TEM) Resistance Genes among the Multidrug-resistant Uropathogenic Escherichia coli (UPEC) Strains from Malaysian Patients.
The study identified the high prevalence of tetA, sul1, sul2, and bla TEM resistance genes among multidrug-resistant Uropathogenic Escherichia coli (UPEC) strains in Malaysia.
Biofilm enhanced the mitigations of antibiotics and resistome in sulfadiazine and trimethoprim co-contaminated soils.
The study identifies several AMR genes, including aadA7, aac(6')-II, aac(3)-iid, aadD, tetA, tetM, tetX, and sul2, in Arthrobacter sp. D2, which are involved in resistance to aminoglycosides, tetracyclines, and sulfonamides. These genes were experimentally validated using high-throughput qPCR analysis.
Antibiotic Resistance Genes and Plasmid Characteristics in Enterobacteriaceae Isolated from Fresh Produce
The study identified several antibiotic resistance genes on plasmids and chromosomes of Enterobacteriaceae strains isolated from fresh produce, highlighting the diversity of resistance mechanisms and the potential for horizontal gene transfer.
Extended-spectrum beta-lactamase (ESBL)- and non-ESBL producing Escherichia coli surveillance in surface water sources in Edo State, Nigeria: a public health concern.
The study identified ESBL genes bla TEM, bla CTX-M-1, and bla CTX-M-15, as well as resistance genes tetM, sul1, sul2, and qnrA in ESBL and non-ESBL-producing E. coli isolates from surface water in Edo State, Nigeria.
Genomic Characteristics of a Carbapenem-Resistant Klebsiella pneumoniae Co-Carrying bla (NDM-5) and bla (KPC-2) Capsular Type KL25 Recovered from a County Level Hospital in China.
The study reports the genomic characteristics of a multidrug-resistant ST11 Klebsiella pneumoniae isolate SM117 with capsular serotype KL25, co-carrying bla NDM-5, two copies of bla KPC-2, and multiple plasmid-borne virulence genes. The isolate shows resistance to all antibiotics except polymyxin.
Whole-genome sequencing of two multidrug-resistant acinetobacter baumannii strains isolated from a neonatal intensive care unit in Egypt: a prospective cross-sectional study.
The study identified multidrug-resistant Acinetobacter baumannii strains from a neonatal ICU in Egypt, highlighting the presence of various beta-lactamase genes, aminoglycoside resistance genes, macrolide resistance genes, tetracycline resistance genes, and sulfonamide resistance genes.
Genomic Characterization of Extended-Spectrum β-Lactamase-Producing and Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from Stools of Primary Healthcare Patients in Ethiopia.
The study identified multiple antimicrobial resistance genes in E. coli isolates, including bla CTX-M-15, bla TEM-1B, tet(A), qnrS1, and others, highlighting the prevalence of multidrug resistance in the region.
Genome-Based Analysis of Genetic Diversity, Antimicrobial Susceptibility, and Virulence Gene Distribution in Salmonella Pullorum Isolates from Poultry in China.
The study identified several AMR genes and mutations in Salmonella Pullorum isolates from China, including aac(6')-Iaa, aadA5, blaTEM1β, sul2, tet(A), and qacE, as well as gyrA mutations (S83F, S84F, D87N), which are associated with resistance to streptomycin, ampicillin, ciprofloxacin, sulfamethoxazole, tetracycline, and disinfectants.
Comprehensive Genomic Analysis of Uropathogenic E. coli: Virulence Factors, Antimicrobial Resistance, and Mobile Genetic Elements.
The study identified numerous antimicrobial resistance genes and mutations in uropathogenic E. coli isolates, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and quinolone resistance genes. Mutations in gyrA, parC, parE, and marR were associated with fluoroquinolone resistance, while mutations in PmrB, CyaA, GlpT, PtsI, and UhpT were linked to fosfomycin resistance.
Investigation on the mechanisms of carbapenem resistance among the non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae.
The study identified non-carbapenemase β-lactamase genes and chromosomal mutations, including missense mutation or loss of ompK36 porin and frameshift missense mutation in efflux pump systems, as potential mechanisms of carbapenem resistance in NC-CRKP.
Environmental contamination with carbapenem resistant Acinetobacter baumannii in healthcare settings in Fiji: a potential source of infection.
The study identified several carbapenem-resistant Acinetobacter baumannii (CR Ab) isolates from high-touch surfaces in Fijian hospitals, revealing the presence of resistance genes such as bla OXA-23, bla NDM-1, and others, along with mutations in genes like parC and gyrA, contributing to resistance against multiple antibiotics.
Metagenomic assemblies tend to break around antibiotic resistance genes.
The study evaluates the performance of various metagenomic assemblers in capturing antibiotic resistance genes (ARGs) and their genomic contexts, highlighting challenges in accurately reconstructing ARGs from short-read data.
Surveillance of travel-associated isolates elucidates the diversity of non-pandemic Vibrio cholerae.
The study identified various AMR genes in travel-associated V. cholerae isolates, including catB9, floR, sul2, and tetA, which confer resistance to chloramphenicol, sulfonamide, and tetracycline. These genes were detected in both 7PET and non-7PET lineages.
Analyzing Antibiotic Resistance in Bacteria from Wastewater in Pakistan Using Whole-Genome Sequencing.
The study identifies several AMR genes and mutations in wastewater isolates from Pakistan, highlighting the presence of carbapenemases like blaNDM-5 and blaOXA-1, as well as quinolone resistance determinants such as gyrA and parC mutations. These findings emphasize the role of wastewater as a reservoir for clinically relevant AMR genes.
Determinants of Antibiotic Resistance and Virulence Factors in the Genome of Escherichia coli APEC 36 Strain Isolated from a Broiler Chicken with Generalized Colibacillosis.
The study identifies multiple antibiotic resistance genes in the E. coli APEC 36 strain, including beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and efflux pumps, indicating a high level of multidrug resistance.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Genomic characterization of a clonal emergent Salmonella Minnesota lineage in Brazil reveals the presence of a novel megaplasmid of resistance and virulence.
The study identifies multidrug resistance genes such as bla CMY-2, sul2, tet (A), and qnrB19 in a clonal emergent Salmonella Minnesota lineage in Brazil, along with a novel megaplasmid pESM carrying resistance and virulence factors.
Analysis of Acinetobacter P-type type IV secretion system-encoding plasmid diversity uncovers extensive secretion system conservation and diverse antibiotic resistance determinants.
This study identified 17 distinct antibiotic resistance genes across 53 P-type T4SS-encoding plasmids in Acinetobacter species, including various beta-lactamases, aminoglycoside modifying enzymes, and others, highlighting the significant diversity of resistance determinants carried by these plasmids.
Combatting extensively drug-resistant Salmonella: a global perspective on outbreaks, impacts, and control strategies.
The paper discusses the emergence and global spread of extensively drug-resistant (XDR) Salmonella, highlighting the resistance mechanisms involving genes such as blaCTX-M-15, floR, cat1, cat2, strA, strB, aacC(3), aadA, ant(3")-Ia, aph(3)-IIa, tet(A), tet(B), tet(D), tet(G), tet(H), dfrA10, dhfrXII, sul1, sul2, sul3, mphA, and ermB.
Extended-spectrum beta-lactamase-producing Enterobacterales in human health: Experience from the tricycle project, Ghana.
The study identified a high prevalence of ESBL-E carriage among pregnant women in Ghana, with blaCTX-M-15 being the most prevalent ESBL gene. The study also found that 50% of ESBL-E isolates were multidrug resistant, highlighting the urgent need for public health interventions to control the spread of AMR.
A nosocomial outbreak of colistin and carbapenem-resistant hypervirulent Klebsiella pneumoniae in a large teaching hospital.
Neural network-based predictions of antimicrobial resistance phenotypes in multidrug-resistant Acinetobacter baumannii from whole genome sequencing and gene expression.
The study presents a deep neural network model capable of predicting antimicrobial resistance phenotypes in multidrug-resistant Acinetobacter baumannii using whole genome sequencing and gene expression data. The model achieves high accuracy in predicting resistance to various antibiotics, including β-lactams, aminoglycosides, and carbapenems.
Effects of sulfamethoxazole and copper on the natural microbial community from a fertilized soil.
The study identified the presence of sul1 and sul2 genes in the soil microbial community, which confer resistance to sulfamethoxazole. The presence of copper was found to increase the persistence of these resistance genes.
Genomic characterisation of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate assigned to a novel sequence type (6914).
The study reports the genomic characterization of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate, Cow102, which exhibits multidrug resistance. It identifies several resistance genes, including blaSHV-1, blaSHV-11, blaSHV-13, blaSHV-26, blaSHV-70, blaSHV-78, blaSHV-98, blaSHV-145, blaTEM-1B, aadA2, catA2, catII, dfrA16, fosA, oqxA, oqxB, sul1, sul2, and tet(D).
Survey in ruminants from Rwanda revealed high diversity and prevalence of extended-spectrum cephalosporin-resistant Enterobacterales.
The study identified various extended-spectrum cephalosporin-resistant Enterobacterales in ruminants from Rwanda, including multiple beta-lactamase genes such as bla CTX-M-15, bla TEM-1, and others, along with non-beta-lactam resistance genes like tet(A), sul2, and qnrS1.
Genome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
The study identified various AMR genes in Shigella isolates from Fujian Province, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CTX-M-64), macrolide resistance genes (mphA, ermB), tetracycline resistance genes (tetA, tetB), aminoglycoside resistance genes (aadA, aph(3')-Ib, aac(3)-IId), chloramphenicol resistance gene (catA1), and sulfonamide/trimethoprim resistance genes (sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA17).
Increased Severity of Multidrug-Resistant Shigella sonnei Infections in People Experiencing Homelessness.
The study identifies a clonal expansion of multidrug-resistant Shigella sonnei (genotype 3.6.1.1.2) with resistance to multiple antibiotics, including ampicillin, trimethoprim-sulfamethoxazole, ciprofloxacin, and azithromycin.
