Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline efflux MFS transporter Tet(K)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Tet(K) | Card DatabaseReference Gene CatalogReslit | 123 | TETRACYCLINE, tetracycline +3 | Staphylococcus aureus +77 | United States, North America|Latin America|India|Taiwan|Australia|Eastern Europe|Western Europe|South Africa, Switzerland, US West Coast, China, Germany|United Kingdom|Ireland|France|Malta|Abu Dhabi|Hong Kong|Australia|Trinidad & Tobago|United States|Italy|Spain|Portugal|Switzerland|Canada|Middle East|USA|Asia|UK, Ireland, Northwest USA, Denmark|United States|Italy|Germany, Brazil, Nsukka agricultural zone, Nigeria, Italy, Poland, Denmark, Afghanistan, Germany|Egypt|Brazil|Chile|Vietnam|Russia|Belarus|Thailand, Taiwan, USA|France|Portugal|China|Brazil|Germany|Sweden|Italy|Spain|Denmark|Japan|Korea|Europe|Asia|North America, Russia, Sri Lanka|United Kingdom|Australia, Germany, Northern Province|Kigali District, Kuwait, Portugal, GA, USA, Nigeria, Spain, Europe, North America|Europe, Hungary, Ghana, Korea, Europe|Spain|Tunisia|United Kingdom|Denmark|Ireland, Thailand, South Africa, Hawai'i|Hawaiʻi Island, Pakistan, Rwanda, Yunnan, China, Bangladesh|South Africa|Nigeria|Pakistan|Ethiopia|USA|UK, Northern Ghana, Sudan, Europe|United States|Asia, Somalia|Kenya|East Africa, Tunisia, France, Portugal|Spain|Italy|Morocco, Algeria, Global|Guinea|Austria|Vietnam|China|Spain|Canada|Hong Kong|Malaysia|Germany|South Africa|Vancouver|Vienna, Eastern Tanzania, Serbia, Japan, Rio de Janeiro, North America|South America|Europe|Asia|Africa, Shanghai, China, Kenya, Egypt, La Rioja, Spain, Vermont, Tanzania, Spain|Portugal|Germany|UK|Switzerland|Thailand|Italy, North America, Malaysia, Egypt|Kuwait, Southeast Nigeria|Nigeria, Saudi Arabia, East Africa, Sardinia, Italy | 1999, 2004, 2006, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | S67449.1 | AAB28795.1 |
| tet(K) | Card DatabaseResFinder Database | 2 | TETRACYCLINE, DOXYCYCLINE | Staphylococcus aureus | - | 1983 | S67449.1 | AAB28795.1 |
| tetK | Reslit | 174 | tetracycline, doxycycline +2 | Staphylococcus aureus +82 | Europe|North America|Asia, Norway, Germany, Germany|eastern Saxony|southern Brandenburg, Taiwan, Spain, South-West Nigeria|North-East Nigeria, Turkey, Malaysia, United States|Afghanistan, Australia, Nigeria, Iran, Europe, Pakistan, Eastern Cape, South Africa, Taiwan|USA, Kuwait, Hong Kong, South Africa, UK, China, Egypt, London, UK, Udaipur, Italy, Korea, International Space Station, Poland, East London|West London, Global, Hainan, China, Europe|Israel|United Kingdom|Republic of Ireland|Italy, India, Spain|Italy, North West Province, South Africa, Brazil, Serbia, Sardinia, Italy|Italy, Portugal|Spain|Denmark, Portugal, University Hospital Tübingen, Western Uganda, Portugal|Brazil, Kenya, United States, Northern Xinjiang, China, Manhiça District, Southern Mozambique, Northern Algeria|cattle, Thailand|Denmark|Malaysia|China|Australia|United Kingdom|United States|Sweden|Singapore|France|Germany|Gabon|Israel|Japan, Bangladesh, Zambia, Saudi Arabia, Bulgaria, South-eastern Poland, Netherlands, Edo, Nigeria, Northern Pacific Ocean|Norway Sea|Europe, Atlantic salmon, Argentina|United States, Swiss Canton Tessin|various herds|Switzerland, Thuringia, Germany, Colombia, Danakil Depression, Afar Region, Ethiopia, USA, Slovakia, Spain|Northern Spain, Caatinga biome, Scotland, Japan, Uganda, South Korea, Ghana, Nîmes (France)|Québec (Canada), Europe|Africa|North America|South America|Asia|Oceania, Northwestern Transylvania, Romania, China|Hunan Province, Xizang, Northern Italy, Egypt|healthcare facilities 1|healthcare facilities 2|healthcare facility 1|healthcare facility 2, Vietnam, Southern Benin|Benin, Xinjiang, China, Free State Province, South Africa|South Africa, Ankara, Türkiye | 2002, 2003, 2006, 2008, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AF426833|AF426834|AF426835 | - |
| tetk | Reslit | 1 | tetracycline | Staphylococcus aureus | - | 2016 | - | - |
| tet K | Reslit | 6 | tetracycline | Staphylococcus aureus +8 | Algeria, South Africa, Europe|South America, Eastern Cape province, South Africa|South Africa, Thailand, Europe | 2018, 2021, 2022, 2024, 2025 | - | - |
| tet (K) | Reslit | 2 | tetracycline | Salmonella enterica subsp. enterica serovar Enteritidis | Europe|Asia|Belgium|Netherlands|Thailand, Spain | 2018, 2025 | NC_010393|NC_031940|NC_019488 | - |
In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936).
The study characterizes the in vitro and in vivo antibacterial activities of TBG-MINO, a novel glycylcycline, against various tetracycline-resistant strains, including those with tet(A), tet(B), tet(C), tet(D), tet(K), and tet(M) resistance determinants.
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Frequency of disinfectant resistance genes and genetic linkage with beta-lactamase transposon Tn552 among clinical staphylococci.
The study identifies the presence of disinfectant resistance genes qacA/B and beta-lactamase gene blaZ in clinical staphylococci, highlighting their genetic linkage with the transposon Tn552. It also reports the presence of the tetracycline resistance gene tetK in these isolates.
Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus.
The study describes a multiplex PCR assay for detecting nine clinically relevant antibiotic resistance genes in Staphylococcus aureus, including mecA, aacA-aphD, erm(A), erm(C), tetK, tetM, and vat genes, which confer resistance to methicillin, aminoglycosides, macrolides, lincosamides, streptogramins, tetracyclines, and quinupristin-dalfopristin.
Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936).
The study identified several efflux transporter genes, including tet(B), tet(C), tet(K), acrAB, acrEF, and bcr, that influence the susceptibility of Escherichia coli to tigecycline. While tigecycline was effective against strains expressing these efflux pumps, it was found to be a substrate for AcrAB and AcrEF, suggesting potential resistance mechanisms.
Characterization of a Strain of Community-Associated Methicillin-Resistant Staphylococcus aureus Widely Disseminated in the United States
The study characterizes a community-associated methicillin-resistant Staphylococcus aureus strain (USA300-0114) that exhibits resistance to multiple antibiotics, including penicillin, oxacillin, erythromycin, tetracycline, and fluoroquinolones. Key resistance genes identified include blaZ, msrA, mecA, tet(K), and ermC, along with the Panton-Valentine leucocidin toxin genes lukF-PV and lukS-PV.
Diagnostic PCR analysis of the occurrence of methicillin and tetracycline resistance genes among Staphylococcus aureus isolates from phase 3 clinical trials of tigecycline for complicated skin and skin structure infections.
The study identified the presence of the mecA gene, which confers methicillin resistance, and tetracycline resistance genes tet(M) and tet(K) in Staphylococcus aureus isolates from phase 3 clinical trials of tigecycline.
Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus.
Microarray-based characterisation of a Panton-Valentine leukocidin-positive community-acquired strain of methicillin-resistant Staphylococcus aureus
The study identified the presence of the tetK and far1 genes in a Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus strain, which conferred resistance to tetracycline and fusidic acid respectively. A novel plasmid (pUB102) carrying these genes was also characterized.
Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
The study identified a multidrug-resistant PVL+ CA-MRSA ST59 strain in Taiwan with a novel SCC mec type VII, carrying resistance genes such as tetK, cat, aadE, aph(3')-IIIa, ermB, blaZ, and cadDX.
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
The study characterizes new SCCmec elements and mutations in topoisomerase genes associated with fluoroquinolone and methicillin resistance in Staphylococcus pseudintermedius.
Efflux-mediated drug resistance in bacteria: an update.
The paper provides an updated overview of drug efflux pumps in bacteria, focusing on their structure, mechanisms, and roles in multidrug resistance. It highlights the importance of RND, MFS, MATE, SMR, and ABC transporters in efflux-mediated resistance.
Characterization of methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococcus spp. isolated from US West Coast public marine beaches.
The study identified methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococcus (MRCoNS) isolates carrying resistance genes erm(A), tet(M), and tet(K) from marine environments along the US West Coast.
Skin lesion caused by ST398 and ST1 MRSA, Spain.
The study identifies multiple antimicrobial resistance genes and mutations in MRSA strains causing a skin lesion in a Spanish patient, including mecA, tetK, tetL, tetM, ermA, ermB, ermC, msrA, aph(2')-acc(6'), ant(4')-Ia, aph(3')-III, and dfrK, along with quinolone resistance mutations in grlA and gyrA.
Antibiotic resistance characteristics of environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river.
The study identified multiple tetracycline resistance genes (tet(A), tet(W), tet(C), tet(J), tet(L), tet(D), tet(Y), and tet(K)) in environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river, highlighting the widespread dissemination of these genes in aquatic environments exposed to high levels of antibiotic residues.
Whole genome analysis of a livestock-associated methicillin-resistant Staphylococcus aureus ST398 isolate from a case of human endocarditis.
The study identifies tetracycline resistance genes tet(M) and tet(K), as well as the methicillin resistance gene mecA in the ST398 MRSA isolate S0385, highlighting its multidrug resistance profile.
Empyema caused by MRSA ST398 with atypical resistance profile, Spain.
The study reports MRSA ST398 isolates with resistance to beta-lactams, tetracycline, clindamycin, ciprofloxacin, and levofloxacin, carrying mecA, tetK, tetM, and vga(A) genes, along with gyrA(S84L) and parC(S80F) mutations.
Massively parallel pathogen identification using high-density microarrays.
The study demonstrates the use of a high-density microarray for the identification of pathogens and the detection of antibiotic resistance genes, including blaZ, ermC, mph, and tetK, in clinical samples.
A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus.
The study characterizes various methicillin-resistant Staphylococcus aureus (MRSA) clones, highlighting their antimicrobial resistance and virulence-associated markers, with a focus on SCC mec types and PVL status.
Antibiotic resistance and molecular epidemiology of Staphylococcus aureus in Nigeria.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from Nigeria, including aacA-aphD, ermA, mecA, tetK, and tetM, which confer resistance to gentamicin, erythromycin, oxacillin, and tetracycline. High levels of resistance to tetracycline and trimethoprim/sulfamethoxazole were observed.
The increase of methicillin-resistant Staphylococcus aureus (MRSA) and the presence of an unusual sequence type ST49 in slaughter pigs in Switzerland.
The study identifies the presence of methicillin-resistant Staphylococcus aureus (MRSA) in slaughter pigs in Switzerland, highlighting the emergence of the unusual sequence type ST49. It reports various AMR genes such as mecA, blaZ, tet(M), tet(K), erm(A), erm(C), ant(9)-Ia, str, dfr(G), and vga(A)v, which confer resistance to β-lactams, tetracycline, macrolides, lincosamides, streptogramins B, spectinomycin, streptomycin, trimethoprim, and tiamulin.
Genotypes, exotoxin gene content, and antimicrobial resistance of Staphylococcus aureus strains recovered from foods and food handlers.
The study identified various AMR genes in S. aureus strains from foods and food handlers, including blaZ, mupA, ermC, msrB, msrA, aacA, aphD, aadD, and tetK, which confer resistance to beta-lactams, mupirocin, erythromycin, clindamycin, aminoglycosides, and tetracycline.
Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic.
The study characterizes several tetracycline resistance genes, including tet(M), tet(K), tet(B), tet(A), and tet(X), demonstrating their roles in conferring resistance to tetracycline and related antibiotics.
Antibiotic resistance genes & susceptibility patterns in staphylococci.
The study identified several antibiotic resistance genes in staphylococcal isolates, including mecA for methicillin resistance, aac(6')/aph(2"), aph(3')-IIIa, and ant(4')-Ia for gentamicin resistance, ermA, ermB, ermC, and msrA for erythromycin resistance, tetK and tetM for tetracycline resistance, and blaZ for penicillin resistance.
ermA, ermC , tetM and tetK are essential for erythromycin and tetracycline resistance among methicillin-resistant Staphylococcus aureus strains isolated from a tertiary hospital in Malaysia.
The study identified ermA, ermC, tetM, and tetK as essential genes for erythromycin and tetracycline resistance in MRSA strains from a Malaysian hospital.
DNA microarray profiling of a diverse collection of nosocomial methicillin-resistant staphylococcus aureus isolates assigns the majority to the correct sequence type and staphylococcal cassette chromosome mec (SCCmec) type and results in the subsequent identification and characterization of novel SCCmec-SCCM1 composite islands.
The study identifies and characterizes novel SCCmec-SCCM1 composite islands in MRSA isolates, highlighting the presence of various AMR genes such as blaZ, erm(A), aadD, qacA, qacC, merA, merB, fosB, sdrM, aacA-aphD, far1 (fusB), Q6GD50 (fusC), and cat-pC194 (pMC524).
Comparison of Multi-Drug Resistant Environmental Methicillin-Resistant Staphylococcus aureus Isolated from Recreational Beaches and High Touch Surfaces in Built Environments.
The study identified multiple antibiotic resistance genes in environmental MRSA isolates, including aadD, erm(A), erm(C), msr(A), tet(K), and tet(M), which confer resistance to kanamycin, erythromycin, clindamycin, and tetracycline. These genes were found in a high proportion of the isolates, indicating that environmental MRSA can serve as reservoirs for antibiotic resistance genes.
Pharmacodynamics of doxycycline and tetracycline against Staphylococcus pseudintermedius: proposal of canine-specific breakpoints for doxycycline.
The study identifies tetracycline resistance genes tet(M), tet(K), and tet(O) in Staphylococcus pseudintermedius isolates and proposes canine-specific breakpoints for doxycycline susceptibility testing.
Staphylococcus aureus colonization of healthy military service members in the United States and Afghanistan.
The study identified several AMR genes in MRSA and MSSA isolates, including ermC, tetK, tetM, blaZ, msrA, and ermA, which confer resistance to clindamycin, tetracycline, penicillin, and erythromycin. These findings highlight the genetic basis of antimicrobial resistance in S. aureus isolates from military personnel in the US and Afghanistan.
Adaptive change inferred from genomic population analysis of the ST93 epidemic clone of community-associated methicillin-resistant Staphylococcus aureus.
The study identifies several AMR genes including ermC, dfhR, tetK, and qacC in the ST93 clone of S. aureus, which confer resistance to erythromycin, trimethoprim, tetracycline, and quaternary ammonium compounds/beta-lactams respectively. Mutations in the agr locus were found to affect virulence gene expression.
Title of the Paper
The study characterizes antibiotic-resistant Staphylococcus aureus strains (EryR, KanR, TetR) and demonstrates that sub-curative antibiotic doses can selectively expand resistant bacterial populations during infection.
Whole genome analysis of a community-associated methicillin-resistant Staphylococcus aureus ST59 isolate from a case of human sepsis and severe pneumonia in China.
The study identified the tetracycline resistance gene tet(K) in the ST59 CA-MRSA isolate SA268, which was found to be susceptible to tetracycline despite carrying this gene.
Diversity of antibiotic resistance genes and staphylococcal cassette chromosome mec elements in faecal isolates of coagulase-negative staphylococci from Nigeria.
The study identified several antibiotic resistance genes, including aac(6')-aph(2"), ermC, msrA, tetK, tetM, and mecA, in faecal isolates of coagulase-negative staphylococci from Nigeria. These genes were associated with resistance to gentamicin, erythromycin, and tetracycline, as well as methicillin resistance.
