Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline efflux MFS transporter Tet(A)
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G262D | - | - | - | tigecycline | Reslit | Candidate |
| A395V | - | - | - | tigecycline | Reslit | Candidate |
| S251A | - | Klebsiella pneumoniae | tigecycline|tetracycline|doxycycline|minocyclinetigecycline | Reslit | Candidate | |
| L120S | - | - | Salmonella enterica | tigecycline | Reslit | Candidate |
| L121P | - | - | Salmonella enterica | tigecycline | Reslit | Candidate |
| L181P | - | - | Salmonella enterica | tigecycline | Reslit | Candidate |
| G300E | - | Escherichia coli, Klebsiella pneumoniae | tigecycline | Reslit | Candidate | |
| V55M | - | positive role in conferring tigecycline resistance | E. coli | tigecycline | Reslit | Candidate |
| F163Y | - | - | Klebsiella pneumoniae | tigecycline | Reslit | Candidate |
| I248L | - | Klebsiella pneumoniae | tigecycline | Reslit | Candidate | |
| A370V | - | Klebsiella pneumoniae | tigecycline | Reslit | Candidate | |
| A53G | - | Klebsiella pneumoniae | tigecycline | Reslit | Candidate | |
| A264V | - | Klebsiella pneumoniae | tigecycline | Reslit | Candidate | |
| G237V | - | Klebsiella pneumoniae | tigecycline | Reslit | Candidate | |
| G300V | - | Klebsiella pneumoniae | tigecycline | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Tet(A) | Reference Gene CatalogReslit | 534 | TETRACYCLINE, tetracycline +5 | Vibrio cholerae +203 | United States, Europe, North Carolina|Ohio, Denmark, Sweden, Pennsylvania, Canada, Japan|United States, Texas, Germany, Galápagos Archipelago, China, Ireland, Tunisia, Korea, Southern Ontario, Canada, US|Afghanistan, Japan, Oman, India, Brazil|China|Hong Kong|Indonesia|Israel|Nigeria|Peru|Singapore|Thailand|Vietnam, Iran, South West London, UK, Lower Saxony|Germany, Global, Austria, South Korea, Nigeria, Denmark|Europe, Germany|Denmark|Sweden|France|Italy, southwestern Nigeria, Italy, Europe|Italy, Poland, Portugal, Kenya, Nepal|Japan, Tanzania, Norway, Germany|France|Netherlands|Belgium, New York|Washington, Zimbabwe, North Carolina, Europe|Spain, North Carolina|China, Ethiopia, Guangxi, China, Hong Kong, SAR, China|Hong Kong, Pakistan, France, Alberta, West Africa|Conakry, Guinea, Cameroon, Antarctic Peninsula, UK|Latin America, Ghana, Singapore, Chile, Europe|United States|China|Brazil|Australia|Spain|Germany|Iran|Switzerland|France|Portugal|Japan|Belgium|South Korea|Vietnam|Taiwan|India|Egypt|South Africa|Algeria, Lebanon, Switzerland, South Asia|sub-Saharan Africa|The Gambia|Mali|Kenya|Mozambique|Bangladesh|India|Pakistan, China|Three Gorges Reservoir (TGR), China, Egypt, Germany|Vietnam|Egypt, Thailand|Japan, Bangladesh|Pakistan|Nepal, Africa|Ghana|Kenya|Tanzania, Rio de Janeiro, Brazil, South-Kivu Province, Democratic Republic of Congo, Malawi, Denmark|France|Poland|Italy|Hungary|Germany|Estonia|United States, Sri Lanka, Spain, Brazil, Taiwan|Germany|Netherlands|United Kingdom|United States, Indonesia, South Africa, Greece, Germany|global, Portugal|Spain|France, H1 Hospital, Philippines, Czech Republic, Great Britain, mid-Adriatic coast, Shanghai, China, USA, USA|Peru|Egypt|Cambodia|Kenya, Vietnam|China, North America, Europe|Poland, Sweden|India|Global, Denmark|Finland|Iceland|Lithuania|Netherlands|Spain, Kenya|Malawi, Australia, Uruguay, Saudi Arabia, Bangladesh, Russia, Guadeloupe|French West Indies, Armenia|Georgia, Pacific region|Hawaii, East Coast Peninsular Malaysia, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, Europe|Spain|Hungary|Germany|France|Belgium|Poland|United Kingdom|Denmark, California|Europe|North America|Republic of Congo, Sicily|Italy, United Kingdom|England|Australia, Mexico|Mexico City, Europe|broiler production pyramid, Northern Portugal, Cambodia, England|Wales, East Asia, Africa|North America|South America|Asia|Europe, North Carolina|USA, Victoria, Australia, Uganda|Kenya, Guangdong, Madagascar, Caribbean, Finland|Eastern Finland, Milwaukee, Wisconsin, USA|USA, Taiwan, Japan|France|United Kingdom|North America|South America|Europe|Asia/Oceania|Africa, North-Western Mexico, Malaysia, Europe|EU|China|Portugal|Germany, Thailand, Southwestern China, central Adriatic Sea|Croatia|Croatian marine environment, Sudan, Hungary, Spain|Peru, Europe|USA|Portugal|Germany|Australia|China|India|Pakistan|Sweden|Colorado, Saskatchewan, Ethiopia|Kenya, Hong Kong, Ningxia, China|China, Zhejiang Province, China, Basque Country, northern Spain|Basque Country, South Australia|Australia, Alberta, Canada, North Sea|Baltic Sea, Baghdad, Khon Kaen province, Thailand, Guadeloupe, Al-Kharj, KSA, Burkina Faso, Shandong Province, China, Portugal|Spain|Italy|Morocco, Yangzhou, China, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Ontario, Canada, Midwestern U.S.|Nebraska, Belgium|The Netherlands|Europe, Comunitat Valenciana|Spain, United Kingdom|High-risk countries, southwestern Siberia, Spain|Asturias, Spain, Southern California, West Texas, USA, Kuwait, Shenzhen, China|China, Northern Italy, Finland, East Africa, Argentina, China|Bolivia|United States|Canada|New Zealand, Mozambique, Tamaulipas, Mexico, Salish Sea, Uganda, Central Adriatic|Central Adriatic Sea, Tennessee, USA|East Tennessee, Shandong Province, China|United States|United Kingdom, Turkey, Bangkok, Thailand, China|Europe|Asia|North America|South America, Denmark|Finland|Germany, Guangzhou, Baton Rouge, LA, United States|Pakistan|Bangladesh|Nigeria|Iraq|India, Netherlands|Kenya|United States|India|Tanzania, Bulgaria, Europe|Russia, Pakistan|China|United States|United Kingdom|Canada|Australia|Spain|Denmark|UAE|Ethiopia|India|South Asia, Rwanda, France|Germany|Netherlands|Norway|Spain|United Kingdom|Europe, Europe|Canada, Europe|Czech Republic, Armenia, Latin America, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, California, Terengganu, Malaysia|Malaysia, Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom, Saboba district|Bolgatanga Municipality, Southern Thailand, Israel, Iowa, United States, Republic of Korea, Europe|China|Thailand, Guangzhou, China, Shanghai|Minhang District, Western Balkans|Hungary, Costa Rica, North Carolina, USA, Shandong Province|adjacent regions in China, Guangdong, China, Germany|Spain|UK|Vietnam, Northeast China, Atlanta, Shenzhen, China, Australia|France|Bangladesh|United States, China|United Kingdom|Argentina|Europe|Americas|Asia|Africa|Australasia|Vietnam|Switzerland|Thailand|Mexico, East Africa|Tanzania|Uganda, Madagascar|Cambodia, Algeria, United Arab Emirates, Southern Togo|Togo, Vietnam, Colombia, Kazakhstan, Southern China | 1999, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AB114188.1 | BAC79064.1 |
| tet | Reslit | 68 | tetracycline, oxytetracycline | Chlamydia suis +58 | Nebraska|Iowa, France, India, Europe, Orissa, Eastern India, Iraq, Uganda, Russia|Siberian Russia, Brazil|United States|China|South Korea, United States|China|Malawi|Venezuela, Southern Africa, Dublin, Hong Kong, SAR, China|Hong Kong, Croatia|India, China, Korea, USA|France|Portugal|China|Brazil|Germany|Sweden|Italy|Spain|Denmark|Japan|Korea|Europe|Asia|North America, Zhejiang Province, China|China, Italy|Germany|Denmark|United Kingdom|Ireland|Poland|United States, Shandong province, China|Shandong Province, China, Kenya, Rwanda, South Korea, Europe|Asia|Africa|North America|South America|Australia|Thailand|South Korea|Vietnam|China|Poland|Iran|Egypt|India|Finland|Cambodia|Nigeria|Malaysia|United Kingdom|Germany|Sweden|New Zealand|Northern Ireland|Taiwan|Denmark|France|USA, Australia, Brazil, Japan, South America|Africa|Peru|Tanzania, Tunisia, Gulf Cooperation Council (GCC) region|Gulf Cooperation Council region, China|Shanghai, China, Global, Canada, Moscow, Russia, South Africa, Tripura, Ede, Nigeria|Ede, Osun State, Nigeria, Europe|Poland, Zoba Anseba, Eritrea, Mayurbhanj, Odisha, India|India, Asia|China | 1980, 1981, 1986, 1987, 1996, 2001, 2006, 2009, 2011, 2012, 2014, 2015, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | DS:71627|AM943017 | - |
| tet (A) | Reslit | 39 | tetracycline, doxycycline +1 | Salmonella typhimurium +24 | Europe, Peru|Bolivia, Bolivia, South West London, UK, Peru, Northern Tanzania, Japan, Pakistan|Thailand, United Kingdom, Germany, North America|Washington, Vietnam, Minnesota|Wisconsin|North Dakota, China, Finland|Eastern Finland, Edo state, Nigeria, Romania, Denmark, Italy, Ontario, Canada, United States, Brazil, Austria, Spain, Europe|Netherlands, Guangdong, China | 2004, 2006, 2007, 2008, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | DRA004833 | - |
| tet(A)-1 | Reslit | 1 | tetracycline | Salmonella enterica subsp. enterica serovar Typhimurium | United Kingdom|Africa | 2017 | LT855376|LT855377|CP031525|CP031526 | - |
| tet(A)-like | Reslit | 1 | tetracycline | - | West Africa|Conakry, Guinea | 2018 | PRJNA421654|PJMH00000000|PJMI00000000|PJMJ00000000|PJMK00000000|PJML00000000|PJMM00000000 | - |
| tetA-A | Reslit | 1 | tetracycline | Acinetobacter baumannii | Global | 2020 | - | - |
| tetA-G | Reslit | 1 | tetracycline | Acinetobacter baumannii | Global | 2020 | - | - |
| tetA' | Reslit | 1 | tetracycline | Escherichia coli | Europe | 2021 | MT720905|MT441554|MT720906|MT720903|MT720902|MT720904 | - |
| TET | Reslit | 1 | tetracycline | Salmonella Typhimurium | China | 2021 | - | - |
| tet(A)-v | Reslit | 1 | tetracycline, tigecycline | Escherichia coli | China | 2021 | PRJNA663118|PRJNA576562 | - |
| tet_A | Reslit | 1 | tetracycline | Salmonella enterica | The Gambia | 2022 | SAMEA6991082|SAMEA6991083|SAMEA6991084|SAMEA6991085|SAMEA6991086|SAMEA6991087|SAMEA6991088|SAMEA6991089|SAMEA6991090|SAMEA6991091|SAMEA6991092|SAMEA6991093|SAMEA6991094|SAMEA6991095|SAMEA6991096|SAMEA6991097|SAMEA6991098|SAMEA6991099|SAMEA6991100|SAMEA6991101|SAMEA6991102|SAMEA6991103|SAMEA6991104|SAMEA6991105|SAMEA6991106|SAMEA6991107|SAMEA6991108|SAMEA6991109|SAMEA6991110|SAMEA6991111|SAMEA6991112|SAMEA6991113|SAMEA6991114|SAMEA6991115|SAMEA6991116|SAMEA6991117|SAMEA6991118|SAMEA6991119|SAMEA6991120|SAMEA6991121|SAMEA6991122|SAMEA6991123|SAMEA6991124|SAMEA6991125|SAMEA6991126|SAMEA6991127|SAMEA6991128|SAMEA6991129|SAMEA6991130|SAMEA6991131|SAMEA6991132|SAMEA6991133|SAMEA6991134|SAMEA6991135|SAMEA6991136|SAMEA6991137|SAMEA6991138|SAMEA6991139|SAMEA6991140|SAMEA6991141|SAMEA6991142|SAMEA6991143|SAMEA6991144|SAMEA6991145|SAMEA6991146|SAMEA6991147|SAMEA6991148|SAMEA6991149|SAMEA6991150|SAMEA6991151|SAMEA6991152|SAMEA6991153|SAMEA6991154|SAMEA6991155|SAMEA6991156|SAMEA6991157|SAMEA6991158|SAMEA6991159|SAMEA6991160|SAMEA6991161|SAMEA6991162|SAMEA6991163|SAMEA6991164|SAMEA6991165|SAMEA6991166|SAMEA6991167|SAMEA6991168|SAMEA6991169|SAMEA6991170|SAMEA6991171|SAMEA6991172|SAMEA6991173|SAMEA6991174|SAMEA6991175|SAMEA6991176|SAMEA6991177|SAMEA6991178|SAMEA6991179|SAMEA6991180 | - |
| tetA-like | Reslit | 1 | tetracycline | Citrobacter freundii +2 | Europe|Portugal | 2022 | CP039857|KF954760|MN180807|KX946994|HE616889|JAJBJE000000000|JAJDEY000000000|JAKKZG00000000 | - |
| tet -A-v2 | Reslit | 1 | tetracycline | Escherichia coli | Southeast Nigeria | 2022 | PRJEB43719 | - |
| tet -A | Reslit | 1 | tetracycline | Escherichia coli | Southeast Nigeria | 2022 | PRJEB43719 | - |
| tetA-02 | Reslit | 1 | tetracycline | Aeromonas veronii | China | 2023 | - | - |
| tet(A)-tetR(A) | Reslit | 1 | tetracycline | Escherichia coli | China | 2024 | CP095083|CP095084|CP095085 | - |
| tet-A | Reslit | 2 | tetracycline | Escherichia coli +1 | Gaza Strip, Sri Lanka | 2024, 2025 | PRJNA984638 | - |
| tet (A)-v1 | Reslit | 1 | tigecycline | Klebsiella pneumoniae | China | 2025 | - | - |
| tet ( A ) | Reslit | 1 | tetracycline | Klebsiella pneumoniae | East Africa|Tanzania|Uganda | 2025 | PRJNA951629 | - |
| Tet | Reslit | 1 | tetracycline | Pseudomonas aeruginosa +5 | - | 2025 | - | - |
| tet(A) | Card DatabaseResFinder Database | 3 | TETRACYCLINE, DOXYCYCLINE +1 | Shigella sonnei +1 | - | 1983 | AF534183.1 | AAN06707.1 |
In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936).
The study characterizes the in vitro and in vivo antibacterial activities of TBG-MINO, a novel glycylcycline, against various tetracycline-resistant strains, including those with tet(A), tet(B), tet(C), tet(D), tet(K), and tet(M) resistance determinants.
Growth and development of tetracycline-resistant Chlamydia suis.
The study characterizes tetracycline-resistant Chlamydia suis strains R19 and R27, showing their ability to grow in high concentrations of tetracycline and form aberrant reticulate bodies.
Development, validation, and application of PCR primers for detection of tetracycline efflux genes of gram-negative bacteria.
The study developed and validated PCR primers for detecting tetracycline efflux genes in gram-negative bacteria, identifying multiple tet genes in swine feed, feces, and groundwater, highlighting the spread of tetracycline resistance in agricultural environments.
A multiresistant clone of Shiga toxin-producing Escherichia coli O118:[H16] is spread in cattle and humans over different European countries.
Structural analysis of the tetracycline resistance gene region of a small multiresistance plasmid from uropathogenic Escherichia coli isolated in Nigeria.
Antibiotic multiresistance plasmid pRSB101 isolated from a wastewater treatment plant is related to plasmids residing in phytopathogenic bacteria and carries eight different resistance determinants including a multidrug transport system.
Cats as a risk for transmission of antimicrobial drug-resistant Salmonella.
The study identified several antimicrobial resistance genes in Salmonella isolates from cats, including blaTEM, cat, sul2, tet(A), and dfrA1, which confer resistance to ampicillin, chloramphenicol, sulfonamides, tetracycline, and trimethoprim, respectively.
Distribution of tetracycline resistance genes in genotypically related and unrelated multiresistant Acinetobacter baumannii strains from different European hospitals.
The study identified tet(A), tet(B), and tet(M) as tetracycline resistance genes in Acinetobacter baumannii strains, with tet(B) additionally conferring resistance to minocycline. The efflux gene adeB was present in all strains regardless of tet gene status.
Development and Application of Real-Time PCR Assays for Quantification of Genes Encoding Tetracycline Resistance
The study developed and validated real-time PCR assays to quantify ten major classes of tetracycline resistance genes (tet) in microbiome samples, revealing significant differences in tet gene abundance between bovine and swine manures, with swine manures showing higher levels. Composting significantly reduced tet gene abundance.
Class 1 integrons and tetracycline resistance genes in alcaligenes, arthrobacter, and Pseudomonas spp. isolated from pigsties and manured soil.
The study identifies several tetracycline resistance genes (tet(A), tet(C), tet(33)) and gene cassettes (aadA1, aadA2, aadA9, aadA11, dfrA1, dfrB2a) associated with class 1 integrons in various bacterial species isolated from pigsties and manured soil.
Tetracycline Resistance in Escherichia coli and Persistence in the Infantile Colonic Microbiota.
The study identified tet(A) and tet(B) genes as the primary tetracycline resistance mechanisms in commensal E. coli strains from Swedish infants, highlighting their prevalence and association with other antibiotic resistances.
Multidrug-resistant commensal Escherichia coli in children, Peru and Bolivia.
The study identified multiple multidrug-resistant commensal E. coli isolates in children from Peru and Bolivia, highlighting the prevalence of resistance genes such as blaTEM, tet(A), tet(B), dfrA8, sul1, sul2, and catI.
A variation of the translation attenuation model can explain the inducible regulation of the pBC16 tetracycline resistance gene in Bacillus subtilis.
The study identifies the pBC16 tetracycline resistance gene (tet) in Bacillus subtilis and demonstrates that its regulation follows a variation of the translation attenuation model, where the wild-type gene confers resistance without requiring mutations.
Use of the lambda Red recombinase system to produce recombinant prophages carrying antibiotic resistance genes.
The study demonstrates the successful incorporation of the cat and tet genes into the stx2 gene of prophages using the lambda Red recombinase system, resulting in the production of recombinant prophages that confer resistance to chloramphenicol and tetracycline.
Antimicrobial-resistant enteric bacteria from dairy cattle.
The study identified tet(B) and tet(A) as the primary tetracycline resistance determinants in tetracycline-resistant E. coli isolates from dairy cattle.
Population structure and resistance genes in antibiotic-resistant bacteria from a remote community with minimal antibiotic exposure.
The study identified various acquired antibiotic resistance genes in commensal E. coli isolates from a remote community with minimal antibiotic exposure, including blaTEM, catI, cmlA6, tet(A), tet(B), dfrA1, dfrA7, dfrA8, dfrA17, sul1, sul2, aphA1, aadA1, aadA2, aadA5, aadB, and sat-1. These genes were found to be similar to those seen in antibiotic-exposed settings, indicating the dissemination of resistant bacteria and resistance genes from such environments.
Evaluating the effects of chlortetracycline on the proliferation of antibiotic-resistant bacteria in a simulated river water ecosystem.
The study found that high concentrations of chlortetracycline (CTC) selected for increased tetracycline resistance in aerobic bacterial populations, with a greater diversity of tet resistance genes detected in the high-CTC chemostat compared to low-CTC and control chemostats.
Impact of feed supplementation with antimicrobial agents on growth performance of broiler chickens, Clostridium perfringens and enterococcus counts, and antibiotic resistance phenotypes and distribution of antimicrobial resistance determinants in Escherichia coli isolates.
The study identified several AMR genes in E. coli isolates from broiler chickens, including blaTEM, blaSHV, aadA, tet(A), tet(B), sulI, sulII, and floR, which conferred resistance to various antibiotics such as amoxicillin, tetracycline, sulfonamides, and chloramphenicol.
Prevalence of qnr genes among extended-spectrum beta-lactamase-producing enterobacterial isolates in Barcelona, Spain.
Complete DNA sequence and analysis of the transferable multiple-drug resistance plasmids (R Plasmids) from Photobacterium damselae subsp. piscicida isolates collected in Japan and the United States.
The study characterizes multiple-drug resistance plasmids from Photobacterium damselae subsp. piscicida, identifying genes conferring resistance to kanamycin, chloramphenicol, tetracycline, sulfonamide, and trimethoprim.
Longitudinal study of antimicrobial resistance among Escherichia coli isolates from integrated multisite cohorts of humans and swine.
The study identified various AMR genes in E. coli isolates from humans and swine, highlighting differences in resistance profiles between the two hosts. Key genes included beta-lactamases (blaCTX-M, blaTEM, blaSHV), aminoglycoside modifying enzymes (aac(6')-Ib, aadA), tetracycline resistance (tet(A)), quinolone resistance (qnrS1), macrolide resistance (erm(B)), and efflux pumps (mexAB-OprM).
Novel insertion sequence- and transposon-mediated genetic rearrangements in genomic island SGI1 of Salmonella enterica serovar Kentucky.
Diversity and distribution of commensal fecal Escherichia coli bacteria in beef cattle administered selected subtherapeutic antimicrobials in a feedlot setting.
The study identified bla TEM1, tet (A), and sul2 as prevalent resistance genes in commensal E. coli from beef cattle, highlighting the impact of antimicrobial use on resistance dissemination.
Complete nucleotide sequence of pKP96, a 67 850 bp multiresistance plasmid encoding qnrA1, aac(6')-Ib-cr and blaCTX-M-24 from Klebsiella pneumoniae.
Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophage.
The study identifies multiple AMR genes and mutations in a multidrug-resistant Staphylococcus aureus strain, including mecA, aadD, bleO, ermC, tet, and a chromosomal mutation in gyrA, contributing to resistance against beta-lactams, aminoglycosides, macrolides, tetracyclines, and fluoroquinolones.
Efflux-mediated drug resistance in bacteria: an update.
The paper provides an updated overview of drug efflux pumps in bacteria, focusing on their structure, mechanisms, and roles in multidrug resistance. It highlights the importance of RND, MFS, MATE, SMR, and ABC transporters in efflux-mediated resistance.
Antimicrobial resistances do not affect colonization parameters of intestinal E. coli in a small piglet group.
The study identified various AMR genes in commensal E. coli from pigs, including blaTEM, catA1, aph(3')-Ia, aadA, strA/strB, tet(A), tet(B), sul1, sul2, and sul3. These genes conferred resistance to antibiotics such as ampicillin, chloramphenicol, kanamycin, neomycin, streptomycin, spectinomycin, tetracycline, and sulfamethoxazole. However, the presence of these resistance genes did not provide a significant colonization advantage or disadvantage in the pig intestine.
Tracking acquired antibiotic resistance in commensal bacteria of Galápagos land iguanas: no man, no resistance.
Two E. coli isolates from Galápagos land iguanas were found to carry acquired resistance genes, including tet(B), aadB, aacA4, cat1, tet(A), blaTEM, and sul1, indicating human-related contamination in a remote ecosystem.
Antibiotic resistance characteristics of environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river.
The study identified multiple tetracycline resistance genes (tet(A), tet(W), tet(C), tet(J), tet(L), tet(D), tet(Y), and tet(K)) in environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river, highlighting the widespread dissemination of these genes in aquatic environments exposed to high levels of antibiotic residues.
Distribution and characterization of ampicillin- and tetracycline-resistant Escherichia coli from feedlot cattle fed subtherapeutic antimicrobials.
The study identified the tetracycline resistance gene tet(B) and the ampicillin resistance gene tem1-like in Escherichia coli isolates from feedlot cattle. These genes were found to confer resistance to tetracycline and ampicillin, respectively.
Characterization of multidrug-resistant Escherichia coli isolates from animals presenting at a university veterinary hospital.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from animals, including bla TEM, bla CTX-M-2, bla CMY-2, strA-strB, aadA, aphA1, aadB, cat, floR, sul1, sul2, tet(A), and tet(B). These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, sulfonamides, and tetracyclines.
Molecular characterization of multidrug-resistant Escherichia coli isolates from Irish cattle farms.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from Irish cattle farms, including strA-strB, aphA1, aadA, aadB, blaTEM, sul2, tet(A), and tet(B). These genes were associated with resistance to streptomycin, neomycin, kanamycin, spectinomycin, ampicillin, amoxicillin-clavulanic acid, sulfonamides, and tetracycline.
QRDR mutations, efflux system & antimicrobial resistance genes in enterotoxigenic Escherichia coli isolated from an outbreak of diarrhoea in Ahmedabad, India.
The study identified QRDR mutations in gyrA and parC, as well as the aac(6')-Ib-cr gene, class 1 and class 2 integrons, and various resistance genes including blaTEM-1, catA1, dfrA1, dfrA17, aadA1, aadA5, strA, tet, and aphA1-Ia in ETEC strains, contributing to multidrug resistance.
Phenotypic and genotypic characterization of Salmonella enterica recovered from poultry meat in Tunisia and identification of new genetic traits.
The study identified various AMR genes in Salmonella enterica isolates from poultry meat in Tunisia, including blaTEM, aadA1, aadA2, dfrA1, sul1, sul2, sul3, strA-strB, cmlA, and tet(A). These genes contribute to resistance against multiple antibiotics such as ampicillin, sulfonamides, streptomycin, trimethoprim, chloramphenicol, and tetracycline.
Mainstreams of horizontal gene exchange in enterobacteria: consideration of the outbreak of enterohemorrhagic E. coli O104:H4 in Germany in 2011.
The study identified various genomic islands (GIs) in enterobacteria, including those carrying antibiotic resistance genes such as beta-lactamase (bla), tetracycline efflux protein (tet), and mercury resistance operon (mer). These GIs were found to be horizontally transferred and contributed to the virulence and resistance profiles of the strains analyzed.
Multidrug-resistant Acinetobacter spp.: increasingly problematic nosocomial pathogens.
The study characterizes multiple AMR genes and mutations in Acinetobacter spp., including OXA-type carbapenemases, aminoglycoside-modifying enzymes, and fluoroquinolone resistance genes, highlighting the increasing challenge of multidrug-resistant Acinetobacter infections.
Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic.
The study characterizes several tetracycline resistance genes, including tet(M), tet(K), tet(B), tet(A), and tet(X), demonstrating their roles in conferring resistance to tetracycline and related antibiotics.
Antimicrobial resistance in Escherichia coli isolates from raccoons (Procyon lotor) in Southern Ontario, Canada.
The study identified the presence of antimicrobial resistance genes such as bla CMY-2, tet(A), and tet(B) in Escherichia coli isolates from raccoons in Southern Ontario, Canada. These genes confer resistance to ceftiofur and tetracycline.
Tetracycline resistant V. cholerae O1 biotype El Tor serotype Ogawa with classical ctxB from a recent cholera outbreak in Orissa, Eastern India.
The study reports the emergence of tetracycline-resistant Vibrio cholerae O1 biotype El Tor serotype Ogawa with classical ctxB from a recent cholera outbreak in Orissa, India. The isolates showed resistance to tetracycline through an efflux-mediated mechanism.
Characteristics of plasmids in multi-drug-resistant Enterobacteriaceae isolated during prospective surveillance of a newly opened hospital in Iraq.
The study identified various plasmid-borne antimicrobial resistance genes in multi-drug-resistant Enterobacteriaceae isolates from a newly opened hospital in Iraq, including aminoglycoside, beta-lactam, sulfamethoxazole/trime-thoprim, tetracycline, and chloramphenicol resistance genes.
A novel approach to associate genes and mutations with drug resistance phenotypes by comparative analysis of fully sequenced bacterial strains
The study identified several AMR genes and mutations associated with drug resistance in S. aureus, including blaZ, mecA, tet, tetM, aacA-aphD, and mutations in rpsL, rpsJ, grlA, and gyrA.
Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan.
The study identified tetracycline resistance genes tet(A) and tet(B) in multidrug-resistant Escherichia coli isolates from both US and Afghanistan-based military personnel.
Chronological Change of Resistance to β-Lactams in Salmonella enterica serovar Infantis Isolated from Broilers in Japan.
The study identified the emergence of Salmonella enterica serovar Infantis isolates carrying blaTEM-52, blaTEM-20, blaCTX-M-25, and blaCMY-2 genes, which confer resistance to extended-spectrum cephalosporins and other beta-lactams. Additionally, non-beta-lactam resistance genes such as aadA1, sul1, tet(A), and aphA1-Iab were prevalent.
Escherichia coli tetracycline efflux determinants in relation to tetracycline residues in chicken
The study identified tet(A) and tet(B) efflux genes in Escherichia coli isolates from chicken colons, which confer resistance to tetracycline.
Impact of manure fertilization on the abundance of antibiotic-resistant bacteria and frequency of detection of antibiotic resistance genes in soil and on vegetables at harvest.
The study identified several antibiotic resistance genes in soil and on vegetables, including genes conferring resistance to tetracycline, aminoglycosides, erythromycin, sulfamethoxazole, and beta-lactams. The presence of these genes was influenced by manure fertilization, with certain genes more frequently detected in manured soils.
Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India. J. Med. Microbiol.
The study identified several AMR genes including blaTEM-1, aac(6')-Ib, and tet(A) in multidrug-resistant Shigella species isolated from shigellosis cases in India.
Antimicrobial resistance determinants in Acinetobacter baumannii isolates taken from military treatment facilities.
The study identified multiple antimicrobial resistance genes in Acinetobacter baumannii isolates from military treatment facilities, including bla OXA-51-like, bla OXA-23, bla GES-11, aac(6')-Ib, aacC1, aadB, aphA6, and others, highlighting the complex resistome of these isolates.
Effects of ceftiofur and chlortetracycline treatment strategies on antimicrobial susceptibility and on tet(A), tet(B), and bla CMY-2 resistance genes among E. coli isolated from the feces of feedlot cattle.
The study identified tet(A), tet(B), and bla CMY-2 as key resistance genes in E. coli isolates from feedlot cattle, with bla CMY-2 associated with high multidrug resistance. CTC treatment influenced the selection of tetracycline resistance genes, favoring tet(B) over tet(A).
Diversity of plasmids encoding resistance and virulence functions in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variant 4,[5],12:i:- strains circulating in Europe.
The study identifies various AMR genes in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variant 4,[5],12:i:- strains, including aac(3)-IV, bla TEM-1, cmlA1, aadA1, aadA2, strA, sul1, sul2, sul3, tet(A), tet(B), and dfrA12, which confer resistance to multiple antibiotics.
Shifts in geographic distribution and antimicrobial resistance during a prolonged typhoid fever outbreak--Bundibugyo and Kasese Districts, Uganda, 2009-2011.
The study reports a high prevalence of multidrug-resistant (MDR) Salmonella Typhi isolates during a prolonged typhoid fever outbreak in Uganda, with 83% of 18 isolates being MDR. It also notes an increase in antimicrobial resistance compared to 2009 isolates.
Characterization of microbiota composition and presence of selected antibiotic resistance genes in carriage water of ornamental fish.
The study identified several antibiotic resistance genes including sul1, tet(A), strA, aadA, cat, tet(G), and sul2 in the microbiota of ornamental fish carriage water. These genes were found to be prevalent and associated with various bacterial families.
Genomic Analysis of Antimicrobial Resistance in Clinical Isolates of Escherichia coli
The study identified various AMR genes in ExPEC E. coli strains, including beta-lactamases (blaCTX-M, blaSHV, blaTEM), quinolone resistance genes (qnrS1), aminoglycoside modifying enzymes (aac(6')-Ib, aadA), tetracycline resistance genes (tet(A)), macrolide resistance genes (mph(A), erm(B), mef(A)), and others. These genes were associated with resistance to multiple antibiotics.
Tetracycline Resistance Genes in Campylobacter jejuni and C. coli Isolated From Poultry Carcasses.
The study identified the presence of tet(O) and tet(A) genes in Campylobacter isolates from poultry carcasses in Iran, highlighting the high prevalence of tetracycline resistance in these isolates.
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.
The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.
The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.
Detection of tetracycline resistance genes in bacteria isolated from fish farms using polymerase chain reaction.
The study identified tetracycline resistance genes tet(A), tet(M), and tet(S) in bacterial isolates from Iranian fish farms, with tet(S) being the most prevalent.
Transferable antibiotic resistance plasmids from biogas plant digestates often belong to the IncP-1ε subgroup.
The study identified IncP-1ε plasmids carrying genes such as tet(A), sul1, qacEΔ1, intI1, and aadA1, which confer resistance to tetracycline, sulfadiazine, quaternary ammonium compounds, and streptomycin.
Molecular characterization of a multidrug resistance IncF plasmid from the globally disseminated Escherichia coli ST131 clone.
The study identifies multiple antibiotic resistance genes on the IncF plasmid pEC958 from E. coli ST131, including blaCTX-M-15, aac(6')-Ib-cr, blaOXA-1, catB4, mph(A), dfrA17, aadA5, sulI, and tet(A). These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, macrolides, trimethoprim, sulfamethoxazole, and tetracycline.
Bacteriophages Isolated from Chicken Meat and the Horizontal Transfer of Antimicrobial Resistance Genes.
The study identified several antimicrobial resistance genes, including tet(A), aphA1, blaTEM, and floR, which were transduced by phages isolated from chicken meat, highlighting the role of bacteriophages in the horizontal transfer of antimicrobial resistance.
Healthcare- and Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) and Fatal Pneumonia with Pediatric Deaths in Krasnoyarsk, Siberian Russia: Unique MRSA's Multiple Virulence Factors, Genome, and Stepwise Evolution.
