Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline resistance ribosomal protection protein Tet(M)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Tet(M) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 421 | TETRACYCLINE, MINOCYCLINE +7 | Clostridium perfringens +220 | Toronto, Europe|Poland|Spain, New Zealand, Italy, Europe, Brazil, Ireland, North Carolina|Ohio, Asia|Australasia, North America|Latin America|India|Taiwan|Australia|Eastern Europe|Western Europe|South Africa, Taiwan, Poland, United States, Nigeria|Portugal, US West Coast, Texas|Kenya, Portugal, France, Vietnam, North Carolina|Kansas, Switzerland, United States|USA, South East Queensland, Australia|Coomera River, Global|India|Spain, Belgium, Tunisia, Portugal|Germany|Italy, Venezuela, Northwest USA, Denmark|USA|Australia|PNG, Denmark|United States|Italy|Germany, Thailand|Israel, Gulf of Gdansk|Vistula River, coastal aquaculture site in Japan|marine environment, Egypt, Warsaw, Spain, Korea, Iran, Japan, Canada, Denmark|Europe, Samoa|Vanuatu, France|Switzerland, China, Nsukka agricultural zone, Nigeria, England|Wales, Japan|France|Denmark|United States|Brazil|Spain|Portugal|Germany, Denmark, Denmark|Spain|Japan, Afghanistan, USA|Flagstaff, USA, Catalonia, Spain, United Kingdom, global|Europe|Belgium, Europe|Spain, Alberta, Niger, USA|France|Portugal|China|Brazil|Germany|Sweden|Italy|Spain|Denmark|Japan|Korea|Europe|Asia|North America, Japan|aquaculture, China|Three Gorges Reservoir (TGR), China, South Brazil, Denmark|Spain|France|Netherlands, Russia, Germany, Accra, Ghana, USA, Texas, Hong Kong, Global, Alberta, Canada, Liverpool, UK, Shanghai, China, Thailand, Czech Republic|Italy|Portugal, Wales|England, South Korea, Sweden|Italy|Denmark, Bangladesh, USA|Peru|Egypt|Cambodia|Kenya, GA, USA, Kuwait, North America|Europe, Pacific region|Hawaii, Nigeria, Lebanon, Norway, South Africa, Netherlands, Argentina, North America, China|United States of America|United Kingdom|Canada|Spain|Netherlands|France|Germany|Denmark|Europe|North America, United States|Germany, Africa|North America|South America|Asia|Europe, Alberta|Canada|Alberta, Canada, Southwest China, Poland|Ukraine, Israel, Greece, Czech Republic, Guangdong, Thailand|Singapore|Hong Kong|Laos|Vietnam|Malaysia|Southeast Asia, Austria, Nigeria|Germany|Singapore|China, Cambodia, Bangladesh|South Africa|Nigeria|Pakistan|Ethiopia|USA|UK, Northern Ghana, Central Italy, Europe|United States|Asia, Africa|Asia|America|Europe|Oceania|global, Shenzhen, China, Portugal|Spain|Italy|Morocco, China|global, Kenya, Ontario, Canada, France|United States|Germany|Belgium|Poland, Tanzania, Japan|Denmark|Norway|China|United States|Switzerland|India|Netherlands, Argentina|Australia|Brazil|China|India|United States, West Africa, Global|Guinea|Austria|Vietnam|China|Spain|Canada|Hong Kong|Malaysia|Germany|South Africa|Vancouver|Vienna, Northern Germany, Algeria, Rio de Janeiro, Central Adriatic|Central Adriatic Sea, Chettia Chlef Hospital, Ghana, La Rioja, Spain, Bangkok, Thailand, China|Europe|Asia|North America|South America, China|UK|Canada|Thailand|Netherlands|USA|Denmark|Spain|other nations, Saudi Arabia, global, Sri Lanka, Spain|Portugal|Germany|UK|Switzerland|Thailand|Italy, Chennai, India, France|Germany|Netherlands|Norway|Spain|United Kingdom|Europe, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, California, United States|Minnesota, Northwest Ethiopia|Ethiopia, Hubei Province, China, Europe|Spain|Netherlands, Norway|Sweden, Tianjin|Southern Karnataka, Mayurbhanj, Odisha, India|India, Southeast Nigeria|Nigeria, Europe|UK, Europe|Thailand, Europe|Norway|Romania, USA|China|Singapore, Democratic Republic of the Congo, Australia, Egypt|Northern Egyptian governorates of Kafr El-Sheikh and Dakahlia, Sardinia, Italy, Sichuan Province, China | 1986, 1988, 1990, 1992, 1994, 1995, 1996, 1997, 1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AF329848.1 | AAK17952.1 |
| tet(M) | Card DatabaseResFinder Database | 2 | MINOCYCLINE, TETRACYCLINE +1 | Erysipelothrix rhusiopathiae +1 | - | 1996 | AB039845.1 | BAB82500.1 |
| tetM | Reslit | 361 | tetracycline, minocycline +3 | Streptococcus pneumoniae +189 | Iceland, Sweden, Europe|North America|Asia, Germany, Argentina, Germany|Austria, United States|Japan|Canada|Spain|New Zealand|Denmark|U.S.|U.K.|Boston, Kansas|United States, United Kingdom, Spain, South-West Nigeria|North-East Nigeria, Gambia, Maine|New Hampshire, Turkey, Malaysia, Europe, Beijing, United States|Switzerland|Czech Republic|New Zealand, United States|Afghanistan, East Africa, Nigeria, Belgium, United States, Netherlands, Europe|Africa|Asia|Australia|Americas|global, Toronto, Ontario, Canada, USA, Manitoba|Saskatchewan, Iran, Pakistan, Eastern Cape, South Africa, Kuwait, Thailand|Fiji|Kenya, Baltic Sea, Europe|Asia, Middle East|Lebanon, Poland, Costa Rica, England|USA|Canada, Africa|Asia|Europe|South America|Oceania, UK, China, Colombia, New Zealand, Brazil, Australia, Southern Alberta, Canada, North China, Finland, Serbia, Czech Republic, Canada|United Kingdom|Global, Western Hemisphere|South America|Central America|North America, Chile, Italy, The Netherlands, Michigan, USA, Australia|Europe|Asia|North America|New Zealand, Delta State, Nigeria, Lithuania, northern Arizona|Northern Arizona, Ecuador, Egypt, Japan, Cameroon, Hainan, China, Europe|Israel|United Kingdom|Republic of Ireland|Italy, South Korea, Vermont|United States, India, Canada|United Kingdom|United States, Denmark, Taiwan, Spain|porcine, Korea, South Africa, Eastern Cape Province, South Africa, Houston, TX, Abbottabad|Pakistan, Europe|Spain, Kenya, Ethiopia, Eastern Cape Province, Republic of South Africa|South Africa, Brazilian Pampa biome|Brazil, Myanmar, Portugal, Europe|Christmas Island, South Korea|Australia|America|The Netherlands|China, Australia|New Zealand, South Africa|Nigeria, Western Uganda, Portugal|Brazil, Philippines, Alberta, Canada, KwaZulu-Natal, South Africa, Northern Xinjiang, China, Vietnam, Northern Algeria|cattle, Asia|Europe|North America|Australia/New Zealand, Rwanda, Ghana, human gut|animal gut|environmental samples, Asia|Europe|North America, Saudi Arabia, Europe|North America|Netherlands|Denmark|Pennsylvania|United States|France, Mexico, Georgia, USA|Georgia, Norway, Europe|USA|Portugal|Germany|Australia|China|India|Pakistan|Sweden|Colorado, Alberta, Zambia, Northeast China, US, Abuja, Nigeria, Canada|United Kingdom|Alberta, Romania|Cluj County, North Western Romania, Bangladesh, South-eastern Poland, Europe|Western Pacific|Africa|Kenya|Morocco|Qatar|South Africa|Uganda, Northern Greece, Southern Italy|Campania Region, Uruguay, Indonesia, swine manure, New York, Southern Germany|various, South Africa|Poland|Czech Republic|Romania|China|United States|Spain|Germany|France|Canada|Japan|Brazil|India|Croatia|Hungary|Slovenia|Slovakia|Czechia|Austria|Puerto Rico|Switzerland|Nigeria|Norway|Finland|Denmark|Sweden|Italy|South Korea|USA|UK|Australia|New Zealand|Mexico|Russia|Turkey|Egypt|Kenya|Ethiopia|Uganda|Tanzania|Malawi|Zambia|Zimbabwe|Mozambique|Madagascar|Comoros|Mayotte|Réunion|Guadeloupe|Martinique|Saint Martin|Saint Barthélemy|French Guiana|Suriname|Guyana|Argentina|Chile|Peru|Bolivia|Paraguay|Uruguay|Colombia|Venezuela|Ecuador|Costa Rica|Panama|Nicaragua|Honduras|El Salvador|Guatemala|Belize|Alaska|Hawaii|Maine|Massachusetts|New York|California|Texas|Florida|Illinois|Pennsylvania|Ohio|Georgia|North Carolina|Michigan|Virginia|Washington|Arizona|Colorado|Connecticut|Delaware|District of Columbia|Idaho|Indiana|Iowa|Kansas|Kentucky|Louisiana|Maryland|Minnesota|Mississippi|Missouri|Montana|Nebraska|Nevada|New Hampshire|New Jersey|New Mexico|North Dakota|Oklahoma|Oregon|Rhode Island|South Carolina|South Dakota|Tennessee|Utah|Vermont|West Virginia|Wisconsin|Wyoming, Argentina|United States, global|China, Swiss Canton Tessin|various herds|Switzerland, Hunan Province|China, Thuringia, Germany, Eastern China, World Health Organization European Region|World Health Organization Western Pacific Region|World Health Organization Americas Region, Guangdong Province, China, Shanghai, China, Peruvian Amazon, Spain|Northern Spain, Southwest China, Thailand|Pig|Pork, Caatinga biome, Edo State, Nigeria, Latvia, Scotland, Slovakia, Uganda, Türkiye, Davao City, Philippines, Singapore, Europe|Africa|North America|South America|Asia|Oceania, USA|Rochester, NY, Bulgaria, China|Hunan Province, mariculture areas, Thailand, China|Xinjiang, Indonesia|USA|China|Europe|Finland, United Arab Emirates, Northern Italy, Hubei, China, Europe|Spain|Netherlands, Inner Mongolia|Inner Mongolia, China, Australia|Czech Republic|Italy|New Zealand, Europe|USA, Northwest China, Western Cape, South Africa|South Africa, North America|Canada, Haikou, China, Central Vietnam, Southern Benin|Benin, Xinjiang, China, Free State Province, South Africa|South Africa, Niger, northwest China|China, Poland|Australia, Iraq, China|Shandong Province, China | 1999, 2000, 2001, 2003, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AF261033|AF261034|AF261035|AF261036|AF261037|AF261038|AF261039|AF240471|AF240472|AF210432 | - |
| tet (M) | Reslit | 15 | tetracycline, doxycycline | Neisseria gonorrhoeae +8 | Russia, Japan, Europe|Asia|Belgium|Netherlands|Thailand, North America|Washington, St. Louis, MO, USA, United Kingdom, China, Vietnam, Finland|Eastern Finland, Italy, Ontario, Canada, California, Egypt|Northern Egyptian governorates of Kafr El-Sheikh and Dakahlia | 2008, 2011, 2012, 2017, 2018, 2019, 2020, 2021, 2022, 2024, 2025 | AB571865 | - |
| TetM | Reslit | 7 | tetracycline, minocycline +1 | Staphylococcus aureus +6 | United Kingdom, New York|Portugal|Spain|USA, Shaanxi Province, South Africa | 2010, 2011, 2012, 2014, 2021, 2023, 2024 | FN433596|FN433597|FN433598 | - |
| tet M | Reslit | 15 | tetracycline, doxycycline | Enterococcus faecalis +22 | Spain, Yangzhou City, Algeria, South Africa, Europe|South America, Guangdong Province, Europe, Turkey, Eastern Cape province, South Africa|South Africa, Edo State, Nigeria, Shandong, China, south Tunisia, Egypt | 2011, 2017, 2018, 2021, 2022, 2023, 2025 | KX981212|KX981438|KY048431|KY048441 | - |
| tetm | Reslit | 1 | tetracycline | Vibrio harveyi 345 | Southern China | 2019 | CP025537|CP025538|CP025539|CP025540 | - |
| tetM-02 | Reslit | 1 | tetracycline | - | Australia | 2020 | SRP201741 | - |
| TETM-02 | Reslit | 1 | tetracycline | - | - | 2021 | PRJNA705824 | - |
| tet(M ) | Reslit | 1 | tetracycline | Enterococcus faecium +2 | Portugal | 2025 | KT862784|MH746818|CP161870|CP161865|CP161871|CP161866 | - |
In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936).
The study characterizes the in vitro and in vivo antibacterial activities of TBG-MINO, a novel glycylcycline, against various tetracycline-resistant strains, including those with tet(A), tet(B), tet(C), tet(D), tet(K), and tet(M) resistance determinants.
Molecular characterization of multidrug resistance in Streptococcus mitis.
The study identified the presence of mef, ermB, and tet(M) genes in multidrug-resistant Streptococcus mitis isolates, contributing to resistance against macrolides, clindamycin, and tetracycline, respectively.
Characterization of the Tn916-like transposon Tn3872 in a strain of abiotrophia defectiva (Streptococcus defectivus) causing sequential episodes of endocarditis in a child.
The study identifies the presence of the ermB and tet(M) genes in a strain of Abiotrophia defectiva, which confer resistance to erythromycin, clindamycin, tetracycline, and minocycline. These resistance genes are located on a chromosomally borne Tn916-like transposon, Tn3872.
Molecular evolution in a multidrug-resistant lineage of Streptococcus pneumoniae: emergence of strains belonging to the serotype 6B Icelandic clone that lost antibiotic resistance traits.
The study identifies the loss of tetracycline and erythromycin resistance in certain strains of the serotype 6B Icelandic clone of Streptococcus pneumoniae, indicating the potential for resistance gene inactivation or deletion.
Genetic diversity of the tet(M) gene in tetracycline-resistant clonal lineages of Streptococcus pneumoniae.
The study identifies six alleles of the tet(M) gene in tetracycline-resistant Streptococcus pneumoniae isolates, highlighting genetic diversity within clonal lineages.
Molecular ecology of tetracycline resistance: development and validation of primers for detection of tetracycline resistance genes encoding ribosomal protection proteins.
The study identified and characterized multiple tetracycline resistance genes encoding ribosomal protection proteins (RPPs) including tet(M), tet(O), tet(W), tet(Q), tet(S), tet(T), tetB(P), and otrA. These genes were detected in various bacterial species and environments, highlighting their prevalence and potential for horizontal gene transfer.
Unusual occurrence of M type 77, antibiotic-resistant group A streptococci in southern Sweden.
The study identifies tetM, ermB, and mefA as the primary resistance genes in multidrug-resistant group A streptococci in southern Sweden, highlighting the emergence of novel MLS resistance subphenotypes.
Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones.
The study identified the tetM gene as responsible for tetracycline resistance in Mycoplasma hominis and Ureaplasma urealyticum.
Tetracycline-resistance genes of Clostridium perfringens, Clostridium septicum and Clostridium sordellii isolated from cattle affected with malignant edema.
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Transfer of the pheromone-inducible plasmid pCF10 among Enterococcus faecalis microorganisms colonizing the intestine of mini-pigs.
The study characterizes the tetracycline resistance determinant tet(M) encoded on the pheromone-inducible plasmid pCF10, which was transferred between Enterococcus faecalis strains in the intestinal tract of mini-pigs.
The identification of a tetracycline resistance gene tet(M), on a Tn916-like transposon, in the Bacillus cereus group.
The identification of a tetracycline resistance gene tet(M), on a Tn916-like transposon, in the Bacillus cereus group.
Characterization of the tetracycline resistance plasmid pMD5057 from Lactobacillus plantarum 5057 reveals a composite structure.
A clonal lineage of VanA-type Enterococcus faecalis predominates in vancomycin-resistant Enterococci isolated in New Zealand.
The study identifies the VanA-type Enterococcus faecalis as the predominant clonal lineage in vancomycin-resistant Enterococci (VRE) isolated in New Zealand, highlighting the presence of vanA, ermB, and tet(M) genes associated with glycopeptide, macrolide, and tetracycline resistance, respectively.
Molecular characterization of tet(M) genes in Lactobacillus isolates from different types of fermented dry sausage.
The study identifies the tet(M) gene as the primary tetracycline resistance gene in Lactobacillus isolates from fermented dry sausages, highlighting its prevalence and genetic diversity.
Phenotypic and molecular characterization of tetracycline- and erythromycin-resistant strains of Streptococcus pneumoniae.
The study identified tet(M), erm(B), mef(A), and mef(E) as the primary genes responsible for tetracycline and erythromycin resistance in Streptococcus pneumoniae strains.
Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus.
The study describes a multiplex PCR assay for detecting nine clinically relevant antibiotic resistance genes in Staphylococcus aureus, including mecA, aacA-aphD, erm(A), erm(C), tetK, tetM, and vat genes, which confer resistance to methicillin, aminoglycosides, macrolides, lincosamides, streptogramins, tetracyclines, and quinupristin-dalfopristin.
Characterization of the tet(M) determinant of Tn916: evidence for regulation by transcription attenuation.
The study characterizes the tet(M) determinant of Tn916, identifying it as a tetracycline resistance gene regulated by transcriptional attenuation.
Characterization of the tet(M) determinant of Tn916: evidence for regulation by transcription attenuation.
Characterization of the tet(M) determinant of Tn916: evidence for regulation by transcription attenuation.
Six-month multicenter study on invasive infections due to group B streptococci in Argentina.
The study identified several AMR genes in group B streptococci, including aac(6')-aph(2"), mefA, ermTR, tetM, and tetO, which confer resistance to aminoglycosides, macrolides, and tetracyclines. These genes were experimentally validated through PCR and susceptibility testing.
Effect of tetracycline on transfer and establishment of the tetracycline-inducible conjugative transposon Tn916 in the guts of gnotobiotic rats.
The study characterizes the tetracycline resistance gene tet(M) associated with the conjugative transposon Tn916, which confers resistance to tetracycline in Enterococcus faecalis.
Prevalence and molecular characterization of tetracycline resistance in Enterococcus isolates from food.
The study identified tet(M), tet(L), and tet(S) genes as the primary tetracycline resistance mechanisms in Enterococcus isolates from food, with tet(M) being the most prevalent.
Tn2009, a Tn916-like element containing mef(E) in Streptococcus pneumoniae.
Phenotypic and molecular characteristics of Streptococcus agalactiae isolates recovered from milk of dairy cows in Brazil.
The study identified erm(B), tet(O), and tet(M) as the primary genes responsible for erythromycin and tetracycline resistance in Streptococcus agalactiae isolates from dairy cows in Brazil.
Antibiotic Resistance and Virulence Traits of Enterococci Isolated from Baylough, an Irish Artisanal Cheese
The study identified tetracycline resistance genes (tet(M) and tet(L)) and an erythromycin resistance gene (erm(B)) in Enterococcus strains isolated from an Irish artisanal cheese.
Characterisation of viridans group streptococci with different levels of Tet(M)-mediated tetracycline resistance.
Characterisation of viridans group streptococci with different levels of Tet(M)-mediated tetracycline resistance.
Characterisation of viridans group streptococci with different levels of Tet(M)-mediated tetracycline resistance.
Detection of tet(M) Gene from Raw Milk by Rapid DNA Extraction Followed by a Two-Step PCR with Nested Primers
The study developed a rapid DNA extraction method combined with a two-step PCR using nested primers to detect the tet(M) gene in raw milk, demonstrating high sensitivity and speed.
Distribution of tetracycline resistance genes in genotypically related and unrelated multiresistant Acinetobacter baumannii strains from different European hospitals.
The study identified tet(A), tet(B), and tet(M) as tetracycline resistance genes in Acinetobacter baumannii strains, with tet(B) additionally conferring resistance to minocycline. The efflux gene adeB was present in all strains regardless of tet gene status.
Phenotypic and genotypic characteristics of Streptococcus porcinus isolated from human sources.
The study identified the presence of tet(M) and tet(O) genes in tetracycline-resistant Streptococcus porcinus isolates from human sources, highlighting the role of these genes in tetracycline resistance.
Development and Application of Real-Time PCR Assays for Quantification of Genes Encoding Tetracycline Resistance
The study developed and validated real-time PCR assays to quantify ten major classes of tetracycline resistance genes (tet) in microbiome samples, revealing significant differences in tet gene abundance between bovine and swine manures, with swine manures showing higher levels. Composting significantly reduced tet gene abundance.
Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef(I).
The study identified a novel mef gene subclass, mef(I), in pneumococci with efflux-mediated erythromycin resistance. It also characterized the presence of tet(M) and tet(O) genes contributing to tetracycline resistance in certain isolates.
Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef(I).
Simultaneous detection of nine antibiotic resistance-related genes in Streptococcus agalactiae using multiplex PCR and reverse line blot hybridization assay.
The study developed a multiplex PCR and reverse line blot hybridization assay to detect nine antibiotic resistance-related genes in Streptococcus agalactiae, including erm(B), erm(A/TR), mef(A/E), tet(M), tet(O), aphA-3, aad-6, int-Tn, and mreA. These genes were found to be associated with resistance to macrolides, lincosamides, streptogramin B, tetracyclines, and aminoglycosides.
Diagnostic PCR analysis of the occurrence of methicillin and tetracycline resistance genes among Staphylococcus aureus isolates from phase 3 clinical trials of tigecycline for complicated skin and skin structure infections.
The study identified the presence of the mecA gene, which confers methicillin resistance, and tetracycline resistance genes tet(M) and tet(K) in Staphylococcus aureus isolates from phase 3 clinical trials of tigecycline.
The presence of a conjugative Gram-positive Tn2009 in Gram-negative commensal bacteria.
New variants of the tet(M) gene in Clostridium difficile clinical isolates harbouring Tn916-like elements.
New variants of the tet(M) gene in Clostridium difficile clinical isolates harbouring Tn916-like elements.
New variants of the tet(M) gene in Clostridium difficile clinical isolates harbouring Tn916-like elements.
Identification of Tn5397-like and Tn916-like transposons and diversity of the tetracycline resistance gene tet(M) in enterococci from humans, pigs and poultry.
Identification of Tn5397-like and Tn916-like transposons and diversity of the tetracycline resistance gene tet(M) in enterococci from humans, pigs and poultry.
Identification of Tn5397-like and Tn916-like transposons and diversity of the tetracycline resistance gene tet(M) in enterococci from humans, pigs and poultry.
Identification of Tn5397-like and Tn916-like transposons and diversity of the tetracycline resistance gene tet(M) in enterococci from humans, pigs and poultry.
Identification of Tn5397-like and Tn916-like transposons and diversity of the tetracycline resistance gene tet(M) in enterococci from humans, pigs and poultry.
Identification of Tn5397-like and Tn916-like transposons and diversity of the tetracycline resistance gene tet(M) in enterococci from humans, pigs and poultry.
Ecology of antibiotic resistance genes: characterization of enterococci from houseflies collected in food settings.
The study identified tet(M) and erm(B) as the primary tetracycline and erythromycin resistance genes in enterococci from houseflies in food settings.
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome.
Identification and sequence of a tet(M) tetracycline resistance determinant homologue in clinical isolates of Escherichia coli.
The study identifies and characterizes the tet(M) tetracycline resistance determinant in clinical isolates of Escherichia coli, demonstrating its functionality and mobility via conjugation.
Identification and sequence of a tet(M) tetracycline resistance determinant homologue in clinical isolates of Escherichia coli.
Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland.
The study identified the tet(M) gene as the primary resistance determinant in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland, with the majority of isolates harboring Tn916-family transposons containing this gene.
Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene.
The study identifies and characterizes genetic elements carrying the erm(B) gene, which confers resistance to macrolides, lincosamides, and streptogramin B, and its association with the tet(M) gene, which confers tetracycline resistance in Streptococcus pyogenes.
Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene.
Isolation and molecular characterization of antibiotic-resistant lactic acid bacteria from poultry and swine meat products.
The study identified tetracycline resistance genes (tet(M)), erythromycin resistance genes (erm(B)), and penicillin resistance gene (blaZ) in lactic acid bacteria isolated from poultry and swine meat products.
Methicillin-resistant Staphylococcus aureus ST398 in humans and animals, Central Europe.
The study identifies methicillin-resistant Staphylococcus aureus ST398 carrying resistance genes mecA, ermA, ermC, tetM, and aph2"-aac6', indicating resistance to penicillin, erythromycin, clindamycin, oxytetracycline, and gentamicin respectively.
Monitoring and Source Tracking of Tetracycline Resistance Genes in Lagoons and Groundwater Adjacent to Swine Production Facilities over a 3-Year Period
The study identified and characterized seven tetracycline resistance genes (tet(M), tet(O), tet(Q), tet(W), tet(C), tet(H), and tet(Z)) in lagoons and groundwater near swine production facilities over a 3-year period. These genes were consistently detected in groundwater and lagoon samples, with varying frequencies and concentrations depending on the location and sampling time.
Genetic diversity among Enterococcus faecalis.
The study identifies various AMR genes in Enterococcus faecalis, including blaZ, ermB, tetM, and vanA, which confer resistance to beta-lactams, macrolides, tetracyclines, and glycopeptides, respectively.
Evaluating the effects of chlortetracycline on the proliferation of antibiotic-resistant bacteria in a simulated river water ecosystem.
The study found that high concentrations of chlortetracycline (CTC) selected for increased tetracycline resistance in aerobic bacterial populations, with a greater diversity of tet resistance genes detected in the high-CTC chemostat compared to low-CTC and control chemostats.
Molecular epidemiology and distribution of serotypes, surface proteins, and antibiotic resistance among group B streptococci in Italy.
The study identified erythromycin resistance genes erm(B), erm(A), and mef(A), and tetracycline resistance gene tet(M) in group B streptococci (GBS) in Italy. Erythromycin resistance was predominantly associated with serotype V and the PFGE type 1/CC1 group.
Influx of enterococci and associated antibiotic resistance and virulence genes from ready-to-eat food to the human digestive tract.
The study identifies the tet(M) gene as a major tetracycline resistance determinant in enterococci isolated from ready-to-eat food, highlighting its potential role in the transmission of antibiotic resistance to the human digestive tract.
Demonstration of in vivo transfer of doxycycline resistance mediated by a novel transposon.
Antibiotic resistance of enterococci in American bison (Bison bison) from a nature preserve compared to that of Enterococci in pastured cattle.
The study identified ermB and tetO as the primary erythromycin and tetracycline resistance genes in enterococci from both bison and cattle, with tetM also found in some bison isolates. Ciprofloxacin resistance was noted but not linked to specific mutations.
erm(B)-Carrying Elements in Tetracycline-Resistant Pneumococci and Correspondence between Tn1545 and Tn6003.
The study identified and characterized erm(B)-carrying transposons in tetracycline-resistant pneumococci, showing that Tn1545 and Tn6003 have similar resistance gene combinations, including erm(B), tet(M), and aphA-3. It also revealed that Tn6002 was the most common transposon among the isolates.
Phenotypic and molecular assessment of antimicrobial resistance in Lactobacillus paracasei strains of food origin.
Three L. paracasei strains from cheese showed acquired resistance to tetracycline and/or erythromycin, linked to the presence of tet(M), tet(W), and erm(B) genes.
Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains.
The study identifies several AMR genes and mutations associated with resistance to penicillin, tetracycline, and fluoroquinolones in Neisseria gonorrhoeae, including bla TEM-1, tet (M), and various mutations in penA, penB, mtrR, ponA, rpsJ, gyrA, and parC.
Spread of Streptococcus suis sequence type 7, China.
A novel transposon, Tn6009, composed of a Tn916 element linked with a Staphylococcus aureus mer operon.
The study identifies a novel transposon, Tn6009, which contains the tet(M) gene linked to the Staphylococcus aureus mer operon, conferring resistance to tetracycline and mercury.
A novel transposon, Tn6009, composed of a Tn916 element linked with a Staphylococcus aureus mer operon.
Transfer of antibiotic resistance marker genes between lactic acid bacteria in model rumen and plant environments.
The study demonstrates the transfer of antibiotic resistance marker genes, specifically erm(B) and tet(M), between lactic acid bacteria in both in vitro and in vivo models, highlighting the potential for horizontal gene transfer in natural environments.
Concurrent Titration and Determination of Antibiotic Resistance in Ureaplasma Species with Identification of Novel Point Mutations in Genes Associated with Resistance.
The study identified a novel deletion in the L4 protein of an erythromycin-resistant Ureaplasma isolate and a point mutation in the ParC subunit of a ciprofloxacin-resistant isolate. Additionally, the tetM gene was found in a tetracycline-resistant isolate.
Structural characterization of Tn916-like element in Streptococcus parauberis serotype II strains isolated from diseased Japanese flounder.
Characterization of the Tn916 conjugative transposon in a food-borne strain of Lactobacillus paracasei.
The study identifies the tet(M) gene associated with the Tn916 conjugative transposon in tetracycline-resistant Lactobacillus paracasei strains, which can transfer to Enterococcus faecalis.
Horizontal transfer of the tetracycline resistance gene tetM mediated by pCF10 among Enterococcus faecalis in the house fly (Musca domestica L.) alimentary canal.
Horizontal transfer of the tetracycline resistance gene tetM mediated by pCF10 among Enterococcus faecalis in the house fly (Musca domestica L.) alimentary canal.
Diversity of the tetracycline resistance gene tet(M) and identification of Tn916- and Tn5801-like (Tn6014) transposons in Staphylococcus aureus from humans and animals.
Intra- and interspecies conjugal transfer of Tn916-like elements from Lactococcus lactis in vitro and in vivo.
The study demonstrates the intra- and interspecies conjugal transfer of Tn916-like elements carrying the tet(M) gene from Lactococcus lactis to Enterococcus faecalis, highlighting the potential for horizontal gene transfer of tetracycline resistance.
Characterization of methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococcus spp. isolated from US West Coast public marine beaches.