Genomic surveillance detects interregional spread of New Delhi metallo-beta-lactamase-1-producing Providencia stuartii in hospitals, Romania, December 2021 to September 2023.
The study identifies the spread of NDM-1-producing Providencia stuartii in Romania, highlighting the presence of multiple resistance genes including bla NDM-1, bla OXA-10, bla CMY-4, bla CMY-16, bla CMY-194, qnrD2, armA, aph(3')-VI, aac(6')-Ib3, rmtC, dfrA14, dfrA12, sul1, and sul2.
Escherichia coli from six European countries reveals differences in profile and distribution of critical antimicrobial resistance determinants within One Health compartments, 2013 to 2020.
The study identified various AMR genes in E. coli isolates from different sources in six European countries, highlighting differences in resistance profiles and the prevalence of specific resistance mechanisms such as beta-lactamases, quinolone resistance genes, and tetracycline resistance genes.
Florfenicol administration in piglets co-selects for multiple antimicrobial resistance genes.
Florfenicol administration in piglets leads to the selection of multiple antimicrobial resistance genes, including those conferring resistance to phenicols, aminoglycosides, beta-lactams, sulfonamides, and oxazolidinones.
Comparative genomics analysis of Salmonella Enteritidis isolated from clinical cases associated with chicken.
Five Salmonella Enteritidis isolates were analyzed, revealing multiple antimicrobial resistance genes and chromosomal mutations. Key resistance genes included bla CTX−M−55, bla TEM−141, bla TEM−1B, aac(6')-Iaa, aph(3’)-IIa, aph(3’’)-Ib, aph(6)-Id, tet(A), floR, fosA3, and sul2. Chromosomal mutations in gyrA (D87G/D87Y) and acrB (F28L/L40P) were also identified, contributing to fluoroquinolone and multidrug resistance.
Antimicrobial resistance, virulence factors and phylogenetic profiles of Vibrio parahaemolyticus in the eastern coast of Shenzhen.
The study identified several antimicrobial resistance genes in Vibrio parahaemolyticus isolates from Shenzhen, including blaCARB, tet(34), tet(35), qnrVC6, sul2, aph(6)-Id, floR, cat, and blaCTX-M-14. These genes conferred resistance to various antibiotics such as ampicillin, tetracycline, fluoroquinolones, sulfonamides, aminoglycosides, chloramphenicol, and beta-lactams.
Multidrug-resistant ESBL-producing Klebsiella pneumoniae complex in Czech hospitals, wastewaters and surface waters.
The study identified multidrug-resistant Klebsiella pneumoniae complex isolates carrying various beta-lactamase genes such as bla CTX-M-15, bla GES-51, bla OXA-48, bla NDM-1, and bla KPC-3, along with other resistance genes like oqxA, oqxB, sul2, aph(6)-Id, dfr14, qnrB1, and aac(6')-Ib-cr.
Data-Driven Approaches in Antimicrobial Resistance: Machine Learning Solutions.
This study uses unsupervised machine learning to identify patterns in AMR genes, linking gene length and resistance class to resistance mechanisms. Key AMR genes identified include sul1, sul2, cat, blaTEM, vanA, aac(6')-Ib, aph(3')-IIIa, tet(M), and tet(O).
Salmonella Typhi Haplotype 58 biofilm formation and genetic variation in isolates from typhoid fever patients with gallstones in an endemic setting in Kenya.
The study identified multidrug resistance genes sul1, dfrA7, catA1, aph(6)-Id, aph(3" )-Ib, sul2, and blaTEM-1 in S. Typhi isolates from household D, along with specific mutations in the quinolone resistance-determining region (QRDR) of gyrA and gyrB. Additionally, missense mutations in the treB and tviE genes were observed in isolates from different households.
Two outbreak cases involving ST65-KL2 and ST11-KL64 hypervirulent carbapenem-resistant Klebsiella pneumoniae: similarity and diversity analysis.
The study identifies two outbreak cases of hypervirulent carbapenem-resistant Klebsiella pneumoniae (hvCRKP) strains, ST65-KL2 and ST11-KL64, highlighting their distinct resistance mechanisms and virulence profiles.
Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307.
The study identifies the colistin resistance gene mcr-8.1 in multidrug-resistant Klebsiella pneumoniae ST307 isolates from Armenia, highlighting the emergence of this gene in the region.
Characterizing Methicillin-Resistant Staphylococcus spp. and Extended-Spectrum Cephalosporin-Resistant Escherichia coli in Cattle.
The study identified several AMR genes in E. coli and MRSA isolates from cattle in Austria, including bla CTX-M-1/15, bla CTX-M-9, bla TEM, tet (A), tet (B), dfrA1, dfrA5, dfrA14, dfrA17, sul2, sul3, aadA1, aadA2, floR, cmlA, aphA, and bla ACT. Additionally, the MRSA isolate carried the mecA gene, indicating methicillin resistance.
Fecal carriage of ESBL-producing E. coli and genetic characterization in rural children and livestock in the Somali region, Ethiopia: a one health approach.
The study identified bla CTX-M-15 as the most prevalent ESBL gene in both human and animal E. coli isolates, along with other resistance genes such as bla TEM-1B, bla OXA-1, and various aminoglycoside, sulfonamide, and trimethoprim resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Phenotypic and genotypic characterization of clinical carbapenem-resistant Acinetobacter species harboring the metallo-beta-lactamases IMP-8 or NDM-1 in China.
The study characterized the phenotypic and genotypic features of one IMP-8-producing and four NDM-1-producing plasmids in Acinetobacter spp. strains isolated in 2010, highlighting the presence of various resistance genes including blaIMP-8, blaNDM-1, aac(6')-Ib, aac(3)-IId, msr(E), mph(E), sul1, sul2, tet(39), and aph(3')-VI.
Epidemiology and Molecular Characterisation of Multidrug-Resistant Escherichia coli Isolated from Cow Milk.
The study identified several AMR genes in multidrug-resistant E. coli isolates from cow milk, including bla TEM, bla CTX-M, bla OXA-1, bla OXA-2, bla CMY-1, tet A, tet B, tet D, sul -1, and sul -2, which confer resistance to various antibiotics.
Molecular Epidemiology and Genetic Characterization of Carbapenem-Resistant Acinetobacter baumannii Isolates from the ICU of a Tertiary Hospital in East China.
The study identified 48 antimicrobial resistance genes (ARGs) in 39 carbapenem-resistant Acinetobacter baumannii (CRAB) isolates, including blaOXA-66, blaOXA-23, blaADC-30, blaADC-73, gyrA, ant(3")-IIa, aph(3")-Ib, aph(6)-Id, tetB, tetR, sul1, sul2, LpsB, LpxC, and LpxA, which confer resistance to various antibiotics such as carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, tetracycline, and sulfonamides.
Tracking Multidrug Resistance in Gram-Negative Bacteria in Alexandria, Egypt (2020-2023): An Integrated Analysis of Patient Data and Diagnostic Tools.
The study identified bla NDM-5 as the most prevalent carbapenemase gene in E. coli isolates from Alexandria, Egypt, along with other resistance genes such as bla OXA-48, bla VIM, bla CTX-M-15, aadA2, aac(6')-Ib, qnrS1, dfrA12, sul1, and sul2.
Genome-based development and clinical evaluation of a customized LAMP panel to rapidly detect, quantify, and determine antibiotic sensitivity of Escherichia coli in native urine samples from urological patients.
The study developed a LAMP panel to detect and determine antibiotic sensitivity of E. coli in urine samples, focusing on resistance genes such as blaTEM1-β, blaCTX-M-14, blaCTX-M-15, sul2, dfrA17, and hlyA.
Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic Escherichia coli and Staphylococcus aureus Strains?
The study identified several antibiotic resistance genes in clinical strains of Staphylococcus aureus and Escherichia coli, including blaZ, grlA, grlB, gyrA, mecA, ermC, aph(6)-Id, aph(3")-Ib, aadA5, blaCTX-M-27, mph(A), sul1, sul2, tet(A), and dfrA17. These genes confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, aminoglycosides, sulfonamides, tetracyclines, and macrolides.
Prevalence and genomic insights of carbapenem resistant and ESBL producing Multidrug resistant Escherichia coli in urinary tract infections.
The study identified multiple AMR genes, including NDM-5, CTX-M-15, TEM-1, and others, in carbapenem-resistant and ESBL-producing multidrug-resistant E. coli isolates from urinary tract infections.
Multidrug-resistant ST11-KL64 hypervirulent Klebsiella pneumoniae with multiple bla- genes isolated from children's blood.
An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids.
Pandemic one health clones of Escherichia coli and Klebsiella pneumoniae producing CTX-M-14, CTX-M-27, CTX-M-55 and CTX-M-65 ESβLs among companion animals in northern Ecuador.
The study identifies CTX-M-55, CTX-M-65, CTX-M-27, and CTX-M-14 ESβL-producing E. coli and K. pneumoniae in companion animals in Ecuador, highlighting their global One Health significance and the need for surveillance programs.
Highly drug resistant clone of Salmonella Kentucky ST198 in clinical infections and poultry in Zimbabwe.
The study identifies multiple AMR genes and mutations in Salmonella Kentucky ST198 strains from Zimbabwe, highlighting their multidrug resistance and the presence of specific resistance mechanisms such as blaCTX-M-14.1 and mutations in gyrA and parC.
Phenotypic and genotypic characterization of antimicrobial resistance and virulence profiles of Salmonella enterica serotypes isolated from necropsied horses in Kentucky.
The study identified several AMR genes in Salmonella enterica isolates from necropsied horses, including beta-lactamase genes (blaTEM, blaCTX-M, blaSHV2, blaOXA-9), aminoglycoside resistance gene (aacA[3]), sulfonamide resistance gene (sul2), amphenicol resistance gene (floR), tetracycline resistance gene (tetB), streptomycin resistance gene (strA), macrolide resistance gene (ermB2), and quinolone resistance gene (qnrB2). These genes were associated with resistance to multiple antibiotics, highlighting the presence of multidrug-resistant Salmonella strains.