Characterization of methicillin-resistant coagulase-negative staphylococci in milk from cows with mastitis in Brazil.
The study identified methicillin-resistant coagulase-negative staphylococci (MRCoNS) in milk from cows with mastitis in Brazil, highlighting the presence of various antimicrobial resistance genes including mecA, tet(K), str, ant(4')-I, aac(6')-aph(2"), lnu(B), lsa(E), and a modified erm(C) gene with an 89-bp deletion.
Rapid Diagnostic Approaches for Antimicrobial Resistance
The paper discusses various rapid antimicrobial resistance testing methods, including molecular techniques like qPCR, DNA microarrays, Luminex xMAP, and next-generation sequencing (NGS), highlighting their roles in detecting resistance genes such as blaCTX-M, blaTEM, blaSHV, blaKPC, blaNDM, blaOXA-48, blaVIM, blaIMP, mecA, mecC, vanA, vanB, aacA-aphD, tetK, tetM, ermA, ermC, vatA, vatB, and vatC in different bacterial species.
Meticillin-resistant Staphylococcus aureus isolated from Iranian hospitals: virulence factors and antibiotic resistance properties.
The study identified several AMR genes in meticillin-resistant Staphylococcus aureus (MRSA) isolates from Iranian hospitals, including mecA, tetK, ermA, ermC, aacA-D, linA, msrA, vatA, vatC, and vatB. Additionally, the Panton-Valentine leukocidin (PVL) gene was found in 40.9% of the isolates.
Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis.
The study identifies several AMR genes, including aac(6')-aph(2")-Ia, vanA, vanB, tetM, ermB, aph(3')-IIIa, and sat4, which are associated with resistance to aminoglycosides, glycopeptides, tetracyclines, macrolides, lincosamides, streptogramin B, and streptothricin in Enterococcus faecium and Enterococcus faecalis.
Characterization of mannitol-fermenting methicillin-resistant staphylococci isolated from pigs in Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant staphylococci isolated from pigs in Nigeria, including mecA, blaZ, erm(C), erm(B), str, tet(K), tet(M), tet(L), dfrG, dfrK, aacA/aphD, aphA3, cat pC221, and cat pC223. Additionally, a Ser84Leu mutation in the gyrA gene was found to confer ciprofloxacin resistance.
Nasal Carriage of Staphylococcus aureus : Frequency and Antibiotic Resistance in Healthy Ruminants.
The study identified the presence of antibiotic resistance genes blaZ, mecA, tetK, and tetM in Staphylococcus aureus isolates from healthy ruminants, highlighting the potential reservoir of antimicrobial-resistant S. aureus in nasal carriage.
A Livestock-Associated, Multidrug-Resistant, Methicillin-Resistant Staphylococcus aureus Clonal Complex 97 Lineage Spreading in Dairy Cattle and Pigs in Italy.
The study identifies multiple AMR genes in CC97 MRSA isolates from Italian dairy cattle and pigs, including erm(B), erm(C), vga(A), tet(K), tet(M), blaZ, and aacA-aphD, which confer resistance to various antibiotics such as erythromycin, clindamycin, tiamulin, tetracycline, penicillin, and aminoglycosides.
Molecular detection of antimicrobial resistance in local isolates of Staphylococcus epidermidis from urinary tract infections in Faisalabad region of Pakistan.
The study identified multiple antimicrobial resistance genes in Staphylococcus epidermidis isolates from urinary tract infections in Pakistan, including tetM, tetK, aac(6')/aph(2"), aacA-aphD, ermA, blaZ, mecA, MeccA, and blaTEM-1, indicating widespread multidrug resistance.
Identification and antimicrobial resistance prevalence of pathogenic Escherichia coli strains from treated wastewater effluents in Eastern Cape, South Africa.
The study identified several AMR genes in E. coli isolates from wastewater effluents, including strA, aadA, catI, cmlA1, blaTEM, and various tetracycline resistance genes (tetA, tetB, tetC, tetD, tetK, tetM). These genes conferred resistance to multiple antibiotics such as streptomycin, gentamicin, chloramphenicol, ampicillin, and tetracycline.
Prevalence of plasmid-mediated multidrug resistance determinants in fluoroquinolone-resistant bacteria isolated from sewage and surface water.
The study identified several plasmid-mediated resistance genes in fluoroquinolone-resistant bacteria, including aac(6')-Ib-cr, qnrS, qnrD, oqx A, blaTEM, blaOXA, blaCTX-M, blaSHV, tet(A), tet(K), tet(L), and tet(S). These genes were found to confer resistance to fluoroquinolones, beta-lactams, and tetracyclines.
Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline.
The study shows that the copresence of tet(K) and tet(M) in LA-MRSA CC398 enhances fitness during exposure to sublethal tetracycline concentrations, with tet(K) providing an additional fitness benefit.
Action of cholecalciferol and alpha-tocopherol on Staphylococcus aureus efflux pumps.
Cholecalciferol and alpha-tocopherol were found to inhibit efflux pumps in Staphylococcus aureus strains, reducing the MIC of antibiotics. Specifically, cholecalciferol showed significant modulation of tetracycline activity against the IS-58 strain.
Identification of source and sink populations for the emergence and global spread of the East-Asia clone of community-associated MRSA.
The study identifies distinct antibiotic resistance gene profiles in Staphylococcus aureus ST59 isolates from the USA and East Asia, with the East Asia clade exhibiting higher resistance to beta-lactams, chloramphenicol, tetracyclines, and macrolides.
Lack of doxycycline antimalarial prophylaxis impact on Staphylococcus aureus tetracycline resistance.
The study found that tetracycline resistance in Staphylococcus aureus isolates from wounded military personnel was associated with the presence of tet(M) and tet(K) genes, but there was no significant association between doxycycline exposure and tetracycline resistance.
Shifts in the Clonal Distribution of Methicillin-Resistant Staphylococcus aureus in Kuwait Hospitals: 1992-2010.
The study identified various AMR genes in MRSA isolates from Kuwait hospitals, including aphA3, aacA-aphD, ermA, ermC, mupA, tetK, tetM, fusC, far1, msrA, mphC, sat, qacA, qacC, merA, merB, dfrS1, aadD, fosB, cat, sdrM, icaA, icaC, and icaD, which conferred resistance to multiple antibiotics.
Variety of Antimicrobial Resistances and Virulence Factors in Staphylococcus aureus Isolates from Meat Products Legally and Illegally Introduced to Germany.
The study identified multiple antimicrobial resistance genes and mutations in Staphylococcus aureus isolates from meat products, including resistance to β-lactams, macrolides, aminoglycosides, tetracyclines, and others.
Characterization of Methicillin-Resistant Staphylococcus aureus Isolated from Healthy Turkeys and Broilers Using DNA Microarrays.
The study identified several AMR genes in MRSA isolates from healthy turkeys and broilers, including ermA, ermB, ermC, tetK, tetM, lnuA, mphC, vgaA, aadD, aphA3, blaZ, blaI, blaR, and mecA. These genes conferred resistance to various antibiotics such as erythromycin, clindamycin, tetracycline, lincomycin, macrolides, streptogramins, tobramycin, neomycin, kanamycin, and beta-lactam antibiotics.
mecA-related structure in methicillin-resistant coagulase-negative staphylococci from street food in Taiwan.
The study identified mecA and mecA Ss genes in methicillin-resistant coagulase-negative staphylococci (MRCoNS) from street food in Taiwan, along with several other resistance genes such as ermA, ermC, tet(M), tet(K), tet(O), and aac(6')-Ie-aph(2'')-Ia, which confer resistance to oxacillin, erythromycin, tetracycline, and gentamicin.
Toward a Metagenomic Understanding on the Bacterial Composition and Resistome in Hong Kong Banknotes.
The study identified a diverse range of antibiotic resistance genes (ARGs) on Hong Kong banknotes, including tetracycline, chloramphenicol, beta-lactam, aminoglycoside, glycopeptide, and fluoroquinolone resistance genes. These genes were found to be more abundant on banknotes compared to other environmental samples, highlighting the potential role of banknotes in the dissemination of antibiotic resistance.
Genetic characterisation of antimicrobial resistance and virulence genes in Staphylococcus aureus isolated from commercial broiler chickens in the Durban metropolitan area, South Africa.
The study identified the presence of antimicrobial resistance genes mecA, BlaZ, and tetK in Staphylococcus aureus isolates from broiler chickens, indicating resistance to methicillin, penicillin, and tetracycline, respectively.
Transmission of highly virulent community-associated MRSA ST93 and livestock-associated MRSA ST398 between humans and pigs in Australia.
The study identified the presence of CA-MRSA ST93-IV and LA-MRSA ST398-V in Australian pigs, farm workers, and the environment. It also reported the first linezolid-resistant MRSA isolate in Australia. Resistance mechanisms included genes such as blaZ, ermC, fexA, tetK, tetL, vgaA, lnuB, aadD, aadE, and cfr.
Environmental surveillance identifies multiple introductions of MRSA CC398 in an Equine Veterinary Hospital in the UK, 2011-2016.
The study identified multiple introductions of MRSA CC398 in an equine veterinary hospital, with the predominant strain being CC398-IVa-t011. The isolates exhibited resistance to gentamicin (aacA-aphD), tetracycline (tetM and tetK), and other antibiotics. The study highlights the importance of environmental surveillance and infection control measures to prevent MRSA transmission.
Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale.
The study identified multiple antimicrobial resistance genes in Enterococcus hirae R17, including genes conferring resistance to beta-lactam antibiotics, lincosamides, streptogramins, pleuromutilins, polymyxins, tetracyclines, and others. Notably, the strain exhibited resistance to bacitracin, ciprofloxacin, daptomycin, erythromycin, and tetracycline.
Phenotypic and genotypic characterization of antibiotic resistance of methicillin-resistant Staphylococcus aureus isolated from hospital food.
The study identified tetK, ermA, msrA, and aacA-D as the most common antibiotic resistance genes in MRSA strains isolated from hospital food samples, highlighting the potential public health threat posed by multidrug-resistant MRSA.
Biofilm-Forming Clinical Staphylococcus Isolates Harbor Horizontal Transfer and Antibiotic Resistance Genes.
The study identified several antibiotic resistance genes, including aac6-aph2a, ermC, tetK, and vanB, along with horizontal transfer genes such as pre pSK41, nes pSK41, traE, traG, traK, traL, traM, and pre pT181, in biofilm-forming Staphylococcus isolates.
Detection of tetracycline resistance genes, aminoglycoside modifying enzymes, and coagulase gene typing of clinical isolates of Staphylococcus aureus in the Southwest of Iran.
The study identified aac(6')-Ie-aph(2"), aph(3')-IIIa, ant(4')-Ia, tetK, and tetM as the primary genes responsible for aminoglycoside and tetracycline resistance in Staphylococcus aureus isolates from the Southwest of Iran.
Polymerase chain reaction detection of genes responsible for multiple antibiotic resistance Staphylococcus aureus isolated from food of animal origin in Egypt.
The study identified several antibiotic resistance genes in multiple drug-resistant Staphylococcus aureus isolates from food of animal origin in Egypt, including blaZ, tetK, ermB, msrA, ermC, and aac(6')-aph(2").
Antimicrobial Resistance in Streptococcus spp.
The paper discusses the prevalence and mechanisms of antimicrobial resistance in Streptococcus species, particularly focusing on macrolide, lincosamide, and tetracycline resistance. Key genes identified include erm(B), erm(A), lnuB, lnuD, mefA, mefE, msr, tet(B), tet(K), tet(L), tet(M), tet(O), and tet(S).
Whole Genome Sequence and Comparative Genomics Analysis of Multi-drug Resistant Environmental Staphylococcus epidermidis ST59.
The study identifies several antibiotic resistance genes in the multidrug-resistant S. epidermidis strain G6_2, including aac(6')-aph(2"), blaZ, mecA, fosB, mphC, msrA, tetK, and qacC, which confer resistance to various antibiotics. Additionally, point mutations in ileS and fusA are associated with resistance to mupirocin and fusidic acid.
Evaluation of multiplex polymerase chain reaction as an alternative to conventional antibiotic sensitivity test.
The study evaluated the use of multiplex PCR as an alternative to conventional antibiotic sensitivity tests, demonstrating high correlation between phenotypic and genotypic resistance for methicillin and aminoglycosides, and moderate correlation for tetracycline.
Clonal Lineage Diversity, Antibiotic Resistance, and Virulence Determinants Among Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Isolated from Nurses at a Teaching Hospital in Ilam, Iran: Successful Nares Decolonization by Mupirocin.
The study identified several AMR genes in S. aureus isolates from nurses, including ermC, msrA, tetK, aac(6')-Ie/aph(2')-Ia, aph(3')-IIIa, and ant(4')-Ia, which conferred resistance to erythromycin, clindamycin, tetracycline, and gentamicin.
The draft genomes and investigation of serotype distribution, antimicrobial resistance of group B Streptococcus strains isolated from urine in Suzhou, China.
The study identified several AMR genes in GBS isolates from urine in Suzhou, including tetM, ermB, mefE, lnuB, and others, associated with resistance to tetracycline, erythromycin, clindamycin, and fluoroquinolones.
Antibiotic resistance gene dynamics in the gut microbiota following amoxicillin-clavulanic acid treatment
The study identified several AMR genes, including aminoglycoside resistance genes (ksgA, strA, strB), beta-lactam resistance genes (blaCARB-4, blaCMY-1, blaCMY-2, blaCTX-M-1, blaCTX-M-12, blaDHA-1, blaOXA-1, blaSHV-1, blaSHV-37, blaSHV-3, blaTEM-1A, blaTEM-1B), and tetracycline resistance genes (tetA, tetB, tetC, tetK, tetL), that were enriched in the gut microbiota of healthy adults following amoxicillin-clavulanic acid treatment.
Emerging of antimicrobial resistance in staphylococci isolated from clinical and food samples in Algeria.
The study identified several AMR genes in staphylococci from clinical and food samples in Algeria, including blaZ, mecA, tetM, tetK, aacA-aphD, and ermC. These genes conferred resistance to penicillin, methicillin, tetracycline, gentamicin, and erythromycin.
Occurrence and characterization of methicillin-resistant Staphylococcus pseudintermedius in successive parturitions of bitches and their puppies in two kennels in Italy.
The study identified multiple methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains in two Italian kennels, highlighting the presence of various resistance mechanisms including beta-lactam, aminoglycoside, macrolide, tetracycline, and chloramphenicol resistance genes.
Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris.
Sarecycline shows reduced activity against aerobic enteric Gram-negative bacteria and anaerobes compared to doxycycline and minocycline. It exhibits low spontaneous mutation frequencies against C. acnes, S. aureus, and S. epidermidis. Resistance mechanisms in S. aureus include tet(K), tet(M), and tet(38).
Distribution of Transferable Antibiotic Resistance Genes in Laboratory-Reared Edible Mealworms (Tenebrio molitor L.).
The study identified tetracycline resistance genes (tet(M), tet(K), tet(S)), the MLS B resistance gene erm(B), and the aac-aph gene in laboratory-reared mealworms, indicating the presence of transferable antibiotic resistance genes in edible insects.
Characterization of Erythromycin and Tetracycline Resistance in Lactobacillus fermentum Strains.
The study identified erythromycin resistance genes erm(B) and erm(C) and tetracycline resistance genes tet(K) and tet(M) in Lactobacillus fermentum strains. None of the strains were able to transfer these resistance genes to other bacteria via conjugation.
Investigation of the Dominant Microbiota in Ready-to-Eat Grasshoppers and Mealworms and Quantification of Carbapenem Resistance Genes by qPCR.
The study quantified the presence of carbapenem resistance genes (bla OXA-48, bla NDM-1, and bla VIM) in ready-to-eat mealworms and grasshoppers from various countries, revealing varying frequencies of these genes in different samples.
Transfer of a mobile Staphylococcus saprophyticus plasmid isolated from fermented seafood that confers tetracycline resistance.
The study identifies a tetracycline resistance plasmid, pSSTET1, carrying the tetK gene in Staphylococcus saprophyticus isolated from fermented seafood. The plasmid was transferable to other Staphylococcus species and Enterococcus faecalis, maintaining tetracycline resistance.