The study identifies multiple antimicrobial resistance genes in MRSA strains from Krasnoyarsk, Siberian Russia, including mecA, blaZ, ermA, ermC, cat, aacA-aphD, aadD, tet, spc, ble, qacA, cad, and mer, which confer resistance to various antibiotics such as methicillin, ampicillin, erythromycin, clindamycin, chloramphenicol, gentamicin, kanamycin, tetracycline, spectinomycin, bleomycin, quaternary ammonium compounds, cadmium, and mercury.
Prevalence of Antimicrobial Resistance and Transfer of Tetracycline Resistance Genes in Escherichia coli Isolates from Beef Cattle.
The study identified tet(A), tet(B), and tet(C) as the predominant tetracycline resistance genes in E. coli isolates from beef cattle, with tet(B) showing higher MIC values compared to tet(A).
Prevalence of tetracycline resistance genes among multi-drug resistant bacteria from selected water distribution systems in southwestern Nigeria.
The study identified the prevalence of tetracycline resistance genes, particularly tet(A), among multi-drug resistant bacteria in water distribution systems in southwestern Nigeria, highlighting the potential for horizontal gene transfer.
Sampling and Pooling Methods for Capturing Herd Level Antibiotic Resistance in Swine Feces using qPCR and CFU Approaches.
The study identified several antibiotic resistance genes in swine fecal samples using qPCR, including tetracycline resistance genes (tet(A), tet(B), tet(C), tet(M), tet(O), tet(W)), erythromycin resistance genes (ermB, ermF), sulfonamide resistance genes (sulI, sulII), beta-lactam resistance genes (blaCTX-M-1 group, blaCMY-2, blaSHV family), and glycopeptide resistance gene (vanA).
Comparative analysis of antimicrobial resistance in enterotoxigenic Escherichia coli isolates from two paediatric cohort studies in Lima, Peru.
The study identified several AMR genes in ETEC isolates from Peruvian children, including bla TEM-like for ampicillin resistance, sul2 for sulfamethoxazole resistance, tet(A) and tet(B) for tetracycline resistance, and mph(A) for azithromycin resistance.
Antimicrobial Susceptibility of Bordetella bronchiseptica Isolates from Swine and Companion Animals and Detection of Resistance Genes.
The study identified several AMR genes in Bordetella bronchiseptica isolates, including blaBOR-1, blaOXA, strA, strB, sul1, sul2, dfrA7, and tet(A). These genes confer resistance to various antibiotics such as ampicillin, streptomycin, trimethoprim/sulfamethoxazole, and tetracycline.
Molecular characterization of selected multidrug resistant Pseudomonas from water distribution systems in southwestern Nigeria.
The study identified multiple antibiotic resistance genes in multidrug-resistant Pseudomonas isolates from water distribution systems in southwestern Nigeria, including tet(A), sul1, blaTEM, aph(3")c, and ant(3")b.
The controversial nature of the Weissella genus: technological and functional aspects versus whole genome analysis-based pathogenic potential for their application in food and health.
The study identified several antibiotic resistance genes in Weissella species, including fosB, mdt-fosB, mrp, vanZ, sul, tet, and drrC, which confer resistance to fosfomycin, methicillin, teicoplanin, sulfonamide, tetracycline, and daunorubicin respectively.
High-Specificity Targeted Functional Profiling in Microbial Communities with ShortBRED.
ShortBRED was developed to improve the accuracy and efficiency of profiling antibiotic resistance (AR) protein families in metagenomic data. The study identified tetracycline-resistant ribosomal protection proteins and Class A beta-lactamases as the most widely distributed resistance mechanisms globally.
Escherichia coli Population Structure and Antibiotic Resistance at a Buffalo/Cattle Interface in Southern Africa.
The study identified tetracycline, trimethoprim, and amoxicillin resistance genes (tet, dfrA, and blaTEM-1) in E. coli strains from buffalo and cattle populations in Zimbabwe, highlighting the role of human-animal interfaces in the dissemination of antibiotic resistance.
Emergence of a Clonal Lineage of Multidrug-Resistant ESBL-Producing Salmonella Infantis Transmitted from Broilers and Broiler Meat to Humans in Italy between 2011 and 2014.
The study identifies the emergence of a multidrug-resistant ESBL-producing Salmonella Infantis clone transmitting from broilers and broiler meat to humans in Italy, harboring the bla CTX-M-1 and bla CTX-M-65 genes, along with resistance genes tet(A), sul1, dfrA1, and dfrA14.
Draft Genome Sequence of Proteus mirabilis NO-051/03, Representative of a Multidrug-Resistant Clone Spreading in Europe and Expressing the CMY-16 AmpC-Type β-Lactamase.
The draft genome sequence of Proteus mirabilis NO-051/03 reveals the presence of multiple acquired resistance genes, including blaCMY-16 and blaTEM-1b, which confer resistance to β-lactams, as well as genes for resistance to aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, and sulfonamides. Additionally, mutations in gyrA, gyrB, and parC contribute to fluoroquinolone resistance.
Prevalence of plasmid-mediated multidrug resistance determinants in fluoroquinolone-resistant bacteria isolated from sewage and surface water.
The study identified several plasmid-mediated resistance genes in fluoroquinolone-resistant bacteria, including aac(6')-Ib-cr, qnrS, qnrD, oqx A, blaTEM, blaOXA, blaCTX-M, blaSHV, tet(A), tet(K), tet(L), and tet(S). These genes were found to confer resistance to fluoroquinolones, beta-lactams, and tetracyclines.
Carriage of Extended-Spectrum Beta-Lactamase-Plasmids Does Not Reduce Fitness but Enhances Virulence in Some Strains of Pandemic E. coli Lineages.
The study found that ESBL-plasmid carriage does not reduce fitness but enhances virulence in some strains of pandemic E. coli lineages. It identified several AMR genes on the ESBL-plasmids, including beta-lactamases (blaCTX-M-15, blaCTX-M-27, blaCTX-M-14), tetracycline resistance genes (tetA, tetR), aminoglycoside resistance genes (aadA, aac(6')-Ib-cr), chloramphenicol resistance gene (catB4), sulfonamide resistance gene (sul2), streptomycin resistance genes (strA, strB), dihydrofolate reductase genes (dhfrVII, dfrA17), and aminoglycoside phosphotransferase gene (aph(3')-Ia). Non-antibiotic resistance genes such as finO, traT, icc, yfaX, yihA, and hha were also identified.
Microarray Evaluation of Antimicrobial Resistance and Virulence of Escherichia coli Isolates from Portuguese Poultry.
The study identified several antimicrobial resistance genes in Escherichia coli isolates from Portuguese poultry, including tet(A), blaTEM, sul1, and blaCTX-M. High levels of resistance to tetracycline, ampicillin, and cefotaxime were observed.
IncF Plasmids Are Commonly Carried by Antibiotic Resistant Escherichia coli Isolated from Drinking Water Sources in Northern Tanzania.
The study identified several antibiotic resistance genes, including bla TEM-1, bla CTX-M, tet(A), and tet(B), carried by IncF plasmids in multidrug-resistant E. coli isolates from Tanzanian water sources. These genes contribute to resistance against ampicillin, ceftazidime, and tetracycline.
Antibiotic Resistance, Core-Genome and Protein Expression in IncHI1 Plasmids in Salmonella Typhimurium.
The study identified multiple antibiotic resistance genes in IncHI1 plasmids of Salmonella Typhimurium, including tet(B), tet(A), blaTEM, strA, strB, sul2, aadA, dfrA, catA1, aphA1a, and aad(3)IId, which confer resistance to various antibiotics such as tetracycline, beta-lactam, streptomycin, sulfonamide, aminoglycoside, chloramphenicol, and trimethoprim.
Detection of Antibiotic Resistance Genes in Source and Drinking Water Samples from a First Nations Community in Canada.
The study identified several antibiotic resistance genes, including ampC, tet(A), and mecA, in water samples from a First Nations community in Canada, highlighting concerns about water quality and potential health risks.
SSTAR, a Stand-Alone Easy-To-Use Antimicrobial Resistance Gene Predictor.
The study presents SSTAR, a software tool for identifying antimicrobial resistance (AR) genes from whole-genome sequencing data. It detects known AR genes and potential new variants, including truncated forms. The tool was applied to analyze resistance genes in Klebsiella pneumoniae ST437 and Escherichia coli ST44, revealing various beta-lactamases, aminoglycoside resistance genes, and porin mutations contributing to resistance.
Complete Genome Sequence of a Novel Bacillus sp. VT 712 Strain Isolated from the Duodenum of a Patient with Intestinal Cancer.
The complete genome sequence of Bacillus sp. VT 712 reveals several antibiotic resistance genes, including those encoding resistance to vancomycin (vanZ, vanB, vanW), tetracycline (tet(A)), fosfomycin (fosB), multidrug resistance efflux pumps (including acrB), beta-lactamases, and the quaternary ammonium compound resistance protein sugE.
Antimicrobial resistance of Campylobacter isolates from small scale and backyard chicken in Kenya.
High levels of resistance to ciprofloxacin, nalidixic acid, and tetracycline were observed in Campylobacter isolates from Kenyan chicken, with specific genes (gyrA, tet(O), and tet(A)) identified as contributing to resistance.
Draft Genome Sequence of Salmonella enterica subsp. enterica Serovar Bardo Strain CRJJGF_00099 (Phylum Gammaproteobacteria).
The study reports the identification of several AMR genes in a multidrug-resistant Salmonella enterica subsp. enterica serovar Bardo strain, including strA, strB, cmy-94, floR, sulII, tet(A), and aac6-Iy.
Comparative Genome Analysis of Extended-Spectrum-β-Lactamase-Producing Escherichia coli Sequence Type 131 Strains from Nepal and Japan.
The study identified multiple AMR genes, including blaCTX-M-15, blaOXA-1, aac(6')-Ib-cr, tet(A), mphA, strA, strB, aadA5, sul1, sul2, dfrA12, dfrA17, catA1, and catB3, in ESBL-producing E. coli ST131 isolates from Nepal and Japan. These genes conferred resistance to various antibiotics, including β-lactams, aminoglycosides, tetracyclines, macrolides, sulfonamides, and chloramphenicol.
Characterisation of Commensal Escherichia coli Isolated from Apparently Healthy Cattle and Their Attendants in Tanzania.
The study identified several antimicrobial resistance genes in commensal E. coli isolates from cattle and their attendants in Tanzania, including blaTEM-1B, sul1, sul2, and tet(A). These genes conferred resistance to beta-lactams, sulfamethoxazole-trimethoprim, and tetracycline, respectively.
Whole-Genome Analysis of Antimicrobial-Resistant and Extraintestinal Pathogenic Escherichia coli in River Water.
The study identified numerous antimicrobial resistance genes in Escherichia coli isolates from river water, highlighting the presence of multidrug-resistant and extraintestinal pathogenic strains. Key resistance genes included blaTEM-1, aac(3)-IId, qnrB7, and others.
Antibacterial Activities and Possible Modes of Action of Acacia nilotica (L.) Del. against Multidrug-Resistant Escherichia coli and Salmonella.
The study identified beta-lactam resistance gene bla CMY and tetracycline resistance genes tet (A) and tet (B) in multidrug-resistant E. coli and Salmonella isolates.
Antimicrobial and antioxidant activities of Saccharomyces cerevisiae IFST062013, a potential probiotic.
The study identifies Saccharomyces cerevisiae IFST 062013 as a potential probiotic with resistance to tetracycline, ampicillin, gentamicin, penicillin, polymyxin B, and nalidixic acid.
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
Marine Bivalve Mollusks As Possible Indicators of Multidrug-Resistant Escherichia coli and Other Species of the Enterobacteriaceae Family.
The study identified multiple AMR genes in E. coli isolates from marine bivalves, including bla TEM-1, bla CTX-M-14, bla CTX-M-15, and various aminoglycoside, trimethoprim, sulfonamide, tetracycline, chloramphenicol, quinolone, and macrolide resistance genes. These findings highlight the potential risk of MDR Enterobacteriaceae in marine environments.
Carbapenem-resistance and pathogenicity of bovine Acinetobacter indicus-like isolates.
The study identifies carbapenem-resistant Acinetobacter indicus-like isolates from cattle carrying the blaOXA-23 gene, along with various other AMR genes such as aac(3)-IIa, strA/B, aph(3')-Ic, sul2, floR, tet(A), tet(Y), aadA1, aadB, sul1, and tet(X).
Assessment of Tetracyclines Residues and Tetracycline Resistant Bacteria in Conventional and Organic Baby Foods.
The study identified and quantified the presence of tet(A) and tet(B) genes in conventional and organic baby foods, indicating the widespread distribution of tetracycline-resistant bacteria in both types of products.
Whole-Genome Sequencing of Drug-Resistant Salmonella enterica Isolates from Dairy Cattle and Humans in New York and Washington States Reveals Source and Geographic Associations.
The study identified several AMR genes and mutations in Salmonella enterica isolates from dairy cattle and humans in New York and Washington States, highlighting the role of geographic and source-specific factors in AMR dissemination.
Day-to-Day Dynamics of Commensal Escherichia coli in Zimbabwean Cows Evidence Temporal Fluctuations within a Host-Specific Population Structure.
The study identified a few antibiotic-resistant E. coli clones in Zimbabwean cows, including resistance to tetracycline, penicillins, and trimethoprim, but these were rare and subdominant.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
Genomic Analysis of Multidrug-Resistant Escherichia coli from North Carolina Community Hospitals: Ongoing Circulation of CTX-M-Producing ST131-H30Rx and ST131-H30R1 Strains.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from North Carolina community hospitals, including bla CTX-M-15, bla CTX-M-14, aac(6′)-Ib-cr, qnrS1, and mutations in gyrA, parC, and parE that confer resistance to various antibiotics.
A Functional Metagenomic Analysis of Tetracycline Resistance in Cheese Bacteria.
The study identified four tetracycline resistance genes (tet(A), tet(L), tet(M), and tet(S)) in cheese bacteria using functional metagenomics.
Horizontal Dissemination of Antimicrobial Resistance Determinants in Multiple Salmonella Serotypes following Isolation from the Commercial Swine Operation Environment after Manure Application.
The study identified various antimicrobial resistance genes, including bla_CMY-2, bla_TEM, aadA2, tet(A), tet(B), sul1, and sul2, in multiple Salmonella serotypes isolated from swine farm environments. These genes were found on plasmids and contributed to resistance against beta-lactams, aminoglycosides, tetracyclines, and sulfonamides.
Molecular determination of antimicrobial resistance in Escherichia coli isolated from raw meat in Addis Ababa and Bishoftu, Ethiopia.
The study identified several AMR genes in E. coli isolates from raw meat, including blaCMY, tet(A), and sul1, which confer resistance to beta-lactams, tetracyclines, and sulfonamides, respectively.
pirAB(vp)-Bearing Vibrio parahaemolyticus and Vibrio campbellii Pathogens Isolated from the Same AHPND-Affected Pond Possess Highly Similar Pathogenic Plasmids.
The study identifies antibiotic resistance genes in Vibrio parahaemolyticus and Vibrio campbellii strains isolated from an AHPND-affected pond, highlighting the presence of tetracycline, sulfonamide, streptomycin, and florfenicol resistance mechanisms.
Public health surveillance in the UK revolutionises our understanding of the invasive Salmonella Typhimurium epidemic in Africa.
The study identified the presence of the blaCTX-M-15 gene in a UK-isolated lineage 2 strain of Salmonella Typhimurium, highlighting the potential for spread of extended-spectrum beta-lactamase resistance.
Exploring the Genome and Phenotype of Multi-Drug Resistant Klebsiella pneumoniae of Clinical Origin.
The study identified multiple antimicrobial resistance genes in 11 multidrug-resistant Klebsiella pneumoniae isolates, including ESBL genes (blaCTX-M-15, blaSHV-12, blaTEM-1B), fluoroquinolone resistance genes (oqxAB, qnrB), and others such as catA, catB, tet, sul, dfr, and fosA. These genes contribute to resistance against various antibiotics, highlighting the complex resistance profile of these isolates.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting.
The study identified various AMR genes and mutations in E. coli isolates from children with cystic fibrosis, cancer, and healthy controls, highlighting differences in resistance profiles between groups.
MinION Nanopore Sequencing Enables Correlation between Resistome Phenotype and Genotype of Coliform Bacteria in Municipal Sewage.
The study identified the beta-lactamase gene blaTEM-171 and the tetracycline resistance gene tet(A) in the multidrug-resistant coliform strain COL1, which were validated through plasmid transformation and antibiotic susceptibility testing.
MinION Nanopore Sequencing Enables Correlation between Resistome Phenotype and Genotype of Coliform Bacteria in Municipal Sewage.
The study identified the beta-lactamase gene blaTEM-171 and the tetracycline resistance gene tet(A) in the multidrug-resistant coliform strain COL1, which were validated through plasmid transformation and antibiotic susceptibility testing.
The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.
The study explores the complex resistomes of Paenibacillaceae, revealing diverse antibiotic resistance mechanisms including intrinsic and acquired resistance genes such as aadD2, vanA, vanB, vanC, vanD, vanE, vanF, vanG, mcr, bla, tet, qnr, erm, mph, lnu, lsa, vat, vgb, cat, cfr, optrA, poxtA, sul, dfr, mexAB-OprM, acrAB-TolC, and oqxAB.
High Prevalence of CTX-M-15-Type ESBL-Producing E. coli from Migratory Avian Species in Pakistan.
The study identified a high prevalence of CTX-M-15-type ESBL-producing E. coli in migratory avian species in Pakistan, highlighting the role of wild birds as reservoirs of multidrug-resistant bacteria and the potential for horizontal gene transfer of resistance determinants.
Characterization of plasmids harboring blaCTX-M and blaCMY genes in E. coli from French broilers.
The study characterized blaCTX-M-1 and blaCMY-2 genes in E. coli isolates from French broilers, highlighting their roles in extended-spectrum cephalosporin resistance and the presence of virulence genes on blaCMY-2-containing plasmids.
Comparison of antimicrobial resistance genes in feedlots and urban wastewater.
The study identified various antimicrobial resistance genes in feedlots and urban wastewater, highlighting the prevalence of sulfonamide, tetracycline, macrolide, fluoroquinolone, and β-lactam resistance genes in different environments.
Functional Repertoire of Antibiotic Resistance Genes in Antibiotic Manufacturing Effluents and Receiving Freshwater Sediments.
The study identified numerous antibiotic resistance genes (ARGs) in antibiotic manufacturing effluents and receiving sediments, highlighting the presence of both known and potentially novel resistance mechanisms. Key findings include the discovery of macrolide resistance genes such as hflx, msr(e), mph(e), mph(g), and mef(c), as well as sulfonamide resistance genes sul1 and sul2, and beta-lactamase genes like bla ges-1, bla veb-9, and bla cm y-10. Additionally, trimethoprim resistance genes dfr14, dfra1, and dfr17 were identified.
Impact of Wastewater Treatment on the Prevalence of Integrons and the Genetic Diversity of Integron Gene Cassettes.
The study identified various antibiotic resistance genes within integron gene cassettes in wastewater treatment plants, including aadA1, aadA2, aadA5, blaOXA-1, blaOXA-10, blaOXA-101, blaOXA-129, blaOXA-21, blaOXA-28, catB8, dfrA14, erm, qacE2, sul1, tet, orfD, and orfA, which confer resistance to aminoglycosides, beta-lactams, chloramphenicol, trimethoprim, sulfonamides, tetracyclines, and quaternary ammonium compounds.
Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population.
The study identifies clinically relevant ESBL-producing K. pneumoniae ST307 and E. coli ST38 in an urban West African rat population, highlighting the presence of multidrug-resistant strains carrying various resistance genes such as blaCTX-M-15, blaCTX-M-14, blaCTX-M-9, and others.
Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population.
The study identifies clinically relevant ESBL-producing K. pneumoniae ST307 and E. coli ST38 in an urban West African rat population, highlighting the presence of multidrug-resistant strains carrying various resistance genes such as blaCTX-M-15, blaCTX-M-14, blaCTX-M-9, and others.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Prevalence, toxin gene profile, antibiotic resistance, and molecular characterization of Clostridium perfringens from diarrheic and non-diarrheic dogs in Korea.
The study identified tetracycline resistance in Clostridium perfringens isolates from diarrheic and non-diarrheic dogs in Korea, with 25.0% of isolates showing resistance to tetracycline.
Impact of human-associated Escherichia coli clonal groups in Antarctic pinnipeds: presence of ST73, ST95, ST141 and ST131.
The study identified the presence of human-associated Escherichia coli clonal groups, including ST131, in Antarctic pinnipeds. It also characterized resistance genes such as blaTEM-1 and tet(A) in some isolates.
Antimicrobial Resistance in Streptococcus spp.
The paper discusses the prevalence and mechanisms of antimicrobial resistance in Streptococcus species, particularly focusing on macrolide, lincosamide, and tetracycline resistance. Key genes identified include erm(B), erm(A), lnuB, lnuD, mefA, mefE, msr, tet(B), tet(K), tet(L), tet(M), tet(O), and tet(S).
Genomic Analysis of a Pan-Resistant Isolate of Klebsiella pneumoniae, United States 2016.
The study reports a pan-resistant Klebsiella pneumoniae isolate with resistance to all 26 antibiotics tested, including multiple beta-lactamases, aminoglycoside modifying enzymes, sulfonamide resistance, and colistin resistance due to mgrB inactivation.
Various Profiles of tet Genes Addition to tet(X) in Riemerella anatipestifer Isolates From Ducks in China.
The study identified and characterized multiple tetracycline resistance genes, including tet(A), tet(B), tet(M), tet(O), tet(O/W/32/O), tet(Q), and tet(X), in Riemerella anatipestifer isolates from ducks in China. The tet(X) gene was found to be the primary mechanism of tetracycline resistance.
Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidal Salmonella enterica.
The study identified various AMR genes and mutations in non-typhoidal Salmonella enterica, including blaTEM-1, strA-strB, sul2, tet(A), qnrS1, aadA2, aadA17, floR, cmlA1, aac(3)-Id, aac(3)-IIa, dfrA12, dfrA1, dfrA14, blaCTX-M-9, blaCTX-M-55, blaSHV-12, blaPSE-1/blaCARB-2, and blaCMY-2, along with mutations in gyrA and parC associated with ciprofloxacin resistance.
Serotype Diversity and Antimicrobial Resistance among Salmonella enterica Isolates from Patients at an Equine Referral Hospital.
The study identified various AMR genes in Salmonella enterica isolates from equine patients, including beta-lactamases, aminoglycoside modifying enzymes, and genes conferring resistance to tetracyclines, macrolides, and other antibiotics.
An outbreak of a rare Shiga-toxin-producing Escherichia coli serotype (O117:H7) among men who have sex with men.
The study identified several AMR genes and mutations in STEC O117:H7 isolates, including the azithromycin resistance gene mphA, aadA1, aadA2, aadA5, blaTEM-1B, blaTEM-1C, dfrA1, dfrA12, dfrA14, dfrA, dfrA5, ermB, strA, strB, sul1, sul2, tet(A), tet(B), qnrs1, and a mutation in gyrA (S83L) associated with fluoroquinolone resistance.
Determination of Chlortetracycline Residues, Antimicrobial Activity and Presence of Resistance Genes in Droppings of Experimentally Treated Broiler Chickens.
The study identified the presence of tet(A) and tet(B) resistance genes in droppings of broiler chickens treated with chlortetracycline, indicating tetracycline resistance in E. coli isolates.
The Use of a Combined Bioinformatics Approach to Locate Antibiotic Resistance Genes on Plasmids From Whole Genome Sequences of Salmonella enterica Serovars From Humans in Ghana.
The study identified several AMR genes in Salmonella isolates from Ghana, including blaTEM-1B, blaTEM-52B, blaCTX-M-15, tet(A), dfrA15, sul1, sul2, catA1, strA, strB, aadA1, catB3, qnrB1, aac(6')Ib-cr, and blaOXA-1. These genes were found on various plasmids, highlighting the diversity of resistance mechanisms in the studied isolates.
Characterization of a novel multidrug resistance plasmid pSGB23 isolated from Salmonella enterica subspecies enterica serovar Saintpaul.
The study characterizes a novel multidrug resistance plasmid pSGB23 isolated from Salmonella enterica subspecies enterica serovar Saintpaul, carrying 11 antibiotic resistance genes responsible for resistance to 9 classes of antibiotics and quaternary ammonium compounds.
Current Status of the Use of Antibiotics and the Antimicrobial Resistance in the Chilean Salmon Farms.
The study identifies several AMR genes, including floR, tet(A), tet(B), tet(H), tet(l), tet(34), tet(35), aac(6')-Ib-cr, and intI1, associated with resistance to florfenicol, oxytetracycline, quinolones, and kanamycin in Chilean salmon farming environments.
Evolution of tigecycline- and colistin-resistant CRKP (carbapenem-resistant Klebsiella pneumoniae) in vivo and its persistence in the GI tract.
The study identifies the tet(A) gene variant in a conjugative plasmid as a mechanism for tigecycline resistance and the inactivation of the mgrB gene via IS 903B insertion as a mechanism for colistin resistance in CRKP strains.
Antimicrobial Resistance in Escherichia coli.
The paper discusses the characterization of various antimicrobial resistance genes in Escherichia coli, including extended-spectrum beta-lactamases (ESBLs), AmpC cephalosporinases, carbapenemases, plasmid-mediated quinolone resistance (PMQR) genes, aminoglycoside-modifying enzymes, fosfomycin resistance genes, and tetracycline resistance genes. These genes confer resistance to multiple classes of antibiotics, highlighting the complex nature of antimicrobial resistance in E. coli.
Genomic Characterization of MDR Escherichia coli Harboring bla(OXA-48) on the IncL/M-type Plasmid Isolated from Blood Stream Infection.
The study identified multiple AMR genes, including blaOXA-48, blaCTX-M-3, blaTEM-1B, blaOXA-1, aac(3)-IId, tet(A), tet(R), and blaCMY-70, in an MDR E. coli isolate. It also detected mutations in gyrA (S83L, D87N) and parC (S80I) contributing to fluoroquinolone resistance.
Tracing back multidrug-resistant bacteria in fresh herb production: from chive to source through the irrigation water chain.
The study identified multidrug-resistant bacteria in irrigation water and chive, highlighting the role of water quality in the transmission of antibiotic-resistant bacteria. Key resistance genes included blaCTX-M-15, mphA, and tet(A).
Identification of regions of the Streptococcus faecalis plasmid pCF-10 that encode antibiotic resistance and pheromone response functions.
The study identifies a tetracycline resistance determinant in the Streptococcus faecalis plasmid pCF-10 and maps regions involved in conjugal transfer and pheromone response.
Dynamics of antimicrobial resistance in intestinal Escherichia coli from children in community settings in South Asia and sub-Saharan Africa.
The study identified multiple AMR genes in aEPEC isolates from children in South Asia and sub-Saharan Africa, highlighting the prevalence of resistance to multiple antibiotics, including ampicillin, streptomycin, trimethoprim/sulphamethoxazole, and tetracycline.
A Comparison of Methods for the Extraction of Plasmids Capable of Conferring Antibiotic Resistance in a Human Pathogen From Complex Broiler Cecal Samples.
The study compared various plasmid extraction methods to identify those that effectively recover antibiotic resistance plasmids from complex broiler cecal samples. The exogenous plasmid isolation method was found to be the most consistent and reliable for obtaining a wide range of resistance plasmids.
Occurrence and Distribution of Tetracycline Antibiotics and Resistance Genes in Longshore Sediments of the Three Gorges Reservoir, China.
The study identified the presence of tetracycline resistance genes tet(A), tet(C), and tet(M) in longshore sediments of the Three Gorges Reservoir, with varying abundances across different zones and seasons.
Antimicrobial resistance genes in pathogenic Escherichia coli isolated from diseased broiler chickens in Egypt and their relationship with the phenotypic resistance characteristics.
The study identified multiple antimicrobial resistance genes in pathogenic E. coli isolates from broiler chickens in Egypt, including CITM, ere, aac(3)-(IV), tet(A), tet(B), dfr(A1), and aad(A1). These genes were associated with resistance to various antibiotics, highlighting the presence of multidrug-resistant E. coli in poultry.
Characterization of Salmonella enterica serovars recovered from meat products legally and illegally imported into the EU reveals the presence of multiresistant and AmpC-producing isolates.
The study identifies multiresistant Salmonella enterica isolates from legally and illegally imported meat, including AmpC-producing isolates carrying blaCMY-2, tet(A), and sul2 genes, which confer resistance to cephalosporins, tetracycline, and sulfonamides.
Interplay Between the Phenotype and Genotype, and Efflux Pumps in Drug-Resistant Strains of Riemerella anatipestifer.
The study identified multiple AMR genes and mutations in Riemerella anatipestifer, including aac(6')-Ib, aadA1, aadA2, aadA5, aac(3')-IIc, aac(3')-IV, aph(3')-VII, aph(2')-Ib, bla TEM, bla OXA, tet(A), tet(B), sul1, sul2, sul3, cat2, cmlA, floR, emrF, qnrS, and qnrD. Additionally, mutations in gyrA and parC were found to confer fluoroquinolone resistance.
Analysis of milk-derived isolates of E. coli indicating drug resistance in central Ethiopia.
The study identified tetracycline (tet(A)), chloramphenicol (cml(A)), and gentamicin (aac(3)-IV) resistance genes in E. coli isolates from milk in central Ethiopia, highlighting the presence of multidrug-resistant strains.
Genotypic and phenotypic characterization of Salmonella enterica subsp. enterica serovar Typhimurium monophasic variants isolated in Thailand and Japan.
The study identified several antimicrobial resistance genes in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variants, including blaTEM, aadA, strA, strB, tet(A), tet(B), tet(G), sul1, sul2, sul3, and floR, which confer resistance to ampicillin, streptomycin, oxytetracycline, sulfisoxazole, and chloramphenicol.
Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.
The study identified various AMR genes and mutations in carbapenem-resistant Klebsiella pneumoniae isolates, including bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-48, ampC, qnrB, qnrS, aac(6')-Ib-cr, armA, rmtB, tet(A), tet(B), tet(D), tet(G), sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, dfrA25, dfrA26, dfrA30, oqxA, oqxB, and mgrB, as well as mutations in ompK35, ompK36, gyrA, parC, phoP, phoQ, pmrA, and pmrB, which contribute to resistance against multiple antibiotics.
The Transferable Resistome of Produce.
The study identified multiple tetracycline resistance genes, beta-lactamases, and other resistance determinants in E. coli isolates from produce, highlighting the potential for horizontal gene transfer and the significance of the produce microbiome as a reservoir of antibiotic resistance genes.
The Transferable Resistome of Produce.
The study identified multiple tetracycline resistance genes, beta-lactamases, and other resistance determinants in E. coli isolates from produce, highlighting the potential for horizontal gene transfer and the significance of the produce microbiome as a reservoir of antibiotic resistance genes.
Interrelationship between tetracycline resistance determinants, phylogenetic group affiliation and carriage of class 1 integrons in commensal Escherichia coli isolates from cattle farms.
The study identified tetracycline resistance genes tet(A) and tet(B) as the most common in commensal E. coli isolates from cattle farms, along with gene cassettes such as aadA1, dfrA1, dfrA12, sul1, cat1, and floR associated with class 1 integrons.
Salmonella enterica Serovar Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial Resistance.
The study identified several AMR genes and mutations in S. Typhi isolates from Bangladesh, including blaTEM-1B, blaCTX-M-15, catA1, dfrA7, sul1, sul2, qnrS1, strA, strB, tet(A), tet(B), and mutations in gyrA and parE associated with ciprofloxacin resistance.
The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.
The study identifies multiple AMR genes associated with multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa, including genes encoding resistance to aminoglycosides, beta-lactams, chloramphenicol, trimethoprim, sulfonamides, and tetracyclines. It also notes mutations in the gyrA gene associated with reduced susceptibility to fluoroquinolones.
Complete Genome Sequence of bla (IMP-6)-Positive Metakosakonia sp. MRY16-398 Isolate From the Ascites of a Diverticulitis Patient.
The study identifies the blaIMP-6 gene, along with aacA4'-3, aadA2, and tet(A), as responsible for carbapenem and aminoglycoside resistance in the novel Metakosakonia sp. strain MRY16-398.
Draft Genome Sequence of a Tetracycline-Resistant Plesiomonas shigelloides Strain Isolated from Aquaculture-Reared Tilapia.
The draft genome sequence of Plesiomonas shigelloides strain FM82 reveals the presence of tetracycline resistance genes tet(A) and tet(D), as well as a fluoroquinolone resistance mutation S83I in gyrA.
Whole-genome sequences of multidrug-resistant Escherichia coli in South-Kivu Province, Democratic Republic of Congo: characterization of phylogenomic changes, virulence and resistance genes.
The study characterizes multidrug-resistant Escherichia coli isolates from South-Kivu Province, Democratic Republic of Congo, identifying several AMR genes including blaCTX-M-15, blaTEM-1, blaOXA-1, aac(6')-Ib, qnrS1, cat, sulI, sulII, tet(A), and dhfr. It also identifies chromosomal mutations in gyrA and parC contributing to quinolone resistance.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Cross-Border Transmission of Salmonella Choleraesuis var. Kunzendorf in European Pigs and Wild Boar: Infection, Genetics, and Evolution.
The study identified multiple antimicrobial resistance genes in Salmonella Choleraesuis isolates, including aadA1, catA1, cmlA1, floR, mph(B), strA, strB, sul1, sul2, sul3, tet(A), tet(B), dfrA1, aph(3')-Ia, lnu(B), and blaTEM-1. These genes conferred resistance to various antibiotics such as streptomycin, chloramphenicol, florfenicol, erythromycin, sulfamethoxazole, tetracycline, trimethoprim, gentamicin, lincomycin, and ampicillin.