Clonal Spread and Genetic Mechanisms Underpinning Ciprofloxacin Resistance in Salmonella enteritidis.
The study identified multiple plasmid-mediated quinolone resistance (PMQR) genes, including aac(6')-Ib-cr, qnrA, qnrS, and oqxAB, as well as GyrA mutations (S83Y, D87Y, S83Y-D87Y, S83R, D87N, D87G) in ciprofloxacin-resistant Salmonella enteritidis isolates. These genes and mutations were found to contribute to ciprofloxacin resistance through various mechanisms, including efflux pump overexpression and enzymatic modification of antibiotics.
Assessment of Antibiotic Resistance Among Isolates of Klebsiella spp. and Raoultella spp. in Wildlife and Their Environment from Portugal: A Positive Epidemiologic Outcome.
The study identified a single multidrug-resistant (MDR) and extended-spectrum beta-lactamase (ESBL)-producing K. pneumoniae isolate from soil samples carrying multiple resistance genes, including bla CTX-M-15, bla TEM-1, bla SHV-28, bla OXA-1, qnr B1, oqx A, oqx B19, aac (6′)-Ibcr, sul 2, dfr A14, tet A, aph (6)-Id, aph (3″)-Ib, acr D, cat B3, and Int I1.
Genetic analysis reveals the genetic diversity and zoonotic potential of Streptococcus dysgalactiae isolates from sheep.
The study identified tet(M), tet(O), and erm(B) as the primary AMR genes in S. dysgalactiae isolates from sheep, contributing to resistance against doxycycline and erythromycin.
Cockroaches as Reservoirs, Vectors, and Potential Sentinels of Multidrug-Resistant Bacteria in Ugandan Communities: A Retrospective Analysis.
The study identified tetracycline and sulfonamide resistance genes (tetA, sul1, sul2) in Escherichia coli and tetracycline resistance genes (tetM, tetL) in Enterococcus spp. from cockroaches in Ugandan communities.
Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from retail markets in Yichun city, China, including genes conferring resistance to various antibiotics such as chloramphenicol, tetracycline, trimethoprim, and extended-spectrum beta-lactamases.
Whole-genome sequencing of Acinetobacter baumannii clinical isolates from a tertiary hospital in Terengganu, Malaysia (2011-2020), revealed the predominance of the Global Clone 2 lineage.
The study identified the predominance of the Global Clone 2 lineage of Acinetobacter baumannii in Terengganu, Malaysia, with a focus on the detection of various antimicrobial resistance genes, including bla OXA-23, bla ADC, bla NDM-1, and others, contributing to multidrug resistance.
Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease.
The study identified several clinically relevant antimicrobial resistance genes (ARGs) in bovine respiratory disease (BRD) pathogens, including estT, floR, mphE, erm(42), msrE, aadA, ANT(2''-Ia), APH(3''-Ib), APH(3'-Ia), APH(6)-Id, sul2, tet(H), ROB-1, and OXA-2. Additionally, mutations in gyrA and parC were found to confer resistance to fluoroquinolones in Mannheimia haemolytica.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Tracing the evolution: the rise of Salmonella Thompson co-resistant to clinically important antibiotics in China, 1997-2020.
The study identifies the IncC plasmid as a major driver of co-resistance to ciprofloxacin, cefotaxime, and azithromycin in Salmonella Thompson isolates in China, with specific resistance genes including qnrS1, qepA4, blaCMY-2, and mph(A).
Abundance of clinically relevant antimicrobial resistance genes in the golden jackal (Canis aureus) gut.
The study identified a high prevalence of clinically relevant antimicrobial resistance genes in golden jackals, including beta-lactamases (bla TEM-1, bla CTX-M-15, bla SHV), quinolone resistance (qnrS), and class 1 integrons (Int1).
Genomic epidemiology and antimicrobial resistance of Morganella clinical isolates between 2016 and 2023.
The study identified several AMR genes in Morganella clinical isolates, including tet(B), sul1, catA2, sul2, floR, aadA1, and others, contributing to resistance against various antibiotics.
Phenotypic and genetic heterogeneity of Acinetobacter baumannii in the course of an animal chronic infection.
The study identified a conserved colistin resistance due to a pmrB mutation in Acinetobacter baumannii isolates during a 5-year urinary tract infection in an animal patient, despite the absence of antibiotic treatment.
Circulation of a Unique Klebsiella pneumoniae Clone, ST147 NDM-1/OXA-48, in Two Diverse Hospitals in Calabria (Italy).
The study identifies multiple AMR genes, including bla OXA-48, bla NDM-1, bla CTX-M-15, and bla SHV, in K. pneumoniae strains from two hospitals in Calabria, Italy, highlighting the presence of multidrug-resistant clones.
Epidemic trend of Salmonella from swines and broilers in China from 2014 to 2023 and genetic evolution analysis of ESBLs-producing strains.
The study identified several AMR genes in ESBL-producing Salmonella strains from swines and broilers in China, including blaCTX-M-14, blaTEM-1B, blaCTX-M-65, aac(6')-Iaa, floR, sul2, tet(B), arr-2, fosA3, dfrA12, mph(A), lnu(F), blaCTX-M-55, blaOXA-1, sul1, tet(A), catB3, qnrS1, and mcr-1.1. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, sulfonamides, tetracyclines, rifampicin, fosfomycin, trimethoprim, macrolides, lincomycin, quinolones, and colistin.
Wastewater based genomic surveillance key to population level monitoring of AmpC/ESBL producing Escherichia coli.
The study identified various AMR genes and mutations in AmpC/ESBL-producing E. coli from wastewater samples in Finland, highlighting the prevalence of blaCTX-M-15, blaCTX-M-27, and other resistance determinants.
Avian-specific Salmonella transition to endemicity is accompanied by localized resistome and mobilome interaction.
The study identifies several antimicrobial resistance genes, including bla TEM-1B, sul2, and tet(A), which are prevalent in Salmonella enterica serovar Gallinarum isolates. These genes contribute to the resistome diversity and are associated with specific lineages and geographical regions.
Fecal carriage and molecular characterization of carbapenem-resistant Enterobacteriaceae from hospitalized children in a tertiary hospital of Shandong, China.
The study identified bla NDM-1, bla NDM-5, and bla OXA-1 as the most prevalent carbapenemase genes in CRE isolates from hospitalized children in Shandong, China. Additional resistance genes such as bla CTX-M-55, bla CTX-M-15, sul 1, tet A, and mcr-1.26 were also characterized.
Molecular epidemiology of a multidrug-resistant Shigella sonnei outbreak in Tunisia (2022-2023) using whole-genome sequencing.
The study identifies multiple AMR genes and mutations in a multidrug-resistant Shigella sonnei outbreak in Tunisia, including blaCTX-M-15, dfrA1, qnrS1, sul2, tet(A), mph(A), and blaTEM-35, along with the D87Y mutation in gyrA.
Microplastics enhance the prevalence of antibiotic resistance genes in mariculture sediments by enriching host bacteria and promoting horizontal gene transfer.
Microplastics enhance the prevalence of antibiotic resistance genes in mariculture sediments by enriching host bacteria and promoting horizontal gene transfer.
Detection of a genetically related carbapenemase-producing Escherichia coli ST167 in clinical and environmental isolates: Evidence for clonal spread of carbapenemase-producing Enterobacteriaceae in humans and the environment in Iowa, United States.
The study identifies a carbapenemase-producing E. coli strain BO1 carrying bla NDM-5, along with other resistance genes, highlighting the clonal spread of carbapenemase-producing Enterobacteriaceae between humans and the environment in Iowa.
Integrative and conjugative elements associated with antimicrobial resistance in multidrug resistant Pasteurella multocida isolates from bovine respiratory disease (BRD)-affected animals in Spanish feedlots.
The study identified multiple antimicrobial resistance genes and mutations in multidrug-resistant Pasteurella multocida isolates from bovine respiratory disease-affected animals in Spanish feedlots, highlighting the role of mobile genetic elements in the spread of resistance.
Carbapenem-Resistant, Virulence Plasmid-Harboring Klebsiella pneumoniae, United States.
The study identifies six pVir-CRKP isolates from the United States, highlighting their multidrug resistance and enhanced virulence traits. These isolates exhibit resistance to various antibiotics, including carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, due to the presence of specific AMR genes and mutations.
Broiler litter moisture and trace metals contribute to the persistence of Salmonella strains that harbor large plasmids carrying siderophores.
The study identified several antimicrobial resistance genes in Salmonella strains isolated from broiler litter, including aadA1, aac(3)-IV, aph(3′)-Ia, aph(4)-Ia, dfrA14, floR, sul1, tetA, sul2, merRTPCA, qacE, aph(3″)-Ib, aph(6)-Id, pcoABCDRE, silP, and silE. These genes were found on various plasmids and contributed to resistance against multiple antibiotics such as streptomycin, chloramphenicol, sulfamethoxazole, tetracycline, mercury, quaternary ammonium compounds, copper, and silver.
Genomic insights into extended-spectrum β-lactamase- and plasmid-borne AmpC-producing Escherichia coli transmission between humans and livestock in rural Cambodia.
The study identifies a wide range of AMR genes, including bla CTX-M, bla TEM, tet(A), sul2, aph(3'')-Ib, aac(6')-Ib-cr, qnrS1, lnu(F), mph(A), and mcr-1.1, in ESC-Ec strains from humans and livestock in rural Cambodia, highlighting the transmission of these genes between hosts.
Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from blood cultures.
The study presents a rapid whole-genome sequencing workflow (LC-WGS) for diagnosing bloodstream infections, demonstrating accurate identification of bacterial pathogens and detection of clinically relevant resistance markers within 4.2 hours. The workflow successfully identified various AMR genes, including bla CTX-M-15, bla DHA-1, bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-23, armA, mecA, vanRSHAXYZ, aac(6')-Ie/aph(2'')-Ia, aph(3')-IIIa, aac(6')-I, sul1, and dfrA17.