The study identified methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococcus (MRCoNS) isolates carrying resistance genes erm(A), tet(M), and tet(K) from marine environments along the US West Coast.
Antibiotic resistance genes in the vaginal microbiota of primates not normally exposed to antibiotics.
The study identified tetracycline resistance genes (tet(M), tet(W), tet(Q)) and erythromycin resistance genes (ermB, ermF) in the vaginal microbiota of primates not typically exposed to antibiotics, indicating the presence of antibiotic resistance genes in these animals despite limited antibiotic exposure.
Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).
The study identifies several AMR genes and mutations in the MRSA strain TW20, including mecA for methicillin resistance, qacA for antiseptic resistance, Tn554 and ermA1 for streptomycin and erythromycin resistance, BlaZ for beta-lactam resistance, TetM for tetracycline resistance, and DfrG for trimethoprim resistance. Additionally, a point mutation in GyrA (Ser84Leu) confers quinolone resistance.
Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).
Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).
Human group A streptococci virulence genes in bovine group C streptococci.
The study identified antimicrobial resistance genes erm(B), erm(A), linB, tet(M), and tet(O) in bovine group C streptococci, indicating their potential role in multidrug resistance and horizontal gene transfer.
Skin lesion caused by ST398 and ST1 MRSA, Spain.
The study identifies multiple antimicrobial resistance genes and mutations in MRSA strains causing a skin lesion in a Spanish patient, including mecA, tetK, tetL, tetM, ermA, ermB, ermC, msrA, aph(2')-acc(6'), ant(4')-Ia, aph(3')-III, and dfrK, along with quinolone resistance mutations in grlA and gyrA.
The genome of Streptococcus mitis B6--what is a commensal?
The study identifies multiple antibiotic resistance genes in Streptococcus mitis B6, including tetM, aacA-aphD, aphA, sat, and aadE, which confer resistance to tetracycline and aminoglycosides. Additionally, a mutation in rpoB (H486N) was found to confer rifampicin resistance.
Whole genome analysis of a livestock-associated methicillin-resistant Staphylococcus aureus ST398 isolate from a case of human endocarditis.
The study identifies tetracycline resistance genes tet(M) and tet(K), as well as the methicillin resistance gene mecA in the ST398 MRSA isolate S0385, highlighting its multidrug resistance profile.
Multiple copies of functional, Tet(M)-encoding Tn916-like elements in a clinical Enterococcus faecium isolate.
Three functional copies of Tn916-like elements containing tet(M) were identified in the clinical Enterococcus faecium isolate C68, conferring resistance to tetracycline and minocycline.
Relatedness of human and animal Clostridium difficile PCR ribotype 078 isolates determined on the basis of multilocus variable-number tandem-repeat analysis and tetracycline resistance.
The study identified the tet(M) gene as the primary tetracycline resistance mechanism in Clostridium difficile PCR ribotype 078 isolates, with all tetracycline-resistant strains containing a Tn916-like transposon carrying this gene.
Cloning and nucleotide sequence of a chromosomally encoded tetracycline resistance determinant, tetA(M), from a pathogenic, methicillin-resistant strain of Staphylococcus aureus.
Cloning and nucleotide sequence of a chromosomally encoded tetracycline resistance determinant, tetA(M), from a pathogenic, methicillin-resistant strain of Staphylococcus aureus.
Diversity and mobility of integrative and conjugative elements in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis.
The study identified various AMR genes including erm(B), linB, lnuD, tet(M), tet(S), and tet(O) associated with resistance to macrolides, lincosamides, and tetracyclines in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis.
Empyema caused by MRSA ST398 with atypical resistance profile, Spain.
The study reports MRSA ST398 isolates with resistance to beta-lactams, tetracycline, clindamycin, ciprofloxacin, and levofloxacin, carrying mecA, tetK, tetM, and vga(A) genes, along with gyrA(S84L) and parC(S80F) mutations.
The antimicrobial resistance patterns and associated determinants in Streptococcus suis isolated from humans in southern Vietnam, 1997-2008.
The study reports the presence and expression of tet(L) in Streptococcus suis strains and highlights the co-expression of multiple tetracycline resistance genes contributing to high MIC levels against tetracycline.
Heterogeneity of Tn5253-like composite elements in clinical Streptococcus pneumoniae isolates.
Insects in confined swine operations carry a large antibiotic resistant and potentially virulent enterococcal community.
The study identifies tet(M) and erm(B) as the most common resistance genes in enterococci from insects and swine feces, highlighting their role in multidrug resistance.
Rapid pneumococcal evolution in response to clinical interventions.
Rapid pneumococcal evolution in response to clinical interventions.
Clonal spread of Streptococcus pyogenes emm44 among homeless persons, Rennes, France.
The study identifies the tet(M) gene as the cause of tetracycline resistance in a clonal outbreak of Streptococcus pyogenes emm44 among homeless individuals in Rennes, France.
Slaughterhouse pigs are a major reservoir of Streptococcus suis serotype 2 capable of causing human infection in southern Vietnam.
The study identified tetracycline resistance genes tet(M), tet(O), and tet(L), and erythromycin resistance gene erm(B) in Streptococcus suis serotype 2 strains isolated from slaughterhouse pigs in southern Vietnam.
Genetic resistance elements carrying mef subclasses other than mef (A) in Streptococcus pyogenes
The study identifies various mef subclasses (mef(E), mef(I), mef(A/E), and a novel mef) associated with resistance genes (tet(M), tet(O), and catQ) in Streptococcus pyogenes, highlighting the diversity of genetic elements involved in macrolide and tetracycline resistance.
Antibiotic resistance determinants in the interplay between food and gut microbiota.
The study identifies tetracycline resistance genes tet(M) and tet(W), and erythromycin resistance gene erm(B) in Lactobacillus paracasei strains isolated from Italian dairy and meat products.
Antibiotic resistance and molecular epidemiology of Staphylococcus aureus in Nigeria.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from Nigeria, including aacA-aphD, ermA, mecA, tetK, and tetM, which confer resistance to gentamicin, erythromycin, oxacillin, and tetracycline. High levels of resistance to tetracycline and trimethoprim/sulfamethoxazole were observed.
High levels of recombination among Streptococcus pneumoniae isolates from the Gambia.
The study identified the tetM gene as a common tetracycline resistance determinant among Streptococcus pneumoniae isolates from the Gambia.
The increase of methicillin-resistant Staphylococcus aureus (MRSA) and the presence of an unusual sequence type ST49 in slaughter pigs in Switzerland.
The study identifies the presence of methicillin-resistant Staphylococcus aureus (MRSA) in slaughter pigs in Switzerland, highlighting the emergence of the unusual sequence type ST49. It reports various AMR genes such as mecA, blaZ, tet(M), tet(K), erm(A), erm(C), ant(9)-Ia, str, dfr(G), and vga(A)v, which confer resistance to β-lactams, tetracycline, macrolides, lincosamides, streptogramins B, spectinomycin, streptomycin, trimethoprim, and tiamulin.
Nucleotide sequence of the tet(M) gene of Tn916.
Nucleotide sequence of the tet(M) gene of Tn916.
The gut as reservoir of antibiotic resistance: microbial diversity of tetracycline resistance in mother and infant.
The study identified various tetracycline resistance genes, including tet(M), tet(L), erm(T), tet(W), tet(O), and tet(X), in the gut microbiota of a mother and her infant. It also discovered a novel composite transposon, Tn 6079, carrying tet(M), tet(L), and erm(T) in the infant's gut, highlighting the potential for horizontal gene transfer and maternal transmission of antibiotic resistance.
Persistent, toxin-antitoxin system-independent, tetracycline resistance-encoding plasmid from a dairy Enterococcus faecium isolate.
The study identifies the tetracycline resistance genes tet(M) and tet(L) on a 19.6-kb plasmid from a dairy Enterococcus faecium isolate, demonstrating their functionality and transmissibility.
Acquired antibiotic resistance: are we born with it?
The study identified the presence of tetracycline resistance gene tet (M), erythromycin resistance gene ermB, sulfonamide resistance gene sul2, and beta-lactam resistance gene bla TEM in the gut microbiota of infants, indicating that antibiotic resistance genes are present in the human gut microbiota from an early age.
SNP diversity of Enterococcus faecalis and Enterococcus faecium in a South East Queensland waterway, Australia, and associated antibiotic resistance gene profiles.
The study identified aac(6')-aph(2') as a gene conferring gentamicin resistance in Enterococcus faecalis and Enterococcus faecium, tet(M) as a determinant of tetracycline resistance, and mutations in gyrA and pbp5 genes associated with ciprofloxacin and ampicillin resistance, respectively.
Antibiotic resistance in primary and persistent endodontic infections.
The study identified bla TEM-1, cfx A, tet M, tet W, and tet Q as the most prevalent antibiotic resistance genes in endodontic infections. bla TEM-1 was more prevalent in primary infections, while tet M remained unchanged after treatment. Vancomycin resistance genes were not detected.
Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone.
The study identified genic differences in the blp bacteriocin locus and erythromycin resistance genes among PMEN1 strains, contributing to variations in virulence and antibiotic resistance.
Functional metagenomics reveals previously unrecognized diversity of antibiotic resistance genes in gulls.
The study identified numerous antibiotic resistance (AR) genes in gulls, including both known and previously undescribed ones. It highlights the significant diversity of AR genes in gulls, emphasizing their potential role in spreading resistance genes between human and environmental habitats.
Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic.
The study characterizes several tetracycline resistance genes, including tet(M), tet(K), tet(B), tet(A), and tet(X), demonstrating their roles in conferring resistance to tetracycline and related antibiotics.
Novel conjugative transferable multiple drug resistance plasmid pAQU1 from Photobacterium damselae subsp. damselae isolated from marine aquaculture environment.
The study identifies several AMR genes on the plasmid pAQU1, including bla CARB-9 -like, floR, mef (A)-like, sul2, tet (M), and tet (B), which confer resistance to various antibiotics such as carbenicillin, chloramphenicol, florfenicol, erythromycin, sulfonamide, and tetracycline.
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.
Antibiotic resistance genes & susceptibility patterns in staphylococci.
The study identified several antibiotic resistance genes in staphylococcal isolates, including mecA for methicillin resistance, aac(6')/aph(2"), aph(3')-IIIa, and ant(4')-Ia for gentamicin resistance, ermA, ermB, ermC, and msrA for erythromycin resistance, tetK and tetM for tetracycline resistance, and blaZ for penicillin resistance.
ermA, ermC , tetM and tetK are essential for erythromycin and tetracycline resistance among methicillin-resistant Staphylococcus aureus strains isolated from a tertiary hospital in Malaysia.
The study identified ermA, ermC, tetM, and tetK as essential genes for erythromycin and tetracycline resistance in MRSA strains from a Malaysian hospital.
Molecular basis for different levels of tet(M) expression in Streptococcus pneumoniae clinical isolates.
DNA microarray profiling of a diverse collection of nosocomial methicillin-resistant staphylococcus aureus isolates assigns the majority to the correct sequence type and staphylococcal cassette chromosome mec (SCCmec) type and results in the subsequent identification and characterization of novel SCCmec-SCCM1 composite islands.
The study identifies and characterizes novel SCCmec-SCCM1 composite islands in MRSA isolates, highlighting the presence of various AMR genes such as blaZ, erm(A), aadD, qacA, qacC, merA, merB, fosB, sdrM, aacA-aphD, far1 (fusB), Q6GD50 (fusC), and cat-pC194 (pMC524).
Comparative genomics of the Staphylococcus intermedius group of animal pathogens.
The study identifies several antibiotic resistance genes in S. pseudintermedius ED99, including bla operon, aad6-sat4-aphA-3, ermB, and tetM, which confer resistance to beta-lactams, aminoglycosides, macrolides, lincosamides, streptogramins, and tetracyclines.
Different antibiotic resistance and sporulation properties within multiclonal Clostridium difficile PCR ribotypes 078, 126, and 033 in a single calf farm.
The study identified multiple variants of the tetracycline resistance gene tet(M) in Clostridium difficile strains from a single calf farm, with varying resistance profiles to tetracycline and erythromycin.
Structural basis for TetM-mediated tetracycline resistance.
The study elucidates the structural basis of TetM-mediated tetracycline resistance, revealing how TetM interacts with the ribosome to displace tetracycline and confer resistance.
Molecular characteristics of erythromycin-resistant Streptococcus pneumoniae from pediatric patients younger than five years in Beijing, 2010.
The study identified the ermB and tetM genes as the primary factors contributing to erythromycin and tetracycline resistance in Streptococcus pneumoniae isolates from pediatric patients in Beijing. Additionally, the mec gene was found to be associated with erythromycin resistance.
High diversity of genetic lineages and virulence genes in nasal Staphylococcus aureus isolates from donkeys destined to food consumption in Tunisia with predominance of the ruminant associated CC133 lineage.
The study identified various AMR genes in nasal Staphylococcus aureus isolates from donkeys, including blaZ, erm(A), erm(C), tet(M), and fusC, which confer resistance to penicillin, erythromycin, tetracycline, and fusidic acid.
Long-term exposure to antibiotics has caused accumulation of resistance determinants in the gut microbiota of honeybees.
The study identifies eight tetracycline resistance genes (tetB, tetC, tetD, tetH, tetL, tetY, tetM, and tetW) in the gut microbiota of honeybees, highlighting the accumulation of resistance determinants due to long-term antibiotic exposure in beekeeping practices.
A novel approach to associate genes and mutations with drug resistance phenotypes by comparative analysis of fully sequenced bacterial strains
The study identified several AMR genes and mutations associated with drug resistance in S. aureus, including blaZ, mecA, tet, tetM, aacA-aphD, and mutations in rpsL, rpsJ, grlA, and gyrA.
Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis.
The study identified tetracycline resistance genes tet(M) and tet(O), the erythromycin resistance gene erm(B), and the streptomycin resistance gene aadA in Streptococcus canis isolates, highlighting the presence of antimicrobial resistance mechanisms in this species.
Changes in enterococcal populations and related antibiotic resistance along a medical center-wastewater treatment plant-river continuum.
The study identified the presence of erm(B), mef(A), and tet(M) genes in Enterococcus faecium isolates from hospital and retirement home effluents, contributing to macrolide and tetracycline resistance.
Tetracycline resistance genes acquired at birth
The study identified tetracycline resistance genes (tet(M), tet(O), tet(Q), and tet(W)) in the microbiota of newborns and their mothers, highlighting differences in gene prevalence based on delivery mode.
Antimicrobial susceptibility profiles of human and piglet Clostridium difficile PCR-ribotype 078.
The study identified tet(M) and erm(B) as key resistance genes in C. difficile PCR-ribotype 078 isolates, along with gyrA mutations contributing to fluoroquinolone resistance.
Comparison of Multi-Drug Resistant Environmental Methicillin-Resistant Staphylococcus aureus Isolated from Recreational Beaches and High Touch Surfaces in Built Environments.
The study identified multiple antibiotic resistance genes in environmental MRSA isolates, including aadD, erm(A), erm(C), msr(A), tet(K), and tet(M), which confer resistance to kanamycin, erythromycin, clindamycin, and tetracycline. These genes were found in a high proportion of the isolates, indicating that environmental MRSA can serve as reservoirs for antibiotic resistance genes.
Isolation and characterization of Staphylococcus aureus strains from a Paso del Norte dairy.
Antibiotic administration routes significantly influence the levels of antibiotic resistance in gut microbiota.
The study shows that oral administration of antibiotics leads to higher levels of antibiotic resistance gene pools in the gut microbiota compared to intravenous administration. Specifically, the tet(M) gene and blaCMY-2 gene were found to confer resistance to tetracycline and ampicillin, respectively.
Evidence of antimicrobial resistance-conferring genetic elements among pneumococci isolated prior to 1974.
The study identified two Tn 916-like, tet(M)-containing elements in pneumococci isolated in 1967 and 1968, and a novel composite ICE, ICE Sp PN1, in a pneumococcus isolated in 1972. These elements contained genes conferring resistance to tetracycline and chloramphenicol.
Pharmacodynamics of doxycycline and tetracycline against Staphylococcus pseudintermedius: proposal of canine-specific breakpoints for doxycycline.
The study identifies tetracycline resistance genes tet(M), tet(K), and tet(O) in Staphylococcus pseudintermedius isolates and proposes canine-specific breakpoints for doxycycline susceptibility testing.
Novel pseudo-staphylococcal cassette chromosome mec element (ψSCCmec57395) in methicillin-resistant Staphylococcus pseudintermedius CC45.
The study identifies a novel pseudo-staphylococcal cassette chromosome mec element (ψSCCmec57395) in methicillin-resistant Staphylococcus pseudintermedius CC45, along with various AMR genes such as mecA, blaZ, aac(6')-Ie–aph(2')-Ia, aph(3')-III, ant(6)-Ia, sat4, erm(B), tet(M), dfr(G), and cat pC221. Additionally, fluoroquinolone resistance was linked to specific mutations in gyrA and grlA.
Staphylococcus aureus colonization of healthy military service members in the United States and Afghanistan.
The study identified several AMR genes in MRSA and MSSA isolates, including ermC, tetK, tetM, blaZ, msrA, and ermA, which confer resistance to clindamycin, tetracycline, penicillin, and erythromycin. These findings highlight the genetic basis of antimicrobial resistance in S. aureus isolates from military personnel in the US and Afghanistan.
Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element.
The study identified the tetracycline resistance gene tetM in camel-derived Streptococcus agalactiae, which was associated with tetracycline resistance and located on a Tn916-like element.
Antimicrobial susceptibility and antibiotic resistance gene transfer analysis of foodborne, clinical, and environmental Listeria spp. isolates including Listeria monocytogenes.
The study identified the tet(M) gene as the primary cause of tetracycline resistance in Listeria isolates, along with dfrA, dfrD, and dfrG genes responsible for trimethoprim resistance. Additionally, the transferability of these resistance genes via conjugative transposons and plasmids was demonstrated.
Drug-resistant and hospital-associated Enterococcus faecium from wastewater, riverine estuary and anthropogenically impacted marine catchment basin.
The study identified multiple AMR genes in Enterococcus faecium isolates from wastewater, marine outfalls, and river environments, including pbp5, aac(6')-Ie-aph(2"), ant(6')-Ia, tet(M), and tet(L). Mutations in gyrA (S84R) were associated with ciprofloxacin resistance.
Diversity of antibiotic resistance genes and staphylococcal cassette chromosome mec elements in faecal isolates of coagulase-negative staphylococci from Nigeria.
The study identified several antibiotic resistance genes, including aac(6')-aph(2"), ermC, msrA, tetK, tetM, and mecA, in faecal isolates of coagulase-negative staphylococci from Nigeria. These genes were associated with resistance to gentamicin, erythromycin, and tetracycline, as well as methicillin resistance.
Complete genome sequencing and comparative analysis of the linezolid-resistant Enterococcus faecalis strain DENG1
Characterization of Staphylococcus aureus Responses to Spermine Stress.
The study identifies tetM as a gene specifically induced by spermine and tetracycline in Staphylococcus aureus, although it does not confer resistance to spermine.
Various pAQU plasmids possibly contribute to disseminate tetracycline resistance gene tet(M) among marine bacterial community.
The study identifies pAQU group plasmids that can transfer the tetracycline resistance gene tet(M) to E. coli, highlighting their potential role in spreading antibiotic resistance in marine environments.
Antibiotic resistance in lactic acid bacteria isolated from some pharmaceutical and dairy products.
The study identified the presence of tet(M) and erm(B) genes in lactic acid bacteria (LAB) isolated from pharmaceutical and dairy products, indicating tetracycline and erythromycin resistance, respectively.
Molecular analysis of vanA outbreak of Enterococcus faecium in two Warsaw hospitals: the importance of mobile genetic elements.
The study identified the vanA gene as the primary determinant of vancomycin and teicoplanin resistance in Enterococcus faecium outbreaks. Additional resistance genes such as erm(B), tet(M), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, and aad6 were also characterized, contributing to multidrug resistance.
Epidemiology and molecular characterization of methicillin-resistant Staphylococcus aureus nasal carriage isolates from bovines.
The study identified multiple AMR genes in MRSA isolates from bovines, including blaZ, blaI, blaR, tetM, ermC, aacA-aphD, aadD, aphA3, cat, sdrM, and fosB, which confer resistance to penicillin, tetracycline, erythromycin, gentamicin, kanamycin, chloramphenicol, and fosfomycin.
Detection and linkage to mobile genetic elements of tetracycline resistance gene tet(M) in Escherichia coli isolates from pigs.
The study identifies the tetracycline resistance gene tet(M) in Escherichia coli isolates from pigs, showing its presence on plasmids and its potential for horizontal transfer from enterococci.
Phenotypic and genotypic analysis of Clostridium difficile isolates: a single-center study.
The study identified mutations in gyrA and gyrB genes associated with ciprofloxacin resistance, and the presence of tetM and ermB genes conferring resistance to tetracycline and clindamycin, respectively, in Clostridium difficile isolates.
Spread of Streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant Clone, Spain.
The study identifies the emergence of a multidrug-resistant Streptococcus pneumoniae serotype 8-ST63 clone in Spain, characterized by the presence of ermB and tetM genes, and mutations in parC and gyrA that confer resistance to fluoroquinolones.
Rapid Diagnostic Approaches for Antimicrobial Resistance
The paper discusses various rapid antimicrobial resistance testing methods, including molecular techniques like qPCR, DNA microarrays, Luminex xMAP, and next-generation sequencing (NGS), highlighting their roles in detecting resistance genes such as blaCTX-M, blaTEM, blaSHV, blaKPC, blaNDM, blaOXA-48, blaVIM, blaIMP, mecA, mecC, vanA, vanB, aacA-aphD, tetK, tetM, ermA, ermC, vatA, vatB, and vatC in different bacterial species.
Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011.
The study identifies tetracycline resistance determinant tetM and aminoglycoside resistance determinant aphA1 in Clostridium difficile 078 isolates from humans and pigs, indicating shared antimicrobial resistance mechanisms between human and animal strains.
Global phylogenomic analysis of nonencapsulated Streptococcus pneumoniae reveals a deep-branching classic lineage that is distinct from multiple sporadic lineages.
The study identifies tetM, ermB, and mefE as genes responsible for tetracycline and macrolide resistance in nonencapsulated Streptococcus pneumoniae isolates, highlighting the antibiotic resistance profile of the classic lineage ST344 and ST448.
Transfer of tetracycline resistance genes with aggregation substance in food-borne Enterococcus faecalis.
The study identified the presence of tet(L), tet(M), and tet(S) genes in food-borne Enterococcus faecalis isolates, highlighting their role in tetracycline resistance and the potential for horizontal gene transfer via aggregation substances and pheromone-mediated conjugation.
Detection of tetracycline resistance genes in bacteria isolated from fish farms using polymerase chain reaction.
The study identified tetracycline resistance genes tet(A), tet(M), and tet(S) in bacterial isolates from Iranian fish farms, with tet(S) being the most prevalent.
Unraveling antimicrobial resistance genes and phenotype patterns among Enterococcus faecalis isolated from retail chicken products in Japan.
The study identified several antimicrobial resistance genes in Enterococcus faecalis isolated from retail chicken products in Japan, including aac(6')-Ie-aph(2")-Ia, aph(3')-IIIa, ant(6)-Ia, tet(L), tet(M), tet(O), and erm(B). These genes were associated with resistance to various antibiotics such as kanamycin, gentamicin, streptomycin, dihydrostreptomycin, oxytetracycline, and erythromycin.
Population structure and antimicrobial resistance of invasive serotype IV group B Streptococcus, Toronto, Ontario, Canada.
The study identified ermTR and ermT genes associated with macrolide resistance, and tetM gene associated with tetracycline resistance in serotype IV group B Streptococcus strains.
Phage-mediated horizontal transfer of a Staphylococcus aureus virulence-associated genomic island.
The study demonstrates the phage-mediated transfer of the Staphylococcus aureus genomic island νSaβ, which includes the tetracycline resistance gene tetM and the chloramphenicol resistance gene cat.
Rampant Parasexuality Evolves in a Hospital Pathogen during Antibiotic Selection.
The study identifies deletions in the 5'-UTR of tetM that lead to constitutive overexpression of TetM, conferring tigecycline resistance in Enterococcus faecalis.
Effect of in-feed administration and withdrawal of tylosin phosphate on antibiotic resistance in enterococci isolated from feedlot steers.
The study found that tylosin phosphate administration increased the proportion of erythromycin and tylosin resistant enterococci, but withdrawal reduced their prevalence. The resistance was primarily mediated by the erm(B) gene and msrC gene.
Sampling and Pooling Methods for Capturing Herd Level Antibiotic Resistance in Swine Feces using qPCR and CFU Approaches.
The study identified several antibiotic resistance genes in swine fecal samples using qPCR, including tetracycline resistance genes (tet(A), tet(B), tet(C), tet(M), tet(O), tet(W)), erythromycin resistance genes (ermB, ermF), sulfonamide resistance genes (sulI, sulII), beta-lactam resistance genes (blaCTX-M-1 group, blaCMY-2, blaSHV family), and glycopeptide resistance gene (vanA).
Emergence of Serotype IV Group B Streptococcus Adult Invasive Disease in Manitoba and Saskatchewan, Canada, Is Driven by Clonal Sequence Type 459 Strains.
The study identified the tetracycline resistance gene tetM and the macrolide/lincosamide resistance gene ermTR in serotype IV Group B Streptococcus (GBS) strains, which are responsible for the emergence of invasive disease in Manitoba and Saskatchewan, Canada.
Haemophilus ducreyi Cutaneous Ulcer Strains Are Nearly Identical to Class I Genital Ulcer Strains.
The study found that Haemophilus ducreyi cutaneous ulcer (CU) strains are nearly identical to class I genital ulcer (GU) strains and are highly susceptible to antibiotics, including azithromycin. Resistance mechanisms in GU strains included beta-lactamase (blaTEM-1B) and tetracycline resistance genes (tet(B), tet(32), tet(M)).
In vitro antimicrobial susceptibility of Helcococcus kunzii and molecular analysis of macrolide and tetracycline resistance.
The study identified erm(TR) as a cause of high-level erythromycin resistance and tet(M) as a cause of tetracycline resistance in Helcococcus kunzii.
Housefly Larva Vermicomposting Efficiently Attenuates Antibiotic Resistance Genes in Swine Manure, with Concomitant Bacterial Population Changes.
The study found that housefly larva vermicomposting significantly reduces the abundance of tetracycline resistance genes (tet(M), tet(O), tet(Q), tet(W)) and increases the abundance of sulfonamide resistance genes (sul1, sul2) in swine manure. It also observed changes in the bacterial community structure, with a significant decrease in the diversity and richness of bacteria.
Genetic composition of invasive pneumococci recovered during 2008–2013
The study analyzed invasive pneumococcal disease (IPD) isolates from children before and after PCV13 implementation, focusing on strain distributions, resistance features, and genetic characteristics. Key findings include the significant reduction in PCV13-targeted serotypes and the identification of resistance mechanisms associated with specific serotypes and clonal complexes.
Characterization of mannitol-fermenting methicillin-resistant staphylococci isolated from pigs in Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant staphylococci isolated from pigs in Nigeria, including mecA, blaZ, erm(C), erm(B), str, tet(K), tet(M), tet(L), dfrG, dfrK, aacA/aphD, aphA3, cat pC221, and cat pC223. Additionally, a Ser84Leu mutation in the gyrA gene was found to confer ciprofloxacin resistance.
Antibiotic Resistance among Clinical Ureaplasma Isolates Recovered from Neonates in England and Wales between 2007 and 2013.
The study identified the tet(M) tetracycline resistance gene in three Ureaplasma isolates and ciprofloxacin resistance mutations in two isolates, highlighting low levels of antibiotic resistance among Ureaplasma species in England and Wales.
Nasal Carriage of Staphylococcus aureus : Frequency and Antibiotic Resistance in Healthy Ruminants.
The study identified the presence of antibiotic resistance genes blaZ, mecA, tetK, and tetM in Staphylococcus aureus isolates from healthy ruminants, highlighting the potential reservoir of antimicrobial-resistant S. aureus in nasal carriage.
A Livestock-Associated, Multidrug-Resistant, Methicillin-Resistant Staphylococcus aureus Clonal Complex 97 Lineage Spreading in Dairy Cattle and Pigs in Italy.
The study identifies multiple AMR genes in CC97 MRSA isolates from Italian dairy cattle and pigs, including erm(B), erm(C), vga(A), tet(K), tet(M), blaZ, and aacA-aphD, which confer resistance to various antibiotics such as erythromycin, clindamycin, tiamulin, tetracycline, penicillin, and aminoglycosides.
Persistence of Multi-Drug Resistance Plasmids in Sterile Water under Very Low Concentrations of Tetracycline.
The study shows that multi-drug resistance plasmids pAQU1 and IncFIB can persist in bacterial populations under very low selective pressure, including in non-culturable states. The plasmids retain their resistance genes, such as tet(M), tet(B), floR, mph(A)-like, mef(A)-like, and sul2, which confer resistance to tetracycline, florfenicol, macrolides, and sulfonamides.
Molecular detection of antimicrobial resistance in local isolates of Staphylococcus epidermidis from urinary tract infections in Faisalabad region of Pakistan.
The study identified multiple antimicrobial resistance genes in Staphylococcus epidermidis isolates from urinary tract infections in Pakistan, including tetM, tetK, aac(6')/aph(2"), aacA-aphD, ermA, blaZ, mecA, MeccA, and blaTEM-1, indicating widespread multidrug resistance.
Diversity and Evolution of the Tn5801-tet(M)-Like Integrative and Conjugative Elements among Enterococcus, Streptococcus, and Staphylococcus.
The study identifies various Tn5801-tet(M)-like elements in Enterococcus, Streptococcus, and Staphylococcus, highlighting the diversity and evolution of tetracycline resistance mechanisms.
Identification and antimicrobial resistance prevalence of pathogenic Escherichia coli strains from treated wastewater effluents in Eastern Cape, South Africa.