Nasal Resistome Development in Infants With Cystic Fibrosis in the First Year of Life.
The study identified various antimicrobial resistance genes in the nasal microbiome of infants with cystic fibrosis, including beta-lactamases, chloramphenicol efflux pumps, tetracycline resistance proteins, and enzymes involved in folic acid synthesis inhibition.
Biofilm Forming Antibiotic Resistant Gram-Positive Pathogens Isolated From Surfaces on the International Space Station.
The study identified several AMR genes including ermC, tetK, aac6-aph2a, aph(2)-ic, aadD, aph3-III, and ermB in Gram-positive pathogens isolated from the International Space Station. These genes conferred resistance to erythromycin, tetracycline, gentamicin, kanamycin, and other antibiotics.
Genomic and Epidemiological Evidence of a Dominant Panton-Valentine Leucocidin-Positive Methicillin Resistant Staphylococcus aureus Lineage in Sri Lanka and Presence Among Isolates From the United Kingdom and Australia.
The study identified a dominant PVL-positive ST5-MRSA-IVc clone in Sri Lanka, which was also found in the UK and Australia. The clone exhibited resistance to methicillin, erythromycin, tetracycline, gentamicin, and streptothricin.
Emergence of multidrug resistance and extensive drug resistance among enterococcal clinical isolates in Egypt.
The study identified several AMR genes in enterococcal isolates, including aac(6')-Ie-aph(2'')-Ia, ant(6')-Ia, ermB, msrA/B, tetK, tetL, tetM, vanB, vanC1, and optrA, which confer resistance to various antibiotics such as gentamicin, streptomycin, macrolides, lincosamides, tetracyclines, vancomycin, and linezolid.
Occurrence and Characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Quarter Milk Samples From Dairy Cows in Germany.
This study identified 10 LA-MRSA isolates from dairy cows in Germany, all belonging to clonal complex CC398. These isolates exhibited resistance to methicillin, tetracycline, and macrolides/lincosamides, with the presence of mecA, blaZ, tet(K), tet(M), erm(A), and spc genes.
Detection of Antibiotic Resistance and Classical Enterotoxin Genes in Coagulase-negative Staphylococci Isolated from Poultry in Poland.
The study identified several AMR genes in coagulase-negative Staphylococcus (CNS) isolates from poultry in Poland, including blaZ, mecA, tetK, tetL, ermA, ermB, aac(6')-Ie-aph(2'')-Ia, msrA/B, and cfr. These genes conferred resistance to various antibiotics such as beta-lactams, methicillin, tetracyclines, macrolides, lincosamides, streptogramin B, aminoglycosides, phenicols, oxazolidinones, pleuromutilins, and streptogramin A.
Whole genome sequencing revealed new molecular characteristics in multidrug resistant staphylococci recovered from high frequency touched surfaces in London.
The study identified several AMR genes in multidrug-resistant staphylococci from high-frequency touched surfaces in London, including blaZ, qacA/B, dfrC, norA, ant(4')-Ib, AAC(6')-Ie-APH(2")-Ia, fusB, msrA, ermC, mphC, tetK, mupA, cat, dfrG, lnuA, fusC, aph3-IIIa, sat4A, vgaA, and others. These genes conferred resistance to various antibiotics such as penicillin, fusidic acid, mupirocin, tetracycline, erythromycin, and chloramphenicol.
Characteristics of methicillin-resistant Staphylococcus aureus from broiler farms in Germany are rather lineage- than source-specific.
The study identified multiple AMR genes in MRSA isolates from German broiler farms, including tet(K), tet(L), tet(M), erm(B), vga(A), dfrK, spc, and cat(pC221), which confer resistance to tetracycline, MLS B antibiotics, tiamulin, trimethoprim, spectinomycin, and chloramphenicol, respectively.
Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990-2017.
The study characterizes the antimicrobial resistance profiles of Staphylococcus aureus clinical isolates in Malaysia, highlighting the presence of mecA gene conferring beta-lactam resistance and erm gene contributing to MLSB resistance.
Antimicrobial Resistance Mechanisms in Antibiotic-Producing Bacteria and Pathogens
The paper discusses various antimicrobial resistance mechanisms in antibiotic-producing bacteria and pathogens, focusing on genes and mutations that confer resistance to different classes of antibiotics, including beta-lactams, aminoglycosides, tetracyclines, chloramphenicol, macrolides, and others.
Phylogenomic Analysis Reveals the Evolutionary Route of Resistant Genes in Staphylococcus aureus.
The study identifies several AMR genes, including blaZ, kmA, tetK, and ble, which are laterally transferred from non-Staphylococcus species and contribute to antibiotic resistance in S. aureus.
Microbe-Derived Indole Metabolite Demonstrates Potent Multidrug Efflux Pump Inhibition in Staphylococcus aureus.
The study identifies RP2, a microbial-derived indole metabolite, as a potent efflux pump inhibitor targeting NorA, TetK, and MsrA in Staphylococcus aureus, enhancing the efficacy of antibiotics by reducing their minimum inhibitory concentrations and preventing the emergence of resistant mutants.
Molecular characteristics and virulence gene profiles of Staphylococcus aureus isolates in Hainan, China.
The study identified ermC, tetK, and tetM as the primary genes responsible for erythromycin and tetracycline resistance in Staphylococcus aureus isolates from Hainan, China.
International travel as source of a hospital outbreak with an unusual meticillin-resistant Staphylococcus aureus clonal complex 398, Denmark, 2016.
The study identifies the PVL-positive human variant of MRSA CC398 as the cause of an outbreak in a Danish maternity unit, highlighting the role of international travelers in introducing such strains into healthcare settings.
Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure.
The study identifies silenced antibiotic resistance genes in Staphylococcus aureus, highlighting the prevalence of transient antibiotic resistance due to mutations that inactivate resistance genes, leading to apparent susceptibility but potential re-emergence of resistance.
Metagenomic identification of severe pneumonia pathogens in mechanically-ventilated patients: a feasibility and clinical validity study.
The study identified several AMR genes using Nanopore sequencing, including mecA, blaTEM-4, blaTEM-112, blaTEM-157, blaACT-5, oqxB, tetC, ermA, erm (33), tet38, ant(4′)-lb, tetK, tetQ, sul1, dfrA, acrF, parE, mfd, mphA, aadA5, vgaC, blaACT-5, blaACT-14, mefA, mel, tetX, tetM, isaC, and aadA5, which conferred resistance to various antibiotics such as methicillin, ticarcillin, ceftazidime, erythromycin, clindamycin, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and levofloxacin.
Carprofen-induced depletion of proton motive force reverses TetK-mediated doxycycline resistance in methicillin-resistant Staphylococcus pseudintermedius.
The study shows that carprofen (CPF) induces proton motive force (PMF) depletion, reversing TetK-mediated doxycycline (DOX) resistance in methicillin-resistant Staphylococcus pseudintermedius (MRSP).
Methicillin-Resistant Staphylococcus aureus Strains in Swiss Pigs and Their Relation to Isolates from Farmers and Veterinarians.
The study identifies several AMR genes in MRSA strains from Swiss pigs, including aac(6')-aph(2"), dfrG, erm(A), erm(C), spc, str, tet(K), tet(M), and vga(E). These genes confer resistance to various antibiotics such as gentamicin, kanamycin, tobramycin, trimethoprim, erythromycin, clindamycin, lincomycin, streptogramin B, streptomycin, tetracycline, streptogramin A, pleuromutilin, and lincomycin.
Characterization of Antibiotic and Biocide Resistance Genes and Virulence Factors of Staphylococcus Species Associated with Bovine Mastitis in Rwanda.
The study identified several antibiotic and biocide resistance genes in Staphylococcus species associated with bovine mastitis in Rwanda, including blaZ, tet(K), erm(C), vga(A), sal(A), lnu(A), msr(A), dfrA, dfrD, dfrG, smr, qacAB, cadD, copB, and arsA. These genes conferred resistance to various antibiotics such as penicillin, tetracycline, erythromycin, clindamycin, trimethoprim, and biocides like quaternary ammonium compounds.
Antibiotic Susceptibility, Virulence Pattern, and Typing of Staphylococcus aureus Strains Isolated From Variety of Infections in India.
The study identified various AMR genes in S. aureus isolates, including mecA, pvl, czrC, qacA/B, aac(6')/aph(2), aph(3'-III), msrA, ermA, ermC, mphC, tetK, tetL, tetM, cat::pC221, cat::pC223, cat::pC194, dfrA, dfrB, and dfrG, which confer resistance to multiple antibiotics such as oxacillin, chloramphenicol, gentamicin, erythromycin, clindamycin, tetracycline, and trimethoprim.
Antimicrobial Resistance and Virulence Gene Profiles of Methicillin-Resistant and -Susceptible Staphylococcus aureus From Food Products in Denmark.
The study identified several antimicrobial resistance genes, including blaZ, tet(K), tet(L), tet(M), and various erm genes, in Staphylococcus aureus isolates from food products in Denmark. Additionally, the tst gene was detected in CC398 and CC45 isolates, indicating the presence of toxic shock syndrome toxin.
Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Patients Admitted to Kuwait Hospitals in 2016-2017.
The study identified LA-MRSA isolates belonging to CC96, CC97, and CC398, with CC97 being the dominant clone. Resistance genes such as erm(A), erm(C), msr(A), aacA-aphD, fusC, tet(K), cat, and dfrS1 were detected, indicating multidrug resistance.
Genotypic and Phenotypic-Based Assessment of Antibiotic Resistance and Profile of Staphylococcal Cassette Chromosome mec in the Methicillin-Resistant Staphylococcus aureus Recovered from Raw Milk.
The study identified several AMR genes in MRSA isolates from raw milk, including blaZ, tetK, dfrA1, aacA-D, ermA, and gyrA, which confer resistance to various antibiotics such as penicillin, tetracycline, trimethoprim-sulfamethoxazole, gentamicin, erythromycin, and fluoroquinolones.
Emergence of Methicillin-Resistant Staphylococcus aureus Belonging to Clonal Complex 15 (CC15-MRSA) in Kuwait Hospitals.
The study identified CC15-MRSA-V+SCCfus isolates carrying genes for resistance to multiple antibiotics, including aacA-aphD, fusC, inu(A), and tet(K).
Molecular characterization of methicillin-resistant Staphylococcus aureus clinical strains from the endotracheal tubes of patients with nosocomial pneumonia.
The study identified various AMR genes and mutations in MRSA strains from endotracheal tubes, including ermC, ermA, msrA, aac(6')-aph(2"), tetK, and fusB, along with quinolone resistance mutations in gyrA, gyrB, grlA, and grlB.
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
The study identifies known and novel antimicrobial resistance genes using a machine learning approach on pan-genomes of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Key findings include the detection of resistance genes such as gyrA, parC, ermC, lmrS, aac(6')-aph(2"), dfrG, tetK, and various beta-lactamases.
Genotypic and Phenotypic Evaluation of Biofilm Production and Antimicrobial Resistance in Staphylococcus aureus Isolated from Milk, North West Province, South Africa.
The study identified several antimicrobial resistance genes, including blaZ, vanB, tetK, tetL, and msrA/B, in Staphylococcus aureus isolates from milk. These genes were associated with resistance to penicillin, vancomycin, tetracycline, and macrolides. Additionally, biofilm-forming genes icaA, icaB, icaC, icaD, and bap were detected, highlighting the potential public health risk posed by these isolates.
Livestock-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) in Purulent Subcutaneous Lesions of Farm Rabbits.
The study identified multidrug-resistant MRSA strains in farm rabbits, with resistance to tetracycline mediated by the tet(K) gene and resistance to gentamicin mediated by the aac(6')-Ie-aph(2'')-Ia gene.
Characteristics of oral methicillin-resistant Staphylococcus epidermidis isolated from dental plaque.
The study identified multiple AMR genes in methicillin-resistant Staphylococcus epidermidis (MRSE) isolates from dental plaque, including mecA, dfrA, dfrG, aacA-aphD, aadD, aphA3, ermC, msrA, tetK, norA, qacA, and qacC. These genes confer resistance to various antibiotics such as oxacillin, penicillin G, trimethoprim, gentamicin, erythromycin, tetracycline, and quaternary ammonium compounds.
Characterization of Staphylococci and Streptococci Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified multiple AMR genes in Staphylococcus and Streptococcus isolates from bovine milk, including blaZ, mecA, erm(C), aac(aph)D, tetK, tetL, tetM, lnuA, erm(A), erm(B), aphA-3, aad-6, and optrA, indicating widespread resistance to beta-lactams, macrolides, aminoglycosides, tetracyclines, and linezolid.
Phenotypic and Genotypic Assessment of Antibiotic Resistance of Staphylococcus aureus Bacteria Isolated from Retail Meat.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from retail meat, including blaZ, tetK, aacA-D, and ermA, which confer resistance to penicillin, tetracycline, gentamicin, and macrolides/lincosamides/streptogramin B, respectively.
Profiles of Staphyloccocus aureus isolated from goat persistent mastitis before and after treatment with enrofloxacin.
The study identified several AMR genes in Staphylococcus aureus isolates from goat mastitis, including blaZ, ermA, ermB, mecA, tetK, tetM, norA, norC, and lmrS. These genes conferred resistance to various antibiotics such as penicillin, erythromycin, methicillin, tetracycline, and fluoroquinolones.
Identification of Selected Antibiotic Resistance Genes in Two Different Wastewater Treatment Plant Systems in Poland: A Preliminary Study.
The study identified the presence of tetracycline resistance genes (tet(B), tet(K), tet(L), tet(O)) and the sulfonamide resistance gene sulIII in wastewater treatment plant samples. These genes were detected in both raw influent and final effluent samples, indicating their persistence through the treatment process.
Gene dosage variation in Staphylococcus aureus: Implications for immune modulation and pathogenesis
The study identifies csa1 and sdrD as genes that exhibit copy number variation, leading to increased protein expression and affecting immune responses. These variations were shown to influence the immunostimulatory capacity of bacterial supernatants.
Genetic analysis of methicillin-susceptible Staphylococcus aureus clinical isolates: High prevalence of multidrug-resistant ST239 with strong biofilm-production ability.
The study identified high prevalence of multidrug-resistant ST239 isolates with strong biofilm-producing ability. Key AMR genes included mupA, fusC, erm(A), erm(C), ant(4')-Ia, aac(6')-Ie/aph(2''), aph(3')-IIIa, tetM, and tetK.
Staphylococci in poultry intestines: a comparison between farmed and household chickens.
The study identified several AMR genes in staphylococci from poultry intestines, including ermC, mecA, tetK, tetM, and aacA-aphD, which confer resistance to erythromycin, clindamycin, tetracycline, and gentamicin. Multidrug resistance was prevalent among the isolates.
Antimicrobial Resistance Gene Detection and Plasmid Typing Among Multidrug Resistant Enterococci Isolated from Freshwater Environment.
The study identified twelve antimicrobial resistance genes in multidrug-resistant Enterococcus isolates from freshwater, including genes conferring resistance to tetracycline, erythromycin, tylosin, kanamycin, streptomycin, and ciprofloxacin. These genes were detected through PCR and sequencing, highlighting the diversity of resistance mechanisms in environmental Enterococcus.
Antimicrobial Resistance and Virulence of Methicillin-Resistant Staphylococcus aureus from Human, Chicken and Environmental Samples within Live Bird Markets in Three Nigerian Cities.
The study identified various antimicrobial resistance genes in MRSA isolates from human, chicken, and environmental samples in Nigerian live bird markets, highlighting the presence of multidrug-resistant strains and the potential public health risks associated with their dissemination.
Antibiotic resistance and typing of the methicillin-resistant Staphylococcus aureus clones in Kuwait hospitals, 2016-2017.
The study identified various AMR genes in MRSA isolates from Kuwait hospitals, including mupA, aacA-aphD, erm(A), erm(C), tet(K), tet(M), fusC, fusB, and faR1, which conferred resistance to mupirocin, gentamicin, erythromycin, tetracycline, and fusidic acid.
