Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline efflux MFS transporter Tet(L)
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G155S | - | - | Escherichia coli | tetracycline | Reslit | Candidate |
| P156A | - | - | Escherichia coli | tetracycline | Reslit | Candidate |
| P156C | - | - | Escherichia coli | tetracycline | Reslit | Candidate |
| P156G | - | - | Escherichia coli | tetracycline | Reslit | Candidate |
| - | - | Escherichia coli | tetracycline | Reslit | Candidate | |
| - | - | Escherichia coli | tetracycline | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Tet(L) | Card DatabaseReference Gene CatalogReslit | 121 | TETRACYCLINE, tetracycline +5 | Bacillus subtilis +103 | Europe, Ireland, Spain, United States, China, Vietnam, United States|USA, United States|U.S.|France|Korea, Gulf of Gdansk|Vistula River, Korea, Japan, Canada, Nsukka agricultural zone, Nigeria, Poland, Germany|Egypt|Brazil|Chile|Vietnam|Russia|Belarus|Thailand, Europe|Spain, Thailand, USA|France|Portugal|China|Brazil|Germany|Sweden|Italy|Spain|Denmark|Japan|Korea|Europe|Asia|North America, Portugal, Chile, South Brazil, Germany, Denmark, Alberta, Canada, Bangladesh, GA, USA, South Africa, North America|Europe, Portugal|Spain|The Netherlands, Asia|Europe|Americas|China|Taiwan, Netherlands, United States|Germany, Malaysia, Bangladesh|South Africa|Nigeria|Pakistan|Ethiopia|USA|UK, Alberta, Northern Ghana, Tunisia, Europe|United States|Asia, Minnesota, Chiang Mai province, Northern Thailand|Thailand, Algiers|Algeria, France, Russia, Shenzhen, China, France|United States|Germany|Belgium|Poland, Japan|Denmark|Norway|China|United States|Switzerland|India|Netherlands, Saskatchewan, central China, Quebec, Canada, India, Ghana, Germany|Vietnam, Norway, Switzerland, Belgium, Turkey, Spain|Portugal|Germany|UK|Switzerland|Thailand|Italy, Iran, Brazil, China|Germany, Europe|UK, Europe|Norway|Romania | 1985, 1986, 1988, 1992, 2002, 2003, 2004, 2006, 2007, 2008, 2009, 2010, 2011, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | D12567.1 | BAA02119.1 |
| tet(L) | Card DatabaseResFinder Database | 2 | TETRACYCLINE, DOXYCYCLINE, MINOCYCLINE +2 | Geobacillus stearothermophilus +1 | - | 2011 | M11036.1 | AAA22851.1 |
| tetL | Reslit | 91 | tetracycline, doxycycline +3 | Staphylococcus aureus +78 | Europe|North America|Asia, United States|Japan|Canada|Spain|New Zealand|Denmark|U.S.|U.K.|Boston, China|Vietnam, Spain, Maine|New Hampshire, United States|Switzerland|Czech Republic|New Zealand, South Korea, Europe, Vietnam, Australia, Great Britain, Turkey, Southern Alberta, Canada, China, Chile, Poland, Egypt, International Space Station, New Zealand, Scotland|Australia|England, Mexico City, India, wastewater treatment plants|Canada, North West Province, South Africa, South Africa, Ethiopia, Brazilian Pampa biome|Brazil, Japan, United States, Portugal, Thailand|Denmark|Malaysia|China|Australia|United Kingdom|United States|Sweden|Singapore|France|Germany|Gabon|Israel|Japan, Malaysia, Bangladesh, Saudi Arabia, Germany, Alberta, Zambia, Brazil, Canada|United Kingdom|Alberta, Romania|Cluj County, North Western Romania, Korea, Ghana, Belgium, Edo, Nigeria, Northern Pacific Ocean|Norway Sea|Europe, Atlantic salmon, Swiss Canton Tessin|various herds|Switzerland, Caatinga biome, Latvia, Türkiye, Europe|Africa|North America|South America|Asia|Oceania, Uganda, Northern Italy, Australia|Czech Republic|Italy|New Zealand, Hong Kong, Peninsular Malaysia|Malaysia | 2003, 2007, 2009, 2010, 2011, 2012, 2014, 2015, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AY081910 | - |
| tet L | Reslit | 2 | tetracycline | Arthrobacter protophormiae +3 | Yangzhou City, South Africa | 2018, 2021 | KX981212|KX981438|KY048431|KY048441 | - |
| TETL-01 | Reslit | 1 | tetracycline | - | - | 2021 | PRJNA705824 | - |
| tet(L ) | Reslit | 1 | tetracycline | Enterococcus faecium +2 | Portugal | 2025 | KT862784|MH746818|CP161870|CP161865|CP161871|CP161866 | - |
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Tetracycline Induces Stabilization of mRNA in Bacillus subtilis.
The study shows that tetracycline induces stabilization of tet(L) mRNA in Bacillus subtilis, contributing to tetracycline resistance. Additionally, tetracycline stabilizes other mRNAs, indicating a broader effect on mRNA stability.
Influence of transferable genetic determinants on the outcome of typing methods commonly used for Enterococcus faecium.
The study identifies the tetL gene as a tetracycline resistance determinant in Enterococcus faecium, demonstrating its role in conferring resistance through efflux mechanisms.
Influence of transferable genetic determinants on the outcome of typing methods commonly used for Enterococcus faecium.
Prevalence and molecular characterization of tetracycline resistance in Enterococcus isolates from food.
The study identified tet(M), tet(L), and tet(S) genes as the primary tetracycline resistance mechanisms in Enterococcus isolates from food, with tet(M) being the most prevalent.
Antibiotic Resistance and Virulence Traits of Enterococci Isolated from Baylough, an Irish Artisanal Cheese
The study identified tetracycline resistance genes (tet(M) and tet(L)) and an erythromycin resistance gene (erm(B)) in Enterococcus strains isolated from an Irish artisanal cheese.
Nucleotide sequence and phylogeny of the tet(L) tetracycline resistance determinant encoded by plasmid pSTE1 from Staphylococcus hyicus.
Nucleotide sequence and phylogeny of the tet(L) tetracycline resistance determinant encoded by plasmid pSTE1 from Staphylococcus hyicus.
Distribution of Tetracycline Resistance Genes in Actinobacillus pleuropneumoniae Isolates from Spain.
The study identified tet(B), tet(O), tet(H), and tet(L) genes in Actinobacillus pleuropneumoniae isolates from Spain, all of which confer tetracycline resistance through efflux mechanisms.
Genetic diversity among Enterococcus faecalis.
The study identifies various AMR genes in Enterococcus faecalis, including blaZ, ermB, tetM, and vanA, which confer resistance to beta-lactams, macrolides, tetracyclines, and glycopeptides, respectively.
Evaluating the effects of chlortetracycline on the proliferation of antibiotic-resistant bacteria in a simulated river water ecosystem.
The study found that high concentrations of chlortetracycline (CTC) selected for increased tetracycline resistance in aerobic bacterial populations, with a greater diversity of tet resistance genes detected in the high-CTC chemostat compared to low-CTC and control chemostats.
Mosaic Tetracycline Resistance Genes and Their Flanking Regions in Bifidobacterium thermophilum and Lactobacillus johnsonii.
The study identifies mosaic tetracycline resistance genes, including tet(W/32/O) and tet(O/W/32/O/W/O) in Bifidobacterium thermophilum and Lactobacillus johnsonii, as well as a third determinant, tet(L), in B. thermophilum.
Two different tetracycline resistance mechanisms, plasmid-carried tet(L) and chromosomally located transposon-associated tet(M), coexist in Lactobacillus sakei Rits 9.
Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.
The study identifies various genes in Streptococcus suis strains that are associated with virulence and potential drug resistance, highlighting the genomic diversity and evolution of this pathogen.
Efflux-mediated drug resistance in bacteria: an update.
The paper provides an updated overview of drug efflux pumps in bacteria, focusing on their structure, mechanisms, and roles in multidrug resistance. It highlights the importance of RND, MFS, MATE, SMR, and ABC transporters in efflux-mediated resistance.
Skin lesion caused by ST398 and ST1 MRSA, Spain.
The study identifies multiple antimicrobial resistance genes and mutations in MRSA strains causing a skin lesion in a Spanish patient, including mecA, tetK, tetL, tetM, ermA, ermB, ermC, msrA, aph(2')-acc(6'), ant(4')-Ia, aph(3')-III, and dfrK, along with quinolone resistance mutations in grlA and gyrA.
Antibiotic resistance characteristics of environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river.
The study identified multiple tetracycline resistance genes (tet(A), tet(W), tet(C), tet(J), tet(L), tet(D), tet(Y), and tet(K)) in environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river, highlighting the widespread dissemination of these genes in aquatic environments exposed to high levels of antibiotic residues.
Tetracycline Resistance-Encoding Plasmid from Bacillus sp. Strain #24, Isolated from the Marine Sponge Haliclona simulans.
The study reports the first tetracycline resistance-encoding plasmid, pBHS24, from a marine sponge-associated bacterium, Bacillus sp. strain #24, which confers tetracycline resistance through the tet(L) gene.
Tetracycline resistance-encoding plasmid from Bacillus sp. strain #24, isolated from the marine sponge Haliclona simulans.
Tetracycline resistance-encoding plasmid from Bacillus sp. strain #24, isolated from the marine sponge Haliclona simulans., Identification and analysis of genes for tetracycline resistance and replication functions in the broad-host-range plasmid pLS1., Nucleotide sequence of the tetracycline resistance gene of pTHT15, a thermophilic Bacillus plasmid: comparison with staphylococcal TcR controls., Nucleotide sequence homology of the tetracycline-resistance determinant naturally maintained in Bacillus subtilis Marburg 168 chromosome and the tetracycline-resistance gene of B. subtilis plasmid pNS1981., Nucleotide sequence and phylogeny of the tet(L) tetracycline resistance determinant encoded by plasmid pSTE1 from Staphylococcus hyicus., Influence of transferable genetic determinants on the outcome of typing methods commonly used for Enterococcus faecium., Novel Tet(L) Efflux Pump Variants Conferring Resistance to Tigecycline and Eravacycline in Staphylococcus Spp.
The antimicrobial resistance patterns and associated determinants in Streptococcus suis isolated from humans in southern Vietnam, 1997-2008.
The study reports the presence and expression of tet(L) in Streptococcus suis strains and highlights the co-expression of multiple tetracycline resistance genes contributing to high MIC levels against tetracycline.
Slaughterhouse pigs are a major reservoir of Streptococcus suis serotype 2 capable of causing human infection in southern Vietnam.
The study identified tetracycline resistance genes tet(M), tet(O), and tet(L), and erythromycin resistance gene erm(B) in Streptococcus suis serotype 2 strains isolated from slaughterhouse pigs in southern Vietnam.