ICESsuHN105, a Novel Multiple Antibiotic Resistant ICE in Streptococcus suis Serotype 5 Strain HN105.
The study identifies a novel integrative conjugative element (ICE), ICESsuHN105, carrying multiple antibiotic resistance genes in Streptococcus suis serotype 5 strain HN105, contributing to its multidrug resistance phenotype.
Manure and Doxycycline Affect the Bacterial Community and Its Resistome in Lettuce Rhizosphere and Bulk Soil.
The study identified the tetracycline resistance gene tetA(P) as being highly enriched in manure-treated soil and rhizosphere, particularly in doxycycline-treated bulk soil, indicating its potential as a marker for soil contamination by antibiotic-resistant bacteria and antibiotics.
Whole-Genome Sequencing Analysis of Nontyphoidal Salmonella enterica of Chicken Meat and Human Origin Under Surveillance in Sri Lanka.
The study identified several AMR genes in nontyphoidal Salmonella enterica isolates from chicken meat and human sources in Sri Lanka, including blaCTX-M-15, fosA7, aph(6)-Id, tet(A), blaTEM-1B, qnrS1, sul3, and dfrA14.
Deletions in the tetracycline resistance determinant reduce the thermosensitivity of a trfA(Ts) derivative of plasmid RP1 in Pseudomonas aeruginosa.
The study identifies that deletions in the tetracycline resistance determinant of plasmid RP1 reduce the thermosensitivity of a trfA(Ts) derivative in Pseudomonas aeruginosa, indicating that the tet gene products destabilize the plasmid replicon at higher temperatures.
Multiomics Assessment of Gene Expression in a Clinical Strain of CTX-M-15-Producing ST131 Escherichia coli.
The study identifies multiple AMR genes and mutations in the CTX-M-15-producing ST131 E. coli strain C999, including beta-lactamases (blaCTX-M-15, blaTEM-1, blaOXA-1), aminoglycoside resistance gene (aac(6')-Ib-cr), tetracycline resistance gene (tet(A)), sulfonamide resistance gene (sul1), and aadA5 gene cassette. Mutations in gyrA and parC contribute to fluoroquinolone resistance.
Antibiotic Resistance of E. coli Isolated From a Constructed Wetland Dominated by a Crow Roost, With Emphasis on ESBL and AmpC Containing E. coli.
The study identified bla ctx-M and bla cmy-2 genes as major contributors to extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase resistance in E. coli isolates from a constructed wetland dominated by a crow roost. Tetracycline resistance was primarily mediated by tet (A), tet (B), and tet (M), while streptomycin resistance was linked to strA, strB, and aadA. Sulfamethoxazole/trimethoprim resistance was associated with the sul1 gene.
Genomic Features of High-Priority Salmonella enterica Serovars Circulating in the Food Production Chain, Brazil, 2000-2016.
The study identified several AMR genes in Salmonella enterica isolates from Brazil, including qnrE1, qnrB19, qnrS1, blaCTX-M-2, blaCTX-M-8, blaCMY-2, aadA1, aadA2, aac(3)-IVa, aac(3)-IIa, aac(6')-Ib, floR, sul1, sul2, tet(A), tet(B), strA, strB, drfA1, inu(F), qacEdelta1, and fosA7. These genes conferred resistance to various antibiotics such as fluoroquinolones, beta-lactams, aminoglycosides, sulfonamides, tetracyclines, chloramphenicol, trimethoprim, macrolides, quaternary ammonium compounds, and fosfomycin.
Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal.
Emergence of Multidrug-Resistant Salmonella enterica Serovar Goldcoast Strains in Taiwan and International Spread of the ST358 Clone.
The study identifies multiple multidrug-resistant Salmonella enterica serovar Goldcoast strains in Taiwan, highlighting the emergence of an ST358 clone carrying various resistance genes, including blaCTX-M-55, mcr-1, and others, contributing to the rapid increase in infections.
Prevalence, Genotypic Characteristics and Antibiotic Resistance of Listeria monocytogenes From Retail Foods in Bulk in Zhejiang Province, China.
The study identified tetracycline resistance in Listeria monocytogenes isolates from retail foods in Zhejiang Province, China.
Tracking Carbapenem-Producing Klebsiella pneumoniae Outbreak in an Intensive Care Unit by Whole Genome Sequencing.
The study identified multiple carbapenem-resistant Klebsiella pneumoniae (CP-Kp) strains carrying various resistance genes, including blaKPC-2, blaNDM-1, and others, contributing to multidrug resistance. Plasmid analysis revealed the presence of resistance genes on different plasmids, highlighting the complexity of resistance mechanisms.
Detection of multi-drug resistant (MDR) Escherichia coli and tet gene prevalence at a pig farm in Kupang , Indonesia.
The study detected high levels of multidrug-resistant (MDR) Escherichia coli in pig farms in Kupang, Indonesia, with a significant prevalence of tet(A) and tet(E) genes associated with tetracycline resistance.
Impact of cleaning and disinfection procedures on microbial ecology and Salmonella antimicrobial resistance in a pig slaughterhouse.
The study identified resistance to ampicillin, sulfamethoxazole, and tetracycline in Salmonella isolates from a pig slaughterhouse, with no significant changes in resistance patterns after cleaning and disinfection procedures.
Antimicrobial Resistance Mechanisms in Antibiotic-Producing Bacteria and Pathogens
The paper discusses various antimicrobial resistance mechanisms in antibiotic-producing bacteria and pathogens, focusing on genes and mutations that confer resistance to different classes of antibiotics, including beta-lactams, aminoglycosides, tetracyclines, chloramphenicol, macrolides, and others.
Shedding of OXA-181 carbapenemase-producing Escherichia coli from companion animals after hospitalisation in Switzerland: an outbreak in 2018.
The study identified the carbapenemase gene blaOXA-181, the quinolone resistance gene qnrS1, the cephalosporinase gene blaCMY-42, and the tetracycline resistance gene tet(A) in carbapenemase-producing Escherichia coli isolates from companion animals in Switzerland. Additionally, chromosomal mutations in GyrA and ParC were associated with high-level fluoroquinolone resistance.
Inter-host Transmission of Carbapenemase-Producing Escherichia coli among Humans and Backyard Animals.
The study identified blaNDM genes as the primary cause of carbapenem resistance in Escherichia coli isolates from humans, pigs, chickens, and flies in rural China, highlighting the transmission of these resistance genes between humans and backyard animals.
The Resistome, Mobilome, Virulome and Phylogenomics of Multidrug-Resistant Escherichia coli Clinical Isolates from Pretoria, South Africa.
The study characterized the resistome, mobilome, and virulome of 20 multidrug-resistant E. coli isolates from Pretoria, South Africa. Key findings include the identification of various beta-lactamase genes (blaCTX-M-15, blaCTX-M-14, blaCTX-M-27, blaOXA-1, blaOXA-10, blaTEM-1B), aminoglycoside resistance genes (aac(3)-IIa, aac(3)-IId, aac(6')-Ib-cr, mph(A)), sulfonamide resistance genes (sul1, sul2, sul3), dihydrofolate reductase genes (dfrA17, dfrA14, dfrA1, dfrA5, dfrA7, dfrA12, dfrA23), tetracycline resistance genes (tet(A), tet(B)), chloramphenicol resistance genes (catB3, catA1), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE.
Antimicrobial usage in pig production: Effects on Escherichia coli virulence profiles and antimicrobial resistance.
The study identified tet(A) and tet(B) as tetracycline resistance genes in Escherichia coli isolates from pigs, with tet(A) being more prevalent in the antimicrobial group and tet(B) in the non-antimicrobial group.
Characteristics of a Colistin-Resistant Escherichia coli ST695 Harboring the Chromosomally-Encoded mcr-1 Gene.
The study identifies the chromosomally-encoded mcr-1 gene in a colistin-resistant E. coli ST695 strain, along with various other resistance genes such as bla NDM-1, aadA1, aadA2, aph(3')-Ia, aph(3')-VI, rmtB, cmlA1, floR, tet(A), tet(M), dfrA12, oqxA, oqxB, qnrS1, mph(A), bla TEM-105, and bla TEM-1B, contributing to its multidrug-resistant phenotype.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Emergence of carbapenemase-producing Enterobacteriaceae in Malawi.
The study reports the detection of an NDM-5 producing E. coli in Malawi, highlighting the emergence of carbapenem-resistant Enterobacteriaceae in the region.
New Delhi Metallo-β-Lactamase-5-Producing Escherichia coli in Companion Animals, United States.
The study identifies a carbapenem-resistant Escherichia coli isolate producing New Delhi metallo-beta-lactamase-5 (blaNDM-5) in companion animals in the United States, along with several other resistance genes including tet(A), aac(6')-Ib-cr, aadA5, aadA2, blaOXA-1, blaCTX-M-15, catB3, dfrA17, dfrA12, sul1, and mph(A).
Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing.
The study identified multiple AMR genes in extensively drug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (blaSHV-11, blaTEM-1B, blaVEB-1, blaOXA-10, blaKPC-2, blaOXA-9, blaVIM-27, blaCTX-M-15, blaOXA-1, blaOXA-48), aminoglycoside resistance genes (aadA1, ant(2'')-Ia, aph(6)-Id, arr-2, aadA24, aph(3')-Ia, aph(6)-Id, aac(3)-IIa, aac(6')Ib-cr, aac(6')-Ib, aac(6')-Ib-cr), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet(A), tet(G)), trimethoprim resistance genes (dfrA1, dfrA14, dfrA23), chloramphenicol resistance genes (cmlA1, catB4), and others.
Whole Genome Sequencing of Escherichia coli From Store-Bought Produce.
The study identified various antimicrobial resistance genes in tetracycline-resistant E. coli strains from store-bought produce, highlighting the prevalence of multidrug resistance and the role of plasmids and integrons in the spread of resistance.
Genomic Characterization of New Variant of Hydrogen Sulfide (H(2)S)-Producing Escherichia coli with Multidrug Resistance Properties Carrying the mcr-1 Gene in China †
The study reports the first detection of a hydrogen sulfide (H2S)-producing Escherichia coli variant isolated from a human in China, with multidrug resistance properties, including colistin resistance mediated by the mcr-1 gene, along with other resistance genes such as aadA1, aadA2, dfrA12, blaTEM-1B, oqxA, oqxB, floR, cmlA1, sul3, and tet(A).
Comparative genomic analysis reveals high intra-serovar plasticity within Salmonella Napoli isolated in 2005-2017.
The study identifies acquired antimicrobial resistance genes in Salmonella Napoli, including aadA, bla, tet, and sul, which confer resistance to streptomycin, beta-lactams, tetracyclines, and sulfonamides, respectively.
Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: prevalence, risk factors, and molecular epidemiology.
The study identified several AMR genes in Gram-negative bacteria isolated from LTCF residents, including bla CTX-M-27, bla CTX-M-14, bla TEM-1B, bla IMP-1, and others, which confer resistance to various antibiotics such as β-lactams, aminoglycosides, and fluoroquinolones.
Putative Protein Biomarkers of Escherichia coli Antibiotic Multiresistance Identified by MALDI Mass Spectrometry.
The study identifies several AMR genes in E. coli isolates, including tet(A), tet(B), blaCTX-M, blaTEM, blaSHV, sul1, sul2, sul3, cmlA, aac(3)-II, aac(3)-IV, aadA, and strA-strB, which confer resistance to tetracycline, ampicillin, cefoxitin, trimethoprim-sulfamethoxazole, chloramphenicol, gentamicin, and streptomycin.
Metadata Analysis of mcr-1-Bearing Plasmids Inspired by the Sequencing Evidence for Horizontal Transfer of Antibiotic Resistance Genes Between Polluted River and Wild Birds.
The study identifies the mcr-1 gene as a key factor in colistin resistance in E. coli strains isolated from polluted rivers and wild birds. It also characterizes several other AMR genes including aadA1, aadA2, aph(3′)-Ia, aph(3″)-Ib, aph(4)-Ia, aph(6)-Id, tet(B), tet(D), tet(A), bla CTX–M–14, bla TEM–1, qnrS2, oqxA, oqxB, cmlA1, floR, vgaC, sul1, sul2, sul3, dfrA12, and glpT (E448K).
Antibiotic-resistant Escherichia coli isolated from urban rodents in Hanoi, Vietnam.
The study identified multiple antimicrobial resistance genes in Escherichia coli isolated from urban rodents in Hanoi, Vietnam, including bla TEM, tet(A), sul1, sul2, sul3, and mcr-1, highlighting the potential of rodents as reservoirs of multidrug-resistant and colistin-resistant E. coli.
Genomic Analysis of GC1 Strains from H1 Hospital
The study identifies various AMR genes in GC1 Group 1 and Outgroup Group 3 genomes, including aac(6')-Ib, aph(3')-Ia, aac(3)-IIa, sul1, sul2, tet(A), tet(G), catA1, intI1, intI2, and efflux pumps adeABC, adeIJK, and adeFGH. These genes contribute to multidrug resistance in Acinetobacter baumannii.
Novel Insights and Features of the NDM-5-Producing Escherichia coli Sequence Type 167 High-Risk Clone.
The study identifies the NDM-5-producing Escherichia coli sequence type 167 clone, highlighting its resistance mechanisms and the presence of various resistance genes such as blaNDM-5, aadA2, dfrA12, sul1, tet(A), mphA, rmtB, and aac(3)-IIa.
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
The study identified several AMR genes and mutations in Salmonella Typhi isolates, including beta-lactamases (blaTEM-1B, blaTEM-116), chloramphenicol resistance gene (catA1), trimethoprim resistance genes (dfrA7, dfrA15), sulfamethoxazole resistance genes (sul1, sul2), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE genes.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines.
The study identifies various carbapenemase genes such as blaNDM-1, blaNDM-7, blaCTX-M-15, and blaOXA-181, along with other AMR genes like rmtC, sul1, aac(6')-Ib-cr, mph(A), qnrB1, and others, which contribute to resistance against multiple antibiotics in Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa in the Philippines.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Characterizing Antimicrobial Resistant Escherichia coli and Associated Risk Factors in a Cross-Sectional Study of Pig Farms in Great Britain.
The study identified tetracycline resistance gene tet(A), beta-lactamase bla TEM-1b, streptomycin resistance genes strAB, and plasmid-mediated quinolone resistance gene qnrS1 in E. coli isolates from pig farms in Great Britain. Chromosomal mutations in gyrA and parC were also linked to fluoroquinolone resistance.
Plasmid Replicon Typing of Antibiotic-Resistant Escherichia coli From Clams and Marine Sediments.
The study identified various antibiotic resistance genes in E. coli isolates from clams and marine sediments, including blaTEM, blaSHV, blaCTX-M, tet(A), dfrA1, aadA, strA, strB, and ant(3"). These genes were associated with resistance to beta-lactams, tetracycline, trimethoprim/sulfamethoxazole, and streptomycin.
Genomic characterization of multidrug-resistant ESBL-producing Escherichia coli ST58 causing fatal colibacillosis in critically endangered Brazilian merganser (Mergus octosetaceus).
The study identifies a multidrug-resistant ESBL-producing E. coli ST58 strain (PMPU) isolated from a critically endangered Brazilian merganser, carrying genes conferring resistance to various antibiotics, heavy metals, and disinfectants, along with fluoroquinolone resistance mutations.
Genomic analyses of multidrug-resistant Salmonella Indiana, Typhimurium, and Enteritidis isolates using MinION and MiSeq sequencing technologies.
The study identified various AMR genes in multidrug-resistant Salmonella isolates, including beta-lactamases (blaCTX-M-14, blaCTX-M-27, blaCTX-M-55, blaOXA-1, blaCMY-2, blaOXA, blaCMY), phenicol resistance genes (catB3, cmlA1, floR, catA1, catA2, oqxA, oqxB), aminoglycoside resistance genes (aac(6')-Ib-cr5, aac(6')-Ib-cr, oqxA2, qepA1, qnrS1), sulfonamide and trimethoprim resistance genes (sul1, sul2, sul3, dfrA12, dfrA7), and tetracycline resistance genes (tet(A), tet(B), tet(M)).
Whole Genome Sequencing and Characterization of Multidrug-Resistant (MDR) Bacterial Strains Isolated From a Norwegian University Campus Pond.
The study identifies multiple AMR genes and mutations in ESBL-producing bacteria from Norwegian freshwater environments, highlighting the presence of multidrug-resistant strains with resistance to various antibiotics including beta-lactams, fluoroquinolones, and sulfonamides.
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The study identified multiple AMR genes, including bla CTX-M-55, bla CMY-2, bla CTX-M-1, bla SHV-12, sul2, aac(3)-Ia, aadA, strA, strB, tet(A), tet(B), dfrA14, floR, cmlA1, catA1, catB3, qnrS1, qnrS2, qnrB19, mph(A), mph(B), arr-3, and aac(6')Ib-cr, in ESBL/pAmpC-producing E. coli isolates from broiler production.
Whole-Genome-Based Survey for Polyphyletic Serovars of Salmonella enterica subsp. enterica Provides New Insights into Public Health Surveillance.
The study identifies antimicrobial resistance (AMR) profiles in specific lineages of Salmonella enterica subsp. enterica serovars, highlighting the presence of resistance genes such as aac(6')-Ib, aph(3')-Ib, sul2, and tet(A) in host-preferred lineages, indicating that AMR profiles are lineage-specific and associated with niche preference.
Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment.
This review discusses the mechanisms that protect Acinetobacter baumannii against multiple stresses, including those from the host immune response, antibiotics, and the outside environment. It highlights the role of surface glycoconjugates, outer membrane components, and various virulence factors in evading immune defenses and surviving adverse conditions.
Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment.
This review discusses the mechanisms that protect Acinetobacter baumannii against multiple stresses, including those from the host immune response, antibiotics, and the outside environment. It highlights the role of surface glycoconjugates, outer membrane components, and various virulence factors in evading immune defenses and surviving adverse conditions.
Occurrence and Antimicrobial Resistance Traits of Escherichia coli from Wild Birds and Rodents in Singapore.
Emergence of Multidrug-Resistant Salmonella enterica Subspecies enterica Serovar Infantis of Multilocus Sequence Type 2283 in German Broiler Farms.
Merging Metagenomics and Spatial Epidemiology To Understand the Distribution of Antimicrobial Resistance Genes from Enterobacteriaceae in Wild Owls.
The study identified several antimicrobial resistance genes, including bla TEM, tet (A), and oqxAB, in Enterobacteriaceae from wild owls, highlighting the presence of resistance genes in natural ecosystems.
Development of an NGS-Based Workflow for Improved Monitoring of Circulating Plasmids in Support of Risk Assessment of Antimicrobial Resistance Gene Dissemination.
The study developed an optimized NGS-based workflow for plasmid reconstruction, enabling the identification of AMR genes such as mcr-1.1, blaTEM-1B, and others, which are critical for understanding the dissemination of antimicrobial resistance.
Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study.
The study identified 55 different antimicrobial resistance determinants in diarrheal pathogens, highlighting the presence of genes conferring resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, macrolides, tetracyclines, phenicols, sulfonamides, and others. Notably, carbapenemase genes like bla OXA-48 and bla NDM were detected in certain isolates, indicating emerging resistance concerns.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Comparative Genomic Analysis of 450 Strains of Salmonella enterica Isolated from Diseased Animals.
The study identified 60 antimicrobial resistance genes (ARGs), 4 disinfectant resistance genes (DRGs), and 33 heavy metal resistance genes (HMRGs) in 450 Salmonella strains isolated from diseased animals. These genes contributed to resistance against multiple antimicrobial classes, including aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and phenicols.
Molecular Characteristics and Zoonotic Potential of Salmonella Weltevreden From Cultured Shrimp and Tilapia in Vietnam and China.
The study identified aminoglycoside resistance gene aac(6')-Iaa, streptomycin resistance genes strA and strB, sulfonamide resistance gene sul2, tetracycline resistance gene tet(A), and a quinolone resistance mutation in parC (p.T57S) in Salmonella Weltevreden isolates from shrimp and tilapia in Vietnam and China.
Prevalence and multilocus sequence typing of Clostridium perfringens isolated from 4 duck farms in Shandong province, China.
The study identified the presence of cpb2 and cpe toxin genes in Clostridium perfringens isolates from duck farms in Shandong, China, with cpb2 prevalence at 30.85% and cpe at 0.5%. High levels of antibiotic resistance were observed, particularly to gentamicin, bacitracin, lincomycin, and tetracycline.
Genome Characterization of mcr-1-Positive Escherichia coli Isolated From Pigs With Postweaning Diarrhea in China.
The study identifies multiple antimicrobial resistance genes, including mcr-1.1 and mcr-3.1, in multidrug-resistant E. coli isolates from pigs with postweaning diarrhea in China.
Characterization of Multidrug Resistance Patterns of Emerging Salmonella enterica Serovar Rissen along the Food Chain in China.
The study identified multiple AMR genes in Salmonella enterica serovar Rissen isolates, including tet(A), blaTEM-1B, aadA2, aadA1, aac(6')-Iaa, aph(3")-lld, sul3, and dfrA12, which confer resistance to various antibiotics such as tetracycline, ampicillin, streptomycin, sulfisoxazole, and trimethoprim-sulfamethoxazole.
American Crows as Carriers of Extra Intestinal Pathogenic E. coli and Avian Pathogenic-Like E. coli and Their Potential Impact on a Constructed Wetland.
The study identifies several AMR genes, including blaCMY-2, blaCTX-M, tet(A), tet(B), strA, and strB, in E. coli isolates from crows and wetland water, highlighting the potential for these genes to be transferred via plasmids and contributing to the spread of antibiotic resistance.
Can domestic pigeon be a potential carrier of zoonotic Salmonella?
The study identified several antimicrobial resistance genes in Salmonella enterica serovar Typhimurium isolated from domestic pigeons, including strB, tet(A), floR, sul1, and blaTEM-1, which confer resistance to aminoglycosides, tetracyclines, florfenicol, sulfonamides, and beta-lactams, respectively.
Comprehensive screening of genomic and metagenomic data reveals a large diversity of tetracycline resistance genes.
The study identified 17 novel tetracycline resistance genes, including enzymatic degradation, ribosomal protection, and efflux pump genes, which conferred resistance in E. coli. These genes were found in various environments and showed potential for horizontal gene transfer.
Genomic Characterization of Salmonella Minnesota Clonal Lineages Associated with Poultry Production in Brazil.
The study identified multiple antimicrobial resistance genes, including aac(6')-Iaa, mdf(A), sul2, tet(A), blaCMY-2, aph(3')-Ia_1, qnrB19, and ant(3'')-Ia, in Salmonella Minnesota isolates from Brazilian poultry farms, indicating widespread resistance to various antibiotics.
Complete Genomic Analysis of VRE From a Cattle Feedlot: Focus on 2 Antibiotic Resistance.
The study identified multiple antibiotic resistance genes in vancomycin-resistant enterococci (VRE) isolates from a cattle feedlot, including vanC1, vanC2/C3, vanXY-C, VanR, macA, macB, rlmA (II), erm(A), aac(6')-la, blaEC, tet(A), tet(L), S10p, gyrA, gyrB, msbA, S12p, rpoB, mdfA/cmr, liaF, liaR, liaS, bcrC, mprF, pgsA, ef-G, ef-TU, ddl, alr, kasA, isotRNA, inhA, fabl, murA, folA, and Dfr, which confer resistance to various antibiotics such as vancomycin, macrolides, aminoglycosides, β-lactams, tetracyclines, quinolones, and others.
Employing MIC Data for Mink Pathogens to Propose Tentative Epidemiological Cut-Off Values: A Step Toward Rationalizing Antimicrobial Use in Mink.
The study identified several AMR genes in mink pathogens, including beta-lactamases (blaTEM-1, blaCTX-M-1), tetracycline resistance genes (tet(A), tet(B)), aminoglycoside resistance genes (aadA5, aadA1), sulfonamide resistance genes (sul2), dihydrofolate reductase genes (dfrA1, dfrA5, dfrA8, dfrA14), macrolide/lincosamide/streptogramin B resistance genes (erm), lincomycin resistance gene (lnu(A)), spectinomycin resistance gene (spc), and additional sulfonamide and trimethoprim resistance genes (sul1, sul3, dfrK, dfrG).
The importance of using whole genome sequencing and extended spectrum beta-lactamase selective media when monitoring antimicrobial resistance.
The study highlights the utility of whole genome sequencing (WGS) in monitoring antimicrobial resistance (AMR) trends, particularly in identifying ESBL genes such as bla CTX-M-1, bla CTX-M-15, bla SHV-12, bla CMY-2, and bla DHA-1, along with other resistance genes like sul2, tet(A), dfrA17, aadA5, ant3-1a, strA, strB, and fosA3 in E. coli isolates from pig surveillance.
Salmonella identified in pigs in Kenya and Malawi reveals the potential for zoonotic transmission in emerging pork markets.
The study identified several AMR genes in Salmonella isolates from pigs in Kenya and Malawi, including dfrA14, sul2, aph(3''-1b), aph(6)-1d, blaTEM-1B, fosA7, tet(A), and tet(J). A single isolate with a gyrA(D87Y) mutation showed resistance to pefloxacin.
Whole-Genome Sequence Analysis of an Extensively Drug-Resistant Salmonella enterica Serovar Agona Isolate from an Australian Silver Gull (Chroicocephalus novaehollandiae) Reveals the Acquisition of Multidrug Resistance Plasmids.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Salmonella enterica serovar Agona isolate from a silver gull, including bla CTX-M-55, dfrA14, sul3, qnrS1, tet(A), bla TEM-1, and others, indicating the acquisition of multidrug resistance plasmids.
Does Shiga Toxin-Producing Escherichia coli and Listeria monocytogenes Contribute Significantly to the Burden of Antimicrobial Resistance in Uruguay?
The study identified several antimicrobial resistance genes in Shiga toxin-producing Escherichia coli (STEC) and Listeria monocytogenes isolates, including aph(3")-Ib, aph(3′)-Ia, aph(6)-Id, blaTEM-1B, sul2, tet(A), fosX, lin, norB, lde, mdrL, and fepA. These genes conferred resistance to various antibiotics such as ampicillin, trimethoprim-sulfamethoxazole, tetracycline, fosfomycin, lincomycin, ciprofloxacin, and erythromycin.
Whole Genome Sequencing of Ceftolozane-Tazobactam and Ceftazidime-Avibactam Resistant Pseudomonas aeruginosa Isolated from a Blood Stream Infection Reveals VEB and Chromosomal Metallo-Beta Lactamases as Genetic Determinants: A Case Report.
The study identifies multiple AMR genes in a multidrug-resistant Pseudomonas aeruginosa strain, including beta-lactamases (blaVEB-9, blaOXA-10, blaOXA-50, blaPDC-11), aminoglycoside resistance genes (aph(3')-IIb, aac(6')-Il, ant(2'')-Ia), fluoroquinolone resistance gene (crpP), phenicol resistance gene (catB7), and tetracycline resistance gene (tet(A)).
Multidrug-resistant Escherichia coli and Salmonella spp. isolated from pigeons.
The study identified multidrug-resistant Escherichia coli and Salmonella spp. from pigeons, highlighting resistance to several antibiotics including ampicillin, amoxicillin, gentamicin, tetracycline, erythromycin, and azithromycin.
Antimicrobial Resistance and Genomic Characterization of OXA-48- and CTX-M-15-Co-Producing Hypervirulent Klebsiella pneumoniae ST23 Recovered from Nosocomial Outbreak.
The study characterizes the AMR genes in a multidrug-resistant hypervirulent Klebsiella pneumoniae ST23 isolate, MAR14-456, which co-produces OXA-48 and CTX-M-15. The isolate shows resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.
Genomic epidemiology of Escherichia coli isolates from a tertiary referral center in Lilongwe, Malawi.
The study identifies the blaCTX-M-15 gene as a major contributor to cephalosporin resistance in Escherichia coli isolates from Malawi, along with other AMR genes such as aac(3)-IIa, aac(3)-IId, aadA5, ant(3'')-Ih, aph(3'')-Ib, aph(3')-Ia, aph(6)-Id, strA, strB, acrF, emrD, mdtM, blaTEM-1, catA1, catB3, dfrA17, sul2, mph(A), and tet(A).
Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid.
The study identifies the blaCTX-M-1 gene carried on an IncI1/ST3 plasmid in Enterobacter cloacae and Escherichia coli isolates from humans and wild animals in Guadeloupe, highlighting the dissemination of this resistance determinant in the environment.
Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica.
The study identified several β-lactamase genes, including bla CTX-M-5, bla OXA-1, bla CTX-M-15, bla CTX-M-3, and bla TEM-1, which contribute to extended-spectrum β-lactamase (ESBL) production in multidrug-resistant non-typhoidal Salmonella enterica isolates. Additionally, a mutation in the gyrA gene (D87N) was linked to quinolone resistance.
Genomic Characterization of VIM and MCR Co-Producers: The First Two Clinical Cases, in Italy.
The study characterizes two clinical Enterobacter cloacae complex isolates co-producing VIM and MCR enzymes, identifying specific AMR genes and their resistance mechanisms.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Collateral sensitivity associated with antibiotic resistance plasmids.
The study identifies several AMR genes carried by clinically relevant plasmids, including blaOXA-48, qnrS1, blaSHV-12, aac(6')-Ib3, blaVEB-9, qnrVC-1, sul1, tetA', tetC, dfrA1, dfrA23, blaVIM-1, aadA1, qacEΔ1, blaBEL-1, blaGES-5, blaIMP-8, and blaFOX-8. These genes confer resistance to various antibiotics, and the study highlights the collateral sensitivity associated with the acquisition of these plasmids.
Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids in Salmonella Serovars from Poultry in Nigeria.
The study identified various antimicrobial resistance genes in Salmonella isolates from Nigerian poultry, including aac(6')-Ia, aac(6')-Ib, aadA7, aph(3")-Ia, aph(3")-Ib, aph(6')-Id, aph(6')-Ic, aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-IIa, aac(3)-Id, sul1, sul2, sul3, tet(A), tet(M), qnrS1, qnrB19, blaTEM, dfrA14, dfrA15, dfrA17, catA1, cmlA1, and floR. Mutations in gyrA (Ser83Phe, Asp87Tyr) and parC (Thr57Ser, Ser80Ile) were also associated with resistance to nalidixic acid and ciprofloxacin.
Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates from Jurong Lake, Singapore with Whole-Genome-Sequencing.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-8, bla CTX-M-27, bla CTX-M-14, and bla CTX-M-55, along with mcr-1.1 and mcr-3.1 for colistin resistance. Additionally, various other resistance genes such as qnrS1, mdf(A), mph(A), and others were found in the isolates, indicating multidrug resistance.
Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya.
The study identified several AMR genes in Salmonella isolates from Kenya, including blaTEM-1, aadA1, strA, strB, catA1, dhfr1, sul1, and sul2, which confer resistance to various antibiotics such as penicillins, cephalosporins, streptomycin, chloramphenicol, trimethoprim, and sulfonamides.
Identification of Risk Factors Associated with Resistant Escherichia coli Isolates from Poultry Farms in the East Coast of Peninsular Malaysia: A Cross Sectional Study.
The study identified several AMR genes in E. coli isolates from poultry farms in Malaysia, including aac(3)-IV, tet(A), tet(B), and sul1, which confer resistance to gentamicin, tetracyclines, and sulfonamides.
Genome-wide genetic marker analysis and genotyping of Escherichia fergusonii strain OTSVEF-60.
The study identified multiple antimicrobial resistance genes in Escherichia fergusonii strain OTSVEF-60, including aadA2, blaTEM-1, dfrA12, qnrS1, sul1, sul2, and tet(A), which confer resistance to aminoglycosides, beta-lactams, diaminopyrimidines, fluoroquinolones, sulfonamides, and tetracyclines.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Characterization of multidrug-resistant Acinetobacter baumannii strain ATCC BAA1605 using whole-genome sequencing.
The study identified multiple antimicrobial resistance (AMR) genes in the multidrug-resistant Acinetobacter baumannii strain ATCC BAA1605, including blaOXA-23, tet(A), and aadA1, which confer resistance to carbapenems, tetracycline, and aminoglycosides, respectively.
Wild Boars Carry Extended-Spectrum β-Lactamase- and AmpC-Producing Escherichia coli.
Wild boars in Germany carry ESBL/AmpC-producing E. coli, with bla CTX-M-1, bla SHV-12, and bla CMY-2 being the most common beta-lactamase genes. Additional resistance genes include sul1, sul2, sul3, dfrA1, dfrA5, dfrA14, dfrA17, tet(A), cmlA, floR, and qnrS.
The Plasmid-Borne tet(A) Gene Is an Important Factor Causing Tigecycline Resistance in ST11 Carbapenem-Resistant Klebsiella pneumoniae Under Selective Pressure.
The study identifies the plasmid-borne tet(A) gene as a significant factor in tigecycline resistance in ST11 carbapenem-resistant Klebsiella pneumoniae. Mutations in the tet(A) gene were found to contribute to high-level tigecycline resistance.
Deceiving Phenotypic Susceptibility Results on a Klebsiella pneumoniae Blood Isolate Carrying Plasmid-Mediated AmpC Gene bla(DHA-1).
The study identifies a carbapenem-resistant Klebsiella pneumoniae isolate carrying the plasmid-mediated AmpC gene blaDHA-1, along with other resistance genes such as blaOXA-1, aac(6')-Ib-cr, aph(3')-Ia, sul1, oqxA, oqxB, qnrB4, arr-3, tet(A), catB3, mph(A), fosA, IncFIB(K), and IncR.
Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance in Escherichia coli from German Broiler Fattening Farms.
The study identified various AMR genes in E. coli isolates from German broiler farms, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-1C, blaCTX-M-1, blaCMY-2), quinolone resistance genes (qnrB19, qnrS1), chloramphenicol resistance gene (cat1), tetracycline resistance genes (tetA, tetB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase genes (drfA1, drfA5, drfA14, drfA17), aminoglycoside resistance gene (aadA1), and efflux pump genes (sugEp, qacEΔ1, mdfA).
