Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline efflux MFS transporter Tet(H)
Overview
Identification of a truncated, but functionally active tet(H) tetracycline resistance gene in Pasteurella aerogenes and Pasteurella multocida.
Identification of a truncated, but functionally active tet(H) tetracycline resistance gene in Pasteurella aerogenes and Pasteurella multocida.
Development, validation, and application of PCR primers for detection of tetracycline efflux genes of gram-negative bacteria.
The study developed and validated PCR primers for detecting tetracycline efflux genes in gram-negative bacteria, identifying multiple tet genes in swine feed, feces, and groundwater, highlighting the spread of tetracycline resistance in agricultural environments.
New plasmid-borne antibiotic resistance gene cluster in Pasteurella multocida.
The study identifies a novel plasmid-borne antibiotic resistance gene cluster in Pasteurella multocida, including sul2 for sulfonamide resistance, strA and strB for streptomycin resistance, and tet(H) for tetracycline resistance.
Update on acquired tetracycline resistance genes.
Update on acquired tetracycline resistance genes.
Update on acquired tetracycline resistance genes.
Distribution of Tetracycline Resistance Genes in Actinobacillus pleuropneumoniae Isolates from Spain.
The study identified tet(B), tet(O), tet(H), and tet(L) genes in Actinobacillus pleuropneumoniae isolates from Spain, all of which confer tetracycline resistance through efflux mechanisms.
Monitoring and Source Tracking of Tetracycline Resistance Genes in Lagoons and Groundwater Adjacent to Swine Production Facilities over a 3-Year Period
The study identified and characterized seven tetracycline resistance genes (tet(M), tet(O), tet(Q), tet(W), tet(C), tet(H), and tet(Z)) in lagoons and groundwater near swine production facilities over a 3-year period. These genes were consistently detected in groundwater and lagoon samples, with varying frequencies and concentrations depending on the location and sampling time.
Molecular structure and translocation of a multiple antibiotic resistance region of a Psychrobacter psychrophilus permafrost strain.
Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids.
The study identifies several AMR genes, including bla ROB-1, tet(B), tet(H), tet(O), strA, and sul2, which are responsible for multidrug resistance in Pasteurella multocida. These genes are located on small plasmids and contribute to resistance against beta-lactams, tetracyclines, streptomycin, and sulfamethoxazole.
Long-term exposure to antibiotics has caused accumulation of resistance determinants in the gut microbiota of honeybees.
The study identifies eight tetracycline resistance genes (tetB, tetC, tetD, tetH, tetL, tetY, tetM, and tetW) in the gut microbiota of honeybees, highlighting the accumulation of resistance determinants due to long-term antibiotic exposure in beekeeping practices.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
Susceptibility to tulathromycin in Mannheimia haemolytica isolated from feedlot cattle over a 3-year period.
The study found that tulathromycin resistance in Mannheimia haemolytica from feedlot cattle in western Canada was very low, with only five isolates showing resistance. These isolates were also resistant to other antibiotics such as neomycin, oxytetracycline, tilmicosin, and ampicillin/penicillin. The resistance mechanisms involved the genes bla ROB-1, aphA-1, and tet(H).
Previously Undescribed Plasmids Recovered from Activated Sludge Confer Tetracycline Resistance and Phenotypic Changes to Acinetobacter oleivorans DR1.
The study identifies three previously undescribed tetracycline resistance plasmids (pAST1, pAST2, pAST3) and one previously reported plasmid (pAST4) from activated sludge, which confer tetracycline resistance in Acinetobacter oleivorans DR1.
Plasmid-encoded tetracycline efflux pump protein alters bacterial stress responses and ecological fitness of Acinetobacter oleivorans.
The plasmid-encoded tetracycline efflux pump gene tetH was identified as a key factor in conferring tetracycline resistance and altering bacterial stress responses and ecological fitness in Acinetobacter oleivorans DR1.
Comparative Genomic Analysis of Mannheimia haemolytica from Bovine Sources.
The study identified a bla ROB-1 gene in an integrative conjugative element (ICE) of M. haemolytica, which had a single nucleotide substitution leading to a non-functional gene and sensitivity to ampicillin.
Genomic signatures of Mannheimia haemolytica that associate with the lungs of cattle with respiratory disease, an integrative conjugative element, and antibiotic resistance genes.
The study identifies multiple antibiotic resistance genes in Mannheimia haemolytica, particularly in genotype 2, subtype 2b isolates, which are associated with the lungs of cattle with respiratory disease and contain various combinations of resistance genes.
PCR-Based Analysis of ColE1 Plasmids in Clinical Isolates and Metagenomic Samples Reveals Their Importance as Gene Capture Platforms.