Whole-Genome Sequencing of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Isolated from Human Bloodstream Infections.
The study identified multiple AMR genes in ESBL-producing K. pneumoniae isolates, including blaCTX-M-15, blaKPC-3, and others conferring resistance to β-lactams, aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and chloramphenicol.
Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals.
The study identified several antimicrobial resistance genes in uropathogenic E. coli strains from companion animals, including blaTEM-1b, sul1, sul2, dfrA1_10, dfrA17_1, dfrA1_8, dfrA7_5, gyrA_S83L, tetA, tetB, aph(6)-Id, aph(3'')-Ib, ant(3'')-Ia, blaCTX-M-15, blaTEM-106, blaSHV-102, and blaCMY-2. These genes confer resistance to various antibiotics such as penicillins, sulfonamides, trimethoprim, quinolones, tetracyclines, streptomycin, and cephalosporins.
Polyclonal carbapenemase-producing Escherichia coli in Northern Italy: the emergence of NDM-7.
The study identifies the emergence of NDM-7 in polyclonal carbapenemase-producing E. coli in Northern Italy, highlighting the presence of various carbapenemase genes such as bla KPC-3, bla VIM-1, and bla NDM-7, along with other resistance genes.
Comprehensive genomic epidemiology and antimicrobial resistance profiles of clinical Klebsiella pneumoniae species complex isolates from a tertiary hospital in Wenzhou, China (2019-2021).
The study identified a variety of antimicrobial resistance genes in clinical Klebsiella pneumoniae species complex isolates, including bla KPC−2, bla CTX−M, bla SHV, aac(6')-Ib, aadA1, aadA2, aph(3')-Ia, oqxAB, qnrB19, qnrS1, tet(A), tet(D), sul1, sul2, sul3, cmlA1, floR, fosA, and fosA3. These genes confer resistance to multiple classes of antibiotics, highlighting the complexity of antimicrobial resistance in these isolates.
Comprehensive molecular epidemiology of Acinetobacter baumannii from diverse sources in Nigeria.
The study identified 168 AMR genes in 189 Nigerian A. baumannii isolates, including blaADC-79, blaOXA-23, aph(3")-Ib, and others, highlighting the widespread presence of multidrug resistance.
High prevalence of plasmid-mediated Fosfomycin resistance in waterfowl-derived Escherichia coli strains: insights into genetic context and transmission dynamics in China.
The study identifies fosA3 as a prevalent plasmid-mediated fosfomycin resistance gene in waterfowl-derived E. coli strains, along with other resistance genes such as blaCTX-M-55, blaNDM-5, mcr-1.1, tetA, floR, qnrS, sul2, and aphA1. These genes contribute to multidrug resistance and highlight the importance of monitoring their spread.
Whole-genome-based characterization of Escherichia albertii strains isolated from paediatric diarrhoeal cases in Kolkata, India.
The study identified several antimicrobial resistance genes in Escherichia albertii isolates, including beta-lactamases (bla CTX-M-55, bla TEM-105), quinolone resistance genes (qnrS1, qnrB32), sulfonamide resistance gene (sul2), tetracycline resistance genes (tetA, tetR), and trimethoprim resistance gene (dfrA1).
Antimicrobial Resistance in Livestock and Its Impact on Public Health
The study highlights the role of livestock environments as reservoirs for antimicrobial resistance genes, identifying blaCTX-M-1, tetA, qnrS, and sul2 as key contributors to resistance in Escherichia coli, Salmonella spp., and Staphylococcus spp.
Recent emergence of cephalosporin-resistant Salmonella Typhi in India due to the endemic clone acquiring IncFIB(K) plasmid encoding bla (CTX-M-15) gene.
The study identifies the emergence of a new clone of ceftriaxone-resistant Salmonella Typhi in India, which acquired an IncFIB(K) plasmid encoding the bla(CTX-M-15) gene, along with other resistance determinants such as qnrS1, sul2, dfrA14, tet(A), aph(3"), and aph(6').
Genomic characterization of extended-spectrum β-lactamase-producing Escherichia coli spread among chickens and healthy residents in Lombok, Indonesia.
The study identifies bla CTX-M-55, bla CTX-M-15, bla CTX-M-1, bla CMY-2, and bla DHA-1 as the most prevalent extended-spectrum β-lactamase genes in E. coli isolates from chickens and humans in Lombok, Indonesia. Additionally, the study characterizes a 200 kb IncHI1 plasmid carrying multiple resistance genes, including aac(3)-IId, aph(6)-Id, aph(3’’)-Ib, aadA17, mph(A), Inu(F), qnrS1, sul2, and dfrA14, contributing to multidrug resistance.
Phenotypic and Genomic Assessment of Antimicrobial Resistance and Virulence Factors Determinants in Salmonella Heidelberg Isolated from Broiler Chickens.
The study identified high levels of antimicrobial resistance in Salmonella Heidelberg strains from broiler chickens in Brazil, with resistance genes tet(A), sul2, fosA7, and aac(6')-Iaa, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Antimicrobial susceptibility trends of S. Typhi and S. Paratyphi in a post-COVID-19 pandemic India, from a multicenter surveillance network.
The study identified several antimicrobial resistance genes including blaCTX-M-15, qnrS1, sul2, dfrA14, and tet(A) in ceftriaxone-resistant S. Typhi isolates. A S83F mutation in gyrA was associated with reduced susceptibility to ciprofloxacin.
Potential pathogens drive ARGs enrichment during biofilms formation on environmental surfaces.
The study identifies several antibiotic resistance genes (ARGs) such as sul1, sul2, ermF, and intI-1 that are enriched in biofilms on environmental surfaces, highlighting the role of potential pathogens in ARG dissemination.
Isolation, Antimicrobial Susceptibility, and Genotypes of Three Pasteurellaeae Species Prevalent on Pig Farms in China Between 2021 and 2023.
The study identified 18 antimicrobial resistance genes in three Pasteurellaeae species, including tetracycline, beta-lactam, sulfonamide, aminoglycoside, and macrolide resistance genes. High frequencies of tet(L), tet(M), tet(A), blaTEM, sul2, aph(3')-Ia, dfrA12, qnrS1, strA, sul3, and mef(B) were observed.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Genome-Based Molecular Diversity of Extended-Spectrum β-Lactamase-Producing Escherichia coli From Pigeons in China.
The study identifies multiple extended-spectrum β-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla OXA, bla LAP, and bla CMY, as well as other antibiotic resistance genes such as mcr-1, mcr-1.1, tet(X4), aadA1, aadA2, aph(6)-Id, aph(3")-Ib, aph(3')-Ia, aph(3')-IIa, aac(3)-IVa, aph(4)-Ia, tet(A), tet(M), sul2, sul3, dfrA14, qnrS1, arr-2, fosA3, cmlA5, floR, mph(A), and lnu(F) in ESBL-producing E. coli isolates from pigeons in China.
Wild Birds as Drivers of Salmonella Braenderup and Multidrug Resistant Bacteria in Wetlands of Northern Italy.
The study identifies several AMR genes in bacterial isolates from wild aquatic birds in Northern Italy, including beta-lactamases (blaTEM, blaCMY-1, blaCMY-2, blaNDM, blaKPC), colistin resistance genes (mcr-2, mcr-3, mcr-4), tetracycline resistance genes (tetA, tetB, tetC, tetL, tetM, tetK), macrolide resistance genes (ermB, vatD, vgA, msrC), vancomycin resistance genes (vanC1, vanC2, vanM, vanG), sulfonamide resistance genes (sul1, sul2, sul3), aminoglycoside resistance genes (aac(3), aac(6')-Ib, aph(3')-Ia, armA, rmtB, rmtC, rmtF), and nitrofurantoin resistance genes (nfsA, nfsB).
Occurrence and characterization of Salmonella isolates from commercial eggs in Phayao Province, Thailand.
The study identified Salmonella contamination in eggshells from three different production systems, with one isolate showing resistance to sulfamethoxazole/trimethoprim due to the presence of sul1 and sul2 genes.
AmrProfiler: A Comprehensive Tool for Antimicrobial Resistance Gene Detection and Analysis
AmrProfiler identifies a wide range of AMR genes and mutations across multiple bacterial species, demonstrating high accuracy and broader species coverage compared to existing tools.
Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.
The First Case of Antimicrobial-Resistant Salmonella Stanley ST29 Diagnosed Secondary to Acute Cholecystitis.
The study identifies multiple antimicrobial resistance genes in Salmonella Stanley ST29, including beta-lactamases, quinolone resistance genes, macrolide resistance genes, and others, contributing to resistance against various antibiotics.
Epidemiology and molecular characterisation of multidrug-resistant Escherichia coli isolated from chicken meat.
The study identified bla TEM and sul 2 genes as key contributors to ampicillin and sulfamethoxazole-trimethoprim resistance in multidrug-resistant E. coli isolates from chicken meat.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
Molecular characterization of multidrug-resistant E. coli recovered from diarrheagenic children under 5 years from Mukuru Informal Settlement, Nairobi, Kenya, based on whole-genome sequencing analysis.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from diarrheagenic children in Nairobi, Kenya, highlighting the presence of blaTEM-1B, blaCTX-M-15, qnrS1, qnrB4, aac(6')-Ib-cr, and other resistance mechanisms.
Rapid whole genome sequencing for AMR surveillance in low- and middle-income countries: Oxford Nanopore Technology reveals multidrug-resistant Enterobacter cloacae complex from dairy farms in Sri Lanka.
The study identified multiple AMR genes in multidrug-resistant Enterobacter isolates from dairy farms in Sri Lanka, including blaCMH-1, blaACT-25, blaCTX-M-15, blaOXA-1, blaTEM-1, blaNDM-4, and blaNDM-15, highlighting the presence of carbapenem-resistant Enterobacterales and the need for improved AMR surveillance in low-resource settings.