The gut as reservoir of antibiotic resistance: microbial diversity of tetracycline resistance in mother and infant.
The study identified various tetracycline resistance genes, including tet(M), tet(L), erm(T), tet(W), tet(O), and tet(X), in the gut microbiota of a mother and her infant. It also discovered a novel composite transposon, Tn 6079, carrying tet(M), tet(L), and erm(T) in the infant's gut, highlighting the potential for horizontal gene transfer and maternal transmission of antibiotic resistance.
Persistent, toxin-antitoxin system-independent, tetracycline resistance-encoding plasmid from a dairy Enterococcus faecium isolate.
The study identifies the tetracycline resistance genes tet(M) and tet(L) on a 19.6-kb plasmid from a dairy Enterococcus faecium isolate, demonstrating their functionality and transmissibility.
Complete genome and comparative analysis of Streptococcus gallolyticus subsp. gallolyticus, an emerging pathogen of infective endocarditis.
The study identified tetracycline resistance genes tetL and tet(O/W/32/O) in the plasmid pSGG1 of Streptococcus gallolyticus subsp. gallolyticus strain BAA-2069, highlighting the role of plasmids in lateral gene transfer and tetracycline resistance.
Functional metagenomics reveals previously unrecognized diversity of antibiotic resistance genes in gulls.
The study identified numerous antibiotic resistance (AR) genes in gulls, including both known and previously undescribed ones. It highlights the significant diversity of AR genes in gulls, emphasizing their potential role in spreading resistance genes between human and environmental habitats.
Long-term exposure to antibiotics has caused accumulation of resistance determinants in the gut microbiota of honeybees.
The study identifies eight tetracycline resistance genes (tetB, tetC, tetD, tetH, tetL, tetY, tetM, and tetW) in the gut microbiota of honeybees, highlighting the accumulation of resistance determinants due to long-term antibiotic exposure in beekeeping practices.
Novel erm(T)-carrying multiresistance plasmids from porcine and human isolates of methicillin-resistant Staphylococcus aureus ST398 that also harbor cadmium and copper resistance determinants.
The study identifies novel erm(T)-carrying multiresistance plasmids from porcine and human isolates of methicillin-resistant Staphylococcus aureus ST398, which also harbor cadmium and copper resistance determinants.
Genetic mechanisms of antimicrobial resistance identified in Salmonella enterica, Escherichia coli, and Enteroccocus spp. isolated from U.S. food animals.
The study identifies various AMR genes in Salmonella enterica, Escherichia coli, and Enterococcus spp. isolated from U.S. food animals, including aac(3'), aac(6'), aadA, aadA1, aadA2, aadA12, aphAI, aph(3')-Ii-iv, strA, strB, bla CMY-2, bla TEM-1, bla PSE-1, floR, cmlA, cat1, cat2, sul1, sul2, dfr1, dfrA10, tet(A), tet(B), tet(C), tet(D), tet(G), and tetR.
Previously Undescribed Plasmids Recovered from Activated Sludge Confer Tetracycline Resistance and Phenotypic Changes to Acinetobacter oleivorans DR1.
The study identifies three previously undescribed tetracycline resistance plasmids (pAST1, pAST2, pAST3) and one previously reported plasmid (pAST4) from activated sludge, which confer tetracycline resistance in Acinetobacter oleivorans DR1.
Identification and analysis of genes for tetracycline resistance and replication functions in the broad-host-range plasmid pLS1.
Drug-resistant and hospital-associated Enterococcus faecium from wastewater, riverine estuary and anthropogenically impacted marine catchment basin.
The study identified multiple AMR genes in Enterococcus faecium isolates from wastewater, marine outfalls, and river environments, including pbp5, aac(6')-Ie-aph(2"), ant(6')-Ia, tet(M), and tet(L). Mutations in gyrA (S84R) were associated with ciprofloxacin resistance.
Transfer of tetracycline resistance genes with aggregation substance in food-borne Enterococcus faecalis.
The study identified the presence of tet(L), tet(M), and tet(S) genes in food-borne Enterococcus faecalis isolates, highlighting their role in tetracycline resistance and the potential for horizontal gene transfer via aggregation substances and pheromone-mediated conjugation.
Unraveling antimicrobial resistance genes and phenotype patterns among Enterococcus faecalis isolated from retail chicken products in Japan.
The study identified several antimicrobial resistance genes in Enterococcus faecalis isolated from retail chicken products in Japan, including aac(6')-Ie-aph(2")-Ia, aph(3')-IIIa, ant(6)-Ia, tet(L), tet(M), tet(O), and erm(B). These genes were associated with resistance to various antibiotics such as kanamycin, gentamicin, streptomycin, dihydrostreptomycin, oxytetracycline, and erythromycin.
Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis.
The study identifies several AMR genes, including aac(6')-aph(2")-Ia, vanA, vanB, tetM, ermB, aph(3')-IIIa, and sat4, which are associated with resistance to aminoglycosides, glycopeptides, tetracyclines, macrolides, lincosamides, streptogramin B, and streptothricin in Enterococcus faecium and Enterococcus faecalis.
Effect of in-feed administration and withdrawal of tylosin phosphate on antibiotic resistance in enterococci isolated from feedlot steers.
The study found that tylosin phosphate administration increased the proportion of erythromycin and tylosin resistant enterococci, but withdrawal reduced their prevalence. The resistance was primarily mediated by the erm(B) gene and msrC gene.
Identification and Antimicrobial Resistance of Bacteria Isolated from Probiotic Products Used in Shrimp Culture.
The study identified several antimicrobial resistance genes in Bacillus spp. isolated from probiotic products used in shrimp culture, including ermD (macrolide resistance), tetL (tetracycline resistance), fexA (phenicol resistance), and dfrD, dfrG, dfrK (trimethoprim resistance). These genes were detected through whole genome sequencing of multiple antimicrobial-resistant Bacillus isolates.
Characterization of mannitol-fermenting methicillin-resistant staphylococci isolated from pigs in Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant staphylococci isolated from pigs in Nigeria, including mecA, blaZ, erm(C), erm(B), str, tet(K), tet(M), tet(L), dfrG, dfrK, aacA/aphD, aphA3, cat pC221, and cat pC223. Additionally, a Ser84Leu mutation in the gyrA gene was found to confer ciprofloxacin resistance.
Prevalence of plasmid-mediated multidrug resistance determinants in fluoroquinolone-resistant bacteria isolated from sewage and surface water.
The study identified several plasmid-mediated resistance genes in fluoroquinolone-resistant bacteria, including aac(6')-Ib-cr, qnrS, qnrD, oqx A, blaTEM, blaOXA, blaCTX-M, blaSHV, tet(A), tet(K), tet(L), and tet(S). These genes were found to confer resistance to fluoroquinolones, beta-lactams, and tetracyclines.
Variety of Antimicrobial Resistances and Virulence Factors in Staphylococcus aureus Isolates from Meat Products Legally and Illegally Introduced to Germany.
The study identified multiple antimicrobial resistance genes and mutations in Staphylococcus aureus isolates from meat products, including resistance to β-lactams, macrolides, aminoglycosides, tetracyclines, and others.
Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.).
The study identified various AMR genes and mutations in Enterococcus faecalis isolates from macaque cephalic implants, highlighting the presence of high-level aminoglycoside resistance, tetracycline resistance, and bacitracin resistance. These findings emphasize the complexity of AMR in clinical settings and the need for targeted antimicrobial strategies.
Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.).
The study identified various AMR genes and mutations in Enterococcus faecalis isolates from macaque cephalic implants, highlighting the presence of high-level aminoglycoside resistance, tetracycline resistance, and bacitracin resistance. These findings emphasize the complexity of AMR in clinical settings and the need for targeted antimicrobial strategies.
Interspecies transfer of vancomycin, erythromycin and tetracycline resistance among Enterococcus species recovered from agrarian sources.
The study identified the transfer of vancomycin, erythromycin, and tetracycline resistance genes among Enterococcus species, highlighting the potential for horizontal gene transfer in agrarian environments.
Comparative genomics of Enterococcus spp. isolated from bovine feces.
The study identified several antibiotic resistance genes in Enterococcus spp. isolated from bovine feces, including erm(B) for macrolide-lincosamide-streptogramin B resistance, tet(L), tet(M), and tet(O) for tetracycline resistance, and the vanC operon for glycopeptide resistance.
Nucleotide sequence homology of the tetracycline-resistance determinant naturally maintained in Bacillus subtilis Marburg 168 chromosome and the tetracycline-resistance gene of B. subtilis plasmid pNS1981.
A Functional Metagenomic Analysis of Tetracycline Resistance in Cheese Bacteria.
The study identified four tetracycline resistance genes (tet(A), tet(L), tet(M), and tet(S)) in cheese bacteria using functional metagenomics.
Evolution of the Staphylococcus argenteus ST2250 Clone in Northeastern Thailand Is Linked with the Acquisition of Livestock-Associated Staphylococcal Genes.
The study identifies the tetracycline resistance gene tet(L) as a significant contributor to the antimicrobial resistance profile of the S. argenteus ST2250 clone, highlighting its association with livestock-associated S. aureus.
Transmission of highly virulent community-associated MRSA ST93 and livestock-associated MRSA ST398 between humans and pigs in Australia.
The study identified the presence of CA-MRSA ST93-IV and LA-MRSA ST398-V in Australian pigs, farm workers, and the environment. It also reported the first linezolid-resistant MRSA isolate in Australia. Resistance mechanisms included genes such as blaZ, ermC, fexA, tetK, tetL, vgaA, lnuB, aadD, aadE, and cfr.
Assessment of antibiotic susceptibility in Lactobacillus isolates from chickens.
The study identified several tetracycline, macrolide, and aminoglycoside resistance genes in Lactobacillus isolates from chickens, highlighting the presence of resistance mechanisms in these bacteria.
mcr-1 and mcr-2 variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015.
The study identifies mcr-1.10 and mcr-2.2 variant genes in Moraxella species isolated from pigs in Great Britain, along with eptA, which confer resistance to colistin. Additionally, bla BRO-1 and tetL genes were found to confer resistance to ampicillin and tetracycline respectively.
Detection of Antibiotic Resistance and Resistance Genes in Enterococci Isolated from Sucuk, a Traditional Turkish Dry-Fermented Sausage.
The study identified several AMR genes including ermB, ermC, gyrA, tetM, tetL, and vanA in Enterococcus isolates from Sucuk, highlighting the potential for these bacteria to serve as reservoirs of antibiotic resistance genes.
Subtype-Specific Selection for Resistance to Fluoroquinolones but Not to Tetracyclines Is Evident in Campylobacter jejuni Isolates from Beef Cattle in Confined Feeding Operations in Southern Alberta, Canada.
The study identifies tetO as the primary tetracycline resistance gene in Campylobacter jejuni isolates from beef cattle and highlights gyrA mutations, particularly Thr86Ile, as a major cause of fluoroquinolone resistance.