Antimicrobial Resistance of Coagulase-Positive Staphylococcus Isolates Recovered in a Veterinary University Hospital.
The study identified various antimicrobial resistance genes in methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates, including blaZ, erm(B), erm(C), aph(3'), ant(6), aad(6), SAT-4, cat(pc221), dfr(G), tet(K), and tet(M). These genes were associated with resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, trimethoprim, and tetracycline.
Complete Genomic Analysis of VRE From a Cattle Feedlot: Focus on 2 Antibiotic Resistance.
The study identified multiple antibiotic resistance genes in vancomycin-resistant enterococci (VRE) isolates from a cattle feedlot, including vanC1, vanC2/C3, vanXY-C, VanR, macA, macB, rlmA (II), erm(A), aac(6')-la, blaEC, tet(A), tet(L), S10p, gyrA, gyrB, msbA, S12p, rpoB, mdfA/cmr, liaF, liaR, liaS, bcrC, mprF, pgsA, ef-G, ef-TU, ddl, alr, kasA, isotRNA, inhA, fabl, murA, folA, and Dfr, which confer resistance to various antibiotics such as vancomycin, macrolides, aminoglycosides, β-lactams, tetracyclines, quinolones, and others.
Species Distribution, Antimicrobial Resistance, and Enterotoxigenicity of Non-aureus Staphylococci in Retail Chicken Meat.
The study identified tetracycline resistance genes tet(L) and tet(K) in non-aureus staphylococci (NAS) from retail chicken meat, and mutations in the quinolone resistance determining regions (QRDR) of gyrA and parC contributing to fluoroquinolone resistance in S. agnetis and S. chromogenes.
Genomic Characteristics of Colistin-Resistant Salmonella enterica subsp. enterica Serovar Infantis from Poultry Farms in the Republic of Serbia.
The study identified the fosfomycin resistance gene fosA7 and the vgaA gene in Salmonella enterica subsp. enterica serovar Infantis isolates from poultry farms in Serbia. Mutations in the pmrB gene were associated with colistin resistance.
Use of Oral Tetracyclines in the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia: A Literature Review on the Often-Overlooked Antibiotic Class.
The review highlights the mechanisms of resistance to tetracyclines, including efflux pumps (tet(K), tet(L), tet(B)), ribosomal protection proteins (tet(M)), and enzymatic deactivation (tet(X)). These genes confer resistance to tetracycline, doxycycline, minocycline, and omadacycline in various bacterial pathogens.
Whole genome sequencing of coagulase positive staphylococci from a dog-and-owner screening survey.
The study identified several AMR genes in Staphylococcus aureus isolates, including blaZ, tet(K), norA, lmrS, mepR, and fosB, which confer resistance to penicillin, tetracycline, fluoroquinolones, and fosfomycin. No resistance genes were found in S. pseudintermedius isolates.
Antimicrobial resistance and virulence factors in livestock-associated MRSA from German dairy farms
The study identified various antimicrobial resistance genes in livestock-associated MRSA from German dairy farms, including mecA, fexA, tet(K), tet(M), vga(A), vga(E), dfrG, dfrK, aac(6')Ie-aph(2")Ia, str, spc, lsa(E), and erm(A). These genes conferred resistance to beta-lactams, chloramphenicol, tetracyclines, pleuromutilins, trimethoprim, aminoglycosides, streptomycin, spectinomycin, macrolides, lincosamides, and streptogramin B.
A Preliminary Study: Antibiotic Resistance of Escherichia coli and Staphylococcus aureus from the Meat and Feces of Various South African Wildlife Species.
The study identified antibiotic resistance genes in Escherichia coli and Staphylococcus aureus from wildlife meat and feces, including blaCMY, aadA, sul1, sul2, tetA, tetB, tetK, tetL, tetM, vanA, vanB, and blaZ, which conferred resistance to ampicillin, streptomycin, sulfonamides, tetracycline, vancomycin, and penicillin.
Comparative characterisation of human and ovine non-aureus staphylococci isolated in Sardinia (Italy) for antimicrobial susceptibility profiles and resistance genes.
The study identified various AMR genes in non-aureus staphylococci from ovine and human sources, including blaZ, tetK, msrA, ermC, smr, and qacA/B, which confer resistance to penicillin, tetracycline, erythromycin, and antiseptics.
Occurrence of Antibiotic Resistance Genes in Hermetia illucens Larvae Fed Coffee Silverskin Enriched with Schizochytrium limacinum or Isochrysis galbana Microalgae.
The study identified several tetracycline resistance genes (tet(M), tet(S), tet(K)), erythromycin resistance genes (erm(B), erm(C)), a methicillin resistance gene (mecA), and an aminoglycoside resistance gene (aac(6')-Ib) in Hermetia illucens larvae and frass. The presence of these genes suggests potential safety concerns regarding the reuse of frass in agriculture.
Genome-Wide Analysis of Staphylococcus aureus Sequence Type 72 Isolates Provides Insights Into Resistance Against Antimicrobial Agents and Virulence Potential.
The study identified several AMR genes in ST72 isolates, including blaZ, aadD, ermC, msr(A), mph(C), tetK, aac(6')-aph(2'), fusC, and dfrG, which confer resistance to various antibiotics. K07-204 showed resistance to methicillin, ampicillin, erythromycin, kanamycin, and tetracycline, while K07-561 exhibited resistance to ampicillin and tetracycline. Additionally, K07-204 was found to be highly resistant to lysostaphin.
Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections.
The study identified antimicrobial resistance genes qacA, dfrG, and qacC in Staphylococcus saprophyticus isolates, highlighting their role in resistance to quaternary ammonium compounds, trimethoprim, and biocides respectively.
Clonal Diversity and Antimicrobial Resistance of Methicillin-Resistant Staphylococcus pseudintermedius Isolated from Canine Pyoderma.
All 31 MRSP isolates were multidrug-resistant, showing resistance to penicillin, macrolides, lincosamides, aminoglycosides, tetracycline, and trimethoprim-sulfamethoxazole. Key resistance genes identified include blaZ, ermB, msr(A/B), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, ant(4')-Ia, tetM, tetK, and dfrG.
Whole Genome Sequencing and Antimicrobial Resistance of Staphylococcus aureus from Surgical Site Infections in Ghana.
The study identified blaZ, mecA, and tet(K) as the main antimicrobial resistance genes in Staphylococcus aureus isolates from surgical site infections in Ghana. These genes conferred resistance to penicillin, methicillin, and tetracycline, respectively.
Profiles of coagulase-positive and -negative staphylococci in retail pork: prevalence, antimicrobial resistance, enterotoxigenicity, and virulence factors.
The study identified the tetracycline resistance gene tet(K) in various coagulase-negative staphylococci (CoNS) isolated from retail pork, highlighting its prevalence and association with tetracycline resistance.
A platform for detecting cross-resistance in antibacterial drug discovery.
The study presents a cross-resistance platform (CRP) consisting of 28 Staphylococcus aureus strains with defined resistance genotypes, designed to detect cross-resistance between established and novel antibacterial agents. The CRP includes various AMR genes and mutations that confer resistance to multiple antibiotic classes.
Staphylococcus aureus in Intensive Pig Production in South Africa: Antibiotic Resistance, Virulence Determinants, and Clonality.
The study identified several AMR genes in S. aureus isolates from intensive pig production in South Africa, including ermC, blaZ, tetK, aac(6')-aph(2"), and mecA, which confer resistance to erythromycin, penicillin, tetracycline, gentamicin, and methicillin respectively.
Culture-Independent Genotyping, Virulence and Antimicrobial Resistance Gene Identification of Staphylococcus aureus from Orthopaedic Implant-Associated Infections.
The study identified blaZ and tetK as genes conferring resistance to penicillin and tetracycline, respectively, in Staphylococcus aureus from orthopaedic implant-associated infections using nanopore shotgun metagenomic sequencing.
Genomic Analysis of Staphylococcus aureus of the Lineage CC130, Including mecC-Carrying MRSA and MSSA Isolates Recovered of Animal, Human, and Environmental Origins.
The study identified several AMR genes in Staphylococcus aureus CC130 isolates, including mecC, blaZ, tet(K), arsB, and arsC. These genes conferred resistance to methicillin, penicillin, tetracycline, arsenite, and arsenate. The presence of the IEC system in some mecC-positive MRSA-CC130 strains suggests potential human adaptation.
Evaluation of commercial probiotics for antimicrobial resistance genes.
The study found that 94% of the evaluated commercial probiotics contained at least one transferable antimicrobial resistance (AMR) gene, with 82% containing two or more. The most commonly detected AMR genes were tetK (68%) and sul2 (60%).
The First Report of a Methicillin-Resistant Staphylococcus aureus Isolate Harboring Type IV SCCmec in Thailand.
The study reports the first identification of a methicillin-resistant Staphylococcus aureus (MRSA) isolate harboring type IV SCCmec in Thailand. Five acquired antimicrobial resistance genes, including blaZ, mecA, Inu(A), tet(K), and dfrG, were identified, conferring resistance to beta-lactams, lincosamides, tetracycline, and trimethoprim.
Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureus.
The paper discusses the mechanisms of antibiotic resistance in methicillin-resistant Staphylococcus aureus (MRSA), focusing on genes such as blaZ, mecA, and dltA, which are involved in beta-lactam and glycopeptide resistance. It highlights the importance of understanding these resistance mechanisms to develop new therapeutic strategies.
A Real-Time Thermal Sensor System for Quantifying the Inhibitory Effect of Antimicrobial Peptides on Bacterial Adhesion and Biofilm Formation.
The study identified several AMR genes in E. coli and S. aureus isolates, including beta-lactamases (blaOXA-1, blaTEM-1A), chloramphenicol acetyltransferase (catA1), trimethoprim resistance gene (dfrA1), fluoroquinolone resistance gene (floR), sulfonamide resistance genes (sul1, sul2), methicillin resistance gene (mecA), beta-lactamase (blaZ-like), and tetracycline efflux pumps (tet(K), tet(M)).
Staphylococcus epidermidis Phages Transduce Antimicrobial Resistance Plasmids and Mobilize Chromosomal Islands.
The study identifies several antimicrobial resistance genes, including aad(6), tetK, bla, erm, and cat, which confer resistance to streptomycin, tetracycline, chloramphenicol, and erythromycin. These genes were transferred via phage-mediated transduction in Staphylococcus epidermidis.
Antibiotic resistance profiles and population structure of disease-associated Staphylococcus aureus infecting patients in Fort Portal Regional Referral Hospital, Western Uganda.
The study identified various AMR genes in S. aureus isolates from Fort Portal Regional Referral Hospital, including blaZ, dfrA, dfrG, ermA, ermC, msrA, tetK, and tetM, contributing to resistance against multiple antibiotics. Additionally, mecA was detected, indicating methicillin resistance.
Virulence Factors in Staphylococcus Associated with Small Ruminant Mastitis: Biofilm Production and Antimicrobial Resistance Genes.
The study identified the blaZ gene in several Staphylococcus species, including S. chromogenes, S. aureus, S. warneri, S. auricularis, S. caprae, and S. simulans, which conferred resistance to penicillin. Additionally, the tetK and tetM genes were found in S. aureus isolates, providing resistance to tetracycline.
Antimicrobial Resistance Profiles and Genes of Staphylococci Isolated from Mastitic Cow's Milk in Kenya.
The study identified several antimicrobial resistance genes in staphylococci isolated from mastitic cow's milk in Kenya, including blaZ, strB, msrA, ermB, tetM, and tetK, which confer resistance to beta-lactams, streptomycin, erythromycin, and tetracycline.
Antimicrobial Susceptibility of Lactic Acid Bacteria Strains of Potential Use as Feed Additives - The Basic Safety and Usefulness Criterion.
The study identified several AMR genes in LAB strains, including aph(3")-IIIa, erm(B), lnu(A), msr(C), tet(K), and tet(M), which confer resistance to aminoglycosides, macrolides, lincomycins, and tetracyclines. These findings highlight the potential of LAB as reservoirs of AMR genes.
Analysis of Virulence and Antimicrobial Resistance Gene Carriage in Staphylococcus aureus Infections in Equids Using Whole-Genome Sequencing.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from equids, including blaZ, mupA, lnuA, tetK, tetL, tetM, norA, dfrC, dfrG, dfrK, ermA, ermC, msrA, mphC, qacA/B, qacC, and fosB. An isolate (17-021) was found to carry the lnuA gene and mupA plasmid, conferring resistance to clindamycin and mupirocin. A mutation in the prs gene was associated with phenotypic susceptibility to β-lactam drugs in a mecA-positive isolate.
The Resistome and Mobilome of Multidrug-Resistant Staphylococcus sciuri C2865 Unveil a Transferable Trimethoprim Resistance Gene, Designated dfrE, Spread Unnoticed.
The study identifies and characterizes the transferable trimethoprim resistance gene dfrE in Staphylococcus sciuri C2865, which confers high-level resistance in Staphylococcus aureus and Escherichia coli.
Genomic Analysis of Antibiotic-Resistant Staphylococcus epidermidis Isolates From Clinical Sources in the Kwazulu-Natal Province, South Africa.
The study identified multiple antibiotic resistance genes in methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, tet(K), erm(A), erm(B), erm(C), dfrG, aac(6')-aph(2''), and cat(pC221), which confer resistance to beta-lactams, tetracyclines, macrolides, lincosamides, streptogramin B, trimethoprim, aminoglycosides, and chloramphenicol.
Prevalence and Characteristics of Staphylococcus aureus Isolated From Retail Raw Milk in Northern Xinjiang, China.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from retail raw milk in northern Xinjiang, China, including blaZ, mecA, ermA, ermB, ermC, aacA-aphD, tetK, tetM, vanA, rpoB, linA, optrA, and cfr, which confer resistance to penicillin, methicillin, oxacillin, erythromycin, gentamicin, tetracycline, vancomycin, rifampin, clindamycin, linezolid, chloramphenicol, and florfenicol.
Environmental Surveillance and Characterization of Antibiotic Resistant Staphylococcus aureus at Coastal Beaches and Rivers on the Island of Hawai'i.
The study identified various antibiotic resistance genes in Staphylococcus aureus isolates from coastal beaches and rivers on the island of Hawai'i, highlighting the presence of multidrug-resistant strains.
Molecular Characterization of Staphylococcus aureus Isolated from Raw Milk Samples of Dairy Cows in Manhiça District, Southern Mozambique.
The study identified several AMR genes in S. aureus isolates from raw milk samples, including blaZ for penicillin resistance, tetK for tetracycline resistance, mecA for methicillin resistance, ermC for erythromycin and clindamycin resistance, and dfrG for co-trimoxazole resistance.
Vancomycin resistant Streptococcus equi subsp. equi isolated from equines suffering from respiratory manifestation in Egypt.
The study identified vancomycin-resistant Streptococcus equi subsp. equi isolates carrying the vanA gene, along with tetK, blaZ, and fexA genes, indicating resistance to vancomycin, tetracycline, penicillin, and chloramphenicol, respectively.
Genomic Investigation of Methicillin-Resistant Staphylococcus aureus ST113 Strains Isolated from Tertiary Care Hospitals in Pakistan.
The study identified several AMR genes in MRSA ST113 strains, including aph(3')-IIIa, aad(6), sat-4, tet(K), mupA, and ant(4')-Ib, along with a point mutation in fusA conferring resistance to fusidic acid.
A survey of prevalence and phenotypic and genotypic assessment of antibiotic resistance in Staphylococcus aureus bacteria isolated from ready-to-eat food samples collected from Tehran Province, Iran.
The study identified several AMR genes in S. aureus isolates from ready-to-eat food samples, including blaZ, aacA-D, tetK, ermA, and gyrA, which conferred resistance to penicillin, aminoglycosides, tetracyclines, macrolides, and fluoroquinolones.
Incidence of Tetracycline and Erythromycin Resistance in Meat-Associated Bacteria: Impact of Different Livestock Management Strategies.
The study identified tet K, tet M, erm B, and erm C as the primary genes responsible for tetracycline and erythromycin resistance in meat-associated bacteria, highlighting the impact of livestock management strategies on the spread of antibiotic resistance.