The study identified several AMR genes in E. coli isolates from wastewater effluents, including strA, aadA, catI, cmlA1, blaTEM, and various tetracycline resistance genes (tetA, tetB, tetC, tetD, tetK, tetM). These genes conferred resistance to multiple antibiotics such as streptomycin, gentamicin, chloramphenicol, ampicillin, and tetracycline.
Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline.
The study shows that the copresence of tet(K) and tet(M) in LA-MRSA CC398 enhances fitness during exposure to sublethal tetracycline concentrations, with tet(K) providing an additional fitness benefit.
Sequence-Based Characterization of Tn5801-Like Genomic Islands in Tetracycline-Resistant Staphylococcus pseudintermedius and Other Gram-positive Bacteria from Humans and Animals.
The study identified Tn5801-like genomic islands carrying the tetracycline resistance gene tet(M) in tetracycline-resistant Staphylococcus pseudintermedius isolates from pets and other Gram-positive bacteria. Two distinct Tn5801-like GI types were detected, highlighting the horizontal transfer of these elements between S. pseudintermedius and human pathogens.
Antimicrobial Resistance Mechanisms
The paper discusses various mechanisms of antibiotic resistance, including beta-lactamases like blaKPC, blaNDM, blaIMP, and blaVIM, which confer resistance to carbapenems. It also covers aminoglycoside modifying enzymes such as aac(6')-Ib and aac(6')-I, quinolone resistance proteins like qnr, tetracycline resistance genes such as tet(M) and tet(O), macrolide resistance genes like erm, mefA, and mefE, and efflux pump systems like mexAB-oprM and acrAB-tolC.
Molecular Epidemiology of Streptococcus pneumoniae Isolates from Children with Recurrent Upper Respiratory Tract Infections.
The study identified multiple AMR genes in Streptococcus pneumoniae isolates from children with recurrent upper respiratory tract infections, including erm(B), mef(E), tet(M), and cat pC194, which confer resistance to macrolides, tetracyclines, and chloramphenicol.
Characterisation of Phenotypic and Genotypic Antibiotic Resistance Profile of Enterococci from Cheeses in Turkey.
The study identified several antibiotic resistance genes in enterococci from Turkish cheeses, including ermB, tetM, aph(3')-IIIa, cat, and aac(6')-Ieaph(2")-Ia, which confer resistance to macrolides, lincosamides, streptogramin B, tetracycline, kanamycin, gentamicin, and chloramphenicol.
Lack of doxycycline antimalarial prophylaxis impact on Staphylococcus aureus tetracycline resistance.
The study found that tetracycline resistance in Staphylococcus aureus isolates from wounded military personnel was associated with the presence of tet(M) and tet(K) genes, but there was no significant association between doxycycline exposure and tetracycline resistance.
The Bacterial Mobile Resistome Transfer Network Connecting the Animal and Human Microbiomes.
The study identifies mobile antibiotic resistance genes (ARGs) in bacterial genomes and explores their transfer networks between animal and human microbiomes, highlighting the role of phylogeny and ecology in shaping the mobile resistome.
Shifts in the Clonal Distribution of Methicillin-Resistant Staphylococcus aureus in Kuwait Hospitals: 1992-2010.
The study identified various AMR genes in MRSA isolates from Kuwait hospitals, including aphA3, aacA-aphD, ermA, ermC, mupA, tetK, tetM, fusC, far1, msrA, mphC, sat, qacA, qacC, merA, merB, dfrS1, aadD, fosB, cat, sdrM, icaA, icaC, and icaD, which conferred resistance to multiple antibiotics.
Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes.
The study introduces SEER, a computational method for identifying sequence elements associated with bacterial phenotypes, including antibiotic resistance. It confirms known resistance mechanisms such as cat for chloramphenicol, tetM for tetracycline, and pbp genes for beta-lactam resistance, as well as identifies new potential factors related to S. pyogenes invasiveness.
More than 50% of Clostridium difficile Isolates from Pet Dogs in Flagstaff, USA, Carry Toxigenic Genotypes.
The study identified toxigenic Clostridium difficile isolates from pet dogs in Flagstaff, USA, highlighting their potential role as a source of community-acquired infections in humans.
Evaluating the mobility potential of antibiotic resistance genes in environmental resistomes without metagenomics.
The study identifies and characterizes the mobility potential of sul1 and tetM antibiotic resistance genes in environmental samples using a novel method involving Inverse PCR and long read sequencing.
Characterization and Comparative Overview of Complete Sequences of the First Plasmids of Pandoraea across Clinical and Non-clinical Strains.
The study characterizes plasmids from various Pandoraea strains, identifying several antibiotic resistance genes including beta-lactamases, tetracycline resistance genes, aminoglycoside resistance genes, fluoroquinolone resistance genes, macrolide resistance genes, chloramphenicol resistance genes, and lincomamide resistance genes.
Bacterial viruses enable their host to acquire antibiotic resistance genes from neighbouring cells.
The study demonstrates that prophages in Staphylococcus aureus can facilitate the transfer of antibiotic resistance genes from neighboring cells through a process called 'autotransduction.' Resistance genes such as ermB, cat, and tetM were successfully transferred.
Prevalence of colonization by methicillin-resistant Staphylococcus aureus ST398 in pigs and pig farm workers in an area of Catalonia, Spain.
The study found that all MRSA-ST398 isolates exhibited tetracycline resistance, with the tet(M) gene being responsible for this resistance.
Nosocomial Outbreak of Drug-Resistant Streptococcus pneumoniae Serotype 9V in an Adult Respiratory Medicine Ward.
The study identifies the presence of tetracycline resistance gene tetM, and macrolide resistance genes mefA and msrD in a nosocomial outbreak of drug-resistant Streptococcus pneumoniae serotype 9V.
Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections.
The study identified macrolide resistance genes mefA and erm in Streptococcus pyogenes isolates, highlighting the increasing prevalence of macrolide resistance in the Middle East.
Whole-Genome Analysis of Antimicrobial-Resistant and Extraintestinal Pathogenic Escherichia coli in River Water.
The study identified numerous antimicrobial resistance genes in Escherichia coli isolates from river water, highlighting the presence of multidrug-resistant and extraintestinal pathogenic strains. Key resistance genes included blaTEM-1, aac(3)-IId, qnrB7, and others.
Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014.
The study identifies the emergence of multidrug-resistant serotype 15A Streptococcus pneumoniae in the UK, highlighting the presence of resistance genes erm(B) and tet(M) associated with macrolide and tetracycline resistance, respectively.
Plasmid-mediated resistance to tetracyclines among Neisseria gonorrhoeae strains isolated in Poland between 2012 and 2013.
The study identified the presence of plasmid-mediated tetracycline resistance in Neisseria gonorrhoeae strains, primarily due to the tetM gene, with the Dutch type being more prevalent than the American type in Polish isolates.
Characterization of Methicillin-Resistant Staphylococcus aureus Isolated from Healthy Turkeys and Broilers Using DNA Microarrays.
The study identified several AMR genes in MRSA isolates from healthy turkeys and broilers, including ermA, ermB, ermC, tetK, tetM, lnuA, mphC, vgaA, aadD, aphA3, blaZ, blaI, blaR, and mecA. These genes conferred resistance to various antibiotics such as erythromycin, clindamycin, tetracycline, lincomycin, macrolides, streptogramins, tobramycin, neomycin, kanamycin, and beta-lactam antibiotics.
Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.).
The study identified various AMR genes and mutations in Enterococcus faecalis isolates from macaque cephalic implants, highlighting the presence of high-level aminoglycoside resistance, tetracycline resistance, and bacitracin resistance. These findings emphasize the complexity of AMR in clinical settings and the need for targeted antimicrobial strategies.
Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.).
The study identified various AMR genes and mutations in Enterococcus faecalis isolates from macaque cephalic implants, highlighting the presence of high-level aminoglycoside resistance, tetracycline resistance, and bacitracin resistance. These findings emphasize the complexity of AMR in clinical settings and the need for targeted antimicrobial strategies.
Interspecies transfer of vancomycin, erythromycin and tetracycline resistance among Enterococcus species recovered from agrarian sources.
The study identified the transfer of vancomycin, erythromycin, and tetracycline resistance genes among Enterococcus species, highlighting the potential for horizontal gene transfer in agrarian environments.
A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements.
The study identifies multiple AMR genes and mutations contributing to multidrug resistance in a Clostridium difficile lineage endemic to Costa Rican hospitals, including ermB, tetM, catD, aacA-aphD, and ant6-sat4-aphA-3, as well as gyrA and rpoB mutations.
mecA-related structure in methicillin-resistant coagulase-negative staphylococci from street food in Taiwan.
The study identified mecA and mecA Ss genes in methicillin-resistant coagulase-negative staphylococci (MRCoNS) from street food in Taiwan, along with several other resistance genes such as ermA, ermC, tet(M), tet(K), tet(O), and aac(6')-Ie-aph(2'')-Ia, which confer resistance to oxacillin, erythromycin, tetracycline, and gentamicin.
WGS to predict antibiotic MICs for Neisseria gonorrhoeae.
The study identifies various AMR genes and mutations in Neisseria gonorrhoeae that contribute to resistance against multiple antibiotics, including cefixime, penicillin, azithromycin, ciprofloxacin, and tetracycline. These findings are supported by WGS and multivariate linear regression models.
Region-specific diversification of the highly virulent serotype 1 Streptococcus pneumoniae.
The study identifies tetracycline resistance gene tetM and chloramphenicol resistance gene cat in serotype 1 Streptococcus pneumoniae isolates, highlighting regional variations in antimicrobial resistance profiles.
Bacteria from Animals as a Pool of Antimicrobial Resistance Genes.
The paper discusses the role of bacteria from animals as a reservoir of antimicrobial resistance genes, highlighting the presence of various AMR genes such as erm(B), tet(M), cfr, and others in different bacterial species, emphasizing their contribution to the spread of resistance.
Release and Constancy of an Antibiotic Resistance Gene in Seawater under Grazing Stress by Ciliates and Heterotrophic Nanoflagellates.
The study shows that the tetracycline resistance gene tet(M) is released into seawater under grazing stress by ciliates and heterotrophic nanoflagellates, and remains stable over time.
A Functional Metagenomic Analysis of Tetracycline Resistance in Cheese Bacteria.
The study identified four tetracycline resistance genes (tet(A), tet(L), tet(M), and tet(S)) in cheese bacteria using functional metagenomics.
High Prevalence of Macrolide-resistance and Molecular Characterization of Streptococcus pyogenes Isolates Circulating in China from 2009 to 2016.
The study identified high prevalence of macrolide resistance in Streptococcus pyogenes isolates in China, with erm(B) and mef(A/E) genes being the primary mechanisms. Tet(M) was the main determinant of tetracycline resistance, and mutations in gyrA and parC were associated with fluoroquinolone resistance.
Environmental surveillance identifies multiple introductions of MRSA CC398 in an Equine Veterinary Hospital in the UK, 2011-2016.
The study identified multiple introductions of MRSA CC398 in an equine veterinary hospital, with the predominant strain being CC398-IVa-t011. The isolates exhibited resistance to gentamicin (aacA-aphD), tetracycline (tetM and tetK), and other antibiotics. The study highlights the importance of environmental surveillance and infection control measures to prevent MRSA transmission.
Occurrence of the mcr-1 Colistin Resistance Gene and other Clinically Relevant Antibiotic Resistance Genes in Microbial Populations at Different Municipal Wastewater Treatment Plants in Germany.
The study identified the mcr-1 colistin resistance gene and several other clinically relevant antibiotic resistance genes, including ermB, tetM, CTX-M, CTX-M-32, blaTEM, and CMY-2, in wastewater treatment plant samples in Germany.
Transcriptional Response of Resistome to Composting and Its Implications for Antimicrobial Resistance Dissemination
The study identifies several tetracycline resistance genes (tetM, tetW, tetO, tetS), sulfonamide resistance genes (sulI, sulII), and others, showing their expression dynamics during composting and their association with microbial community shifts.
Association between selected antimicrobial resistance genes and antimicrobial exposure in Danish pig farms.
The study identified several antimicrobial resistance (AMR) genes, including ermB, ermF, sulI, sulII, tet(M), tet(O), and tet(W), and examined their association with antimicrobial exposure in Danish pig farms. The results showed complex relationships between antimicrobial exposure and AMR gene levels, with varying correlations depending on the specific gene and antimicrobial class.
Molecular characterization of vancomycin-resistant Staphylococcus aureus strains isolated from clinical samples: A three year study in Tehran, Iran.
The study identified vancomycin-resistant Staphylococcus aureus (VRSA) strains carrying the vanA gene, along with multiple resistance genes such as mecA, ermA, ermB, ermC, msrA, msrB, tetM, ant(4')-Ia, aac(6')-Ie/aph(2'')-Ia, and aph(3')-IIIa. These strains exhibited high-level resistance to vancomycin and other antibiotics.
Nasal and pharyngeal carriage of methicillin-resistant Staphylococcus sciuri among hospitalised patients and healthcare workers in a Serbian university hospital.
Population and Whole Genome Sequence Based Characterization of Invasive Group A Streptococci Recovered in the United States during 2015.
The study identified several AMR genes and mutations in invasive group A streptococci, including ermT, ermB, ermTR, tetM, lsaC, mef, msrD, and mutations in ParC and GyrA that confer resistance to macrolides, tetracycline, and fluoroquinolones.
Assessment of antibiotic susceptibility in Lactobacillus isolates from chickens.
The study identified several tetracycline, macrolide, and aminoglycoside resistance genes in Lactobacillus isolates from chickens, highlighting the presence of resistance mechanisms in these bacteria.
Detection of tetracycline resistance genes, aminoglycoside modifying enzymes, and coagulase gene typing of clinical isolates of Staphylococcus aureus in the Southwest of Iran.
The study identified aac(6')-Ie-aph(2"), aph(3')-IIIa, ant(4')-Ia, tetK, and tetM as the primary genes responsible for aminoglycoside and tetracycline resistance in Staphylococcus aureus isolates from the Southwest of Iran.
Characterization of Streptococcus pneumoniae isolates from Austrian companion animals and horses.
The study identified multidrug-resistant Streptococcus pneumoniae isolates from rats, which exhibited resistance to tetracycline, erythromycin, clindamycin, chloramphenicol, and trimethoprim-sulfamethoxazole. Resistance genes tet(M), erm(B), and cat pC194 were detected, along with mutations in the dfr gene associated with trimethoprim resistance.
Detection of Antibiotic Resistance and Resistance Genes in Enterococci Isolated from Sucuk, a Traditional Turkish Dry-Fermented Sausage.
The study identified several AMR genes including ermB, ermC, gyrA, tetM, tetL, and vanA in Enterococcus isolates from Sucuk, highlighting the potential for these bacteria to serve as reservoirs of antibiotic resistance genes.
Characterization of Streptococcus pyogenes from Animal Clinical Specimens, Spain.
The study characterizes 15 Streptococcus pyogenes isolates from animals in Spain, identifying macrolide resistance genes mef A and erm B, and tetracycline resistance genes tet M and tet O. Most isolates exhibited the M phenotype for macrolide resistance, while some showed cMLS B or iMLS B phenotypes.
Community-acquired infection with hypervirulent Clostridium difficile isolates that carry different toxin and antibiotic resistance loci: a case report.
The study identified the presence of ermB and tetM genes in hypervirulent Clostridium difficile isolates, indicating resistance to erythromycin/clindamycin and tetracycline, respectively.
Rapid in situ imaging and whole genome sequencing of biofilm in neonatal feeding tubes: A clinical proof of concept.
The study identified several AMR genes in Enterococcus faecalis and Enterobacter hormaechei isolated from neonatal feeding tubes, including lsaA (macrolide resistance), tetM (tetracycline resistance), blaACT-15 (beta-lactam resistance), and fosA (fosfomycin resistance).
Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand.
The study identified various AMR genes and mutations in Neisseria gonorrhoeae isolates from New Zealand, including bla TEM-1B, mtrR, ponA, penB, gyrA, parC, rpsJ, and 23S rRNA mutations, contributing to resistance against penicillin, ciprofloxacin, tetracycline, and azithromycin.
Phylogeny and antimicrobial resistance in Neisseria gonorrhoeae isolates from Rio de Janeiro, Brazil.
The study characterized 116 Neisseria gonorrhoeae isolates from Rio de Janeiro, Brazil, highlighting high resistance rates to penicillin, tetracycline, ciprofloxacin, and azithromycin. Key resistance mechanisms included chromosomal mutations in ponA, porB, rpsJ, gyrA, parC, and rrl, as well as plasmid-mediated resistance via blaTEM-1 and tetM. Promoter and coding region mutations in mtrR were also linked to azithromycin resistance.
Whole-genome sequencing reveals transmission of gonococcal antibiotic resistance among men who have sex with men: an observational study.
The study identified the transmission of antibiotic-resistant Neisseria gonorrhoeae strains between men who have sex with men, highlighting the role of specific genes and mutations in conferring resistance to various antibiotics.
Subtype-Specific Selection for Resistance to Fluoroquinolones but Not to Tetracyclines Is Evident in Campylobacter jejuni Isolates from Beef Cattle in Confined Feeding Operations in Southern Alberta, Canada.
The study identifies tetO as the primary tetracycline resistance gene in Campylobacter jejuni isolates from beef cattle and highlights gyrA mutations, particularly Thr86Ile, as a major cause of fluoroquinolone resistance.
High diversity and abundance of cultivable tetracycline-resistant bacteria in soil following pig manure application.
The study identifies several tetracycline resistance genes (tet B, tet L, tet Z, tet M, tet O, and tet X) in cultivable tetracycline-resistant bacteria from pig manure and soil, highlighting the diversity and abundance of these genes following pig manure application.
Comparison of antimicrobial resistance genes in feedlots and urban wastewater.
The study identified various antimicrobial resistance genes in feedlots and urban wastewater, highlighting the prevalence of sulfonamide, tetracycline, macrolide, fluoroquinolone, and β-lactam resistance genes in different environments.
Antibiotic residues in liquid manure from swine feedlot and their effects on nearby groundwater in regions of North China.
The study identified antibiotic resistance genes (ARGs) such as qnrA, sulI, sulII, tetG, tetM, tetO, and intI1 in liquid manure from swine feedlots and their effects on nearby groundwater. These genes were found to be associated with fluoroquinolone, sulfonamide, and tetracycline resistance.
Genetic Determinants of Tetracycline Resistance in Clinical Streptococcus pneumoniae Serotype 1 Isolates from Niger.
Clinical Streptococcus pneumoniae serotype 1 isolates from Niger exhibited high tetracycline resistance (77.4%) primarily due to the presence of the tet(M) gene within a defective Tn5253-like transposon. One isolate was also resistant to chloramphenicol due to the presence of a cat gene.
Host range of antibiotic resistance genes in wastewater treatment plant influent and effluent.
The study identified the bacterial hosts of four resistance-associated genes (tetM, int1, qacEΔ1, and blaOXA-58) in wastewater treatment plant influent and effluent using epicPCR, revealing variations in host range between the two stages.
Antimicrobial Resistance in Streptococcus spp.
The paper discusses the prevalence and mechanisms of antimicrobial resistance in Streptococcus species, particularly focusing on macrolide, lincosamide, and tetracycline resistance. Key genes identified include erm(B), erm(A), lnuB, lnuD, mefA, mefE, msr, tet(B), tet(K), tet(L), tet(M), tet(O), and tet(S).
Various Profiles of tet Genes Addition to tet(X) in Riemerella anatipestifer Isolates From Ducks in China.
The study identified and characterized multiple tetracycline resistance genes, including tet(A), tet(B), tet(M), tet(O), tet(O/W/32/O), tet(Q), and tet(X), in Riemerella anatipestifer isolates from ducks in China. The tet(X) gene was found to be the primary mechanism of tetracycline resistance.
Changes in Macrolide Resistance Among Group A Streptococci in Serbia and Clonal Evolution of Resistant Isolates.
The study identified the genes mefA, ermB, ermTR, and tetM as responsible for macrolide and tetracycline resistance in Group A Streptococci in Serbia.
Increasing macrolide resistance among Streptococcus agalactiae causing invasive disease in non-pregnant adults was driven by a single capsular-transformed lineage, Portugal, 2009 to 2015.
The study identifies a significant increase in macrolide resistance among Streptococcus agalactiae isolates causing invasive disease in non-pregnant adults in Portugal, primarily linked to the expansion of a specific capsular-transformed lineage (CC1) harboring resistance genes such as erm(B), erm(TR), erm(T), mef(E), tet(M), tet(O), and tet(L).
Molecular characterization of serogroup 19 Streptococcus pneumoniae in the Czech Republic in the post-vaccine era.
The study identified the presence of the ermB and tetM genes in serogroup 19 Streptococcus pneumoniae isolates, which conferred resistance to erythromycin and tetracycline, respectively. Additionally, mutations in penicillin-binding protein (PBP) genes were associated with penicillin resistance in 19F isolates.
Combination Therapy Strategies Against Multiple-Resistant Streptococcus Suis.
The study identifies several AMR genes in multidrug-resistant Streptococcus suis isolates, including tetM, lnuB, erm(B), tetO, tetL, and aph3′, which confer resistance to tetracycline, clindamycin, erythromycin, and aminoglycosides.
Interplay of a non-conjugative integrative element and a conjugative plasmid in the spread of antibiotic resistance via suicidal plasmid transfer from an aquaculture Vibrio isolate.
The study identifies the plasmid pSEA1 and the integrative element Tn 6283, which carry various antibiotic resistance genes including tet(M), mef(C), mph(G), sul2, catII, and bla, facilitating the spread of antibiotic resistance in aquatic environments.
The draft genomes and investigation of serotype distribution, antimicrobial resistance of group B Streptococcus strains isolated from urine in Suzhou, China.
The study identified several AMR genes in GBS isolates from urine in Suzhou, including tetM, ermB, mefE, lnuB, and others, associated with resistance to tetracycline, erythromycin, clindamycin, and fluoroquinolones.
Genomic Comparison of Highly Virulent, Moderately Virulent, and Avirulent Strains From a Genetically Closely-Related MRSA ST239 Sub-lineage Provides Insights Into Pathogenesis.
The study identifies dfrG, a gene encoding a trimethoprim-resistant dihydrofolate reductase, as a factor contributing to trimethoprim resistance in TW20, CMRSA6, and CMRSA3. M92 lacks this gene and is susceptible to trimethoprim.
Occurrence and Distribution of Tetracycline Antibiotics and Resistance Genes in Longshore Sediments of the Three Gorges Reservoir, China.
The study identified the presence of tetracycline resistance genes tet(A), tet(C), and tet(M) in longshore sediments of the Three Gorges Reservoir, with varying abundances across different zones and seasons.
Phylogenomics of Staphylococcus aureus CC5: Evolution, Resistance, and Virulence
The study identifies key AMR genes such as ermA, aacA-aphD, and tetM associated with resistance to macrolides, aminoglycosides, and tetracyclines in CC5-MRSA strains, highlighting convergent genomic changes during clade expansions.
Extended antibiotic treatment in salmon farms select multiresistant gut bacteria with a high prevalence of antibiotic resistance genes.
The study identifies several AMR genes, including floR, fexA, and various tetracycline resistance genes (tetA, tetB, tetE, tetH, tetL, tetM, tet34, tet35), associated with resistance to florfenicol and oxytetracycline in gut bacteria from salmon farms. These genes were found in multiple bacterial species, highlighting the widespread nature of AMR in aquatic environments.
Nucleotide sequence of the tetM tetracycline resistance determinant of the streptococcal conjugative shuttle transposon Tn1545.
Nucleotide sequence of the tetM tetracycline resistance determinant of the streptococcal conjugative shuttle transposon Tn1545.
Emerging of antimicrobial resistance in staphylococci isolated from clinical and food samples in Algeria.
The study identified several AMR genes in staphylococci from clinical and food samples in Algeria, including blaZ, mecA, tetM, tetK, aacA-aphD, and ermC. These genes conferred resistance to penicillin, methicillin, tetracycline, gentamicin, and erythromycin.
Critical steps in clinical shotgun metagenomics for the concomitant detection and typing of microbial pathogens.
The study characterizes various AMR genes involved in resistance to multiple antibiotics, including beta-lactams, aminoglycosides, macrolides, tetracyclines, and others, in different bacterial species such as Staphylococcus aureus, Enterococcus faecium, and Serratia marcescens.
Occurrence and characterization of methicillin-resistant Staphylococcus pseudintermedius in successive parturitions of bitches and their puppies in two kennels in Italy.
The study identified multiple methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains in two Italian kennels, highlighting the presence of various resistance mechanisms including beta-lactam, aminoglycoside, macrolide, tetracycline, and chloramphenicol resistance genes.
Antimicrobial Resistance Profiles in Enterococcus spp. Isolates From Fecal Samples of Wild and Captive Black Capuchin Monkeys (Sapajus nigritus) in South Brazil.
The study identified the presence of antimicrobial resistance genes msrC, tet(M), and tet(L) in Enterococcus spp. isolates from wild and captive black capuchin monkeys in South Brazil, indicating the spread of resistance mechanisms in these bacterial populations.
Antimicrobial Resistance in Lactobacillus Species: A Genomic and Phenotypic Analysis
The study identifies various tetracycline, erythromycin, chloramphenicol, and aminoglycoside resistance genes in Lactobacillus species, highlighting their potential role in antimicrobial resistance and horizontal gene transfer.
Identification and antibiotic susceptibility of lactobacilli isolated from turkeys.
The study identified several tetracycline, macrolide, and lincosamide resistance genes in turkey-derived lactobacilli, including tetL, tetM, tetW, ermB, ermC, lnuA, aadE, ant(6)-Ia, cat, and lsaE. These genes were associated with resistance to tetracycline, erythromycin, lincomycin, streptomycin, chloramphenicol, and tiamulin.
Molecular basis for the emergence of a new hospital endemic tigecycline-resistant Enterococcus faecalis ST103 lineage.
The study identifies rpsJ and tetM as key contributors to tigecycline resistance in Enterococcus faecalis ST103 lineage, with specific mutations in these genes linked to resistance mechanisms.
Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris.
Sarecycline shows reduced activity against aerobic enteric Gram-negative bacteria and anaerobes compared to doxycycline and minocycline. It exhibits low spontaneous mutation frequencies against C. acnes, S. aureus, and S. epidermidis. Resistance mechanisms in S. aureus include tet(K), tet(M), and tet(38).
Prediction of the intestinal resistome by a three-dimensional structure-based method.
The study predicts 6,095 antibiotic resistance determinants (ARDs) in the human intestinal microbiota using a three-dimensional structure-based method called pairwise comparative modelling (PCM). Experimental validation of 71 predicted ARDs showed that they conferred resistance to various antibiotics, including beta-lactams, aminoglycosides, tetracyclines, macrolides, quinolones, sulfonamides, trimethoprim, fosfomycin, and glycopeptides.
Distribution of Transferable Antibiotic Resistance Genes in Laboratory-Reared Edible Mealworms (Tenebrio molitor L.).
The study identified tetracycline resistance genes (tet(M), tet(K), tet(S)), the MLS B resistance gene erm(B), and the aac-aph gene in laboratory-reared mealworms, indicating the presence of transferable antibiotic resistance genes in edible insects.
Characterization of Erythromycin and Tetracycline Resistance in Lactobacillus fermentum Strains.
The study identified erythromycin resistance genes erm(B) and erm(C) and tetracycline resistance genes tet(K) and tet(M) in Lactobacillus fermentum strains. None of the strains were able to transfer these resistance genes to other bacteria via conjugation.
Determination of copy number and circularization ratio of Tn916-Tn1545 family of conjugative transposons in oral streptococci by droplet digital PCR.
The study characterizes the tetracycline resistance gene tet(M) associated with Tn916-Tn1545 conjugative transposons in oral streptococci using droplet digital PCR.
Nosocomial outbreak of multi-resistant Streptococcus pneumoniae serotype 15A in a centre for chronic pulmonary diseases.
The study identifies the presence of tetM and ermB genes in multi-resistant Streptococcus pneumoniae serotype 15A, contributing to resistance against tetracycline, macrolides, and lincosamides.
Investigation of the Dominant Microbiota in Ready-to-Eat Grasshoppers and Mealworms and Quantification of Carbapenem Resistance Genes by qPCR.
The study quantified the presence of carbapenem resistance genes (bla OXA-48, bla NDM-1, and bla VIM) in ready-to-eat mealworms and grasshoppers from various countries, revealing varying frequencies of these genes in different samples.
The Prevalence of Colistin Resistant Strains and Antibiotic Resistance Gene Profiles in Funan River, China.
The study identified mcr-1 and mcr-3 genes as the primary colistin resistance genes in the Funan River, along with other resistance genes such as sul1, sul2, aac(6')-Ib-cr, bla CTX-M, tetM, ermB, qnrS, and aph(3')-IIIa. These genes were found in various bacterial species, highlighting the presence of multidrug-resistant strains in the river.
Turning the Tide against Antibiotic Resistance by Evaluating Novel, Halogenated Phenazine, Quinoline, and NH125 Compounds against Ureaplasma Species Clinical Isolates and Mycoplasma Type Strains.
The study identified the tet(M) gene as a tetracycline resistance determinant in Ureaplasma parvum isolates, highlighting its role in reducing susceptibility to tetracycline.
Characterization of a new transferable MDR plasmid carrying the pbp5 gene from a clade B commensal Enterococcus faecium.
IS26-Flanked Composite Transposon Tn6539 Carrying the tet(M) Gene in IncHI2-Type Conjugative Plasmids From Escherichia coli Isolated From Ducks in China.
The study identified a novel composite transposon Tn6539 carrying the tet(M) gene in IncHI2-type conjugative plasmids from E. coli isolates from ducks in China. The transposon is flanked by two IS26 elements in opposite orientations and facilitates the horizontal transfer of tet(M).
Nasal Resistome Development in Infants With Cystic Fibrosis in the First Year of Life.
The study identified various antimicrobial resistance genes in the nasal microbiome of infants with cystic fibrosis, including beta-lactamases, chloramphenicol efflux pumps, tetracycline resistance proteins, and enzymes involved in folic acid synthesis inhibition.