High diversity and abundance of cultivable tetracycline-resistant bacteria in soil following pig manure application.
The study identifies several tetracycline resistance genes (tet B, tet L, tet Z, tet M, tet O, and tet X) in cultivable tetracycline-resistant bacteria from pig manure and soil, highlighting the diversity and abundance of these genes following pig manure application.
Antimicrobial Resistance in Streptococcus spp.
The paper discusses the prevalence and mechanisms of antimicrobial resistance in Streptococcus species, particularly focusing on macrolide, lincosamide, and tetracycline resistance. Key genes identified include erm(B), erm(A), lnuB, lnuD, mefA, mefE, msr, tet(B), tet(K), tet(L), tet(M), tet(O), and tet(S).
Increasing macrolide resistance among Streptococcus agalactiae causing invasive disease in non-pregnant adults was driven by a single capsular-transformed lineage, Portugal, 2009 to 2015.
The study identifies a significant increase in macrolide resistance among Streptococcus agalactiae isolates causing invasive disease in non-pregnant adults in Portugal, primarily linked to the expansion of a specific capsular-transformed lineage (CC1) harboring resistance genes such as erm(B), erm(TR), erm(T), mef(E), tet(M), tet(O), and tet(L).
Combination Therapy Strategies Against Multiple-Resistant Streptococcus Suis.
The study identifies several AMR genes in multidrug-resistant Streptococcus suis isolates, including tetM, lnuB, erm(B), tetO, tetL, and aph3′, which confer resistance to tetracycline, clindamycin, erythromycin, and aminoglycosides.
The draft genomes and investigation of serotype distribution, antimicrobial resistance of group B Streptococcus strains isolated from urine in Suzhou, China.
The study identified several AMR genes in GBS isolates from urine in Suzhou, including tetM, ermB, mefE, lnuB, and others, associated with resistance to tetracycline, erythromycin, clindamycin, and fluoroquinolones.
Current Status of the Use of Antibiotics and the Antimicrobial Resistance in the Chilean Salmon Farms.
The study identifies several AMR genes, including floR, tet(A), tet(B), tet(H), tet(l), tet(34), tet(35), aac(6')-Ib-cr, and intI1, associated with resistance to florfenicol, oxytetracycline, quinolones, and kanamycin in Chilean salmon farming environments.
Nucleotide sequence of the tetracycline resistance gene of pTHT15, a thermophilic Bacillus plasmid: comparison with staphylococcal TcR controls.
Nucleotide sequence of the tetracycline resistance gene of pTHT15, a thermophilic Bacillus plasmid: comparison with staphylococcal TcR controls.
Antimicrobial Susceptibility Testing and Tentative Epidemiological Cutoff Values for Five Bacillus Species Relevant for Use as Animal Feed Additives or for Plant Protection.
The study identified several antimicrobial resistance genes in five Bacillus species, including a putative chloramphenicol acetyltransferase (cat) gene in Bacillus megaterium, a tetracycline efflux gene (tet(L)) in Bacillus velezensis and Bacillus amyloliquefaciens, and an erythromycin resistance gene (ermD) in Bacillus paralicheniformis and Bacillus licheniformis.
Antibiotic resistance gene dynamics in the gut microbiota following amoxicillin-clavulanic acid treatment
The study identified several AMR genes, including aminoglycoside resistance genes (ksgA, strA, strB), beta-lactam resistance genes (blaCARB-4, blaCMY-1, blaCMY-2, blaCTX-M-1, blaCTX-M-12, blaDHA-1, blaOXA-1, blaSHV-1, blaSHV-37, blaSHV-3, blaTEM-1A, blaTEM-1B), and tetracycline resistance genes (tetA, tetB, tetC, tetK, tetL), that were enriched in the gut microbiota of healthy adults following amoxicillin-clavulanic acid treatment.
Extended antibiotic treatment in salmon farms select multiresistant gut bacteria with a high prevalence of antibiotic resistance genes.
The study identifies several AMR genes, including floR, fexA, and various tetracycline resistance genes (tetA, tetB, tetE, tetH, tetL, tetM, tet34, tet35), associated with resistance to florfenicol and oxytetracycline in gut bacteria from salmon farms. These genes were found in multiple bacterial species, highlighting the widespread nature of AMR in aquatic environments.
Antimicrobial Resistance Profiles in Enterococcus spp. Isolates From Fecal Samples of Wild and Captive Black Capuchin Monkeys (Sapajus nigritus) in South Brazil.
The study identified the presence of antimicrobial resistance genes msrC, tet(M), and tet(L) in Enterococcus spp. isolates from wild and captive black capuchin monkeys in South Brazil, indicating the spread of resistance mechanisms in these bacterial populations.
Antimicrobial Resistance in Lactobacillus Species: A Genomic and Phenotypic Analysis
The study identifies various tetracycline, erythromycin, chloramphenicol, and aminoglycoside resistance genes in Lactobacillus species, highlighting their potential role in antimicrobial resistance and horizontal gene transfer.
Identification and antibiotic susceptibility of lactobacilli isolated from turkeys.
The study identified several tetracycline, macrolide, and lincosamide resistance genes in turkey-derived lactobacilli, including tetL, tetM, tetW, ermB, ermC, lnuA, aadE, ant(6)-Ia, cat, and lsaE. These genes were associated with resistance to tetracycline, erythromycin, lincomycin, streptomycin, chloramphenicol, and tiamulin.
Characterization of a new transferable MDR plasmid carrying the pbp5 gene from a clade B commensal Enterococcus faecium.
Draft Genome Sequence of an Enterococcus faecalis Strain (24FS) That Was Isolated from Healthy Infant Feces and Exhibits High Antibacterial Activity, Multiple-Antibiotic Resistance, and Multiple Virulence Factors.
The study reports the draft genome sequence of Enterococcus faecalis 24FS, highlighting its multiple-antibiotic resistance traits, including resistance to chloramphenicol, tetracycline, erythromycin, aminoglycosides, fluoroquinolones, trimethoprim, streptothricin, and streptomycin, along with potential virulence factors.
Biofilm Forming Antibiotic Resistant Gram-Positive Pathogens Isolated From Surfaces on the International Space Station.
The study identified several AMR genes including ermC, tetK, aac6-aph2a, aph(2)-ic, aadD, aph3-III, and ermB in Gram-positive pathogens isolated from the International Space Station. These genes conferred resistance to erythromycin, tetracycline, gentamicin, kanamycin, and other antibiotics.
Agricultural Origins of a Highly Persistent Lineage of Vancomycin-Resistant Enterococcus faecalis in New Zealand.
The study identifies the ST108 lineage of vancomycin-resistant Enterococcus faecalis as having an agricultural origin, with multiple resistance genes including vanA, ermB, tetL, tetM, and bcr operon components contributing to its persistence in New Zealand.
Emergence of multidrug resistance and extensive drug resistance among enterococcal clinical isolates in Egypt.
The study identified several AMR genes in enterococcal isolates, including aac(6')-Ie-aph(2'')-Ia, ant(6')-Ia, ermB, msrA/B, tetK, tetL, tetM, vanB, vanC1, and optrA, which confer resistance to various antibiotics such as gentamicin, streptomycin, macrolides, lincosamides, tetracyclines, vancomycin, and linezolid.
Emergence of an Australian-like pstS-null vancomycin resistant Enterococcus faecium clone in Scotland.
The study identifies multiple AMR genes in Scottish vancomycin-resistant Enterococcus faecium (VREfm) isolates, including aac(6')-Ii, aac(6')-aph(2''), ermB, pbp5-R, vanA, ant(9)-Ia, tetL, and dfrG. These genes confer resistance to various antibiotics, highlighting the multidrug-resistant nature of the isolates.
Detection of Antibiotic Resistance and Classical Enterotoxin Genes in Coagulase-negative Staphylococci Isolated from Poultry in Poland.
The study identified several AMR genes in coagulase-negative Staphylococcus (CNS) isolates from poultry in Poland, including blaZ, mecA, tetK, tetL, ermA, ermB, aac(6')-Ie-aph(2'')-Ia, msrA/B, and cfr. These genes conferred resistance to various antibiotics such as beta-lactams, methicillin, tetracyclines, macrolides, lincosamides, streptogramin B, aminoglycosides, phenicols, oxazolidinones, pleuromutilins, and streptogramin A.
Characteristics of methicillin-resistant Staphylococcus aureus from broiler farms in Germany are rather lineage- than source-specific.
The study identified multiple AMR genes in MRSA isolates from German broiler farms, including tet(K), tet(L), tet(M), erm(B), vga(A), dfrK, spc, and cat(pC221), which confer resistance to tetracycline, MLS B antibiotics, tiamulin, trimethoprim, spectinomycin, and chloramphenicol, respectively.
Microbiological and clinical characteristics of Streptococcus gallolyticus subsp. pasteurianus infection in China.
The study characterizes the AMR genes and mutations in Streptococcus gallolyticus subsp. pasteurianus isolates from China, identifying erm(B), erm(A), erm(T), mef(A/E), tet(L), tet(O), and tet(M) as major contributors to erythromycin, clindamycin, and tetracycline resistance.
Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility.
The study identifies several AMR genes and mutations associated with reduced oxacillin susceptibility in equine Staphylococcus aureus isolates, including blaZ, aadD, dfrG, tet(L), and aacA-aphD, along with various mutations in genes such as FemA, FemB, FemX, CcpA, GdpP, and PBP1-4.
Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children's Hospital in México City in an eight-years survey.
The study identifies various AMR genes and mutations in multidrug-resistant Staphylococcus epidermidis strains isolated from a children's hospital in Mexico City, highlighting the presence of genes such as blaZ, mecA, and others, as well as mutations in gyrA and rpoB contributing to resistance.
Antibiotic Susceptibility, Virulence Pattern, and Typing of Staphylococcus aureus Strains Isolated From Variety of Infections in India.
The study identified various AMR genes in S. aureus isolates, including mecA, pvl, czrC, qacA/B, aac(6')/aph(2), aph(3'-III), msrA, ermA, ermC, mphC, tetK, tetL, tetM, cat::pC221, cat::pC223, cat::pC194, dfrA, dfrB, and dfrG, which confer resistance to multiple antibiotics such as oxacillin, chloramphenicol, gentamicin, erythromycin, clindamycin, tetracycline, and trimethoprim.
Antimicrobial Resistance and Virulence Gene Profiles of Methicillin-Resistant and -Susceptible Staphylococcus aureus From Food Products in Denmark.
The study identified several antimicrobial resistance genes, including blaZ, tet(K), tet(L), tet(M), and various erm genes, in Staphylococcus aureus isolates from food products in Denmark. Additionally, the tst gene was detected in CC398 and CC45 isolates, indicating the presence of toxic shock syndrome toxin.
Comparative genomics of multidrug-resistant Enterococcus spp. isolated from wastewater treatment plants.
