The study identifies Tet38 as an efflux pump in Staphylococcus aureus that confers resistance to tetracycline and certain unsaturated fatty acids, and it plays a role in the internalization and survival of the bacterium in epithelial cells.

The study identified multiple antimicrobial resistance (AMR) genes associated with the International Space Station (ISS) environmental surfaces, highlighting the presence of resistance mechanisms against various antibiotics, including beta-lactams, fluoroquinolones, and tetracyclines. Notably, genes such as mecA, blaZ, and qacB were detected, indicating resistance to methicillin, penicillin, and quaternary ammonium compounds, respectively.

The study identifies tet38 as a gene that is over-expressed in Staphylococcus aureus when co-cultured with Pseudomonas aeruginosa, leading to increased tetracycline resistance and internalization into epithelial cells.

The study identified several AMR genes using Nanopore sequencing, including mecA, blaTEM-4, blaTEM-112, blaTEM-157, blaACT-5, oqxB, tetC, ermA, erm (33), tet38, ant(4′)-lb, tetK, tetQ, sul1, dfrA, acrF, parE, mfd, mphA, aadA5, vgaC, blaACT-5, blaACT-14, mefA, mel, tetX, tetM, isaC, and aadA5, which conferred resistance to various antibiotics such as methicillin, ticarcillin, ceftazidime, erythromycin, clindamycin, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and levofloxacin.

The study characterized methicillin-resistant Staphylococcus aureus (MRSA) isolates, identifying genes such as mecA, blaZ, norA, gyrA, gyrB, tet-38, mepA, mepR, arlS, arlR, mgrA, clsA, dfrC, msbA, rpoB32, mprF, and mrpA, which confer resistance to various antibiotics.

The study identified various antimicrobial resistance genes in MRSA isolates from human, chicken, and environmental samples in Nigerian live bird markets, highlighting the presence of multidrug-resistant strains and the potential public health risks associated with their dissemination.

The study identified various AMR genes and mutations associated with daptomycin resistance in MRSA strains, including genes such as aac(6')-Ib, blaZ, mecA, ermC, fexB, tetM, tet38, dfrC, fosD, and vgaA, as well as mutations in mprF, rpoB, grlA, grlB, and gyrA.

The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.

The study identified several AMR genes in ST72 isolates, including blaZ, aadD, ermC, msr(A), mph(C), tetK, aac(6')-aph(2'), fusC, and dfrG, which confer resistance to various antibiotics. K07-204 showed resistance to methicillin, ampicillin, erythromycin, kanamycin, and tetracycline, while K07-561 exhibited resistance to ampicillin and tetracycline. Additionally, K07-204 was found to be highly resistant to lysostaphin.

The study identifies key residues in the Staphylococcus aureus Tet38 efflux pump that are essential for tetracycline, fosfomycin, tunicamycin, and palmitoleic acid resistance, as well as host cell internalization. Specific mutations in motifs B and C and external loops significantly impact resistance and cellular interactions.

The study identified a novel genotype of methicillin-susceptible Staphylococcus aureus (HS-MSSA) that caused a fatal sepsis case. The strain carries a strain-specific blaZ-bearing plasmid, indicating resistance to penam antibiotics.

The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.

The study identified three antibiotic resistance genes (blaZ, fosB, and tet38) in Staphylococcus aureus using shotgun-metagenomics. These genes were associated with resistance to penicillin, fusidic acid, and tetracycline.

The study identified 14 AMR-associated genes, including blaI, blaR1, blaZ, tet(38), merR1, and norB4, in S. aureus isolates from New Zealand dairy cattle. These genes were associated with resistance to penicillin, tetracycline, mercury, and ciprofloxacin. The presence of resistance genes remained low, and no significant associations were found between resistance genes and antimicrobial usage or dry cow therapy.

The study identified 18 antimicrobial resistance genes in Staphylococcus aureus strain DC.RB_015, including mecA, blaZ, mepA, tet(K), tet(38), arlR, arlS, norA, mgrA, LmrS, APH(3′)-IIIa, aad(6), ErmB, SAT-4, mecR1, GlpT, murA, and bacA, which confer resistance to various antibiotics such as methicillin, beta-lactam, tetracycline, fluoroquinolone, macrolide, aminoglycoside, nucleoside, fosfomycin, and bacitracin.

The study identified a novel strain of Macrococcus caseolyticus, DaniaSudan, which exhibits resistance to several antibiotics, including ciprofloxacin, ceftazidime, erythromycin, oxacillin, clindamycin, and kanamycin. The strain was found to possess resistance genes such as ANT(4')-Ib, mecA, mecI, mecR1, and Tet(38).