Molecular Detection of Antibiotic Resistance Genes in Shiga Toxin-Producing E. coli Isolated from Different Sources.
The study identified multiple antibiotic resistance genes in Shiga toxin-producing E. coli (STEC) isolates, including aadA1, aac(3)-I, ere(A), ampC, blaSHV, blaCMY, and tet(A), which conferred resistance to various antibiotics such as streptomycin, gentamicin, erythromycin, ampicillin, penicillin, cephalosporin, and tetracycline.
Antimicrobial Resistance Genes and Diversity of Clones among ESBL- and Acquired AmpC-Producing Escherichia coli Isolated from Fecal Samples of Healthy and Sick Cats in Portugal.
The study identified various ESBL and qAmpC genes in E. coli isolates from cats, highlighting the presence of bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-27, bla CTX-M-9, bla TEM, bla SHV-28, and bla CMY-2, along with other resistance genes such as tet(A), tet(B), sul1, sul2, aac(6')-Ib-cr, and armA.
Clonal Clusters, Molecular Resistance Mechanisms and Virulence Factors of Gram-Negative Bacteria Isolated from Chronic Wounds in Ghana.
The study identified various AMR genes and mutations in Gram-negative bacteria isolated from chronic wounds in Ghana, including beta-lactamases, fosfomycin resistance genes, chloramphenicol resistance genes, aminoglycoside resistance genes, fluoroquinolone resistance genes, tetracycline resistance genes, sulfonamide resistance genes, trimethoprim resistance genes, and efflux pumps. Mutations in gyrA, parE, and parC were also found to contribute to fluoroquinolone resistance.
Emergence of High Level Carbapenem and Extensively Drug Resistant Escherichia coli ST746 Producing NDM-5 in Influent of Wastewater Treatment Plant, Seoul, South Korea.
The study reports the emergence of a high-level carbapenem-resistant and extensively drug-resistant (XDR) Escherichia coli strain N7 producing NDM-5, highlighting the presence of multiple resistance genes on plasmids and chromosomes.
Comprehensive Pathogen Identification, Antibiotic Resistance, and Virulence Genes Prediction Directly From Simulated Blood Samples and Positive Blood Cultures by Nanopore Metagenomic Sequencing.
The study demonstrates the use of nanopore sequencing for rapid identification of pathogens, antibiotic resistance genes, and virulence genes from simulated blood samples and positive blood cultures. It identified 39 antibiotic resistance genes and 77 virulence genes in a Klebsiella pneumoniae strain, including blaKPC-2, blaSHV-12, blaTEM-1, blaCTX-M-65, rmtB, aadA, AAC(6')-IIb, baeR, mdtABC, acrAB, oqxAB, tet, H-NS, gyrA, and parC.
Genomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-Producing Escherichia coli Strains From Healthy Food Animals Across Europe.
The study identifies various ESBL and AmpC beta-lactamase genes, including bla SHV-12, bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla CTX-M-15, bla TEM-52, and bla CMY-2, along with the mcr-1 gene conferring colistin resistance in E. coli isolates from food animals in Europe.
Characterization of beta-lactam-resistant Escherichia coli from Australian fruit bats indicates anthropogenic origins.
The study identified various beta-lactam-resistant Escherichia coli strains from Australian fruit bats, highlighting the presence of multiple AMR genes such as bla TEM-1A, bla TEM-1B, bla CTX-M-27, bla NDM-5, and others, indicating anthropogenic origins of these resistant strains.
Antibiotic resistance among Escherichia coli and Salmonella isolated from dairy cattle feces in Texas.
The study identified bla CMY-2 and tet(A) as significant AMR genes in E. coli isolates from dairy cattle feces, alongside specific mutations in gyrA, pmrB, mef(B), and aph(3')-Ia.
Circulation of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli of Pandemic Sequence Types 131, 648, and 410 Among Hospitalized Patients, Caregivers, and the Community in Rwanda.
The study identifies the circulation of pandemic sequence types ST131, ST648, and ST410 of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in Rwanda, highlighting their multidrug resistance and potential for transmission among patients, caregivers, and the community.
Genomic Insights into Drug Resistance and Virulence Platforms, CRISPR-Cas Systems and Phylogeny of Commensal E. coli from Wildlife.
The study identified various AMR genes in commensal E. coli strains from wildlife, including bla TEM-1, bla CTX-M-1, tet(A), tet(B), and several resistance gene cassettes in integrons. These genes were found to confer resistance to multiple antibiotics, highlighting the presence of AMR in wildlife E. coli populations.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Genomic analysis and phylogenetic position of the complex IncC plasmid found in the Spanish monophasic clone of Salmonella enterica serovar Typhimurium.
The study identifies various AMR genes in the IncC plasmid pUO-STmRV1, including blaTEM-1, cmlA1, aac(3)-IV, aadA1, aadA2, sul1, sul2, sul3, tet(A), dfrA12, arsR2, arsH, merRTPCADE, and silESRCBAP, which confer resistance to antibiotics and heavy metals.
Clonal dissemination of Salmonella enterica serovar albany with concurrent resistance to ampicillin, chloramphenicol, streptomycin, sulfisoxazole, tetracycline, and nalidixic acid in broiler chicken in Korea.
The study identified multiple AMR genes in Salmonella enterica serovar Albany, including ampC, str, tet, sul, nal, and cat, which confer resistance to various antibiotics such as ampicillin, streptomycin, tetracycline, sulfisoxazole, nalidixic acid, and chloramphenicol. These findings highlight the multidrug-resistant nature of S. Albany isolates in Korean broiler chickens.
First Detection of Human ST131-CTX-M-15-O25-B2 Clone and High-Risk Clonal Lineages of ESBL/pAmpC-Producing E. coli Isolates from Diarrheic Poultry in Tunisia.
The study identified the presence of the human pandemic ST131-CTX-M-15-O25-B2 clone and high-risk clonal lineages of ESBL/pAmpC-producing E. coli isolates from diarrheic poultry in Tunisia, highlighting the emergence of multidrug-resistant clones with various virulence determinants.
Emerging Treatment Options for Multi-Drug-Resistant Bacterial Infections.
The paper discusses emerging antimicrobial options for multidrug-resistant (MDR) bacterial infections, focusing on new antibiotics and their mechanisms of action against various resistant pathogens.
The worldwide trend of Campylobacter spp., infection from duck-related isolates and associated phenotypic and genotypic antibiotic resistance, since 1985: identifying opportunities and challenges for prevention and control.
The study highlights the widespread presence of Campylobacter spp. in duck-related isolates and reports high resistance rates to fluoroquinolones, tetracycline, and other antibiotics. It emphasizes the need for improved surveillance and control measures to address antimicrobial resistance in Campylobacter.
Genomic evolution of antimicrobial resistance in Escherichia coli.
The study identified several AMR genes in Escherichia coli isolates from different animal sources in Europe, including blaTEM-1B, qnrB19, qnrS1, sul1, sul2, sul3, tet(A), aadA1, and aph(6)-Id. These genes were associated with resistance to beta-lactams, fluoroquinolones, sulfonamides, tetracyclines, and aminoglycosides.
Antibiotic Susceptibility Profile and Tetracycline Resistance Genes Detection in Salmonella spp. Strains Isolated from Animals and Food.
The study identified multiple tetracycline resistance genes (tet(A), tet(B), tet(C), tet(D), tet(E), and tet(G)) in Salmonella spp. strains isolated from animals and food, highlighting the prevalence of these genes and their potential role in the spread of antibiotic resistance.
Acquisition and loss of CTX-M plasmids in Shigella species associated with MSM transmission in the UK.
The study identifies the presence of bla CTX-M-27, erm(B), mph(A), aph(3')-Ib, aph(6)-Id, sul2, and tet(A) in Shigella isolates associated with MSM transmission in the UK, highlighting the role of plasmids in the spread of antimicrobial resistance.
Preliminary Results on the Prevalence of Salmonella spp. in Marine Animals Stranded in Sicilian Coasts: Antibiotic Susceptibility Profile and ARGs Detection in the Isolated Strains.
Three Salmonella spp. strains were isolated from marine animals in Sicily, showing resistance to ampicillin, tetracycline, and sulfamethoxazole. All strains harbored multiple antibiotic resistance genes, including blaTEM, blaOXA, tet(A), tet(D), tet(E), sulI, and sulII.
Genetic Features of Plasmid- and Chromosome-Mediated mcr-1 in Escherichia coli Isolates From Animal Organs With Lesions.
The study characterizes the mcr-1 gene and various other resistance genes in Escherichia coli isolates from animal organs with lesions, highlighting their multidrug resistance profiles and the genetic features of plasmids carrying these genes.
Whole Genome Sequencing of Pediatric Klebsiella pneumoniae Strains Reveals Important Insights Into Their Virulence-Associated Traits.
The study identified various AMR genes in K. pneumoniae strains, including beta-lactamases (blaSHV, blaOXA, blaTEM, blaCTX-M), fosfomycin resistance (fosA), quinolone resistance (oqxA, qnrB), chloramphenicol resistance (catB3), aminoglycoside resistance (aac(3), aadA1, strB), sulfonamide resistance (sul1), trimethoprim resistance (dfrA), and tetracycline resistance (tet(A)).
Multiple Mechanisms of Tigecycline Resistance in Enterobacteriaceae from a Pig Farm, China.
The study identifies tet(X) and tet(A) variants as key mechanisms of tigecycline resistance in Enterobacteriaceae from a pig farm in China, highlighting the role of plasmids and chromosomal elements in resistance dissemination.
Occurrence of Colibacillosis in Broilers and Its Relationship With Avian Pathogenic Escherichia coli (APEC) Population Structure and Molecular Characteristics.
The study identified multiple antimicrobial resistance genes in Avian Pathogenic Escherichia coli (APEC) isolates, including beta-lactamases (blaCMY-2, blaSHV-12, blaTEM-52, blaCTX-M-1), aminoglycoside resistance genes (aac(3)-IV, aadA, strA, strB, aph(3')-Ib), sulfonamide resistance gene (sul1), tetracycline resistance genes (tet(A), tet(B)), trimethoprim resistance gene (dfrA), quinolone resistance genes (qnrS1, qnrS2, qnrB19), macrolide resistance genes (mph(A), mph(B)), and chloramphenicol resistance gene (catA1).
Evaluation of the Stress Tolerance of Salmonella with Different Antibiotic Resistance Profiles.
The study identified florfenicol (FFC) and tetracycline (TET) resistance in Salmonella Typhimurium isolates, with some isolates showing multidrug resistance (MDR).
Characterization of ESBL-Producing Escherichia coli and Klebsiella pneumoniae Isolated from Clinical Samples in a Northern Portuguese Hospital: Predominance of CTX-M-15 and High Genetic Diversity.
The study identified the predominance of CTX-M-15 and high genetic diversity among ESBL-producing E. coli and K. pneumoniae isolates, including bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, bla KPC-2/3, bla SHV-12, bla SHV-27, bla SHV-11, bla SHV-28, tet(A), and tet(B) genes.
Changes in Antibiotic-Resistance Genes Induced by the Grazing Effect in Three Cladoceran Species.
The study found that the presence of Daphnia obtusa significantly reduced the abundance of tetracycline resistance gene (tet(A)) in water samples, indicating that cladocerans play a role in controlling antibiotic resistance genes in freshwater ecosystems.
Antimicrobial Resistance Patterns and Risk Factors Associated with Salmonella spp. Isolates from Poultry Farms in the East Coast of Peninsular Malaysia: A Cross-Sectional Study.
The study identified multiple antimicrobial resistance genes in Salmonella spp. isolates from poultry farms in Malaysia, including blaTEM, tet(A), tet(B), catA1, cat2, floR, sul1, and sul2, which confer resistance to beta-lactams, tetracyclines, chloramphenicol, and sulfonamides.
Diverse Bacterial Resistance Genes Detected in Fecal Samples From Clinically Healthy Women and Infants in Australia-A Descriptive Pilot Study.
The study identified 64 unique antimicrobial resistance genes (ARGs) in fecal samples from clinically healthy individuals in Australia, with a focus on tetracycline, beta-lactam, and MLS B resistance genes.
In vivo Emergence of Colistin and Tigecycline Resistance in Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae During Antibiotics Treatment.
The study reports the in vivo emergence of colistin and tigecycline resistance in carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) during antibiotic treatment. A novel G300E mutation in the type 1 Tet(A) variant was identified, which significantly increased tigecycline MIC. Additionally, insertional inactivation of the mgrB gene via IS1 and ISKpn14 contributed to colistin resistance.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance Profiles in Non-typhoidal Salmonella enterica Strains Isolated From Cambodian Informal Markets.
The study identified 17 unique AMR genes in 53% of the 81 S. enterica isolates, including genes encoding resistance to tetracycline, beta-lactam, sulfonamide, quinolone, aminoglycoside, phenicol, and trimethoprim.
IS1294 Reorganizes Plasmids in a Multidrug-Resistant Escherichia coli Strain.
The study identifies and characterizes various AMR genes, including blaCTX-M-55, rmtB, oqxAB, blaTEM-1b, floR, tet(A), strA, strB, sul1, sul2, aac(3)-IId, aadA2, dfrA12, and aph(3′)-IIa, in a multidrug-resistant E. coli strain. These genes contribute to resistance against multiple antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, tetracyclines, sulfonamides, and trimethoprim.
Analysis of antibiotic-induced drug resistance of Salmonella enteritidis and its biofilm formation mechanism.
The study identified several antibiotic resistance genes in Salmonella enteritidis, including sul2, sul3, blaTEM-1-like, tet(A), and tet(G). These genes contribute to resistance against sulfamethoxazole, ampicillin, cefoxitin, cefotaxime, cefoperazone, ceftriaxone, cefepime, and tetracycline.
Molecular Epidemiological Analysis of ST11-K64 Extensively Drug-Resistant Klebsiella pneumoniae Infections Outbreak in Intensive Care and Neurosurgery Units Based on Whole-Genome Sequencing.
The study identified multiple AMR genes in ST11-K64 XDRKp strains, including beta-lactamases, aminoglycoside resistance genes, and efflux pumps, contributing to extensive drug resistance.
Characterization of a pESI-like plasmid and analysis of multidrug-resistant Salmonella enterica Infantis isolates in England and Wales.
The study characterizes a pESI-like plasmid harboring multiple resistance genes, including bla CTX-M-65, in multidrug-resistant Salmonella enterica Infantis isolates from England and Wales. The plasmid was associated with resistance to beta-lactams, aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, sulfonamides, fosfomycin, and heavy metals.
Molecular Analysis and Antimicrobial Resistance Pattern of Tigecycline-Non-Susceptible K. pneumoniae Isolated from a Tertiary Care Hospital of East Asia.
The study identified tet(A) and rpsJ genes as contributing to tigecycline resistance in tigecycline-non-susceptible K. pneumoniae strains, along with mutations in ramR.
Genomic Analysis of Ciprofloxacin-Resistant Salmonella enterica Serovar Kentucky ST198 From Spanish Hospitals.
The study identified several AMR genes and mutations associated with ciprofloxacin resistance in Salmonella enterica serovar Kentucky ST198 isolates from Spanish hospitals. Key findings include the presence of blaTEM-1B, aacA5, aadA7, sul1, tet(A), catA1, and aac(6′)-Ib genes, along with mutations in gyrA (Ser83Phe) and parC (Thr57Ser, Ser80Ile).
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms.
The study identified several ESBL genes, colistin resistance genes, and other AMR genes in ESBL-producing E. coli from pigs and pig farm workers in Vietnam. Key findings include the prevalence of bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27, along with mcr-1 and mcr-3 for colistin resistance, and various other resistance genes for aminoglycosides, quinolones, tetracyclines, chloramphenicol, macrolides, and sulfonamides.
Identification of Three Novel PmGRI1 Genomic Resistance Islands and One Multidrug Resistant Hybrid Structure of Tn7-like Transposon and PmGRI1 in Proteus mirabilis.
The study identifies three novel variants of PmGRI1 and a hybrid structure combining Tn7-like transposon and PmGRI1 in Proteus mirabilis, highlighting their role in carrying multiple antibiotic resistance genes.
Investigation of the Genes Involved in the Outbreaks of Escherichia coli and Salmonella spp. in the United States.
The study identified several antimicrobial resistance genes in E. coli and Salmonella spp., including aadA1, aph(3"-Ib, aph(6)-Id, blaTEM-1, sul2, tet(A), and tet(B) in E. coli, and arsA, arsB, arsC, iroB, and iroC in Salmonella spp. Additionally, virulence genes such as epeA, stxA2d, stxB2c, subA, and subB were found to be unique to outbreak E. coli.
Can Human Handling Increase the Presence of Multidrug Resistance (MDR) in Salmonella spp. Isolated from Food Sources?
The study identified several AMR genes in MDR Salmonella strains, including bla TEM, bla CTXM, bla OXA, sul II, tet (A), and tet (B). These genes conferred resistance to various antibiotics such as ampicillin, cefotaxime, ceftazidime, sulfamethoxazole, trimethoprim, tetracycline, and tigecycline.
Transmission Dynamics of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 Strains Carrying Capsular Loci KL64 and rmpA/rmpA2 Genes.
The study identified multiple AMR genes and mutations in ST11-KL64 CRKP isolates, including bla KPC-2, rmtB, catA2, fosA, qnrS1, sul2, tet(A), aadA2, dfrA14, bla CTX-M-65, bla SHV-12, bla TEM-1B, iucABCD, iutA, rmpA2, and mutations in GyrA (S83I, D87G) and ParC (S80I).
Distribution and genomic characterization of tigecycline-resistant tet(X4)-positive Escherichia coli of swine farm origin.
The study identifies and characterizes the tigecycline resistance gene tet(X4) and a novel tet(A) variant, tet(A)-v, in Escherichia coli strains from swine farms, highlighting their role in multidrug resistance and the potential for horizontal gene transfer.
Distribution and genomic characterization of tigecycline-resistant tet(X4)-positive Escherichia coli of swine farm origin.
The study identifies and characterizes the tigecycline resistance gene tet(X4) and a novel tet(A) variant, tet(A)-v, in Escherichia coli strains from swine farms, highlighting their role in multidrug resistance and the potential for horizontal gene transfer.
Whole-Genomic Analysis of NDM-5-Producing Enterobacteriaceae Recovered from an Urban River in China.
The study identified multiple antimicrobial resistance genes, including bla NDM-5, bla OXA-10, and bla TEM-1B, in NDM-5-producing Enterobacteriaceae isolates from an urban river in China. These genes conferred resistance to various antibiotics such as carbapenems, cephalosporins, quinolones, and aminoglycosides.
Co-occurrence of Klebsiella variicola and Klebsiella pneumoniae Both Carrying bla (KPC) from a Respiratory Intensive Care Unit Patient.
The study identified Klebsiella variicola and Klebsiella pneumoniae strains carrying multiple resistance genes, including bla KPC-2, bla TEM-1A, bla LEN17, aadA16, arr-3, qnrB4, oqxA/B, dfrA27, sul1, tetD, fosA, qacEΔ1, bla CTX-M-3, bla TEM-1B, bla CTX-M-65, bla SHV-27, aac(6')-IIa, rmtB, aph(3')-Ia, aadA16, qnrS1, aac(6')-Ib-cr, qnrB91, oqxA/B, mph(A), tet(A), fosA, dfrA27, and two copies of qacEΔ1-sul1.
Bacteriological and histopathological findings in cetaceans that stranded in the Philippines from 2017 to 2018.
The study identified multiple antibiotic-resistant bacteria from cetaceans stranded in the Philippines, highlighting the presence of resistance genes such as ermB, aadA, aac(6')-Ib, blaTEM, blaCTX-M, blaSHV, blaOXA, qnrS1, tet(A), and mph(A).
Antimicrobial resistance in the globalized food chain: a One Health perspective applied to the poultry industry.
The paper discusses the prevalence of antimicrobial resistance in poultry-related pathogens such as Salmonella, Campylobacter, Enterococcus, E. coli, and S. aureus, highlighting resistance to various antibiotics including ampicillin, tetracycline, and ciprofloxacin.
Stepwise Evolution of a Klebsiella pneumoniae Clone within a Host Leading to Increased Multidrug Resistance.
The study identifies the acquisition of multiple AMR genes and mutations in a Klebsiella pneumoniae clone, leading to increased multidrug resistance. Key findings include the role of blaCTX-M-14, aac(3)-Iid, tet(A), qnrS1, sul1, dfrA1, acrAB-TolC, ompK35, and mgrB in conferring resistance to various antibiotics, along with mutations in ramR that contribute to resistance.
High Prevalence of Antibiotic-Resistant Escherichia coli Isolates from Retail Poultry Products in Spain.
The study identified blaTEM as the primary beta-lactam resistance gene and tet(A) as the dominant tetracycline resistance gene in E. coli isolates from retail poultry products in Spain.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Carbapenem-Resistant Citrobacter spp. as an Emerging Concern in the Hospital-Setting: Results From a Genome-Based Regional Surveillance Study.
The study identifies various carbapenemase genes, including bla KPC-2, bla OXA-48, bla VIM-1, bla NDM-5, bla OXA-162, and bla KPC-3, in Citrobacter spp. isolates, highlighting their role in carbapenem resistance.
Extensive Drug-Resistant Salmonella enterica Isolated From Poultry and Humans: Prevalence and Molecular Determinants Behind the Co-resistance to Ciprofloxacin and Tigecycline.
The study identified several AMR genes and mutations contributing to ciprofloxacin and tigecycline resistance in XDR Salmonella enterica isolates, including qepA, qnrS, qnrA, tet(A), and gyrA mutations. Overexpression of ramA was also linked to resistance.
Genomic diversity of antimicrobial resistance in non-typhoidal Salmonella in Victoria, Australia.
The study identified various AMR genes and mutations in non-typhoidal Salmonella, including bla TEM-1, bla TEM-135, strAB, sul1, sul2, tet(A), tet(B), floR, bla CMY-2, bla CTX-M-55, and bla CTX-M-65, along with mutations in gyrA and parC contributing to ciprofloxacin resistance.
Letter to the Editor: Importation of the First Bovine ST361 New Delhi Metallo-5 Positive Escherichia coli in Greece.
The study reports the first bovine ST361 NDM-5 positive Escherichia coli in Greece, highlighting the importation of multidrug-resistant strains and the need for continued surveillance.
Pan-Resistome Characterization of Uropathogenic Escherichia coli and Klebsiella pneumoniae Strains Circulating in Uganda and Kenya, Isolated from 2017-2018.
The study identified various AMR genes in uropathogenic E. coli and K. pneumoniae strains from Uganda and Kenya, highlighting the prevalence of multidrug-resistant (MDR) and extended-spectrum beta-lactamase (ESBL)-producing strains.
MALDI-TOF MS for rapid detection and differentiation between Tet(X)-producers and non-Tet(X)-producing tetracycline-resistant Gram-negative bacteria.
The study presents the MALDI Tet(X)-plus test, a rapid and reliable method for detecting Tet(X)-producers, non-Tet(X)-producing tetracycline-resistant, and tetracycline-susceptible Gram-negative bacteria. It identifies various tetracycline resistance genes such as tet(A), tet(B), tet(D), tet(G), tet(M), tet(X3), tet(X4), tet(X2)-tet(X6), tet(X3)-tet(X6), and TMexCD1-TOprJ1.
Genomic characteristics and comparative genomics of Salmonella enterica subsp. enterica serovar Schwarzengrund strain S16 isolated from chicken feces.
Outbreak of Multidrug-Resistant Salmonella Heidelberg Infections Linked to Dairy Calf Exposure, United States, 2015-2018.
The study identifies a multidrug-resistant (MDR) Salmonella Heidelberg outbreak linked to dairy calf exposure, highlighting the presence of plasmid-borne resistance genes such as aadA1, aph(3')-Ia, bla CMY-2, floR, fosA7, qnrB19, strA, strB, sull, sul2, tet(A), tet(B), tet(O), and a novel gene dfrA34.
Prevalence, Risk Factors, and Genetic Characterization of Extended-Spectrum Beta-Lactamase Escherichia coli Isolated From Healthy Pregnant Women in Madagascar.
The study identified blaCTX-M-15 as the most prevalent ESBL gene in ESBL-producing E. coli isolates from pregnant women in Madagascar, along with other CTX-M variants, blaNDM-5, blaCMY-2, and resistance genes such as qnrS1, sul2, dfrA14, aph(6)-Id, and aph(3')-Ib.
One Health Genomic Study of Human and Animal Klebsiella pneumoniae Isolated at Diagnostic Laboratories on a Small Caribbean Island.
The study identified various AMR genes in Klebsiella pneumoniae isolates from humans and animals on St. Kitts, including bla CTX-M-15, bla TEM-1b, bla TEM-206, bla OXA-1, and others, highlighting host-specific differences in resistance profiles.
The Darkest Place Is under the Candlestick-Healthy Urogenital Tract as a Source of Worldwide Disseminated Extraintestinal Pathogenic Escherichia coli Lineages.
The study identified several AMR genes and mutations in E. coli strains from the urogenital microbiome of healthy women, including blaTEM-30, tet(A), aac(3)-IId, sul1, dfrA12, and a gyrA mutation (S83L) conferring resistance to various antibiotics.
Comparative Whole-Genome Analysis of Russian Foodborne Multidrug-Resistant Salmonella Infantis Isolates.
The study identified multiple AMR genes in multidrug-resistant Salmonella Infantis isolates, including aac(6')-Iaa, ant(3")-Ia, tetABD, sul123, dfrA14, and blaCTX-M-14, which contribute to resistance against aminoglycosides, tetracycline, sulfonamides, trimethoprim, and cephalosporins.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
Escherichia fergusonii, an Underrated Repository for Antimicrobial Resistance in Food Animals.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia fergusonii isolates from food animals, including mcr-1, aph(6)-Id, aph(3')-Ib, and tet(A). These genes contribute to resistance against colistin, aminoglycosides, and tetracycline, highlighting E. fergusonii as a significant reservoir of AMR genes.
S. algae as a reservoir and a vehicle of potential antimicrobial resistance
The study identified multiple antimicrobial resistance genes in S. algae strains, including genes conferring resistance to beta-lactams, aminoglycosides, quinolones, phenicols, macrolides, sulfonamides, tetracyclines, and lincosamides.
Loads of Coliforms and Fecal Coliforms and Characterization of Thermotolerant Escherichia coli in Fresh Raw Milk Cheese.
The study identified antibiotic resistance genes blaSHV, blaCTX-M, qnrS, tet(A), and tet(B) in thermotolerant E. coli strains from raw milk cheese, highlighting the presence of multidrug-resistant strains and the need for monitoring antimicrobial resistance in food products.
Similarities in Virulence and Extended Spectrum Beta-Lactamase Gene Profiles among Cefotaxime-Resistant Escherichia coli Wastewater and Clinical Isolates.
The study identifies several beta-lactamase genes, including blaCTX-M-1, blaKPC-2, blaTEM-350, blaOXA-1, and blaCTX-M-15, as well as various aminoglycoside, macrolide, and tetracycline resistance genes in cefotaxime-resistant E. coli isolates from hospital and urban wastewater. Mutations in parC, parE, and gyrA contribute to fluoroquinolone resistance.
Mucilaginibacter sp. Strain Metal(loid) and Antibiotic Resistance Isolated from Estuarine Soil Contaminated Mine Tailing from the Fundão Dam.
The study identifies multiple AMR genes in Mucilaginibacter sp. 21p, including genes for resistance to quinolones, aminoglycosides, beta-lactamases, sulfonamides, tetracyclines, daptomycin, arsenic, zinc, manganese, cobalt, and cadmium. These genes are part of efflux pumps and other resistance mechanisms, indicating the strain's adaptability to metal(loid) and antibiotic stressors in contaminated environments.
Comparison of Reference-Based Assembly and De Novo Assembly for Bacterial Plasmid Reconstruction and AMR Gene Localization in Salmonella enterica Serovar Schwarzengrund Isolates.
The study identified various AMR genes in Salmonella enterica serovar Schwarzengrund isolates, including aadA2, AAC(3)-IV, AAC(6')-Iy, APH(4)-Ia, cmlA1, dfrA12, floR, sul1, sul2, sul3, TEM-1, and tet(A). These genes were located on both the chromosome and plasmids, highlighting the importance of plasmid-mediated AMR gene transmission.
Genomic Analysis of Escherichia coli Longitudinally Isolated from Broiler Breeder Flocks after the Application of an Autogenous Vaccine.
The study identified 25 antimicrobial resistance genes in E. coli isolates from broiler breeder flocks, with mdf(A) and sitABCD being the most prevalent. Tet(A) was also detected, primarily in Farm A.
Genetic Characterization of Antibiotic Resistant Enterobacteriaceae Isolates From Bovine Animals and the Environment in Nigeria.
The study characterizes antibiotic resistance genes in Enterobacteriaceae isolates from bovine animals and the environment in Nigeria, identifying several beta-lactamase, aminoglycoside modifying enzymes, qnr, sulfonamide, tetracycline, and trimethoprim resistance genes, highlighting the presence of multidrug-resistant strains.
A Metagenomic Approach for Characterizing Antibiotic Resistance Genes in Specific Bacterial Populations: Demonstration with Escherichia coli in Cattle Manure.
The study identified multiple antibiotic resistance genes in E. coli populations from cattle manure, including genes conferring resistance to tetracycline, aminoglycosides, chloramphenicol, sulfonamides, and glycopeptides. These genes were found to be associated with mobile genetic elements, highlighting the potential for horizontal gene transfer.
Virulome and genome analyses identify associations between antimicrobial resistance genes and virulence factors in highly drug-resistant Escherichia coli isolated from veal calves.
The study identifies multiple antimicrobial resistance genes (ARGs) in highly drug-resistant Escherichia coli isolates from veal calves, including blaCMY-2, blaCTX-M-15, mph(A), erm(B), aac(6')-Ib-cr, qnrS1, aadA5, aadA1, aph(3')-Ic, aph(3')-Ia, aph(3')-Ib, aph(6')-Id, sul1, sul2, tet(A), and tet(B). Additionally, mutations in gyrA (S83L, D87N) and parC (A56T) were found to contribute to fluoroquinolone resistance.
Genomic diversity and antimicrobial resistance among non-typhoidal Salmonella associated with human disease in The Gambia.
The study identified various antimicrobial resistance (AMR) genes in non-typhoidal Salmonella isolates from The Gambia, including aac(6')-Iaa_1, aph_3_Ib, aph_6_Id, dfrA14, dfrA7, dfrA8, blaTEM-1B, catA1_1, fosA7_1, mph_A, sul1, sul2, tet_A, and tet_B. These genes confer resistance to aminoglycosides, trimethoprim, beta-lactams, chloramphenicol, fosfomycin, macrolides, sulfonamides, and tetracyclines. The study also found that multidrug resistance (MDR) was primarily associated with Salmonella serovar Enteritidis, especially in the eastern region.
Global population structure of the Serratia marcescens complex and identification of hospital-adapted lineages in the complex.
The study identified multiple antimicrobial resistance (AMR) genes and mutations in the Serratia marcescens complex, highlighting the presence of hospital-adapted lineages with a high prevalence of multidrug-resistant (MDR) strains. Key AMR genes include blaCTX-M, blaNDM, blaOXA, qnrS1, tet(A), aac(6')-Ib, mph(A), erm(B), aadA, floR, sul1, and dfrA12, which confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, tetracyclines, aminoglycosides, macrolides, florfenicol, sulfonamides, and trimethoprim.
Metagenomic Approaches Reveal Strain Profiling and Genotyping of Klebsiella pneumoniae from Hospitalized Patients in China.
The study identified various antimicrobial resistance genes in Klebsiella pneumoniae strains, including blaKPC-2, blaKPC-3, blaSHV-11, CTX-M, qnrS1, and tet(A), which confer resistance to carbapenems, beta-lactams, fluoroquinolones, and tetracyclines.
Genomic Profiling of Antibiotic-Resistant Escherichia coli Isolates from Surface Water of Agricultural Drainage in North-Western Mexico: Detection of the International High-Risk Lineages ST410 and ST617.
The study identified multidrug-resistant Escherichia coli isolates from surface water in north-western Mexico, including international high-risk lineages ST410 and ST617. These isolates carried various AMR genes such as blaTEM-1B, blaCTX-M-15, aadA1, aadA2, aadA5, aac(3)-IIa, aac(3)-IId, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, floR, cmlA1, lnu(F), mdf(A), sul2, sul3, tet(A), tet(B), dfrA12, and dfrA17. Additionally, mutations in gyrA (S83L, D87N), parC (S80I), and parE (S458A) were found to contribute to fluoroquinolone resistance.
Prevalence and Diversity of Antibiotic Resistant Escherichia coli From Anthropogenic-Impacted Larut River.
The study identified several tetracycline and sulfonamide resistance genes, including tet(A), tet(L), tet(X), sul2, and sul3, in Escherichia coli isolates from the Larut River, highlighting the prevalence of antibiotic resistance in anthropogenically impacted aquatic environments.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2019-2020.
The report highlights the presence of various antimicrobial resistance genes such as blaVIM-1, blaTEM-1B, blaTEM-1C, and cfr in different bacterial isolates, indicating resistance to carbapenems, beta-lactams, and macrolides/lincosamides/streptogramin B.
Molecular Characteristics of Antimicrobial Resistance and Virulence in Klebsiella pneumoniae Strains Isolated from Goose Farms in Hainan, China.
The study identified bla NDM-5 as a prevalent carbapenem resistance gene in Klebsiella pneumoniae isolates from goose farms in Hainan, China. Additionally, other resistance genes such as bla CTX-M, aadA, oqxAB, tet, and mcr-1 were also detected, highlighting the complex resistance profiles of these isolates.
The Current Landscape of Antibiotic Resistance of Salmonella Infantis in Italy: The Expansion of Extended-Spectrum Beta-Lactamase Producers on a Local Scale.