Molecular Characterization of Staphylococcus aureus Isolated from Human and Food Samples in Northern Algeria.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from human and food samples in northern Algeria, including blaZ, ermB, ermC, aphA3, sat, tetK, and tetM.
Antibiotic sensitivity patterns in Staphylococcus spp. isolated from goat milk in association with molecular detection of antibiotic resistance genes.
The study identified several antibiotic resistance genes in Staphylococcus spp. isolated from goat milk, including blaZ, mecA, tetK, and tetM, which confer resistance to penicillin, methicillin, and tetracycline.
Molecular Typing and Antimicrobial Susceptibility Profiles of Streptococcus uberis Isolated from Sheep Milk.
The study identified resistance genes ermB, ermC, blaZ, tetM, tetO, and tetK in Streptococcus uberis isolates from sheep milk, contributing to resistance against erythromycin, penicillin, and tetracycline.
Genetic Characterization of Staphylococcus aureus From Subclinical Mastitis Cases in Dairy Cows in Rwanda.
The study identified the blaZ gene conferring penicillin resistance in 84% of the isolates, tet(K) or tetM genes for tetracycline resistance in 20% of the isolates, and the dfrG gene for trimethoprim resistance in 28% of the isolates.
Genomic Analysis of Global Staphylococcus argenteus Strains Reveals Distinct Lineages With Differing Virulence and Antibiotic Resistance Gene Content.
The study identifies several antibiotic resistance genes in Staphylococcus argenteus, including blaZ, mecA, and fosB, which confer resistance to penicillin, methicillin, and fosfomycin, respectively. These genes were found in different lineages and geographic regions.
Prevalence and antimicrobial resistance profiling of Staphylococcus aureus isolated from traditional cheese in Yunnan, China.
The study identified 18 antimicrobial resistance genes in Staphylococcus aureus strain DC.RB_015, including mecA, blaZ, mepA, tet(K), tet(38), arlR, arlS, norA, mgrA, LmrS, APH(3′)-IIIa, aad(6), ErmB, SAT-4, mecR1, GlpT, murA, and bacA, which confer resistance to various antibiotics such as methicillin, beta-lactam, tetracycline, fluoroquinolone, macrolide, aminoglycoside, nucleoside, fosfomycin, and bacitracin.
Detection, molecular characterization, and antibiogram of multi-drug resistant and methicillin-resistant Staphylococcus aureus (MRSA) isolated from pets and pet owners in Malaysia.
The study identified multiple AMR genes including mecA, tetK, tetL, ermA, ermB, ermC, msrA, scn, chp, sak, sea, and sep in S. aureus isolates from pets and pet owners in Malaysia, indicating the presence of multidrug-resistant and methicillin-resistant strains.
Antimicrobial and Biocide Resistance among Feline and Canine Staphylococcus aureus and Staphylococcus pseudintermedius Isolates from Diagnostic Submissions.
The study identified various antimicrobial resistance genes in feline and canine Staphylococcus aureus and Staphylococcus pseudintermedius isolates, including blaZ, mecA, mecC, tet(K), tet(M), erm(A), erm(B), erm(C), erm(T), msr(A), aadE, aacA-aphD, aphA3, aadD, dfrG, lnu(B), and lsa(E). These genes conferred resistance to multiple antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, and others.
Frequently used therapeutic antimicrobials and their resistance patterns on Staphylococcus aureus and Escherichia coli in mastitis affected lactating cows.
The study identified several antimicrobial resistance genes in Staphylococcus aureus and Escherichia coli isolated from mastitis-affected cows, including mecA, tetK, tetL, tetA, tetB, sul1, and sul2. These genes confer resistance to various antibiotics such as tetracycline, sulfamethoxazole-trimethoprim, and methicillin.
Growth-Dependent Predation and Generalized Transduction of Antimicrobial Resistance by Bacteriophage
The study demonstrates that generalized transduction by bacteriophages can rapidly transfer antimicrobial resistance genes between Staphylococcus aureus strains, leading to the formation of double-resistant progeny. The resistance genes erm(B) and tet(K) were identified as responsible for erythromycin and tetracycline resistance, respectively.
Multidrug-Resistant Methicillin-Resistant Coagulase-Negative Staphylococci in Healthy Poultry Slaughtered for Human Consumption.
The study identified multiple multidrug-resistant methicillin-resistant coagulase-negative staphylococci (MRCoNS) in poultry, carrying genes such as mecA, ermA, ermB, ermC, mphC, aph(3')-IIIa, ant(4')-Ia, str, tetK, tetL, tetM, tetO, cfr, dfrK, dfrD, and cat p194, which confer resistance to various antibiotics.
A One Health Approach Molecular Analysis of Staphylococcus aureus Reveals Distinct Lineages in Isolates from Miranda Donkeys (Equus asinus) and Their Handlers.
The study identified various antimicrobial resistance genes in Staphylococcus aureus and coagulase-negative staphylococci (CoNS) isolates from Miranda donkeys and their handlers, including blaZ, aph(3')-IIIa, tetK, tetL, tetM, lnuA, ermB, ermC, mecA, and optrA. These genes confer resistance to penicillins, aminoglycosides, tetracyclines, lincomycins, macrolides, lincosamides, streptogramin B, methicillin, and linezolid.
Beyond CC398: Characterisation of Other Tetracycline and Methicillin-Resistant Staphylococcus aureus Genetic Lineages Circulating in Spanish Hospitals.
The study characterizes various tetracycline and methicillin-resistant Staphylococcus aureus genetic lineages circulating in Spanish hospitals, identifying multiple AMR genes including blaZ, tetK, tetL, tetM, ermC, ermB, ant(4')-Ia, aac(6')-Ie-aph(2'')-Ia, mupA, and fusB.
Antimicrobial resistance determinants in silage.
The study identified 16 antimicrobial resistance genes (ARGs) in silage samples, highlighting their potential to spread through the food chain and contribute to antimicrobial resistance.
Multidrug-resistant and enterotoxigenic methicillin-resistant Staphylococcus aureus isolated from raw milk of cows at small-scale production units.
The study identified multidrug-resistant and enterotoxigenic methicillin-resistant Staphylococcus aureus (MRSA) in raw milk from cows at small-scale production units. The MRSA isolates exhibited resistance to β-lactams, tetracycline, and norfloxacin, with specific resistance genes such as blaZ, mecA, tetK, and norA detected. Enterotoxin genes like seb were also identified in MRSA isolates.
The Emergence of a Multidrug-Resistant and Pathogenic ST42 Lineage of Staphylococcus haemolyticus from a Hospital in China.
The study identifies the ST42 lineage of Staphylococcus haemolyticus as a multidrug-resistant and pathogenic clone with a high burden of antibiotic resistance genes (ARGs) and virulence determinants.
Antimicrobial Resistance and Clonal Lineages of Staphylococcus aureus from Cattle, Their Handlers, and Their Surroundings: A Cross-Sectional Study from the One Health Perspective.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from cattle, farm workers, and their environment, highlighting the potential for transmission between hosts and the need for monitoring AMR in One Health contexts.
Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance.
The paper discusses the resurgence of tetracycline-class antibiotics, highlighting their effectiveness against various bacterial infections, including those resistant to other antibiotics. It identifies key resistance mechanisms such as efflux pumps and ribosomal protection proteins, and emphasizes the importance of these antibiotics in combating multidrug-resistant pathogens.
Detection of Antibiotic Resistance, Virulence Gene, and Drug Resistance Gene of Staphylococcus aureus Isolates from Bovine Mastitis.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from bovine mastitis, including blaZ, aacA-aphD, tetK, tetM, norA, norB, norC, and mecA. These genes were associated with resistance to various antibiotics such as penicillin G, gentamicin, kanamycin, tetracycline, and ciprofloxacin.
Antimicrobial resistance and virulence factors in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis in low-resource settings
The study identifies various antimicrobial resistance genes in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis, including mecA, tet(K), tet(M), tet(L), aadD, aph(3)-III, ermA, ermC, msrA, mphC, and IS256. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in low-resource settings.
Assessment of multidrug-resistant Listeria monocytogenes in milk and milk product and One Health perspective.
The study identified multiple antimicrobial resistance genes in Listeria monocytogenes isolates from milk and milk products, including beta-lactamase genes (bla TEM, bla SHV, bla Z), tetracycline resistance genes (tet A, tet D, tet G, tet K, tet M), sulfonamide resistance genes (sul 1, sul 2), and an aminoglycoside resistance gene (aph (3)-IIa (aphA2)).
Novel Organization of the Staphylococcal Cassette Chromosome mec Composite Island in Clinical Staphylococcus haemolyticus and Staphylococcus hominis Subsp. hominis Isolates from Dogs.
The study identified novel SCC mec composite islands in clinical Staphylococcus haemolyticus and Staphylococcus hominis subsp. hominis isolates from dogs, including the aminoglycoside resistance gene aph(2")-Ia, the trimethoprim resistance gene dfrC, and the tetracycline resistance gene tet(K).
Antimicrobial resistance and genomic analysis of staphylococi isolated from livestock and farm attendants in Northern Ghana.
The study identified several AMR genes in staphylococci from livestock and farm attendants in Northern Ghana, including mecA1, mecA, tet(K), tet(L), tet(M), cat(pC221), sal(A), aadD, dfrK, dfrG, erm(B), fosB, aac(6')-aph(2''), and blaZ, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, aminoglycosides, and macrolides.
Antimicrobial Susceptibility Profiles and Molecular Characterisation of Staphylococcus aureus from Pigs and Workers at Farms and Abattoirs in Zambia.
The study identified tetracycline resistance genes (tetM, tetK, tetL) and erythromycin resistance genes (ermB, ermC) in Staphylococcus aureus isolates from pigs and workers in Zambia. These genes were detected through PCR and are associated with resistance to tetracycline and erythromycin, highlighting the need for continued surveillance of antimicrobial resistance in this region.
Whole-Genome Sequence of Multidrug-Resistant Methicillin-Resistant Staphylococcus epidermidis Carrying Biofilm-Associated Genes and a Unique Composite of SCCmec.
The study identified multiple antimicrobial resistance genes in multidrug-resistant methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, fusB, fosB, aadD, aac(6')-aph(2"), tet(K), dfrG, msr(A), and qacA. These genes contribute to resistance against various antibiotics such as methicillin, penicillin, fusidic acid, fosfomycin, aminoglycosides, tetracycline, trimethoprim, macrolides, and chlorhexidine.
Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of drug resistance in Staphylococcus aureus, focusing on beta-lactam, glycopeptide, oxazolidinone, MLS-B, aminoglycoside, and other resistance mechanisms. Key genes identified include blaZ, mecA, mecC, vanA, cfr, ermA, ermC, aac(6')-Ib, aph(3')-IIIa, and aadD. Mutations in pbp2 and pbp2a were also found to contribute to resistance.
Methicillin Resistant Staphylococci Isolated from Goats and Their Farm Environments in Saudi Arabia Genotypically Linked to Known Human Clinical Isolates: a Pilot Study.
The study identified several AMR genes in methicillin-resistant staphylococci isolates from goats and their farm environments in Saudi Arabia, including mecA, blaZ, norA, lmrS, mepA, mepR, arlR, arlS, tet(38), mecR1, dfrC, fusC, fosB, fexA, tetM, msrA, mphC, fusB, APH(3′)-IIIa, tetK, and dfrG. These genes confer resistance to various antibiotics such as penicillins, fluoroquinolones, aminoglycosides, macrolides, phenicols, diaminopyrimidines, oxazolidinones, tetracyclines, and fosfomycin.
Comparison between Some Phenotypic and Genotypic Methods for Assessment of Antimicrobial Resistance Trend of Bovine Mastitis Staphylococcus aureus Isolates from Bulgaria.
The study identified blaZ, mecA, ermC, and tetK genes in Staphylococcus aureus isolates from bovine mastitis cases in Bulgaria, highlighting resistance to penicillin, methicillin, erythromycin, and tetracycline.
Whole-Genome Analysis of Staphylococcus aureus Isolates from Ready-to-Eat Food in Russia.
The study identified multiple antimicrobial resistance (AMR) genes in Staphylococcus aureus isolates from ready-to-eat food in Russia, including blaZ, mecA, inuA, cat, ermC, dfrG, dfrK, aaC, aaD, ant(9)-Ia, tet(K), tet(cluster), erm(A), erm(C), cat(pC194), and fexA. These genes conferred resistance to various antibiotics such as penicillins, lincosamides, phenicols, macrolides, aminoglycosides, tetracyclines, and fluoroquinolones.
Balancing the Virulence and Antimicrobial Resistance in VISA DAP-R CA-MRSA Superbug.
The study identifies several AMR genes, including ant(6)-Ia, aph(3')-III, blaZ, mecA, ermC, and tetK, which contribute to resistance against aminoglycosides, beta-lactams, macrolides, and tetracyclines in VISA DAP-R CA-MRSA. Additionally, a mutation in mprF (Thr345Ala) is linked to daptomycin and glycopeptide resistance.
Antimicrobial Resistance, Virulence Profiles, and Public Health Significance of Enterococcus faecalis Isolated from Clinical Mastitis of Cattle in Bangladesh.
The study identified tetracycline resistance genes tetK, tetL, and tetM, as well as aminoglycoside resistance genes aacC2, aacC4, and aph(3'')-IIIa, and the vancomycin resistance gene vanB in Enterococcus faecalis isolates from bovine clinical mastitis in Bangladesh.
Genomic Characterization and Antimicrobial Susceptibility of Dromedary-Associated Staphylococcaceae from the Horn of Africa.
The study identified several antimicrobial resistance genes in Staphylococcaceae isolates from camels and cattle in East Africa, including tet(K), blaZ, blaARL, mecA, mecA1, msrA, mphC, salA, dfrG, aacA-aphD, and str. These genes were associated with resistance to tetracycline, benzylpenicillin, oxacillin, erythromycin, clindamycin, trimethoprim, gentamicin, and streptomycin.
Emergence of Cfr-Mediated Linezolid Resistance among Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) from Healthy Pigs in Portugal.
The study identified the cfr gene as a mediator of linezolid resistance in livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) from healthy pigs in Portugal. Additional resistance genes such as blaZ, mecA, fexA, tet(M), and tet(K) were also characterized.
Antimicrobial Resistance and Virulence Genes in Staphylococci Isolated from Aviary Capercaillies and Free-living Birds in South-eastern Poland.
The study identified several AMR genes in Staphylococcus isolates from birds, including mecA, blaZ, msrA/B, ermC, mphC, tetK, tetM, cfr, norA, aac(6')-aph(2"), sea, and tst. These genes conferred resistance to various antibiotics such as methicillin, beta-lactams, macrolides, tetracyclines, chloramphenicol, florfenicol, fluoroquinolones, and aminoglycosides.
Alarming Antibiotic Resistance of Lactobacilli Isolated from Probiotic Preparations and Dietary Supplements.
The study identified vancomycin resistance gene vanX, ciprofloxacin resistance gene parC, extended-spectrum beta-lactamase gene blaTEM, and tetracycline resistance gene tetK in Lactobacillus isolates from probiotic products.
Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcus aureus from Nasal Specimens: Overcoming MRSA with Silver Nanoparticles and Their Applications.
The study identified methicillin-resistant Staphylococcus aureus (MRSA) isolates carrying resistance genes mecA, aacA-aphD, tetM, ermA, tetK, and vatABC. These genes conferred resistance to multiple antibiotics, including methicillin, tetracycline, aminoglycosides, and macrolides. The study also highlighted the potential of silver nanoparticles in enhancing the efficacy of antibiotics against MRSA.
Modelling the synergistic effect of bacteriophage and antibiotics on bacteria: Killers and drivers of resistance evolution.
The study characterizes the ermB and tetK genes as conferring resistance to erythromycin and tetracycline, respectively, in Staphylococcus aureus strains NE327 and NE201KT7. These genes were experimentally validated in the study.
Detection of Methicillin-Resistant Staphylococcus aureus in Clinical and Subclinical Mastitis in Ruminants and Studying the Effect of Novel Green Synthetized Nanoparticles as One of the Alternative Treatments.