The study identified several AMR genes in multidrug-resistant Enterococcus spp. isolated from wastewater treatment plants, including vancomycin resistance genes (vanA, vanM, vanG, vanC), macrolide resistance genes (ermB, msrC), tetracycline resistance genes (tetL), aminoglycoside resistance genes (aad(6'), aac(6')-Ie-aph(2")-Ia, ant(9')-Ia, aph(3')-IIIa, SAT-4, ant(6')-Ia), chloramphenicol resistance gene (cat), dihydrofolate reductase genes (dfrE, dfrF, dfrG), and lincosamide resistance genes (InuB, InuG).
In Vitro Pharmacodynamic Analyses Help Guide the Treatment of Multidrug-Resistant Enterococcus faecium and Carbapenem-Resistant Enterobacter cloacae Bacteremia in a Liver Transplant Patient.
The study identifies various AMR genes and mutations in Enterococcus faecium and Enterobacter hormaechei isolates from a liver transplant patient, highlighting their roles in resistance to multiple antibiotics.
Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum.
The study identified several AMR genes in Enterococcus spp., including erm(B), tet(M), optrA, dfrE, lsa(A), aac(6')-Ib, eat(A), ant(6)-Ia, aph(3')-IIIa, sat4, tet(L), bcrB, bcrC, dfrF, and dfrG, which confer resistance to various antibiotics such as macrolides, tetracyclines, oxazolidinones, trimethoprim, and aminoglycosides.
Investigation of a Reduction in Tylosin on the Prevalence of Liver Abscesses and Antimicrobial Resistance in Enterococci in Feedlot Cattle.
The study identified several AMR genes in enterococci isolated from feedlot cattle, including erm(B), msr(C), tet(L), tet(M), and tet(O), which confer resistance to macrolides and tetracyclines.
Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report.
Genotypic and Phenotypic Evaluation of Biofilm Production and Antimicrobial Resistance in Staphylococcus aureus Isolated from Milk, North West Province, South Africa.
The study identified several antimicrobial resistance genes, including blaZ, vanB, tetK, tetL, and msrA/B, in Staphylococcus aureus isolates from milk. These genes were associated with resistance to penicillin, vancomycin, tetracycline, and macrolides. Additionally, biofilm-forming genes icaA, icaB, icaC, icaD, and bap were detected, highlighting the potential public health risk posed by these isolates.
Detection of a Novel, and Likely Ancestral, Tn916-Like Element from a Human Saliva Metagenomic Library.
The study identified a novel Tn916-like element from a human saliva metagenomic library, which encodes the tetracycline resistance genes tet(M) and tet(L).
Characterization of Staphylococci and Streptococci Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified multiple AMR genes in Staphylococcus and Streptococcus isolates from bovine milk, including blaZ, mecA, erm(C), aac(aph)D, tetK, tetL, tetM, lnuA, erm(A), erm(B), aphA-3, aad-6, and optrA, indicating widespread resistance to beta-lactams, macrolides, aminoglycosides, tetracyclines, and linezolid.
Simultaneous Nasal Carriage by Methicillin-Resistant and Methicillin Susceptible Staphylococcus aureus of Lineage ST398 in a Live Pig Transporter.
The study characterizes two S. aureus ST398 strains, one methicillin-resistant (MRSA) and one methicillin-susceptible (MSSA), isolated from a pig transporter. The MRSA strain harbors the mecA gene, while the MSSA strain lacks it due to a large deletion. Both strains exhibit resistance to several antibiotics including tetracycline, lincosamides, aminoglycosides, and trimethoprim.
Identification of Selected Antibiotic Resistance Genes in Two Different Wastewater Treatment Plant Systems in Poland: A Preliminary Study.
The study identified the presence of tetracycline resistance genes (tet(B), tet(K), tet(L), tet(O)) and the sulfonamide resistance gene sulIII in wastewater treatment plant samples. These genes were detected in both raw influent and final effluent samples, indicating their persistence through the treatment process.
Antimicrobial Resistance, Virulence Genes, and Biofilm Formation Capacity Among Enterococcus species From Yaks in Aba Tibetan Autonomous Prefecture, China.
The study identified multiple antimicrobial resistance (AMR) genes in Enterococcus species isolated from yaks, including ermA, ermB, tetA, tetB, tetM, tetL, cat, optrA, and poxtA. These genes conferred resistance to various antibiotics such as erythromycin, tetracycline, chloramphenicol, and linezolid. Additionally, a high prevalence of multidrug-resistant (MDR) Enterococcus strains was observed.
Antibiotic Resistance-Susceptibility Profiles of Enterococcus faecalis and Streptococcus spp. From the Human Vagina, and Genome Analysis of the Genetic Basis of Intrinsic and Acquired Resistances.
The study identified tetracycline resistance genes tet(M) and tet(L) in Enterococcus faecalis and Streptococcus anginosus, and the lsaA gene associated with resistance to clindamycin and quinupristin-dalfopristin in E. faecalis. These genes were validated through PCR, genome sequencing, and functional analysis.
Drug Resistance Determinants in Clinical Isolates of Enterococcus faecalis in Bangladesh: Identification of Oxazolidinone Resistance Gene optrA in ST59 and ST902 Lineages.
The study identified the oxazolidinone resistance gene optrA in Enterococcus faecalis isolates from Bangladesh, along with other resistance genes such as erm(B), aac(6')-Ie-aph(2'')-Ia, tet(M), and tet(L). Mutations in gyrA and parC were associated with levofloxacin resistance.
Antimicrobial Resistance Gene Detection and Plasmid Typing Among Multidrug Resistant Enterococci Isolated from Freshwater Environment.
The study identified twelve antimicrobial resistance genes in multidrug-resistant Enterococcus isolates from freshwater, including genes conferring resistance to tetracycline, erythromycin, tylosin, kanamycin, streptomycin, and ciprofloxacin. These genes were detected through PCR and sequencing, highlighting the diversity of resistance mechanisms in environmental Enterococcus.
Emergence of a Novel tet(L) Variant in Campylobacter spp. of Chicken Origin in China.
A novel tet(L) variant was identified in Campylobacter spp. of chicken origin, which confers resistance to tetracycline, doxycycline, and tigecycline through an efflux mechanism.
Complete Genomic Analysis of VRE From a Cattle Feedlot: Focus on 2 Antibiotic Resistance.
The study identified multiple antibiotic resistance genes in vancomycin-resistant enterococci (VRE) isolates from a cattle feedlot, including vanC1, vanC2/C3, vanXY-C, VanR, macA, macB, rlmA (II), erm(A), aac(6')-la, blaEC, tet(A), tet(L), S10p, gyrA, gyrB, msbA, S12p, rpoB, mdfA/cmr, liaF, liaR, liaS, bcrC, mprF, pgsA, ef-G, ef-TU, ddl, alr, kasA, isotRNA, inhA, fabl, murA, folA, and Dfr, which confer resistance to various antibiotics such as vancomycin, macrolides, aminoglycosides, β-lactams, tetracyclines, quinolones, and others.
Complete Genomic Analysis of VRE From a Cattle Feedlot: Focus on 2 Antibiotic Resistance.
The study identified multiple antibiotic resistance genes in vancomycin-resistant enterococci (VRE) isolates from a cattle feedlot, including vanC1, vanC2/C3, vanXY-C, VanR, macA, macB, rlmA (II), erm(A), aac(6')-la, blaEC, tet(A), tet(L), S10p, gyrA, gyrB, msbA, S12p, rpoB, mdfA/cmr, liaF, liaR, liaS, bcrC, mprF, pgsA, ef-G, ef-TU, ddl, alr, kasA, isotRNA, inhA, fabl, murA, folA, and Dfr, which confer resistance to various antibiotics such as vancomycin, macrolides, aminoglycosides, β-lactams, tetracyclines, quinolones, and others.
Features of Streptococcus agalactiae strains recovered from pregnant women and newborns attending different hospitals in Ethiopia.
The study identified tetracycline resistance genes tetM, tetL, and tetO, macrolide/lincosamide resistance genes ermTR, ermB, and lnu, and aminoglycoside resistance gene aac(6')-Ib in Streptococcus agalactiae isolates. Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
Species Distribution, Antimicrobial Resistance, and Enterotoxigenicity of Non-aureus Staphylococci in Retail Chicken Meat.
The study identified tetracycline resistance genes tet(L) and tet(K) in non-aureus staphylococci (NAS) from retail chicken meat, and mutations in the quinolone resistance determining regions (QRDR) of gyrA and parC contributing to fluoroquinolone resistance in S. agnetis and S. chromogenes.
In Vitro Activity of the Novel Tetracyclines, Tigecycline, Eravacycline, and Omadacycline, Against Moraxella catarrhalis.
The study identified tetB and tetL genes as tetracycline resistance genes in Moraxella catarrhalis. Mutations in the 16S rRNA genes (C1036T and/or G460A) were associated with omadacycline resistance.
Use of Oral Tetracyclines in the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia: A Literature Review on the Often-Overlooked Antibiotic Class.
The review highlights the mechanisms of resistance to tetracyclines, including efflux pumps (tet(K), tet(L), tet(B)), ribosomal protection proteins (tet(M)), and enzymatic deactivation (tet(X)). These genes confer resistance to tetracycline, doxycycline, minocycline, and omadacycline in various bacterial pathogens.
Multidrug Resistance in Enterococci Isolated From Wild Pampas Foxes (Lycalopex gymnocercus) and Geoffroy's Cats (Leopardus geoffroyi) in the Brazilian Pampa Biome.
The study identified multidrug-resistant Enterococcus strains in wild Pampas foxes and Geoffroy's cats, with resistance genes ermB, msrC, tetL, and tetM detected in erythromycin and tetracycline-resistant isolates.
Characterization of Enterococci- and ESBL-Producing Escherichia coli Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified several AMR genes in Enterococcus and ESBL-producing E. coli isolates from bovine mastitis cases in Egypt, including erm(B), tetL, aac-aphD, vanA, and vanB.
A Preliminary Study: Antibiotic Resistance of Escherichia coli and Staphylococcus aureus from the Meat and Feces of Various South African Wildlife Species.
The study identified antibiotic resistance genes in Escherichia coli and Staphylococcus aureus from wildlife meat and feces, including blaCMY, aadA, sul1, sul2, tetA, tetB, tetK, tetL, tetM, vanA, vanB, and blaZ, which conferred resistance to ampicillin, streptomycin, sulfonamides, tetracycline, vancomycin, and penicillin.
Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era.
The study identifies several antimicrobial resistance genes in old Enterococcus faecalis isolates, including tet(L), cat, erm(B), aac(6')-aph(2''), aadD, drfC, and ble, demonstrating the early emergence of antimicrobial resistance traits in this species.
Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureus.