The study identified multiple antimicrobial resistance genes in Salmonella Infantis strains from Italy, including blaCTX-M-1, aadA1, dfrA1, dfrA14, sul1, and tet(A), which contribute to resistance against various antibiotics such as beta-lactams, aminoglycosides, trimethoprim, sulfonamides, and tetracyclines.
Drinking water chlorination has minor effects on the intestinal flora and resistomes of Bangladeshi children.
The study identified several antibiotic resistance genes (ARGs) in the gut microbiome of Bangladeshi children, including bla CTX-M, mph(A), qnrS1, mdf(A), tet(A), sul2, aadA5, tet(X), erm(X), nimE, dfrA17, bla TEM, and ant(6’)-Ia. These genes were associated with resistance to various antibiotics such as third-generation cephalosporins, azithromycin, fluoroquinolones, tetracyclines, sulfonamides, streptomycin, spectinomycin, macrolides, lincosamides, streptogramin B, nitroimidazoles, trimethoprim, penicillins, and aminoglycosides.
In vitro Synergistic Activities of Fosfomycin in Combination with Other Antimicrobial Agents Against Carbapenem-Resistant Escherichia coli Harboring bla (NDM-1) on the IncN2 Plasmid and a Study of the Genomic Characteristics of These Pathogens.
The study identified several AMR genes in bla NDM-1 -harboring CREC isolates, including bla NDM-1, aac(3)-IId, aph(3")-Ib, aph(6)-Id, aadA5, aadA16, aac(6')-Ib-cr, qnrB6, ARR-3, dfrA17, dfrA27, sul1, sul2, tet(A), mph(A), bla TEM-1C, bla TEM-57, bla CTX-M-14, bla CTX-M-15, and bla CMY-2. These genes conferred resistance to various antibiotics, including carbapenems, aminoglycosides, fluoroquinolones, rifampicin, trimethoprim, sulfonamides, tetracycline, and macrolides.
Antimicrobial Resistance in Escherichia coli from the Broiler Farm Environment, with Detection of SHV-12-Producing Isolates.
The study identifies SHV-12-producing Escherichia coli isolates in a broiler farm environment, highlighting the presence of various antimicrobial resistance genes such as bla SHV-12, cmlA, tet (A), aac(6′)-Ib-cr, and others. These genes confer resistance to multiple antibiotics, emphasizing the need for monitoring and controlling AMR in agricultural settings.
TEM,CTX-M,SHV Genes in ESBL-Producing Escherichia coli and Klebsiella pneumoniae Isolated from Clinical Samples in a County Clinical Emergency Hospital Romania-Predominance of CTX-M-15.
The study identifies the prevalence of bla CTX-M-15, bla SHV-1, and bla TEM-1 genes in ESBL-producing E. coli and K. pneumoniae isolates, highlighting the dominance of CTX-M-15. It also detects tetracycline resistance genes tet(A) and tet(B).
Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017.
The study identified several AMR genes in K. pneumoniae isolates, including bla CTX-M-15, bla SHV-27, bla SHV-1, bla SHV-101, bla SHV-108, bla TEM-1B, qnrB66, aac(3)-IIa, dfrA14, strA, strB, sul2, and tet(A). These genes conferred resistance to various antibiotics such as beta-lactams, quinolones, aminoglycosides, sulfonamides, and tetracyclines.
Genetic Characterization of Four Groups of Chromosome-Borne Accessory Genetic Elements Carrying Drug Resistance Genes in Providencia.
This study characterizes four groups of chromosome-borne accessory genetic elements (AGEs) in Providencia, highlighting the diversity and complexity of multidrug resistance (MDR) regions within these elements. It identifies numerous drug resistance genes, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and others, contributing to the understanding of AMR mechanisms in Providencia.
Multidrug Resistance Genes Carried by a Novel Transposon Tn7376 and a Genomic Island Named MMGI-4 in a Pathogenic Morganella morganii Isolate.
The study identifies a novel transposon Tn7376 and a genomic island MMGI-4 in a multidrug-resistant Morganella morganii isolate, carrying multiple antimicrobial resistance genes including dfrA24, mph(A), aadA1, sul1, floR, catA2, cmlA1, aph(3')-Ia, aac(6')-Ib-cr, tet(A), tet(B), arr-3, blaTEM-1B, blaDHA-17, blaCARB-2, blaOXA-1, blaCTX-M-3, and fosA3.
Natural transformation allows transfer of SCCmec-mediated methicillin resistance in Staphylococcus aureus biofilms.
The study demonstrates that natural transformation in biofilms enables the transfer of SCCmec-mediated methicillin resistance in Staphylococcus aureus, highlighting the role of TCS13 and TCS17 in regulating competence and transformation efficiency.
Characterization of multi-resistant Shigella species isolated from raw cow milk and milk products.
The study identified multiple antibiotic resistance genes in Shigella species isolated from raw cow milk and milk products in Egypt, including blaTEM, blaCTX-M, tet(A), and qacEdelta1. These genes conferred resistance to various antibiotics and disinfectants, highlighting the emergence of multidrug-resistant Shigella strains.
Characterization of qnrB-carrying plasmids from ESBL- and non-ESBL-producing Escherichia coli.
The study characterized qnrB-carrying plasmids from ESBL- and non-ESBL-producing E. coli, identifying qnrB1, qnrB2, and qnrB19 as major quinolone resistance determinants. These plasmids were found to be self-transmissible and associated with various resistance genes.
Emergence of a Hypervirulent Tigecycline-Resistant Klebsiella pneumoniae Strain Co-producing bla (NDM-1) and bla (KPC-2) With an Uncommon Sequence Type ST464 in Southwestern China.
The study reports on a hypervirulent tigecycline-resistant Klebsiella pneumoniae strain (AHSWKP25) co-producing bla(NDM-1) and bla(KPC-2) with an unusual sequence type ST464 in Southwestern China. The strain exhibits extensive drug resistance, including resistance to tigecycline, and possesses mutations in genes related to efflux pump regulation and outer membrane porins.
Studies on the Transmission of a Tigecycline Resistance-Mediating tet(A) Gene Variant from Enterobacter hormaechei via a Two-Step Recombination Process.
The study identifies a tet(A) gene variant that confers resistance to tigecycline in Enterobacter hormaechei and describes the two-step recombination process facilitating its transfer between plasmids.
Submarine Outfalls of Treated Wastewater Effluents are Sources of Extensively- and Multidrug-Resistant KPC- and OXA-48-Producing Enterobacteriaceae in Coastal Marine Environment.
The study identified extensively drug-resistant (XDR) and multidrug-resistant (MDR) KPC- and OXA-48-producing Enterobacteriaceae in coastal marine environments, highlighting the presence of various AMR genes including bla KPC-2, bla OXA-48, and others.
Genomic Analysis of Multidrug-Resistant Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Strain Lacking the Hypermucoviscous Regulators (rmpA/rmpA2).
The study identified multiple antimicrobial resistance genes in a multidrug-resistant hypervirulent Klebsiella pneumoniae strain, including beta-lactamases, sulfonamide resistance genes, fosfomycin resistance genes, aminoglycoside resistance genes, and tetracycline resistance genes.
KPC-3-, GES-5-, and VIM-1-Producing Enterobacterales Isolated from Urban Ponds.
The study identified bla KPC-3, bla GES-5, and bla VIM genes in various Enterobacterales isolates from urban ponds, highlighting their role in carbapenem resistance.
Genomic Characterization of an O101:H9-ST167 NDM-5-Producing Escherichia coli Strain from a Kitten in Italy.
The study characterizes an NDM-5-producing Escherichia coli ST167 strain from a kitten in Italy, highlighting the presence of multiple AMR genes including blaNDM-5, bla_ble, blaAmpH, blaAmpC1, and others, along with mutations in gyrA, parC, and parE contributing to fluoroquinolone resistance.
KPC-3-Producing Klebsiella pneumoniae Sequence Type 392 from a Dog's Clinical Isolate in Portugal.
The study characterizes a KPC-3-producing Klebsiella pneumoniae ST392 isolate from a dog in Portugal, highlighting the presence of multiple AMR genes including blaKPC-3, aac(6')-lb-cr, tet(A), sul2, qnrB1, and OqxB/A, indicating multidrug resistance.
mcr-1-Mediated Colistin Resistance and Genomic Characterization of Antimicrobial Resistance in ESBL-Producing Salmonella Infantis Strains from a Broiler Meat Production Chain in Italy.
The study identified mcr-1.1 and mcr-1.2 variants on IncX4 plasmids in colistin-resistant Salmonella Infantis strains, along with other resistance genes such as blaCTX-M-1, aac(6')-Iaa, tet(A), dfrA1, sul1, and qacE.
Characterization of β-Lactamases and Multidrug Resistance Mechanisms in Enterobacterales from Hospital Effluents and Wastewater Treatment Plant.
The study identified several β-lactamase genes, including bla CTX-M-27, bla TEM-1, bla CTX-M-15, bla CTX-M-30, and bla SHV-12, along with a variety of other AMR genes such as aadA5, aph(3''-Ib), aph(6)-Id, aac(3)-IIa, sul1, sul2, dfrA17, dfrA14, qnrB1, tet(A), mph(A), qacE∆, and catB3, which confer resistance to various antibiotics in Enterobacterales isolated from hospital effluents and wastewater treatment plants.
Genomic Analysis of Two MDR Isolates of Salmonella enterica Serovar Infantis from a Spanish Hospital Bearing the bla(CTX-M-65) Gene with or without fosA3 in pESI-like Plasmids.
The study reports two multidrug-resistant (MDR) isolates of Salmonella enterica serovar Infantis from Spain carrying the blaCTX-M-65 gene on pESI-like plasmids, along with other resistance genes such as floR, aac(3)-IVa, aph(3′)-Ia, aph(4)-Ia, aadA1, tet(A), sul1, dfrA14, and fosA3. Mutations in gyrA and parC were associated with fluoroquinolone resistance, while truncations in nsfA and nsfB were linked to nitrofurantoin resistance.
Genome analysis and virulence gene expression profile of a multi drug resistant Salmonella enterica serovar Typhimurium ms202.
The study identified multiple antimicrobial resistance genes in the multi-drug resistant Salmonella enterica serovar Typhimurium ms202 strain, including fosA7, sul1, aadA7, aac(6')-laa, tet(A), and qacE, which confer resistance to various antibiotics such as fosfomycin, sulfamethoxazole, spectinomycin, amikacin, tetracycline, and disinfectants.
Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches.
The study identifies several AMR genes and mutations associated with resistance to various antibiotics in wastewater environments, highlighting the role of these genes in the spread of antimicrobial resistance.
Biofilm Formation and Antimicrobial Susceptibility of E. coli Associated With Colibacillosis Outbreaks in Broiler Chickens From Saskatchewan.
The study identified several AMR genes in E. coli isolates from broiler chickens in Saskatchewan, including genes conferring resistance to tetracyclines, sulfonamides, trimethoprim, aminoglycosides, and beta-lactam antibiotics. Additionally, a multi-drug efflux pump gene (mdfA) was identified.
Clustered Regularly Interspaced Short Palindromic Repeats Genotyping of Multidrug-Resistant Salmonella Heidelberg Strains Isolated From the Poultry Production Chain Across Brazil.
The study identified several AMR genes and chromosomal mutations in multidrug-resistant Salmonella Heidelberg strains isolated from the poultry production chain in Brazil, highlighting the widespread distribution of antibiotic-resistant strains.
Genomic and Evolutionary Analysis of Salmonella enterica Serovar Kentucky Sequence Type 198 Isolated From Livestock In East Africa.
The study identified multiple antimicrobial resistance genes in Salmonella enterica serovar Kentucky ST198 isolates from East Africa, including aac(3)-Id, aadA7, strA, strB, bla TEM-1B, sul1, and tet(A), which confer resistance to aminoglycosides, streptomycin, ampicillin, sulfamethoxazole, and tetracycline. Mutations in gyrA and parC were associated with ciprofloxacin resistance.
Longitudinal study on background lesions in broiler breeder flocks and their progeny, and genomic characterisation of Escherichia coli.
The study identified several AMR genes in E. coli isolates, including mdfA, sitABCD, blaTEM1B, sul2, dfrA1, tet(A), aadA1, and qnrS1, which conferred resistance to multidrug, beta-lactams, sulfonamides, trimethoprim, tetracycline, aminoglycosides, and quinolones.
A plasmid network from the gut microbiome of semi-isolated human groups reveals unique and shared metabolic and virulence traits.
The study identifies plasmids in the gut microbiomes of semi-isolated human groups, including resistance genes such as aph, tet, tem, and dfrf, which confer resistance to aminoglycosides, tetracyclines, beta-lactams, and trimethoprim, respectively.
First Report of bla (CTX-M-167), bla (SHV-1), and bla (TEM-1B) Carrying Klebsiella pneumonia Showing High-Level Resistance to Carbapenems.
The study identifies the first report of a carbapenem-resistant Klebsiella pneumoniae strain carrying bla CTX-M-167, bla TEM-1B, and bla SHV-1, along with other resistance genes such as qnrS1, aac(6')-1b-cr, aadA16, tet(A), fosA, sul1, and mph(A).
Virulence Profiling, Multidrug Resistance and Molecular Mechanisms of Campylobacter Strains from Chicken Carcasses in Tunisia.
The study identified multiple AMR genes and mutations in Campylobacter strains from chicken carcasses in Tunisia, highlighting the presence of multidrug-resistant strains with high resistance rates to various antibiotics.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Serotype Diversity and Antimicrobial Resistance Profile of Salmonella enterica Isolates From Freshwater Turtles Sold for Human Consumption in Wet Markets in Hong Kong.
The study identifies the multidrug-resistance gene cfr for the first time in Salmonella, highlighting the expansion of the cfr reservoir and potential horizontal spread to other bacteria. It also detects various AMR genes such as floR, sul2, aph(3')-Ia, aph(3”)-Ib, aph(6)-Id, aac(6')-Ib-cr, bla CMY−2, bla TEM−1, qnrS1, erm(B), mph(E), msr(E), qepA8, arr-3, sul1, dfrA12, dfrA27, tet(A), tet(D), catB3, aadA16, aac(3)-IV, aph(4)-Ia, aadA2, and fosA7.
Whole-genome sequencing-based prediction and analysis of antimicrobial resistance in Yersinia enterocolitica from Ningxia, China.
The study identified several AMR genes in Yersinia enterocolitica isolates from Ningxia, China, including aph(6)-Id, aph(3")-Ib, sul2, tet(A), tet(Y), and y56, which confer resistance to various antibiotics such as ampicillin, streptomycin, trimethoprim/sulfamethoxazole, tetracycline, and others. These genes were validated through whole-genome sequencing and resistance gene prediction.
Large-Scale Studies on Antimicrobial Resistance and Molecular Characterization of Escherichia coli from Food Animals in Developed Areas of Eastern China.
The study identified mcr-1, tet(X4), and blaNDM-5 genes in Escherichia coli from food animals in eastern China, highlighting their role in resistance to colistin, tigecycline, and meropenem, respectively. These genes were found to be transferable via plasmids, emphasizing the potential for spread of antimicrobial resistance.
Within-farm dynamics of ESBL-producing Escherichia coli in dairy cattle: Resistance profiles and molecular characterization by long-read whole-genome sequencing.
The study identified multiple ESBL-encoding genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, and bla SHV-12, as well as carbapenemase gene bla NDM-1, in ESBL-producing E. coli isolates from dairy cattle farms. These genes were associated with resistance to various beta-lactam antibiotics. Additionally, several other AMR genes such as aadA2, ant(3")-Ia, aph(3')-Ia, dfrA12, sul3, cmlA1, and others were identified, contributing to resistance against aminoglycosides, trimethoprim, sulfamethoxazole, and chloramphenicol. Mutations in gyrA, parC, and parE were linked to fluoroquinolone resistance.
Emergence of a Novel NDM-5-Producing Sequence Type 4523 Klebsiella pneumoniae Strain Causing Bloodstream Infection in China.
The study identifies a novel sequence type 4523 Klebsiella pneumoniae strain, ST4523, which is resistant to multiple antibiotics, including carbapenems, and carries the bla NDM-5 gene on a plasmid. The strain also possesses various other resistance genes on plasmids pSHX180-1 and pSHX180-NDM5.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
High Prevalence of Beta-Lactam-Resistant Escherichia coli in South Australian Grey-Headed Flying Fox Pups (Pteropus poliocephalus).
The study identified various beta-lactam-resistant Escherichia coli strains in South Australian grey-headed flying fox pups, including resistance genes such as blaTEM-1B, blaTEM-1C, blaTEM-33, blaCMY-2, dfrA17, aadA5, dfrA5, sul2, tet(A), tet(B), and catA1.
Tigecycline-resistant Escherichia coli ST761 carrying tet(X4) in a pig farm, China.
The study identifies tet(X4) as a major cause of tigecycline resistance in E. coli ST761 isolates from a pig farm in China. The gene is located on a hybrid plasmid and is part of a multidrug resistance region that includes other resistance genes such as blaTEM-1, tet(A), tet(M), floR, qnrS1, sul3, dfrA5, and mef(B).
Effects of Nutrient Level and Growth Rate on the Conjugation Process That Transfers Mobile Antibiotic Resistance Genes in Continuous Cultures.
The study identifies the tetracycline resistance genes tet(A) and tet(R) transferred via plasmids from wastewater treatment plant effluent to river bacteria, demonstrating increased resistance levels in transconjugants.
Molecular characterization and biofilm-formation analysis of Listeria monocytogenes, Salmonella spp., and Escherichia coli isolated from Brazilian swine slaughterhouses.
The study identified various antimicrobial resistance genes in E. coli and Salmonella Typhi isolates from Brazilian swine slaughterhouses, including ampC, blaSHV, cat1, clmA, MCR-1, MCR-3, tet(A), tet(B), tet(C), tet(M), and sulI. These genes conferred resistance to multiple antibiotics such as ampicillin, amoxicillin, chloramphenicol, tetracycline, doxycycline, colistin, and sulfonamide.
Genomic Analysis of Shiga Toxin-Producing E. coli O157 Cattle and Clinical Isolates from Alberta, Canada.
The study identified eight antimicrobial resistance gene cassettes (ARCs) in 14 isolates, with streptomycin resistance genes (aadA1, aadA2, ant(3'')-Ia, and aph(3'')-Ib) being the most prevalent. Other resistance genes included sul1, sul2, tet(A), tet(B), and beta-lactam resistance genes (blaTEM-1B and blaTEM-1C).
Occurrence of Antimicrobial-Resistant Escherichia coli in Marine Mammals of the North and Baltic Seas: Sentinels for Human Health.
The study identified antimicrobial-resistant Escherichia coli in marine mammals from the North and Baltic Seas, highlighting the presence of resistance genes such as blaTEM, strA, strB, aadA1, sul1, sul2, tet(A), tet(B), tet(D), qnrS, floR, catA1, blaOXA-1-like, blaSHV, and blaCMY-2.
Low levels of tetracyclines select for a mutation that prevents the evolution of high-level resistance to tigecycline.
The study identifies a tet(A) delta tetR allele with a 24-bp deletion in tetR(A) that prevents tigecycline resistance development through gene amplification. This mutation reduces the induction of tetA(A) expression, limiting the ability of E. coli to develop high-level tigecycline resistance.
Antimicrobial resistance and genomic investigation of non-typhoidal Salmonella isolated from outpatients in Shaoxing city, China.
Acquisition of genomic elements were pivotal for the success of Escherichia coli ST410
The study identified several AMR genes and mutations in Escherichia coli ST410, including bla OXA-181, bla NDM-5, bla CTX-M-15, and mutations in gyrA, parC, and parE that confer resistance to carbapenems, cephalosporins, penicillins, aminoglycosides, sulfonamides, trimethoprim, and fluoroquinolones.
Emergence of a Fatal ST11-KL64 Tigecycline-Resistant Hypervirulent Klebsiella pneumoniae Clone Cocarrying bla(NDM) and bla(KPC) in Plasmids.
The study identifies a tigecycline-resistant ST11-KL64 hypervirulent Klebsiella pneumoniae isolate that co-carries bla(KPC) and bla(NDM) genes, leading to multidrug resistance and a fatal blood infection.
Sequencing analysis of tigecycline resistance among tigecycline non-susceptible in three species of G-ve bacteria isolated from clinical specimens in Baghdad.
The study identified the presence of tet(A) and tet(B) genes in tigecycline non-susceptible isolates of Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa, highlighting their role in tigecycline resistance.
Genome-associations of extended-spectrum ß-lactamase producing (ESBL) or AmpC producing E. coli in small and medium pig farms from Khon Kaen province, Thailand.
The study identifies various AMR genes in ESBL and/or AmpC-producing E. coli from small and medium pig farms in Thailand, highlighting the co-occurrence of resistance genes conferring resistance to critically important antimicrobials.
Emergence of a Novel Lineage and Wide Spread of a bla(CTX-M-15)/IncHI2/ST1 Plasmid among Nosocomial Enterobacter in Guadeloupe.
The study identifies the bla CTX-M-15 gene as the most prevalent ESBL determinant in ESBL-producing Enterobacter cloacae complex isolates, along with the IncHI2/ST1 plasmid. It also reports the presence of other resistance genes such as mcr-9, aac(3)-IIa, aac(6′)-Ib-cr, aph(3″)-Ib, aph(6)-Id, bla OXA-1, bla TEM-1B, qnrB1, fosA, sul2, tet(A), dfrA14, ars, mer, tni, and the ter operon.
Microbial Diversity and Pathogenic Properties of Microbiota Associated with Aerobic Vaginitis in Women with Recurrent Pregnancy Loss.
The study identified several AMR genes, including erm, tet, aac(6')-Ib, and vanA, in bacteria associated with aerobic vaginitis in women with recurrent pregnancy loss. These genes conferred resistance to various antibiotics such as erythromycin, tetracycline, kanamycin, gentamicin, and vancomycin.
Isolation of extended-spectrum β-lactamase-producing Escherichia coli from Japanese red fox (Vulpes vulpes japonica).
Two CTX-resistant Escherichia coli strains were isolated from Japanese red fox fecal samples, harboring various AMR genes and mutations. One strain carried aph(3")-Ib, aph(3')-Ia, aph(6)-Id, mdf(A), sitABCD, sul2, tet(A), and tet(B), while the other had gyrA(S83L), parC(S80I, E84V), and parE(I529L) mutations along with mdf(A) and sitABCD.
Coexistence of tet(A) and bla(KPC-2) in the ST11 hypervirulent tigecycline- and carbapenem-resistant Klebsiella pneumoniae isolated from a blood sample.
The study identifies the coexistence of the tet(A) gene and bla(KPC-2) in a hypervirulent tigecycline- and carbapenem-resistant ST11 Klebsiella pneumoniae strain, XJ-K2, isolated from a blood sample in China.
Multistate reptile- and amphibian-associated salmonellosis outbreaks in humans, United States, 2009-2018.
The study identified various AMR genes and mutations in Salmonella isolates from multistate reptile- and amphibian-associated salmonellosis outbreaks in the United States, including bla CMY-2, qnrB19, qnrS1, bla TEM-116, bla TEM-1C, bla TEM-1B, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, sul1, sul3, floR, tet(A), and sul2, which conferred resistance to multiple antibiotics such as ciprofloxacin, ceftriaxone, ampicillin, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline.
Genomic Characterization of an Extensively Drug-Resistant Extra-Intestinal Pathogenic (ExPEC) Escherichia coli Clinical Isolate Co-Producing Two Carbapenemases and a 16S rRNA Methylase.
The study describes an extensively drug-resistant (XDR) E. coli ST361 isolate co-carrying bla KPC-3, bla NDM-5, and various other resistance genes on multiple plasmids, showing resistance to nearly all antibiotics except tigecycline, colistin, and fosfomycin.
Genomic Study of Chromosomally and Plasmid-Mediated Multidrug Resistance and Virulence Determinants in Klebsiella Pneumoniae Isolates Obtained from a Tertiary Hospital in Al-Kharj, KSA.
The study identified several AMR genes in K. pneumoniae isolates, including blaOXA-1, blaCTX-M-3, blaOXA-232, catB3, aac(6')-Ib-cr, dfrA14, IntI1, IS1, RepE, qnrB4, qnrB55, qnrS1, aph(3")-Ib, sul2, aadA2, SHV-190, SHV-26, SHV-11, tet(A), fosA, OqxA, and OqxB, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, trimethoprim, quinolones, sulfonamides, and fosfomycin.
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
The study identified ESBL-producing E. coli in river water in northern Thailand, with bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27 being the most prevalent beta-lactamase genes. Additionally, mcr-1.1 and mcr-3.4 genes were found to confer resistance to colistin. Various other resistance genes were also characterized, including aac(3)-IId, aadA5, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, aac(6′)-Ib-cr, qnrS1, mdf(A), erm(B), mph(A), floR, sul2, sul3, tet(A), tet(X), tet(M), dfrA12, dfrA14, dfrA17, cmlA1, catA2, lnu(F), and erm(42).
Molecular Characterization and the Antimicrobial Resistance Profile of Salmonella spp. Isolated from Ready-to-Eat Foods in Ouagadougou, Burkina Faso.
The study identified several antimicrobial resistance genes in Salmonella isolates from ready-to-eat foods in Burkina Faso, including blaTEM, temB, sul1, sul2, aadA, tet(A), and tet(B). These genes confer resistance to various antibiotics such as ampicillin, cefoxitin, trimethoprim/sulfamethoxazole, and tetracycline.
Can Stray Cats Be Reservoirs of Antimicrobial Resistance?
Stray cats can carry antibiotic-resistant E. coli with resistance genes blaTEM, blaCTX-M, tet(A), and tet(B), indicating their potential role in the spread of antimicrobial resistance in urban environments.
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
Establishing a marine monitoring programme to assess antibiotic resistance: A case study from the Gulf Cooperation Council (GCC) region.
The study identified several AMR genes in E. coli isolates from the GCC marine environment, including bla TEM-1, bla CTX-M-15, qnrS1, tet, sul, and dfr, which conferred resistance to various antibiotics such as ampicillin, cefotaxime, ceftazidime, ciprofloxacin, tetracycline, sulfamethoxazole, and trimethoprim.
The hazard of carbapenemase (OXA-181)-producing Escherichia coli spreading in pig and veal calf holdings in Italy in the genomics era: Risk of spill over and spill back between humans and animals.
The study identifies multiple AMR genes, including bla OXA-181, bla TEM-1B, aac (3)-IId, aad A2, cml A1, dfr A12, mef (B), sul 3, tet (A), tet (M), incX3, incX1, incFII, qnr S1, aph (3″)-Ib, aph (6)-Id, flo R, lnu (F), sul 2, sul 3, tet (B), mph (A), mph (G), qnr B4, rmt B, and fos A3, in OXA-181-producing E. coli isolates from pigs and bovines in Italy. These genes confer resistance to various antibiotics, including carbapenems, cephalosporins, penicillins, aminoglycosides, trimethoprim, macrolides, sulfonamides, tetracyclines, fluoroquinolones, and fosfomycin.
Coexistence of Multidrug Resistance and Virulence in a Single Conjugative Plasmid from a Hypervirulent Klebsiella pneumoniae Isolate of Sequence Type 25.
The study identifies a conjugative plasmid pCY814036-iucA carrying multidrug resistance genes and virulence factors, and another plasmid pCY814036-KPC2 harboring bla KPC-2 and rmtB, contributing to carbapenem resistance and hypervirulence in a Klebsiella pneumoniae isolate.
A sludge bulking wastewater treatment plant with an oxidation ditch-denitrification filter in a cold region: bacterial community composition and antibiotic resistance genes.
The study identified several antibiotic resistance genes (ARGs) in a sludge bulking wastewater treatment plant, including sul1, aadA5, ErmF, tet(A), and msrE, which confer resistance to sulfonamide, aminoglycoside, macrolide, tetracycline, and other antibiotics.
Mobile colistin resistance (MCR), extended-spectrum beta-lactamase (ESBL) and multidrug resistance monitoring in Escherichia coli (commensal and pathogenic) in pig farming: need of harmonized guidelines and clinical breakpoints.
The study identified mcr-1 and mcr-4 genes conferring colistin resistance, along with blaTEM-1B, aph(3")-Ib, aph(6)-Id, sul2, and tet(A) genes responsible for resistance to various antibiotics in E. coli isolates from pig farming.
Identification of a Multidrug Resistant Pseudomonas aeruginosa Isolate Harboring Infrequent Red Fluorescence Plasmid from COPD Patient.
The study identifies a multidrug-resistant Pseudomonas aeruginosa isolate L1a harboring an infrequent red fluorescence plasmid. The isolate shows resistance to several antibiotics including levofloxacin, cefepime, aztreonam, and imipenem, and carries multiple drug resistance genes and efflux pump-related genes.
Rothia nasimurium as a Cause of Disease: First Isolation from Farmed Chickens.
Rothia nasimurium was isolated from chickens for the first time and found to exhibit multidrug resistance, carrying 13 resistance genes including bla TEM, bla CTX-M, mecA, sul1, sul2, sul3, aac(6′)-Ib, gyrA, aph(3′)-Ia, tet(A), tetM, and ermB.
First Report of Potentially Pathogenic Klebsiella pneumoniae from Serotype K2 in Mollusk Tegillarca granosa and Genetic Diversity of Klebsiella pneumoniae in 14 Species of Edible Aquatic Animals.
The study reports the presence of tetracycline resistance in Klebsiella pneumoniae isolates from various aquatic animals, highlighting the potential risk of antimicrobial resistance in food sources.
Intestinal colonization with ESBL-producing Klebsiella pneumoniae in healthy rural villager: A genomic surveillance study in China, 2015-2017.
The study identified multiple ESBL genes, including bla TEM-1B, bla CTX-M-14, and bla SHV-11, along with other resistance genes such as qnrS1, sul1, aac(6')-Ib-cr, aadA16, aph(3')-Ib, tet(A), and mcr-1, contributing to multidrug resistance in ESBL-producing Klebsiella pneumoniae isolates from healthy rural villagers in China.
Resistome and virulome diversity of foodborne pathogens isolated from artisanal food production chain of animal origin in the Mediterranean region.
The study identified various AMR genes in L. monocytogenes, Salmonella enterica, and S. aureus isolates from artisanal food production chains in the Mediterranean region, highlighting the presence of fosfomycin, aminoglycoside, beta-lactam, trimethoprim, sulfonamide, tetracycline, and streptomycin resistance mechanisms.
Genomic Characterization of ESBL/AmpC-Producing Escherichia coli in Stray Dogs Sheltered in Yangzhou, China.
The study identified several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-55, and others, along with additional resistance genes such as tet(A), qnrS1, and oqxAB, contributing to multidrug resistance in ESBL/AmpC-producing E. coli isolated from stray dogs in Yangzhou, China.
Age influences the temporal dynamics of microbiome and antimicrobial resistance genes among fecal bacteria in a cohort of production pigs.
The study identified the presence of tetracycline resistance gene tet(A) and extended-spectrum beta-lactamase gene blaCTX-M in fecal bacteria of pigs, with their abundance decreasing as pigs aged.
Salmonella Heidelberg and Salmonella Minnesota in Brazilian broilers: Genomic characterization of third-generation cephalosporin and fluoroquinolone-resistant strains.
The study identifies multiple AMR genes and mutations in Salmonella Heidelberg and Salmonella Minnesota isolates from Brazilian broilers, including bla CMY-2, qnrB19, aac(6')-Iaa, sul2, tet(A), fosA7, qacE, and formA, along with gyrA(S83F) and parC(T57S) mutations conferring resistance to various antibiotics.
Molecular and Clinical Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Isolates at a Tertiary Hospital in Wuhan, China.
The study identified multiple carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates carrying various resistance genes, including blaKPC-1, blaCTX-M-65, blaTEM-1, blaSHV-182, rmtB, aadA2, APH(3')-Ia, sul1, sul2, QnrS1, mphA, FosA6, floR, and tet(A). These genes confer resistance to carbapenems, beta-lactams, aminoglycosides, sulfonamides, fluoroquinolones, macrolides, fosfomycin, chloramphenicol, and tetracyclines.
Isolation, Identification and Genetic Characterization of Antibiotic Resistant Escherichia coli from Frozen Chicken Meat Obtained from Supermarkets at Dhaka City in Bangladesh.
The study identified several antimicrobial resistance genes in E. coli isolates from frozen chicken meat, including tet(A), tet(B), aadA1, aac(3)-IV, ereA, blaCITM, blaSHV, sulI, catA1, and cmlA, which confer resistance to tetracycline, streptomycin, gentamicin, erythromycin, ampicillin, sulfonamide, and chloramphenicol.
Conjugation of plasmid harboring bla (NDM-1) in a clinical Providencia rettgeri strain through the formation of a fusion plasmid.
The study identifies multiple AMR genes, including blaNDM-1, blaOXA-10, blaPER-4, aph(3')-VI, ant(2'')-Ia, ant(3')-Ia, sul1, catB8, catA1, mph(E), and tet, in a multidrug-resistant Providencia rettgeri strain. These genes contribute to resistance against various antibiotics, including carbapenems, beta-lactams, aminoglycosides, sulfonamides, chloramphenicol, macrolides, and tetracyclines.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
In silico analyses of diversity and dissemination of antimicrobial resistance genes and mobile genetics elements, for plasmids of enteric pathogens.
The study identifies a diverse array of antimicrobial resistance (AMR) genes across various plasmid replicon types in enteric pathogens, highlighting the prevalence of resistance genes in plasmids such as IncHI2, IncN, IncA/C, IncP, IncHI1, and IncFIA. Key AMR genes include aac(3)-IId, aac(3)-IIg, aac(6')-Ib3, aadA1, aadA5, aph(3'')-Ib, bla CMY-2, bla CTX-M-27, bla NDM-1, mcr-9.1, and others, which confer resistance to antibiotics such as gentamicin, cephalosporins, carbapenems, colistin, and tetracycline.