ICESsuHN105, a Novel Multiple Antibiotic Resistant ICE in Streptococcus suis Serotype 5 Strain HN105.
The study identifies a novel integrative conjugative element (ICE), ICESsuHN105, carrying multiple antibiotic resistance genes in Streptococcus suis serotype 5 strain HN105, contributing to its multidrug resistance phenotype.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
Identification of polysaccharide capsules among extensively drug-resistant genitourinary Haemophilus parainfluenzae isolates.
The study identifies novel AMR genes and mutations in XDR H. parainfluenzae isolates, including catS, mef(E), tet(M), and tet(B) for resistance to chloramphenicol, macrolides, tetracycline, and co-trimoxazole, respectively. Mutations in PBP3, GyrA, ParC, ParE, rplD, and DHFR were also found to confer resistance to β-lactams, fluoroquinolones, and co-trimoxazole.
Genetic Diversity Analysis of Methicillin-resistant Staphylococcus aureus Strains Isolated from Intensive Care Unit in Iran.
The study identified various AMR genes in MRSA isolates from Iranian ICUs, including genes conferring resistance to aminoglycosides, macrolides, tetracycline, and mupirocin.
Independent Microevolution Mediated by Mobile Genetic Elements of Individual Clostridium difficile Isolates from Clade 4 Revealed by Whole-Genome Sequencing.
The study identified multiple antimicrobial resistance genes, including aac(6')-Ib, ermB, tetM, and catD, in Clostridium difficile isolates from clade 4, highlighting the role of mobile genetic elements in the evolution of multidrug resistance.
Global Population Structure and Evolution of Clostridioides difficile ST11 and ST258 Lineages
The study identifies tetracycline resistance genes tetM and tet-44, along with the erythromycin resistance gene ermB, in C. difficile ST11 and ST258 lineages, highlighting their role in antimicrobial resistance.
Agricultural Origins of a Highly Persistent Lineage of Vancomycin-Resistant Enterococcus faecalis in New Zealand.
The study identifies the ST108 lineage of vancomycin-resistant Enterococcus faecalis as having an agricultural origin, with multiple resistance genes including vanA, ermB, tetL, tetM, and bcr operon components contributing to its persistence in New Zealand.
Manure and Doxycycline Affect the Bacterial Community and Its Resistome in Lettuce Rhizosphere and Bulk Soil.
The study identified the tetracycline resistance gene tetA(P) as being highly enriched in manure-treated soil and rhizosphere, particularly in doxycycline-treated bulk soil, indicating its potential as a marker for soil contamination by antibiotic-resistant bacteria and antibiotics.
Antimicrobial Resistance, Virulence Determinants, and Biofilm Formation of Enterococcus Species From Ready-to-Eat Seafood.
The study identified various antimicrobial resistance genes including ermA, ermB, ermC, mphC, vanA, vanB, tetA, and tetM in Enterococcus species isolated from ready-to-eat seafood, indicating the presence of multidrug-resistant strains.
Microbial Diversity and Antimicrobial Resistance Profile in Microbiota From Soils of Conventional and Organic Farming Systems.
The study identified several antibiotic resistance genes in soil microbiota from conventional and organic farming systems, including genes conferring resistance to beta-lactams, aminoglycosides, tetracyclines, and rifampicin. The primary resistance mechanisms were attributed to efflux pumps, particularly RND and ABC transporters.
A global to local genomics analysis of Clostridioides difficile ST1/RT027 identifies cryptic transmission events in a northern Arizona healthcare network.
The study identified several AMR genes and mutations in C. difficile ST1 isolates from northern Arizona, including cdeA, tetM, ermB, dfrF, and vanG, along with the gyrA Thr82Ile mutation associated with fluoroquinolone resistance.
Diverse Commensal Escherichia coli Clones and Plasmids Disseminate Antimicrobial Resistance Genes in Domestic Animals and Children in a Semirural Community in Ecuador.
The study identified various antimicrobial resistance (AMR) genes in commensal Escherichia coli isolates from children and domestic animals in a semirural community in Ecuador. These genes included blaTEM-1B, dfrA8, qnrB19, strA, strB, tetA, tetB, sul1, sul2, and others, contributing to resistance against multiple antibiotics such as ampicillin, trimethoprim, tetracycline, and sulfamethoxazole. The research highlights the role of plasmids in disseminating these AMR genes and emphasizes the complexity of AMR transmission in such environments.
Emergence of multidrug resistance and extensive drug resistance among enterococcal clinical isolates in Egypt.
The study identified several AMR genes in enterococcal isolates, including aac(6')-Ie-aph(2'')-Ia, ant(6')-Ia, ermB, msrA/B, tetK, tetL, tetM, vanB, vanC1, and optrA, which confer resistance to various antibiotics such as gentamicin, streptomycin, macrolides, lincosamides, tetracyclines, vancomycin, and linezolid.
Antibiotic Resistance of E. coli Isolated From a Constructed Wetland Dominated by a Crow Roost, With Emphasis on ESBL and AmpC Containing E. coli.
The study identified bla ctx-M and bla cmy-2 genes as major contributors to extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase resistance in E. coli isolates from a constructed wetland dominated by a crow roost. Tetracycline resistance was primarily mediated by tet (A), tet (B), and tet (M), while streptomycin resistance was linked to strA, strB, and aadA. Sulfamethoxazole/trimethoprim resistance was associated with the sul1 gene.
Penicillin-Binding Protein Typing, Antibiotic Resistance Gene Identification, and Molecular Phylogenetic Analysis of Meropenem-Resistant Streptococcus pneumoniae Serotype 19A-CC3111 Strains in Japan.
The study identified the presence of ermB, mefE, and tetM genes in meropenem-resistant Streptococcus pneumoniae serotype 19A-CC3111 strains in Japan, contributing to erythromycin and tetracycline resistance.
Occurrence and Characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Quarter Milk Samples From Dairy Cows in Germany.
This study identified 10 LA-MRSA isolates from dairy cows in Germany, all belonging to clonal complex CC398. These isolates exhibited resistance to methicillin, tetracycline, and macrolides/lincosamides, with the presence of mecA, blaZ, tet(K), tet(M), erm(A), and spc genes.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance in Neisseria gonorrhoeae: a Cross-Sectional Study of Isolates Recovered from Routine Urine Cultures in a High-Incidence Setting.
The study identified bla TEM-1b as a key determinant of penicillin resistance and tet (M) as a key determinant of tetracycline and doxycycline resistance in Neisseria gonorrhoeae isolates. Mutations in gyrA and parC were associated with quinolone resistance, while rpsJ V57M and mtrR promoter mutations contributed to tetracycline and azithromycin resistance, respectively.
Identification and molecular epidemiology of methicillin resistant Staphylococcus pseudintermedius strains isolated from canine clinical samples in Argentina.
The study identified various AMR genes in methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates from Argentina, including mecA, blaZ, ermB, dfrG, aph(3')-III, ant(6)-Ia, tetM, and aac(6')-Ie-aph(2')-Ia. Mutations in gyrA (S84L) and grlA (S80I) were associated with ciprofloxacin resistance.
Characteristics of methicillin-resistant Staphylococcus aureus from broiler farms in Germany are rather lineage- than source-specific.
The study identified multiple AMR genes in MRSA isolates from German broiler farms, including tet(K), tet(L), tet(M), erm(B), vga(A), dfrK, spc, and cat(pC221), which confer resistance to tetracycline, MLS B antibiotics, tiamulin, trimethoprim, spectinomycin, and chloramphenicol, respectively.
Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990-2017.
The study characterizes the antimicrobial resistance profiles of Staphylococcus aureus clinical isolates in Malaysia, highlighting the presence of mecA gene conferring beta-lactam resistance and erm gene contributing to MLSB resistance.
Pneumococcal carriage among children under five in Accra, Ghana, five years after the introduction of pneumococcal conjugate vaccine.
The study identified the presence of the tet(M) and ermB genes in Streptococcus pneumoniae isolates, which confer resistance to tetracycline and erythromycin, respectively.
Dissemination prevention of antibiotic resistant and facultative pathogenic bacteria by ultrafiltration and ozone treatment at an urban wastewater treatment plant.
The study analyzed the effectiveness of ultrafiltration and ozone treatment in reducing antibiotic resistance genes (ARGs) and facultative pathogenic bacteria in wastewater. It identified several ARGs, including sul1, blaTEM, tetM, CTX-M, CTX-M-32, blaOXA-48, blaVIM, CMY-2, vanA, mcr-1, blaNDM, ermB, and intl1, which were found to be prevalent in the wastewater. Both ultrafiltration units showed significant reduction in these ARGs and pathogenic bacteria, whereas ozone treatment was less effective.
Microbiological and clinical characteristics of Streptococcus gallolyticus subsp. pasteurianus infection in China.
The study characterizes the AMR genes and mutations in Streptococcus gallolyticus subsp. pasteurianus isolates from China, identifying erm(B), erm(A), erm(T), mef(A/E), tet(L), tet(O), and tet(M) as major contributors to erythromycin, clindamycin, and tetracycline resistance.
Hospital-based Surveillance Provides Insights Into the Etiology of Pediatric Bacterial Meningitis in Yaoundé, Cameroon, in the Post-Vaccine Era.
The study identified several antibiotic resistance genes in Streptococcus pneumoniae isolates, including catQ, folA, folP, tetM, mef, and penicillin-binding proteins, indicating resistance to chloramphenicol, trimethoprim, tetracycline, erythromycin, and penicillin.
Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci.
The study demonstrates the use of CRISPR-Cas9 delivered via conjugative plasmids to selectively deplete antibiotic resistance genes, specifically ermB and tetM, from Enterococcus faecalis populations in vitro and in vivo.
Antimicrobial Resistance Mechanisms in Antibiotic-Producing Bacteria and Pathogens
The paper discusses various antimicrobial resistance mechanisms in antibiotic-producing bacteria and pathogens, focusing on genes and mutations that confer resistance to different classes of antibiotics, including beta-lactams, aminoglycosides, tetracyclines, chloramphenicol, macrolides, and others.
Prevalence of Various Vaccine Candidate Proteins in Clinical Isolates of Streptococcus pneumoniae: Characterization of the Novel Pht Fusion Proteins PhtA/B and PhtA/D.
The study identified the prevalence of various vaccine candidate proteins in clinical isolates of Streptococcus pneumoniae, including the novel Pht fusion proteins PhtA/B and PhtA/D. It also characterized resistance mechanisms such as erm(B), mef(A/E), tet(M), and mutations in pbp1a, pbp2x, and pbp2b contributing to macrolide, tetracycline, and penicillin resistance.
Conjugative Gene Transfer between Nourished and Starved Cells of Photobacterium damselae ssp. damselae and Escherichia coli.
The study identified the tet(M) gene on the plasmid pAQU1 in Photobacterium damselae ssp. damselae, which confers tetracycline resistance and is involved in conjugative horizontal gene transfer.
Horizontal gene transfer contributes to virulence and antibiotic resistance of Vibrio harveyi 345 based on complete genome sequence analysis.
The study identified 25 antibiotic resistance genes in Vibrio harveyi 345, including genes for tetracycline (tetm, tetb), fluoroquinolone (qnrs), trimethoprim (dfra17), sulfonamide (sul2), and others, highlighting the role of horizontal gene transfer in its multidrug resistance.
Molecular characteristics and virulence gene profiles of Staphylococcus aureus isolates in Hainan, China.
The study identified ermC, tetK, and tetM as the primary genes responsible for erythromycin and tetracycline resistance in Staphylococcus aureus isolates from Hainan, China.
Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure.
The study identifies silenced antibiotic resistance genes in Staphylococcus aureus, highlighting the prevalence of transient antibiotic resistance due to mutations that inactivate resistance genes, leading to apparent susceptibility but potential re-emergence of resistance.
Novel spa and Multi-Locus Sequence Types (MLST) of Staphylococcus Aureus Samples Isolated from Clinical Specimens in Korean.
The study identified novel spa types and MLST types in methicillin-resistant Staphylococcus aureus (MRSA) isolates, along with antibiotic resistance genes such as mecA, TEM, aac(6')-aph(2"), ermA, and tetM, indicating multidrug resistance.
Manure Application Did Not Enrich Antibiotic Resistance Genes in Root Endophytic Bacterial Microbiota of Cherry Radish Plants.
The study found that manure application increased the occurrence of antibiotic resistance genes (ARGs) in the rhizosphere and phyllosphere of cherry radish, but not in the endophytic bacterial microbiota of the root, which is the edible part of the plant.
Characteristics of a Colistin-Resistant Escherichia coli ST695 Harboring the Chromosomally-Encoded mcr-1 Gene.
The study identifies the chromosomally-encoded mcr-1 gene in a colistin-resistant E. coli ST695 strain, along with various other resistance genes such as bla NDM-1, aadA1, aadA2, aph(3')-Ia, aph(3')-VI, rmtB, cmlA1, floR, tet(A), tet(M), dfrA12, oqxA, oqxB, qnrS1, mph(A), bla TEM-105, and bla TEM-1B, contributing to its multidrug-resistant phenotype.
Genotypic diversity of Streptococcus suis and the S. suis -like bacterium Streptococcus ruminantium in ruminants.
The study identified several antibiotic resistance genes in Streptococcus ruminantium isolates, including genes conferring resistance to tetracycline, streptomycin, erythromycin, kanamycin, and chloramphenicol. These genes were located in genomic islands and showed similarities to integrative conjugative elements.
Complex Class 1 Integron in a Clinical Escherichia coli Strain From Vietnam Carrying Both mcr-1 and bla (NDM-1).
The study identifies a multidrug-resistant E. coli strain carrying both mcr-1 and bla NDM-1, highlighting the co-existence of colistin and carbapenem resistance genes in Vietnam.
Resistome metagenomics from plate to farm: The resistome and microbial composition during food waste feeding and composting on a Vermont poultry farm.
The study identified 50 unique antibiotic resistance genes (ARGs) in food waste, compost, and farm products, with a focus on aminoglycoside, tetracycline, and macrolide resistance. Key ARGs included aph(6)-1d, lmrD, mefA, mel, abeM, abeS, adeF, adeG, adeI, adeJ, adeK, emrD, sul2, tetH, tetM, tetO, tetW, and tetX, which were found in various samples and showed resistance to multiple drug classes.
Unexpected relationships between frequency of antimicrobial resistance, disease phenotype and emm type in group A Streptococcus.
The study identifies specific AMR genes such as tet(M), erm(B), mef(A), msr(D), tet(O), erm(A), ant(6)-Ia, aph(3')-III, and erm(T) associated with resistance to tetracycline, erythromycin, clindamycin, and aminoglycosides in group A Streptococcus (GAS) strains. These genes are linked to high-frequency resistance in certain emm types, particularly emm11, emm75, emm77, and emm92, which are overrepresented in invasive GAS infections.
Metagenomic identification of severe pneumonia pathogens in mechanically-ventilated patients: a feasibility and clinical validity study.
The study identified several AMR genes using Nanopore sequencing, including mecA, blaTEM-4, blaTEM-112, blaTEM-157, blaACT-5, oqxB, tetC, ermA, erm (33), tet38, ant(4′)-lb, tetK, tetQ, sul1, dfrA, acrF, parE, mfd, mphA, aadA5, vgaC, blaACT-5, blaACT-14, mefA, mel, tetX, tetM, isaC, and aadA5, which conferred resistance to various antibiotics such as methicillin, ticarcillin, ceftazidime, erythromycin, clindamycin, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and levofloxacin.
Emerging Variants of the Integrative and Conjugant Element ICEMh1 in Livestock Pathogens: Structural Insights, Potential Host Range, and Implications for Bacterial Fitness and Antimicrobial Therapy.
The study identified multiple antimicrobial resistance genes within the ICE Mh1 PM22, including aminoglycoside, sulfonamide, macrolide, and tetracycline resistance genes. These genes contribute to multidrug resistance in livestock pathogens.
A Field Study Into Hong Kong's Wet Markets: Raised Questions Into the Hygienic Maintenance of Meat Contact Surfaces and the Dissemination of Microorganisms Associated With Nosocomial Infections.
The study identified antibiotic resistance genes such as tet(M), BlaTEM, and mex(B) in isolates from wooden cutting boards in Hong Kong wet markets, highlighting the potential for cross-contamination and dissemination of clinically relevant resistant organisms.
Synergistic Antibacterial Activity of Designed Trp-Containing Antibacterial Peptides in Combination With Antibiotics Against Multidrug-Resistant Staphylococcus epidermidis.
The study identified that Trp-containing peptides synergistically enhance the antibacterial activity of antibiotics against multidrug-resistant Staphylococcus epidermidis by reducing the expression of resistance genes such as bla Z, tet(m), and msr A.
Methicillin-Resistant Staphylococcus aureus Strains in Swiss Pigs and Their Relation to Isolates from Farmers and Veterinarians.
The study identifies several AMR genes in MRSA strains from Swiss pigs, including aac(6')-aph(2"), dfrG, erm(A), erm(C), spc, str, tet(K), tet(M), and vga(E). These genes confer resistance to various antibiotics such as gentamicin, kanamycin, tobramycin, trimethoprim, erythromycin, clindamycin, lincomycin, streptogramin B, streptomycin, tetracycline, streptogramin A, pleuromutilin, and lincomycin.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Antibiotic Susceptibility, Virulence Pattern, and Typing of Staphylococcus aureus Strains Isolated From Variety of Infections in India.
The study identified various AMR genes in S. aureus isolates, including mecA, pvl, czrC, qacA/B, aac(6')/aph(2), aph(3'-III), msrA, ermA, ermC, mphC, tetK, tetL, tetM, cat::pC221, cat::pC223, cat::pC194, dfrA, dfrB, and dfrG, which confer resistance to multiple antibiotics such as oxacillin, chloramphenicol, gentamicin, erythromycin, clindamycin, tetracycline, and trimethoprim.
Equations To Predict Antimicrobial MICs in Neisseria gonorrhoeae Using Molecular Antimicrobial Resistance Determinants.
The study identifies several genes and mutations associated with antimicrobial resistance in Neisseria gonorrhoeae, including PenA, mtrR, 23S rRNA, rpsJ, PorB, PonA, GyrA, ParC, and bla. These genetic elements contribute to resistance against various antibiotics such as ceftriaxone, cefixime, azithromycin, tetracycline, ciprofloxacin, and penicillin.
Antimicrobial Resistance and Virulence Gene Profiles of Methicillin-Resistant and -Susceptible Staphylococcus aureus From Food Products in Denmark.
The study identified several antimicrobial resistance genes, including blaZ, tet(K), tet(L), tet(M), and various erm genes, in Staphylococcus aureus isolates from food products in Denmark. Additionally, the tst gene was detected in CC398 and CC45 isolates, indicating the presence of toxic shock syndrome toxin.
Antimicrobial Resistance in Clostridium and Brachyspira spp. and Other Anaerobes.
The paper describes the antimicrobial resistance mechanisms in Clostridium and Brachyspira spp. and other anaerobes, focusing on the genetic basis of resistance to various antibiotics, including tetracyclines, macrolides, lincosamides, chloramphenicol, and others. It highlights the role of specific genes such as tet, erm, and cat in conferring resistance.
In Vitro Pharmacodynamic Analyses Help Guide the Treatment of Multidrug-Resistant Enterococcus faecium and Carbapenem-Resistant Enterobacter cloacae Bacteremia in a Liver Transplant Patient.
The study identifies various AMR genes and mutations in Enterococcus faecium and Enterobacter hormaechei isolates from a liver transplant patient, highlighting their roles in resistance to multiple antibiotics.
Genomic evolution of Neisseria gonorrhoeae since the preantibiotic era (1928-2013): antimicrobial use/misuse selects for resistance and drives evolution.
The study characterizes various AMR genes and mutations in Neisseria gonorrhoeae, highlighting the emergence of resistance to multiple antimicrobials over time, including penicillin, fluoroquinolones, macrolides, tetracyclines, and sulfonamides. Key findings include the identification of penB, mtrR, penA, gyrA, parC, folP, rpsJ, tetM, and blaTEM as critical AMR genes, along with mutations in penB, mtrR, gyrA, parC, penA, and ponA that contribute to resistance mechanisms.
Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum.
The study identified several AMR genes in Enterococcus spp., including erm(B), tet(M), optrA, dfrE, lsa(A), aac(6')-Ib, eat(A), ant(6)-Ia, aph(3')-IIIa, sat4, tet(L), bcrB, bcrC, dfrF, and dfrG, which confer resistance to various antibiotics such as macrolides, tetracyclines, oxazolidinones, trimethoprim, and aminoglycosides.
High prevalence of Clostridiodes diffiicle PCR ribotypes 001 and 126 in Iran.
The study identified vanA, tetM, gyrA, and gyrB genes associated with vancomycin, tetracycline, and fluoroquinolone resistance in Clostridiodes difficile strains. Mutations in gyrA and gyrB were linked to fluoroquinolone resistance.
Origin, genomic diversity and microevolution of the Clostridium difficile B1/NAP1/RT027/ST01 strain in Costa Rica, Chile, Honduras and Mexico.
Investigation of a Reduction in Tylosin on the Prevalence of Liver Abscesses and Antimicrobial Resistance in Enterococci in Feedlot Cattle.
The study identified several AMR genes in enterococci isolated from feedlot cattle, including erm(B), msr(C), tet(L), tet(M), and tet(O), which confer resistance to macrolides and tetracyclines.
Genomic Insight into the Spread of Meropenem-Resistant Streptococcus pneumoniae Spain(23F)-ST81, Taiwan.
The study identifies pbp2b, pbp2x, and pbp1a as key genes contributing to meropenem resistance in Streptococcus pneumoniae, along with ermB, tetM, and cat as resistance genes. Mutations in PBP2b, PBP2x, and PBP1a were linked to increased meropenem resistance.
Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium.
The study identified 24 different antimicrobial-resistance determinants in Gallibacterium anatis isolates from calves with unresponsive bronchopneumonia, including novel resistance genes such as aadA23, blaCARB-8, tet(Y), and qnrD1.
Whole Genome Sequencing and Characteristics of mcr-1-Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B.
The study identified the mcr-1.1 gene in five porcine E. coli isolates, which confers resistance to colistin. The gene was found on various plasmids, including IncF, IncX4, and IncHI2, highlighting the role of mobile genetic elements in the spread of colistin resistance.
The WblC/WhiB7 Transcription Factor Controls Intrinsic Resistance to Translation-Targeting Antibiotics by Altering Ribosome Composition.
The WblC/WhiB7 transcription factor controls intrinsic resistance to translation-targeting antibiotics by altering ribosome composition in Streptomyces coelicolor.
Toxin profiles and antimicrobial resistance patterns among toxigenic clinical isolates of Clostridioides (Clostridium) difficile.
The study identified ermB, tetM, and tetW genes as the primary determinants of clindamycin, tetracycline, and moxifloxacin resistance in C. difficile isolates. Mutations in GyrA (Thr82→Ile) and GyrB (Asp426→Asn) were linked to moxifloxacin resistance.
Detection of a Novel, and Likely Ancestral, Tn916-Like Element from a Human Saliva Metagenomic Library.
The study identified a novel Tn916-like element from a human saliva metagenomic library, which encodes the tetracycline resistance genes tet(M) and tet(L).
Occurrence and Characteristics of Methicillin-Resistant and -Susceptible Staphylococcus aureus Isolated from the Beef Production Chain in Korea.
The study identified the czrC gene associated with zinc chloride resistance and the tetM gene responsible for tetracycline resistance in Staphylococcus aureus isolates from the beef production chain in Korea.
Characterization of Staphylococci and Streptococci Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified multiple AMR genes in Staphylococcus and Streptococcus isolates from bovine milk, including blaZ, mecA, erm(C), aac(aph)D, tetK, tetL, tetM, lnuA, erm(A), erm(B), aphA-3, aad-6, and optrA, indicating widespread resistance to beta-lactams, macrolides, aminoglycosides, tetracyclines, and linezolid.
Profiles of Staphyloccocus aureus isolated from goat persistent mastitis before and after treatment with enrofloxacin.
The study identified several AMR genes in Staphylococcus aureus isolates from goat mastitis, including blaZ, ermA, ermB, mecA, tetK, tetM, norA, norC, and lmrS. These genes conferred resistance to various antibiotics such as penicillin, erythromycin, methicillin, tetracycline, and fluoroquinolones.
Prevalence and distribution of antimicrobial resistance determinants of Escherichia coli isolates obtained from meat in South Africa.
The study identified several AMR genes in E. coli isolates from meat in South Africa, including aadA, strA, aph(3)-Ia, aph(3)-IIa, aac(3)-IIa, blaTEM, blaZ, ampC, cat1, cat2, cmlA1, sul1, sul2, tetA, tetB, tetC, tetD, and tetM, which confer resistance to various antibiotics such as streptomycin, kanamycin, neomycin, gentamicin, amoxicillin, ampicillin, chloramphenicol, cotrimoxazole, and tetracycline.
Simultaneous Nasal Carriage by Methicillin-Resistant and Methicillin Susceptible Staphylococcus aureus of Lineage ST398 in a Live Pig Transporter.
The study characterizes two S. aureus ST398 strains, one methicillin-resistant (MRSA) and one methicillin-susceptible (MSSA), isolated from a pig transporter. The MRSA strain harbors the mecA gene, while the MSSA strain lacks it due to a large deletion. Both strains exhibit resistance to several antibiotics including tetracycline, lincosamides, aminoglycosides, and trimethoprim.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
The Virulence Potential of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Cultured from the Airways of Cystic Fibrosis Patients.
The study identified that LA-MRSA isolates from CF patients exhibited tetracycline resistance, primarily attributed to the presence of the tetM gene. These isolates also displayed increased hemolytic and cytotoxic activities compared to HA-MRSA and MSSA.
Rapid detection of antibiotic resistance genes in lactic acid bacteria using PMMA-based microreactor arrays.
The study presents a PMMA-based microreactor array for rapid detection of antibiotic resistance (AR) genes in lactic acid bacteria (LABs). Six AR genes, including strA, strB, vanA, vanB, tetM, and tetS, were successfully detected using LAMP and colorimetric methods.
Antibiotic Resistance Is Associated with Integrative and Conjugative Elements and Genomic Islands in Naturally Circulating Streptococcus pneumoniae Isolates from Adults in Liverpool, UK.
The study identifies tetracycline and macrolide resistance genes, including tet(M), erm(B), tet(32), mef(A), and msr(D), located on mobile genetic elements in naturally circulating Streptococcus pneumoniae isolates.
Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumoniae isolated from clinical samples in Tehran, Iran.
The study identified the presence of ermB, mefA/E, and tetM genes in invasive Streptococcus pneumoniae isolates, which contribute to resistance against erythromycin and tetracycline.
Antimicrobial Resistance, Virulence Genes, and Biofilm Formation Capacity Among Enterococcus species From Yaks in Aba Tibetan Autonomous Prefecture, China.
The study identified multiple antimicrobial resistance (AMR) genes in Enterococcus species isolated from yaks, including ermA, ermB, tetA, tetB, tetM, tetL, cat, optrA, and poxtA. These genes conferred resistance to various antibiotics such as erythromycin, tetracycline, chloramphenicol, and linezolid. Additionally, a high prevalence of multidrug-resistant (MDR) Enterococcus strains was observed.
Genomic analyses of multidrug-resistant Salmonella Indiana, Typhimurium, and Enteritidis isolates using MinION and MiSeq sequencing technologies.
The study identified various AMR genes in multidrug-resistant Salmonella isolates, including beta-lactamases (blaCTX-M-14, blaCTX-M-27, blaCTX-M-55, blaOXA-1, blaCMY-2, blaOXA, blaCMY), phenicol resistance genes (catB3, cmlA1, floR, catA1, catA2, oqxA, oqxB), aminoglycoside resistance genes (aac(6')-Ib-cr5, aac(6')-Ib-cr, oqxA2, qepA1, qnrS1), sulfonamide and trimethoprim resistance genes (sul1, sul2, sul3, dfrA12, dfrA7), and tetracycline resistance genes (tet(A), tet(B), tet(M)).
Antibiotic Resistance Patterns of Pseudomonas spp. Isolated From Raw Milk Revealed by Whole Genome Sequencing.
The study identified various AMR genes and mutations in Pseudomonas spp. isolated from raw milk, highlighting the prevalence of multidrug-resistant strains and the presence of resistance determinants such as beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps.
Clonal Spread of Tetracycline Resistance Among Mycoplasma hominis Clinical Strains, Tunisia.
The study identifies the tet(M) gene as a key determinant of tetracycline resistance in Mycoplasma hominis clinical strains in Tunisia, highlighting clonal spread of resistance.
Antibiotic Resistance-Susceptibility Profiles of Enterococcus faecalis and Streptococcus spp. From the Human Vagina, and Genome Analysis of the Genetic Basis of Intrinsic and Acquired Resistances.
The study identified tetracycline resistance genes tet(M) and tet(L) in Enterococcus faecalis and Streptococcus anginosus, and the lsaA gene associated with resistance to clindamycin and quinupristin-dalfopristin in E. faecalis. These genes were validated through PCR, genome sequencing, and functional analysis.
Genetic analysis of methicillin-susceptible Staphylococcus aureus clinical isolates: High prevalence of multidrug-resistant ST239 with strong biofilm-production ability.
The study identified high prevalence of multidrug-resistant ST239 isolates with strong biofilm-producing ability. Key AMR genes included mupA, fusC, erm(A), erm(C), ant(4')-Ia, aac(6')-Ie/aph(2''), aph(3')-IIIa, tetM, and tetK.
Occurrence, Virulence and Antimicrobial Resistance-Associated Markers in Campylobacter Species Isolated from Retail Fresh Milk and Water Samples in Two District Municipalities in the Eastern Cape Province, South Africa.
The study identified several antimicrobial resistance genes in Campylobacter species isolated from retail fresh milk and water samples, including catII, tetA, tetB, tetM, ermB, gyrA, ampC, and aac(3)-IIa-(aacC2). These genes were associated with resistance to chloramphenicol, tetracycline, erythromycin, gentamicin, and ampicillin.
Whole genome sequencing of macrolide resistant Streptococcus pneumoniae serotype 19A sequence type 416.