The paper discusses the mechanisms of antibiotic resistance in methicillin-resistant Staphylococcus aureus (MRSA), focusing on genes such as blaZ, mecA, and dltA, which are involved in beta-lactam and glycopeptide resistance. It highlights the importance of understanding these resistance mechanisms to develop new therapeutic strategies.
Antimicrobial Resistance Genes in Bacteria Isolated From Japanese Honey, and Their Potential for Conferring Macrolide and Lincosamide Resistance in the American Foulbrood Pathogen Paenibacillus larvae.
The study identified the ermC gene on the plasmid pJ18TS1mac and the lsaB and oleC genes on an integrative conjugative element (ICE) in honey-derived bacteria, which conferred resistance to tylosin and lincomycin in Paenibacillus larvae. Additionally, the ermL and ermB genes on plasmid pJ45TS6 were found to contribute to macrolide resistance.
Chicken Manure and Mushroom Residues Affect Soil Bacterial Community Structure but Not the Bacterial Resistome When Applied at the Same Rate of Nitrogen for 3 Years.
The study identified several antibiotic resistance genes (ARGs) in chicken manure, mushroom residues, and heat-treated chicken manure, highlighting the impact of different organic manures on the soil resistome. Key findings include the enrichment of specific ARGs such as aadE, aadD, qacE1, qacH, lnuA, vatE, and tetL in soils treated with various manures, indicating the potential for ARG transfer through manure application.
Effects of Ursolic Acid on Intestinal Health and Gut Bacteria Antibiotic Resistance in Mice.
Ursolic acid reduced the expression of tetracycline resistance genes in the gut microbiota of antibiotic-exposed mice.
Molecular Evolution and Adaptation of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) Sequence Type 9.
The study identifies multiple AMR genes and mutations in ST9 S. aureus, including mecA, blaZ, lnu(B), lsa(E), erm(C), fexA, tet(L), dfrG, vwb, and the MDR ST9 element, highlighting their role in multidrug resistance and host adaptation.
Analysis of Virulence and Antimicrobial Resistance Gene Carriage in Staphylococcus aureus Infections in Equids Using Whole-Genome Sequencing.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from equids, including blaZ, mupA, lnuA, tetK, tetL, tetM, norA, dfrC, dfrG, dfrK, ermA, ermC, msrA, mphC, qacA/B, qacC, and fosB. An isolate (17-021) was found to carry the lnuA gene and mupA plasmid, conferring resistance to clindamycin and mupirocin. A mutation in the prs gene was associated with phenotypic susceptibility to β-lactam drugs in a mecA-positive isolate.
Misidentification of meticillin-resistant Staphylococcus aureus by the Cepheid Xpert MRSA NxG assay, the Netherlands, February to March 2021.
The study reports two false-negative results in detecting meticillin-resistant Staphylococcus aureus (MRSA) using the Cepheid Xpert MRSA NxG assay. The isolates were resistant to multiple antibiotics, including beta-lactams, aminoglycosides, and tetracyclines, and carried resistance genes such as blaZ, mecA, erm(T), aac(6')-aph(2"), tet(L), and tet(M).
Epidemiology of Staphylococcus pseudintermedius in cats in Poland.
The study characterized the antibiotic resistance profiles of Staphylococcus pseudintermedius isolates from cats in Poland, identifying several resistance genes including blaZ, mecA, aac(6')Ie-aph(2")Ia, ermB, tet(L), and tet(M).
Danofloxacin Treatment Alters the Diversity and Resistome Profile of Gut Microbiota in Calves.
Danofloxacin treatment altered the gut microbiota diversity and resistome profile in calves, increasing the frequency and host range of several antimicrobial resistance genes (ARGs) such as aac(6')-Ib, ant9, tet40, tetW, ermF, tetL, and tetX.
Evaluation of Tetracycline Resistance and Determination of the Tentative Microbiological Cutoff Values in Lactic Acid Bacterial Species.
The study identified five tetracycline resistance genes (tet(M), tet(W/N/W), tet(L), tet(S), and tet(45)) in lactic acid bacteria (LAB) and determined species-specific microbiological cutoff values for tetracycline resistance.
Prediction of Antimicrobial Resistance in Clinical Enterococcus faecium Isolates Using a Rules-Based Analysis of Whole-Genome Sequences.
The study identified several AMR genes and mutations in Enterococcus faecium isolates, including pbp5, vanA, vanB, aac(6')-Ie-aph(2")-Ia, gyrA, parC, tet(L), tet(M), tet(S), and 23S rRNA. These genes and mutations were validated experimentally and showed high accuracy in predicting antimicrobial resistance.
Distribution and Clonal Diversity of Staphylococcus aureus and Other Staphylococci in Surface Waters: Detection of ST425-t742 and ST130-t843 mecC-Positive MRSA Strains.
The study identified mecC-positive MRSA strains ST425-t742 and ST130-t843 in surface waters, along with various AMR genes such as mecC, blaZ, ermT, msr(A/B), vgaA, tetL, mecA, mph(C), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, dfrA, fusB, and catpC221 in Staphylococcus aureus and coagulase-negative staphylococci.
Novel Tet(L) Efflux Pump Variants Conferring Resistance to Tigecycline and Eravacycline in Staphylococcus Spp.
The study identifies two novel tet(L) gene variants, tet(L) F58L and tet(L) A117V, which confer resistance to tigecycline and eravacycline in Staphylococcus spp.
Genomic Analysis of Global Staphylococcus argenteus Strains Reveals Distinct Lineages With Differing Virulence and Antibiotic Resistance Gene Content.
The study identifies several antibiotic resistance genes in Staphylococcus argenteus, including blaZ, mecA, and fosB, which confer resistance to penicillin, methicillin, and fosfomycin, respectively. These genes were found in different lineages and geographic regions.
Detection, molecular characterization, and antibiogram of multi-drug resistant and methicillin-resistant Staphylococcus aureus (MRSA) isolated from pets and pet owners in Malaysia.
The study identified multiple AMR genes including mecA, tetK, tetL, ermA, ermB, ermC, msrA, scn, chp, sak, sea, and sep in S. aureus isolates from pets and pet owners in Malaysia, indicating the presence of multidrug-resistant and methicillin-resistant strains.
Whole genome sequence analyses-based assessment of virulence potential and antimicrobial susceptibilities and resistance of Enterococcus faecium strains isolated from commercial swine and cattle probiotic products.
The study identified several antimicrobial resistance (AMR) genes in Enterococcus faecium strains isolated from commercial swine and cattle probiotics, including aac(6')-Ii, aph(3')-III, ant(6)-Ia, tet(L), tet(M), msrC, and cat-(pc194). These genes confer resistance to aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramin B, and phenicols.
Comparative Analysis of Bacillus cereus Group Isolates' Resistance Using Disk Diffusion and Broth Microdilution and the Correlation between Antimicrobial Resistance Phenotypes and Genotypes.
The study identified several antimicrobial resistance genes in Bacillus cereus group isolates, including beta-lactamase-encoding genes (bla1, blaZ, blaTEM), mph for erythromycin resistance, rph for rifampicin resistance, and fosB for fosfomycin resistance. These genes were detected using ABRIcate and MEGARes 2.0 database, and their association with resistance phenotypes was analyzed.
Frequently used therapeutic antimicrobials and their resistance patterns on Staphylococcus aureus and Escherichia coli in mastitis affected lactating cows.
The study identified several antimicrobial resistance genes in Staphylococcus aureus and Escherichia coli isolated from mastitis-affected cows, including mecA, tetK, tetL, tetA, tetB, sul1, and sul2. These genes confer resistance to various antibiotics such as tetracycline, sulfamethoxazole-trimethoprim, and methicillin.
Multidrug-Resistant Methicillin-Resistant Coagulase-Negative Staphylococci in Healthy Poultry Slaughtered for Human Consumption.
The study identified multiple multidrug-resistant methicillin-resistant coagulase-negative staphylococci (MRCoNS) in poultry, carrying genes such as mecA, ermA, ermB, ermC, mphC, aph(3')-IIIa, ant(4')-Ia, str, tetK, tetL, tetM, tetO, cfr, dfrK, dfrD, and cat p194, which confer resistance to various antibiotics.
A One Health Approach Molecular Analysis of Staphylococcus aureus Reveals Distinct Lineages in Isolates from Miranda Donkeys (Equus asinus) and Their Handlers.
The study identified various antimicrobial resistance genes in Staphylococcus aureus and coagulase-negative staphylococci (CoNS) isolates from Miranda donkeys and their handlers, including blaZ, aph(3')-IIIa, tetK, tetL, tetM, lnuA, ermB, ermC, mecA, and optrA. These genes confer resistance to penicillins, aminoglycosides, tetracyclines, lincomycins, macrolides, lincosamides, streptogramin B, methicillin, and linezolid.
Antimicrobial Resistance, Biofilm Formation, and Virulence Genes in Enterococcus Species from Small Backyard Chicken Flocks.
The study identified several antimicrobial resistance (AMR) genes in Enterococcus species isolated from backyard chickens, including ermB, ermA, tetM, tetL, vanA, cat, and pbp5. These genes were associated with resistance to erythromycin, tetracycline, vancomycin, chloramphenicol, and ampicillin.
Beyond CC398: Characterisation of Other Tetracycline and Methicillin-Resistant Staphylococcus aureus Genetic Lineages Circulating in Spanish Hospitals.
The study characterizes various tetracycline and methicillin-resistant Staphylococcus aureus genetic lineages circulating in Spanish hospitals, identifying multiple AMR genes including blaZ, tetK, tetL, tetM, ermC, ermB, ant(4')-Ia, aac(6')-Ie-aph(2'')-Ia, mupA, and fusB.
Prevalence and Diversity of Antibiotic Resistant Escherichia coli From Anthropogenic-Impacted Larut River.
The study identified several tetracycline and sulfonamide resistance genes, including tet(A), tet(L), tet(X), sul2, and sul3, in Escherichia coli isolates from the Larut River, highlighting the prevalence of antibiotic resistance in anthropogenically impacted aquatic environments.
Metagenomic Insights Into the Changes of Antibiotic Resistance and Pathogenicity Factor Pools Upon Thermophilic Composting of Human Excreta.
The study identified a decrease in the abundance of various antibiotic resistance genes (ARGs) during thermophilic composting of human excreta, including genes conferring resistance to aminoglycosides, macrolides, sulfonamides, and tetracyclines.
Antimicrobial resistance and virulence factors in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis in low-resource settings
The study identifies various antimicrobial resistance genes in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis, including mecA, tet(K), tet(M), tet(L), aadD, aph(3)-III, ermA, ermC, msrA, mphC, and IS256. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in low-resource settings.
Genomic Characterization of Enterococcus hirae From Beef Cattle Feedlots and Associated Environmental Continuum.
The study identified several AMR genes in Enterococcus hirae isolates from beef cattle feedlots, including tetracycline resistance genes (tet(L), tet(M), tet(O), tet(S/M), tet(O/32/O)), macrolide resistance gene erm(B), and aminoglycoside resistance genes (aac(6')-Iid, ant(6)-Ia, aph(3')-III, sat4).