The study identifies Tet38 as a tetracycline efflux pump in Staphylococcus aureus, regulated by the KdpD/E system. It shows that Tet38's expression is repressed under salt stress, and its overexpression affects sodium tolerance in E. coli.

The paper discusses the molecular mechanisms of drug resistance in Staphylococcus aureus, focusing on beta-lactam, glycopeptide, oxazolidinone, MLS-B, aminoglycoside, and other resistance mechanisms. Key genes identified include blaZ, mecA, mecC, vanA, cfr, ermA, ermC, aac(6')-Ib, aph(3')-IIIa, and aadD. Mutations in pbp2 and pbp2a were also found to contribute to resistance.

The study identified several AMR genes in methicillin-resistant staphylococci isolates from goats and their farm environments in Saudi Arabia, including mecA, blaZ, norA, lmrS, mepA, mepR, arlR, arlS, tet(38), mecR1, dfrC, fusC, fosB, fexA, tetM, msrA, mphC, fusB, APH(3′)-IIIa, tetK, and dfrG. These genes confer resistance to various antibiotics such as penicillins, fluoroquinolones, aminoglycosides, macrolides, phenicols, diaminopyrimidines, oxazolidinones, tetracyclines, and fosfomycin.

The study identified several AMR genes and mutations in S. aureus strains isolated from ready-to-eat foods in Algeria, including blaZ, ermB, lmrS, tet(L), tet(38), aph(3')-IIIa, ant(6)-I, mecA, and a gyrA mutation (S84L) conferring resistance to various antibiotics.

The study identifies tetracycline resistance genes tet-38 and mepA/R in Staphylococcus aureus BIAI isolates, highlighting their limited acquired antibiotic resistance mechanisms.

Two linezolid-resistant MRSA strains from pigs in Germany were identified, both harboring plasmid-encoded cfr genes. These strains also had additional AMR genes, indicating multidrug resistance.

The study identified AMR genes such as tet(38), fosB-Saur, and blaZ in bovine mastitis milk using a rapid, culture-independent method involving MinION nanopore sequencing and optimized DNA isolation protocols.

The study identified PVL-positive CC398 MRSA strains in the Netherlands, highlighting their potential for community acquisition and the importance of genomic surveillance for early detection.

The study identified several AMR genes in Staphylococcus aureus isolates from a Brazilian veterinary hospital, including blaZ, mecA, norA, norC, tetM, tet38, ermA, and ermB, which confer resistance to various antibiotics such as penicillin, methicillin, tetracycline, and erythromycin.

The study identified multiple antibiotic resistance genes in Staphylococcus aureus isolates from raw shrimp in China, including mecA, mecR1, blaZ, aph(3')-IIIa, aad(6), ANT(4')-Ib, tet(K), mph(C), lnu(A), ermB, ermC, dfrC, dfrG, fosB, SAT-4, rpoB, msr(A), mepA, mepR, norA, mgrA, tet(38), sav1866, arlR, and arlS, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramins, trimethoprim, fosfomycin, and others.

The study identified blaZ, norA, norC, tet38, and icaD genes in multidrug-resistant Staphylococcus aureus isolates associated with subclinical mastitis. These genes were linked to resistance against penicillin, tetracycline, macrolides, fluoroquinolones, and biofilm formation.

The study identifies several multidrug efflux system genes (norA, norB, norC, lmrS, tet38, msrA) in Staphylococcus aureus isolates from human, animal, and food sources, highlighting their role in resistance to various antibiotics.

The study identified various antimicrobial resistance genes in Staphylococcus species isolated from diabetic foot ulcers and healthy skin, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, macrolides, tetracyclines, fusidic acid, trimethoprim-sulfamethoxazole, fosfomycin, kanamycin, neomycin, and quaternary ammonium compounds.

The study identified various antimicrobial resistance (AMR) genes in bacterial positive blood cultures using nanopore sequencing, demonstrating the effectiveness of this method in detecting resistance mechanisms and pathogens quickly.

The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from both patients and retail meat, including blaZ, fosB-Saur, tet38, mphC, msrA, sat4, mecA, aph(3')-IIIa, and fusC. These genes were associated with resistance to various antibiotics such as penicillin, tetracycline, macrolides, and fusidic acid.

The study identified several AMR genes in MRSA isolates causing invasive infections in Paraguayan children, including mecA, blaZ, ermC, aac(6')-aph(2"), tet(38), cat(pC221), fos-B-Saur, and rphC, which confer resistance to various antibiotics such as methicillin, penicillin, erythromycin, clindamycin, gentamicin, tetracycline, chloramphenicol, and rifampin.