The study identified the presence of erm(B) and tet(M) genes in macrolide-resistant Streptococcus pneumoniae serotype 19A sequence type 416 isolates, contributing to resistance against erythromycin, clindamycin, and tetracycline.
In vitro activity of eravacycline against common ribotypes of Clostridioides difficile.
The study found that eravacycline showed potent in vitro activity against various ribotypes of Clostridioides difficile, and the presence of tetM or tetW resistance genes did not affect the MIC of eravacycline.
MYCO WELL D-ONE detection of Ureaplasma spp. and Mycoplasma hominis in sexual health patients in Wales.
The study identifies the Ser83Leu mutation in the parC gene as a mechanism of levofloxacin resistance in Ureaplasma spp. and the Tn916 tet(M) transposon as a mechanism of tetracycline resistance in Ureaplasma spp. and Mycoplasma hominis.
Comparison of antimicrobial resistant genes in chicken gut microbiome grown on organic and conventional diet.
The study identified various antimicrobial resistance genes in the gut microbiome of chickens raised on organic and conventional diets, including beta-lactamases, multidrug efflux systems, aminoglycoside modifying enzymes, and tetracycline resistance genes. These genes were found to be more prevalent in conventional diet samples under higher antibiotic concentrations.
Molecular subtyping and antimicrobial susceptibility of Streptococcus dysgalactiae subspecies equisimilis isolates from clinically diseased pigs.
The study identified macrolide resistance genes erm(B) and mef(A/E), tetracycline resistance genes tet(M) and tet(O), and two mutations in parC associated with fluoroquinolone resistance in SDSE isolates from pigs.
Comparative genome analysis of Erysipelothrix rhusiopathiae isolated from domestic pigs and wild boars suggests host adaptation and selective pressure from the use of antibiotics.
The study identified tetracycline resistance gene tet(M), and combinations of lsa(E) and lnu(B) conferring resistance to lincosamides, pleuromutilins, and streptogramin A in Erysipelothrix rhusiopathiae isolates from pigs, but not in wild boar isolates.
Prevalence of diversified antibiotic resistant bacteria within sanitation related facilities of human populated workplaces in Abbottabad.
The study identified tetracycline resistance genes (tetA and tetM) in Pseudomonas putida strains isolated from sanitation facilities in Abbottabad, indicating plasmid-mediated resistance.
Drug Resistance Determinants in Clinical Isolates of Enterococcus faecalis in Bangladesh: Identification of Oxazolidinone Resistance Gene optrA in ST59 and ST902 Lineages.
The study identified the oxazolidinone resistance gene optrA in Enterococcus faecalis isolates from Bangladesh, along with other resistance genes such as erm(B), aac(6')-Ie-aph(2'')-Ia, tet(M), and tet(L). Mutations in gyrA and parC were associated with levofloxacin resistance.
Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study.
The study identified 55 different antimicrobial resistance determinants in diarrheal pathogens, highlighting the presence of genes conferring resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, macrolides, tetracyclines, phenicols, sulfonamides, and others. Notably, carbapenemase genes like bla OXA-48 and bla NDM were detected in certain isolates, indicating emerging resistance concerns.
Staphylococci in poultry intestines: a comparison between farmed and household chickens.
The study identified several AMR genes in staphylococci from poultry intestines, including ermC, mecA, tetK, tetM, and aacA-aphD, which confer resistance to erythromycin, clindamycin, tetracycline, and gentamicin. Multidrug resistance was prevalent among the isolates.
High precision Neisseria gonorrhoeae variant and antimicrobial resistance calling from metagenomic Nanopore sequencing.
The study identifies plasmid-mediated resistance genes blaTEM-1 and tetM in Neisseria gonorrhoeae using Nanopore sequencing, demonstrating their presence in clinical samples.
Antimicrobial Resistance Gene Detection and Plasmid Typing Among Multidrug Resistant Enterococci Isolated from Freshwater Environment.
The study identified twelve antimicrobial resistance genes in multidrug-resistant Enterococcus isolates from freshwater, including genes conferring resistance to tetracycline, erythromycin, tylosin, kanamycin, streptomycin, and ciprofloxacin. These genes were detected through PCR and sequencing, highlighting the diversity of resistance mechanisms in environmental Enterococcus.
Genomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure.
The study identified various AMR genes and mutations associated with daptomycin resistance in MRSA strains, including genes such as aac(6')-Ib, blaZ, mecA, ermC, fexB, tetM, tet38, dfrC, fosD, and vgaA, as well as mutations in mprF, rpoB, grlA, grlB, and gyrA.
Farming Practices Influence Antibiotic Resistance and Biogenic Amine Capacity of Staphylococci from Bulk Tank Ewe's Milk.
The study identified tetracycline resistance gene tetM, erythromycin resistance genes ermB and ermC, and ciprofloxacin resistance gene grlA in staphylococci from bulk tank ewe's milk. These genes were experimentally validated through PCR and phenotypic assays.
Plasmid mediated penicillin and tetracycline resistance among Neisseria gonorrhoeae isolates from Kenya.
The study identifies plasmid-mediated resistance genes blaTEM-1, blaTEM-239, and tetM in Neisseria gonorrhoeae isolates from Kenya, along with chromosomal mutations in mtrR, penB, and s10 that contribute to resistance.
Pyrolyzed biowastes deactivated potentially toxic metals and eliminated antibiotic resistant genes for healthy vegetable production.
The study found that pyrolysis of biowastes effectively reduced the abundance of antibiotic resistance genes (ARGs) such as tetracycline resistance genes (tetC, tetG, tetM, tetO, tetW), sulfonamide resistance genes (sul1, sul2), and class 1 integron-integrase gene (intI1) in swine manure and sewage sludge.
Genome Characterization of mcr-1-Positive Escherichia coli Isolated From Pigs With Postweaning Diarrhea in China.
The study identifies multiple antimicrobial resistance genes, including mcr-1.1 and mcr-3.1, in multidrug-resistant E. coli isolates from pigs with postweaning diarrhea in China.
Exploration of the Neisseria Resistome Reveals Resistance Mechanisms in Commensals That May Be Acquired by N. gonorrhoeae through Horizontal Gene Transfer.
The study identifies resistance mechanisms in commensal Neisseria species, including the presence of blaTEM-1, tetM, and gyrA mutations, which can be horizontally transferred to N. gonorrhoeae.
Characterization of Pneumococcal Colonization Dynamics and Antimicrobial Resistance Using Shotgun Metagenomic Sequencing in Intensively Sampled South African Infants.
The study identified AMR genes such as msrD, mefA, ermB, and tetM, along with mutations in pbp1a (S351A), pbp2x (H394L), folA (I100L), and folP (6-bp insertion) associated with resistance to erythromycin, penicillin, and cotrimoxazole in Streptococcus pneumoniae.
Antibiotic resistance and typing of the methicillin-resistant Staphylococcus aureus clones in Kuwait hospitals, 2016-2017.
The study identified various AMR genes in MRSA isolates from Kuwait hospitals, including mupA, aacA-aphD, erm(A), erm(C), tet(K), tet(M), fusC, fusB, and faR1, which conferred resistance to mupirocin, gentamicin, erythromycin, tetracycline, and fusidic acid.
Antimicrobial Resistance of Coagulase-Positive Staphylococcus Isolates Recovered in a Veterinary University Hospital.
The study identified various antimicrobial resistance genes in methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates, including blaZ, erm(B), erm(C), aph(3'), ant(6), aad(6), SAT-4, cat(pc221), dfr(G), tet(K), and tet(M). These genes were associated with resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, trimethoprim, and tetracycline.
Features of Streptococcus agalactiae strains recovered from pregnant women and newborns attending different hospitals in Ethiopia.
The study identified tetracycline resistance genes tetM, tetL, and tetO, macrolide/lincosamide resistance genes ermTR, ermB, and lnu, and aminoglycoside resistance gene aac(6')-Ib in Streptococcus agalactiae isolates. Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
Evidence for the Dissemination to Humans of Methicillin-Resistant Staphylococcus aureus ST398 through the Pork Production Chain: A Study in a Portuguese Slaughterhouse.
The study identified multiple antimicrobial resistance genes in MRSA ST398 isolates from a Portuguese slaughterhouse, highlighting the dissemination of these resistant strains through the pork production chain and their potential to colonize humans.
Occurrence, identification, and antibiogram signatures of selected Enterobacteriaceae from Tsomo and Tyhume rivers in the Eastern Cape Province, Republic of South Africa.
The study identified various beta-lactamase genes (bla TEM, bla CTX-M, bla SHV, bla OXA-1-like, bla PER, bla VIM, bla IMP, bla KPC, bla GES, bla OXA-48-like), plasmid-mediated AmpC beta-lactamase genes (bla EBC, bla ACC, bla FOX, bla CIT), tetracycline resistance genes (tetA, tetB, tetD, tetM), chloramphenicol resistance gene (catII), and sulfonamide resistance gene (sulII) in Enterobacteriaceae isolates from Tsomo and Tyhume rivers.
Use of Oral Tetracyclines in the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia: A Literature Review on the Often-Overlooked Antibiotic Class.
The review highlights the mechanisms of resistance to tetracyclines, including efflux pumps (tet(K), tet(L), tet(B)), ribosomal protection proteins (tet(M)), and enzymatic deactivation (tet(X)). These genes confer resistance to tetracycline, doxycycline, minocycline, and omadacycline in various bacterial pathogens.
Prevalence of antimicrobial-resistant staphylococci in nares and affected sites of pet dogs with superficial pyoderma.
The study identified several antimicrobial resistance genes including aacA-aphD, tetM, ermB, and lnuA in Staphylococcus pseudintermedius, Staphylococcus schleiferi, and Staphylococcus aureus isolated from pet dogs with superficial pyoderma. These genes conferred resistance to gentamicin, tetracycline, erythromycin, and lincomycin.
Occurrence of typical antibiotics, representative antibiotic-resistant bacteria, and genes in fresh and stored source-separated human urine.
The study identified tetracycline-resistant Escherichia coli carrying the tetM gene in fresh source-separated human urine, highlighting the presence of antibiotic resistance genes in urine samples.
Multidrug Resistance in Enterococci Isolated From Wild Pampas Foxes (Lycalopex gymnocercus) and Geoffroy's Cats (Leopardus geoffroyi) in the Brazilian Pampa Biome.
The study identified multidrug-resistant Enterococcus strains in wild Pampas foxes and Geoffroy's cats, with resistance genes ermB, msrC, tetL, and tetM detected in erythromycin and tetracycline-resistant isolates.
The nucleotide sequence of the tetracycline resistance determinant tetM from Ureaplasma urealyticum.
The nucleotide sequence of the tetracycline resistance determinant tetM from Ureaplasma urealyticum.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Tetracycline Resistance Mediated by tet(M) Has Variable Integrative Conjugative Element Composition in Mycoplasma hominis Strains Isolated in the United Kingdom from 2005 to 2015.
The study identifies the tet(M) gene as the primary mediator of tetracycline resistance in Mycoplasma hominis strains, with variable integrative conjugative element (ICE) compositions.
Antimicrobial resistance and virulence factors in livestock-associated MRSA from German dairy farms
The study identified various antimicrobial resistance genes in livestock-associated MRSA from German dairy farms, including mecA, fexA, tet(K), tet(M), vga(A), vga(E), dfrG, dfrK, aac(6')Ie-aph(2")Ia, str, spc, lsa(E), and erm(A). These genes conferred resistance to beta-lactams, chloramphenicol, tetracyclines, pleuromutilins, trimethoprim, aminoglycosides, streptomycin, spectinomycin, macrolides, lincosamides, and streptogramin B.
Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids in Salmonella Serovars from Poultry in Nigeria.
The study identified various antimicrobial resistance genes in Salmonella isolates from Nigerian poultry, including aac(6')-Ia, aac(6')-Ib, aadA7, aph(3")-Ia, aph(3")-Ib, aph(6')-Id, aph(6')-Ic, aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-IIa, aac(3)-Id, sul1, sul2, sul3, tet(A), tet(M), qnrS1, qnrB19, blaTEM, dfrA14, dfrA15, dfrA17, catA1, cmlA1, and floR. Mutations in gyrA (Ser83Phe, Asp87Tyr) and parC (Thr57Ser, Ser80Ile) were also associated with resistance to nalidixic acid and ciprofloxacin.
A Preliminary Study: Antibiotic Resistance of Escherichia coli and Staphylococcus aureus from the Meat and Feces of Various South African Wildlife Species.
The study identified antibiotic resistance genes in Escherichia coli and Staphylococcus aureus from wildlife meat and feces, including blaCMY, aadA, sul1, sul2, tetA, tetB, tetK, tetL, tetM, vanA, vanB, and blaZ, which conferred resistance to ampicillin, streptomycin, sulfonamides, tetracycline, vancomycin, and penicillin.
Occurrence of Antibiotic Resistance Genes in Hermetia illucens Larvae Fed Coffee Silverskin Enriched with Schizochytrium limacinum or Isochrysis galbana Microalgae.
The study identified several tetracycline resistance genes (tet(M), tet(S), tet(K)), erythromycin resistance genes (erm(B), erm(C)), a methicillin resistance gene (mecA), and an aminoglycoside resistance gene (aac(6')-Ib) in Hermetia illucens larvae and frass. The presence of these genes suggests potential safety concerns regarding the reuse of frass in agriculture.
Epidemiological analysis of pneumococcal strains isolated at Yangon Children's Hospital in Myanmar via whole-genome sequencing-based methods.
The study identified multiple AMR genes and mutations in pneumococcal strains from Myanmar, including genes conferring resistance to azithromycin, tetracycline, chloramphenicol, and quinolones, as well as mutations in penicillin-binding proteins and DNA gyrase. These findings highlight the spread of AMR in pneumococcal strains in Myanmar.
Predominance of III/ST19 and Ib/ST10 Lineages With High Multidrug Resistance in Fluoroquinolone-Resistant Group B Streptococci Isolates in Which a New Integrative and Conjugative Element Was Identified.
The study identifies mutations in gyrA and parC genes contributing to fluoroquinolone resistance in Group B Streptococcus (GBS) isolates, along with the presence of resistance genes tetM, ermB, and lnuB. A new integrative and conjugative element (ICE) carrying tetM and gyrA was also identified.
SWINE VIRULENCE ASSESSMENT
This study analyzed the virulence and genomic characteristics of nine United States Streptococcus suis isolates, identifying genomic attributes associated with swine-virulent phenotypes. However, no specific AMR genes or mutations were experimentally validated in this paper.
Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins.
The study identifies several ribosomal protection protein (RPP) genes, including tet(M), tet(O), tet(W), tet(Q), tetB(P), and otr(A), that can confer high-level tetracycline resistance in E. coli. However, expression of these genes often comes with fitness costs, and certain mutations in tRNA genes (argW and proL) or the hns gene can mitigate these costs.
Clonal Diversity and Antimicrobial Resistance of Methicillin-Resistant Staphylococcus pseudintermedius Isolated from Canine Pyoderma.
All 31 MRSP isolates were multidrug-resistant, showing resistance to penicillin, macrolides, lincosamides, aminoglycosides, tetracycline, and trimethoprim-sulfamethoxazole. Key resistance genes identified include blaZ, ermB, msr(A/B), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, ant(4')-Ia, tetM, tetK, and dfrG.
Examination of Staphylococcus aureus Prophages Circulating in Egypt.
Genomic Insights Into the Pathogenicity of a Novel Biofilm-Forming Enterococcus sp. Bacteria (Enterococcus lacertideformus) Identified in Reptiles.
The study identified several antimicrobial resistance and virulence genes in Enterococcus lacertideformus, including DfrE, EfrB, ClpP, Fss3, and various metal resistance genes such as mgtA, copB, and ziaA. These genes suggest resistance to trimethoprim, macrolides, rifamycins, fluoroquinolones, and heavy metals.
The Emergence of Invasive Streptococcus pneumoniae Serotype 24F in Lebanon: Complete Genome Sequencing Reveals High Virulence and Antimicrobial Resistance Characteristics.
The study identified the presence of ermB and tet(M) genes in Streptococcus pneumoniae serotype 24F isolates, which confer resistance to erythromycin, clindamycin, and tetracycline.
A platform for detecting cross-resistance in antibacterial drug discovery.
The study presents a cross-resistance platform (CRP) consisting of 28 Staphylococcus aureus strains with defined resistance genotypes, designed to detect cross-resistance between established and novel antibacterial agents. The CRP includes various AMR genes and mutations that confer resistance to multiple antibiotic classes.
Prevalence, diversity and transferability of the Tn916-Tn1545 family ICE in oral streptococci.
The study identified Tn916-Tn1545 family elements in oral streptococci, including novel variants Tn6815 and Tn6816, which carry the tetracycline resistance gene tet(M).
New Insights into the Virulence Traits and Antibiotic Resistance of Enterococci Isolated from Diverse Probiotic Products.
The study identifies multiple antibiotic resistance genes, including msrC, lsaA, aac(6')-Ii, vanC, and tetM, in enterococci isolated from probiotic products, highlighting the potential risk of antimicrobial resistance and virulence factors in these isolates.
Emergence of High Level Carbapenem and Extensively Drug Resistant Escherichia coli ST746 Producing NDM-5 in Influent of Wastewater Treatment Plant, Seoul, South Korea.
The study reports the emergence of a high-level carbapenem-resistant and extensively drug-resistant (XDR) Escherichia coli strain N7 producing NDM-5, highlighting the presence of multiple resistance genes on plasmids and chromosomes.
Evaluation of commercial probiotics for antimicrobial resistance genes.
The study found that 94% of the evaluated commercial probiotics contained at least one transferable antimicrobial resistance (AMR) gene, with 82% containing two or more. The most commonly detected AMR genes were tetK (68%) and sul2 (60%).
From the Farms to the Dining Table: The Distribution and Molecular Characteristics of Antibiotic-Resistant Enterococcus spp. in Intensive Pig Farming in South Africa.
The study identified tetracycline, erythromycin, streptomycin, and gentamicin resistance genes in Enterococcus spp. isolated from intensive pig farming in South Africa, highlighting the presence of multidrug-resistant strains and the potential for transmission to humans.
A Real-Time Thermal Sensor System for Quantifying the Inhibitory Effect of Antimicrobial Peptides on Bacterial Adhesion and Biofilm Formation.
The study identified several AMR genes in E. coli and S. aureus isolates, including beta-lactamases (blaOXA-1, blaTEM-1A), chloramphenicol acetyltransferase (catA1), trimethoprim resistance gene (dfrA1), fluoroquinolone resistance gene (floR), sulfonamide resistance genes (sul1, sul2), methicillin resistance gene (mecA), beta-lactamase (blaZ-like), and tetracycline efflux pumps (tet(K), tet(M)).
Characterization of methicillin-resistant Staphylococcus pseudintermedius isolates from Australian animals: discovery of novel sequence types
The study identified several AMR genes in MRSP isolates, including blaZ, mecA, cat-pC221, ermB, ermC, tetM, dfrG, aac6-aph2, ant6-Ia, aph3-III, and aadD, which confer resistance to various antibiotics such as oxacillin, penicillin, chloramphenicol, erythromycin, clindamycin, tetracycline, trimethoprim, and gentamicin.
Analysis of Genome Sequences of Coagulase-Negative Staphylococci Isolates from South Africa and Nigeria Highlighted Environmentally Driven Heterogeneity.
The study identified several AMR genes in coagulase-negative staphylococci isolates from South Africa and Nigeria, highlighting environmentally driven heterogeneity. Notably, the tetM gene was found in South African isolates but not in Nigerian ones, while cadmium resistance genes were present in Nigerian isolates. Other genes like blaZ, FosB, mecA, FusF, dfrG, ErmA, ErmB, Erm(43), and mphC were also characterized.
Antibiotic resistance profiles and population structure of disease-associated Staphylococcus aureus infecting patients in Fort Portal Regional Referral Hospital, Western Uganda.
The study identified various AMR genes in S. aureus isolates from Fort Portal Regional Referral Hospital, including blaZ, dfrA, dfrG, ermA, ermC, msrA, tetK, and tetM, contributing to resistance against multiple antibiotics. Additionally, mecA was detected, indicating methicillin resistance.
Emergence of Invasive Serotype Ib Sequence Type 10 Group B Streptococcus Disease in Chinese Infants Is Driven by a Tetracycline-Sensitive Clone.
The study identifies the emergence of invasive serotype Ib sequence type 10 Group B Streptococcus (GBS) disease in Chinese infants, highlighting the presence of multiple resistance mechanisms including ermB, mefA, lnuB, tetM, and tetO genes, along with fluoroquinolone resistance mediated by mutations in gyrA and parC.
Ribosome Protection Proteins-'New' Players in the Global Arms Race with Antibiotic-Resistant Pathogens.
The paper discusses ribosome protection proteins (RPPs) as significant contributors to antibiotic resistance, particularly against tetracyclines, fusidic acid, and various other antibiotics targeting the ribosome. Key RPPs include TetM, TetO, FusB, VgaA, LsaA, MsrE, MsrA, optrA, and poxtA, which confer resistance through mechanisms involving direct interaction with the ribosome and displacement of antibiotics.
Virulence Factors in Staphylococcus Associated with Small Ruminant Mastitis: Biofilm Production and Antimicrobial Resistance Genes.
The study identified the blaZ gene in several Staphylococcus species, including S. chromogenes, S. aureus, S. warneri, S. auricularis, S. caprae, and S. simulans, which conferred resistance to penicillin. Additionally, the tetK and tetM genes were found in S. aureus isolates, providing resistance to tetracycline.
Genomic surveillance of Neisseria gonorrhoeae in the Philippines, 2013-2014.
The study identified several AMR genes and mutations in Neisseria gonorrhoeae isolates from the Philippines, including bla TEM for penicillin resistance, tetM for tetracycline resistance, and various mutations in gyrA, parC, mtrR, rpsJ, penA, ponA, and porB that contribute to resistance against penicillin, ciprofloxacin, and tetracycline.
Effects of Ursolic Acid on Intestinal Health and Gut Bacteria Antibiotic Resistance in Mice.
Ursolic acid reduced the expression of tetracycline resistance genes in the gut microbiota of antibiotic-exposed mice.
Whole-Genome Analysis of Streptococcus pneumoniae Serotype 4 Causing Outbreak of Invasive Pneumococcal Disease, Alberta, Canada.
The study identified antimicrobial resistance determinants in 7 out of 190 S. pneumoniae serotype 4 isolates, including a single ParC D83 aa substitution, ermB and tetM determinants, folA I100L, and folP amino acid insertion.
Antimicrobial Resistance Profiles and Genes of Staphylococci Isolated from Mastitic Cow's Milk in Kenya.
The study identified several antimicrobial resistance genes in staphylococci isolated from mastitic cow's milk in Kenya, including blaZ, strB, msrA, ermB, tetM, and tetK, which confer resistance to beta-lactams, streptomycin, erythromycin, and tetracycline.
Antimicrobial Resistance Profiles of Coagulase-Negative Staphylococci in Community-Based Healthy Individuals in Germany.
The study identified several AMR genes in commensal CoNS from healthy individuals in Germany, including mecA, tetK/L, tetM, ermA, ermC, ermB, fusB, fusC, aac(6')/aph(2"), cat194, fexB, and spc. These genes were associated with resistance to methicillin, tetracycline, erythromycin, fusidic acid, gentamicin, chloramphenicol, florfenicol, and spectinomycin.
Antimicrobial Susceptibility of Lactic Acid Bacteria Strains of Potential Use as Feed Additives - The Basic Safety and Usefulness Criterion.
The study identified several AMR genes in LAB strains, including aph(3")-IIIa, erm(B), lnu(A), msr(C), tet(K), and tet(M), which confer resistance to aminoglycosides, macrolides, lincomycins, and tetracyclines. These findings highlight the potential of LAB as reservoirs of AMR genes.
Antimicrobial Resistance Mechanisms, Multilocus Sequence Typing, and NG-STAR Sequence Types of Diverse Neisseria gonorrhoeae Isolates in KwaZulu-Natal, South Africa.
The study identified multiple AMR genes and mutations in Neisseria gonorrhoeae isolates from KwaZulu-Natal, South Africa, including blaTEM, penA_ins346D, ponA_L421P, mtrR_G45D, porB1b_G120K, porB1b_A121N, mtrR_disrupted, tetM, rpsJ_V57M, gyrA_S91F, gyrA_D95G, gyrA_D95A, parC_D86N, S87N, and S87I, which confer resistance to penicillin, tetracycline, and ciprofloxacin.
Role of CRISPR-Cas system on antibiotic resistance patterns of Enterococcus faecalis.
The study identified several AMR genes, including tetM, ermB, aac6'-aph(2"), aadE, ant(6), and vanA, which are associated with resistance to tetracycline, erythromycin, gentamicin, and vancomycin in Enterococcus faecalis isolates.
Analysis of Virulence and Antimicrobial Resistance Gene Carriage in Staphylococcus aureus Infections in Equids Using Whole-Genome Sequencing.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from equids, including blaZ, mupA, lnuA, tetK, tetL, tetM, norA, dfrC, dfrG, dfrK, ermA, ermC, msrA, mphC, qacA/B, qacC, and fosB. An isolate (17-021) was found to carry the lnuA gene and mupA plasmid, conferring resistance to clindamycin and mupirocin. A mutation in the prs gene was associated with phenotypic susceptibility to β-lactam drugs in a mecA-positive isolate.
Genomic Epidemiology of Multidrug-Resistant Nontyphoidal Salmonella in Young Children Hospitalized for Gastroenteritis.
Whole Genome Analysis of Three Multi-Drug Resistant Listeria innocua and Genomic Insights Into Their Relatedness With Resistant Listeria monocytogenes.
The study identified multiple AMR genes in three multi-drug resistant L. innocua isolates, including tet(M), optrA, fexA, dfrG, lnu(B), lsa(E), ant(6)-Ia, erm(B), aph(3')-IIIa, catA8, lnu(A), msr(D), and mef(A). These genes confer resistance to various antibiotics such as tetracycline, oxazolidinones, fluoroquinolones, trimethoprim, lincomycin, macrolides, aminoglycosides, and chloramphenicol.
Antibiotic-resistant bacteria, antibiotic resistance genes, and antibiotic residues in wastewater from a poultry slaughterhouse after conventional and advanced treatments.
The study identified several antibiotic resistance genes (ARGs) in wastewater from a poultry slaughterhouse, including bla TEM, bla CTX-M-1, bla SHV-12, mcr-1, ermB, sul1, tetM, bla OXA-48, bla CMY-2, and vanA. These genes were found to confer resistance to various antibiotics such as beta-lactams, macrolides, sulfonamides, tetracyclines, carbapenems, and glycopeptides.
Resistance and virulence distribution in enterococci isolated from broilers reared in two farming systems.
The study identified tetracycline, erythromycin, gentamicin, and penicillin resistance genes in enterococci from broilers, with no vancomycin-resistant isolates found.
Genomic Analysis of Antibiotic-Resistant Staphylococcus epidermidis Isolates From Clinical Sources in the Kwazulu-Natal Province, South Africa.
The study identified multiple antibiotic resistance genes in methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, tet(K), erm(A), erm(B), erm(C), dfrG, aac(6')-aph(2''), and cat(pC221), which confer resistance to beta-lactams, tetracyclines, macrolides, lincosamides, streptogramin B, trimethoprim, aminoglycosides, and chloramphenicol.
Prevalence and Characteristics of Staphylococcus aureus Isolated From Retail Raw Milk in Northern Xinjiang, China.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from retail raw milk in northern Xinjiang, China, including blaZ, mecA, ermA, ermB, ermC, aacA-aphD, tetK, tetM, vanA, rpoB, linA, optrA, and cfr, which confer resistance to penicillin, methicillin, oxacillin, erythromycin, gentamicin, tetracycline, vancomycin, rifampin, clindamycin, linezolid, chloramphenicol, and florfenicol.
Genetic Features of Plasmid- and Chromosome-Mediated mcr-1 in Escherichia coli Isolates From Animal Organs With Lesions.
The study characterizes the mcr-1 gene and various other resistance genes in Escherichia coli isolates from animal organs with lesions, highlighting their multidrug resistance profiles and the genetic features of plasmids carrying these genes.
Genomic Characterization of Multidrug-Resistant Salmonella Serovars Derby and Rissen From the Pig Value Chain in Vietnam.
The study identified multiple antimicrobial resistance genes in Salmonella serovars Derby and Rissen from Vietnam, highlighting the presence of multidrug-resistant strains along the pig value chain.
Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection.
Nine Clostridioides difficile strains isolated from Korean patients were analyzed, revealing diverse antibiotic resistance genes including those conferring resistance to erythromycin, clindamycin, glycopeptides, fluoroquinolones, aminoglycosides, and tetracyclines.
Misidentification of meticillin-resistant Staphylococcus aureus by the Cepheid Xpert MRSA NxG assay, the Netherlands, February to March 2021.
The study reports two false-negative results in detecting meticillin-resistant Staphylococcus aureus (MRSA) using the Cepheid Xpert MRSA NxG assay. The isolates were resistant to multiple antibiotics, including beta-lactams, aminoglycosides, and tetracyclines, and carried resistance genes such as blaZ, mecA, erm(T), aac(6')-aph(2"), tet(L), and tet(M).
Epidemiology of Staphylococcus pseudintermedius in cats in Poland.
The study characterized the antibiotic resistance profiles of Staphylococcus pseudintermedius isolates from cats in Poland, identifying several resistance genes including blaZ, mecA, aac(6')Ie-aph(2")Ia, ermB, tet(L), and tet(M).
Population genetic structure, serotype distribution and antibiotic resistance of Streptococcus pneumoniae causing invasive disease in children in Argentina.
The study identified several AMR genes in Streptococcus pneumoniae isolates from Argentina, including ermB, mefA, tet(M), cat, folA, and folP, which confer resistance to erythromycin, tetracycline, chloramphenicol, and cotrimoxazole. These genes were validated through molecular characterization and WGS.
Population Genomics Reveals Distinct Temporal Association with the Emergence of ST1 Serotype V Group B Streptococcus and Macrolide Resistance in North America.