The study identified methicillin-resistant Staphylococcus aureus (MRSA) in mastitic milk samples from ruminants and characterized resistance genes including mecA, blaZ, ermB, tetM, and tetK. Green synthesized titanium dioxide nanoparticles (TiO2 NPs) showed potent antibacterial activity against MRSA.
Dispersion and persistence of antimicrobial resistance genes among Staphylococcus spp. and Mammaliicoccus spp. isolated along a swine manure treatment plant.
The study identified multiple antimicrobial resistance genes, including fexA, ermC, cfr, aac(6')-aph(2''), dfrG, tetK, blaZ, mecA, norA, tetM, and ermA, in Staphylococcus and Mammaliicoccus species isolated from a swine manure treatment plant, indicating widespread resistance to various antibiotics.
Methicillin-Resistant Staphylococcus aureus from Diabetic Foot Infections in a Tunisian Hospital with the First Detection of MSSA CC398-t571.
The study identified several AMR genes in S. aureus isolates from diabetic foot infections, including blaZ, erm(B), erm(A), msrA, tet(M), tet(K), tet(L), aac(6')-aph(2"), ant(4')-Ia, and fexA. These genes conferred resistance to various antibiotics such as penicillin, erythromycin, tetracycline, gentamicin, tobramycin, and chloramphenicol.
Plasmid-Coded Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus from Food and Livestock in Germany.
Two linezolid-resistant MRSA strains from pigs in Germany were identified, both harboring plasmid-encoded cfr genes. These strains also had additional AMR genes, indicating multidrug resistance.
Phenotypic and Genotypic Virulence Characterisation of Staphylococcus pettenkoferi Strains Isolated from Human Bloodstream and Diabetic Foot Infections.
The study characterizes several AMR genes and mutations in Staphylococcus pettenkoferi strains, including blaZ, mecA, ant(9)-Ia, tet(K), ermA, vgaA, and fosB, as well as mutations in rpoB, gyrA, glrA, and grlB.
Staphylococcus aureus from Subclinical Cases of Mastitis in Dairy Cattle in Poland, What Are They Hiding? Antibiotic Resistance and Virulence Profile.
The study identified tet(K) and blaZ as the primary antibiotic resistance genes in Staphylococcus aureus isolates from subclinical mastitis cases in Polish dairy cattle, with resistance to tetracycline and penicillin being prevalent.
Comparative Genomic Analysis of a Multidrug-Resistant Staphylococcus hominis ShoR14 Clinical Isolate from Terengganu, Malaysia, Led to the Discovery of Novel Mobile Genetic Elements.
The study identified multiple AMR genes in the multidrug-resistant S. hominis ShoR14 isolate, including tetK, norA, aac(6')-aph(2"), aadD, blaZ, mecA, mupA, fusC, ermC, sul4, dfrC, and catA7, which contribute to resistance against various antibiotics.
Characteristics of Staphylococcus aureus Isolated from Patients in Busia County Referral Hospital, Kenya.
The study identified S. aureus isolates carrying genes conferring resistance to penicillin-G, trimethoprim, tetracycline, erythromycin, gentamicin, and other antibiotics. Key resistance genes included blaZ, tetK, tetM, dfrG, ermA, ermC, aacA-aphD, aad9, and mecA.
Resistome and virulome diversity of foodborne pathogens isolated from artisanal food production chain of animal origin in the Mediterranean region.
The study identified various AMR genes in L. monocytogenes, Salmonella enterica, and S. aureus isolates from artisanal food production chains in the Mediterranean region, highlighting the presence of fosfomycin, aminoglycoside, beta-lactam, trimethoprim, sulfonamide, tetracycline, and streptomycin resistance mechanisms.
Farming Practice Influences Antimicrobial Resistance Burden of Non-Aureus Staphylococci in Pig Husbandries.
The study found that organic and alternative pig farming practices are associated with reduced antimicrobial resistance (AMR) in non-aureus staphylococci (NAS) compared to conventional farming. Specific AMR genes such as mecA, blaZ, blaPC1, and others were more prevalent in conventional farms, while organic farms showed lower levels of AMR genes for aminoglycosides, phenicols, and tetracyclines.
Molecular Epidemiology of Group B Streptococcus Isolates from Pregnant Women with Premature Rupture of Membranes in Fuzhou, China.
The study identified several AMR genes in GBS isolates from pregnant women with PROM in Fuzhou, China, including mreA, ermB, mefA, mefE, ermA, ermTR, tetM, and tetK, which are associated with resistance to erythromycin and tetracycline.
Molecular epidemiology, drug resistance, and virulence gene analysis of Streptococcus agalactiae isolates from dairy goats in backyard farms in China.
The study identified multiple AMR genes in S. agalactiae isolates from dairy goats in China, including pbp2b, tetL, tetM, tetK, tetO, ermA, ermB, mefA, aphA3, aad6, lnu(B), gryA, and parC, which confer resistance to various antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, lincosamides, and quinolones.
Antimicrobial Resistance and Virulence Genes of Streptococcus Agalactiae Isolated from Mastitis Milk Samples in China.
The study identified several AMR genes in multidrug-resistant Streptococcus agalactiae isolates from bovine mastitis milk samples in China, including ermB, ermA, lnuA, tetM, tetK, tetS, and tetO. These genes conferred resistance to macrolides, lincosamides, and tetracyclines.
Phylogenetic Analysis and Virulence Characteristics of Methicillin-Resistant Staphylococcus aureus ST45 in China: a Hyper-Virulent Clone Associated with Bloodstream Infections.
The study identifies the presence of antimicrobial resistance genes blaZ, tetK, aac6 aph2, and ermC in MRSA ST45 isolates, highlighting their resistance to beta-lactam, tetracycline, aminoglycoside, and macrolide-lincosamide-streptomycin antibiotics. Additionally, the research emphasizes the high virulence potential of ST45-MRSA isolates in causing bloodstream infections.
Panton-Valentine Leukocidin-Positive CC398 MRSA in Urban Clinical Settings, the Netherlands.
The study identified PVL-positive CC398 MRSA strains in the Netherlands, highlighting their potential for community acquisition and the importance of genomic surveillance for early detection.
Prevalence, multiple antibiotic resistance and virulence profile of methicillin-resistant Staphylococcus aureus (MRSA) in retail poultry meat from Edo, Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus (MRSA) isolated from retail poultry meat in Edo, Nigeria, highlighting the prevalence of multidrug-resistant MRSA and the presence of virulence factors that pose a public health concern.
Staphylococcus aureus Carriage in the Nasotracheal Cavities of White Stork Nestlings (Ciconia ciconia) in Spain: Genetic Diversity, Resistomes and Virulence Factors.
The study identified several AMR genes in Staphylococcus aureus isolates from white stork nestlings, including blaZ, ermA, ermT, tetK, and lnuA, which confer resistance to penicillin, erythromycin, clindamycin, and tetracycline. Most isolates were methicillin-susceptible (MSSA) with low levels of AMR.
Clonal Spreading of ST42 Staphylococcus haemolyticus Strains Occurs Possibly Due to fusB and tetK Resistant Genes and Capsule-Related Genes.
The study identifies fusB and tetK as key resistance genes contributing to the clonal spread of ST42 Staphylococcus haemolyticus strains, along with capsule-related genes.
Antimicrobial Usage and Detection of Multidrug-Resistant Staphylococcus aureus: Methicillin- and Tetracycline-Resistant Strains in Raw Milk of Lactating Dairy Cattle.
The study identified the methicillin resistance gene mecA in 9 out of 11 multidrug-resistant S. aureus isolates and the tetracycline resistance gene tetK in 7 out of 11 isolates from raw milk samples.
Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcaceae (MRS) and Mammaliicocci (MRM) in Dromedary Camels from Algeria: First Detection of SCCmec-mecC Hybrid in Methicillin-Resistant Mammaliicoccus lentus.
The study identified methicillin-resistant Staphylococcus and Mammaliicoccus species in dromedary camels in Algeria, including the first detection of a SCCmec-mecC hybrid in Mammaliicoccus lentus. Key resistance genes identified include mecA, mecC, blaZ, aadD, dfrG, ermB, ermA, msrA, mphC, fosB, fusB, and tet(K).
The Plasmidomic Landscape of Clinical Methicillin-Resistant Staphylococcus aureus Isolates from Malaysia.
The study identified various plasmid-borne antimicrobial resistance genes in Malaysian MRSA isolates, including ermC, cat, tetK, tetL, aadD, aac(6')-Ie-aph(2")-Ia, lnuA, cadAC, cadDX, copB, mco, arsB, arsC, and qacA, contributing to multidrug resistance.
Antibiotic Resistance Profiles and ARG Detection from Isolated Bacteria in a Culture-Dependent Study at the Codfish Industry Level.
The study identified various antibiotic resistance genes in bacteria isolated from codfish products and environmental samples, highlighting the presence of tetracycline, clindamycin, and oxacillin resistance genes in Staphylococcus spp., as well as beta-lactam and carbapenem resistance genes in Gram-negative bacteria.
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
The study identified numerous antimicrobial resistance (AMR) genes in methicillin-resistant Staphylococcus aureus (MRSA) CC398 isolates from diseased swine in Germany, including beta-lactam, tetracycline, macrolide, lincosamide, streptogramin B, phenicol, aminoglycoside, and fluoroquinolone resistance genes. These genes were often located on small transposons or plasmids, contributing to the multidrug resistance profile of the isolates.
Virulence Signatures, Integrons, and Antibiotic Resistance Genes in Bacterial Strains Recovered from Selected Commercial Dairy Products and Fresh Raw Meat.
The study identified antibiotic resistance genes such as tetK, linA, and ermA in bacterial strains from dairy products and raw meat, highlighting the presence of multidrug-resistant bacteria and potential public health concerns.
Antimicrobial resistance in bacteria isolated from peridomestic Rattus species: A scoping literature review.
This scoping review identifies various antimicrobial resistance (AMR) genes in bacteria isolated from peridomestic Rattus species, including beta-lactamases (bla TEM, bla CTX-M, bla SHV, bla VIM, bla IMP, bla NDM-1), aminoglycoside resistance genes (strA, strB, aadA, aphA), sulfonamide resistance genes (sul1, sul2, sul3), tetracycline resistance genes (tetA, tetB, tet34), trimethoprim resistance genes (dfrA1, dfrA17, dfr14), quinolone resistance genes (qnrB1), and others.
Analysis of Antibiotic-Resistant and Virulence Genes of Enterococcus Detected in Calf Colostrum-One Health Perspective.
The study identified multiple antibiotic-resistant genes in Enterococcus isolates from bovine colostrum, including tet(K), tet(L), tet(M), erm(B), and ant(6)-Ia, which confer resistance to tetracycline, erythromycin, and streptomycin. High rates of multidrug resistance were observed.
Molecular Characterization of Staphylococcus aureus Isolated from Raw Milk and Humans in Eastern Tanzania: Genetic Diversity and Inter-Host Transmission.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from raw milk and humans in eastern Tanzania, including blaZ, dfrG, erm(C), tet(K), and str, which confer resistance to penicillin, trimethoprim, macrolides, tetracycline, and streptomycin, respectively.
ARGs Detection in Listeria Monocytogenes Strains Isolated from the Atlantic Salmon (Salmo salar) Food Industry: A Retrospective Study.
The study identified various AMR genes in L. monocytogenes strains from Atlantic salmon, including tetracycline resistance genes (tetC, tetD, tetK, tetL, tetS), aminoglycoside resistance genes (aadA, strA, aacC2, aphA1, aphA2), macrolide resistance genes (cmlA1, catI, catII), and oxazolidinone resistance genes (cfr, optrA, poxtA).
Antibacterial Activity of the Essential Oil of Piper tuberculatum Jacq. Fruits against Multidrug-Resistant Strains: Inhibition of Efflux Pumps and β-Lactamase.
The essential oil of Piper tuberculatum fruits inhibits β-lactamase and efflux pumps (NorA, Tet(K), and MepA) in multidrug-resistant Staphylococcus aureus strains, enhancing antibiotic activity.
Antimicrobial resistance and virulence profiles of staphylococci isolated from clinical bovine mastitis.
The study identified several AMR genes including blaZ, mecA, tetK, tetM, ermC, and ermB in Staphylococcus aureus and coagulase-negative staphylococci isolated from bovine mastitis. These genes conferred resistance to penicillin, methicillin, tetracycline, and erythromycin.
The Prevalence of the Virulence Genes of Staphylococcus aureus in Sickle Cell Disease Patients at KSUMC, Riyadh, Saudi Arabia.
The study identified the presence of several virulence genes and antibiotic resistance genes in clinical Staphylococcus aureus and MRSA isolates from SCD patients, including blaZ, mecA, tetK, and ermC.
Occurrence, Antibiotic Susceptibility, Biofilm Formation and Molecular Characterization of Staphylococcus aureus Isolated from Raw Shrimp in China.
The study identified multiple antibiotic resistance genes in Staphylococcus aureus isolates from raw shrimp in China, including mecA, mecR1, blaZ, aph(3')-IIIa, aad(6), ANT(4')-Ib, tet(K), mph(C), lnu(A), ermB, ermC, dfrC, dfrG, fosB, SAT-4, rpoB, msr(A), mepA, mepR, norA, mgrA, tet(38), sav1866, arlR, and arlS, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramins, trimethoprim, fosfomycin, and others.
Genomic Features of Antimicrobial Resistance in Staphylococcus pseudintermedius Isolated from Dogs with Pyoderma in Argentina and the United States: A Comparative Study.
The study identified various antimicrobial resistance genes and mutations in Staphylococcus pseudintermedius isolates from dogs in Argentina and the United States, highlighting differences in resistance profiles between the two regions.
Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin.
The study identified the presence of the tetracycline resistance gene tetK in Mammaliicoccus sciuri isolates, which was associated with tetracycline resistance. The gene was found on small plasmids, suggesting a potential mechanism for horizontal gene transfer.
Whole genome sequence-based analysis of Staphylococcus aureus isolated from bovine mastitis in Thuringia, Germany.
The study identified multiple AMR genes and mutations in Staphylococcus aureus isolates from bovine mastitis in Thuringia, Germany, including blaZ, blaI, blaR, blaPC, mecA, tetM, tetK, ermA, dfrG, dfrK, ant(6)-Ia, aac(6')-Ie-aph(2"), aadD1, ant(9)-Ia, ant(4')-Ia, aph(2")-Ih, gyrA_S84L, and parC_S80F/Y.
Genomic Insights into Methicillin-Resistant Staphylococci and Mammaliicocci from Bulk Tank Milk of Dairy Farms in Serbia.
The study identified multiple AMR genes in methicillin-resistant staphylococci and mammaliicocci from bulk tank milk, highlighting their role as potential reservoirs of antimicrobial resistance genes.
A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA).
The review highlights the role of PBP2a, encoded by the mecA gene, in conferring resistance to β-lactam antibiotics in MRSA. It also discusses the importance of β-lactamase enzymes, such as those encoded by blaZ, in degrading β-lactam antibiotics.
Valencene, Nootkatone and Their Liposomal Nanoformulations as Potential Inhibitors of NorA, Tet(K), MsrA, and MepA Efflux Pumps in Staphylococcus aureus Strains.
Valencene and nootkatone were identified as potential inhibitors of the NorA, Tet(K), MsrA, and MepA efflux pumps in Staphylococcus aureus strains, reducing the MIC of antibiotics and increasing EtBr fluorescence emission, indicating efflux pump inhibition.
Significant increase in the prevalence of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus, particularly the USA300 variant ΨUSA300, in the Japanese community.
The study found a significant increase in the prevalence of PVL-positive MRSA, particularly the USA300 variant ΨUSA300, in the Japanese community. ΨUSA300 was associated with deep-seated SSTIs and showed distinct antimicrobial resistance profiles compared to USA300.
Antimicrobial Resistance Genes in Staphylococcus Species Isolated from Diabetic Foot Ulcers and Healthy Skin
The study identified various antimicrobial resistance genes in Staphylococcus species isolated from diabetic foot ulcers and healthy skin, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, macrolides, tetracyclines, fusidic acid, trimethoprim-sulfamethoxazole, fosfomycin, kanamycin, neomycin, and quaternary ammonium compounds.