Emergence of high-level colistin resistance mediated by multiple determinants, including mcr-1.1, mcr-8.2 and crrB mutations, combined with tigecycline resistance in an ST656 Klebsiella pneumoniae.
The study reports a highly drug-resistant ST656 Klebsiella pneumoniae strain, KP15-652, exhibiting high-level colistin resistance mediated by mcr-1.1, mcr-8.2, and crrB mutations, alongside tigecycline resistance conferred by tmexCD1-toprJ1, tet(A), and tet(M).
Systematic In Silico Assessment of Antimicrobial Resistance Dissemination across the Global Plasmidome.
The study identifies various antimicrobial resistance genes (ARGs) and their dissemination patterns across the global plasmidome using %GC content analysis. Key findings include the identification of genes such as sul, dfrA, qnr, CTX-M, OXA, APH(3'), ANT(3''), AAC(6'), mcr, erm, tet, and qac, which are associated with resistance to sulfonamides, trimethoprim, quinolones, beta-lactams, aminoglycosides, polymyxins, macrolides, lincosamides, streptogramins, tetracyclines, and quaternary ammonium compounds.
Characterization of NDM-5-Producing Escherichia coli Strains Isolated from Pediatric Patients with Bloodstream Infections in a Chinese Hospital.
The study characterizes NDM-5-producing E. coli strains isolated from pediatric patients with bloodstream infections in a Chinese hospital, identifying various beta-lactamase genes and tetracycline resistance genes contributing to multidrug resistance.
Characterization of Extensively Drug-Resistant Salmonella enterica Serovar Kentucky Sequence Type 198 Isolates from Chicken Meat Products in Xuancheng, China.
Extensively drug-resistant Salmonella enterica serovar Kentucky ST198 isolates from chicken meat products in Xuancheng, China, were characterized. These isolates carried multiple resistance genes, including bla CTX-M-55, bla TEM-1B, aac(3)-IId, aadA17, rmtB, tet(A), floR, lnu(F), arr-2, qnrS1, sul1, mph(A), and fosA3, and mutations in gyrA (S83F, D87N) and parC (S80I), leading to resistance against several antimicrobial agents.
Antimicrobial resistance profiles of Campylobacter jejuni and Salmonella spp. isolated from enteritis patients in Japan.
The study identified several AMR genes including blaCMY-2, aac(6')-Iaa, ant(3")-Ib, aph(6)-Id, floR, qnrB19, sul2, and tet(A) in cefotaxime-resistant Salmonella isolates. Additionally, mutations in the gyrA gene, specifically Thr86Ile, were found in ciprofloxacin-resistant C. jejuni isolates.
Epidemiological characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic analysis of Aeromonas caviae isolated from extra-intestinal infections.
The study identified multiple antimicrobial resistance genes in Aeromonas caviae isolates from extra-intestinal infections, including blaMOX, blaPER-3, blaOXA, blaNDM, blaCphA, qnrS2, qnrVC, aac(6')-Ib-cr, tet(A), tet(E), tet(31), dfrA1, dfrA12, dfrA14, dfrA15b, floR, catB3, catII, and catI, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, tetracyclines, trimethoprim, and chloramphenicol.
Genomic analyses of drug-resistant Salmonella enterica serovar Heidelberg strains isolated from meat and related sources between 2013 and 2017 in the south region of Brazil.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella enterica serovar Heidelberg strains, including fosA7, aac(6')-Iaa, sul2, tet(A), bla CMY-2, mdsA, mdsB, and point mutations in gyrA and parC, indicating a multidrug-resistant profile.
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.
The study identified various AMR genes in sepsis-causing bacteria, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others, highlighting the complexity of AMR in these pathogens.
Antibiotics and Bacterial Resistance-A Short Story of an Endless Arms Race.
The paper discusses the mechanisms of antibiotic actions and bacterial resistance strategies, highlighting the challenges posed by multidrug-resistant microbes and the need for new antimicrobial agents.
Genomic Diversity, Antimicrobial Susceptibility, and Biofilm Formation of Clinical Acinetobacter baumannii Isolates from Horses.
The study identified multiple AMR genes in equine Acinetobacter baumannii isolates, including beta-lactamases (bla OXA-51-like, bla ADC-25, bla TEM-1D), sulfonamide resistance genes (sul1, sul2), chloramphenicol resistance genes (catA1, ABUW 0982), tetracycline resistance genes (tet(A), tet(B), tet(39)), and aminoglycoside modifying enzymes (aph(3′)-Ia, aph(3`)-Ic, aph(6)-Id, aac(3)-Ia). Additionally, eight novel OXA-51-like variants (OXA-970 to OXA-977) were characterized.
Association of ISVsa3 with Multidrug Resistance in Salmonella enterica Isolates from Cattle (Bos taurus).
The study found that multidrug resistance (MDR) in Salmonella enterica isolates from cattle is strongly associated with the presence of IS Vsa3, an IS91-like transposase. The MDR genes, including floR, tet(A), aph(6)-Id, aph(3"-Ib, sul2, and bla CMY-2, were often located on IncC plasmids carrying IS Vsa3.
Antimicrobial Resistance in Vaginal Bacteria in Inseminated Mares.
The study identified several AMR genes in E. coli, S. equisimilis, and S. simulans, including sul1, sul2, dfrA1, dfrA14, tet(A), mdf(A), blaEC-5, blaTEM-1, blaTEM-1B, blaEC, catB3, aadA5, aph(6)-ld, lsaC, and blaZ, which conferred resistance to various antibiotics.
Mobile genetic elements drive the multidrug resistance and spread of Salmonella serotypes along a poultry meat production line.
The study identifies multiple antimicrobial resistance genes in Salmonella isolates from a poultry production line, highlighting the role of mobile genetic elements in the spread of multidrug resistance.
In vivo adaptive antimicrobial resistance in Klebsiella pneumoniae during antibiotic therapy.
The study identifies several AMR genes and mutations in Klebsiella pneumoniae that contribute to resistance against carbapenems, ceftazidime/avibactam, tigecycline, and colistin. Key findings include the acquisition of blaKPC and blaNDM harboring plasmids, specific mutations in blaKPC, porin deficiencies (ompK35 and ompK36), overexpression of efflux pumps (acrAB, oqxAB), and mutations in rpsJ, ramR, tetA, mgrB, and pmrB.
Comparison of antimicrobial resistance among Salmonella enterica serovars isolated from Canadian turkey flocks, 2013 to 2021.
The study identified high levels of resistance to streptomycin, sulfisoxazole, and tetracycline among Salmonella enterica serovars isolated from Canadian turkey flocks. Key serovars included S. Uganda, S. Hadar, and S. Reading, with S. Uganda showing the highest multidrug resistance.
Antimicrobial susceptibility test and antimicrobial resistance gene detection of extracellular enzyme bacteria isolated from tilapia (Oreochromis niloticus) for probiotic candidates.
The study identified tetracycline resistance genes (tet(A), tet(B), tet(E)) and a quinolone resistance gene (qnr(S)) in extracellular enzyme-producing bacteria isolated from tilapia, highlighting the need for careful selection of probiotic candidates to avoid antibiotic resistance dissemination.
Prevalence and Genomic Characteristics of mcr-Positive Escherichia coli Strains Isolated from Humans, Pigs, and Foods in China.
The study identified mcr-1 as a major gene conferring colistin resistance in Escherichia coli isolates from humans, pigs, and foods in China. Additionally, several other resistance genes such as tet(A), floR, sul2, aadA1, strA, strB, blaCTX-M-14, fosA, lnu(F), and arr-3 were found to confer resistance to various antibiotics.
High Genetic Diversity of Carbapenem-Resistant Acinetobacter baumannii Isolates Recovered in Nigerian Hospitals in 2016 to 2020.
The study identified blaOXA-23 and blaNDM-1 as the most common carbapenem resistance genes in Acinetobacter baumannii isolates from Nigerian hospitals, along with several other AMR genes and mutations contributing to multidrug resistance.
Brevundimonas brasiliensis sp. nov.: a New Multidrug-Resistant Species Isolated from a Patient in Brazil.
The study characterizes Brevundimonas brasiliensis sp. nov., a novel species isolated from a neonatal intensive care unit, and identifies several antimicrobial resistance genes and mutations associated with resistance to β-lactams, aminoglycosides, fluoroquinolones, and colistin.
Efflux Pumps and Different Genetic Contexts of tet(X4) Contribute to High Tigecycline Resistance in Escherichia fergusonii from Pigs.
The study identifies the tet(X4) gene and other tetracycline resistance genes, along with efflux pumps, as contributors to high tigecycline resistance in E. fergusonii from pigs.
A point mutation in recC associated with subclonal replacement of carbapenem-resistant Klebsiella pneumoniae ST11 in China.
The study identifies multiple AMR genes including blaLAP-2, dfrA-like, qnr-like, sul-like, and tet(A) in hypervirulent and multidrug-resistant Klebsiella pneumoniae ST11 subclones, highlighting their role in the epidemic spread of these strains.
Investigating Possible Interspecies Communication of Plasmids Associated with Transfer of Third-Generation Cephalosporin, Quinolone, and Colistin Resistance Between Simultaneously Isolated Escherichia Coli and Klebsiella Pneumoniae.
The study identified multiple AMR genes in E. coli and K. pneumoniae isolates, including bla CTX-M-14, qnrS1, mcr-1.1, and others, highlighting the role of plasmids in the transfer of resistance genes between species.
Virotyping and genetic antimicrobial susceptibility testing of porcine ETEC/STEC strains and associated plasmid types.
The study identified several AMR genes and mutations in porcine ETEC/STEC strains, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-106), polymyxin resistance genes (mcr-1.1, mcr-2.1, mcr-5.1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-IV, aac(3)-IVa, aph(3')-Ia, aadA1, aadA10, aadA12), florfenicol resistance gene (floR), tetracycline resistance genes (tet(A), tet(B)), quinolone resistance gene (qnrS1), and trimethoprim-sulfamethoxazole resistance genes (dfrA1, dfrA5, dfrA12, dfrA14, dfrA36).
Genomic Surveillance of Salmonella from the Comunitat Valenciana (Spain).
The study identified multiple antimicrobial resistance genes including mcr-1, tet(A), aadA2, dfrA12, sul1, sul3, and ant(3")-Ia, along with mutations in gyrA that confer resistance to various antibiotics in Salmonella isolates from the Comunitat Valenciana, Spain.
Prevalence and Persistence of Antibiotic Resistance Determinants in the Gut of Travelers Returning to the United Kingdom is Associated with Colonization by Pathogenic Escherichia coli.
The study identified various antibiotic resistance genes in the gut microbiota of travelers returning to the UK, highlighting the association with colonization by pathogenic E. coli. Key findings include the prevalence of genes conferring resistance to macrolides, tetracyclines, sulfonamides, and others.
Multidrug-resistant non-typhoidal Salmonella of public health significance recovered from migratory birds in Bangladesh.
The study identified multidrug-resistant non-typhoidal Salmonella in migratory birds in Bangladesh, highlighting the presence of various AMR genes such as blaCARB-2, floR, sul1, tet(G), dfrA1, and mutations in gyrA and parC associated with quinolone resistance.
Clinically relevant antibiotic resistance in Escherichia coli from black kites in southwestern Siberia: a genetic and phenotypic investigation.
The study identified multiple antibiotic resistance genes in E. coli isolates from black kites in Siberia, including mcr-1 for colistin resistance, qnrE1 for fluoroquinolone resistance, and others such as bla TEM-1B, tet(A), sul2, and aph(3')-Ib.
Escherichia ruysiae May Serve as a Reservoir of Antibiotic Resistance Genes across Multiple Settings and Regions.
Multidrug-resistant Campylobacter jejuni, Campylobacter coli and Campylobacter lari isolated from asymptomatic school-going children in Kibera slum, Kenya.
The study identified multidrug-resistant strains of Campylobacter jejuni, Campylobacter coli, and Campylobacter lari in asymptomatic schoolchildren in Kenya, with high resistance rates to tetracycline, ciprofloxacin, nalidixic acid, and erythromycin. The most prevalent tetracycline resistance genes were tet(A), tet(O), and tet(C).
A national study confirms that Escherichia coli from Australian commercial layer hens remain susceptible to critically important antimicrobials.
The study found that Escherichia coli from Australian commercial layer hens show low rates of antimicrobial resistance, with most isolates susceptible to all tested antimicrobials. Resistance was observed for several antibiotics, including tetracycline, ampicillin, and ciprofloxacin, but no resistance to critical antimicrobials like colistin. Whole genome sequencing identified various AMR genes such as aadA1, dfrA1, strA, strB, sul1, sul2, tet(A), lnu(C), blaTEM-1B, and qnrS1.
Dominance of Escherichia coli sequence types ST73, ST95, ST127 and ST131 in Australian urine isolates: a genomic analysis of antimicrobial resistance and virulence linked to F plasmids.
The study identified various antimicrobial resistance genes in E. coli isolates from Australian urine samples, including blaCTX-M-15, blaCTX-M-14, blaTEM-28, sul1, sul2, sul3, dfrA17, dfrA5, dfrA1, dfrB4, tetA, tetB, mphA, cmlA1, cmlA5, catB3, sat2, qnrD1, fosA7, aac(3)-IId, aac(3)-IIe, aph(3')-IIa, aph(6)-Id, ant(3'')-IIa, intI1, and intI2. These genes were associated with resistance to various antibiotics such as beta-lactams, sulfonamides, trimethoprim, tetracycline, macrolides, chloramphenicol, streptothricin, quinolones, fosfomycin, and aminoglycosides.
Chromosome-Borne CTX-M-65 Extended-Spectrum β-Lactamase-Producing Salmonella enterica Serovar Infantis, Taiwan.
Case of Extensively Drug-Resistant Shigella sonnei Infection, United States
The study reports a case of extensively drug-resistant Shigella sonnei infection in an immunocompromised patient, highlighting the challenge of identifying XDR strains using traditional microbiological methods and emphasizing the need for whole-genome sequencing for accurate diagnosis. The isolate exhibited resistance to all first-line antimicrobials, including ciprofloxacin, azithromycin, and ceftriaxone, and carried several AMR genes such as blaCTX-M-27, qnrB19, mph(A), sul1, sul2, dfrA1, dfrA17, and tet(A).
Incidence and Genomic Background of Antibiotic Resistance in Food-Borne and Clinical Isolates of Salmonella enterica Serovar Derby from Spain.
The study identified several AMR genes, including aadA2, sul1, tet(A), tet(B), tet(C), blaTEM-1, and fosA7.3, in Salmonella enterica serovar Derby isolates from Spain. These genes were associated with resistance to streptomycin, sulfonamides, tetracycline, ampicillin, and fosfomycin. Additionally, a point mutation in the gyrA gene was linked to nalidixic acid resistance.
Clinical and Genomic Characterization of Carbapenem-Resistant Klebsiella pneumoniae with Concurrent Production of NDM and OXA-48-like Carbapenemases in Southern California, 2016-2022.
The study identified multiple carbapenemase genes, including bla NDM-1, bla NDM-5, bla OXA-232, and bla OXA-181, along with other AMR genes such as bla CTX-M-15, armA, tet(A), and tet(D), in carbapenem-resistant Klebsiella pneumoniae isolates from Southern California.
Genomic Characterization of Fecal Escherichia coli Isolates with Reduced Susceptibility to Beta-Lactam Antimicrobials from Wild Hogs and Coyotes.
The study identified beta-lactamase genes (blaCMY-2, blaCTX-M-55, blaCTX-M-27), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aac(3)-IId, aadA5, ant(3")-Ia, aph(3')-Ia, aph(3")-lb, aph(6)-ld), sulfonamide resistance genes (sul1, sul2, sul3), amphenicol resistance gene (floR), trimethoprim resistance genes (dfrA1, dfrA17), and MLS resistance genes (Inu(F), erm(B), mph(A)) in E. coli isolates from coyotes and wild hogs. Additionally, chromosomal mutations in ampC, gyrA, parC, and parE were found to confer resistance to beta-lactam and quinolone antibiotics.
The impact of applying various de novo assembly and correction tools on the identification of genome characterization, drug resistance, and virulence factors of clinical isolates using ONT sequencing.
The study evaluates the impact of various de novo assembly and read correction tools on the identification of antimicrobial resistance (AMR) genes, plasmids, and virulence factors in clinical Escherichia coli isolates using Oxford Nanopore sequencing. It highlights the effectiveness of Flye and Canu in detecting AMR genes and the importance of read correction tools like Medaka and Racon in improving assembly quality and AMR gene detection.
Genomic Analysis of an Escherichia coli Sequence Type 167 Isolate Harboring a Multidrug-Resistant Conjugative Plasmid, Suggesting the Potential Transmission of the Type Strains from Animals to Humans.
The study identifies multiple AMR genes in the E. coli ST167 isolate ECO3183, including bla_NDM-5, aac(6')-Ib-cr, aph(3')-Ia, aph(3")-Ib, aac(3)-IId, sul1, sul2, dfrA27, tet(A), floR, mph(A), and arr-3, which contribute to its multidrug-resistant phenotype. Additionally, a chromosomal gyrA mutation (p.S83L) was associated with fluoroquinolone resistance.
Genomic and functional portrait of multidrug-resistant, hydrogen sulfide (H(2)S)-producing variants of Escherichia coli.
The study identified multidrug-resistant, hydrogen sulfide-producing variants of Escherichia coli from Bangladesh, highlighting the presence of various AMR genes such as bla TEM1B, bla CTX-M-55, bla CTX-M-65, bla CTX-M-123, aadA1, aadA2, aph (3')-Ia, aph (3'')-Ib, aph (6)-Id, tet(A), tet(M), sul3, sul2, dfrA12, mph(A), floR, cmlA1, qacL, and qnrS1.
Genomic traits of multidrug resistant enterotoxigenic Escherichia coli isolates from diarrheic pigs.
The study identified 53 resistance genes and 13 categories of 195 virulence factors in multidrug-resistant ETEC isolates from diarrheic pigs, including tet(A), floR, aph(3')-Ia, aadA2, bleO, sul3, dfrA12, QnrS1, and tet(X4).
Poultry production as the main reservoir of ciprofloxacin- and tigecycline-resistant extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198.2-2 causing human infections in China.
The study identifies several AMR genes and mutations in Salmonella enterica serovar Kentucky ST198.2-2, including blaCTX-M-14b, blaCTX-M-55, blaTEM-1B, aadA7, aph(3')-Ia, aac(3)-IId, rmtB, tet(A), sul1, dfrA14, floR, lnu(F), mph(A), arr-2, and fosA3, which confer resistance to various antibiotics. Mutations in gyrA and parC also contribute to fluoroquinolone resistance.
Prevalence and molecular characterization of cefotaxime-resistant Salmonella strains recovered from retail meat samples in Shenzhen, China, during 2014-2017.
The study identified several beta-lactamase genes, including bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, bla CTX-M-130, bla CTX-M-27, and bla CMY-2, as well as other resistance genes such as qnrS1, qnrB6, mph(A), oqxAB, mcr-1.1, tet(A), tet(B), sul1, sul2, sul3, aac(6')-Ib, aph(3")-Ib, floR, drfA14, drfA1, and Inu(F), which contribute to cefotaxime resistance in Salmonella strains isolated from retail meat samples in Shenzhen, China.
Genetic Diversity and Antimicrobial Resistance of Extraintestinal E. coli Populations Pre- and Post-Antimicrobial Therapy on Broilers Affected by Colisepticemia.
The study identified several AMR genes and mutations in extraintestinal E. coli populations from broilers treated with enrofloxacin. Key findings include the presence of qnrB19 and qnrS1 genes, which confer fluoroquinolone resistance, and mutations in gyrA, parC, and parE genes associated with fluoroquinolone resistance. Additionally, multiple other AMR genes were detected, indicating multidrug resistance.
Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Causing Nosocomial Meningitis in the Neurological Intensive Care Unit.
The study identified various AMR genes in 37 A. baumannii strains causing nosocomial meningitis, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, macrolide resistance genes, phenicol resistance genes, sulfonamide resistance genes, rifamycin resistance genes, and antiseptic resistance genes.
Plasmids conferring resistance to extended-spectrum beta-lactamases including a rare IncN+IncR multireplicon carrying bla(CTX-M-1) in Escherichia coli recovered from migrating barnacle geese ( Branta leucopsis).
The study identified several AMR genes in ESBL/AmpC-producing E. coli isolates from barnacle geese, including bla(CTX-M-1), bla(CTX-M-15), bla(CMY-2), aadA2b, lnu(F), and qnrS1, which confer resistance to various beta-lactams, aminoglycosides, lincomycin, and quinolones.
Unraveling virulence determinants in extended-spectrum beta-lactamase-producing Escherichia coli from East Africa using whole-genome sequencing.
The study identified several AMR genes in ESBL-producing E. coli isolates from Uganda and Tanzania, including blaCTX-M-15, blaCTX-M-27, blaTEM-1B, mdfA, tet(B), sul1, tet(A), and sul2, which confer resistance to beta-lactams, fluoroquinolones, third-generation cephalosporins, chloramphenicol, tetracyclines, and sulfonamides.
First Isolation and Identification of Aeromonas veronii in a Captive Giant Panda (Ailuropoda melanoleuca).
The study identifies 31 antibiotic resistance genes in Aeromonas veronii strain VGP, including aac, tetA-02, tnpA-05, aacC, and aadA2-02, which confer resistance to various antibiotics such as aminoglycosides, tetracycline, and others. The strain was found to be resistant to six antibiotics: penicillin, ampicillin, oxacillin, amoxicillin, imipenem, and vancomycin.
Co-integrate Col3m bla (NDM-1)-harboring plasmids in clinical Providencia rettgeri isolates from Argentina.
The study characterizes bla NDM-1-harboring plasmids in clinical Providencia rettgeri isolates from Argentina, highlighting the presence of various resistance genes such as bla NDM-1, aac(6')-Ib-cr5, aph(3')-Ia, aph(3')-VI, bla PER-2, qnr D1, sul1, sul2, arr3, catB3, floR, mph(E), msr(E), and tet(A).
The origin and evolution of IncF33 plasmids based on large-scale data sets.
The study identifies several clinically important antibiotic resistance genes carried by IncF33 plasmids, including bla CTX-M-55, bla CTX-M-65, fosA3, rmtB, aph(3'')-Ib, aph(6)-Id, aph(3')-IIa, floR, oqxAB, tet(A), and sul2. These genes contribute to multidrug resistance in Enterobacterales, particularly in Escherichia coli, Salmonella, and Klebsiella pneumoniae.
Polyclonal Multidrug ESBL-Producing Klebsiella pneumoniae and Emergence of Susceptible Hypervirulent Klebsiella pneumoniae ST23 Isolates in Mozambique.
The study identified multiple AMR genes in Klebsiella isolates, including bla CTX-M-15, bla TEM-1, bla SHV, and bla OXA-1, which confer resistance to beta-lactams. Other genes like aac(3)-IIa, aac(6')-Ib-cr, qnrB1, qnrB6, catA1, catA2, catB3, dfrA5, dfrA7, dfrA12, dfrA14, dfrA27, sul1, sul2, mph(A), tet(A), tet(D), fosA, ARR-3, and oqxAB were also found, contributing to resistance against aminoglycosides, quinolones, chloramphenicol, trimethoprim, sulfamethoxazole, macrolides, tetracycline, fosfomycin, rifampicin, and quinolones respectively. Mutations in ompK36, ompK37, and acrR were associated with resistance to cephalosporins and fluoroquinolones, while mutations in RamR were linked to tigecycline resistance.
Molecular characterization of highly prevalent Escherichia coli and Escherichia marmotae resistant to extended-spectrum cephalosporins in European starlings (Sturnus vulgaris) in Tunisia.
The study identified several extended-spectrum beta-lactamase (ESBL) and AmpC resistance genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, bla CMY-2, and bla CMY-62, in Escherichia coli and Escherichia marmotae isolates from European starlings in Tunisia. Additionally, aminoglycoside resistance genes such as aph(6)-Id and aph(3″)-Ib, along with fosA3, sul1, sul2, sul3, drfA1, drfA17, tet(A), and qnrS1 were also characterized.
Genomic Analysis of Multidrug-Resistant Escherichia coli Strains Isolated in Tamaulipas, Mexico.
The study identified multiple antimicrobial resistance genes (ARGs) in multidrug-resistant E. coli strains isolated from human clinical, animal, and environmental sources in Tamaulipas, Mexico. These genes include beta-lactamases (bla CTX-M-15, bla OXA-1, bla TEM-1B, bla CMY-2), aminoglycoside resistance genes (aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aadA5, aac3-IIa), sulfonamide resistance genes (sul2, sul3), phenicol resistance gene (catB3), tetracycline resistance genes (tet(A), tet(B)), quaternary ammonium resistance genes (qacE, qacL), macrolide resistance genes (mdfA, mphA), and quinolone resistance gene (qnrB).
Prioritization of Critical Factors for Surveillance of the Dissemination of Antibiotic Resistance in Pseudomonas aeruginosa: A Systematic Review.
The study identifies 25 critical mobile antibiotic resistance genes (ARGs) in Pseudomonas aeruginosa, including genes such as sul1, qacEΔ1, aac(6′)-Ib, bla VIM-1, and others, which are associated with various antibiotic classes and are linked to mobile genetic elements (MGEs).
Synergistic effects of polymyxin and vancomycin combinations on carbapenem- and polymyxin-resistant Klebsiella pneumoniae and their molecular characteristics.
Study of heavy metal resistance genes in Escherichia coli isolates from a marine ecosystem with a history of environmental pollution (arsenic, cadmium, copper, and mercury).
The study identified several heavy metal resistance genes (HMRGs) in Escherichia coli isolates from a marine ecosystem with a history of environmental pollution, highlighting the prevalence of these genes and their potential interactions with antibiotic resistance genes.
Resistome and virulome of high-risk pandemic clones of multidrug-resistant extra-intestinal pathogenic Escherichia coli (ExPEC) isolated from tertiary healthcare settings in Uganda.
The study identified various AMR genes in multidrug-resistant E. coli isolates, including blaCTX-M-15, blaTEM-1B, blaOXA-1, and others, which confer resistance to beta-lactams, aminoglycosides, sulfonamides, tetracyclines, macrolides, and quinolones. Additionally, chromosomal mutations in gyrA and parC were found to contribute to fluoroquinolone resistance.
Genomic Diversity, Antimicrobial Resistance, Plasmidome, and Virulence Profiles of Salmonella Isolated from Small Specialty Crop Farms Revealed by Whole-Genome Sequencing.
CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic Escherichia coli.
The study identified several AMR genes carried on IncF plasmids in MDR ExPEC strains, including bla TEM-1, aac(3)-IId, tet(A), aph(6)-Id, aph(3')-Ib, mphA, sul1, sul2, aadA5, dfrA17, strAB, qacEdelta1, bla CTX-M-14, bla CTX-M-15, catB3, bla OXA-1, bla CTX-M-27, and aac(6')-Ib-cr5. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, sulfonamides, and chloramphenicol.
Genomic characterization of tigecycline-resistant Escherichia coli and Klebsiella pneumoniae isolates from hospital sewage.
The study identifies tet(X4) and tmexCD1-toprJ1 as key genes contributing to tigecycline resistance in E. coli and K. pneumoniae isolates from hospital sewage, highlighting the role of plasmid-mediated resistance and efflux pump overexpression.
Occurrence and temporal distribution of extended-spectrum β-lactamase-producing Escherichia coli in clams from the Central Adriatic, Italy.
The study identified several β-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV12, bla CMY-2, bla TEM-1B, bla TEM-106, and bla TEM-126, which confer resistance to various β-lactam antibiotics. Other resistance genes such as aac(6′)-Ib-cr, qnrS1, tet(A), tet(B), tet(M), aadA5, aadA2b, sul1, sul2, sul3, dfrA17, dfrA5, dfrA14, dfrA12, mph(A), cmlA1, catA2, aac(3)-IIa, aac(3)-IId, and lnu(F) were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates from clams in the Central Adriatic.
Complete genome sequence and comparative analysis of a Vibrio vulnificus strain isolated from a clinical patient.
Prevalence and genomic characterization of Salmonella isolates from commercial chicken eggs retailed in traditional markets in Ghana.
The study identified several AMR genes and mutations in Salmonella isolates from chicken eggs in Ghana, including aadA1, aph(3")-Ib, aph(6)-Id, catA1, dfrA1, dfrA14, fosA7.2, qnrB19, sul1, sul2, and tet(A), as well as mutations in gyrA (D87N) and gyrA (S83Y).
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
The study identified multiple AMR genes and mutations in ESBL-producing E. coli and K. pneumoniae isolates from bulk tank milk, highlighting the presence of multidrug-resistant strains with resistance to beta-lactams, fluoroquinolones, aminoglycosides, and tetracyclines.
Antimicrobial resistance and genomic characteristics of Salmonella from broilers in Shandong Province.
The study identified multiple antimicrobial resistance genes in Salmonella isolates from broilers in Shandong Province, including tet(A), floR, cmlE, blaTEM, aph(4)-Ia, qnrS1, and mcr-1, highlighting the prevalence of multidrug-resistant strains.
Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance.
The study identified multiple antimicrobial resistance genes and mutations in Shigella isolates from Lebanon, including bla CTX-M-15 and bla CTX-M-3 for extended-spectrum beta-lactamase resistance, and gyrA mutations for quinolone resistance.
Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients.
The study characterizes various AMR genes, including bla CTX-M-15, bla TEM-1B, bla OXA-1, qnrB1, qnrS1, aph(6)-Id, aph(3”)-Ib, aac(3)-IIa, ant(3”)-Ia, dfrA14, dfrA1, aac(6’)-Ib-cr, tet(A), tet(D), sul2, sul1, fosA6, fosA_5, fosA_3, bla CTX-M-1, bla CTX-M-14, bla CTX-M-14b, bla CTX-M-8, bla CMY-2, bla TEM-190, aac(3)-IVa, aph(4)-Ia, and catB3_2, in ESBL-producing Enterobacterales isolates from long-term colonized patients.
Characterization of Riemerella anatipestifer Strains Isolated from Various Poultry Species in Poland.
The study identified several AMR genes in R. anatipestifer isolates, including aminoglycoside resistance genes (aph(3′)-VII, aac(3′)-IV, aadA, strA/strB), tetracycline resistance genes (tet(A), tet(B), tet(X)), erythromycin resistance gene (ermF), chloramphenicol resistance gene (cmlA), beta-lactam resistance gene (bla TEM), and sulfonamide resistance gene (sulI).
Assessing the Effect of Oxytetracycline on the Selection of Resistant Escherichia coli in Treated and Untreated Broiler Chickens.
The study identified tet(A) and tet(C) genes as the most prevalent tetracycline resistance genes in E. coli isolates from treated and untreated broiler chickens, indicating that active efflux pumps are the primary resistance mechanism.
Tigecycline Sensitivity Reduction in Escherichia coli Due to Widely Distributed tet(A) Variants.
The study identifies five distinct tet(A) variants that reduce tigecycline sensitivity in E. coli, with the V55M mutation being validated as a key contributor to tigecycline resistance.
Genomic characterization of Salmonella isolated from retail chicken and humans with diarrhea in Qingdao, China.
The study identified 79 antimicrobial resistance genes (ARGs) in Salmonella isolates from retail chicken and humans with diarrhea in Qingdao, China, including aac(6')-Iaa, bla TEM-1B, tet(A), aph(6)-Id, aph(3")-Ib, sul2, floR, qnrS1, bla NDM-1, mcr-1.1, and mcr-9.1. These genes conferred resistance to various antibiotics such as aminoglycosides, beta-lactams, tetracyclines, sulfonamides, chloramphenicol, fluoroquinolones, carbapenems, and colistin.
Determination of antibiotic resistance patterns and genotypes of Escherichia coli isolated from wild birds.
The study identified several AMR genes in E. coli isolates from wild birds, including tet(A), tet(B), strA/strB, aphA1, sul1, sul2, and sul3, which confer resistance to tetracycline, streptomycin, kanamycin, and sulfonamides.
Metagenomic identification of pathogens and antimicrobial-resistant genes in bacterial positive blood cultures by nanopore sequencing.
The study identified various antimicrobial resistance (AMR) genes in bacterial positive blood cultures using nanopore sequencing, demonstrating the effectiveness of this method in detecting resistance mechanisms and pathogens quickly.
Mechanism for transmission and pathogenesis of carbapenem-resistant Enterobacterales harboring the carbapenemase IMP and clinical countermeasures.
The study identifies blaIMP-4 and blaIMP-26 as carbapenemase genes responsible for carbapenem resistance in Enterobacterales. Additionally, various other AMR genes such as aac(6')-lb3, armAC, aph(3'')-lb, aph(6)-ld, aadA5, aac(6')-llc, aac(3)-IId, dfrA19, dfrA1, sul1, tet(D), tet(A), qnrS1, qnrB4, msr(E), mph(E), ere(A), mph(A), mcr-9, and ARR-3 were characterized for their roles in resistance to different antibiotics.
Genotypic Characterization of Uropathogenic Escherichia coli from Companion Animals: Predominance of ST372 in Dogs and Human-Related ST73 in Cats.
The study identified several AMR genes and mutations in uropathogenic E. coli isolates from companion animals, including blaTEM-1B, sul2, tet(A), qnrS1, aac(6')-Ib-c, qnrS2, qnrB19, qnrB4, CTX-M-15, CTX-M-27, CMY-2, DHA-1, blaEC, blaEC-6, and mcr-4.6. Mutations in gyrA (S83L, D87N) and parC (S80I) were also found to confer fluoroquinolone resistance.
Predicting Salmonella MIC and Deciphering Genomic Determinants of Antibiotic Resistance and Susceptibility.
