sxtP

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MFS efflux pump

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UniProt

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Validation StatusCandidate

Overview

Mechanism: efflux-mediated resistance
Validation Method: knockout experiments and MIC testing
Drug Classes: sulfamethoxazole, trimethoprim, trimethoprim sulfamethoxazole
Organisms: Acinetobacter baumannii
Papers: 1
Databases: Reslit

Papers1

The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of Acinetobacter baumannii.

PMID 39194207 · 2024

The study identifies and characterizes the novel MFS efflux pump SxtP and its regulatory LysR-type transcriptional activator SxtR, which are involved in resistance to sulfamethoxazole/trimethoprim and contribute to the pathogenesis of Acinetobacter baumannii.

Gene Information

Gene Name: sxtP
Allele: sxtP
Encodes: MFS efflux pump
Source Database: Reslit
Mechanism: efflux-mediated resistance
Confers Resistance To: sulfamethoxazoletrimethoprimtrimethoprim sulfamethoxazole
Organisms Tested In: • Acinetobacter baumannii
Validation Method: knockout experiments and MIC testing
Sequence Accession: CP018664.1

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sxtP

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sxtP

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