The study identifies macrolide resistance genes erm(A), erm(B), and lsa(C) in ST1 serotype V Group B Streptococcus, highlighting their association with increased macrolide resistance in adult invasive disease.
Genomic and pathogenic investigations of Streptococcus suis serotype 7 population derived from a human patient and pigs.
The study identified several AMR genes in Streptococcus suis serotype 7 strains, including tetracycline resistance genes (tet(O), tet(M), tet(W)), macrolide/lincosamide/streptogramin resistance gene (erm(B)), aminoglycoside resistance genes (ant(6)-Ia, aph(3')-IIIa, aac(6')-Ie-aph(2'')-Ia), trimethoprim resistance gene (dfrF), and chloramphenicol resistance gene (cat-TC).
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms.
The study identified several ESBL genes, colistin resistance genes, and other AMR genes in ESBL-producing E. coli from pigs and pig farm workers in Vietnam. Key findings include the prevalence of bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27, along with mcr-1 and mcr-3 for colistin resistance, and various other resistance genes for aminoglycosides, quinolones, tetracyclines, chloramphenicol, macrolides, and sulfonamides.
Integrating the Human and Animal Sides of Mycoplasmas Resistance to Antimicrobials.
The paper discusses various mechanisms of antimicrobial resistance in mycoplasmas, including chromosomal mutations in 23S rRNA, gyrA, parC, and 16S rRNA, as well as the tet(M) gene. These mutations and genes are associated with resistance to macrolides, fluoroquinolones, tetracyclines, and other antibiotics.
Incidence of Tetracycline and Erythromycin Resistance in Meat-Associated Bacteria: Impact of Different Livestock Management Strategies.
The study identified tet K, tet M, erm B, and erm C as the primary genes responsible for tetracycline and erythromycin resistance in meat-associated bacteria, highlighting the impact of livestock management strategies on the spread of antibiotic resistance.
Evaluation of Tetracycline Resistance and Determination of the Tentative Microbiological Cutoff Values in Lactic Acid Bacterial Species.
The study identified five tetracycline resistance genes (tet(M), tet(W/N/W), tet(L), tet(S), and tet(45)) in lactic acid bacteria (LAB) and determined species-specific microbiological cutoff values for tetracycline resistance.
Molecular Epidemiology, Antimicrobial Surveillance, and PK/PD Analysis to Guide the Treatment of Neisseria gonorrhoeae Infections.
The study identified several AMR genes and mutations in N. gonorrhoeae isolates, including blaTEM-1B, tet(M), rpsJ, and various mutations in mtrR, gyrA, parC, porB, and penA. These findings highlight the resistance mechanisms to penicillin, tetracycline, ciprofloxacin, and azithromycin.
Molecular Characterization of Staphylococcus aureus Isolated from Human and Food Samples in Northern Algeria.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from human and food samples in northern Algeria, including blaZ, ermB, ermC, aphA3, sat, tetK, and tetM.
Prediction of Antimicrobial Resistance in Clinical Enterococcus faecium Isolates Using a Rules-Based Analysis of Whole-Genome Sequences.
The study identified several AMR genes and mutations in Enterococcus faecium isolates, including pbp5, vanA, vanB, aac(6')-Ie-aph(2")-Ia, gyrA, parC, tet(L), tet(M), tet(S), and 23S rRNA. These genes and mutations were validated experimentally and showed high accuracy in predicting antimicrobial resistance.
Antibiotic resistance genes in layer farms and their correlation with environmental samples.
The study identified and quantified 13 antibiotic resistance genes (ARGs) in layer manure, layer manure fertilizer, and soil samples from Guangdong Province, highlighting the high prevalence and abundance of these genes, particularly ermB, tetA, and sul2, and their potential environmental impact.
The antimicrobial resistance landscape of Neisseria gonorrhoeae in New Zealand from November 2018 to March 2019 and the role of sexual orientation in transmission.
The study identified several AMR genes and mutations in Neisseria gonorrhoeae isolates from New Zealand, including blaTEM-1, blaTEM-135, tetM, 23S C2611T, rpsJ V57M, mtrR A39T, mtrR G45D, penA mutations, penB mutations, ponA L421P, gyrA mutations, parC mutations, and norM promoter mutations, which contribute to resistance against various antibiotics such as penicillin, tetracycline, azithromycin, ciprofloxacin, ceftriaxone, and cefixime.
Antimicrobial resistance in the globalized food chain: a One Health perspective applied to the poultry industry.
The paper discusses the prevalence of antimicrobial resistance in poultry-related pathogens such as Salmonella, Campylobacter, Enterococcus, E. coli, and S. aureus, highlighting resistance to various antibiotics including ampicillin, tetracycline, and ciprofloxacin.
Antibiotic sensitivity patterns in Staphylococcus spp. isolated from goat milk in association with molecular detection of antibiotic resistance genes.
The study identified several antibiotic resistance genes in Staphylococcus spp. isolated from goat milk, including blaZ, mecA, tetK, and tetM, which confer resistance to penicillin, methicillin, and tetracycline.
Antimicrobial resistance, virulence genes and biofilm formation in Enterococcus species isolated from milk of sheep and goat with subclinical mastitis.
The study identified several antimicrobial resistance genes, including blaZ, vanA, ermB, tetM, and optrA, in Enterococcus species isolated from subclinical mastitic milk. High rates of multidrug resistance were observed, particularly against oxacillin, vancomycin, and linezolid.
Antimicrobial Resistance in Enterococcus Spp. Isolated from a Beef Processing Plant and Retail Ground Beef.
The study identified several AMR genes, including tet(M), erm(B), msrC, aac(6')-Ii, and optrA, in Enterococcus faecalis and Enterococcus faecium isolates from a beef processing plant and retail ground beef.
A species-wide genetic atlas of antimicrobial resistance in Clostridioides difficile.
This study identifies multiple AMR genes and mutations in Clostridioides difficile, including ermB, tetM, mefH, and various mutations in gyrA, gyrB, rpoB, pbp1, and pbp3. These findings highlight the widespread nature of AMR in C. difficile and its potential role in the spread of the bacterium.
Molecular Characterization Based on Whole-Genome Sequencing of Streptococcus pneumoniae in Children Living in Southwest China During 2017-2019.
The study identified the presence of erythromycin resistance gene erm(B) and tetracycline resistance gene tet(M) in Streptococcus pneumoniae isolates from children in Southwest China, highlighting the prevalence of resistance to these antibiotics.
Antimicrobial susceptibility, multilocus sequence typing, and virulence of listeria isolated from a slaughterhouse in Jiangsu, China.
The study identified tetracycline resistance genes tetA and tetM, erythromycin resistance genes ermA, ermB, and ermC, and the aminoglycoside resistance gene aac(6')-Ib in Listeria isolates from a slaughterhouse in Jiangsu, China.
Impact of Antibiotic Therapies on Resistance Genes Dynamic and Composition of the Animal Gut Microbiota.
The study examined the impact of antibiotic therapies on the dynamics and composition of resistance genes in the animal gut microbiota, identifying several AMR genes such as blaTEM, tetA, strA, strB, intI1, tetM, mel, floR, mcr-2, oqx B, tetC, tetG, tetO, tetW, tetX, ermB, ermF, sul1, sul2, and others, which were experimentally validated in Escherichia coli.
Molecular Typing and Antimicrobial Susceptibility Profiles of Streptococcus uberis Isolated from Sheep Milk.
The study identified resistance genes ermB, ermC, blaZ, tetM, tetO, and tetK in Streptococcus uberis isolates from sheep milk, contributing to resistance against erythromycin, penicillin, and tetracycline.
Genetic Characterization of Staphylococcus aureus From Subclinical Mastitis Cases in Dairy Cows in Rwanda.
The study identified the blaZ gene conferring penicillin resistance in 84% of the isolates, tet(K) or tetM genes for tetracycline resistance in 20% of the isolates, and the dfrG gene for trimethoprim resistance in 28% of the isolates.
Occurrence and spread of antibiotic-resistant bacteria on animal farms and in their vicinity in Poland and Ukraine-review.
The review highlights the presence of antibiotic-resistant bacteria and resistance genes in the environments of animal farms in Poland and Ukraine, emphasizing the spread of multidrug-resistant strains such as MRSA and Salmonella. Key resistance genes identified include blaTEM, blaPSE, floR, tetA, tetB, tetC, tetG, cat1, dfrA1, dfrA5, dfrA7, dfrA12, dfrA17, sul1, sul2, sul3, ermB, tetL, tetW, tetM, blaZ, mecA, qnrS1, qnrS3, qnrB10, qnrB19, blaCTX-M-25, and blaOXA-21.
Invasive Multidrug-Resistant emm93.0 Streptococcus pyogenes Strain Harboring a Novel Genomic Island, Israel, 2017-2019.
The study identified multidrug resistance in an emm93.0 Streptococcus pyogenes strain in Israel, including resistance to clindamycin, tetracycline, and trimethoprim/sulfamethoxazole. A novel genomic island containing resistance genes lsa(E), lnu(B), ant(6)-Ia, and aph(3')-IIIa was discovered.
Letter to the Editor: Importation of the First Bovine ST361 New Delhi Metallo-5 Positive Escherichia coli in Greece.
The study reports the first bovine ST361 NDM-5 positive Escherichia coli in Greece, highlighting the importation of multidrug-resistant strains and the need for continued surveillance.
Invasive Group B Streptococcal Disease in Neonates and Infants, Italy, Years 2015-2019.
The study identified the presence of ermB, tetO, and tetM genes in Streptococcus agalactiae strains, which conferred resistance to erythromycin, clindamycin, and tetracycline, respectively. The MDR CC-17 sub-clone was associated with increased resistance rates.
Characterization of Erysipelothrix rhusiopathiae Isolates from Diseased Pigs in 15 Chinese Provinces from 2012 to 2018.
The study identified the macrolide resistance gene erm(A)-like, the tetracycline resistance gene tet(M), and the streptogramin B resistance gene lsa(E) in Erysipelothrix rhusiopathiae isolates. Additionally, mutations in gyrA (86T-I) and parC (81S-I) were linked to quinolone resistance.
Prevalence of Vancomycin-Resistant Enterococci and Antimicrobial Residues in Wastewater and Surface Water.
The study identified vanA and vanB genes in vancomycin-resistant Enterococcus faecium isolates, along with tet(M) and erm(B) genes associated with tetracycline and macrolide resistance, respectively. Aminoglycoside resistance was mediated by aac(6′)-Ie-aph(2′)-Ia and aph(3′)-IIIa genes.
MALDI-TOF MS for rapid detection and differentiation between Tet(X)-producers and non-Tet(X)-producing tetracycline-resistant Gram-negative bacteria.
The study presents the MALDI Tet(X)-plus test, a rapid and reliable method for detecting Tet(X)-producers, non-Tet(X)-producing tetracycline-resistant, and tetracycline-susceptible Gram-negative bacteria. It identifies various tetracycline resistance genes such as tet(A), tet(B), tet(D), tet(G), tet(M), tet(X3), tet(X4), tet(X2)-tet(X6), tet(X3)-tet(X6), and TMexCD1-TOprJ1.
Molecular Characteristics of Streptococcus pyogenes Isolated From Chinese Children With Different Diseases.
The study identified ermB and tetM as the primary genes responsible for macrolide and tetracycline resistance in Streptococcus pyogenes isolates from Chinese children.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
High-Resolution Melting Analysis to Detect Antimicrobial Resistance Determinants in South African Neisseria gonorrhoeae Clinical Isolates and Specimens.
The study identified several AMR genes and mutations in N. gonorrhoeae, including bla TEM, tetM, rpsJ_V57M, gyrA_S91F, 16S_rRNA_C1192U, mtrR_G45D, penA_G545S, and penA_mosaic, which are associated with resistance to penicillin, tetracycline, ciprofloxacin, spectinomycin, azithromycin, cefixime, and ceftriaxone.
Antibiotic resistance genes in gut of breast-fed neonates born by caesarean section originate from breast milk and hospital ward air.
The study identifies multiple antibiotic resistance genes (ARGs) in the gut of breast-fed neonates born via cesarean section, primarily originating from breast milk and hospital ward air. Key ARGs include mecA, blaTEM, ampC, tetM, ermB, sul2, and aac(6)-Ib, which were detected in S. epidermidis isolates from neonatal faeces, colostrum, and ward air.
Occurrence and Antimicrobial Resistance of Enterococci Isolated from Goat's Milk.
The study identified several AMR genes in enterococci isolated from goat's milk, including ermB, vgaA, and tet(M), which confer resistance to erythromycin, virginiamycin, and tetracycline, respectively.
Whole genome sequence analyses-based assessment of virulence potential and antimicrobial susceptibilities and resistance of Enterococcus faecium strains isolated from commercial swine and cattle probiotic products.
The study identified several antimicrobial resistance (AMR) genes in Enterococcus faecium strains isolated from commercial swine and cattle probiotics, including aac(6')-Ii, aph(3')-III, ant(6)-Ia, tet(L), tet(M), msrC, and cat-(pc194). These genes confer resistance to aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramin B, and phenicols.
Multiple-locus variable-number tandem repeat analysis for genotyping of erythromycin-resistant group B streptococci in Iran.
The study identified ermTR, ermB, and tetM as the primary resistance genes in erythromycin-resistant group B streptococci (GBS) isolates from Iran, with ermTR and ermB being strongly associated with the constitutive MLSB phenotype.
Antimicrobial and Biocide Resistance among Feline and Canine Staphylococcus aureus and Staphylococcus pseudintermedius Isolates from Diagnostic Submissions.
The study identified various antimicrobial resistance genes in feline and canine Staphylococcus aureus and Staphylococcus pseudintermedius isolates, including blaZ, mecA, mecC, tet(K), tet(M), erm(A), erm(B), erm(C), erm(T), msr(A), aadE, aacA-aphD, aphA3, aadD, dfrG, lnu(B), and lsa(E). These genes conferred resistance to multiple antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, and others.
Molecular Epidemiology of Multidrug-Resistant Pneumococci among Ghanaian Children under Five Years Post PCV13 Using MLST.
The study identified the ermB, mefA, tetM, and pbp2b genes as the genetic basis for erythromycin, tetracycline, and penicillin resistance in multidrug-resistant pneumococci isolated from Ghanaian children.
Population structure of ocular Streptococcus pneumoniae is highly diverse and formed by lineages that escape current vaccines.
The study identifies macrolide resistance genes mefA, msrD, ermB, and tetracycline resistance gene tetM in ocular Streptococcus pneumoniae isolates, highlighting the prevalence of resistance to macrolides and tetracycline in this population.
Genomic epidemiology of Streptococcus agalactiae ST283 in Southeast Asia.
The study identified the tetracycline resistance gene tet(M) and the putative macrolide resistance gene mreA in Streptococcus agalactiae ST283. Experimental validation confirmed that tet(M) conferred tetracycline resistance, while mreA was found in all isolates but did not correlate with macrolide resistance.
Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome.
The study identifies 15 broad host range mobile genetic elements (MGEs) that can transfer antibiotic resistance genes between different bacterial phyla, including plasmids, integrative and conjugative elements (ICEs), and integrative and mobilizable elements (IMEs). Experimental validation shows that these MGEs can mobilize between commensals and pathogens, highlighting their potential role in antibiotic resistance dissemination.
Global evolutionary dynamics and resistome analysis of Clostridioides difficile ribotype 017.
The study identifies ermB, tetM, and aac6-aph2 as key AMR genes in C. difficile RT 017, highlighting their role in the global spread of multidrug-resistant strains.
Multidrug-Resistant Methicillin-Resistant Coagulase-Negative Staphylococci in Healthy Poultry Slaughtered for Human Consumption.
The study identified multiple multidrug-resistant methicillin-resistant coagulase-negative staphylococci (MRCoNS) in poultry, carrying genes such as mecA, ermA, ermB, ermC, mphC, aph(3')-IIIa, ant(4')-Ia, str, tetK, tetL, tetM, tetO, cfr, dfrK, dfrD, and cat p194, which confer resistance to various antibiotics.
A One Health Approach Molecular Analysis of Staphylococcus aureus Reveals Distinct Lineages in Isolates from Miranda Donkeys (Equus asinus) and Their Handlers.
The study identified various antimicrobial resistance genes in Staphylococcus aureus and coagulase-negative staphylococci (CoNS) isolates from Miranda donkeys and their handlers, including blaZ, aph(3')-IIIa, tetK, tetL, tetM, lnuA, ermB, ermC, mecA, and optrA. These genes confer resistance to penicillins, aminoglycosides, tetracyclines, lincomycins, macrolides, lincosamides, streptogramin B, methicillin, and linezolid.
Antimicrobial Resistance, Biofilm Formation, and Virulence Genes in Enterococcus Species from Small Backyard Chicken Flocks.
The study identified several antimicrobial resistance (AMR) genes in Enterococcus species isolated from backyard chickens, including ermB, ermA, tetM, tetL, vanA, cat, and pbp5. These genes were associated with resistance to erythromycin, tetracycline, vancomycin, chloramphenicol, and ampicillin.
Invited Review: Antimicrobial Use and Antimicrobial Resistance in Pathogens Associated with Diarrhea and Pneumonia in Dairy Calves.
The review identified several AMR genes in pathogens associated with calf diarrhea and pneumonia, including beta-lactamases (blaCMY, blaCTX-M, blaTEM), tetracycline resistance genes (tetA, tetB, tetM, tetO), aminoglycoside resistance genes (strA, strB, aadA), sulfonamide resistance genes (sul1, sul2), phenicol resistance genes (cat, floR), and macrolide/lincosamide resistance genes (cfr, ermB).
Beyond CC398: Characterisation of Other Tetracycline and Methicillin-Resistant Staphylococcus aureus Genetic Lineages Circulating in Spanish Hospitals.
The study characterizes various tetracycline and methicillin-resistant Staphylococcus aureus genetic lineages circulating in Spanish hospitals, identifying multiple AMR genes including blaZ, tetK, tetL, tetM, ermC, ermB, ant(4')-Ia, aac(6')-Ie-aph(2'')-Ia, mupA, and fusB.
Molecular Epidemiology and Antimicrobial Resistance of Clostridioides difficile in Hospitalized Patients From Mexico.
The study identified several AMR genes and mutations in C. difficile isolates from Mexico, including cfrE, ermB, aadE, aadA27, aac(6')-Ie-aph(2'')-Ia, catP, blaCDD2, blaCCD1, tetM, tetO, tetB, tetA, and cdeA, along with mutations in rpoB, rpoC, fusA, and pbp2 associated with resistance to various antibiotics.
Analysis of Antimicrobial Resistance in Non-typhoidal Salmonella Collected From Pork Retail Outlets and Slaughterhouses in Vietnam Using Whole Genome Sequencing.
The study identified several AMR genes in non-typhoidal Salmonella isolates from pork retail outlets and slaughterhouses in Vietnam, including blaTEM-1, blaTEM-150, blaLAP-2, blaCTX-M-55, dfrA12, dfrA14, floR, cmlA1, tetA, tetB, tetM, mcr-1, mcr-3, qnrS1, mphA, aadA1, aadA2, aac(6')-laa, aac(6')-ly, sul1, sul2, sul3, aph(3")-lb, and aph6-ld. These genes conferred resistance to various antibiotics such as ampicillin, penicillins, first-generation cephalosporins, quinolones, trimethoprim, chloramphenicol, tetracycline, colistin, macrolides, gentamicin, sulfonamides, and others.
Analysis of Salmonella enterica Isolated from a Mixed-Use Watershed in Georgia, USA: Antimicrobial Resistance, Serotype Diversity, and Genetic Relatedness to Human Isolates.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from a mixed-use watershed in Georgia, USA, including bla CMY-2, aadA2, strA, strB, sul1, sul2, tetA, tetC, floR, and dfrA12, which conferred resistance to various antibiotics such as ceftiofur, ceftriaxone, streptomycin, sulfisoxazole, tetracycline, chloramphenicol, and trimethoprim.
Dogs as carriers of virulent and resistant genotypes of Clostridioides difficile.
The study identified several AMR genes and mutations in C. difficile isolates from dogs, including erm(B), cfr(C), tet(M), and pCD-METRO, which confer resistance to erythromycin, clindamycin, tetracycline, and metronidazole, respectively.
Antimicrobial resistance-Do we share more than companionship with our dogs?
The study identified various antimicrobial resistance genes (ARGs) in fecal samples from dogs and their owners, highlighting the presence of tetracycline, MLS, aminoglycoside, and sulfonamide resistance genes. Dogs exhibited a higher diversity of aminoglycoside resistance genes compared to owners.
Characteristics of Streptococcus agalactiae Colonizing Nonpregnant Adults Support the Opportunistic Nature of Invasive Infections.
The study identified ermA, ermB, and mefE genes associated with macrolide resistance in Streptococcus agalactiae isolates from nonpregnant adults, along with tetM for tetracycline resistance and aph(3')-IIIa and ant(6)-Ia for streptomycin resistance.
Inverse PCR-based detection reveal novel mobile genetic elements and their associated genes in the human oral metagenome.
The study identified novel integron gene cassettes and variants of Tn 916 conjugative transposons in the human oral metagenome using an inverse PCR-based approach. It also discovered the presence of tetracycline resistance gene tet(M) and erythromycin resistance gene erm(B) associated with these mobile genetic elements.
Antimicrobial Susceptibility, and Molecular Characterization of Staphylococcus aureus Isolated From Different Raw Milk Samples in China.
The study identified several AMR genes in Staphylococcus aureus isolated from raw milk samples in China, including blaZ, aac(6')-aph(2"), tet(M), mecA, cfxA, ant(4')-Ia, and fexA. These genes conferred resistance to various antibiotics such as Penicillin G, Tetracycline, Gentamicin, Kanamycin, Cefoxitin, and Chloramphenicol.
Description of Staphylococcal Strains from Straw-Coloured Fruit Bat (Eidolon helvum) and Diamond Firetail (Stagonopleura guttata) and a Review of their Phylogenetic Relationships to Other Staphylococci.
The study describes the characterization of Staphylococcal strains from Straw-coloured fruit bats and a Diamond firetail, identifying them as belonging to the newly described species S. roterodami and S. singaporensis. The isolates exhibited unique genetic features and were found to be closely related to S. argenteus and S. schweitzeri.
Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance.
The paper discusses the resurgence of tetracycline-class antibiotics, highlighting their effectiveness against various bacterial infections, including those resistant to other antibiotics. It identifies key resistance mechanisms such as efflux pumps and ribosomal protection proteins, and emphasizes the importance of these antibiotics in combating multidrug-resistant pathogens.
Antibiotic resistance and virulence genes in Enterococcus species isolated from raw and processed seafood.
The study identified tetracycline resistance gene tet M, erythromycin resistance gene erm B, aminoglycoside resistance gene aac(6')-aph(2'')-la, and virulence genes agg 2 and gel E in Enterococcus species isolated from seafood.
Detection of Antibiotic Resistance, Virulence Gene, and Drug Resistance Gene of Staphylococcus aureus Isolates from Bovine Mastitis.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from bovine mastitis, including blaZ, aacA-aphD, tetK, tetM, norA, norB, norC, and mecA. These genes were associated with resistance to various antibiotics such as penicillin G, gentamicin, kanamycin, tetracycline, and ciprofloxacin.
Genetic background of Cambodian pneumococcal carriage isolates following pneumococcal conjugate vaccine 13.
The study identified multiple antimicrobial resistance (AMR) genes in Cambodian pneumococcal carriage isolates, including ermB, mefA, cat, tet(M), tet(O), folA, and folP, which confer resistance to erythromycin, chloramphenicol, tetracycline, trimethoprim, and sulfamethoxazole. These genes were validated through predictive resistance profiling using the CDC-AMR pipeline.
Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches.
The study identifies several AMR genes and mutations associated with resistance to various antibiotics in wastewater environments, highlighting the role of these genes in the spread of antimicrobial resistance.
Antimicrobial resistance and virulence factors in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis in low-resource settings
The study identifies various antimicrobial resistance genes in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis, including mecA, tet(K), tet(M), tet(L), aadD, aph(3)-III, ermA, ermC, msrA, mphC, and IS256. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in low-resource settings.
Assessment of multidrug-resistant Listeria monocytogenes in milk and milk product and One Health perspective.
The study identified multiple antimicrobial resistance genes in Listeria monocytogenes isolates from milk and milk products, including beta-lactamase genes (bla TEM, bla SHV, bla Z), tetracycline resistance genes (tet A, tet D, tet G, tet K, tet M), sulfonamide resistance genes (sul 1, sul 2), and an aminoglycoside resistance gene (aph (3)-IIa (aphA2)).
Biogeographical variation in antimicrobial resistance in rivers is influenced by agriculture and is spread through bacteriophages.
The study identifies the prevalence of tetracycline resistance genes (tetA and tetM) in both bacterial and phage populations in river water, highlighting the role of agricultural areas in promoting phage-induced resistance.
Genomic Characterization of Enterococcus hirae From Beef Cattle Feedlots and Associated Environmental Continuum.
The study identified several AMR genes in Enterococcus hirae isolates from beef cattle feedlots, including tetracycline resistance genes (tet(L), tet(M), tet(O), tet(S/M), tet(O/32/O)), macrolide resistance gene erm(B), and aminoglycoside resistance genes (aac(6')-Iid, ant(6)-Ia, aph(3')-III, sat4).
Genomic Characterization of Enterococcus hirae From Beef Cattle Feedlots and Associated Environmental Continuum.
The study identified several AMR genes in Enterococcus hirae isolates from beef cattle feedlots, including tetracycline resistance genes (tet(L), tet(M), tet(O), tet(S/M), tet(O/32/O)), macrolide resistance gene erm(B), and aminoglycoside resistance genes (aac(6')-Iid, ant(6)-Ia, aph(3')-III, sat4).
Genomic diversity of genus Limosilactobacillus.
The study identified 18 AMR genes in Limosilactobacillus species, primarily in L. reuteri from animal sources, including tetracycline, aminoglycoside, macrolide-lincosamide-streptogramin, and lincomycin resistance genes.
Antimicrobial resistance and genomic analysis of staphylococi isolated from livestock and farm attendants in Northern Ghana.
The study identified several AMR genes in staphylococci from livestock and farm attendants in Northern Ghana, including mecA1, mecA, tet(K), tet(L), tet(M), cat(pC221), sal(A), aadD, dfrK, dfrG, erm(B), fosB, aac(6')-aph(2''), and blaZ, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, aminoglycosides, and macrolides.
Antimicrobial Susceptibility Profiles and Molecular Characterisation of Staphylococcus aureus from Pigs and Workers at Farms and Abattoirs in Zambia.
The study identified tetracycline resistance genes (tetM, tetK, tetL) and erythromycin resistance genes (ermB, ermC) in Staphylococcus aureus isolates from pigs and workers in Zambia. These genes were detected through PCR and are associated with resistance to tetracycline and erythromycin, highlighting the need for continued surveillance of antimicrobial resistance in this region.
Antimicrobial-Resistant Enterococcus spp. in Wild Avifauna from Central Italy.
The study identified aac(6')-Ie-aph(2")-Ia, ant(6')-Ia, and tet(M) as key genes contributing to aminoglycoside and tetracycline resistance in Enterococcus spp. isolated from wild birds.
Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of drug resistance in Staphylococcus aureus, focusing on beta-lactam, glycopeptide, oxazolidinone, MLS-B, aminoglycoside, and other resistance mechanisms. Key genes identified include blaZ, mecA, mecC, vanA, cfr, ermA, ermC, aac(6')-Ib, aph(3')-IIIa, and aadD. Mutations in pbp2 and pbp2a were also found to contribute to resistance.
Methicillin Resistant Staphylococci Isolated from Goats and Their Farm Environments in Saudi Arabia Genotypically Linked to Known Human Clinical Isolates: a Pilot Study.
The study identified several AMR genes in methicillin-resistant staphylococci isolates from goats and their farm environments in Saudi Arabia, including mecA, blaZ, norA, lmrS, mepA, mepR, arlR, arlS, tet(38), mecR1, dfrC, fusC, fosB, fexA, tetM, msrA, mphC, fusB, APH(3′)-IIIa, tetK, and dfrG. These genes confer resistance to various antibiotics such as penicillins, fluoroquinolones, aminoglycosides, macrolides, phenicols, diaminopyrimidines, oxazolidinones, tetracyclines, and fosfomycin.
Characterization of Streptococcus pneumoniae Macrolide Resistance and Its Mechanism in Northeast China over a 20-Year Period.
The study identified the presence of ermB, mefA, and tetM genes in erythromycin-resistant Streptococcus pneumoniae strains in northeast China, highlighting the high prevalence of macrolide resistance mediated by these genes.
Antimicrobial susceptibilities and mechanisms of resistance of commensal and invasive Mycoplasma salivarium isolates.
The study identified mutations in 23S rRNA, 16S rRNA, gyrA, parC, and the presence of tetM gene as mechanisms of resistance to erythromycin, clindamycin, tetracycline, and levofloxacin in Mycoplasma salivarium isolates.
Tetracycline, Macrolide and Lincosamide Resistance in Streptococcus canis Strains from Companion Animals and Its Genetic Determinants.
The study identified tetracycline resistance genes tet(O), tet(M), and tet(T), and MLS resistance genes erm(B) and erm(TR) in Streptococcus canis strains from companion animals.
Tigecycline-resistant Escherichia coli ST761 carrying tet(X4) in a pig farm, China.
The study identifies tet(X4) as a major cause of tigecycline resistance in E. coli ST761 isolates from a pig farm in China. The gene is located on a hybrid plasmid and is part of a multidrug resistance region that includes other resistance genes such as blaTEM-1, tet(A), tet(M), floR, qnrS1, sul3, dfrA5, and mef(B).
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Nasal Staphylococcus aureus and S. pseudintermedius carriage in healthy dogs and cats: a systematic review of their antibiotic resistance, virulence and genetic lineages of zoonotic relevance.