Multidrug-resistant Shigella flexneri outbreak affecting humans and non-human primates in New Mexico, USA.
The study identifies multidrug-resistant Shigella flexneri serotype 2a strains in both human and non-human primate populations in New Mexico, USA, carrying resistance genes such as blaOXA-1, blaTEM-1, sul2, dfrA1, and dfrA5, along with fluoroquinolone resistance-conferring mutations in parC and gyrA.
Comparative genomics of Salmonella enterica serovars Paratyphi A, Typhi and Typhimurium reveals distinct profiles of their pangenome, mobile genetic elements, antimicrobial resistance and defense systems repertoire.
The study compares the pangenome, mobile genetic elements, antimicrobial resistance, and defense systems of Salmonella enterica serovars Paratyphi A, Typhi, and Typhimurium, revealing distinct profiles in their genomic structures and resistance mechanisms.
Antimicrobial resistance and genetic diversity of Escherichia coli isolated from marine bivalves.
The study identified several AMR genes in E. coli isolates from marine bivalves, including bla TEM, bla CTX-M9, bla SHV, bla CTX-M2, bla CTX-M8/25, qnrS, qnrB, sul1, and sul2. These genes were associated with resistance to various antibiotics, highlighting the role of marine environments in the dissemination of AMR.
The pet café is a neglected site for transmission of antimicrobial-resistant Escherichia coli in urban life.
The study identifies multiple antimicrobial resistance genes (ARGs) in Escherichia coli isolates from pet cafés, highlighting the role of plasmids in the transmission of these genes. Key ARGs include tet(X4), sul2, sul3, strA, strB, dfrA14, qnrS1, qnrS2, oqxB, blaCTX-M-15, blaCTX-M-14, blaCTX-M-65, floR, and tet(A).
Molecular characterization of multidrug-resistant Escherichia coli in the Greater Accra Region, Ghana: a 'One Health' approach.
The study identified multidrug-resistant Escherichia coli isolates carrying various AMR genes, including blaTEM-1B, tetA, sul2, aph(3'')-Id, dfrA14, qnrS1, and blaCTX-M-15, highlighting the spread of resistance mechanisms in the Greater Accra Region.
Comprehensive analysis of extensive drug-resistant Salmonella Typhi in Gujarat region, India: genomic findings and prospective alternative therapy.
The study identified multiple AMR genes and mutations in extensive drug-resistant Salmonella Typhi isolates from Gujarat, India, including aph(3'')-Ib, aph(6)-Id, bla CTX-M, dfrA14, qnrS1, sul2, tet(A), mdtK, and gyrA mutations, contributing to resistance against various antibiotics such as tetracycline, fluoroquinolones, and beta-lactams.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
The study identified multiple antibiotic resistance genes and mutations in E. coli isolates from intensive pig farming in South Africa, highlighting the spread of resistance across the pork production continuum.
Clonal dissemination and persistence of Carbapenem-resistant bla (KPC-2) harbouring Klebsiella pneumoniae ST307 in a Tertiary Hospital in the Republic of Korea.
Prevalence and molecular characterisation of multi-drug resistant ST11 hypervirulent Klebsiella pneumoniae in a teaching hospital.
The study identifies several AMR genes in CRKP strains, including bla KPC-2, bla NDM-1, bla VIM, bla SHV-12, bla TEM-1b, aac(6')-Ib-cr, qnrS, qnrB, rmtB, ant(3'')-I, armA, sul1, sul2, iucA, iutA, iroN, ybtS, mrkD, fimH, and p rmpA. These genes confer resistance to carbapenems, quinolones, aminoglycosides, and sulfonamides. Additionally, the study highlights the transferability of these genes through conjugation.
Integrated genomic-epigenomic-transcriptomic analyses reveal adaptive mechanisms of colistin and carbapenem resistance in Klebsiella pneumoniae and Enterobacter isolates
The study identifies multiple AMR genes and mutations associated with colistin and carbapenem resistance in Klebsiella pneumoniae and Enterobacter isolates, including beta-lactamases, fosfomycin resistance genes, and efflux pumps. Mutations in ompK35 were found to contribute to carbapenem resistance.
Local Genomic Epidemiology of Acinetobacter baumannii Circulating in Hospital and Non-hospital Environments in Kano, Northwest Nigeria.
The study identifies various AMR genes in Acinetobacter baumannii isolates from hospital and non-hospital environments in Kano, Nigeria, including bla OXA-66, bla OXA-180, bla ADC-25, aadA1, aph(3')-Ia, aph(3'' )-Ib, aac(3)-Ia, aph(6)-Id, tetB, sul1, and sul2, which confer resistance to beta-lactams, aminoglycosides, tetracyclines, and sulfonamides.
Genomic insights into antibiotic-resistant non-typhoidal Salmonella isolates from outpatients in Minhang District in Shanghai.
The study identifies multiple antibiotic resistance genes and mutations in non-typhoidal Salmonella isolates from Minhang District, Shanghai, highlighting the prevalence of multidrug-resistant strains and the role of specific genetic elements in resistance mechanisms.
Genomic and machine learning approaches to predict antimicrobial resistance in Stenotrophomonas maltophilia.
The study identifies key genetic markers associated with resistance to levofloxacin (LEV) and trimethoprim-sulfamethoxazole (SXT) in Stenotrophomonas maltophilia, including mutations in parC, gyrA, and smeT, as well as the presence of sul1, sul2, Gsh2, and gspD genes.
Occurrence and Drivers of Antibiotic Resistance Genes Carried by Bacteriophages in Soils Following Different Fertilization Treatments.
The study identified 19 pARG subtypes in soils with different fertilization treatments, highlighting the impact of organic fertilizers on the diversity and abundance of antibiotic resistance genes carried by bacteriophages.
Characterizing antimicrobial resistance and plasmidome diversity in Escherichia coli from imported frozen broiler chicken in the United Arab Emirates.
The study identified several AMR genes in E. coli isolates from imported frozen broiler chicken in the UAE, including bla CTX-M-55, bla CTX-M-8, bla TEM-1B, aadA1, qnrS1, tetA, sul1, sul2, and sul3. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, and sulfonamides.
Multidrug-resistant Klebsiella pneumoniae ST70 harboring bla(NDM) in a migratory Penguin.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Klebsiella pneumoniae ST70 isolate from a Magellanic Penguin, highlighting the potential of migratory penguins as vectors of antimicrobial-resistant microorganisms.
Variants of β-lactamase-encoding genes are disseminated by multiple genetically distinct lineages of bloodstream Escherichia coli.
The study identified multiple β-lactamase genes, including bla TEM-1, bla CTX-M-15, and bla OXA-1, along with other AMR genes such as aadA5, aph(3")-Ib, aph(6)-Id, mphA, sul1, sul2, tetA, dfrA17, and aac(6')-Ib-cr5, which confer resistance to various antimicrobial classes in bloodstream E. coli isolates.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica.
The study identified several AMR genes in E. coli isolates from two sloth species in Costa Rica, including blaTEM-1B, aph(3')-Id, aph(6)-Id, tet(A), tet(B), sul2, qnrS1, floR, and dfrA8, which were associated with resistance to various antibiotics.
Genomic features of three major diarrhoeagenic Escherichia coli pathotypes in India.
The study identifies a variety of acquired antimicrobial resistance (AMR) genes in diarrhoeagenic Escherichia coli (DEC) strains from India, highlighting the prevalence of resistance to multiple antibiotic classes, including aminoglycosides, beta-lactams, sulfonamides, and tetracyclines. Key AMR genes include blaTEM-105, strB, strA, mphA, sul1, sul2, addA1-pm, tetA, tetB, blaCTX-M15, blaCTX-M27, and blaDHA-1. Additionally, mutations in the quinolone resistance-determining regions (QRDRs) of gyrA and parC were found to contribute to fluoroquinolone resistance.
Genomic epidemiology reveals antibiotic resistance transfer and polyclonal dissemination of Acinetobacter baumannii in a Paraguayan hospital.
The study identifies multiple antibiotic resistance genes, including blaOXA-23, ADC-344, ADC-345, blaTEM-1, Sul1, Sul2, and TetB, in Acinetobacter baumannii isolates from a Paraguayan hospital, highlighting the presence of multidrug-resistant strains and horizontal gene transfer of resistance mechanisms.
Diversity versus clonality in carbapenem-resistant A. baumannii: a two-year surveillance study in four intensive care units at a large teaching hospital in Rome, Italy.
The study identified carbapenem-resistant Acinetobacter baumannii isolates carrying the blaOXA-23 gene and aminoglycoside resistance genes such as armA, aadA2, aph(3')-VIa, and ant(2")-Ia. Other resistance genes included mph(E), msr(E), sul1, sul2, and tet(B).
Taxonomic and phenotypic characterization of a novel Providencia species: Providencia lanzhouensis sp. nov.
The study identifies Providencia lanzhouensis sp. nov., a novel species with multiple antimicrobial resistance genes, including aadA1, aadA2, aph(6)-Id, aph(3'')-Ib, aph(3')-Ia, sat2, sul2, ere(A), dfrA32, floR, tetC, and qnrD1, which confer resistance to aminoglycosides, streptomycin, sulfonamides, macrolides, trimethoprim, phenicols, tetracyclines, and quinolones.
Antimicrobial resistance and biofilm formation in rarely reported Salmonella enterica serovars from patients presenting with gastroenteritis in Nairobi, Kenya.
Three Salmonella Newport isolates carried acquired antimicrobial resistance genes, including bla TEM −1 , tet(A), aph(6)-Id, dfrA14, and sul2. These genes conferred resistance to ampicillin, tetracycline, trimethoprim-sulfamethoxazole, and gentamicin.
Plasmid diversity in Klebsiella pneumoniae ST307 co-producing KPC plus NDM recovered during the COVID-19 pandemic.
The study characterizes the plasmid diversity in Klebsiella pneumoniae ST307 isolates co-producing KPC and NDM carbapenemases, identifying multiple resistance genes and plasmid types involved in carbapenem resistance.