The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from Vermont dairy farms, including beta-lactam resistance genes (blaZ, blaI, blaR), tetracycline resistance genes (tet(K), tet(38)), erythromycin resistance genes (erm(T), erm(A)), lincomycin resistance gene (lnu(G)), aminoglycoside resistance genes (aaC3, ant(9)-la), multidrug resistance efflux pumps (lmrS, mepA, mepR, mepB, norA, norB, arlS, arlR, mgrA), and fosfomycin resistance gene (fosB).

The study identified multiple antimicrobial resistance genes in S. aureus isolates from sternal bursitis in chickens, including aph(3')-IIIa, tetK, tet38, ermC, parC, and fosB, which confer resistance to aminoglycosides, tetracyclines, macrolides, fluoroquinolones, and fosfomycin.

Phenazine-1 carboxylic acid (PCA) induces the expression of the Staphylococcus aureus Tet38 MDR efflux pump, leading to resistance against tetracycline and certain phenazines.

The study identified six antibiotic-resistance genes in the S. argenteus strain 22WJ8192, including blaZ, blaI_of_Z, blaR1, aph(3')-IIIa, tet(38), and fosB-Saur, which conferred resistance to penicillin, amikacin, tetracycline, and fosfomycin. These genes were found to be more prevalent in human-origin strains compared to nonhuman-origin strains.

The study identified multidrug-resistant Staphylococcus aureus isolates, including MRSA-ST80, carrying various AMR genes such as mecA, blaI, blaZ, ermC, aph-S-tph, dha1, norA, tet38, mepA, lmrS, and fosB. Mutations in gyrA and parC were associated with fluoroquinolone resistance.

The study found that doxy-PEP use over 6 months significantly increased the proportion and expression of tetracycline resistance genes in the gut microbiome, with no significant changes in other antibiotic resistance gene classes.

The study identifies AMR genes and mutations associated with the clonal replacement of MRSA strains in a Malaysian hospital, highlighting the role of desiccation tolerance and reduced antibiotic resistance.

The study identified a bovine isolate carrying the extended-spectrum beta-lactamase gene blaTEM-116, highlighting concerns about antimicrobial resistance in dairy farm environments. Multiple antimicrobial resistance genes were detected in both bovine and human isolates, including genes conferring resistance to tetracyclines, penicillins, fosfomycin, and aminoglycosides.

The study identifies various antimicrobial resistance genes in Staphylococcus aureus isolates from patients with chronic rhinosinusitis, including blaI, blaZ, blaPC1, blaR1, erm(T), erm(A), tet(38), mepA, fosB, and ermC, which confer resistance to penicillin, macrolides, lincosamides, streptogramins, tetracycline, and fosfomycin.

AmrProfiler identifies a wide range of AMR genes and mutations across multiple bacterial species, demonstrating high accuracy and broader species coverage compared to existing tools.

The study identifies NorA and Tet38 efflux pumps as critical for Staphylococcus aureus survival in the cystic fibrosis airway environment and resistance to antibiotics. Mutations in the norA promoter, including CAAT, ACAA, and CTAT insertions, were found to enhance norA expression and contribute to increased resistance to ciprofloxacin and pyocyanin.

The study identified four core antimicrobial resistance genes (dfrC, mgrA, norA, and tet(38)) in bovine-derived Staphylococcus chromogenes isolates, which confer resistance to trimethoprim, fluoroquinolones, and tetracyclines. In contrast, porcine-derived isolates harbored a more diverse set of resistance determinants.

The study identified several AMR genes in Staphylococcus aureus ST1 isolates from New Zealand, including blaZ, tet(38), mecA, mecR1, qacA, qacB, ermC, fusC, mupA, and others. These genes were associated with resistance to various antibiotics such as penicillin, tetracycline, methicillin, quaternary ammonium compounds, erythromycin, fusidic acid, mupirocin, and fluoroquinolones. The study also highlighted the presence of a novel prophage, φSabovST1, in bovine ST1 isolates, which encoded bovine-adapted leukocidins.

The study identified methicillin-resistant Staphylococcus aureus (MRSA) in pets and their owners in Bangladesh, highlighting the zoonotic potential of MRSA. Key AMR genes included mecA, tetA, tetK, tet(38), and blaZ, which conferred resistance to methicillin, tetracycline, and penicillin.

The study reports the first detection of livestock-associated Methicillin-Resistant Staphylococcus aureus ST398 in wild birds in Brazil, highlighting the emergence of antimicrobial-resistant S. aureus in a protected Atlantic Forest fragment. The MRSA isolates exhibited a broad resistome, including genes for resistance to multiple antimicrobial classes.