Investigation of antimicrobial susceptibility and genetic diversity among Staphylococcus pseudintermedius isolated from dogs in Rio de Janeiro.
The study identified 21 resistance determinants in MRSP and MSSP strains of Staphylococcus pseudintermedius, including genes such as blaZ, sdrM, norA, fosB, ykkcd, sepA, aac(6')-aph(2''), dfrG, aph(3')-III, ant(6)-Ia, sat4, erm(B), aad(6), tet(M), cat(pC221), qacG, tet(K), and qacJ, which confer resistance to various antimicrobials.
Antimicrobial Resistance Profiles of Staphylococcus Isolated from Cows with Subclinical Mastitis: Do Strains from the Environment and from Humans Contribute to the Dissemination of Resistance among Bacteria on Dairy Farms in Colombia?
The study identified several AMR genes in Staphylococcus isolates from dairy farms in Colombia, including blaZ, aacA-aphD, mecA, tetK, and ermC, which confer resistance to β-lactams, aminoglycosides, methicillin, tetracyclines, and macrolides, respectively.
Occurrence and Antimicrobial Resistance among Staphylococci Isolated from the Skin Microbiota of Healthy Goats and Sheep.
The study identified several antimicrobial resistance genes in staphylococci isolated from the skin microbiota of healthy goats and sheep, including mecA, blaZ, tetL, tetK, ermB, ermC, lnu, and grlA. These genes confer resistance to various antibiotics such as methicillin, penicillin, tetracycline, macrolides, lincosamides, and fluoroquinolones.
Comparative Antibacterial and Efflux Pump Inhibitory Activity of Isolated Nerolidol, Farnesol, and α-Bisabolol Sesquiterpenes and Their Liposomal Nanoformulations.
The study identified that the sesquiterpenes nerolidol, farnesol, and alpha-bisabolol inhibited efflux pumps NorA, Tet(K), MsrA, and MepA in Staphylococcus aureus strains, reducing the minimum inhibitory concentration (MIC) of antibiotics and enhancing their antibacterial activity.
Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of Staphylococcus saprophyticus.
The study identifies several AMR genes in Staphylococcus saprophyticus, including mecA, blaZ, erm, erm(44)v, msr(A), and mph(C), which confer resistance to beta-lactams, macrolides, and lincosamides. The presence of these genes is associated with varying levels of resistance, and some genes, like mecA, are useful markers for predicting resistance to specific antibiotics.
Shotgun Metagenomics-Guided Prediction Reveals the Metal Tolerance and Antibiotic Resistance of Microbes in Poly-Extreme Environments in the Danakil Depression, Afar Region.
The study identified numerous antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in the metagenomes of Lake Afdera and the Assale salt plain in the Danakil Depression. Key ARGs included beta-lactamases (ACC-1, OXA-58, OXA-363, OXA-212, NDM-17, OXA-134, ACT-29, LRA-19), efflux pumps (emrB, abeM, abeS, mgrA, adeJ, MexC, adeL, adeH), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet39, tetX, tetK), and others. MRGs included copper resistance genes (copC, copD), cadmium resistance gene (cadD), mercury resistance gene (merA), chromate resistance genes (chrB, chrA), nickel-cobalt-cadmium resistance genes (nccA, nccB), cobalt-zinc-cadmium resistance gene (czcD), arsenic resistance gene (arsO), lead resistance gene (pbrA), and mercury resistance genes (merB, merR, MIR).
Metagenomic identification of pathogens and antimicrobial-resistant genes in bacterial positive blood cultures by nanopore sequencing.
The study identified various antimicrobial resistance (AMR) genes in bacterial positive blood cultures using nanopore sequencing, demonstrating the effectiveness of this method in detecting resistance mechanisms and pathogens quickly.
Canine Staphylococcaceae circulating in a Kenyan animal shelter.
The study identified various AMR genes in Staphylococcaceae strains isolated from dogs in a Kenyan animal shelter, including tetracycline, beta-lactam, and aminoglycoside resistance genes.
Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis.
The study characterizes the resistome of Gram-positive bacteria causing keratitis, identifying several AMR genes and mutations associated with resistance to antibiotics such as macrolides, aminoglycosides, tetracyclines, and fluoroquinolones. Key findings include the prevalence of ermA, ermB, ermC, mphC, msrA, msrD, mecA, ant(9)-Ia, ant(4′)-Ib, aac(6′)-aph(2″), aph(3′)-III, fosB, tetK, tetM, dfrG, dfrC, and dfrE genes, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Virulence determinants and antibiotic resistance in staphylococci isolated from the skin of captive bred reptiles.
The study identified several AMR genes in staphylococci isolated from the skin of captive-bred reptiles, including blaZ, dfrK, dfrA(S1), tetK, msrA, mecA, and mecC. These genes conferred resistance to various antibiotics such as ampicillin, cefoxitin, trimethoprim, tetracycline, erythromycin, and cephalosporins. The study highlights the prevalence of multidrug resistance among these isolates.
Prevalence of virulence- and antibiotic resistance-associated genotypes and phenotypes in Staphylococcus aureus strains from the food sector compared to clinical and cow mastitis isolates.
The study identified various antibiotic resistance genes and mutations in Staphylococcus aureus strains from different sources, including beta-lactam resistance genes (blaZ, mecA), aminoglycoside resistance genes (ant(4')-Ia, aph(3')-Ia), tetracycline resistance genes (tetM, tetK), and the bleO gene for bleomycin resistance. Mutations in gyrA and grlA were also found to contribute to quinolone resistance.
Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen.
The study identified multiple antibiotic resistance genes in coagulase-negative staphylococci (CoNS) isolates from acne patients in Egypt, including blaZ, mecA, tet(K), erm(C), lnuA, vgaA, dfrC, fusB, fosBx1, norA, and vanT. These genes were found to be located on plasmids and chromosomes, indicating a multidrug-resistant profile.
A Comparative Phenotypic and Genomic Analysis of Methicillin-Resistant Staphylococcus aureus ST45 Isolates From Cellulitis and Osteomyelitis in Taiwan.
The study identified specific mutations and gene acquisitions in OM-MRSA ST45 isolates that confer resistance to fluoroquinolones, fusidic acid, gentamicin, and doxycycline, highlighting their increased pathogenicity and resistance mechanisms compared to CL-MRSA ST45 isolates.
Antimicrobial resistance and virulence profiling of Staphylococcus pseudintermedius isolated from cats, Bangladesh.
The study identified methicillin-resistant S. pseudintermedius (MRSP) with the mecA gene, erythromycin resistance genes ermA and ermB, and tetracycline resistance genes tetK and tetL in cats in Bangladesh.
Genetic Diversification and Resistome of Coagulase-Negative Staphylococci from Nostrils of Healthy Dogs and Dog-Owners in La Rioja, Spain.
The study identified various AMR genes including blaZ, mecA, erm(A), erm(C), erm(T), mph(C), msr(A), vga(A), lsaB, ant4′, aac6′-aph2″, tet(K), tet(M), dfrA, dfrG, catPC221, and mupA in CoNS isolates from healthy dogs and dog-owners. Additionally, a linezolid-resistant S. epidermidis isolate was found to have multiple amino acid substitutions in 50S ribosomal proteins L3 and L4.
Hybrid Illumina-Nanopore assembly improves identification of multilocus sequence types and antimicrobial resistance genes of Staphylococcus aureus isolated from Vermont dairy farms: comparison to Illumina-only and R9.4.1 nanopore-only assemblies.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from Vermont dairy farms, including beta-lactam resistance genes (blaZ, blaI, blaR), tetracycline resistance genes (tet(K), tet(38)), erythromycin resistance genes (erm(T), erm(A)), lincomycin resistance gene (lnu(G)), aminoglycoside resistance genes (aaC3, ant(9)-la), multidrug resistance efflux pumps (lmrS, mepA, mepR, mepB, norA, norB, arlS, arlR, mgrA), and fosfomycin resistance gene (fosB).
Alarming multidrug resistance in Staphylococcus aureus isolated from raw milk of cows with subclinical mastitis: Antibiotic resistance patterns and occurrence of selected resistance genes.
The study identified the presence of multidrug-resistant Staphylococcus aureus (MDR-S. aureus) and methicillin-resistant S. aureus (MRSA) strains in raw milk from cows with subclinical mastitis, carrying resistance genes blaZ, tetK, mecA, and aacA-aphD.
Detection of Salmonella Pathogenicity Islands and Antimicrobial-Resistant Genes in Salmonella enterica Serovars Enteritidis and Typhimurium Isolated from Broiler Chickens.
The study identified several antimicrobial-resistant genes in Salmonella enterica serovars Enteritidis and Typhimurium isolated from broiler chickens, including tet(K), tet(O), tet(A), mcr-1, mcr-4, strA, strB, aadA, aadE, sulI, ampC, TEM, CTX-M, and OXA. These genes conferred resistance to tetracycline, colistin, aminoglycosides, sulfonamides, and beta-lactam antibiotics.
Methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococcus produce antimicrobial substances against members of the skin microbiota in children with atopic dermatitis.
The study identified two bacteriocin gene clusters, aureocin 4181 in MRSA 23ad and epidermicin NI01 in S. epidermidis 84ad, which are involved in the production of antimicrobial substances that inhibit the growth of other staphylococcal species.
Antimicrobial resistance, enterotoxin and biofilm production genes in Staphylococcus spp. isolated from facilities and fomites in veterinary hospital in the Caatinga biome.
The study identified several antimicrobial resistance genes including blaZ, mecA, tetM, tetL, and tetK in Staphylococcus spp. isolates from a veterinary hospital in the Caatinga biome. Additionally, the icaD gene associated with biofilm production was detected in one S. sciuri strain.
Four novel Acinetobacter lwoffii strains isolated from the milk of cows in China with subclinical mastitis.
Four Acinetobacter lwoffii strains were isolated from the milk of cows with subclinical mastitis in China. These strains exhibited multidrug resistance and carried 17 resistance genes, including beta-lactamase, aminoglycoside-modifying, fluoroquinolone, tetracycline, sulfonamide, and chloramphenicol resistance genes.
Genetic Complexity of CC5 Staphylococcus aureus Isolates Associated with Sternal Bursitis in Chickens: Antimicrobial Resistance, Virulence, Plasmids, and Biofilm Formation.
The study identified multiple antimicrobial resistance genes in S. aureus isolates from sternal bursitis in chickens, including aph(3')-IIIa, tetK, tet38, ermC, parC, and fosB, which confer resistance to aminoglycosides, tetracyclines, macrolides, fluoroquinolones, and fosfomycin.
Displacement of Hospital-Acquired, Methicillin-Resistant Staphylococcus aureus Clones by Heterogeneous Community Strains in Kenya over a 13-Year Period.
The study identified several AMR genes and mutations in MRSA strains from Kenya, including aac(6')-aph(2''), dfrG, tetK, gyrA (S84L), and grlA (S80Y), indicating resistance to aminoglycosides, trimethoprim, tetracycline, and fluoroquinolones.
Emergence of novel methicillin resistant Staphylococcus pseudintermedius lineages revealed by whole genome sequencing of isolates from companion animals and humans in Scotland.
The study identified novel methicillin-resistant Staphylococcus pseudintermedius (MRSP) lineages, including ST726 and ST551, and characterized antimicrobial resistance genes such as mecA, blaZ, tetK, and mupA. It also noted a high prevalence of multidrug resistance (MDR) among MRSP isolates.
Mobile genetic element-driven genomic changes in a community-associated methicillin-resistant Staphylococcus aureus clone during its transmission in a regional community outbreak in Japan.
The study identified the blaZ gene as a determinant of penicillin resistance in the TDC clone of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) during a regional outbreak in Japan.
Investigation of antimicrobial resistance and antimicrobial resistance genes in Staphylococcus aureus and coagulase-negative staphylococci isolated from rabbit.
The study identified multiple antimicrobial resistance genes, including bla Z, aac A- aph D, msr A, tet K, gyr A, grl A, dfr G, and cfr, in Staphylococcus aureus and coagulase-negative staphylococci isolated from rabbit clinical abscesses, highlighting the presence of multidrug-resistant strains.
Antimicrobial Resistance in Pathogenic Staphylococci Causing Mastitis and Skin, Ear and Vaginal Infections in Animals
The study identified tetracycline resistance genes tetK and tetM in staphylococci isolated from animals in Uganda, with tetK being the most prevalent.
Genomic characterization of methicillin-resistant Staphylococcus aureus isolated from patients attending regional referral hospitals in Tanzania.
The study identifies the presence of various AMR genes in MRSA isolates from Tanzanian regional hospitals, including blaZ, erm(C), aac(6')-aph(2''), and tet(K). These genes contribute to resistance against beta-lactams, macrolides, aminoglycosides, and tetracyclines, highlighting the complexity of resistance profiles in MRSA.
Antimicrobial Resistance in Coagulase-Negative Staphylococci: Resistome, Mobiloome, and Relatedness
The study identifies multiple AMR genes and mutations in CoNS isolates from various hosts, highlighting the spread of multidrug resistance and the role of mobile genetic elements in the dissemination of resistance traits.
Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome.
The study found that doxy-PEP use over 6 months significantly increased the proportion and expression of tetracycline resistance genes in the gut microbiome, with no significant changes in other antibiotic resistance gene classes.
Prevalence of pathogens and antimicrobial resistance of isolated Staphylococcus spp. in bovine mastitis milk in South Korea, 2018-2022.
The study identified several antimicrobial resistance genes in Staphylococcus spp. isolated from bovine mastitis milk, including mecA, blaZ, tetK, ermC, lnuA, and lnuB. These genes were associated with resistance to penicillins, tetracyclines, erythromycin, and lincomycin.
Desiccation tolerance and reduced antibiotic resistance: Key drivers in ST239-III to ST22-IV MRSA clonal replacement at a Malaysian teaching hospital.
The study identifies AMR genes and mutations associated with the clonal replacement of MRSA strains in a Malaysian hospital, highlighting the role of desiccation tolerance and reduced antibiotic resistance.
Detection and genetic characterization of multidrug-resistant staphylococci isolated from public areas in an international airport.
The study identified multiple multidrug-resistant staphylococci, including methicillin-resistant S. haemolyticus, S. epidermidis, and a livestock-associated MRSA (LA-MRSA) strain, carrying various resistance genes such as mecA, blaZ, erm(C), aac(6')-aph(2''), and others, highlighting the presence of AMR in public environments.
Whole genome sequencing revealed high proportions of ST152 MRSA among clinical Staphylococcus aureus isolates from ten hospitals in Ghana.
The study identified high proportions of ST152 MRSA among clinical S. aureus isolates in Ghana, with blaZ, mecA, cat, tetK, and dfrG being the most prevalent resistance genes.
Methicillin-Resistant S. aureus Carrying the PVL and Toxic Shock Syndrome Toxin in Healthy Dogs in Algeria.
The study identified methicillin-resistant S. aureus (MRSA) in healthy dogs in Algeria, with isolates carrying the mecA gene and other resistance genes such as blaZ, ant(6)-Ia, aph(3')-III, erm(C), and tet(K). Some isolates also harbored the PVL and tst genes encoding virulence factors.
Microbial spectrum and resistance of odontogenic abscesses - microbiological analysis using next generation sequencing.
The study identified multiple AMR genes in odontogenic abscesses using NGS, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, chloramphenicol, sulfonamides, penicillins, and others. Notably, Fusobacterium showed resistance to clindamycin.
Deciphering pathogenicity and virulence of the first Staphylococcus debuckii isolate from diabetic foot osteomyelitis.
The study characterizes the first Staphylococcus debuckii isolate from diabetic foot osteomyelitis, identifying genes associated with virulence and resistance, including tetK, ebpS, qacA/qacR, czcD, norA, mdeA, and sdrM.
The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials.