A strain defined as a novel species in the Acinetobacter genus co-harboring chromosomal associated tet(X3) and plasmid associated bla (NDM-1) from a beef cattle farm in Hebei, China.
The study identifies a novel Acinetobacter species co-harboring chromosomal tet(X3) and plasmid-associated bla(NDM-1) genes, demonstrating resistance to multiple antibiotics including carbapenems and tetracyclines.
Phylogenomics, evolution and origin of multidrug-resistant Acinetobacter baumannii ST15.
The study identifies multiple carbapenem resistance genes, including blaOXA-23, blaOXA-51, blaOXA-219, blaOXA-58, blaOXA-253, and blaOXA-72, as well as other resistance genes such as aphA6 and sul2, in multidrug-resistant Acinetobacter baumannii ST15 strains.
Overlooked Enterobacterales as hosts of antimicrobial resistance in aquatic environments.
The study identified several AMR genes in environmental Enterobacterales isolates, including blaTEM-1, blaCTX-M, tetA, tetB, tetC, tetL, tetM, sul1, sul2, qnrS, ermB, and mefA, which conferred resistance to various antibiotics such as ampicillin, ceftazidime, cefepime, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and erythromycin.
Clonal spread of bla(CTX-M-65) producing Salmonella enterica serovars detected in poultry retail meat in North Carolina, USA.
The study identifies the clonal spread of bla(CTX-M-65) producing Salmonella enterica serovars in poultry retail meat in North Carolina, USA. It characterizes the resistance profiles of these isolates, including the presence of bla(CTX-M-65), aac(3)-Iva, aadA1, aph(4)-Ia, floR, mdsA, mdsB, sul1, tet(A), dfrA14, aph(3')-Ia, sul2, aph(3'')-Ib, and fosA3.
Genomic Characterization and Antibiotic Resistance Profiles of Acinetobacter baumannii Isolates From Intensive Care Units in Vietnam.
The study identifies multiple AMR genes in three CRAB isolates, including blaOXA-23, blaOXA-66, blaADC-198, blaADC-73, and various aminoglycoside modifying enzymes, efflux pumps, and sulfonamide resistance genes, highlighting the extensive multidrug resistance in these isolates.
Emergence of carbapenem-resistant Acinetobacter baumannii clonal complex 2 in multiple hospitals in São Paulo state, Brazil.
The study identifies the emergence of carbapenem-resistant Acinetobacter baumannii clonal complex 2 (CC2) in multiple hospitals in São Paulo, Brazil, with resistance genes including blaOXA-23, armA, aadB, aphA1, aphA6, sul1, sul2, and tetB.
Biofilm Formation and Antibiotic Resistance Genes of Escherichia coli From Poultry Farms and Clinical Samples.
The study identified several AMR genes in E. coli isolates from poultry and clinical samples, including blaTEM, gyrA, gyrB, qnrB, qnrB4, qnrS, blaCTX-M, sul1, sul2, tetA, and tetB. These genes conferred resistance to various antibiotics such as beta-lactams, fluoroquinolones, sulfonamides, and tetracyclines. High levels of resistance were observed against tylosin, neomycin, tetracycline, ampicillin, doxycycline, ciprofloxacin, and trimethoprim/sulfamethoxazole.
TRENDS IN MULTIPLE ANTIBIOTIC RESISTANCE AMONG PREDOMINANT HOSPITAL ISOLATES: ANNUAL VARIATIONS AND PEAK SEASONAL PATTERNS
The study identified mecA, vanA, and tetM as key resistance genes in Staphylococcus aureus isolates with high multiple antibiotic resistance indices, indicating the presence of methicillin-resistant and vancomycin-resistant strains.
Genomic insights into bacteriophages: a new frontier in AMR detection and phage therapy.
The paper discusses the identification of various AMR genes in Acinetobacter baumannii and other pathogens, highlighting their role in resistance to multiple antibiotics and the potential of phage therapy as an alternative treatment.
Population Structure, Genomic Features, and Antibiotic Resistance of Avian Pathogenic Escherichia coli in Shandong Province and Adjacent Regions, China (2008-2023).
The study identified multiple antibiotic resistance genes and mutations in Avian Pathogenic Escherichia coli (APEC) isolates from Shandong Province and adjacent regions in China, highlighting the high prevalence of multidrug resistance and the presence of specific resistance mechanisms such as beta-lactamases, tetracycline resistance genes, and fluoroquinolone resistance mutations.
Genomic characterization of an ESBL-producing Klebsiella pneumoniae ST37 recovered from a hospitalized patient in Armenia.
The study identified several AMR genes in the ESBL-producing K. pneumoniae ST37 isolate ARM02, including blaTEM-1D, blaSHV-11, dfrA14, sul2, strA, strB, and blaCTX-M-15, which were directly linked to the observed resistance phenotypes.
Epidemiological and biological characteristics of IncR plasmids as multihost antibiotic resistance carriers.
The study characterizes various AMR genes carried by IncR plasmids, highlighting their role in the dissemination of resistance to carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, and tetracyclines.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
The study identified 50 acquired resistance genes and seven chromosomal-mediated gene mutations in Salmonella populations from Thai canal water, highlighting the prevalence of multidrug-resistant strains and the diversity of resistance mechanisms.
Analyzing Shigella in Wuhan: Serotypes, Antimicrobial Resistance, and Public Health Implications.
The study identified multiple AMR genes and mutations in Shigella flexneri isolates from Wuhan, including blaCTX-M, blaOXA, blaTEM, dfrA1, sul2, tetB, aadA1, and qnrS, along with specific mutations in gyrA, parC, and parE that confer resistance to various antibiotics.
The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital.
The study identified several AMR genes and mutations in colistin-resistant P. aeruginosa isolates, including blaNDM-1, blaOXA-1028, blaOXA-904, and mutations in phoQ and basR genes associated with colistin resistance.
Epidemiology of potential source, risk attribution of Clostridium perfringens from Egyptian broiler farms and genetic diversity of multidrug resistance strains.
The study identified multiple AMR genes in Clostridium perfringens isolates from Egyptian broiler farms, including aminoglycoside, beta-lactam, macrolide, quinolone, sulfonamide, tetracycline, and trimethoprim resistance genes. High prevalence of multidrug-resistant strains was observed.
Epidemiology of potential source, risk attribution of Clostridium perfringens from Egyptian broiler farms and genetic diversity of multidrug resistance strains.
The study identified multiple AMR genes in Clostridium perfringens isolates from Egyptian broiler farms, including aminoglycoside, beta-lactam, macrolide, quinolone, sulfonamide, tetracycline, and trimethoprim resistance genes. High prevalence of multidrug-resistant strains was observed.
Plasmid-driven clonal expansion of multidrug-resistant monophasic Salmonella Typhimurium in a Global Food Trade Hub.
The study identifies several AMR genes and mutations in multidrug-resistant Salmonella 1,4,[5],12:i:-, including aac(6')-Iaa, tet(B), blaTEM-1B, blaOXA-1, qnrS1, mcr-1.1, blaCTX-M-14, blaCTX-M-55, blaNDM-5, and sul2, which contribute to resistance against various antibiotics.
Genomic profiling of cefotaxime-resistant Haemophilus influenzae from Norway and Sweden reveals extensive expansion of virulent multidrug-resistant international clones.
The study identifies the expansion of multidrug-resistant Haemophilus influenzae clones with cefotaxime resistance, primarily due to mutations in the ftsI gene encoding penicillin-binding protein 3 (PBP3). These mutations lead to cross-resistance to multiple beta-lactam antibiotics.
Tracking Enterobacteria, microbiomes, and antibiotic resistance genes from waste to soil with repeated compost applications.
The study identifies several AMR genes including bla CTX-M, bla TEM-1B, bla SHV-12, qnr A, qnr B, aac(6')-Ib, sul 1, sul 2, intI 1, and intI 2 in Enterobacteria from composts and raw waste, highlighting their persistence and potential spread in tropical soils.
Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria.
The study characterizes several AMR genes, including blaIPM-4, blaOXA-1, blaOXA-10, aacA4, blaOXA-101, aadA11, aadA9, qacEΔ1, sat2-aadA1, and others, highlighting their role in conferring resistance to various antibiotics in different bacterial species.
Genomic characterization of multidrug-resistant clinical Acinetobacter baumannii isolates from a hospital in Paraguay.
The study identified multiple AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Paraguay, including blaOXA-23, blaOXA-66, blaOXA-65, blaADC-73, blaADC-5, blaTEM-1, and various aminoglycoside, macrolide, sulfonamide, chloramphenicol, tetracycline, and trimethoprim resistance genes.
Cefiderocol-resistant pathogens in German hospital wastewater: a reservoir for multidrug resistance.
The study identifies multiple AMR genes, including bla NDM−1, bla VIM−1, bla OXA−48, and bla KPC−2, in cefiderocol-resistant isolates from German hospital wastewater, highlighting the presence of multidrug-resistant pathogens with diverse resistance mechanisms.
Clonal Dissemination of Pandrug-Resistant Klebsiella pneumoniae ST392KL27 in a Tertiary Care Hospital in Mexico.
Outbreak Caused by VIM-1- and VIM-4-Positive Proteus mirabilis in a Hospital in Zagreb.
The study reports an outbreak of carbapenem-resistant Proteus mirabilis in a psychiatric hospital in Zagreb, Croatia, characterized by the presence of VIM-1 and VIM-4 carbapenemases, along with other resistance genes such as bla CTX-M-15, bla TEM, and aminoglycoside resistance genes.
Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics.
The study identified genomic resistance elements in historical clinical isolates, showing that resistance to antibiotics existed before their clinical introduction and increased in frequency and mobility after the age of antibiotics.
Molecular and phenotypic characteristics of isolated Escherichia coli from the skin, gills, and intestine of rainbow trout in retail stores of Kerman, Iran.