The study identifies ColE1 plasmids as significant platforms for the spread of antibiotic resistance genes, particularly in Enterobacteriaceae and Pasteurellaceae. It characterizes several resistance genes, including blaTEM-116, strA, strB, sul2, qnrB19, and aph(3')-IIa, highlighting their role in conferring resistance to beta-lactams, aminoglycosides, sulfonamides, and fluoroquinolones.
Current Status of the Use of Antibiotics and the Antimicrobial Resistance in the Chilean Salmon Farms.
The study identifies several AMR genes, including floR, tet(A), tet(B), tet(H), tet(l), tet(34), tet(35), aac(6')-Ib-cr, and intI1, associated with resistance to florfenicol, oxytetracycline, quinolones, and kanamycin in Chilean salmon farming environments.
Integrative Conjugative Element ICEHs1 Encodes for Antimicrobial Resistance and Metal Tolerance in Histophilus somni.
The study identifies the integrative conjugative element ICEHs1 in Histophilus somni, which carries the tetracycline resistance gene tet(H), the multidrug efflux pump gene ebrB, and metal tolerance genes mco, czcD, and acr3. The element is capable of horizontal transfer and contributes to increased antimicrobial and metal resistance in H. somni.
Extended antibiotic treatment in salmon farms select multiresistant gut bacteria with a high prevalence of antibiotic resistance genes.
The study identifies several AMR genes, including floR, fexA, and various tetracycline resistance genes (tetA, tetB, tetE, tetH, tetL, tetM, tet34, tet35), associated with resistance to florfenicol and oxytetracycline in gut bacteria from salmon farms. These genes were found in multiple bacterial species, highlighting the widespread nature of AMR in aquatic environments.
Comparative diversity of microbiomes and Resistomes in beef feedlots, downstream environments and urban sewage influent.
The study identified several tetracycline, macrolide, aminoglycoside, beta-lactam, sulfonamide, mercury, and biocide resistance genes in beef feedlots, catch basin water, soil, and urban sewage influent. Tetracycline resistance was predominant in beef production systems, while urban sewage influent showed a diverse resistome with resistance to multiple antimicrobial classes.
Resistome metagenomics from plate to farm: The resistome and microbial composition during food waste feeding and composting on a Vermont poultry farm.
The study identified 50 unique antibiotic resistance genes (ARGs) in food waste, compost, and farm products, with a focus on aminoglycoside, tetracycline, and macrolide resistance. Key ARGs included aph(6)-1d, lmrD, mefA, mel, abeM, abeS, adeF, adeG, adeI, adeJ, adeK, emrD, sul2, tetH, tetM, tetO, tetW, and tetX, which were found in various samples and showed resistance to multiple drug classes.
Antimicrobial Resistance in Members of the Bacterial Bovine Respiratory Disease Complex Isolated from Lung Tissue of Cattle Mortalities Managed with or without the Use of Antimicrobials.
The study identified several AMR genes, including aadA31, bla ROB-1, floR, mph(E), msr(E), and tet(H), in bovine respiratory disease organisms, highlighting the impact of antimicrobial use on AMR development.
Genomic diversity and molecular epidemiology of Pasteurella multocida.
This study identified several antimicrobial resistance genes in Pasteurella multocida, including aminoglycoside, beta-lactam, tetracycline, macrolide, and sulfonamide resistance genes, highlighting the diverse resistance mechanisms present in this pathogen.
First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia.
The study identified the first emergence of resistance to macrolides and tetracycline in Mannheimia haemolytica and Pasteurella multocida isolates from Australian beef feedlots. The resistance mechanisms included the genes msr(E), mph(E), tet(H)-tet(R), and bla ROB-1.
Genome Analysis of Acinetobacter lwoffii Strains Isolated from Permafrost Soils Aged from 15 Thousand to 1.8 Million Years Revealed Their Close Relationships with Present-Day Environmental and Clinical Isolates.
The study identified antibiotic resistance genes such as aadA27, cflA, tet(H), blaOXA-134, cat, macAB, and tolC in Acinetobacter lwoffii strains isolated from permafrost soils. These genes were found to be present in both clinical and environmental strains, suggesting a shared resistance profile.
Prevalence, Risk Factors, and Antimicrobial Resistance Profile of Respiratory Pathogens Isolated From Suckling Beef Calves to Reprocessing at the Feedlot: A Longitudinal Study.
The study characterized antimicrobial resistance profiles of respiratory pathogens in beef calves, identifying several AMR genes associated with resistance to macrolides, aminoglycosides, and other antibiotics.
Evaluating the potential of third generation metagenomic sequencing for the detection of BRD pathogens and genetic determinants of antimicrobial resistance in chronically ill feedlot cattle.
The study identified various antimicrobial resistance genes (ARGs) in metagenomic sequencing data from chronically ill feedlot cattle, including genes conferring resistance to beta-lactams, aminoglycosides, macrolides, phenicols, tetracyclines, and trimethoprim. Notably, tetH was the most frequently detected resistance gene, and several ARGs were found to be associated with integrative and conjugative elements (ICEs).