The study identified several AMR genes in Staphylococcus hominis, including erm(C), tetK, acc(6')-Ie aph(2''), aph(3')-IIIa, ant(4')-Ia, msr(B), mph(C), lnu(A), and vga, which confer resistance to various antibiotics such as macrolides, lincosamides, streptogramins, tetracyclines, and aminoglycosides. The majority of the strains exhibited multidrug resistance.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Known mechanisms cannot account for a third of reduced susceptibility in non-aureus staphylococci.
Mapping Antimicrobial Resistance in Staphylococcus epidermidis Isolates from Subclinical Mastitis in Danish Dairy Cows.
The study identified several antimicrobial resistance genes in Staphylococcus epidermidis isolates from subclinical mastitis in Danish dairy cows, including blaZ for penicillin resistance, fosB for fosfomycin resistance, msr(A) and mph(C) for erythromycin resistance, and tet(K) for tetracycline resistance.
The Difference a Year Can Make: How Antibiotic Resistance Mechanisms in Pseudomonas aeruginosa Have Changed in Northwestern Transylvania.
The study identified an increase in multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates in Northwestern Transylvania, Romania, between 2022 and 2023. Key AMR genes included bla OXA-50, sul1, ermB, mexA, mexB, bla VIM-1, aac(6′)-II, ant(4′)-Ia, aac(3)-I, aac(6′)-Im, aph(2″)-Ib, tetA, tetC, tetK, qnrB, ermC, mphC, fosA, nfsA, nfsB, ampC, and TEM-1.
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
The study identified various AMR genes and mutations in Salmonella Enteritidis isolates from Spain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and aminoglycoside resistance genes. Chromosomal mutations in the gyrA gene were also found to contribute to quinolone resistance.
Characteristic profiles of molecular types, antibiotic resistance, antibiotic resistance genes, and virulence genes of Staphylococcus aureus isolates from caprine mastitis in China.
The study identified several AMR genes in S. aureus isolates from caprine mastitis in China, including blaZ, mecA, tetK, tetM, ermB, lnu(B), aacA-aphD, and gyrA, which confer resistance to various antibiotics such as penicillin, oxacillin, tetracycline, erythromycin, lincomycin, gentamicin, amikacin, and fluoroquinolones.
Study on molecular characteristics of Staphylococcus from yak milk-Xizang.
The study identified several AMR genes in Staphylococcus isolates from yak milk, including blaZ, mecA, gyrA, glrB, gyrB, lnuA, tetK, aacA-aphD, vga, and ermC, which confer resistance to various antibiotics such as penicillin, methicillin, tetracycline, and aminoglycosides.
Effect of Sub-Inhibitory Concentrations of Quaternary Ammonium Compounds and Heavy Metals on Antibiotic Resistance and Expression of Virulence Factors Among Staphylococcus spp. from Dairy Products.
Sub-inhibitory concentrations of benzalkonium chloride and cadmium chloride induce the overexpression of antibiotic resistance genes such as bla Z, erm B, mec A, tet K, and tet M in Staphylococcus isolates from dairy products, leading to increased antibiotic resistance.
Impact of the Technical Snow Production Process on Bacterial Community Composition, Antibacterial Resistance Genes, and Antibiotic Input-A Dual Effect of the Inevitable.
The study identified several antibiotic resistance genes (ARGs) in water and snow samples from ski resorts, including blaTEM, blaCTX-M, mecA, ereA, ermB, strA, tetK, and sulIII. These genes were associated with resistance to beta-lactams, macrolides, aminoglycosides, tetracyclines, and sulfonamides. The presence of these ARGs highlights the potential environmental impact of technical snow production on antimicrobial resistance.
Bats as Hosts of Antimicrobial-Resistant Mammaliicoccus lentus and Staphylococcus epidermidis with Zoonotic Relevance.
The study identified antimicrobial resistance genes in Mammaliicoccus lentus and Staphylococcus epidermidis isolated from bats, including mph(C), msr(A), dfrC, salB, tet(K), str, qacA, arsB, and cadD, highlighting their potential for horizontal gene transfer and environmental co-selection.
Wild Birds as Drivers of Salmonella Braenderup and Multidrug Resistant Bacteria in Wetlands of Northern Italy.
The study identifies several AMR genes in bacterial isolates from wild aquatic birds in Northern Italy, including beta-lactamases (blaTEM, blaCMY-1, blaCMY-2, blaNDM, blaKPC), colistin resistance genes (mcr-2, mcr-3, mcr-4), tetracycline resistance genes (tetA, tetB, tetC, tetL, tetM, tetK), macrolide resistance genes (ermB, vatD, vgA, msrC), vancomycin resistance genes (vanC1, vanC2, vanM, vanG), sulfonamide resistance genes (sul1, sul2, sul3), aminoglycoside resistance genes (aac(3), aac(6')-Ib, aph(3')-Ia, armA, rmtB, rmtC, rmtF), and nitrofurantoin resistance genes (nfsA, nfsB).
Phylogenomic associations among methicillin-resistant Staphylococcus aureus isolates derived from pets, dairies, and humans.
The study identified several AMR genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates from pets, dairies, and humans, including mecA, tet(M), tet(K), erm(C), erm(A), mph(C), msr(A), blaR1, blaZ, blaI_of_Z, blaPC1, vga(A), fosB-Saur, sat4, bleO, ant(9)-Ia, aph(2'')-Ih, aph(3')-IIIa, and ant(4')-Ia. These genes confer resistance to various antibiotics such as methicillin, tetracycline, erythromycin, macrolides, lincomycin, fosfomycin, streptothricin, bleomycin, spectinomycin, amikacin, gentamicin, kanamycin, tobramycin, and others.
Antimicrobial resistance and molecular characteristics of bovine mastitis-associated methicillin-resistant Staphylococcus aureus: potential for cross-species transmission of ST59-MRSA.
The study identified several antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates from bovine mastitis, including erm(B), erm(C), tet(L), tet(K), mecA, fexA, aac(6')-aph(2''), ant(4')-Ia, ant(6)-Ia, and aph(2'')-Ia. These genes were associated with resistance to various antibiotics such as erythromycin, tetracycline, penicillin, oxacillin, cefoxitin, florfenicol, and gentamicin.
The characteristics of methicillin-resistant Staphylococcus aureus co-infection in COVID-19 pneumonia.
The study identified several antimicrobial resistance genes in MRSA isolates from patients with COVID-19 pneumonia and MRSA pneumonia without COVID-19, including aac(6')-aph(2''), aph(2'')-Ia, aph(3')-III, aadD, ermA, ermB, ermC, tetM, tetK, mupA, and tst. No significant differences in antimicrobial resistance genes were observed between the two groups.
Genomic characterisation of nasal isolates of coagulase-negative Staphylococci from healthy medical students reveals novel Staphylococcal cassette chromosome mec elements.
The study identified novel Staphylococcal cassette chromosome mec (SCC mec ) elements in four methicillin-resistant coagulase-negative Staphylococci (CoNS) isolates from healthy medical students. The isolates harbored various antimicrobial resistance genes, including mecA, blaZ, mphC, msrA, tetK, fusC, fusF, qacA, qacB, qacC, norA, copB, arsC, cadC, cadD, copZ, copA, copR, and czcD, which conferred resistance to beta-lactams, macrolides, tetracyclines, fusidic acid, quaternary ammonium compounds, fluoroquinolones, and heavy metals.
Emergence of livestock-associated MRSA in the Egyptian Nile Delta that carry the exfoliative toxin gene etA: a case for enhanced surveillance.
The study identifies a novel variant of a CC15 livestock-associated MRSA strain from Egypt that carries the exfoliative toxin gene etA, highlighting potential increased virulence and the need for enhanced surveillance.
Application of MALDI-TOF MS and FT-IR spectroscopy in identification and antibiotic resistance profiling of lactic acid bacteria.
The study demonstrates the correlation between FT-IR spectral profiles and antibiotic resistance in lactic acid bacteria, highlighting the utility of these techniques for rapid resistance detection.
A cross-sectional molecular epidemiological study of biofilm-producing methicillin-resistant Staphylococcus aureus.
The study identified multiple antimicrobial resistance genes, including mecA, vanA, vanB, ermE, tetK, and icaA, in biofilm-producing methicillin-resistant Staphylococcus aureus isolates. These genes were associated with resistance to various antibiotics and biofilm formation.
Prevalence and antimicrobial resistance of methicillin-resistant and methicillin-susceptible Staphylococcus in small- to medium-scale and large-scale dairy farms in Thailand.
The study identified several AMR genes and mutations in Staphylococcus isolates from small- to medium-scale and large-scale dairy farms in Thailand, highlighting differences in resistance profiles between farm types.
Prevalence, species identification, and antibiotic resistance of Staphylococci in dogs visiting veterinary clinics in Vietnam.
The study identified several antibiotic resistance genes in Staphylococcus isolates from dogs in Vietnam, including aacA-aphD, tetK, gyrA, mecA, msrA, dfrA, and ermA, highlighting the prevalence of multidrug-resistant Staphylococcus species.
Prevalence, toxin virulence genes and investigating the effect of mutations in the tetracycline gene (tetK) on the response of methicillin-resistant Staphylococcus aureus to antibiotics: a study in sickle cell disease patients in Riyadh, Saudi Arabia.
The study identified the tetracycline resistance gene tetK in MRSA isolates from SCD patients in Riyadh, Saudi Arabia, and detected several mutations in the tetK gene that correlate with altered antibiotic susceptibility.
Isolation and Molecular Characterization of Three Staphylococcus pseudintermedius Strains from Dogs and Humans in Egypt.
Three Staphylococcus pseudintermedius isolates from dogs and humans in Egypt were characterized. The isolates showed resistance to various antibiotics, including penicillin, tetracycline, aminoglycosides, chloramphenicol, fusidic acid, macrolides, streptothricin, and trimethoprim. None of the isolates carried the mecA gene, which is associated with methicillin resistance.
An NGS-assisted diagnostic workflow for culture-independent detection of bloodstream pathogens and prediction of antimicrobial resistances in sepsis.
The study evaluated the diagnostic performance of PISTE™ technology, an NGS-based workflow for detecting bloodstream pathogens and predicting antimicrobial resistance. It showed high accuracy in identifying pathogens and predicting resistance genes, including beta-lactamases, carbapenemases, aminoglycoside modifying enzymes, tetracycline efflux pumps, and quinolone resistance proteins.
Molecular Epidemiology, Antimicrobial Resistance, and Virulence Profiles of Staphylococcus aureus from Fish, Aquatic Environments, and Fish Handlers in Southeast Nigeria.
The study identified 19 antimicrobial resistance genes in Staphylococcus aureus isolates from fish, aquatic environments, and fish handlers in Southeast Nigeria, highlighting the presence of multidrug-resistant strains with various resistance mechanisms.
Molecular identification of antibiotic-resistant and virulent Escherichia coli and Staphylococcus aureus isolated from dogs in Southern Benin.
The study identified several antibiotic resistance genes in Escherichia coli and Staphylococcus aureus isolated from dogs in Southern Benin, including blaTEM, tetA, strA-strB, tetK, tetM, and blaZ, which confer resistance to penicillin, tetracycline, and streptomycin.
Hemolytic activity and antibiotic resistance profiles of Staphylococcus aureus isolates from clinical patients.
The study identified the presence of antibiotic resistance genes accA-aphD, tetK, and tetM in Staphylococcus aureus isolates, which confer resistance to gentamicin, tetracycline, and doxycycline. These genes were detected in both MRSA and MSSA isolates, with varying prevalence depending on the isolate type.
Zoonotic potential of methicillin-resistant Staphylococcus aureus isolated from pets and their owners in Bangladesh.
The study identified methicillin-resistant Staphylococcus aureus (MRSA) in pets and their owners in Bangladesh, highlighting the zoonotic potential of MRSA. Key AMR genes included mecA, tetA, tetK, tet(38), and blaZ, which conferred resistance to methicillin, tetracycline, and penicillin.
Whole genome sequence of multidrug-resistant Staphylococcus haemolyticus and Enterococcus faecalis isolates from public gymnasium equipment reveals evolving infection potential and resistance.
The study identified multiple antibiotic resistance genes in multidrug-resistant Staphylococcus haemolyticus and Enterococcus faecalis isolates from public gymnasium equipment, highlighting their potential to resist various antibiotics and posing a health risk in communal environments.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Bovine mastitis and antimicrobial resistance in Pakistan's dairy sector: current status and future prospects.
The paper highlights the high prevalence of bovine mastitis in Pakistan, particularly caused by Staphylococcus aureus, and discusses the growing concern of antimicrobial resistance (AMR) due to the frequent and often inappropriate use of antibiotics in mastitis management.
Genomic diversity and antimicrobial resistance of Staphylococcus aureus in Saudi Arabia: a nationwide study using whole-genome sequencing.
The study identified multiple AMR genes in S. aureus isolates from Saudi Arabia, highlighting the genetic diversity and resistance patterns associated with mass gatherings. Key genes include mecA, mecR1, aacA-aphD, knt, tet(K), ermC, msrA, fcl_1, natA, macB, and dppB, which confer resistance to various antibiotics.
Prevalence and antimicrobial resistance characterization of multidrug-resistant Staphylococcus epidermidis isolated from raw milk of dairy cattle and ewes.
The study identified the presence of multidrug-resistant Staphylococcus epidermidis in raw milk samples from dairy cattle and ewes, with high prevalence of resistance genes mecA, tetK, and ermC.
Molecular epidemiology and geographical variation of methicillin-resistant Staphylococcus aureus: a multicentre study across Xinjiang, China.
The study identified several AMR genes in MRSA isolates from Xinjiang, China, including blaZ, ermB, aph(3')-III, aac(6')-aph(2''), ermC, tetM, and tetK, which confer resistance to various antibiotics such as penicillin, oxacillin, erythromycin, clindamycin, kanamycin, tetracycline, and gentamicin.
Antimicrobial Resistance in Staphylococcus aureus at the Human-Animal-Environment Interface in East Africa: A Systematic Review and Meta-Analysis
The study identified key resistance genes including mecA, blaZ, tet(K), and erm(C) in Staphylococcus aureus isolates from East Africa, highlighting the prevalence of methicillin-resistant and multidrug-resistant strains.
Molecular Epidemiology, Clinical Manifestations, Decolonization Strategies, and Treatment Options of Methicillin-Susceptible Staphylococcus Aureus Infection in Neonates.
The study identifies key antimicrobial resistance genes in methicillin-susceptible Staphylococcus aureus (MSSA) isolates, including blaZ, erm(C), and tet(K), which confer resistance to penicillin, macrolides, and tetracycline respectively. These findings highlight the complexity of antimicrobial resistance in MSSA and the need for continued surveillance and tailored antimicrobial stewardship.
Genomic characterization of Staphylococcus aureus isolated from mastitis in small ruminants in Sardinia, Italy.
The study identified erm(T), tet(K), and tet(M) as the primary AMR genes in S. aureus isolates from mastitis in Sardinia, with low resistance rates to erythromycin and tetracycline.
Antimicrobial resistance and virulence gene profiles of Enterococcus faecalis and Enterococcus faecium isolated from subclinical bovine mastitis milk and cow dung.
The study identified vanA, tetM, ermB, vanB, and tetK as the main antimicrobial resistance genes in Enterococcus faecalis and Enterococcus faecium isolates from subclinical bovine mastitis milk and cow dung samples.
Emergence of Multidrug-Resistant and Biofilm-Producing Staphylococcus aureus from Raw Poultry in Algeria: Implications for Public Health.
The study identified several AMR genes in S. aureus isolates from raw poultry in Algeria, including blaZ, mecA, tet(M), tet(K), tet(S), erm(B), and erm(C). These genes were associated with resistance to penicillin, methicillin, tetracycline, and erythromycin.
Efflux pump-associated antimicrobial resistance genes in Staphylococcus spp. from dairy and meat samples.
The study identified several efflux pump-associated antimicrobial resistance genes in Staphylococcus spp. from dairy and meat samples, including smr, efrA, efrB, mdeA, norE, tetK, bla, and mecA. These genes were found to confer resistance to tetracycline, cefuroxime, and ampicillin.
Complete nucleotide sequence of pT181, a tetracycline-resistance plasmid from Staphylococcus aureus.
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