The study identified several AMR genes in E. coli isolates from rainbow trout, including blaTEM, qnrA, tetB, sul1, and sul2, which confer resistance to beta-lactams, fluoroquinolones, tetracyclines, and sulfonamides.
Towards the integration of antibiotic resistance gene mobility into environmental surveillance and risk assessment.
The study highlights the importance of incorporating antibiotic resistance gene (ARG) mobility into environmental surveillance and risk assessment. It identifies specific ARGs such as bla OXA, bla KPC-2, bla TEM-1, bla GES-2, bla GES-5, sul 1, and sul 2 as highly mobile and potentially risky in various environmental settings.
Evidence of ESBL plasmid transfer and selective persistence of multiple host-associated Escherichia coli isolates in a chicken cecal fermentation model.
The study identifies multiple ESBL-producing E. coli isolates and characterizes their resistance genes, highlighting the transfer of bla CTX-M-1 plasmids among isolates in a chicken cecal fermentation model.
Global phylogeography and genomic characterization of bla(NDM-1)-positive clinical Proteus mirabilis isolates from China.
The study identifies blaNDM-1 as a key determinant of carbapenem resistance in Proteus mirabilis isolates from China, along with other resistance genes such as blaCTX-M-14, blaCTX-M-65, and blaTEM-1. It also characterizes the genomic context of blaNDM-1, including its integration into SGI1 and plasmid-borne elements.
Heterogeneous Salmonella typhi transmission within a household: genomic insights from a chronic carrier.
The study characterizes AMR genes and mutations in Salmonella Typhi isolates from a household cluster, highlighting the presence of blaTEM-1, aac(6)-Iy, aph(6)-Id, dfrA-7, sul-1, sul-2, and catA-1, along with fluoroquinolone resistance mutations in gyrA and parC.
Molecular Characteristics of Epidemiologically Successful Salmonella Enteritidis in Poland.
The study identified several AMR genes and mutations in Salmonella Enteritidis strains, including qnrB19, blaTEM-1, blaTEM-135, tet(A), sul2, and mutations in gyrA (S83Y, D87Y, S83F, S464Y).
Antibiotic resistance and novel Sequence Types of Klebsiella spp. in human, animal, and food sources: a One Health perspective from Northern Nigeria.
The study identified various AMR genes in Klebsiella spp. isolates from human, animal, and food sources, including strB, qnrS1, sul2, tetA, dfrA14, blaTEM-1, and blaSHV-11, which conferred resistance to multiple antibiotics.
Dissemination dynamics of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones.
The study characterizes the dissemination of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones in Enterobacter species, highlighting their co-occurrence with other resistance genes and their global distribution.
Whole-Genome Sequencing Uncovers Chromosomal and Plasmid-Borne Multidrug Resistance and Virulence Genes in Poultry-Associated Escherichia coli from Nigeria.
The study identified multiple antimicrobial resistance genes in a multidrug-resistant E. coli strain from poultry in Nigeria, including blaCTX-M-15, blaOXA-1, blaTEM-1, aac(6')-Ib-cr, aadA5, aph(3'')-Ib, sul1, sul2, tet(A), mph(A), and dfrA17, highlighting the role of plasmids in the spread of resistance.
Comparative Analysis of Phenotypic and Genotypic Antibiotic Susceptibility of Pasteurella multocida Isolated from Various Host Species in France and Hungary.
The study identified the most prevalent resistance genes in P. multocida as str A, sul 2, and tet H. Mutations in gyr A were associated with fluoroquinolone resistance.
Antimicrobial resistance reservoirs in salmon and broiler processing environments, sidestreams, and waste discharges.
The study identified several high-risk AMR genes in salmon and broiler processing environments, including multidrug resistance genes TolC and mdtE, tetracycline genes tet(L) and tet(M), aminoglycoside genes APH(3′)-IIIa and APH(6)-Id, and beta-lactam genes mecA and mecR1. Additionally, the study found quinolone-resistant Escherichia coli (QREC) in waste discharges from two broiler processing plants and multidrug resistant (MDR) E. coli in one plant.
Whole-genome sequencing reveals Enterobacter hormaechei as a key bloodstream pathogen in six tertiary care hospitals in southwestern Nigeria.
The study identifies several AMR genes in Enterobacter hormaechei and Enterobacter cloacae, including bla ACT-45, bla CTX-M-15, bla NDM-1, dfrA14, mcr10.1, aac(3)-Ile, aph(3′)-Ib, qnrB1, sul1, sul2, tet(A), catA1, and mphA, highlighting the prevalence of multidrug resistance in these species.
Resistance, virulence and genetic diversity of Salmonella Typhimurium in South Africa (1999-2021).
The study identified several AMR genes in Salmonella Typhimurium isolates from South Africa, including beta-lactamases (bla PSE, bla CMY-2, bla TEM, bla SHV), sulfonamide resistance genes (sul1, sul2, sul3), fluoroquinolone resistance genes (qnrA, qnrB, qnrS), tetracycline resistance genes (tetA, tetB), and trimethoprim resistance genes (dfrXI, dfrXII).
Diversity and antimicrobial resistance among bacterial isolates from finfish aquaculture in Thailand.
The study identified high levels of antimicrobial resistance in bacterial isolates from finfish aquaculture in Thailand, with particular emphasis on beta-lactam, tetracycline, and fluoroquinolone resistance in Gram-negative bacteria, and beta-lactam, macrolide, fluoroquinolone, and peptide resistance in Gram-positive bacteria. Unique resistance gene families, such as the SMR efflux pump and OXA beta-lactamase, were found in Aeromonas spp. and V. vulnificus.
The Road Less Traveled: Exploring the Genomic Characteristics and Antimicrobial Resistance Potential of Acinetobacter baumannii From the Indigenous Orang Asli Community in Peninsular Malaysia.
The study identified several beta-lactamase and cephalosporinase genes, including bla OXA-51, bla OXA-68, bla OXA-98, and various bla ADC variants, as well as tetracycline resistance gene tet(39) and aminoglycoside resistance gene ant(3'')-IIa in Acinetobacter baumannii isolates from the Orang Asli community. These genes contribute to resistance against carbapenems, cephalosporins, tetracyclines, and aminoglycosides.
Community gut colonization by tet(X4)-positive multidrug-resistant Escherichia coli in healthy individuals from urban residents in Shenzhen, China.
The study identifies tet(X4)-positive multidrug-resistant E. coli in healthy individuals from urban areas in Shenzhen, China, highlighting the presence of tigecycline resistance and other resistance genes in the community gut microbiota.
Genomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
The study identified high levels of antimicrobial resistance in Shigella boydii, with over 60% of isolates classified as multidrug-resistant. Key resistance genes included blaCTX-M-15, blaCTX-M-3, blaDHA-1, mphA, sul1, sul2, dfrA1, dfrA14, dfrA5, dfrA12, dfrA17, dfrA7, aadA1, aph(3’’)-Ib, aph(6)-Id, tet(A), and tet(B). Mutations in gyrA and parC were associated with ciprofloxacin resistance and reduced susceptibility.
Azithromycin resistance in nontyphoidal Salmonella in an urban informal settlement in Nairobi, Kenya.
The study identified several AMR genes in nontyphoidal Salmonella isolates, including aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, ant(3")-Ia, sul1, sul2, dfrA1, dfrA8, tetA, mph(A), bla CTX-M-3, bla TEM-135, bla TEM-1B, and bla TEM-1C. These genes conferred resistance to various antibiotics such as aminoglycosides, sulfonamides, tetracycline, macrolides, and beta-lactams.
Genomic insights into Shigella species isolated from small ruminants and manure in the North West Province, South Africa.
The study identified multiple antibiotic resistance genes in Shigella species isolated from small ruminants and manure in South Africa, highlighting the presence of multidrug-resistant strains and the diversity of resistance mechanisms.
Acquisition of novel antibiotic resistance genes by the bacterial predator Bacteriovorax sp. As-1.
Bacteriovorax sp. As-1 exhibits resistance to multiple antibiotics, primarily due to mutations in the gyrA gene, specifically S90Y and G94R, which are associated with reduced fluoroquinolone susceptibility.
Antimicrobial multidrug resistance of Escherichia coli from broiler farms in Zhanjiang, China.
The study identified multiple AMR genes in E. coli isolates from broiler farms in Zhanjiang, China, including bla TEM, bla AIM, pexA, aadA1, ant(3")-I, sul2, and sul3, which were associated with multidrug resistance to various antibiotics.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Assessing the Genomic Landscape of Salmonella enterica Isolated From Cattle Faeces on a Nigerian Farm.
The study identified AMR genes in Salmonella enterica isolates from cattle faeces, including aph(3')-Id, aph(6)-Id, qnrB19, sul2, tet(A), and fosA7, which confer resistance to aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and fosfomycin.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
Analysis of avian pathogenic Escherichia Coli (APEC) and its antimicrobial resistance risk characteristics and critical control points in laying hens.
The study identified several AMR genes in APEC isolates, including tet(A), floR, sul2, aph(3')-Ib, aph(6)-Id, bla TEM-1B, qnrS1, bla CTX-M-55, dfrA14, and mph(A), which contribute to resistance against tetracyclines, florfenicol, sulfonamides, aminoglycosides, beta-lactams, fluoroquinolones, and macrolides.
Antimicrobial resistance and virulence profiling of waterfowl-derived Salmonella in Sichuan from 2021 to 2023.
The study identified multiple antimicrobial resistance genes in waterfowl-derived Salmonella isolates, including aac(6')-Iaa, bla_OXA-1, bla_CTX-M-65, catB3, sul2, fosA3, lnu(F), dfrA17, and cfr. These genes conferred resistance to various antibiotics, highlighting the multidrug resistance profile of the isolates.
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Multidrug resistant hypervirulent ST307 clone from genomic surveillance of extended spectrum beta-lactamase-producing Klebsiella pneumoniae species complex in East Africa.