Proposal of a Method for Harmonized Broth Microdilution Antimicrobial Susceptibility Testing of Avibacterium gallinarum.
The study identified several antimicrobial resistance genes in Avibacterium gallinarum, including bla TEM, dfrA14, sul2, tet(B), and tet(H), which confer resistance to various antibiotics such as penicillin, trimethoprim, sulfamethoxazole, and tetracyclines.
Antimicrobial resistance and associated genetic background of Histophilus somni isolated from clinically affected and healthy cattle.
The study identified several AMR genes in Histophilus somni isolates, including bla ROB - 1, aphA-1, strA, strB, tetH, and tetR, which are associated with resistance to ampicillin, amoxicillin, kanamycin, streptomycin, and oxytetracycline. These genes were found in isolates from respiratory diseases and were linked to increased MICs.
Genetic characteristics, antimicrobial resistance, and prevalence of Arcobacter spp. isolated from various sources in Shenzhen, China.
The study identified several AMR genes in Arcobacter spp., including beta-lactamase genes (blaOXA464, blaOXA491), tetracycline resistance genes (tet(L), tet(H), tet(M)), a macrolide resistance gene (ere(A)), and aminoglycoside resistance genes (APH(3')-IIIa, ant(6)-Ia, SAT-4). Additionally, a mutation in the gyrA gene (C254T) was found to confer fluoroquinolone resistance.
Antimicrobial Susceptibility and Resistance Mechanisms in Mannheimia haemolytica Isolates from Sheep at Slaughter.
The study identified the presence of tetracycline resistance gene tetH, aminoglycoside resistance gene strA, and sulfonamide resistance gene sul2 in M. haemolytica isolates. These genes were often found in plasmid sequences but did not consistently lead to resistance phenotypes.
Pathognomonic features of Pasteurella multocida isolates among various avian species in Sharkia Governorate, Egypt.
The study identified several AMR genes in Pasteurella multocida isolates, including ermX (erythromycin resistance), blaROB-1 (beta-lactam resistance), mcr-1 (colistin resistance), sul1 (sulfonamide resistance), dfrA1 (trimethoprim resistance), and tetH (tetracycline resistance).
Tulathromycin metaphylaxis increases nasopharyngeal isolation of multidrug resistant Mannheimia haemolytica in stocker heifers.
The study found that tulathromycin metaphylaxis increased the isolation of multidrug-resistant (MDR) Mannheimia haemolytica (MH) in stocker heifers. MDR MH isolates were associated with integrative conjugative elements (ICE) carrying antimicrobial resistance genes.
Shotgun Metagenomics-Guided Prediction Reveals the Metal Tolerance and Antibiotic Resistance of Microbes in Poly-Extreme Environments in the Danakil Depression, Afar Region.
The study identified numerous antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in the metagenomes of Lake Afdera and the Assale salt plain in the Danakil Depression. Key ARGs included beta-lactamases (ACC-1, OXA-58, OXA-363, OXA-212, NDM-17, OXA-134, ACT-29, LRA-19), efflux pumps (emrB, abeM, abeS, mgrA, adeJ, MexC, adeL, adeH), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet39, tetX, tetK), and others. MRGs included copper resistance genes (copC, copD), cadmium resistance gene (cadD), mercury resistance gene (merA), chromate resistance genes (chrB, chrA), nickel-cobalt-cadmium resistance genes (nccA, nccB), cobalt-zinc-cadmium resistance gene (czcD), arsenic resistance gene (arsO), lead resistance gene (pbrA), and mercury resistance genes (merB, merR, MIR).
Genomic Insights into the Adaptation and Antibiotic Resistance Mechanisms of Williamsia chitiniclastica
The study identifies several AMR genes in Wohlfahrtiimonas chitiniclastica, including macA, macB, tehB, tet(H), tet(B), ant(2″)-Ia, aac(6′)-Ib, ant(3″)-Ib, bla VEB-1, bla OXA-1, aph(3′)-Ib, sul2, strA, and dfrA1, which confer resistance to various antibiotics such as macrolides, tetracycline, aminoglycosides, beta-lactams, sulfonamides, and trimethoprim.
Recommendation of a standardized broth microdilution method for antimicrobial susceptibility testing of Avibacterium paragallinarum and resistance monitoring.
The study identified several antimicrobial resistance genes in Avibacterium paragallinarum, including aph(6)-Id, aph(3'')-Ib, bla TEM-1B, catA2, sul2, tet(B), tet(H), and mcr-like, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, sulfonamides, tetracyclines, and polymyxins.
Antimicrobial Resistance Genes in Respiratory Bacteria from Weaned Dairy Heifers.