Genomic Characterization of Enterococcus hirae From Beef Cattle Feedlots and Associated Environmental Continuum.
The study identified several AMR genes in Enterococcus hirae isolates from beef cattle feedlots, including tetracycline resistance genes (tet(L), tet(M), tet(O), tet(S/M), tet(O/32/O)), macrolide resistance gene erm(B), and aminoglycoside resistance genes (aac(6')-Iid, ant(6)-Ia, aph(3')-III, sat4).
Genomic diversity of genus Limosilactobacillus.
The study identified 18 AMR genes in Limosilactobacillus species, primarily in L. reuteri from animal sources, including tetracycline, aminoglycoside, macrolide-lincosamide-streptogramin, and lincomycin resistance genes.
Antimicrobial resistance and genomic analysis of staphylococi isolated from livestock and farm attendants in Northern Ghana.
The study identified several AMR genes in staphylococci from livestock and farm attendants in Northern Ghana, including mecA1, mecA, tet(K), tet(L), tet(M), cat(pC221), sal(A), aadD, dfrK, dfrG, erm(B), fosB, aac(6')-aph(2''), and blaZ, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, aminoglycosides, and macrolides.
Virulence Profiling, Multidrug Resistance and Molecular Mechanisms of Campylobacter Strains from Chicken Carcasses in Tunisia.
The study identified multiple AMR genes and mutations in Campylobacter strains from chicken carcasses in Tunisia, highlighting the presence of multidrug-resistant strains with high resistance rates to various antibiotics.
Antimicrobial Susceptibility Profiles and Molecular Characterisation of Staphylococcus aureus from Pigs and Workers at Farms and Abattoirs in Zambia.
The study identified tetracycline resistance genes (tetM, tetK, tetL) and erythromycin resistance genes (ermB, ermC) in Staphylococcus aureus isolates from pigs and workers in Zambia. These genes were detected through PCR and are associated with resistance to tetracycline and erythromycin, highlighting the need for continued surveillance of antimicrobial resistance in this region.
Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of drug resistance in Staphylococcus aureus, focusing on beta-lactam, glycopeptide, oxazolidinone, MLS-B, aminoglycoside, and other resistance mechanisms. Key genes identified include blaZ, mecA, mecC, vanA, cfr, ermA, ermC, aac(6')-Ib, aph(3')-IIIa, and aadD. Mutations in pbp2 and pbp2a were also found to contribute to resistance.
The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs.
The study identified ermG as a gene that increased in abundance in the feces of treated pigs compared to those that did not receive post-PRRS antimicrobials, indicating its role in macrolide, lincosamide, and streptogramin B resistance.
Diversity and emergence of multi-resistant Staphylococcus spp. isolated from subclinical mastitis in cows in of the state of Piauí, Brazil.
The study identified the presence of blaZ, tetL, tetM, mecA, and vanB genes in Staphylococcus spp. isolates from subclinical mastitis in cows in Piauí, Brazil, indicating multidrug resistance.
Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents.
The study identifies various AMR genes in Enterococcus faecium, including vanA, vanB, ermB, ermT, ermA, aad(6), aph(3')-IIIa, aac(6')-Ie-aph(2')-Ia, sat-4, tetM, tet(W/N/W), dfrG, dfrF, lnuB, optrA, and lsaE, which are associated with different habitats and geographic locations.
Molecular Typing Reveals Environmental Dispersion of Antibiotic-Resistant Enterococci under Anthropogenic Pressure.
The study identified multiple antibiotic resistance genes in Enterococcus isolates from various aquatic environments, highlighting the role of anthropogenic pressure in the spread of antibiotic-resistant enterococci.
Antimicrobial Resistance, Virulence Profiles, and Public Health Significance of Enterococcus faecalis Isolated from Clinical Mastitis of Cattle in Bangladesh.
The study identified tetracycline resistance genes tetK, tetL, and tetM, as well as aminoglycoside resistance genes aacC2, aacC4, and aph(3'')-IIIa, and the vancomycin resistance gene vanB in Enterococcus faecalis isolates from bovine clinical mastitis in Bangladesh.
Antibiotic resistance and pathogenicity assessment of various Gardnerella sp. strains in local China.
The study identified antibiotic resistance genes ermX, lsaC, tetL, and tetM in Gardnerella strains, with seven strains showing strong resistance to metronidazole.
Longitudinal Analysis of Antimicrobial Resistance among Enterococcus Species Isolated from Australian Beef Cattle Faeces at Feedlot Entry and Exit.
Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 Streptococcus suis isolates from healthy pigs.
The study identified 18 AMR genes in non-serotype 2 Streptococcus suis isolates from healthy pigs, including genes conferring resistance to aminoglycosides, macrolides, lincosamides, tetracyclines, oxazolidinones, nucleosides, and phenicols.
First Genome-Based Characterisation and Staphylococcal Enterotoxin Production Ability of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Strains Isolated from Ready-to-Eat Foods in Algiers (Algeria).
The study identified several AMR genes and mutations in S. aureus strains isolated from ready-to-eat foods in Algeria, including blaZ, ermB, lmrS, tet(L), tet(38), aph(3')-IIIa, ant(6)-I, mecA, and a gyrA mutation (S84L) conferring resistance to various antibiotics.
Web-based prediction of antimicrobial resistance in enterococcal clinical isolates by whole-genome sequencing.
The study evaluated the accuracy of whole-genome sequencing (WGS) for predicting antimicrobial resistance in enterococcal clinical isolates. It identified several AMR genes and mutations, including aac(6')-aph(2"), erm(B), erm(T), tet(L), tet(M), vanA, vanB, vanD, optrA, poxtA, and mutations in gyrA and parC, which were validated through genomic sequencing and phenotypic AST.
Antibiotics Limit Adaptation of Drug-Resistant Staphylococcus aureus to Hypoxia.
The study identifies tetL as a tetracycline resistance gene and shows that mutations in rluD and gyrB contribute to increased resistance and fitness under hypoxia.
Distribution Patterns of Antibiotic Resistance Genes and Their Bacterial Hosts in a Manure Lagoon of a Large-Scale Swine Finishing Facility.
The study identified multiple antibiotic resistance genes (ARGs) in manure samples from a swine finishing facility, highlighting the prevalence of resistance to tetracyclines, macrolides, aminoglycosides, and other antibiotics. Key genes included tet(M), lnuA, erm(35), aadS, mphB, dfrG, vga-type ABC-F, lsa-type ABC-F, msr-type ABC-F, optrA, and others, primarily found in Firmicutes, Proteobacteria, and Bacteroidota. These genes were associated with resistance mechanisms such as target alteration, antibiotic inactivation, and efflux pumps.
Genetic characteristics, antimicrobial resistance, and prevalence of Arcobacter spp. isolated from various sources in Shenzhen, China.
The study identified several AMR genes in Arcobacter spp., including beta-lactamase genes (blaOXA464, blaOXA491), tetracycline resistance genes (tet(L), tet(H), tet(M)), a macrolide resistance gene (ere(A)), and aminoglycoside resistance genes (APH(3')-IIIa, ant(6)-Ia, SAT-4). Additionally, a mutation in the gyrA gene (C254T) was found to confer fluoroquinolone resistance.
Methicillin-Resistant Staphylococcus aureus from Diabetic Foot Infections in a Tunisian Hospital with the First Detection of MSSA CC398-t571.
The study identified several AMR genes in S. aureus isolates from diabetic foot infections, including blaZ, erm(B), erm(A), msrA, tet(M), tet(K), tet(L), aac(6')-aph(2"), ant(4')-Ia, and fexA. These genes conferred resistance to various antibiotics such as penicillin, erythromycin, tetracycline, gentamicin, tobramycin, and chloramphenicol.
Dissemination and characteristics of high-level erythromycin-resistant Enterococcus faecalis from bulk tank milk of dairy companies in Korea.
The study identified several AMR genes, including ermB, tetM, tetL, optrA, aac(6')-Ie-aph(2'')-la, ant(6')-Ia, and Int-Tn, in high-level erythromycin-resistant Enterococcus faecalis isolates from bulk tank milk in Korea.
Microbiological Biodiversity of Regional Cow, Goat and Ewe Milk Cheeses Produced in Poland and Antibiotic Resistance of Lactic Acid Bacteria Isolated from Them.
The study identified tetracycline, erythromycin, and chloramphenicol resistance genes in lactic acid bacteria isolated from regional cheeses in Poland.
Farming Practice Influences Antimicrobial Resistance Burden of Non-Aureus Staphylococci in Pig Husbandries.
The study found that organic and alternative pig farming practices are associated with reduced antimicrobial resistance (AMR) in non-aureus staphylococci (NAS) compared to conventional farming. Specific AMR genes such as mecA, blaZ, blaPC1, and others were more prevalent in conventional farms, while organic farms showed lower levels of AMR genes for aminoglycosides, phenicols, and tetracyclines.
Molecular epidemiology, drug resistance, and virulence gene analysis of Streptococcus agalactiae isolates from dairy goats in backyard farms in China.
The study identified multiple AMR genes in S. agalactiae isolates from dairy goats in China, including pbp2b, tetL, tetM, tetK, tetO, ermA, ermB, mefA, aphA3, aad6, lnu(B), gryA, and parC, which confer resistance to various antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, lincosamides, and quinolones.
Virulence and antibiotic-resistance genes in Enterococcus faecalis associated with streptococcosis disease in fish.
The study identified various antibiotic-resistance genes in three strains of Enterococcus faecalis associated with streptococcosis in fish, including genes conferring resistance to tetracycline, macrolide-lincosamide-streptogramin, and vancomycin.
Molecular characterization of Arcobacter butzleri isolates from poultry in rural Ghana.
The study identified several antimicrobial resistance genes in Arcobacter butzleri isolates from poultry in Ghana, including blaOXA-464, tetM, ermB, and others, highlighting the presence of multidrug-resistant strains and the potential for horizontal and vertical transmission of resistance genes.
Comparative Genome Analysis of Enterococcus cecorum Reveals Intercontinental Spread of a Lineage of Clinical Poultry Isolates.
The study identifies six genes associated with avian clinical isolates of Enterococcus cecorum, which can help distinguish them from nonclinical isolates.
An in-house 45-plex array for the detection of antimicrobial resistance genes in Gram-positive bacteria.
The study describes an in-house 45-plex array for detecting antimicrobial resistance genes in Gram-positive bacteria, identifying optrA, poxtA, and vanA as significant resistance markers in Enterococcus and Staphylococcus isolates.
Prevalence, multiple antibiotic resistance and virulence profile of methicillin-resistant Staphylococcus aureus (MRSA) in retail poultry meat from Edo, Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus (MRSA) isolated from retail poultry meat in Edo, Nigeria, highlighting the prevalence of multidrug-resistant MRSA and the presence of virulence factors that pose a public health concern.