The study presents a novel 'Genome Feature Extractor Pipeline' that uses machine learning and deep learning to predict Salmonella MIC values based on 20-mer counts from WGS data. The pipeline identifies key genomic features associated with antibiotic resistance, including known resistance genes such as beta-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes, tetracycline efflux pumps, and sulfonamide resistance genes.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Genomic Characterization of a Plasmid-Free and Highly Drug-Resistant Salmonella enterica Serovar Indiana Isolate in China.
The study identifies 54 AMR genes and three AMR gene cassettes in the plasmid-free, highly drug-resistant Salmonella enterica serovar Indiana isolate S1467, contributing to resistance against multiple antimicrobial classes.
Whole-Genome Sequencing of an Escherichia coli ST69 Strain Harboring bla(CTX-M-27) on a Hybrid Plasmid.
The study identifies a multidrug-resistant E. coli ST69 strain carrying the bla(CTX-M-27) gene on a hybrid plasmid, along with various other antibiotic resistance genes such as aminoglycoside, macrolide, sulfonamide, tetracycline, and trimethoprim resistance genes.
ST218 Klebsiella pneumoniae became a high-risk clone for multidrug resistance and hypervirulence.
The study identifies bla NDM-1, qnrS1, and tet(A) as key resistance genes in ST218 Klebsiella pneumoniae, highlighting its multidrug resistance and hypervirulence.
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
The study identified various antimicrobial resistance genes and mutations in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain, highlighting the presence of multidrug-resistant strains and the role of plasmids in the dissemination of resistance mechanisms.
Overview of Ecology and Aspects of Antibiotic Resistance in Campylobacter spp. Isolated from Free-Grazing Chicken Tissues in Rural Households.
The study identified several AMR genes and mutations in Campylobacter spp. isolated from free-grazing chickens, including blaOxA-61, tet(O), tet(A), cmeA, cmeB, cmeC, and a Thr-86-Ile mutation in gyrA, contributing to multidrug resistance.
Antibiotic resistance and virulence genes profile of Non typhodial Salmonella species isolated from poultry enteritis in India.
The study identified several antibiotic resistance genes including blaTEM, blaSHV, blaCTX-M, tet(A), tet(B), tet(C), sul1, sul2, and sul3 in multidrug-resistant Salmonella isolates from poultry enteritis in India.
Whole-genome sequencing-based antimicrobial resistance and shedding dynamics of Escherichia coli isolated from calves before and after antimicrobial group treatments.
The study identified several AMR genes and mutations in E. coli isolates from calves, including tetracycline resistance genes (Tet(A), Tet(B), Tet(C), Tet(M)), β-lactamases (TEM-1, TEM-35, OXA-1), florfenicol resistance gene FloR, and macrolide phosphotransferase Mph(B). Mutations in GyrA (D87N, D87Y, S83L) and ParC (S80I) were also associated with quinolone resistance.
Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity.
The study identifies multiple antibiotic resistance genes in E. coli WG5D, including multidrug efflux pumps and genes conferring resistance to various antibiotics such as fluoroquinolones, cephalosporins, and glycopeptides.
Genetic Characteristics of Extended-Spectrum Beta-Lactamase-Producing Salmonella Isolated from Retail Meats in South Korea.
The study identified blaCTX-M-15, tet(A), and aac(6')-Iaa as the primary AMR genes in ESBL-Sal strains isolated from retail meats in South Korea, contributing to resistance against beta-lactams, tetracycline, and aminoglycosides.
Genomic analysis of Salmonella isolated from canal water in Bangkok, Thailand.
The study identified 35 AMR genes and 30 chromosomal-mediated gene mutations in Salmonella strains from Bangkok canal water, highlighting the presence of multidrug-resistant strains with resistance to various antimicrobial classes.
Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease.
The study characterizes three ciprofloxacin-resistant and extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198 strains from a single patient with inflammatory bowel disease, highlighting their multidrug-resistant profile and potential epidemiological links to strains from chicken meat.
Molecular mechanisms of tigecycline-resistance among Enterobacterales.
The paper reviews the molecular mechanisms of tigecycline resistance in Enterobacterales, highlighting the roles of efflux pumps, tet genes, and other resistance mechanisms. It identifies several tigecycline resistance genes, including tet(X), tet(X1), tet(X2), tet(X3), tet(X4), tet(M), tet(A), tet(B), tet(Y), and others, along with their associated resistance profiles.
Comparison of IncK-bla(CMY-2) Plasmids in Extended-Spectrum Cephalosporin-Resistant Escherichia coli Isolated from Poultry and Humans in Denmark, Finland, and Germany.
The study characterizes IncK-bla(CMY-2) plasmids in extended-spectrum cephalosporin-resistant E. coli isolates from poultry and humans in Denmark, Finland, and Germany, identifying multiple resistance genes including bla(CMY-2), aadA1, aac(3)-Vla, aph(3")-Ib, aph(6)-Id, aac(3)-IId, aadA5, aph(3′)-Ia, sul1, sul2, tet(A), tet(B), and bla TEM-1B.
Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance.
The study identifies three mechanisms (tandem amplification, increased plasmid copy number, and transposition of resistance genes) that generate gene copy number variation and transient antibiotic heteroresistance in Klebsiella pneumoniae and Escherichia coli.
Generation and maintenance of the circularized multimeric IS26-associated translocatable unit encoding multidrug resistance.
The study identifies the amplification of the P2 region containing multiple AMR genes, including bla CTX-M-14, tet(A), drfA, and sul1, in Klebsiella pneumoniae isolates under antimicrobial selection pressure.
Chlorogenic acid attenuates tet (X)-mediated doxycycline resistance of Riemerella anatipestifer.
The study identifies tet(X), tet(A), and tet(O) as key tetracycline resistance genes in Riemerella anatipestifer, demonstrating their role in doxycycline resistance. Chlorogenic acid was found to reduce the expression of these genes and enhance susceptibility to doxycycline.
Cryptic environmental conjugative plasmid recruits a novel hybrid transposon resulting in a new plasmid with higher dispersion potential.
The study identifies a novel hybrid transposon Tn7714 carrying multiple antibiotic resistance genes (ARGs) that was transferred from an IncF plasmid to a cryptic IncX plasmid, resulting in a new multidrug-resistant conjugative plasmid with significantly higher conjugation efficiency.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
The study identifies multiple AMR genes and mutations in multidrug-resistant E. coli strains causing infections in dogs and cats, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla CMY-2, bla CMY-148, aac(6')-Ib-cr, qnrS1, qnrB6, aadA2, aadA5, aadA16, ant(3′′)-Ia, aph(3′)-Ia, aph(3′′)-Ib, aph(6)-Id, rmtB, floR, cmlA, catA, sul1, sul2, sul3, dfrA12, dfrA14, dfr17, dfrA27, tet(A), tet(B), tet(M), mph(A), erm(B), lnu(F), and arr-3, as well as the gyrA:p.S83L mutation.
Synanthropic rodents and shrews are reservoirs of zoonotic bacterial pathogens and act as sentinels for antimicrobial resistance spillover in the environment: A study from Puducherry, India.
The study identified various AMR genes in bacterial isolates from synanthropic rodents and shrews, including mecA, mecC, blaTEM, blaSHV, blaCTX-M, tet, sul3, sul4, and qnrA, indicating their role as reservoirs of AMR pathogens.
Detection of Salmonella Pathogenicity Islands and Antimicrobial-Resistant Genes in Salmonella enterica Serovars Enteritidis and Typhimurium Isolated from Broiler Chickens.
The study identified several antimicrobial-resistant genes in Salmonella enterica serovars Enteritidis and Typhimurium isolated from broiler chickens, including tet(K), tet(O), tet(A), mcr-1, mcr-4, strA, strB, aadA, aadE, sulI, ampC, TEM, CTX-M, and OXA. These genes conferred resistance to tetracycline, colistin, aminoglycosides, sulfonamides, and beta-lactam antibiotics.
Occurrence, molecular characterization, and antimicrobial susceptibility of sorbitol non-fermenting Escherichia coli in lake water, fish and humans in central Oromia, Ethiopia.
The study identified multiple antimicrobial resistance genes in sorbitol non-fermenting E. coli strains, including blaTEM-1B, tet(A), dfrA1, dfrA5, sul1, fos7, catA1, qnrS1, gyrA, and blaCTX-M15, which conferred resistance to various antibiotics such as ampicillin, tetracycline, trimethoprim, sulfamethoxazole, fosfomycin, chloramphenicol, ciprofloxacin, nalidixic acid, and extended-spectrum beta-lactams.
Occurrence and genomic characterization of antimicrobial-resistant and potential pathogenic Escherichia coli from Italian artisanal food productions of animal origin.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia coli isolates from Italian artisanal food products, including beta-lactamases, aminoglycoside-modifying enzymes, trimethoprim resistance genes, macrolide resistance genes, quinolone resistance proteins, sulfonamide resistance proteins, and tetracycline resistance genes. These genes were primarily carried on plasmids and contributed to multidrug resistance.
Genomic characterisation of Escherichia coli isolated from poultry at retail through Sink Surveillance in Dhaka, Bangladesh reveals high levels of multi-drug resistance.
The study identified multiple AMR genes in E. coli isolates from poultry in Bangladesh, including genes conferring resistance to various antibiotics such as tetracycline, ciprofloxacin, azithromycin, colistin, and others. High levels of multidrug resistance were observed, with specific genes like mcr1.1, bla CTX-M-65, and tet(A) playing significant roles.
Four novel Acinetobacter lwoffii strains isolated from the milk of cows in China with subclinical mastitis.
Four Acinetobacter lwoffii strains were isolated from the milk of cows with subclinical mastitis in China. These strains exhibited multidrug resistance and carried 17 resistance genes, including beta-lactamase, aminoglycoside-modifying, fluoroquinolone, tetracycline, sulfonamide, and chloramphenicol resistance genes.
The IncC and IncX1 resistance plasmids present in multi-drug resistant Escherichia coli strains isolated from poultry manure in Poland.
The study identifies three resistance plasmids (pECmdr13.2, pECmdr13.3, pECmdr14.1) in multi-drug resistant E. coli strains from poultry manure in Poland, each carrying various AMR genes including tetracycline, aminoglycoside, beta-lactam, sulfonamide, fluoroquinolone, and phenicol resistance genes.
A newly identified IncY plasmid from multi-drug-resistant Escherichia coli isolated from dairy cattle feces in Poland.
The study identifies two IncY plasmids from multi-drug-resistant E. coli isolated from dairy cattle feces in Poland, carrying resistance genes against beta-lactams, aminoglycosides, tetracyclines, trimethoprim/sulfamethoxazole, and fluoroquinolones.
Starvation resilience of Klebsiella species in oral and nasal microbiomes
The study identifies the presence of beta-lactamase genes in Klebsiella pneumoniae isolates from healthy human oral and nasal cavities, highlighting their multidrug resistance properties.
Mobile genetic elements define the non-random structure of the Salmonella enterica serovar Typhi pangenome.
The study identifies multiple AMR genes, including blaTEM-1B, qnrS1, sul2, tet(A), aph(3'')-Ib, aph(6)-Id, dfrA14, blaCTX-M-15, blaCTX-M-88, catA1, qacE, sul1, and tet(B), which are associated with multidrug-resistant and extensively drug-resistant Salmonella enterica serovar Typhi strains.
Host species shapes genotype, antimicrobial resistance, and virulence profiles of enterotoxigenic Escherichia coli (ETEC) from livestock in the United States.
The study identifies distinct antimicrobial resistance (AMR) gene profiles in bovine and swine enterotoxigenic Escherichia coli (ETEC) isolates, highlighting differences in the prevalence of specific AMR genes and plasmid replicons between the two host species.
Tracing the origin of NDM-1-producing and extensively drug-resistant Pseudomonas aeruginosa ST357 in the Netherlands.
The study identifies the NDM-1-producing Pseudomonas aeruginosa ST357 as an extensively drug-resistant strain with a unique resistome, highlighting the importance of tracking the origin of such isolates through genomic epidemiology.
Carriage Rate of Enterobacterales Resistant to Extended-Spectrum Cephalosporins in the Tunisian Population.
The study identified bla CTX-M-15 and bla DHA-1 as the primary genes conferring resistance to extended-spectrum cephalosporins in Enterobacterales isolated from healthy Tunisian individuals. Additional resistance mechanisms included aminoglycoside, sulfonamide, tetracycline, and quinolone resistance genes.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
The ISVsa3-ORF2-abh-tet(X4) circular intermediate-mediated transmission of tigecycline resistance in Escherichia coli isolates from duck farms.
The study identifies the tet(X4) gene in E. coli isolates from duck farms, demonstrating its presence in a circular intermediate and its ability to transfer via conjugation, highlighting the potential for widespread tigecycline resistance.
Antibiotic Resistance Genes and Plasmid Characteristics in Enterobacteriaceae Isolated from Fresh Produce
The study identified several antibiotic resistance genes on plasmids and chromosomes of Enterobacteriaceae strains isolated from fresh produce, highlighting the diversity of resistance mechanisms and the potential for horizontal gene transfer.
Geneticand phenotypic characterization of a novel ST45-K43 carbapenem-resistant Klebsiella pneumoniae strain causing bloodstream infection: a potential clinical threat.
The study identifies a novel ST45-K43 carbapenem-resistant Klebsiella pneumoniae strain, 18SHX166, carrying multiple antimicrobial resistance genes including bla KPC-2, oqxA, oqxB, fosA7, bla SHV26, aph(3′)-Ia, bleO, tet(A), dfrA14, and bla TEM1B. The strain exhibits multidrug resistance and high transmissibility.
Genomic Characteristics of a Carbapenem-Resistant Klebsiella pneumoniae Co-Carrying bla (NDM-5) and bla (KPC-2) Capsular Type KL25 Recovered from a County Level Hospital in China.
The study reports the genomic characteristics of a multidrug-resistant ST11 Klebsiella pneumoniae isolate SM117 with capsular serotype KL25, co-carrying bla NDM-5, two copies of bla KPC-2, and multiple plasmid-borne virulence genes. The isolate shows resistance to all antibiotics except polymyxin.
Antibiotic resistance, virulence genes, and phylogenetic groups of bacteria isolated from wild passerine birds in Iran.
The study identified tetracycline resistance genes (tet(A), tet(B), tet(M), tet(L)) and the blaTEM gene associated with ampicillin resistance in bacteria isolated from wild passerine birds in Iran.
Genomic Characterization of Extended-Spectrum β-Lactamase-Producing and Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from Stools of Primary Healthcare Patients in Ethiopia.
The study identified multiple antimicrobial resistance genes in E. coli isolates, including bla CTX-M-15, bla TEM-1B, tet(A), qnrS1, and others, highlighting the prevalence of multidrug resistance in the region.
Genome-Based Analysis of Genetic Diversity, Antimicrobial Susceptibility, and Virulence Gene Distribution in Salmonella Pullorum Isolates from Poultry in China.
The study identified several AMR genes and mutations in Salmonella Pullorum isolates from China, including aac(6')-Iaa, aadA5, blaTEM1β, sul2, tet(A), and qacE, as well as gyrA mutations (S83F, S84F, D87N), which are associated with resistance to streptomycin, ampicillin, ciprofloxacin, sulfamethoxazole, tetracycline, and disinfectants.
Genomic Insights into Vietnamese Extended-Spectrum β-Lactamase-9-Producing Extensively Drug-Resistant Pseudomonas aeruginosa Isolates Belonging to the High-Risk Clone ST357 Obtained from Bulgarian Intensive Care Unit Patients.
The study identified multiple AMR genes, including blaVEB-9, blaPDC-3, blaOXA-10, blaOXA-50, and others, in two extensively drug-resistant Pseudomonas aeruginosa isolates from Bulgaria. These genes conferred resistance to various antibiotics, including β-lactams, aminoglycosides, and fluoroquinolones.
Comprehensive Genomic Analysis of Uropathogenic E. coli: Virulence Factors, Antimicrobial Resistance, and Mobile Genetic Elements.
The study identified numerous antimicrobial resistance genes and mutations in uropathogenic E. coli isolates, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and quinolone resistance genes. Mutations in gyrA, parC, parE, and marR were associated with fluoroquinolone resistance, while mutations in PmrB, CyaA, GlpT, PtsI, and UhpT were linked to fosfomycin resistance.
First report of carbapenems encoding multidrug-resistant gram-negative bacteria from a pediatric hospital in Gaza Strip, Palestine.
The study identified multiple carbapenem resistance genes, including bla KPC-2, bla PDC-36/12, and bla POM-1, in multidrug-resistant Gram-negative bacteria isolated from a pediatric hospital in the Gaza Strip. These genes were found in various bacterial species such as Escherichia coli and Klebsiella pneumoniae.
Salmonella enterica serovars Takoradi, Tananarive and Uganda from foods in Tripura, their virulence & antimicrobial resistance.
The study identifies Salmonella enterica serovars Takoradi, Tananarive, and Uganda from food samples in Tripura, highlighting their resistance to tetracycline and reduced susceptibility to azithromycin.
Occurrence of Extended-spectrum β-lactamase (ESBL) and Carbapenemase-producing Escherichia coli isolated from Childhood Diarrhoea in Yaoundé, Cameroon.
The study identified several AMR genes, including bla CTX−M, bla TEM, bla OXA−48, tet(A), and tet(B), in ESBL-producing E. coli isolates from childhood diarrhoea in Yaoundé, Cameroon. These genes confer resistance to various antibiotics, highlighting the urgent need for improved surveillance and antimicrobial stewardship.
Metagenomic assemblies tend to break around antibiotic resistance genes.
The study evaluates the performance of various metagenomic assemblers in capturing antibiotic resistance genes (ARGs) and their genomic contexts, highlighting challenges in accurately reconstructing ARGs from short-read data.
Emergence of bla(OXA-181)-bearing tigecycline-resistant Klebsiella aerogenes in China.
The study reports the isolation of a tigecycline-resistant Klebsiella aerogenes strain carrying the blaOXA-181 gene on an IncX3 plasmid, along with the qnrS1 and tet(A) genes, indicating multidrug resistance.
Analyzing Antibiotic Resistance in Bacteria from Wastewater in Pakistan Using Whole-Genome Sequencing.
The study identifies several AMR genes and mutations in wastewater isolates from Pakistan, highlighting the presence of carbapenemases like blaNDM-5 and blaOXA-1, as well as quinolone resistance determinants such as gyrA and parC mutations. These findings emphasize the role of wastewater as a reservoir for clinically relevant AMR genes.
Determinants of Antibiotic Resistance and Virulence Factors in the Genome of Escherichia coli APEC 36 Strain Isolated from a Broiler Chicken with Generalized Colibacillosis.
The study identifies multiple antibiotic resistance genes in the E. coli APEC 36 strain, including beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and efflux pumps, indicating a high level of multidrug resistance.
Characterization of Extraintestinal Pathogenic Escherichia coli Strains Causing Canine Pneumonia in China: Antibiotic Resistance, Virulence Genes, and Sequence Typing.
Four multidrug-resistant strains of extraintestinal pathogenic Escherichia coli (ExPEC) were identified in puppies with acute pneumonia, carrying resistance genes such as TEM, CTX-M-55, mec, tet, AAC-IId, cmlA, dfrA, and sul. These strains were classified as ST131 or ST43 and showed resistance to cephalosporins, tetracyclines, and penicillins, but were susceptible to aminoglycosides, beta-lactamase inhibitors, carbapenems, chloramphenicols, and sulfonamides.
Virulence, multiple drug resistance, and biofilm-formation in Salmonella species isolated from layer, broiler, and dual-purpose indigenous chickens.
The study identified several antimicrobial resistance genes in Salmonella isolates from different chicken types, including ant (3"-la), tet (A), tet (B), sul1, and sul2, indicating multidrug resistance.
An ovine septic shock model of live bacterial infusion.
The study characterizes the AMR genes blaCTX-M-15, aac(6')-Ib, aph(3')-Ib, and tet(A) in the E. coli strain EC958, which shows resistance to multiple antibiotic classes including third-generation cephalosporins, aminoglycosides, and tetracyclines.
Genomic characterization of a clonal emergent Salmonella Minnesota lineage in Brazil reveals the presence of a novel megaplasmid of resistance and virulence.
The study identifies multidrug resistance genes such as bla CMY-2, sul2, tet (A), and qnrB19 in a clonal emergent Salmonella Minnesota lineage in Brazil, along with a novel megaplasmid pESM carrying resistance and virulence factors.
Virulence and Antimicrobial Resistance Patterns of Salmonella spp. Recovered From Migratory and Captive Wild Birds.
The study identified the presence of AMR genes blaTEM, blaSHV, sul1, and tet(A) in Salmonella spp. recovered from migratory and captive wild birds, highlighting the potential for these birds to act as reservoirs of multidrug-resistant bacteria.
Molecular characterization of the tet (M)-carrying transposon Tn7124 and plasmids in Escherichia coli isolates recovered from swine.
The study identifies the tet(M)-carrying transposon Tn7124 and plasmids pTA2 and pTA7 in E. coli isolates from swine, highlighting the presence of multiple antibiotic resistance genes such as tet(M), tet(A), floR, aadA1, cmlA1, aadA2, sul3, qnrS1, bleO, and oqxAB.
Combatting extensively drug-resistant Salmonella: a global perspective on outbreaks, impacts, and control strategies.
The paper discusses the emergence and global spread of extensively drug-resistant (XDR) Salmonella, highlighting the resistance mechanisms involving genes such as blaCTX-M-15, floR, cat1, cat2, strA, strB, aacC(3), aadA, ant(3")-Ia, aph(3)-IIa, tet(A), tet(B), tet(D), tet(G), tet(H), dfrA10, dhfrXII, sul1, sul2, sul3, mphA, and ermB.
A nosocomial outbreak of colistin and carbapenem-resistant hypervirulent Klebsiella pneumoniae in a large teaching hospital.
Survey in ruminants from Rwanda revealed high diversity and prevalence of extended-spectrum cephalosporin-resistant Enterobacterales.
The study identified various extended-spectrum cephalosporin-resistant Enterobacterales in ruminants from Rwanda, including multiple beta-lactamase genes such as bla CTX-M-15, bla TEM-1, and others, along with non-beta-lactam resistance genes like tet(A), sul2, and qnrS1.
Genomic epidemiology and phenotypic characterisation of Salmonella enterica serovar Panama in Victoria, Australia.
The study identifies the first plasmid-mediated colistin-resistant Salmonella enterica serovar Panama in Australia, highlighting the emergence of multidrug resistance in this invasive non-typhoidal Salmonella serovar.
Escherichia coli from six European countries reveals differences in profile and distribution of critical antimicrobial resistance determinants within One Health compartments, 2013 to 2020.
The study identified various AMR genes in E. coli isolates from different sources in six European countries, highlighting differences in resistance profiles and the prevalence of specific resistance mechanisms such as beta-lactamases, quinolone resistance genes, and tetracycline resistance genes.
Florfenicol administration in piglets co-selects for multiple antimicrobial resistance genes.
Florfenicol administration in piglets leads to the selection of multiple antimicrobial resistance genes, including those conferring resistance to phenicols, aminoglycosides, beta-lactams, sulfonamides, and oxazolidinones.
Comparative genomics analysis of Salmonella Enteritidis isolated from clinical cases associated with chicken.
Five Salmonella Enteritidis isolates were analyzed, revealing multiple antimicrobial resistance genes and chromosomal mutations. Key resistance genes included bla CTX−M−55, bla TEM−141, bla TEM−1B, aac(6')-Iaa, aph(3’)-IIa, aph(3’’)-Ib, aph(6)-Id, tet(A), floR, fosA3, and sul2. Chromosomal mutations in gyrA (D87G/D87Y) and acrB (F28L/L40P) were also identified, contributing to fluoroquinolone and multidrug resistance.
Multidrug-resistant ESBL-producing Klebsiella pneumoniae complex in Czech hospitals, wastewaters and surface waters.
The study identified multidrug-resistant Klebsiella pneumoniae complex isolates carrying various beta-lactamase genes such as bla CTX-M-15, bla GES-51, bla OXA-48, bla NDM-1, and bla KPC-3, along with other resistance genes like oqxA, oqxB, sul2, aph(6)-Id, dfr14, qnrB1, and aac(6')-Ib-cr.
Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307.
The study identifies the colistin resistance gene mcr-8.1 in multidrug-resistant Klebsiella pneumoniae ST307 isolates from Armenia, highlighting the emergence of this gene in the region.
Exploring the genomic and antimicrobial resistance tapestry: comparative insights into Salmonella enterica serotypes Agona, Braenderup, Muenchen, and Panama in Latin American surface waters.
The study identifies several AMR genes, including fosA7.2, qnrB19, aadA1, floR, sat2, tet(B), and tet(A), in Salmonella enterica serotypes Agona, Braenderup, Muenchen, and Panama from Latin American surface waters, highlighting the prevalence of multidrug resistance in these isolates.
Characterizing Methicillin-Resistant Staphylococcus spp. and Extended-Spectrum Cephalosporin-Resistant Escherichia coli in Cattle.
The study identified several AMR genes in E. coli and MRSA isolates from cattle in Austria, including bla CTX-M-1/15, bla CTX-M-9, bla TEM, tet (A), tet (B), dfrA1, dfrA5, dfrA14, dfrA17, sul2, sul3, aadA1, aadA2, floR, cmlA, aphA, and bla ACT. Additionally, the MRSA isolate carried the mecA gene, indicating methicillin resistance.
Genomic and virulent characterization of a duck-associated Salmonella serovar Potsdam from China.
The study identified several antimicrobial resistance genes and mutations in Salmonella serovar Potsdam isolated from duck embryos, including aac(3')-Ia, aac(4')-IIa, aph(3')-IIa, aph(3')'-Ib, aph(6')-Id, blaTEM-116, blaTEM-1B, and tet(A), as well as gyrA and parC mutations associated with quinolone resistance.
Phenotypic and genotypic landscape of antibiotic resistance through One Health approach in Sri Lanka: A systematic review.
The study identifies several antibiotic resistance genes, including tet-A, blaCTX-M, and blaSHV, which are prevalent in Escherichia coli and Klebsiella pneumoniae in Sri Lanka. These genes contribute to resistance against various antibiotics such as tetracycline, ceftazidime, ceftriaxone, and cefotaxime.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic Escherichia coli and Staphylococcus aureus Strains?
The study identified several antibiotic resistance genes in clinical strains of Staphylococcus aureus and Escherichia coli, including blaZ, grlA, grlB, gyrA, mecA, ermC, aph(6)-Id, aph(3")-Ib, aadA5, blaCTX-M-27, mph(A), sul1, sul2, tet(A), and dfrA17. These genes confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, aminoglycosides, sulfonamides, tetracyclines, and macrolides.
Multidrug-resistant ST11-KL64 hypervirulent Klebsiella pneumoniae with multiple bla- genes isolated from children's blood.
Dynamics of Salmonella Dublin infection and antimicrobial resistance in a dairy herd endemic to salmonellosis.
The study identified the presence of florR and cmlA1 genes responsible for phenicol resistance, and blaTEM-1A associated with beta-lactam resistance in Salmonella enterica serovar Dublin isolates from cattle in California.
Whole Genome Sequencing and Comparative Genomics Analysis of Goat-Derived Klebsiella oxytoca.
The study identified 448 drug resistance genes in the goat-derived K. oxytoca strain KOHN1, including genes conferring resistance to beta-lactams, tetracyclines, fluoroquinolones, and fosfomycins. It also identified 146 virulence genes, including vgrG, hcp, clpV, and fimA.
Molecular Epidemiology and In-Depth Characterization of Klebsiella pneumoniae Clinical Isolates from Armenia.
The study identifies multiple AMR genes and mutations in K. pneumoniae isolates from Armenia, highlighting the presence of XDR and MDR strains with resistance to various antibiotics, including carbapenems, aminoglycosides, and quinolones.
Risk assessment and photo-disinfection of antibiotic residues and antibiotic-resistant bacteria in water sources from Ede, Nigeria.
The study identified antibiotic residues and antibiotic-resistant bacteria (ARB) in various water sources in Ede, Nigeria, highlighting the presence of multidrug-resistant (MDR) bacteria such as Bacillus spp. and Staphylococcus. It also assessed the ecological and health risks associated with these residues and proposed a photocatalytic material for water disinfection.
Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from retail markets in Yichun city, China, including genes conferring resistance to various antibiotics such as chloramphenicol, tetracycline, trimethoprim, and extended-spectrum beta-lactamases.
Whole-genome sequencing of Acinetobacter baumannii clinical isolates from a tertiary hospital in Terengganu, Malaysia (2011-2020), revealed the predominance of the Global Clone 2 lineage.
The study identified the predominance of the Global Clone 2 lineage of Acinetobacter baumannii in Terengganu, Malaysia, with a focus on the detection of various antimicrobial resistance genes, including bla OXA-23, bla ADC, bla NDM-1, and others, contributing to multidrug resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Genomic characterization of foodborne Salmonella enterica and Escherichia coli isolates from Saboba district and Bolgatanga Municipality Ghana.
The study identified fosfomycin resistance gene fosA7.2 in Salmonella enterica and tetracycline resistance gene tet(A) in Salmonella enterica and Escherichia coli.
Genomic analysis of Enterobacter cloacae complex from Southern Thailand reveals insights into multidrug resistance genotypes and genetic diversity.
The study identified multiple antimicrobial resistance genes in Enterobacter cloacae complex isolates from Southern Thailand, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and efflux pumps. Notably, the mcr-9 gene was found to confer colistin resistance.
Tracing the evolution: the rise of Salmonella Thompson co-resistant to clinically important antibiotics in China, 1997-2020.
The study identifies the IncC plasmid as a major driver of co-resistance to ciprofloxacin, cefotaxime, and azithromycin in Salmonella Thompson isolates in China, with specific resistance genes including qnrS1, qepA4, blaCMY-2, and mph(A).
Abundance of clinically relevant antimicrobial resistance genes in the golden jackal (Canis aureus) gut.
The study identified a high prevalence of clinically relevant antimicrobial resistance genes in golden jackals, including beta-lactamases (bla TEM-1, bla CTX-M-15, bla SHV), quinolone resistance (qnrS), and class 1 integrons (Int1).
Genomic epidemiology and antimicrobial resistance of Morganella clinical isolates between 2016 and 2023.
The study identified several AMR genes in Morganella clinical isolates, including tet(B), sul1, catA2, sul2, floR, aadA1, and others, contributing to resistance against various antibiotics.
Eradication of Helicobacter pylori reshapes gut microbiota and facilitates the evolution of antimicrobial resistance through gene transfer and genomic mutations in the gut.
H. pylori eradication led to the enrichment of various AMR genes, including beta-lactamases, macrolide phosphotransferases, erythromycin ribosome methyltransferases, sulfonamide resistance proteins, tetracycline efflux pumps, dihydrofolate reductase, quaternary ammonium compound efflux pumps, and aminoglycoside phosphotransferases. Additionally, genomic mutations in parC, parE, and gyrA were associated with fluoroquinolone resistance in E. coli.
Exogenous plasmid capture to characterize tetracycline-resistance plasmids in sprouts obtained from retail in Germany.
The study identified tetracycline resistance genes tet(A) and tet(D), along with quinolone, sulfonamide, and trimethoprim resistance genes qnrS1, sul1, and dfrA1 in plasmids from sprout samples.
Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.
This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.
Epidemic trend of Salmonella from swines and broilers in China from 2014 to 2023 and genetic evolution analysis of ESBLs-producing strains.
The study identified several AMR genes in ESBL-producing Salmonella strains from swines and broilers in China, including blaCTX-M-14, blaTEM-1B, blaCTX-M-65, aac(6')-Iaa, floR, sul2, tet(B), arr-2, fosA3, dfrA12, mph(A), lnu(F), blaCTX-M-55, blaOXA-1, sul1, tet(A), catB3, qnrS1, and mcr-1.1. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, sulfonamides, tetracyclines, rifampicin, fosfomycin, trimethoprim, macrolides, lincomycin, quinolones, and colistin.
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
The study identified various AMR genes and mutations in Salmonella Enteritidis isolates from Spain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and aminoglycoside resistance genes. Chromosomal mutations in the gyrA gene were also found to contribute to quinolone resistance.
Wastewater based genomic surveillance key to population level monitoring of AmpC/ESBL producing Escherichia coli.
The study identified various AMR genes and mutations in AmpC/ESBL-producing E. coli from wastewater samples in Finland, highlighting the prevalence of blaCTX-M-15, blaCTX-M-27, and other resistance determinants.
Avian-specific Salmonella transition to endemicity is accompanied by localized resistome and mobilome interaction.
The study identifies several antimicrobial resistance genes, including bla TEM-1B, sul2, and tet(A), which are prevalent in Salmonella enterica serovar Gallinarum isolates. These genes contribute to the resistome diversity and are associated with specific lineages and geographical regions.
Molecular epidemiology of a multidrug-resistant Shigella sonnei outbreak in Tunisia (2022-2023) using whole-genome sequencing.
The study identifies multiple AMR genes and mutations in a multidrug-resistant Shigella sonnei outbreak in Tunisia, including blaCTX-M-15, dfrA1, qnrS1, sul2, tet(A), mph(A), and blaTEM-35, along with the D87Y mutation in gyrA.
Detection of a genetically related carbapenemase-producing Escherichia coli ST167 in clinical and environmental isolates: Evidence for clonal spread of carbapenemase-producing Enterobacteriaceae in humans and the environment in Iowa, United States.
The study identifies a carbapenemase-producing E. coli strain BO1 carrying bla NDM-5, along with other resistance genes, highlighting the clonal spread of carbapenemase-producing Enterobacteriaceae between humans and the environment in Iowa.
Whole-genome sequencing-based species classification, multilocus sequence typing, and antibiotic resistance mechanisms of the clinical Aeromonas complex.
The study identified multiple beta-lactamase genes, including bla NDM-1, bla PER-3, and bla OXA-1, along with other resistance genes such as aac(6′)-Ib-cr6, aph(3″)-Ib, and floR, which contribute to resistance against various antibiotics in Aeromonas isolates.