The study identifies multiple AMR genes, including blaCTX-M-15, blaTEM-1D, aac(6')-Ib-cr, aadA16, strB, qnrS1, sul2, sul1, catII.2, tet(A), dfrA14, arr-3, and mphA, in ESBL-KpSC isolates from East Africa, highlighting the prevalence of multidrug resistance.
Comparative assessment of annotation tools reveals critical antimicrobial resistance knowledge gaps in Klebsiella pneumoniae.
The study identifies various AMR genes and mutations in Klebsiella pneumoniae, highlighting knowledge gaps in existing annotation tools and databases for accurate resistance prediction.
Characterization of Enterobacter cloacae complex clinical isolates: comparative genomics and the role of the efflux pump AcrAB-TolC over-expression and NDM-1 production.
The study characterizes carbapenem-resistant Enterobacter cloacae complex isolates, highlighting the roles of the AcrAB-TolC efflux pump over-expression and the bla NDM-1 carbapenemase in conferring resistance. Multiple resistance genes, including bla NDM-1, acrAB-tolC, and various beta-lactamases, aminoglycoside-modifying enzymes, and sulfonamide resistance genes, were identified and validated.
Contribution of maternal gut carriage to neonatal acquisition of extended-spectrum beta-lactamase-producing Enterobacterales in Madagascar and Cambodia.
Maternal gut carriage contributes to only 16.5% of neonatal acquisition of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE), with blaCTX-M-15, blaCTX-M-55, blaCTX-M-27, blaNDM-5, blaNDM-1, sul2, aph(3')-Ib, aph(6)-Id, and tet(A) identified as key resistance determinants.
Global geographic and genomic epidemiology analysis of carbapenem-resistant Escherichia coli carrying bla(NDM-9).
The study characterizes bla NDM-9 -carrying carbapenem-resistant Escherichia coli (CREC) and identifies various antibiotic resistance genes (ARGs) contributing to multidrug resistance. It highlights the role of mobile genetic elements in the dissemination of bla NDM-9 and emphasizes the importance of surveillance for these high-risk clones.
Genetic insights into antimicrobial resistance and virulence characteristics of Salmonella enterica isolated from Nile tilapia sourced from retail markets in Thailand.
The study identified multiple antimicrobial resistance (AMR) genes in Salmonella enterica isolates from Nile tilapia, including beta-lactamases (bla TEM−1B, bla CTX−M−55, bla CTX−M−14, bla LAP−2), quinolone resistance genes (qnrS1, qnrS13), tetracycline resistance genes (tet(A), tet(B), tet(M)), aminoglycoside resistance genes (aadA2, aph(3’’)-Ib, aph(6)-Id, aac(6’)-Ia), sulfonamide resistance genes (sul1, sul2, sul3), florfenicol resistance gene (floR), and efflux pump systems (mdsABC, mdtK).
Genomic and In Vivo Characterization of Antimicrobial Resistance and Virulence in UPEC Escherichia coli Isolated from Brazilian Cases of UTI.
The study identified multiple antimicrobial resistance genes in UPEC strains, including aac(3)-IId, AAC(6')-Ib-cr, APH(3')-Ib, APH(6')-Ib, sul2, dfrA17, tet(B), TEM-1, OXA-1, and SHV-12, which confer resistance to aminoglycosides, sulfonamides, tetracycline, and beta-lactams.
Diversity of Multi-Drug Resistance Genes in Escherichia coli Isolated from Poultry in Southern Togo.
The study identified multiple AMR genes in E. coli isolates from poultry in southern Togo, including blaCTX-M-55, sul2, tet(A), floR, aph(6)-Id, aph(3")-Ib, gyrA, gyrB, parC, parE, pmrA, pmrB, folp, 23S, 16S-rrsB, 16S-rrsC, 16S-rrsH, ampC-promoter, rpoB, and mcr-1.1. These genes confer resistance to various antibiotics, highlighting the prevalence of multidrug resistance in poultry-associated E. coli.
Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.
The study identified multiple AMR genes in Citrobacter freundii isolates from Egyptian livestock, including bla TEM, bla CTX-M, bla OXA-10, bla CMY-2, qnrA, aadA1, sul2, dfrA1, ermB, tet(M), int1, and mcr-1, which confer resistance to various antibiotics.
Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.
The study identified multiple AMR genes in Citrobacter freundii isolates from Egyptian livestock, including bla TEM, bla CTX-M, bla OXA-10, bla CMY-2, qnrA, aadA1, sul2, dfrA1, ermB, tet(M), int1, and mcr-1, which confer resistance to various antibiotics.
Research of antimicrobial resistance and its associated genes distribution in Escherichia coli from diarrheic calves in the Ulagai region of China.
The study identified several antimicrobial resistance genes in E. coli isolates from diarrheic calves in the Ulagai region of China, including sul2, TEM-1, tetR, strB, QacH, floR, and CTXM-55, which were associated with resistance to various antibiotics.
Genomic diversity and antimicrobial resistance of Vibrio cholerae isolates from Africa: a PulseNet Africa initiative using nanopore sequencing to enhance genomic surveillance.
The study identified a high prevalence of trimethoprim resistance genes (dfrA1, dfrA15, dfrA31) and other resistance genes such as floR, strA, strB, varG, blaCARB-2, aadA1, aadA2, sul1, sul2, catB9, tet(C), tet(G), tet(59), qacEdelta, and blaCMY-4 in Vibrio cholerae isolates from Africa. Fluoroquinolone resistance mutations (gyrA_S83I and parC_S85L) and nitrofuran resistance mutations (nfsA_R169C and nfsB_Q5*) were also prevalent.
Genomic Characterization and Resistance Mechanisms of Carbapenem-Resistant Klebsiella pneumoniae ST101 Isolates from Saudi Arabia.
The study identifies bla_OXA-48 and bla_NDM-1 carbapenemase genes in CRKP ST101 isolates from Saudi Arabia, highlighting their role in carbapenem resistance and the complexity of resistance mechanisms in high-risk clones.
PanARGMiner (Pan-Genomic Antimicrobial Resistance Gene Miner): An advanced feature selection framework for extracting key resistance genes from pan-genomic datasets.
PanARGMiner effectively identifies key resistance genes from pan-genomic datasets, including both known and novel AMR genes, across multiple bacterial species.
Genomic analysis of multidrug-resistant Salmonellaenterica Serovar Montevideo isolates in China.
The study identified multiple AMR genes in Chinese S. Montevideo isolates, including beta-lactamases (bla TEM−1B, bla OXA−1, bla LAP−2, bla CTX−M−55, bla CTX−M−65, bla DHA−1), quinolone resistance genes (qnrS2, qnrS1, qnrA1, qnrB6, qnrB4, qepA1), macrolide resistance genes (mphA, mphE, msrE, mphB), tetracycline resistance genes (tetA, tetD, tetB), sulfonamide resistance genes (sul1, sul2, dfrA14, dfrA12, dfrA27, sul3), and chloramphenicol resistance genes (floR, catA2, catB3).
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
Comparative genomics reveals avian Acinetobacter baumannii as antimicrobial resistance reservoirs and bovine strains with elevated pathogenicity.
Avian Acinetobacter baumannii strains were found to carry a significantly higher number of antimicrobial resistance genes compared to bovine and porcine strains, highlighting their potential role in the dissemination of antimicrobial resistance through animal origin foods.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Genomic characterization and comparative analysis of multidrug-resistant Escherichia coli ST361 from urban wetland.
The study identifies multidrug-resistant Escherichia coli ST361 from urban wetlands in India, highlighting the presence of resistance genes such as pmr, tolC, acr, and sul2, which confer resistance to polymyxins, beta-lactams, sulfonamides, and other antibiotics.
Antibiotic contamination and antimicrobial resistance dynamics in the urban sewage microbiome in India.
The study identifies multiple antibiotic resistance genes (ARGs) in urban sewage samples from India, highlighting the presence of genes such as blaTEM, catB, aac(6')-Ib, sul1, ermB, dfrA1, mphA, sul2, blaOXA, blaCTX-M, and qnrS, which confer resistance to various antibiotic classes.
Unveiling Equine Abortion Pathogens: A One Health Perspective on Prevalence and Resistance in Northwest China.
The study identified multiple antibiotic resistance genes in equine abortion pathogens, including CTX-M, TEM-1, TetM, ermA/B/C, qnrA/B, sul1/2, dfrA1/5, SHV, OXA-1, OXA-23/48/58, mecA/B/C, IMP-1/2, NDM-1, VIM-1/2, and vanA/B/C, highlighting the widespread resistance to various antibiotics among these pathogens.
Slaughterhouse Wastewater as a Reservoir of Thermotolerant E. coli With Antimicrobial Resistance and Virulence Potential in Dhaka, Bangladesh.
The study identified several AMR genes in E. coli isolates from slaughterhouse wastewater, including blaTEM, blaCTX-M-15, blaIMP-1, blaIMP-4, blaOXA-48, dfrA17, tetA, sul2, and qnrS, highlighting the presence of multidrug-resistant strains.
Genomic epidemiology of Salmonella Typhimurium and its monophasic variants in Southern China: A spatiotemporal and source attribution analysis.
The study identified blaTEM-1, tet(A), and sul2 as the most prevalent antimicrobial resistance genes in Salmonella Typhimurium isolates from Jiangxi Province, China. Additionally, point mutations in the quinolone resistance-determining region of the gyrA gene were found to be responsible for ciprofloxacin resistance.
Plasmid-mediated florfenicol resistance in Pasteurella trehalosi., Evolution of a multiple antibiotic resistance region in IncHI1 plasmids: reshaping resistance regions in situ., New plasmid-borne antibiotic resistance gene cluster in Pasteurella multocida., Nucleotide sequence and organization of plasmid pMVSCS1 from Mannheimia varigena: identification of a multiresistance gene cluster., Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constins., Small multidrug resistance plasmids in Actinobacillus porcitonsillarum., Comparison of multidrug resistance gene regions between two geographically unrelated Salmonella serotypes., Electrotransformation of Haemophilus parasuis with in vitro modified DNA based on a novel shuttle vector.
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