sxtR

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LysR-type transcriptional activator

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Validation StatusCandidate

Overview

Mechanism: transcriptional activation of sxtP
Validation Method: EMSAs and RT-qPCR
Drug Classes: trimethoprim sulfamethoxazole
Organisms: Acinetobacter baumannii
Papers: 1
Databases: Reslit

Papers1

The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of Acinetobacter baumannii.

PMID 39194207 · 2024

The study identifies and characterizes the novel MFS efflux pump SxtP and its regulatory LysR-type transcriptional activator SxtR, which are involved in resistance to sulfamethoxazole/trimethoprim and contribute to the pathogenesis of Acinetobacter baumannii.

Gene Information

Gene Name: sxtR
Allele: sxtR
Encodes: LysR-type transcriptional activator
Source Database: Reslit
Mechanism: transcriptional activation of sxtP
Confers Resistance To: trimethoprim sulfamethoxazole
Organisms Tested In: • Acinetobacter baumannii
Validation Method: EMSAs and RT-qPCR
Sequence Accession: CP018664.1

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sxtR

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sxtR

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