Carbapenem-Resistant, Virulence Plasmid-Harboring Klebsiella pneumoniae, United States.
The study identifies six pVir-CRKP isolates from the United States, highlighting their multidrug resistance and enhanced virulence traits. These isolates exhibit resistance to various antibiotics, including carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, due to the presence of specific AMR genes and mutations.
Genomic insights into extended-spectrum β-lactamase- and plasmid-borne AmpC-producing Escherichia coli transmission between humans and livestock in rural Cambodia.
The study identifies a wide range of AMR genes, including bla CTX-M, bla TEM, tet(A), sul2, aph(3'')-Ib, aac(6')-Ib-cr, qnrS1, lnu(F), mph(A), and mcr-1.1, in ESC-Ec strains from humans and livestock in rural Cambodia, highlighting the transmission of these genes between hosts.
Genetic compatibility and ecological connectivity drive the dissemination of antibiotic resistance genes.
The study identifies and characterizes various antibiotic resistance genes (ARGs) involved in horizontal gene transfer, highlighting the role of genetic compatibility and ecological connectivity in the dissemination of these genes.
Isolation, Identification, and Characteristics of Aeromonas salmonicida subsp. masoucida from Diseased Starry Flounder (Platichthys stellatus).
The study identified 11 antimicrobial resistance genes in Aeromonas salmonicida subsp. masoucida strains isolated from diseased starry flounders, including genes conferring resistance to beta-lactams, tetracyclines, sulfonamides, chloramphenicol, and biocides.
Polyclonal carbapenemase-producing Escherichia coli in Northern Italy: the emergence of NDM-7.
The study identifies the emergence of NDM-7 in polyclonal carbapenemase-producing E. coli in Northern Italy, highlighting the presence of various carbapenemase genes such as bla KPC-3, bla VIM-1, and bla NDM-7, along with other resistance genes.
Comprehensive genomic epidemiology and antimicrobial resistance profiles of clinical Klebsiella pneumoniae species complex isolates from a tertiary hospital in Wenzhou, China (2019-2021).
The study identified a variety of antimicrobial resistance genes in clinical Klebsiella pneumoniae species complex isolates, including bla KPC−2, bla CTX−M, bla SHV, aac(6')-Ib, aadA1, aadA2, aph(3')-Ia, oqxAB, qnrB19, qnrS1, tet(A), tet(D), sul1, sul2, sul3, cmlA1, floR, fosA, and fosA3. These genes confer resistance to multiple classes of antibiotics, highlighting the complexity of antimicrobial resistance in these isolates.
Genomic features, antimicrobial resistance and pathogenicity assessment of Escherichia coli serotype O177:H51 strain JS01 isolated from a diseased chicken.
The study identified 64 AMR genes and 177 virulence factor genes in the E. coli strain JS01, highlighting its multidrug resistance and high pathogenicity.
The investigation of molecular epidemiological characteristics and resistance mechanism of tigecycline resistant Klebsiella pneumoniae from a large teaching hospital in southwest China, Chongqing.
The study identified ramR, acrR, oqxR, and tet(A) as key genes contributing to tigecycline resistance in Klebsiella pneumoniae. Mutations in ramR, such as A19V, K63M, and I141T, were prevalent and associated with increased resistance. The tet(A) gene, particularly type 1 and type 3 variants, played a significant role in tigecycline resistance.
Genomic insights and epidemiology of mcr-1-Carrying Escherichia albertii isolated from agricultural soil in China.
The study identifies an Escherichia albertii strain (6S-65-1) carrying the mcr-1 gene, which confers resistance to polymyxins. Additional resistance genes such as aph(3')-Ia, aadA1, aadA2b, cmlA1, sul3, tet(A), and bleO were also found, contributing to multidrug resistance.
Recent emergence of cephalosporin-resistant Salmonella Typhi in India due to the endemic clone acquiring IncFIB(K) plasmid encoding bla (CTX-M-15) gene.
The study identifies the emergence of a new clone of ceftriaxone-resistant Salmonella Typhi in India, which acquired an IncFIB(K) plasmid encoding the bla(CTX-M-15) gene, along with other resistance determinants such as qnrS1, sul2, dfrA14, tet(A), aph(3"), and aph(6').
Phenotypic and Genomic Assessment of Antimicrobial Resistance and Virulence Factors Determinants in Salmonella Heidelberg Isolated from Broiler Chickens.
The study identified high levels of antimicrobial resistance in Salmonella Heidelberg strains from broiler chickens in Brazil, with resistance genes tet(A), sul2, fosA7, and aac(6')-Iaa, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Antimicrobial susceptibility trends of S. Typhi and S. Paratyphi in a post-COVID-19 pandemic India, from a multicenter surveillance network.
The study identified several antimicrobial resistance genes including blaCTX-M-15, qnrS1, sul2, dfrA14, and tet(A) in ceftriaxone-resistant S. Typhi isolates. A S83F mutation in gyrA was associated with reduced susceptibility to ciprofloxacin.
Genomic epidemiology of Salmonella Enteritidis human infections in the Netherlands, 2019 to 2023.
The study identified several AMR genes and mutations in Salmonella Enteritidis isolates from the Netherlands, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and quinolone resistance proteins, as well as specific gyrA mutations associated with (fluor)quinolone resistance.
Isolation, Antimicrobial Susceptibility, and Genotypes of Three Pasteurellaeae Species Prevalent on Pig Farms in China Between 2021 and 2023.
The study identified 18 antimicrobial resistance genes in three Pasteurellaeae species, including tetracycline, beta-lactam, sulfonamide, aminoglycoside, and macrolide resistance genes. High frequencies of tet(L), tet(M), tet(A), blaTEM, sul2, aph(3')-Ia, dfrA12, qnrS1, strA, sul3, and mef(B) were observed.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Mobile genetic elements in Klebsiella pneumoniae.
The paper characterizes several AMR genes including bla KPC, bla NDM-5, mcr-1, mcr-7, mcr-8, tet(X), and tmexCD1-toprJ1, highlighting their role in carbapenem, colistin, and tigecycline resistance in Klebsiella pneumoniae.
First report of multidrug-resistant and pathogenic Plesiomonas shigelloides from endangered crested ibis (Nipponia nippon).
The study reports the first isolation of multidrug-resistant and pathogenic Plesiomonas shigelloides from the endangered crested ibis, highlighting the presence of resistance genes such as blaTEM, aac(6')-Ib3, aac(6')-Ib-cr, mph(A), arr-2, tet(A), qacEΔ1, dfrA1, and sulI.
Genome-Based Molecular Diversity of Extended-Spectrum β-Lactamase-Producing Escherichia coli From Pigeons in China.
The study identifies multiple extended-spectrum β-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla OXA, bla LAP, and bla CMY, as well as other antibiotic resistance genes such as mcr-1, mcr-1.1, tet(X4), aadA1, aadA2, aph(6)-Id, aph(3")-Ib, aph(3')-Ia, aph(3')-IIa, aac(3)-IVa, aph(4)-Ia, tet(A), tet(M), sul2, sul3, dfrA14, qnrS1, arr-2, fosA3, cmlA5, floR, mph(A), and lnu(F) in ESBL-producing E. coli isolates from pigeons in China.
Coagulase-Negative Staphylococci Determined as Blood Culture Contamination Have High Virulence Characteristic Including Transfer of Antibiotic Resistance Determinants to Staphylococcus aureus and Escherichia coli.
The study identified several AMR genes in coagulase-negative staphylococci (CoNS) that are capable of transferring antibiotic resistance to both Staphylococcus aureus and Escherichia coli. These genes include bla, aac(6')-Ib, tet(M), and qnrS1.
Molecular characterization of multidrug-resistant E. coli recovered from diarrheagenic children under 5 years from Mukuru Informal Settlement, Nairobi, Kenya, based on whole-genome sequencing analysis.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from diarrheagenic children in Nairobi, Kenya, highlighting the presence of blaTEM-1B, blaCTX-M-15, qnrS1, qnrB4, aac(6')-Ib-cr, and other resistance mechanisms.
Occurrence and Genotypic Characterization of Selected Multidrug-resistant ESKAPE-E Pathogens Isolated from Integrated Smallholder Fresh Produce Farms.
The study identified several AMR genes, including mcr-9 (colistin resistance), blaOXA-like and blaPAO-like (beta-lactam resistance), catB (chloramphenicol resistance), sul (sulfonamide resistance), tet(A) (tetracycline resistance), mdf(A)_1 (macrolide resistance), and formA (formaldehyde resistance) in various ESKAPE-E pathogens isolated from smallholder farms in South Africa.
The pet café is a neglected site for transmission of antimicrobial-resistant Escherichia coli in urban life.
The study identifies multiple antimicrobial resistance genes (ARGs) in Escherichia coli isolates from pet cafés, highlighting the role of plasmids in the transmission of these genes. Key ARGs include tet(X4), sul2, sul3, strA, strB, dfrA14, qnrS1, qnrS2, oqxB, blaCTX-M-15, blaCTX-M-14, blaCTX-M-65, floR, and tet(A).
Comprehensive analysis of extensive drug-resistant Salmonella Typhi in Gujarat region, India: genomic findings and prospective alternative therapy.
The study identified multiple AMR genes and mutations in extensive drug-resistant Salmonella Typhi isolates from Gujarat, India, including aph(3'')-Ib, aph(6)-Id, bla CTX-M, dfrA14, qnrS1, sul2, tet(A), mdtK, and gyrA mutations, contributing to resistance against various antibiotics such as tetracycline, fluoroquinolones, and beta-lactams.
Agriculturally Sourced Multidrug-Resistant Escherichia coli for Use as Control Strains.
The study identifies two agriculturally sourced E. coli strains, ARS-C301 and ARS-C101, as control strains for antibiotic resistance research. ARS-C301 exhibits ESBL positivity and tetracycline resistance, harboring the CTX-M-55 beta-lactamase and tet(A) tetracycline efflux pump genes. ARS-C101 is ESBL-negative and tetracycline-susceptible.
Clonal dissemination and persistence of Carbapenem-resistant bla (KPC-2) harbouring Klebsiella pneumoniae ST307 in a Tertiary Hospital in the Republic of Korea.
Dogs fed raw meat-based diets are vectors of drug-resistant Salmonella infection in humans.
Genomic insights into antibiotic-resistant non-typhoidal Salmonella isolates from outpatients in Minhang District in Shanghai.
The study identifies multiple antibiotic resistance genes and mutations in non-typhoidal Salmonella isolates from Minhang District, Shanghai, highlighting the prevalence of multidrug-resistant strains and the role of specific genetic elements in resistance mechanisms.
Synergy of Tetracyclines and Potassium Azeloyl Diglycinate (Azeloglycine) in Hydrogels: Evaluation of Stability, Antimicrobial Activity, and Physicochemical Properties.
The study evaluated the stability and antimicrobial activity of hydrogels containing tetracycline and chlortetracycline, with and without azeloglycine. All formulations showed antimicrobial activity against Staphylococcus aureus, and azeloglycine improved the stability of tetracycline in alkaline conditions.
Genomic analysis of Salmonella enterica from cattle, beef and humans in the Greater Tamale Metropolis of Ghana.
Four raw beef isolates harbored at least one gene conferring resistance to beta-lactam (blaTEM-1), chloramphenicol (catA), fosfomycin (fosA7), quinolone (qnrD1), or tetracycline (tet(A)).
Genomic insights into multidrug - resistant Salmonella enterica isolates from pet dogs and cats.
The study identified multiple AMR genes in multidrug-resistant Salmonella enterica isolates from pet dogs and cats, including aac(6')-Iaa, aadA1, aadA2, blaTEM-1B, qacL, sul3, tet(A), qnrS1, fosA7, dfrA12, cmlA1, aph(3')-Ib, aph(6)-Id, blaCTX-M-55, blaTEM-215, and floR, which confer resistance to various antibiotics such as ampicillin, tetracycline, sulfamethoxazole, ciprofloxacin, and chloramphenicol.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Prevalence, aetiology and host and management factors associated with bovine mastitis in dairy cows in Zoba Anseba, Eritrea: a cross-sectional study.
The study identified tetracycline, sulfonamide, and penicillin resistance in Staphylococcus aureus, Enterococcus faecium, and Streptococcus agalactiae isolates from dairy cows in Eritrea.
Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica.
The study identified several AMR genes in E. coli isolates from two sloth species in Costa Rica, including blaTEM-1B, aph(3')-Id, aph(6)-Id, tet(A), tet(B), sul2, qnrS1, floR, and dfrA8, which were associated with resistance to various antibiotics.
Antimicrobial resistance and biofilm formation in rarely reported Salmonella enterica serovars from patients presenting with gastroenteritis in Nairobi, Kenya.
Three Salmonella Newport isolates carried acquired antimicrobial resistance genes, including bla TEM −1 , tet(A), aph(6)-Id, dfrA14, and sul2. These genes conferred resistance to ampicillin, tetracycline, trimethoprim-sulfamethoxazole, and gentamicin.
Antimicrobial resistance and virulence gene profiles of Escherichia coli isolated from poultry farms using One Health perspective in Abeokuta, Nigeria.
The study identified 30 different resistance determinants in 14 whole genome sequenced E. coli isolates from poultry farms in Abeokuta, Nigeria. These included genes such as blaTEM-1B, blaCARB-2, aph(3'')-Ib, aph(6)-Id, floR, sul1, sul2, tet(A), and tet(B), among others, which conferred resistance to various antimicrobial classes.
Clonal spread of bla(CTX-M-65) producing Salmonella enterica serovars detected in poultry retail meat in North Carolina, USA.
The study identifies the clonal spread of bla(CTX-M-65) producing Salmonella enterica serovars in poultry retail meat in North Carolina, USA. It characterizes the resistance profiles of these isolates, including the presence of bla(CTX-M-65), aac(3)-Iva, aadA1, aph(4)-Ia, floR, mdsA, mdsB, sul1, tet(A), dfrA14, aph(3')-Ia, sul2, aph(3'')-Ib, and fosA3.
Population Structure, Genomic Features, and Antibiotic Resistance of Avian Pathogenic Escherichia coli in Shandong Province and Adjacent Regions, China (2008-2023).
The study identified multiple antibiotic resistance genes and mutations in Avian Pathogenic Escherichia coli (APEC) isolates from Shandong Province and adjacent regions in China, highlighting the high prevalence of multidrug resistance and the presence of specific resistance mechanisms such as beta-lactamases, tetracycline resistance genes, and fluoroquinolone resistance mutations.
Genomic characterization and global relatedness of multidrug-resistant Salmonella Goldcoast ST2529.
The study identifies the bla NDM-1 gene in a multidrug-resistant Salmonella Goldcoast ST2529 strain, which confers resistance to multiple beta-lactam antibiotics, chloramphenicol, tetracycline, and fluoroquinolones. The gene is located on an IncFII-type plasmid and was successfully transferred via conjugation.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
The study identified 50 acquired resistance genes and seven chromosomal-mediated gene mutations in Salmonella populations from Thai canal water, highlighting the prevalence of multidrug-resistant strains and the diversity of resistance mechanisms.
Ecological connectivity of genomic markers of antimicrobial resistance in Escherichia coli in Hong Kong.
The study identifies various antimicrobial resistance genes in E. coli isolates from Hong Kong, including blaTEM-1, floR, tet(A), aph(3')-Ia, blaNDM, tet(X4), and mcr, which confer resistance to multiple antibiotics.
Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria.
The study characterizes several AMR genes, including blaIPM-4, blaOXA-1, blaOXA-10, aacA4, blaOXA-101, aadA11, aadA9, qacEΔ1, sat2-aadA1, and others, highlighting their role in conferring resistance to various antibiotics in different bacterial species.
Cefiderocol-resistant pathogens in German hospital wastewater: a reservoir for multidrug resistance.
The study identifies multiple AMR genes, including bla NDM−1, bla VIM−1, bla OXA−48, and bla KPC−2, in cefiderocol-resistant isolates from German hospital wastewater, highlighting the presence of multidrug-resistant pathogens with diverse resistance mechanisms.
Natural Microbiota of Dogs and Cats as a Source and Vector of Resistance Genes-Clinical Significance.
The study identifies tetracycline resistance genes (tet(Q), tet(A)), macrolide resistance genes (mef(A), erm(B), erm(F)), and lincosamide resistance gene (lnu(C)) in the natural microbiota of dogs and cats, highlighting their potential as vectors for antimicrobial resistance.
Antimicrobial Resistance of Salmonella and Characterization of Two Mcr-1-Harboring Isolates from Pork Products in Guangdong, China.
Two mcr-1-harboring Salmonella Kentucky ST198 isolates were identified, showing resistance to multiple antibiotics including colistin, tetracycline, and fluoroquinolones. The study highlights the presence of complex resistance determinants such as the multidrug resistance region (MRR) and SGI1-KI.
Evidence of ESBL plasmid transfer and selective persistence of multiple host-associated Escherichia coli isolates in a chicken cecal fermentation model.
The study identifies multiple ESBL-producing E. coli isolates and characterizes their resistance genes, highlighting the transfer of bla CTX-M-1 plasmids among isolates in a chicken cecal fermentation model.
Molecular epidemiology of pESI-carrying Salmonella Infantis in Korea: insights from a one health framework.
The study identifies multiple antimicrobial resistance genes and a quinolone resistance mutation in pESI-carrying Salmonella Infantis isolates from the Korean poultry production chain, highlighting the potential for zoonotic transmission.
Molecular Characteristics of Epidemiologically Successful Salmonella Enteritidis in Poland.
The study identified several AMR genes and mutations in Salmonella Enteritidis strains, including qnrB19, blaTEM-1, blaTEM-135, tet(A), sul2, and mutations in gyrA (S83Y, D87Y, S83F, S464Y).
Unveiling community structure, antimicrobial resistance, and virulence factor of a wastewater sample of dairy farm located in mayurbhanj, odisha, india.
The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Whole-Genome Sequencing Uncovers Chromosomal and Plasmid-Borne Multidrug Resistance and Virulence Genes in Poultry-Associated Escherichia coli from Nigeria.
The study identified multiple antimicrobial resistance genes in a multidrug-resistant E. coli strain from poultry in Nigeria, including blaCTX-M-15, blaOXA-1, blaTEM-1, aac(6')-Ib-cr, aadA5, aph(3'')-Ib, sul1, sul2, tet(A), mph(A), and dfrA17, highlighting the role of plasmids in the spread of resistance.
Molecular Epidemiology of tet(A)-v1-Positive Carbapenem-Resistant Klebsiella pneumoniae in Pediatric Patients in a Chinese Hospital.
The study identifies the tet(A)-v1 gene as a significant factor in tigecycline resistance among carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from pediatric patients. It also characterizes various carbapenemase genes, including bla IMP-4, bla NDM-5, bla NDM-1, and bla KPC-2, contributing to carbapenem resistance.
Antimicrobial Resistance and Genomic Characterization of an Escherichia coli Strain Harboring p0111 and an IncX1-Type Plasmid, Isolated from the Brain of an Ostrich.
The study identifies multiple antimicrobial resistance genes in an Escherichia coli strain isolated from an ostrich, including bla CTX-M-55, rmtB, sul1, APH(6)-Id, tet(A), AAC(3)-IIc, aadA2, bla TEM-1B, and floR, which confer resistance to various antibiotics such as cephalosporins, aminoglycosides, sulfonamides, tetracyclines, and chloramphenicol.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
The study identifies 42 antimicrobial resistance (AMR) genes in the pan-drug resistant Klebsiella pneumoniae isolate KPNW, including beta-lactamases (bla CTX-M-15, bla NDM-1, bla OXA-1, bla TEM-63, bla TEM-104, bla SHV-28), tetracycline resistance genes (tet(A)), and efflux pump genes (oqxA, oqxB, marA, marR, ompK37, pbp3, crp, h-ns, kpnG, kpnH, parC, rsmA). Additionally, the isolate shows resistance to polymyxin B and colistin through modifications in lipid A (eptB, arnT, lptD, msbA, vanG) and other mechanisms.
Molecular characterization of drug-resistance genes and dynamics of multidrug-resistant Salmonella spp. in waterfowl: a pre- and post-antibiotic ban surveillance in Guangdong, China from 2013 to 2023.
The study identified several AMR genes in Salmonella isolates from waterfowl in Guangdong, China, including bla CTX-M, bla TEM, bla OXA, aad A1, aad A2, aac C2, aac (3)-IV, aph (3’)-I, qnr A, qnr S, clm A, flo R, tet (A), and Sul II. These genes were associated with resistance to various antibiotics such as β-lactams, aminoglycosides, quinolones, chloramphenicol, tetracyclines, and sulfonamides.
Combined pesticide pollution enhances the dissemination of the phage-encoded antibiotic resistome in the soil under nitrogen deposition.
The study identifies several phage-encoded antibiotic resistance genes (ARGs) that are enhanced under combined pesticide pollution and nitrogen deposition, including macB, tet(A), efrB, msbA, and ugd, which confer resistance to macrolides, tetracyclines, multidrug, and polymyxin.
Whole-genome sequencing reveals Enterobacter hormaechei as a key bloodstream pathogen in six tertiary care hospitals in southwestern Nigeria.
The study identifies several AMR genes in Enterobacter hormaechei and Enterobacter cloacae, including bla ACT-45, bla CTX-M-15, bla NDM-1, dfrA14, mcr10.1, aac(3)-Ile, aph(3′)-Ib, qnrB1, sul1, sul2, tet(A), catA1, and mphA, highlighting the prevalence of multidrug resistance in these species.
No evidence of multidrug-resistant Enterobacterales transmission between healthy companion animals and pet owners in the greater Atlanta area: a pilot study.
The study identified several AMR genes and mutations in E. coli isolates from both humans and pets, including blaCMY-2, blaCTX-M-15, blaTEM-1B, and mutations in gyrA and parC. These findings highlight the presence of multidrug-resistant Enterobacterales in healthy individuals and their companion animals.
Persistent multispecies dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital.
The study identifies the persistent dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital, highlighting the role of these plasmids in the spread of aminoglycoside resistance.
Diversity and antimicrobial resistance among bacterial isolates from finfish aquaculture in Thailand.
The study identified high levels of antimicrobial resistance in bacterial isolates from finfish aquaculture in Thailand, with particular emphasis on beta-lactam, tetracycline, and fluoroquinolone resistance in Gram-negative bacteria, and beta-lactam, macrolide, fluoroquinolone, and peptide resistance in Gram-positive bacteria. Unique resistance gene families, such as the SMR efflux pump and OXA beta-lactamase, were found in Aeromonas spp. and V. vulnificus.
Community gut colonization by tet(X4)-positive multidrug-resistant Escherichia coli in healthy individuals from urban residents in Shenzhen, China.
The study identifies tet(X4)-positive multidrug-resistant E. coli in healthy individuals from urban areas in Shenzhen, China, highlighting the presence of tigecycline resistance and other resistance genes in the community gut microbiota.
Genomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
The study identified high levels of antimicrobial resistance in Shigella boydii, with over 60% of isolates classified as multidrug-resistant. Key resistance genes included blaCTX-M-15, blaCTX-M-3, blaDHA-1, mphA, sul1, sul2, dfrA1, dfrA14, dfrA5, dfrA12, dfrA17, dfrA7, aadA1, aph(3’’)-Ib, aph(6)-Id, tet(A), and tet(B). Mutations in gyrA and parC were associated with ciprofloxacin resistance and reduced susceptibility.
Genomic insights into Shigella species isolated from small ruminants and manure in the North West Province, South Africa.
The study identified multiple antibiotic resistance genes in Shigella species isolated from small ruminants and manure in South Africa, highlighting the presence of multidrug-resistant strains and the diversity of resistance mechanisms.
Global genomic survey of Salmonella Kentucky: discovery of a chromosomeborne bla(NDM-5) and the emergence of ST314, an MDR clone mediated by the IncR plasmid.
The study discovered a chromosome-borne bla(NDM-5) gene in Salmonella Kentucky and identified the IncR plasmid as a key mediator of antimicrobial resistance in the MDR clone ST314.
Assessing the Genomic Landscape of Salmonella enterica Isolated From Cattle Faeces on a Nigerian Farm.
The study identified AMR genes in Salmonella enterica isolates from cattle faeces, including aph(3')-Id, aph(6)-Id, qnrB19, sul2, tet(A), and fosA7, which confer resistance to aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and fosfomycin.
Analysis of avian pathogenic Escherichia Coli (APEC) and its antimicrobial resistance risk characteristics and critical control points in laying hens.
The study identified several AMR genes in APEC isolates, including tet(A), floR, sul2, aph(3')-Ib, aph(6)-Id, bla TEM-1B, qnrS1, bla CTX-M-55, dfrA14, and mph(A), which contribute to resistance against tetracyclines, florfenicol, sulfonamides, aminoglycosides, beta-lactams, fluoroquinolones, and macrolides.
Multidrug resistant hypervirulent ST307 clone from genomic surveillance of extended spectrum beta-lactamase-producing Klebsiella pneumoniae species complex in East Africa.
The study identifies multiple AMR genes, including blaCTX-M-15, blaTEM-1D, aac(6')-Ib-cr, aadA16, strB, qnrS1, sul2, sul1, catII.2, tet(A), dfrA14, arr-3, and mphA, in ESBL-KpSC isolates from East Africa, highlighting the prevalence of multidrug resistance.
Multidrug resistant hypervirulent ST307 clone from genomic surveillance of extended spectrum beta-lactamase-producing Klebsiella pneumoniae species complex in East Africa.
The study identifies multiple AMR genes, including blaCTX-M-15, blaTEM-1D, aac(6')-Ib-cr, aadA16, strB, qnrS1, sul2, sul1, catII.2, tet(A), dfrA14, arr-3, and mphA, in ESBL-KpSC isolates from East Africa, highlighting the prevalence of multidrug resistance.
Comparative assessment of annotation tools reveals critical antimicrobial resistance knowledge gaps in Klebsiella pneumoniae.
The study identifies various AMR genes and mutations in Klebsiella pneumoniae, highlighting knowledge gaps in existing annotation tools and databases for accurate resistance prediction.
Nanopore targeted sequencing in lower respiratory infections: a retrospective study on diagnostic applications, clinical characterization, and antimicrobial guidance.
The study identified 16 distinct AMR genes in 15 patients using NTS, highlighting the effectiveness of NTS in detecting resistance genes in ESKAPE pathogens.
Contribution of maternal gut carriage to neonatal acquisition of extended-spectrum beta-lactamase-producing Enterobacterales in Madagascar and Cambodia.
Maternal gut carriage contributes to only 16.5% of neonatal acquisition of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE), with blaCTX-M-15, blaCTX-M-55, blaCTX-M-27, blaNDM-5, blaNDM-1, sul2, aph(3')-Ib, aph(6)-Id, and tet(A) identified as key resistance determinants.
Global geographic and genomic epidemiology analysis of carbapenem-resistant Escherichia coli carrying bla(NDM-9).
The study characterizes bla NDM-9 -carrying carbapenem-resistant Escherichia coli (CREC) and identifies various antibiotic resistance genes (ARGs) contributing to multidrug resistance. It highlights the role of mobile genetic elements in the dissemination of bla NDM-9 and emphasizes the importance of surveillance for these high-risk clones.
Genomic characterisation of multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from various sources in Algeria, North Africa.
The study identified multiple AMR genes and chromosomal mutations in multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from Algeria, including bla TEM-1B, bla CTX-M-15, aac(3)-Id, aadA7, sul1, tet(A), mph(A), qnrB19, cmlA1, and floR, along with mutations in gyrA and parC genes that confer resistance to ciprofloxacin.
Temporal dynamics of the resistome in gilts raised in an organic operation in which semen used for artificial insemination is the primary source of antimicrobial exposure.
The study identified several tetracycline, aminoglycoside, and MLS resistance genes in the fecal microbiome of gilts, with no significant increases in ARG abundance following exposure to semen extenders containing antibiotics.
Genetic insights into antimicrobial resistance and virulence characteristics of Salmonella enterica isolated from Nile tilapia sourced from retail markets in Thailand.
The study identified multiple antimicrobial resistance (AMR) genes in Salmonella enterica isolates from Nile tilapia, including beta-lactamases (bla TEM−1B, bla CTX−M−55, bla CTX−M−14, bla LAP−2), quinolone resistance genes (qnrS1, qnrS13), tetracycline resistance genes (tet(A), tet(B), tet(M)), aminoglycoside resistance genes (aadA2, aph(3’’)-Ib, aph(6)-Id, aac(6’)-Ia), sulfonamide resistance genes (sul1, sul2, sul3), florfenicol resistance gene (floR), and efflux pump systems (mdsABC, mdtK).
Genomic characterization of two distinct Klebsiella pneumoniae strains in a fatal case of relapsed acute myelogenous leukemia: a case report.
The study identified two distinct Klebsiella pneumoniae strains, ST147 and ST967, with varying resistance profiles. ST147 isolates harbored multiple resistance genes including bla OXA−181, aadA, aadA5, bla CTX−M−15, bla OXA−1, bla SHV−11, bla TEM−1, sul1, qnrS1, and tet(A), while ST967 had a more limited resistome with aac(3)-IIa, bla SHV−27, and dfrA14.
Diversity of Multi-Drug Resistance Genes in Escherichia coli Isolated from Poultry in Southern Togo.
The study identified multiple AMR genes in E. coli isolates from poultry in southern Togo, including blaCTX-M-55, sul2, tet(A), floR, aph(6)-Id, aph(3")-Ib, gyrA, gyrB, parC, parE, pmrA, pmrB, folp, 23S, 16S-rrsB, 16S-rrsC, 16S-rrsH, ampC-promoter, rpoB, and mcr-1.1. These genes confer resistance to various antibiotics, highlighting the prevalence of multidrug resistance in poultry-associated E. coli.
PanARGMiner (Pan-Genomic Antimicrobial Resistance Gene Miner): An advanced feature selection framework for extracting key resistance genes from pan-genomic datasets.
PanARGMiner effectively identifies key resistance genes from pan-genomic datasets, including both known and novel AMR genes, across multiple bacterial species.
PanARGMiner (Pan-Genomic Antimicrobial Resistance Gene Miner): An advanced feature selection framework for extracting key resistance genes from pan-genomic datasets.
PanARGMiner effectively identifies key resistance genes from pan-genomic datasets, including both known and novel AMR genes, across multiple bacterial species.
Precise species identification and whole-genome sequencing analysis of Enterobacter cloacae complex causing bloodstream infections in China.
The study identified various AMR genes in Enterobacter cloacae complex (ECC) isolates, including bla ACT, bla NDM, and mcr-10, which confer resistance to beta-lactams, carbapenems, and polymyxins, respectively. It also found that E. roggenkampii was the most common species among carbapenem-resistant isolates and showed high resistance to both carbapenems and colistin.
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Infective endocarditis caused by Escherichia coli O25b:H4-B2-ST131: A case report providing genotypic, phenotypic, and phylogenetic insights.
The study identifies multiple antimicrobial resistance genes in an E. coli O25b:H4-B2-ST131 strain causing infective endocarditis, including blaCTX-M-15, blaOXA-1, aac(6')-Ib-cr, aac(3)-IIa, tet(A), and catB3, which confer resistance to various antibiotics.
Detection and Preliminary Genomic Characterization of Poultry-Derived Salmonella enterica from Southern Kazakhstan.
The study identified multidrug-resistant Salmonella enterica isolates from poultry farms in southern Kazakhstan, with universal fluoroquinolone resistance and plasmid-borne AMR genes such as blaTEM-116, tet(A), sul1, ant(3")-Ia, and dfrA14.
Genomic epidemiology of Salmonella Typhimurium and its monophasic variants in Southern China: A spatiotemporal and source attribution analysis.
The study identified blaTEM-1, tet(A), and sul2 as the most prevalent antimicrobial resistance genes in Salmonella Typhimurium isolates from Jiangxi Province, China. Additionally, point mutations in the quinolone resistance-determining region of the gyrA gene were found to be responsible for ciprofloxacin resistance.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
The study identified mcr-1.1-harboring multidrug-resistant E. coli isolates from chicken in the UAE, highlighting the presence of various AMR genes and mutations contributing to resistance against multiple antibiotics, including colistin, beta-lactams, quinolones, and aminoglycosides.
A new filamentous phage cloning vector: fd-tet.
The study describes the creation of a new filamentous phage, fd-tet, which incorporates a segment of transposon Tn10 encoding tetracycline resistance. This phage can be used as a cloning vector to produce large quantities of cloned DNA in single-stranded form.
Inhibitory effects of chloramphenicol isomers and other antibiotics on protein synthesis and respiration in procyclic Trypanosoma brucei brucei.
The study investigated the effects of various antibiotics on protein synthesis and respiration in procyclic Trypanosoma brucei brucei, revealing that D-chloramphenicol, erythromycin, and tetracycline inhibit both cytoplasmic and mitochondrial protein synthesis, likely through their impact on mitochondrial respiration.
High Expression of Plasmid-Encoded Tetracycline Resistance Gene in E. coli Causes a Decrease in Membrane-Bound ATPase Activity
Expression of the plasmid-encoded tetracycline resistance gene (tet) in E. coli leads to reduced membrane-bound ATPase activity, affecting cell growth in minimal media.
A genetic study of a Staphylococus aureus plasmid involving cure and transference
The study demonstrates the transfer and cure of a small plasmid carrying tetracycline resistance in Staphylococcus aureus 1030 (55)TetR strains, highlighting the role of plasmids in antibiotic resistance mechanisms.
The tetracycline resistance determinants of RP1 and Tn1721: nucleotide sequence analysis., Partial characterization of a transposon containing the tet(A) determinant in a clinical isolate of Acinetobacter baumannii., Integron-containing IncU R plasmids pRAS1 and pAr-32 from the fish pathogen Aeromonas salmonicida., The unstable tetracycline resistance gene of Streptomyces lividans 1326 encodes a putative protein with similarities to translational elongation factors and Tet(M) and Tet(O) proteins.
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