Enterococcal Linear Plasmids Adapt to Enterococcus faecium and Spread within Multidrug-Resistant Clades.
The study identifies pELF1-like plasmids in Enterococcus faecium that carry multiple antimicrobial resistance genes, including vancomycin resistance determinants, aminoglycoside resistance genes, macrolide resistance genes, tetracycline resistance genes, and oxazolidinone resistance genes. These plasmids are associated with multidrug-resistant clades and demonstrate high stability and self-transmissibility.
The Plasmidomic Landscape of Clinical Methicillin-Resistant Staphylococcus aureus Isolates from Malaysia.
The study identified various plasmid-borne antimicrobial resistance genes in Malaysian MRSA isolates, including ermC, cat, tetK, tetL, aadD, aac(6')-Ie-aph(2")-Ia, lnuA, cadAC, cadDX, copB, mco, arsB, arsC, and qacA, contributing to multidrug resistance.
Antibiotic Resistance Profiles and ARG Detection from Isolated Bacteria in a Culture-Dependent Study at the Codfish Industry Level.
The study identified various antibiotic resistance genes in bacteria isolated from codfish products and environmental samples, highlighting the presence of tetracycline, clindamycin, and oxacillin resistance genes in Staphylococcus spp., as well as beta-lactam and carbapenem resistance genes in Gram-negative bacteria.
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
The study identified numerous antimicrobial resistance (AMR) genes in methicillin-resistant Staphylococcus aureus (MRSA) CC398 isolates from diseased swine in Germany, including beta-lactam, tetracycline, macrolide, lincosamide, streptogramin B, phenicol, aminoglycoside, and fluoroquinolone resistance genes. These genes were often located on small transposons or plasmids, contributing to the multidrug resistance profile of the isolates.
Exploring the third-generation tetracycline resistance of multidrug-resistant livestock-associated methicillin-resistant Staphylococcus aureus ST9 across healthcare settings in China.
The study identifies the tetracycline resistance genes tet(L) and tet(63) and the rpsJ Y58D mutation as responsible for third-generation tetracycline resistance in multidrug-resistant ST9 MRSA isolates.
Analysis of Antibiotic-Resistant and Virulence Genes of Enterococcus Detected in Calf Colostrum-One Health Perspective.
The study identified multiple antibiotic-resistant genes in Enterococcus isolates from bovine colostrum, including tet(K), tet(L), tet(M), erm(B), and ant(6)-Ia, which confer resistance to tetracycline, erythromycin, and streptomycin. High rates of multidrug resistance were observed.
ARGs Detection in Listeria Monocytogenes Strains Isolated from the Atlantic Salmon (Salmo salar) Food Industry: A Retrospective Study.
The study identified various AMR genes in L. monocytogenes strains from Atlantic salmon, including tetracycline resistance genes (tetC, tetD, tetK, tetL, tetS), aminoglycoside resistance genes (aadA, strA, aacC2, aphA1, aphA2), macrolide resistance genes (cmlA1, catI, catII), and oxazolidinone resistance genes (cfr, optrA, poxtA).
Evaluation of Enterotoxins and Antimicrobial Resistance in Microorganisms Isolated from Raw Sheep Milk and Cheese: Ensuring the Microbiological Safety of These Products in Southern Brazil.
The study identified several antimicrobial resistance genes, including tetM, ermB, strA, tetL, sul1, sul2, and AAC(6)', in Staphylococcus spp. isolated from raw sheep milk and cheese in southern Brazil. These genes conferred resistance to various antibiotics, highlighting the prevalence of antimicrobial resistance in these microorganisms.
Genetic characterization of MDR genomic elements carrying two aac(6')-aph(2") genes in feline-derived clinical Enterococcus faecalis isolate.
The study identified a multidrug-resistant E. faecalis isolate (ESC1) carrying a novel composite transposon with two aac(6')-aph(2") genes, along with several other resistance genes on plasmids, contributing to resistance against multiple antibiotics.
Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin.
The study identified the presence of the tetracycline resistance gene tetK in Mammaliicoccus sciuri isolates, which was associated with tetracycline resistance. The gene was found on small plasmids, suggesting a potential mechanism for horizontal gene transfer.
Oxytetracycline-resistant Paenibacillus larvae identified in commercial beekeeping operations in Saskatchewan using pooled honey sampling.
The study identified the tetracycline-resistance gene tet(L) on the P. larvae-specific plasmid pMA67 in 9 out of 11 oxytetracycline-resistant P. larvae isolates sequenced.
Genetic characteristics, antimicrobial susceptibility, and virulence genes distribution of Campylobacter isolated from local dual-purpose chickens in central China.
The study identified the gyrA T86I mutation and tet(O) as the most prevalent resistance mechanisms in Campylobacter isolates from local dual-purpose chickens in central China, with high resistance rates to ciprofloxacin and tetracycline.
Genomic Characterization of a Tetracycline-Resistant Strain of Brochothrix thermosphacta Highlights Plasmids Partially Shared between Various Strains.
The study identifies three plasmids in the tetracycline-resistant strain B. thermosphacta BT469, including pBT469-2 carrying the tet(L) gene responsible for tetracycline resistance and pBT469-1 containing the tetR and qacH genes.
Probiotics Modulate Host Immune Response and Interact with the Gut Microbiota: Shaping Their Composition and Mediating Antibiotic Resistance.
The study identifies tetracycline resistance genes (tetM, tetL) and a fluoroquinolone resistance gene (parC) in probiotic strains, highlighting the potential for probiotics to mediate antibiotic resistance.
Probiotics Modulate Host Immune Response and Interact with the Gut Microbiota: Shaping Their Composition and Mediating Antibiotic Resistance.
The study identifies tetracycline resistance genes (tetM, tetL) and a fluoroquinolone resistance gene (parC) in probiotic strains, highlighting the potential for probiotics to mediate antibiotic resistance.
Characterization of a Tigecycline-, Linezolid- and Vancomycin-Resistant Clinical Enteroccoccus faecium Isolate, Carrying vanA and vanB Genes.
The study identifies the presence of vanA and vanB genes, along with poxtA, fexB, tet(M), and tet(L) in a multidrug-resistant Enterococcus faecium isolate, highlighting the coexistence of multiple resistance mechanisms.
A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA).
The review highlights the role of PBP2a, encoded by the mecA gene, in conferring resistance to β-lactam antibiotics in MRSA. It also discusses the importance of β-lactamase enzymes, such as those encoded by blaZ, in degrading β-lactam antibiotics.
Antimicrobial resistance and whole genome sequencing of novel sequence types of Enterococcus faecalis, Enterococcus faecium, and Enterococcus durans isolated from livestock.
The study identifies several antimicrobial resistance genes in Enterococcus species isolated from livestock in South Africa, highlighting the presence of multidrug-resistant strains and emphasizing the need for genomic surveillance to monitor the spread of antimicrobial resistance in food chain animals.
Occurrence and Antimicrobial Resistance among Staphylococci Isolated from the Skin Microbiota of Healthy Goats and Sheep.
The study identified several antimicrobial resistance genes in staphylococci isolated from the skin microbiota of healthy goats and sheep, including mecA, blaZ, tetL, tetK, ermB, ermC, lnu, and grlA. These genes confer resistance to various antibiotics such as methicillin, penicillin, tetracycline, macrolides, lincosamides, and fluoroquinolones.
Genomic insights into plasmid-mediated antimicrobial resistance in the bacterium Bhargavaea beijingensis strain PS04.
The study identified a novel plasmid-mediated antimicrobial resistance in Bhargavaea beijingensis strain PS04, carrying the ermT and tet(L) genes, which confer resistance to macrolides, lincosamides, streptogramin B, and tetracycline.
Enterococcus species: insights into antimicrobial resistance and whole-genome features of isolates recovered from livestock and raw meat in Ghana.
The study identified various antimicrobial resistance genes in Enterococcus spp. isolated from livestock and raw meat in Ghana, including genes conferring resistance to erythromycin, tetracycline, chloramphenicol, and other antibiotics. Notable genes include aac(6')-Ii, aph(3')-III, ant(6)-Ia, erm(B), erm(T), msr(C), lsa(A), lsa(E), lnu(B), tet(L), tet(M), tet(S), dfrG, cat, pbp5, and ClpL.
Identification of knowledge gaps in whole-genome sequence analysis of multi-resistant thermotolerant Campylobacter spp.
The study identified 22 different resistance genes and gene variants, including erm(B), aph(3')-IIIa, aadE, catA, lnu(C), blaOXA, sat4, tet(O), and point mutations in gyrA, 23S rRNA, and rpsL, associated with antimicrobial resistance in thermotolerant Campylobacter spp.
Multidrug-resistant Enterococcus faecium strains enter the Norwegian marine environment through treated sewage.
The study identified multidrug-resistant Enterococcus faecium strains carrying resistance genes such as aac(6')-Ii, erm(B), erm(T), tet(L), tet(M), and msr(C), as well as mutations in gyrA and parC contributing to ciprofloxacin resistance.
Antimicrobial resistance and virulence profiling of Staphylococcus pseudintermedius isolated from cats, Bangladesh.
The study identified methicillin-resistant S. pseudintermedius (MRSP) with the mecA gene, erythromycin resistance genes ermA and ermB, and tetracycline resistance genes tetK and tetL in cats in Bangladesh.
Complete genome sequence of the linezolid-resistant clinical Enterococcus faecalis N23-3408 linked to a livestock lineage in Switzerland.
The linezolid-resistant E. faecalis N23-3408 harbors the optrA gene on a plasmid, along with other resistance genes including cat, erm(B), fexA, tet(L), and tet(M).
The Genetic Landscape of Antimicrobial Resistance Genes in Enterococcus cecorum Broiler Isolates.
The study identified several antimicrobial resistance genes (ARGs) in Enterococcus cecorum isolates, including ant(6)-la, ermB, lsaE, tet(M), tet(L), and vanA, which are associated with resistance to aminoglycosides, macrolides, lincosamides, tetracyclines, and glycopeptides. Additionally, point mutations in GyrA, GyrB, ParC, and PBP2x were found to contribute to resistance against enrofloxacin and β-lactam antibiotics.
Antimicrobial resistance, enterotoxin and biofilm production genes in Staphylococcus spp. isolated from facilities and fomites in veterinary hospital in the Caatinga biome.
The study identified several antimicrobial resistance genes including blaZ, mecA, tetM, tetL, and tetK in Staphylococcus spp. isolates from a veterinary hospital in the Caatinga biome. Additionally, the icaD gene associated with biofilm production was detected in one S. sciuri strain.
Evaluation of Antimicrobial Resistancein Clinical Isolates of Enterococcus spp. Obtained from Hospital Patients in Latvia.
