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Explore antimicrobial resistance genes from the literature
tetracycline inactivation enzyme
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| tet(51) | Card DatabaseResFinder Database | 2 | TETRACYCLINE | uncultured bacterium | - | 2015 | KR857685.1 | AKQ05895.1 |
| Tet(51) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | TETRACYCLINE, tetracycline | uncultured bacterium +1 | - | 2015, 2017 | KR857685.1 | AKQ05895.1 |
| tet51 | Reslit | 1 | tetracycline | Legionella longbeachae | - | 2018 | PDB:4a6n | - |
The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.
The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.
The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.
The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.
Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
The study identifies and characterizes several tetracycline destructases, including tet(56), tet(X), tet(50), tet(51), and tet(55), which confer tetracycline resistance through enzymatic inactivation. These enzymes degrade tetracycline, leading to increased minimum inhibitory concentrations (MICs) in E. coli. Additionally, anhydrotetracycline is identified as an inhibitor of these enzymes, restoring tetracycline activity.
Tetracycline-Inactivating Enzymes.
The paper reviews the structure, mechanism, and inhibition of tetracycline-destructase enzymes, highlighting their role in enzymatic inactivation of tetracyclines and the identification of new tetracycline destructase genes such as tetX, tetX1, tetX2, tet49, tet50, tet51, tet55, and tet56.
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