The study identifies various AMR genes such as mecA, blaZ, tet(M), erm(B), aac(6')-aph(2"), aadD, ant(6)-Ia, and sat4 in Staphylococcus aureus and S. pseudintermedius isolates from healthy dogs and cats, indicating widespread antibiotic resistance.
Diversity and emergence of multi-resistant Staphylococcus spp. isolated from subclinical mastitis in cows in of the state of Piauí, Brazil.
The study identified the presence of blaZ, tetL, tetM, mecA, and vanB genes in Staphylococcus spp. isolates from subclinical mastitis in cows in Piauí, Brazil, indicating multidrug resistance.
Multidrug-Resistant Bacteria: Their Mechanism of Action and Prophylaxis.
The paper reviews the mechanisms of multidrug resistance in bacteria, focusing on resistance mechanisms such as beta-lactamases, vancomycin resistance genes, and other resistance determinants in both Gram-positive and Gram-negative bacteria.
Molecular characterization and biofilm-formation analysis of Listeria monocytogenes, Salmonella spp., and Escherichia coli isolated from Brazilian swine slaughterhouses.
The study identified various antimicrobial resistance genes in E. coli and Salmonella Typhi isolates from Brazilian swine slaughterhouses, including ampC, blaSHV, cat1, clmA, MCR-1, MCR-3, tet(A), tet(B), tet(C), tet(M), and sulI. These genes conferred resistance to multiple antibiotics such as ampicillin, amoxicillin, chloramphenicol, tetracycline, doxycycline, colistin, and sulfonamide.
Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents.
The study identifies various AMR genes in Enterococcus faecium, including vanA, vanB, ermB, ermT, ermA, aad(6), aph(3')-IIIa, aac(6')-Ie-aph(2')-Ia, sat-4, tetM, tet(W/N/W), dfrG, dfrF, lnuB, optrA, and lsaE, which are associated with different habitats and geographic locations.
Molecular Typing Reveals Environmental Dispersion of Antibiotic-Resistant Enterococci under Anthropogenic Pressure.
The study identified multiple antibiotic resistance genes in Enterococcus isolates from various aquatic environments, highlighting the role of anthropogenic pressure in the spread of antibiotic-resistant enterococci.
Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock.
The study identified qnrS1 as a quinolone resistance gene present in both broiler chicken and human samples, indicating potential transmission between these hosts.
Withdrawal of antibiotic growth promoters in China and its impact on the foodborne pathogen Campylobacter coli of swine origin.
The study found that the withdrawal of antibiotic growth promoters in China led to an increase in antibiotic resistance in Campylobacter coli, particularly for gentamicin and florfenicol. Several resistance genes, including aadE-Cc, aac(6')-aph(2"), ant(6)-la, aph(3")-lll, aph(2")-lf, tet(O), tet(M), tet(O/32/O), cat, fexA, cfr(C), optrA, blaOXA-193, blaOXA-489, and blaOXA-61, were identified. Mutations in 23S rRNA and gyrA were also associated with resistance to erythromycin and ciprofloxacin, respectively.
Antimicrobial Resistance, Virulence Profiles, and Public Health Significance of Enterococcus faecalis Isolated from Clinical Mastitis of Cattle in Bangladesh.
The study identified tetracycline resistance genes tetK, tetL, and tetM, as well as aminoglycoside resistance genes aacC2, aacC4, and aph(3'')-IIIa, and the vancomycin resistance gene vanB in Enterococcus faecalis isolates from bovine clinical mastitis in Bangladesh.
Characterization and Transferability of erm and tet Antibiotic Resistance Genes in Lactobacillus spp. Isolated from Traditional Fermented Milk.
The study identifies the presence of erm(B) and tet(M) antibiotic resistance genes in Lactobacillus spp. isolated from traditional fermented milk, highlighting their potential to transfer resistance to pathogenic bacteria.
Antibiotic resistance and pathogenicity assessment of various Gardnerella sp. strains in local China.
The study identified antibiotic resistance genes ermX, lsaC, tetL, and tetM in Gardnerella strains, with seven strains showing strong resistance to metronidazole.
Longitudinal Analysis of Antimicrobial Resistance among Enterococcus Species Isolated from Australian Beef Cattle Faeces at Feedlot Entry and Exit.
Antimicrobial susceptibility to polymyxin B and other comparators against Gram-negative bacteria isolated from bloodstream infections in China: Results from CARVIS-NET program.
The study found that 94.1% of the 1939 Gram-negative isolates were susceptible to polymyxin B, and the sensitivity of the strains to polymyxin B was highly correlated with their sensitivity to colistin.
Comparative Analysis of the Molecular Characteristics of Group B Streptococcus Isolates Collected from Pregnant Korean Women Using Whole-genome Sequencing.
The study identified ermB, ermA, tetM, and tetO as genes conferring resistance to erythromycin and tetracycline in Group B Streptococcus isolates from pregnant Korean women.
Emergence of Cfr-Mediated Linezolid Resistance among Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) from Healthy Pigs in Portugal.
The study identified the cfr gene as a mediator of linezolid resistance in livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) from healthy pigs in Portugal. Additional resistance genes such as blaZ, mecA, fexA, tet(M), and tet(K) were also characterized.
Antimicrobial Resistance and Virulence Genes in Staphylococci Isolated from Aviary Capercaillies and Free-living Birds in South-eastern Poland.
The study identified several AMR genes in Staphylococcus isolates from birds, including mecA, blaZ, msrA/B, ermC, mphC, tetK, tetM, cfr, norA, aac(6')-aph(2"), sea, and tst. These genes conferred resistance to various antibiotics such as methicillin, beta-lactams, macrolides, tetracyclines, chloramphenicol, florfenicol, fluoroquinolones, and aminoglycosides.
Current Susceptibility Surveillance and Distribution of Antimicrobial Resistance in N. gonorrheae within WHO Regions.
The study characterizes the molecular mechanisms of antimicrobial resistance in Neisseria gonorrhoeae, highlighting the role of specific genes and mutations in conferring resistance to various antibiotics, including extended-spectrum cephalosporins, fluoroquinolones, and macrolides.
Detection and Genomic Characterisation of Clostridioides difficile from Spinach Fields.
The study identified various antimicrobial resistance genes in C. difficile isolates from spinach and soil samples, including vanB, tet(M), ant(6)-Ia, qacG, cdeA, SAT-4, vanXY, vanR, D19aph(3')-III_1, tet(40), and CDD-1, indicating resistance to vancomycin, tetracyclines, aminoglycosides, disinfectants, fluoroquinolones, nucleosides, and beta-lactams.
Web-based prediction of antimicrobial resistance in enterococcal clinical isolates by whole-genome sequencing.
The study evaluated the accuracy of whole-genome sequencing (WGS) for predicting antimicrobial resistance in enterococcal clinical isolates. It identified several AMR genes and mutations, including aac(6')-aph(2"), erm(B), erm(T), tet(L), tet(M), vanA, vanB, vanD, optrA, poxtA, and mutations in gyrA and parC, which were validated through genomic sequencing and phenotypic AST.
Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcus aureus from Nasal Specimens: Overcoming MRSA with Silver Nanoparticles and Their Applications.
The study identified methicillin-resistant Staphylococcus aureus (MRSA) isolates carrying resistance genes mecA, aacA-aphD, tetM, ermA, tetK, and vatABC. These genes conferred resistance to multiple antibiotics, including methicillin, tetracycline, aminoglycosides, and macrolides. The study also highlighted the potential of silver nanoparticles in enhancing the efficacy of antibiotics against MRSA.
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
The study identified ESBL-producing E. coli in river water in northern Thailand, with bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27 being the most prevalent beta-lactamase genes. Additionally, mcr-1.1 and mcr-3.4 genes were found to confer resistance to colistin. Various other resistance genes were also characterized, including aac(3)-IId, aadA5, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, aac(6′)-Ib-cr, qnrS1, mdf(A), erm(B), mph(A), floR, sul2, sul3, tet(A), tet(X), tet(M), dfrA12, dfrA14, dfrA17, cmlA1, catA2, lnu(F), and erm(42).
Antimicrobial resistance: mechanisms and implications
The review discusses various molecular mechanisms of antibiotic resistance, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and efflux pumps, highlighting their roles in conferring resistance to multiple antibiotics.
Concordance between Antimicrobial Resistance Phenotype and Genotype of Staphylococcus pseudintermedius from Healthy Dogs.
The study identified 17 antibiotic resistance genes in Staphylococcus pseudintermedius isolates from healthy dogs, including blaZ, mecA, ermB, tetM, aac(6')-aph(2''), ant(6)-Ia, aph(3')-IIIa, spw, str, and dfrG. It also found mutations in gyrA and parC genes associated with fluoroquinolone resistance, and mutations in rpoB and clpP linked to vancomycin resistance.
Distribution Patterns of Antibiotic Resistance Genes and Their Bacterial Hosts in a Manure Lagoon of a Large-Scale Swine Finishing Facility.
The study identified multiple antibiotic resistance genes (ARGs) in manure samples from a swine finishing facility, highlighting the prevalence of resistance to tetracyclines, macrolides, aminoglycosides, and other antibiotics. Key genes included tet(M), lnuA, erm(35), aadS, mphB, dfrG, vga-type ABC-F, lsa-type ABC-F, msr-type ABC-F, optrA, and others, primarily found in Firmicutes, Proteobacteria, and Bacteroidota. These genes were associated with resistance mechanisms such as target alteration, antibiotic inactivation, and efflux pumps.
Prevalence, Infectious Characteristics and Genetic Diversity of Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus (MRSA) in Two Raw-Meat Processing Establishments in Northern Greece.
The study identified several AMR genes including mecA, blaZ, fexA, tetM, and dfrC in Staphylococcus aureus isolates from meat-processing establishments in Greece. These genes conferred resistance to methicillin, beta-lactams, chloramphenicol, tetracycline, and trimethoprim, respectively.
Detection of Methicillin-Resistant Staphylococcus aureus in Clinical and Subclinical Mastitis in Ruminants and Studying the Effect of Novel Green Synthetized Nanoparticles as One of the Alternative Treatments.
The study identified methicillin-resistant Staphylococcus aureus (MRSA) in mastitic milk samples from ruminants and characterized resistance genes including mecA, blaZ, ermB, tetM, and tetK. Green synthesized titanium dioxide nanoparticles (TiO2 NPs) showed potent antibacterial activity against MRSA.
The hazard of carbapenemase (OXA-181)-producing Escherichia coli spreading in pig and veal calf holdings in Italy in the genomics era: Risk of spill over and spill back between humans and animals.
The study identifies multiple AMR genes, including bla OXA-181, bla TEM-1B, aac (3)-IId, aad A2, cml A1, dfr A12, mef (B), sul 3, tet (A), tet (M), incX3, incX1, incFII, qnr S1, aph (3″)-Ib, aph (6)-Id, flo R, lnu (F), sul 2, sul 3, tet (B), mph (A), mph (G), qnr B4, rmt B, and fos A3, in OXA-181-producing E. coli isolates from pigs and bovines in Italy. These genes confer resistance to various antibiotics, including carbapenems, cephalosporins, penicillins, aminoglycosides, trimethoprim, macrolides, sulfonamides, tetracyclines, fluoroquinolones, and fosfomycin.
Association of CRISPR-Cas System with the Antibiotic Resistance and Virulence Genes in Nosocomial Isolates of Enterococcus.
The study found that the CRISPR-Cas system is associated with reduced antibiotic resistance and virulence in Enterococcus isolates. Specific resistance genes such as ermB, aadE, ant(6), aac(6')-aph(2"), tetM, and vanA were identified in the isolates.
Dispersion and persistence of antimicrobial resistance genes among Staphylococcus spp. and Mammaliicoccus spp. isolated along a swine manure treatment plant.
The study identified multiple antimicrobial resistance genes, including fexA, ermC, cfr, aac(6')-aph(2''), dfrG, tetK, blaZ, mecA, norA, tetM, and ermA, in Staphylococcus and Mammaliicoccus species isolated from a swine manure treatment plant, indicating widespread resistance to various antibiotics.
Genetic characteristics, antimicrobial resistance, and prevalence of Arcobacter spp. isolated from various sources in Shenzhen, China.
The study identified several AMR genes in Arcobacter spp., including beta-lactamase genes (blaOXA464, blaOXA491), tetracycline resistance genes (tet(L), tet(H), tet(M)), a macrolide resistance gene (ere(A)), and aminoglycoside resistance genes (APH(3')-IIIa, ant(6)-Ia, SAT-4). Additionally, a mutation in the gyrA gene (C254T) was found to confer fluoroquinolone resistance.
Rothia nasimurium as a Cause of Disease: First Isolation from Farmed Chickens.
Rothia nasimurium was isolated from chickens for the first time and found to exhibit multidrug resistance, carrying 13 resistance genes including bla TEM, bla CTX-M, mecA, sul1, sul2, sul3, aac(6′)-Ib, gyrA, aph(3′)-Ia, tet(A), tetM, and ermB.
Methicillin-Resistant Staphylococcus aureus from Diabetic Foot Infections in a Tunisian Hospital with the First Detection of MSSA CC398-t571.
The study identified several AMR genes in S. aureus isolates from diabetic foot infections, including blaZ, erm(B), erm(A), msrA, tet(M), tet(K), tet(L), aac(6')-aph(2"), ant(4')-Ia, and fexA. These genes conferred resistance to various antibiotics such as penicillin, erythromycin, tetracycline, gentamicin, tobramycin, and chloramphenicol.
Characteristics of Staphylococcus aureus Isolated from Patients in Busia County Referral Hospital, Kenya.
The study identified S. aureus isolates carrying genes conferring resistance to penicillin-G, trimethoprim, tetracycline, erythromycin, gentamicin, and other antibiotics. Key resistance genes included blaZ, tetK, tetM, dfrG, ermA, ermC, aacA-aphD, aad9, and mecA.
ggMOB: Elucidation of genomic conjugative features and associated cargo genes across bacterial genera using genus-genus mobilization networks.
The study identifies various conjugative features and associated cargo genes, highlighting the significant role of conjugation in the spread of antimicrobial resistance (AMR) across bacterial genera. Key AMR genes such as Tn916, CTn341, SXT, ICEEc2, ICEclc, Tn1549, and Tn4555 were found to be prevalent in conjugative genomes, demonstrating their involvement in the dissemination of resistance traits.
Resistome and virulome diversity of foodborne pathogens isolated from artisanal food production chain of animal origin in the Mediterranean region.
The study identified various AMR genes in L. monocytogenes, Salmonella enterica, and S. aureus isolates from artisanal food production chains in the Mediterranean region, highlighting the presence of fosfomycin, aminoglycoside, beta-lactam, trimethoprim, sulfonamide, tetracycline, and streptomycin resistance mechanisms.
Dissemination and characteristics of high-level erythromycin-resistant Enterococcus faecalis from bulk tank milk of dairy companies in Korea.
The study identified several AMR genes, including ermB, tetM, tetL, optrA, aac(6')-Ie-aph(2'')-la, ant(6')-Ia, and Int-Tn, in high-level erythromycin-resistant Enterococcus faecalis isolates from bulk tank milk in Korea.
Microbiological Biodiversity of Regional Cow, Goat and Ewe Milk Cheeses Produced in Poland and Antibiotic Resistance of Lactic Acid Bacteria Isolated from Them.
The study identified tetracycline, erythromycin, and chloramphenicol resistance genes in lactic acid bacteria isolated from regional cheeses in Poland.
Staphylococcus microti Strains Isolated from an Italian Mediterranean Buffalo Herd.
The study identified S. microti strains isolated from buffalo milk and milking parlor surfaces, which exhibited 100% resistance to tetracycline and oxytetracycline, mediated by the tetM gene.
Expanded catalogue of metagenome-assembled genomes reveals resistome characteristics and athletic performance-associated microbes in horse.
The study identified a diverse array of antibiotic resistance genes (ARG) in the horse gut microbiome, highlighting the widespread use of antibiotics in horse management. The resistome characteristics were analyzed alongside the identification of microbes associated with athletic performance.
Antibiotic resistance genes and molecular typing of Streptococcus agalactiae isolated from pregnant women.
The study identified several antibiotic resistance genes in Streptococcus agalactiae isolates from pregnant women, including ermB, mefA/E, ermTR, tetM, tetO, and aphA3, which confer resistance to macrolides, tetracyclines, and aminoglycosides.
Clostridioides difficile in South American Camelids in Germany: First Insights into Molecular and Genetic Characteristics and Antimicrobial Resistance.
The study identified several AMR genes and mutations in C. difficile isolates from South American camelids in Germany, including bla_CDD-1, vanZ1, aadE, tet(M), tet(40), vanG, vanR, vanS, vanT, and mutations in gyrA and gyrB associated with fluoroquinolone resistance.
Taxonomic Assignment-Based Genome Reconstruction from Apical Periodontal Metagenomes to Identify Antibiotic Resistance and Virulence Factors.
The study identified several antibiotic resistance genes (ARGs) in metagenomic assemblies from apical periodontal infections, highlighting the presence of multidrug resistance mechanisms in Enterobacter and Pseudomonas species.
Farming Practice Influences Antimicrobial Resistance Burden of Non-Aureus Staphylococci in Pig Husbandries.
The study found that organic and alternative pig farming practices are associated with reduced antimicrobial resistance (AMR) in non-aureus staphylococci (NAS) compared to conventional farming. Specific AMR genes such as mecA, blaZ, blaPC1, and others were more prevalent in conventional farms, while organic farms showed lower levels of AMR genes for aminoglycosides, phenicols, and tetracyclines.
Molecular Epidemiology of Group B Streptococcus Isolates from Pregnant Women with Premature Rupture of Membranes in Fuzhou, China.
The study identified several AMR genes in GBS isolates from pregnant women with PROM in Fuzhou, China, including mreA, ermB, mefA, mefE, ermA, ermTR, tetM, and tetK, which are associated with resistance to erythromycin and tetracycline.
Molecular epidemiology, drug resistance, and virulence gene analysis of Streptococcus agalactiae isolates from dairy goats in backyard farms in China.
The study identified multiple AMR genes in S. agalactiae isolates from dairy goats in China, including pbp2b, tetL, tetM, tetK, tetO, ermA, ermB, mefA, aphA3, aad6, lnu(B), gryA, and parC, which confer resistance to various antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, lincosamides, and quinolones.
Virulence and antibiotic-resistance genes in Enterococcus faecalis associated with streptococcosis disease in fish.
The study identified various antibiotic-resistance genes in three strains of Enterococcus faecalis associated with streptococcosis in fish, including genes conferring resistance to tetracycline, macrolide-lincosamide-streptogramin, and vancomycin.
Predominance of High-Level Tetracycline-Resistant Neisseria gonorrhoeae in Kenya: Implications for Global Implementation of Doxycycline Postexposure Prophylaxis for Prevention of Sexually Transmitted Infections.
High-level tetracycline resistance in Neisseria gonorrhoeae, mediated by the tet(M) gene, was prevalent among Kenyan women, potentially affecting the efficacy of doxycycline post-exposure prophylaxis.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Root canal microbiota as an augmented reservoir of antimicrobial resistance genes in type 2 diabetes mellitus patients.
The study identifies that root canal microbiota in T2DM patients harbor a higher prevalence of antimicrobial resistance genes (ARGs) compared to non-diabetic patients, particularly for tetW, tetM, ermB, ermC, cfxA, and tetQ.
Molecular characterization of Arcobacter butzleri isolates from poultry in rural Ghana.
The study identified several antimicrobial resistance genes in Arcobacter butzleri isolates from poultry in Ghana, including blaOXA-464, tetM, ermB, and others, highlighting the presence of multidrug-resistant strains and the potential for horizontal and vertical transmission of resistance genes.
Emergence of high-level colistin resistance mediated by multiple determinants, including mcr-1.1, mcr-8.2 and crrB mutations, combined with tigecycline resistance in an ST656 Klebsiella pneumoniae.
The study reports a highly drug-resistant ST656 Klebsiella pneumoniae strain, KP15-652, exhibiting high-level colistin resistance mediated by mcr-1.1, mcr-8.2, and crrB mutations, alongside tigecycline resistance conferred by tmexCD1-toprJ1, tet(A), and tet(M).
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteria.
The study identified several acquired and intrinsic antimicrobial resistance genes in lactic acid bacteria and bifidobacteria, including tetW, ANT(6)-Ia, aac(6')-Ie-APH(2'')-Ia, erm(B), erm(49), cat, dfrG, arr-4, and fosXCC. Additionally, mutations in S12, rsmG, Lsa(A), MsrC, and PBP5 were associated with resistance to various antibiotics.
Comparative Genome Analysis of Enterococcus cecorum Reveals Intercontinental Spread of a Lineage of Clinical Poultry Isolates.
The study identifies six genes associated with avian clinical isolates of Enterococcus cecorum, which can help distinguish them from nonclinical isolates.
Genetic determinants of macrolide and tetracycline resistance in penicillin non-susceptible Streptococcus pneumoniae isolates from people living with HIV in Dar es Salaam, Tanzania.
The study identified erm(B) and mef(A)-msr(D) as common genes conferring resistance to macrolides and clindamycin, while tet(M) was responsible for tetracycline resistance in penicillin non-susceptible Streptococcus pneumoniae isolates from HIV patients in Tanzania.
An in-house 45-plex array for the detection of antimicrobial resistance genes in Gram-positive bacteria.
The study describes an in-house 45-plex array for detecting antimicrobial resistance genes in Gram-positive bacteria, identifying optrA, poxtA, and vanA as significant resistance markers in Enterococcus and Staphylococcus isolates.
Genetic Organization of Acquired Antimicrobial Resistance Genes and Detection of Resistance-Mediating Mutations in a Gallibacterium anatis Isolate from a Calf Suffering from a Respiratory Tract Infection.
The study identified multiple acquired antimicrobial resistance genes and resistance-mediating mutations in a Gallibacterium anatis isolate from a calf with a respiratory tract infection, highlighting the potential for this bacterium to serve as a reservoir for antimicrobial resistance genes.
Correlations among Antibiotic Resistance Genes, Mobile Genetic Elements and Microbial Communities in Municipal Sewage Treatment Plants Revealed by High-Throughput Sequencing.
The study identifies various tetracycline resistance genes (tetC, tetE, tetG, tetM, tetO, tetQ, tetW, tetX), sulfonamide resistance gene (sulI), aminoglycoside resistance genes (ant(2')-Ia, ant(3')-Ia, aph(6')-Id, aph(33')-Ib, aac(6')-Ib), beta-lactam resistance genes (blaGES, blaVEB), chloramphenicol resistance gene (catB3), MLS resistance genes (ereA, ermB), and multidrug resistance genes (acrB, mexB, mexF) in municipal sewage treatment plants, highlighting their association with mobile genetic elements and microbial communities.
Antimicrobial Resistance and Virulence Genes of Streptococcus Agalactiae Isolated from Mastitis Milk Samples in China.
The study identified several AMR genes in multidrug-resistant Streptococcus agalactiae isolates from bovine mastitis milk samples in China, including ermB, ermA, lnuA, tetM, tetK, tetS, and tetO. These genes conferred resistance to macrolides, lincosamides, and tetracyclines.
Multidrug-resistant extended spectrum β-lactamase (ESBL)-producing Escherichia coli from farm produce and agricultural environments in Edo State, Nigeria.
The study identified various AMR genes in ESBL-producing E. coli isolates from agricultural farms and open markets in Edo State, Nigeria, including blaTEM, blaCTX-M-1, blaCTX-M-15, tetM, tetA, tetB, sul1, sul2, sul3, ant(4')-Ia, aacC(3)-1, qnrA, qnrB, qnrC, qnrS, cat::pC194, cat::pC221, intI1, and intI2. These genes conferred resistance to multiple antibiotics, indicating the presence of multidrug-resistant E. coli in the studied environments.
Dissemination of Tn916-Related Integrative and Conjugative Elements in Streptococcus pneumoniae Occurs by Transformation and Homologous Recombination in Nasopharyngeal Biofilms.
The study identifies tetM and ermB as genes conferring tetracycline and erythromycin resistance, respectively, in Streptococcus pneumoniae. These genes are part of Tn2009 and Tn2010, which are disseminated through transformation and homologous recombination in nasopharyngeal biofilms.
Intra-host variation of genetic lineages or AMR genotypes of CoPS
The study identifies various AMR genes including blaZ, dfrA, dfrG, ermB, catA, aac6′-aph2″, tet(M), dfrK, and ant4′ in Staphylococcus aureus and Staphylococcus pseudintermedius isolates. Additionally, a mutation in grlA (S80F) was found to confer fluoroquinolone resistance.
Phenotypic and genotypic survey of antibiotic resistance in Salmonella enterica isolates from dairy farms in Uruguay.
The study identified 21 AMR genes in Salmonella enterica isolates from dairy farms in Uruguay, including genes conferring resistance to aminoglycosides, tetracyclines, sulfonamides, beta-lactams, and quinolones. Two chromosomal mutations, parC_T57S and acrB_R717Q, were also detected, contributing to resistance against quinolones and azithromycin, respectively.
Enterococcal Linear Plasmids Adapt to Enterococcus faecium and Spread within Multidrug-Resistant Clades.
The study identifies pELF1-like plasmids in Enterococcus faecium that carry multiple antimicrobial resistance genes, including vancomycin resistance determinants, aminoglycoside resistance genes, macrolide resistance genes, tetracycline resistance genes, and oxazolidinone resistance genes. These plasmids are associated with multidrug-resistant clades and demonstrate high stability and self-transmissibility.
Detection of antibiotic-resistant canine origin Escherichia coli and the synergistic effect of magnolol in reducing the resistance of multidrug-resistant Escherichia coli.
The study identified multiple antibiotic resistance genes in canine-derived E. coli, including blaTEM-1, aac(6')-Ib-cr, TetA, Sul, blaCTX-M-1, QnrS, and TetM. It also demonstrated that magnolol enhances the susceptibility of multidrug-resistant E. coli to cefquinome.
A survey on antimicrobial resistance genes of frequently used probiotic bacteria, 1901 to 2022.
The study identified various antimicrobial resistance genes in probiotic bacteria, highlighting the presence of mobile genetic elements and the potential for horizontal gene transfer.
The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China.
The study identifies multiple antimicrobial resistance genes in Salmonella enterica isolates from China, highlighting the increasing prevalence of resistance to beta-lactams, quinolones, tetracyclines, and sulfonamides. Key genes include blaTEM-1B, blaCTX-M-14, aac(3)-IV, and mcr-1.
Distribution analysis of tetracycline resistance genes in Escherichia coli isolated from floor surface and effluent of pig slaughterhouses in Banten Province, Indonesia.
The study identified the distribution of tetracycline resistance genes (tetA, tetB, tetC, tetE, tetM, tetO, and tetX) in Escherichia coli isolates from pig slaughterhouses in Banten Province, Indonesia. The tetO gene was the most dominant in floor surface samples, while tetA was dominant in effluent samples.
Efflux Pumps and Different Genetic Contexts of tet(X4) Contribute to High Tigecycline Resistance in Escherichia fergusonii from Pigs.
The study identifies the tet(X4) gene and other tetracycline resistance genes, along with efflux pumps, as contributors to high tigecycline resistance in E. fergusonii from pigs.
Antibiotic-Resistant Desulfovibrio Produces H(2)S from Supplements for Animal Farming.
The study identifies multiple antibiotic resistance genes in Desulfovibrio vulgaris L2, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and mercury resistance genes, highlighting its potential role in spreading antibiotic resistance in agricultural environments.
Species Delineation and Comparative Genomics within the Campylobacter ureolyticus Complex.
The study identified several antimicrobial resistance genes in Campylobacter ureolyticus, including ermA, tetM, blaOXA-85, and aac(6')-aph(2''). These genes confer resistance to macrolides, tetracyclines, beta-lactams, and aminoglycosides, respectively.
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
The study identified numerous antimicrobial resistance (AMR) genes in methicillin-resistant Staphylococcus aureus (MRSA) CC398 isolates from diseased swine in Germany, including beta-lactam, tetracycline, macrolide, lincosamide, streptogramin B, phenicol, aminoglycoside, and fluoroquinolone resistance genes. These genes were often located on small transposons or plasmids, contributing to the multidrug resistance profile of the isolates.
Correlation between Bacterial Cell Density and Abundance of Antibiotic Resistance on Milking Machine Surfaces Assessed by Cultivation and Direct qPCR Methods.
The study identified the tetM gene as a significant contributor to tetracycline resistance in bacterial populations on milking machine surfaces, highlighting its prevalence through qPCR analysis.
The oral microbiota is a reservoir for antimicrobial resistance: resistome and phenotypic resistance characteristics of oral biofilm in health, caries, and periodontitis.
The study identified various antimicrobial resistance genes (ARGs) in the oral microbiota, including mefA, msrD, ermB, ermF, cfxA, blaCSP(1), tetM, tetQ, and pgpB, which confer resistance to antibiotics such as erythromycin, azithromycin, penicillin, ampicillin, tetracycline, and colistin. These genes were found in multiple bacterial species and were associated with different resistotypes in healthy, caries, and periodontitis groups.
Evolution, persistence, and host adaption of a gonococcal AMR plasmid that emerged in the pre-antibiotic era.
The study identifies tetM as a gene on the pConj plasmid that confers tetracycline resistance in Neisseria gonorrhoeae. The plasmid is highly conserved and persists in gonococcal populations despite the cessation of tetracycline use.
Microbiological Epidemiology of Invasive Infections Due to Non-Beta-Hemolytic Streptococci, France, 2021.
The study characterizes AMR genes and mutations in non-beta-hemolytic streptococci, highlighting high resistance rates to beta-lactams, MLS, and tetracyclines, with specific resistance mechanisms involving erm(A), erm(B), lnu(C), lsa(A), meff, and tet(M).
Antibiotic resistance in potential probiotic lactic acid bacteria of fermented foods and human origin from Nigeria.
The study identified various antibiotic resistance genes including aac(6')-Ii, ermB, ermC, tetM, vanE, and parC in lactic acid bacteria from Nigerian fermented foods and human sources.
Antimicrobial Resistance of Lactic Acid Bacteria from Nono, a Naturally Fermented Milk Product.