The study identified 26 AMR genes in respiratory bacteria from weaned dairy heifers, with high prevalence of tetracycline, aminoglycoside, sulfonamide, beta-lactam, phenicol, and macrolide resistance genes.
Antimicrobial susceptibility and resistome of Actinobacillus pleuropneumoniae in Taiwan: a next-generation sequencing analysis.
The study identified multiple antimicrobial resistance genes in Actinobacillus pleuropneumoniae isolates from Taiwan, including aminoglycoside, tetracycline, beta-lactam, macrolide, and phenicol resistance genes, highlighting the prevalence of multidrug resistance.
Identification of genetic markers of resistance to macrolide class antibiotics in Mannheimia haemolytica isolates from a Saskatchewan feedlot.
The study identifies several AMR genes and a ribosomal protein mutation associated with macrolide resistance in Mannheimia haemolytica isolates from a Saskatchewan feedlot.
Combatting extensively drug-resistant Salmonella: a global perspective on outbreaks, impacts, and control strategies.
The paper discusses the emergence and global spread of extensively drug-resistant (XDR) Salmonella, highlighting the resistance mechanisms involving genes such as blaCTX-M-15, floR, cat1, cat2, strA, strB, aacC(3), aadA, ant(3")-Ia, aph(3)-IIa, tet(A), tet(B), tet(D), tet(G), tet(H), dfrA10, dhfrXII, sul1, sul2, sul3, mphA, and ermB.
Detection of antimicrobial resistance in Glaesserella parasuis in South China using whole-genome sequencing.
The study identified several AMR genes and mutations in Glaesserella parasuis isolates from South China, including bla ROB–1, catA3, floR, erm(T), tet(B), and tet(H) for resistance to amoxicillin, chloramphenicol, florfenicol, erythromycin, and tetracycline, as well as mutations in gyrA, parC, and parE for enrofloxacin resistance.
Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease.
The study identified several clinically relevant antimicrobial resistance genes (ARGs) in bovine respiratory disease (BRD) pathogens, including estT, floR, mphE, erm(42), msrE, aadA, ANT(2''-Ia), APH(3''-Ib), APH(3'-Ia), APH(6)-Id, sul2, tet(H), ROB-1, and OXA-2. Additionally, mutations in gyrA and parC were found to confer resistance to fluoroquinolones in Mannheimia haemolytica.
Unveiling resistance patterns, kmt1 sequence analyses, virulence traits, and antibiotic resistance genes of multidrug-resistant Pasteurella multocida retrieved from poultry and rabbits.
The study identified bla ROB−1, tet H, and erm X as antibiotic resistance genes in multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Pasteurella multocida isolated from poultry and rabbits.
Genomic epidemiology and antimicrobial resistance of Morganella clinical isolates between 2016 and 2023.
The study identified several AMR genes in Morganella clinical isolates, including tet(B), sul1, catA2, sul2, floR, aadA1, and others, contributing to resistance against various antibiotics.
Antimicrobial Resistance in Pasteurella multocida Isolates from Bovine Mastitis Can Be Associated with Multidrug-Resistance-Mediating Integrative and Conjugative Elements (ICEs).
Integrative and conjugative elements associated with antimicrobial resistance in multidrug resistant Pasteurella multocida isolates from bovine respiratory disease (BRD)-affected animals in Spanish feedlots.
The study identified multiple antimicrobial resistance genes and mutations in multidrug-resistant Pasteurella multocida isolates from bovine respiratory disease-affected animals in Spanish feedlots, highlighting the role of mobile genetic elements in the spread of resistance.
CapSeq for Surveillance in Environmental Samples
The study demonstrates the effectiveness of CapSeq in detecting and genotyping bacterial pathogens and antibiotic resistance genes in bovine respiratory disease (BRD) samples, highlighting the presence of various resistance genes such as bla-TEM, bla-ROB, tetM, tetQ, tetS, tetH, tetX, floR, rrs, and rrl.
Comparative Analysis of Phenotypic and Genotypic Antibiotic Susceptibility of Pasteurella multocida Isolated from Various Host Species in France and Hungary.
The study identified the most prevalent resistance genes in P. multocida as str A, sul 2, and tet H. Mutations in gyr A were associated with fluoroquinolone resistance.
A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.
A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.
Tn5706, a transposon-like element from Pasteurella multocida mediating tetracycline resistance.
The study identified Tn5706, a transposon-like element carrying the tet(H) gene responsible for tetracycline resistance in Pasteurella multocida, which was shown to confer resistance when transferred to Escherichia coli.
Identification of a truncated, but functionally active tet(H) tetracycline resistance gene in Pasteurella aerogenes and Pasteurella multocida., Tn5706, a transposon-like element from Pasteurella multocida mediating tetracycline resistance., A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.
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