The study identifies several AMR genes and mutations in Enterococcus isolates, including vanB for vancomycin resistance, lsaA, lsaE, lnuB for lincosamide resistance, tetM and tetL for tetracycline resistance, aac6'-Ii, aac6'-aph2'', aph3'-III, and ant6-Ia for aminoglycoside resistance, msrC, ermB, and ermT for macrolide resistance, and mutations in gyrA, parC, pbp5, and 23S rRNA for fluoroquinolone, penicillin, and linezolid resistance.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
A first study of meat-borne enterococci from butcher shops: prevalence, virulence characteristics, antibiotic resistance and clonal relationship.
The study identified tetracycline resistance gene tet(L), aminoglycoside resistance gene aac(6')-Ie-aph(2")-la, and macrolide/lincosamide/streptogramin B resistance gene ermB in Enterococcus isolates from meat samples.
Antimicrobial Resistance in Coagulase-Negative Staphylococci: Resistome, Mobiloome, and Relatedness
The study identifies multiple AMR genes and mutations in CoNS isolates from various hosts, highlighting the spread of multidrug resistance and the role of mobile genetic elements in the dissemination of resistance traits.
Antibiotic resistance, virulence genes, and phylogenetic groups of bacteria isolated from wild passerine birds in Iran.
The study identified tetracycline resistance genes (tet(A), tet(B), tet(M), tet(L)) and the blaTEM gene associated with ampicillin resistance in bacteria isolated from wild passerine birds in Iran.
The gut microbiota of wild birds undergoing rehabilitation as a reservoir of multidrug-resistant enterococci in a metropolitan area in Brazil.
The study identified multiple antimicrobial resistance genes in enterococci isolated from wild birds, including genes conferring resistance to aminoglycosides, erythromycin, tetracycline, and streptogramins.
Safety assessment of enterocin-producing Enterococcus strains isolated from sheep and goat colostrum.
The study identified antibiotic resistance genes aph(3')-IIIa, tetM, and tetL in certain Enterococcus strains, indicating resistance to gentamicin and tetracycline. However, most strains showed susceptibility to clinically significant antibiotics.
The healthy human gut can take it all: vancomycin-variable, linezolid-resistant strains and specific bacteriocin-species interplay in Enterococcus spp.
The study identifies linezolid resistance genes optrA and poxtA in Enterococcus faecium and Enterococcus thailandicus isolates, along with a vancomycin-variable E. faecium strain. It also reveals the increasing prevalence of E. lactis in the healthy human gut and the complex interplay of bacteriocin gene profiles among Enterococcus species.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Cockroaches as Reservoirs, Vectors, and Potential Sentinels of Multidrug-Resistant Bacteria in Ugandan Communities: A Retrospective Analysis.
The study identified tetracycline and sulfonamide resistance genes (tetA, sul1, sul2) in Escherichia coli and tetracycline resistance genes (tetM, tetL) in Enterococcus spp. from cockroaches in Ugandan communities.
Comparison of Staphylococcus pettenkoferi Isolated from Human Clinical Cases and Cat Carriers Regarding Antibiotic Susceptibility and Biofilm Production.
The study identified several AMR genes in Staphylococcus pettenkoferi isolates from human and feline sources, including blaZ, mecA, ermA, tet(L), vanA, aph3-IIIa, ter(M), mupA, and fusB, which confer resistance to various antibiotics such as penicillins, methicillin, erythromycin, tetracyclines, vancomycin, gentamicin, mupirocin, and fusidic acid.
High-Risk VREfm Clones and Resistance Determinants in a Thai Hospital.
The study identified the vanA gene as the primary determinant of vancomycin resistance in all 29 VREfm isolates. Additional resistance genes such as aac(6')-Ii, ant(6')-Ia, erm(B), msr(C), tet(L), tet(M), aph(3')-III, aph(2'')-Ia, and inu(B) were also characterized, contributing to resistance against a variety of antibiotics.
Isolation, Antimicrobial Susceptibility, and Genotypes of Three Pasteurellaeae Species Prevalent on Pig Farms in China Between 2021 and 2023.
The study identified 18 antimicrobial resistance genes in three Pasteurellaeae species, including tetracycline, beta-lactam, sulfonamide, aminoglycoside, and macrolide resistance genes. High frequencies of tet(L), tet(M), tet(A), blaTEM, sul2, aph(3')-Ia, dfrA12, qnrS1, strA, sul3, and mef(B) were observed.
Wild Birds as Drivers of Salmonella Braenderup and Multidrug Resistant Bacteria in Wetlands of Northern Italy.
The study identifies several AMR genes in bacterial isolates from wild aquatic birds in Northern Italy, including beta-lactamases (blaTEM, blaCMY-1, blaCMY-2, blaNDM, blaKPC), colistin resistance genes (mcr-2, mcr-3, mcr-4), tetracycline resistance genes (tetA, tetB, tetC, tetL, tetM, tetK), macrolide resistance genes (ermB, vatD, vgA, msrC), vancomycin resistance genes (vanC1, vanC2, vanM, vanG), sulfonamide resistance genes (sul1, sul2, sul3), aminoglycoside resistance genes (aac(3), aac(6')-Ib, aph(3')-Ia, armA, rmtB, rmtC, rmtF), and nitrofurantoin resistance genes (nfsA, nfsB).
Antimicrobial resistance and molecular characteristics of bovine mastitis-associated methicillin-resistant Staphylococcus aureus: potential for cross-species transmission of ST59-MRSA.
The study identified several antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates from bovine mastitis, including erm(B), erm(C), tet(L), tet(K), mecA, fexA, aac(6')-aph(2''), ant(4')-Ia, ant(6)-Ia, and aph(2'')-Ia. These genes were associated with resistance to various antibiotics such as erythromycin, tetracycline, penicillin, oxacillin, cefoxitin, florfenicol, and gentamicin.
Rabbit carcasses as important vectors of multidrug-resistant Enterococcus faecalis, but not E. faecium: prevalence and molecular characterization from a study in Poland.
The study identified multiple AMR genes in Enterococcus faecalis isolates from rabbit carcasses, including aac(6')-Ie-aph(2")-Ia, ant(6)-Ia, aph(3')-IIIa, ermB, tetM, and tetL, which were consistent with the observed phenotypic resistance patterns.
Overlooked Enterobacterales as hosts of antimicrobial resistance in aquatic environments.
The study identified several AMR genes in environmental Enterobacterales isolates, including blaTEM-1, blaCTX-M, tetA, tetB, tetC, tetL, tetM, sul1, sul2, qnrS, ermB, and mefA, which conferred resistance to various antibiotics such as ampicillin, ceftazidime, cefepime, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and erythromycin.
Prevalence and antimicrobial resistance of methicillin-resistant and methicillin-susceptible Staphylococcus in small- to medium-scale and large-scale dairy farms in Thailand.
The study identified several AMR genes and mutations in Staphylococcus isolates from small- to medium-scale and large-scale dairy farms in Thailand, highlighting differences in resistance profiles between farm types.
Global analysis of the genomic diversity, antimicrobial resistance and potential vaccine candidates carried by the major global bovine pathogen Streptococcus uberis.
The study identified 35% of S. uberis isolates carrying acquired antimicrobial resistance genes, including ant(6)-la, aph(3')-lla, tetL, tetM, tetS, lnuC, and lnuD. Additionally, mutations in penicillin-binding proteins pbp2b (N366I, T402I) and pbp2x (E381K, Q554E, V590A, G600E) were associated with reduced penicillin susceptibility.
Antimicrobial susceptibility and genomic characterization of Lactococcus formosensis, Lactococcus garvieae, and Lactococcus petauri in Hong Kong.
The study identified several AMR genes and mutations in Lactococcus species, including mdtA, lsaD, tetS, and tetL, which confer resistance to clindamycin and minocycline. Mutations in lsaD were associated with clindamycin susceptibility.
Comparative analysis of colonization and survival strategies of regionally predominant LA-MRSA clones ST398 and ST9.
The study found that epidemic Chinese ST9 isolates carried multiple resistance genes, including fexA, tet(L), and aadE-spw-lsa(E)-lnu(B), exhibiting broad resistance to clinically important antibiotics such as tylosin, florfenicol, and tetracyclines.
Phenotypic and genomic analysis of the emerging poultry pathogen Enterococcus cecorum in UK isolates.
The study identifies multiple AMR genes and mutations in UK E. cecorum isolates, including tet(L), tet(M), ant(6)-la, ermB, NarA/NarB, and lnuC, as well as mutations in pbp2x and gyrA that confer resistance to various antibiotics.
Antimicrobial resistance reservoirs in salmon and broiler processing environments, sidestreams, and waste discharges.
The study identified several high-risk AMR genes in salmon and broiler processing environments, including multidrug resistance genes TolC and mdtE, tetracycline genes tet(L) and tet(M), aminoglycoside genes APH(3′)-IIIa and APH(6)-Id, and beta-lactam genes mecA and mecR1. Additionally, the study found quinolone-resistant Escherichia coli (QREC) in waste discharges from two broiler processing plants and multidrug resistant (MDR) E. coli in one plant.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Emergence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus ST398 in Wild Birds, Brazil.
The study reports the first detection of livestock-associated Methicillin-Resistant Staphylococcus aureus ST398 in wild birds in Brazil, highlighting the emergence of antimicrobial-resistant S. aureus in a protected Atlantic Forest fragment. The MRSA isolates exhibited a broad resistome, including genes for resistance to multiple antimicrobial classes.
Temporal dynamics of the resistome in gilts raised in an organic operation in which semen used for artificial insemination is the primary source of antimicrobial exposure.
The study identified several tetracycline, aminoglycoside, and MLS resistance genes in the fecal microbiome of gilts, with no significant increases in ARG abundance following exposure to semen extenders containing antibiotics.
Genomic Insights into Multidrug-resistant Mammaliicoccus sciuri Carrying Novel Staphylococcal Cassette Chromosome mec (SCCmec) Elements and Plasmids from Farm Ruminants on the East Coast of Peninsular Malaysia.
The study identified multiple antimicrobial resistance genes in four multidrug-resistant Mammaliicoccus sciuri isolates from farm ruminants in Peninsular Malaysia, including mecA, ermY, mphC, msrA, tetL, tetS, aadD, ant(6)-Ia, aac(6')-Ie-aph(2")-Ia, fexA, icaA, icaB, icaC, icaD, icaR, sspA, ndk, and lgt. These genes confer resistance to various antibiotics, including β-lactams, macrolides, tetracyclines, aminoglycosides, and chloramphenicol.
Elucidation of population-based bacterial adaptation to antimicrobial treatment by single-cell sequencing analysis of the gut microbiome of a hospital patient.
The study identified 29 ARG subtypes across eight types in 13 known, five unknown, and 18 unclassified species, highlighting the complex and dynamic nature of antimicrobial resistance in the gut microbiome. Notably, the cfr(C) gene was detected in 11 bacterial species following antimicrobial treatment, with mutation patterns characterized in several species.
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