The study identified tetracycline resistance genes tet(S) and tet(M) in Enterococcus thailandicus 52 and Streptococcus infantarius 10, as well as the streptomycin resistance gene aad(E) in Enterococcus thailandicus 52. These genes were shown to be transferable to Enterococcus faecalis JH2-2.
Wastewater treatment plants, an "escape gate" for ESCAPE pathogens.
The study identifies several AMR genes and mutations in various pathogens found in wastewater treatment plants, highlighting the role of these facilities as reservoirs for antibiotic-resistant bacteria and genes.
A Genomic Snapshot of Antibiotic-ResistantEnterococcus faecalis within Public Hospital Environments in South Africa.
The study identified tet(M) and erm(B) as the most common antibiotic-resistant genes in Enterococcus faecalis isolates from South African hospitals, along with other resistance genes such as dfrG, catA, and optrA.
Antimicrobial resistance in bacteria isolated from peridomestic Rattus species: A scoping literature review.
This scoping review identifies various antimicrobial resistance (AMR) genes in bacteria isolated from peridomestic Rattus species, including beta-lactamases (bla TEM, bla CTX-M, bla SHV, bla VIM, bla IMP, bla NDM-1), aminoglycoside resistance genes (strA, strB, aadA, aphA), sulfonamide resistance genes (sul1, sul2, sul3), tetracycline resistance genes (tetA, tetB, tet34), trimethoprim resistance genes (dfrA1, dfrA17, dfr14), quinolone resistance genes (qnrB1), and others.
The Genetic Diversity and Antimicrobial Resistance of Pyogenic Pathogens Isolated from Porcine Lymph Nodes.
The study identified tetracycline resistance genes tetM and tetO, and erythromycin resistance gene ermB in Streptococcus dysgalactiae isolates from porcine lymph nodes.
Methicillin-Resistant Staphylococcus aureus Strains Isolated from Burned Patients in a Tunisian Hospital: Molecular Typing, Virulence Genes, and Antimicrobial Resistance.
The study identified several AMR genes in MRSA isolates from burned patients, including blaZ, erm(C), msr(A), and tet(M), which confer resistance to penicillin, erythromycin, and tetracycline.
Analysis of Antibiotic-Resistant and Virulence Genes of Enterococcus Detected in Calf Colostrum-One Health Perspective.
The study identified multiple antibiotic-resistant genes in Enterococcus isolates from bovine colostrum, including tet(K), tet(L), tet(M), erm(B), and ant(6)-Ia, which confer resistance to tetracycline, erythromycin, and streptomycin. High rates of multidrug resistance were observed.
Evaluation of Enterotoxins and Antimicrobial Resistance in Microorganisms Isolated from Raw Sheep Milk and Cheese: Ensuring the Microbiological Safety of These Products in Southern Brazil.
The study identified several antimicrobial resistance genes, including tetM, ermB, strA, tetL, sul1, sul2, and AAC(6)', in Staphylococcus spp. isolated from raw sheep milk and cheese in southern Brazil. These genes conferred resistance to various antibiotics, highlighting the prevalence of antimicrobial resistance in these microorganisms.
Occurrence of antimicrobial-resistant Staphylococcus aureus in a Brazilian veterinary hospital environment.
The study identified several AMR genes in Staphylococcus aureus isolates from a Brazilian veterinary hospital, including blaZ, mecA, norA, norC, tetM, tet38, ermA, and ermB, which confer resistance to various antibiotics such as penicillin, methicillin, tetracycline, and erythromycin.
Inter-species diversity and functional genomic analyses of closed genome assemblies of clinically isolated, megaplasmid-containing Enterococcus raffinosus Er676 and ATCC49464.
The study characterizes antimicrobial resistance genes in Enterococcus raffinosus strains Er676 and ATCC49464, identifying genes such as tetM, ant(9)-Ia, ant(6)-Ia, ermA, efrA, efrB, optrA, and fexA, which confer resistance to tetracyclines, aminoglycosides, macrolides, oxazolidinones, and phenicols.
Fecal antibiotic resistance genes were transferred through the distribution of soil-lettuce-snail food chain.
The study identified several antibiotic resistance genes (ARGs) such as aacA43, mel_1, vanRB, tetM, tnpA-2, sul1, sul2, ermF, and vatB that were transferred through the soil-lettuce-snail food chain. These genes conferred resistance to various antibiotics including aminoglycosides, tetracyclines, sulfonamides, MLSB, and vancomycin.
Prevalence and antibiotic resistance of Staphylococcus aureus associated with a college-aged cohort: life-style factors that contribute to nasal carriage.
The study identified several AMR genes in S. aureus isolates, including blaZ, mecA, tetM, dfrS1, ermA, ermC, msrA, and norA, which conferred resistance to penicillin, cefoxitin, tetracycline, trimethoprim, azithromycin, and ciprofloxacin.
Clostridium ramosum Bacteremia in an Immunocompetent Patient with SARS-CoV-2 Infection: A Case Report.
The study identifies two antimicrobial resistance genes, tetM and ermB, in the Clostridium ramosum strain WD-I2, explaining resistance to tetracycline and macrolides.
Antimicrobial resistance and virulence profiles of staphylococci isolated from clinical bovine mastitis.
The study identified several AMR genes including blaZ, mecA, tetK, tetM, ermC, and ermB in Staphylococcus aureus and coagulase-negative staphylococci isolated from bovine mastitis. These genes conferred resistance to penicillin, methicillin, tetracycline, and erythromycin.
Genomic Features of Antimicrobial Resistance in Staphylococcus pseudintermedius Isolated from Dogs with Pyoderma in Argentina and the United States: A Comparative Study.
The study identified various antimicrobial resistance genes and mutations in Staphylococcus pseudintermedius isolates from dogs in Argentina and the United States, highlighting differences in resistance profiles between the two regions.
Characterization of the pig lower respiratory tract antibiotic resistome.
The study characterizes the antibiotic resistome of the pig lower respiratory tract microbiome, identifying 372 ARGs, including tetracycline, aminoglycoside, and phenicol resistance genes, and highlights the role of MGEs in their dissemination.
Genomic and functional portrait of multidrug-resistant, hydrogen sulfide (H(2)S)-producing variants of Escherichia coli.
The study identified multidrug-resistant, hydrogen sulfide-producing variants of Escherichia coli from Bangladesh, highlighting the presence of various AMR genes such as bla TEM1B, bla CTX-M-55, bla CTX-M-65, bla CTX-M-123, aadA1, aadA2, aph (3')-Ia, aph (3'')-Ib, aph (6)-Id, tet(A), tet(M), sul3, sul2, dfrA12, mph(A), floR, cmlA1, qacL, and qnrS1.
Genetic characterization of MDR genomic elements carrying two aac(6')-aph(2") genes in feline-derived clinical Enterococcus faecalis isolate.
The study identified a multidrug-resistant E. faecalis isolate (ESC1) carrying a novel composite transposon with two aac(6')-aph(2") genes, along with several other resistance genes on plasmids, contributing to resistance against multiple antibiotics.
Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin.
The study identified the presence of the tetracycline resistance gene tetK in Mammaliicoccus sciuri isolates, which was associated with tetracycline resistance. The gene was found on small plasmids, suggesting a potential mechanism for horizontal gene transfer.
The effects of antibiotic use on the dynamics of the microbiome and resistome in pigs.
The study identified several antibiotic resistance genes (ARGs) in porcine fecal microbiota, including aacA-aphD, ermT, lnuB, strB, sul2, tetA, tetM, and blaTEM, which showed increased abundance in antibiotic-treated pigs compared to untreated pigs.
Antimicrobial Resistance of Erysipelothrix rhusiopathiae Strains Isolated from Geese to Antimicrobials Widely Used in Veterinary Medicine.
The study identified the tetM gene as a major determinant of tetracycline resistance and point mutations in the gyrA gene as a key factor in fluoroquinolone resistance in E. rhusiopathiae isolates from geese.
Application of CRISPR-Cas system in the diagnosis and therapy of ESKAPE infections.
The review discusses the application of CRISPR-Cas systems in diagnosing and treating ESKAPE infections, highlighting their potential in detecting and targeting drug-resistant pathogens.
Antimicrobial resistance and molecular typing of Staphylococcus aureus isolates from raw milk in Hunan Province.
The study identified multiple antimicrobial resistance genes in Staphylococcus aureus isolates from raw milk in Hunan Province, including femB, ermB, aacA-aphD, tetM, flor, and mecA, which conferred resistance to various antibiotics such as penicillin, erythromycin, gentamicin, doxycycline, florfenicol, and others.
Whole genome sequence-based analysis of Staphylococcus aureus isolated from bovine mastitis in Thuringia, Germany.
The study identified multiple AMR genes and mutations in Staphylococcus aureus isolates from bovine mastitis in Thuringia, Germany, including blaZ, blaI, blaR, blaPC, mecA, tetM, tetK, ermA, dfrG, dfrK, ant(6)-Ia, aac(6')-Ie-aph(2"), aadD1, ant(9)-Ia, ant(4')-Ia, aph(2")-Ih, gyrA_S84L, and parC_S80F/Y.
Molecular characterization of invasive Streptococcus pneumoniae clinical isolates from a tertiary children's hospital in eastern China.
The study identified multiple AMR genes in invasive S. pneumoniae isolates, including erm(B), mef(A), msr(D), tet(M), cat-TC, and blaTEM-116, which conferred resistance to erythromycin, tetracycline, chloramphenicol, and beta-lactam antibiotics. All isolates exhibited multidrug resistance.
Probiotics Modulate Host Immune Response and Interact with the Gut Microbiota: Shaping Their Composition and Mediating Antibiotic Resistance.
The study identifies tetracycline resistance genes (tetM, tetL) and a fluoroquinolone resistance gene (parC) in probiotic strains, highlighting the potential for probiotics to mediate antibiotic resistance.
Probiotics Modulate Host Immune Response and Interact with the Gut Microbiota: Shaping Their Composition and Mediating Antibiotic Resistance.
The study identifies tetracycline resistance genes (tetM, tetL) and a fluoroquinolone resistance gene (parC) in probiotic strains, highlighting the potential for probiotics to mediate antibiotic resistance.
Whole genome sequence-based characterization of virulence and antimicrobial resistance gene profiles of Staphylococcus aureus isolated from food poisoning incidents in eastern China.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from food poisoning incidents in Eastern China, including blaZ, aadD1, mecA, ermB, and tetM, which confer resistance to penicillin, gentamicin, methicillin, erythromycin, and tetracycline, respectively.
Characterization of a Tigecycline-, Linezolid- and Vancomycin-Resistant Clinical Enteroccoccus faecium Isolate, Carrying vanA and vanB Genes.
The study identifies the presence of vanA and vanB genes, along with poxtA, fexB, tet(M), and tet(L) in a multidrug-resistant Enterococcus faecium isolate, highlighting the coexistence of multiple resistance mechanisms.
Detection of tetracycline resistance genes and their diversity in Escherichia coli isolated from pig farm waste in Banten province, Indonesia.
The study identified several tetracycline resistance genes, including tetA, tetB, tetC, tetM, tetO, and tetX, in Escherichia coli isolated from pig farm waste in Banten province, Indonesia. tetX and tetO were the most prevalent genes, with high frequencies detected in both solid waste and wastewater samples.
Antimicrobial Susceptibility to 27 Drugs and the Molecular Mechanisms of Macrolide, Tetracycline, and Quinolone Resistance in Gemella sp.
The study identified ermB, mefE, and tetM as the primary genes responsible for macrolide, tetracycline, and quinolone resistance in Gemella sp. Additionally, specific mutations in gyrA were linked to levofloxacin resistance.
Tetracycline resistance in Listeria monocytogenes and L. innocua from wild black bears (Ursus americanus) in the United States is mediated by novel transposable elements.
The study identifies novel tetracycline resistance elements, including Tn 916.1039, Tn 5801.UAM, Tn 5801.551, and Tn 6000.205, in Listeria monocytogenes and L. innocua from wild black bears, highlighting the role of non-pathogenic Listeria species as reservoirs for antimicrobial resistance.
Clostridioides difficile from Fecally Contaminated Environmental Sources: Resistance and Genetic Relatedness from a Molecular Epidemiological Perspective.
The study identified multiple AMR genes in C. difficile isolates from environmental sources, including gyrA, gyrB, blaCDD-1, blaCDD-2, tet(M), tet(40), aph(3')-IIIa, ant(6)-la, sat-4, and ermB, which confer resistance to fluoroquinolones, beta-lactams, tetracyclines, aminoglycosides, and MLS B antibiotics.
Antimicrobial resistance and whole genome sequencing of novel sequence types of Enterococcus faecalis, Enterococcus faecium, and Enterococcus durans isolated from livestock.
The study identifies several antimicrobial resistance genes in Enterococcus species isolated from livestock in South Africa, highlighting the presence of multidrug-resistant strains and emphasizing the need for genomic surveillance to monitor the spread of antimicrobial resistance in food chain animals.
Synergistic effects of polymyxin and vancomycin combinations on carbapenem- and polymyxin-resistant Klebsiella pneumoniae and their molecular characteristics.
Significant increase in the prevalence of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus, particularly the USA300 variant ΨUSA300, in the Japanese community.
The study found a significant increase in the prevalence of PVL-positive MRSA, particularly the USA300 variant ΨUSA300, in the Japanese community. ΨUSA300 was associated with deep-seated SSTIs and showed distinct antimicrobial resistance profiles compared to USA300.
Distribution and association of antimicrobial resistance and virulence characteristics in Enterococcus spp. isolates from captive Asian elephants in China.
The study identified tet(M), erm(B), and cfr as the most prevalent antimicrobial resistance genes in Enterococcus spp. isolates from captive Asian elephants, highlighting their role in resistance to tetracycline, erythromycin, and chloramphenicol, respectively.
Antimicrobial Resistance Genes in Staphylococcus Species Isolated from Diabetic Foot Ulcers and Healthy Skin
The study identified various antimicrobial resistance genes in Staphylococcus species isolated from diabetic foot ulcers and healthy skin, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, macrolides, tetracyclines, fusidic acid, trimethoprim-sulfamethoxazole, fosfomycin, kanamycin, neomycin, and quaternary ammonium compounds.
Investigation of antimicrobial susceptibility and genetic diversity among Staphylococcus pseudintermedius isolated from dogs in Rio de Janeiro.
The study identified 21 resistance determinants in MRSP and MSSP strains of Staphylococcus pseudintermedius, including genes such as blaZ, sdrM, norA, fosB, ykkcd, sepA, aac(6')-aph(2''), dfrG, aph(3')-III, ant(6)-Ia, sat4, erm(B), aad(6), tet(M), cat(pC221), qacG, tet(K), and qacJ, which confer resistance to various antimicrobials.
Antibiotic Resistance Genes and Virulence Factors in Group B Streptococcus Isolates from Non-Pregnant Populations
The study identifies the tetracycline resistance gene tetM as the most common resistance gene in Streptococcus agalactiae isolates from non-pregnant populations, with a prevalence of 55%.
Molecular characteristics of Staphylococcus aureus strains isolated from subclinical mastitis of water buffaloes in Guangdong Province, China.
The study identified several AMR genes in S. aureus isolates from subclinical mastitis in water buffaloes, including tetM, msrB, blaZ, mecA, and fexA. These genes conferred resistance to tetracycline, erythromycin, penicillin, cefoxitin, and florfenicol, respectively.
Occurrence and temporal distribution of extended-spectrum β-lactamase-producing Escherichia coli in clams from the Central Adriatic, Italy.
The study identified several β-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV12, bla CMY-2, bla TEM-1B, bla TEM-106, and bla TEM-126, which confer resistance to various β-lactam antibiotics. Other resistance genes such as aac(6′)-Ib-cr, qnrS1, tet(A), tet(B), tet(M), aadA5, aadA2b, sul1, sul2, sul3, dfrA17, dfrA5, dfrA14, dfrA12, mph(A), cmlA1, catA2, aac(3)-IIa, aac(3)-IId, and lnu(F) were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates from clams in the Central Adriatic.
A novel invasive Streptococcus pyogenes variant sublineage derived through recombinational replacement of the emm12 genomic region.
The study identifies a novel sublineage of Streptococcus pyogenes (emm82/ST36) that emerged through recombinational replacement of the emm12 genomic region, exhibiting diverse resistance mechanisms including macrolide and tetracycline resistance.
Draft genome sequencing data of Enterococcus faecium BT22, a vancomycin-resistant opportunistic pathogen isolated from hospital effluents.
The study identified 12 antibiotic resistance genes and one virulence gene in strain BT22, including genes conferring resistance to aminoglycosides, macrolides, tetracyclines, and vancomycin.
Clostridium neonatale antimicrobial susceptibility, genetic resistance determinants, and genotyping: a multicentre spatiotemporal retrospective analysis.
The study identified several AMR genes in Clostridium neonatale, including erm(B), tet(O), tet(32), tet(M), bla TEM-116, bla CBP-1-like, and aph(3')-IIa, which confer resistance to clindamycin, tetracycline, cefotaxime, and gentamicin. These genes are associated with mobile genetic elements.
Antibiotic resistance, bacterial transmission and improved prediction of bacterial infection in patients with antibody deficiency.
The study identifies high levels of antibiotic resistance in respiratory tract bacteria from patients with antibody deficiency, particularly macrolide resistance genes erm(B) and mef(A), and highlights the role of commensal streptococci as reservoirs for resistance genes.
Molecular characterisation and antimicrobial resistance of Streptococcus agalactiae isolates from dairy farms in China.
The study identified tetracycline resistance genes tet(M), tet(O), and erythromycin resistance gene erm(B) in Streptococcus agalactiae isolates from dairy farms in China.
Antimicrobial Resistant Bacteria Monitoring in Raw Seafood Retailed: a Pilot Study Focused on Vibrio and Aeromonas.
The study identified tetracycline, sulfamethoxazole, and trimethoprim/sulfamethoxazole resistance genes (tetD, tetB, tetM, tetE, sul1, sul2, and dfrA) in Vibrio and Aeromonas isolates from raw seafood samples in Japan.
Persistence of Marine Bacterial Plasmid in the House Fly (Musca domestica): Marine-Derived Antimicrobial Resistance Genes Have a Chance of Invading the Human Environment.
The study shows that the marine bacterial plasmid pAQU1, carrying several antimicrobial resistance genes, can persist in the house fly intestine for up to 5 days, potentially facilitating the transmission of marine-derived antimicrobial resistance genes to the human environment.
Enterococcus species: insights into antimicrobial resistance and whole-genome features of isolates recovered from livestock and raw meat in Ghana.
The study identified various antimicrobial resistance genes in Enterococcus spp. isolated from livestock and raw meat in Ghana, including genes conferring resistance to erythromycin, tetracycline, chloramphenicol, and other antibiotics. Notable genes include aac(6')-Ii, aph(3')-III, ant(6)-Ia, erm(B), erm(T), msr(C), lsa(A), lsa(E), lnu(B), tet(L), tet(M), tet(S), dfrG, cat, pbp5, and ClpL.
Metagenomic identification of pathogens and antimicrobial-resistant genes in bacterial positive blood cultures by nanopore sequencing.
The study identified various antimicrobial resistance (AMR) genes in bacterial positive blood cultures using nanopore sequencing, demonstrating the effectiveness of this method in detecting resistance mechanisms and pathogens quickly.
Canine Staphylococcaceae circulating in a Kenyan animal shelter.
The study identified various AMR genes in Staphylococcaceae strains isolated from dogs in a Kenyan animal shelter, including tetracycline, beta-lactam, and aminoglycoside resistance genes.
Streptococcus suis Research Update: Serotype Prevalence and Antimicrobial Resistance Distribution in Swine Isolates Recovered in Spain from 2020 to 2022.
The study identified the prevalence of antimicrobial resistance genes in Streptococcus suis isolates from Spain, including tet(O), erm(B), lnu(B), lsa(E), tet(M), and mef(A/E). High resistance levels were observed for clindamycin, chlortetracycline, and sulfadimethoxine.
Probiotic-Induced Modulation of Microbiota Composition and Antibiotic Resistance Genes Load, an In Vitro Assessment.
The study found that probiotics significantly reduced the levels of tetM and tetO genes, as well as the blaTEM gene, in fecal cultures from both normal-weight and extremely obese individuals.
Exploring the Interplay of the CRISPR-CAS System with Antibiotic Resistance in Staphylococcus aureus: A Poultry Meat Study from Lahore, Pakistan.
The study identifies the presence of antibiotic resistance genes mecA, tetM, ermA, and gyrA in multidrug-resistant Staphylococcus aureus isolates from poultry meat, suggesting a link between the CRISPR-Cas system and antibiotic resistance.
Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis.
The study characterizes the resistome of Gram-positive bacteria causing keratitis, identifying several AMR genes and mutations associated with resistance to antibiotics such as macrolides, aminoglycosides, tetracyclines, and fluoroquinolones. Key findings include the prevalence of ermA, ermB, ermC, mphC, msrA, msrD, mecA, ant(9)-Ia, ant(4′)-Ib, aac(6′)-aph(2″), aph(3′)-III, fosB, tetK, tetM, dfrG, dfrC, and dfrE genes, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Genomic insights into ESBL-producing Escherichia coli isolated from non-human primates in the Peruvian Amazon.
The study identified three bla CTX-M variants (bla CTX-M-15, bla CTX-M-55, and bla CTX-M-65) and a broad resistome in ESBL-producing E. coli strains isolated from non-human primates in the Peruvian Amazon.
Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China.
The study identifies various antimicrobial resistance genes in Clostridioides difficile isolates from children, including those conferring resistance to aminoglycosides, macrolides, fluoroquinolones, glycopeptides, lincosamides, tetracyclines, and others. Notably, the pCD-METRO plasmid and vanA/B were not detected, indicating alternative resistance mechanisms.
Prevalence of virulence- and antibiotic resistance-associated genotypes and phenotypes in Staphylococcus aureus strains from the food sector compared to clinical and cow mastitis isolates.
The study identified various antibiotic resistance genes and mutations in Staphylococcus aureus strains from different sources, including beta-lactam resistance genes (blaZ, mecA), aminoglycoside resistance genes (ant(4')-Ia, aph(3')-Ia), tetracycline resistance genes (tetM, tetK), and the bleO gene for bleomycin resistance. Mutations in gyrA and grlA were also found to contribute to quinolone resistance.
Serotype, antibiotic susceptibility and whole-genome characterization of Streptococcus pneumoniae in all age groups living in Southwest China during 2018-2022.
The study identified several AMR genes in Streptococcus pneumoniae isolates from Southwest China, including msrD, mefA, ermB, tetM, and catTC, which confer resistance to erythromycin, tetracycline, and chloramphenicol. High levels of resistance to erythromycin (96.96%) and tetracycline (79.85%) were observed, along with significant multidrug resistance.
Macrolide and lincosamide resistance of Streptococcus agalactiae in pregnant women in Poland.
The study identifies the ermB, mefA, ermA, lnuB, lsaE, and tetM genes as key contributors to macrolide and lincosamide resistance in Streptococcus agalactiae isolates from pregnant women in Poland.
Clinical, microbiological, and molecular characterization of pediatric invasive infections by Streptococcus pyogenes in Spain in a context of global outbreak.
The study identified tetracycline resistance mediated by tetM, erythromycin and clindamycin resistance mediated by ermB, ermT, and mefA in Streptococcus pyogenes isolates from pediatric invasive infections in Spain.
Multidrug-resistant Enterococcus faecium strains enter the Norwegian marine environment through treated sewage.
The study identified multidrug-resistant Enterococcus faecium strains carrying resistance genes such as aac(6')-Ii, erm(B), erm(T), tet(L), tet(M), and msr(C), as well as mutations in gyrA and parC contributing to ciprofloxacin resistance.
Whole-genome sequencing-based antimicrobial resistance and shedding dynamics of Escherichia coli isolated from calves before and after antimicrobial group treatments.
The study identified several AMR genes and mutations in E. coli isolates from calves, including tetracycline resistance genes (Tet(A), Tet(B), Tet(C), Tet(M)), β-lactamases (TEM-1, TEM-35, OXA-1), florfenicol resistance gene FloR, and macrolide phosphotransferase Mph(B). Mutations in GyrA (D87N, D87Y, S83L) and ParC (S80I) were also associated with quinolone resistance.
Genetic Diversification and Resistome of Coagulase-Negative Staphylococci from Nostrils of Healthy Dogs and Dog-Owners in La Rioja, Spain.
The study identified various AMR genes including blaZ, mecA, erm(A), erm(C), erm(T), mph(C), msr(A), vga(A), lsaB, ant4′, aac6′-aph2″, tet(K), tet(M), dfrA, dfrG, catPC221, and mupA in CoNS isolates from healthy dogs and dog-owners. Additionally, a linezolid-resistant S. epidermidis isolate was found to have multiple amino acid substitutions in 50S ribosomal proteins L3 and L4.
Characterization of Gallibacterium anatis Isolated from Pathological Processes in Domestic Mammals and Birds in the Czech Republic.
The study identified several AMR genes in Gallibacterium anatis isolates from calves and hens, including aph(3"-Ib, aph(6)-Id, sul2, tet(B), tet(M), bla CARB, and bla ROB. Calf isolates showed a higher incidence of AMR genes compared to hen isolates.
Genomic analysis of Salmonella isolated from canal water in Bangkok, Thailand.
The study identified 35 AMR genes and 30 chromosomal-mediated gene mutations in Salmonella strains from Bangkok canal water, highlighting the presence of multidrug-resistant strains with resistance to various antimicrobial classes.
Molecular mechanisms of tigecycline-resistance among Enterobacterales.
The paper reviews the molecular mechanisms of tigecycline resistance in Enterobacterales, highlighting the roles of efflux pumps, tet genes, and other resistance mechanisms. It identifies several tigecycline resistance genes, including tet(X), tet(X1), tet(X2), tet(X3), tet(X4), tet(M), tet(A), tet(B), tet(Y), and others, along with their associated resistance profiles.
Streptococcus suis serotype 4: a population with the potential pathogenicity in humans and pigs.
The study identified multiple antibiotic resistance genes in Streptococcus suis serotype 4, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, oxazolidinones, and chloramphenicol. Prophages were identified as the primary vehicle for the dissemination of these resistance genes.
Genomic characterization of Staphylococcus aureus isolated from patients admitted to intensive care units of a tertiary care hospital: epidemiological risk of nasal carriage of virulent clone during admission.
The study identified several AMR genes in Staphylococcus aureus isolates from ICU patients, including aac(6')-aph(2''), ant(9)-Ia, erm(A), tet(M), qacB, and fosD, which confer resistance to various antibiotics.
Genomic insights into the diversity, virulence, and antimicrobial resistance of group B Streptococcus clinical isolates from Saudi Arabia.
The study identified several AMR genes including erm(B), erm(A), lsa(C), mef(A), tet(M), tet(O), aac(6')-aph(2''), ant(6)-Ia, aph(3')-III, and aadE in GBS isolates from Saudi Arabia, highlighting the prevalence of resistance to macrolides, lincosamides, tetracycline, and aminoglycosides.
Defining the phylogenetics and resistome of the major Clostridioides difficile ribotypes circulating in Australia.
The study identifies AMR genes such as ermB, tetM, aac(6')-Ib, sat4A, ant6-Ia, and aph3-III in Clostridioides difficile strains, particularly in RT014/020. Mutations in gyrA and gyrB contribute to fluoroquinolone resistance. AMR is uncommon, with limited evidence of clonal transmission.
Integrative and Conjugative Elements and Prophage DNA as Carriers of Resistance Genes in Erysipelothrix rhusiopathiae Strains from Domestic Geese in Poland.
The study identifies the presence of resistance genes erm47 and ermB in Erysipelothrix rhusiopathiae strains from domestic geese in Poland, along with other resistance genes such as tetM, lnuB, lsaE, ant(6)-Ia, and spw. It also highlights the role of integrative and conjugative elements (ICEs) and prophage DNA in the spread of these resistance genes.
Molecular detection of multidrug and methicillin resistance in Staphylococcus aureus isolated from wild pigeons (Columba livia) in South Africa.
The study identified multiple antibiotic resistance genes, including mecA, tetM, aac(6')-aph(2"), ermC, and blaZ, in Staphylococcus aureus isolates from wild pigeons in South Africa, highlighting the presence of multidrug-resistant and methicillin-resistant S. aureus in the environment.
Complete genome sequence of the linezolid-resistant clinical Enterococcus faecalis N23-3408 linked to a livestock lineage in Switzerland.
The linezolid-resistant E. faecalis N23-3408 harbors the optrA gene on a plasmid, along with other resistance genes including cat, erm(B), fexA, tet(L), and tet(M).
What's on a prophage: analysis of Salmonella spp. prophages identifies a diverse range of cargo with multiple virulence- and metabolism-associated functions.
The study identified several antimicrobial resistance genes (ARGs) carried by intact prophages in Salmonella spp., including acrB, mdtK, bacA, TEM-212, tet(M), and sul2, which confer resistance to various antibiotics.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
The study identifies multiple AMR genes and mutations in multidrug-resistant E. coli strains causing infections in dogs and cats, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla CMY-2, bla CMY-148, aac(6')-Ib-cr, qnrS1, qnrB6, aadA2, aadA5, aadA16, ant(3′′)-Ia, aph(3′)-Ia, aph(3′′)-Ib, aph(6)-Id, rmtB, floR, cmlA, catA, sul1, sul2, sul3, dfrA12, dfrA14, dfr17, dfrA27, tet(A), tet(B), tet(M), mph(A), erm(B), lnu(F), and arr-3, as well as the gyrA:p.S83L mutation.
The Genetic Landscape of Antimicrobial Resistance Genes in Enterococcus cecorum Broiler Isolates.
The study identified several antimicrobial resistance genes (ARGs) in Enterococcus cecorum isolates, including ant(6)-la, ermB, lsaE, tet(M), tet(L), and vanA, which are associated with resistance to aminoglycosides, macrolides, lincosamides, tetracyclines, and glycopeptides. Additionally, point mutations in GyrA, GyrB, ParC, and PBP2x were found to contribute to resistance against enrofloxacin and β-lactam antibiotics.
Molecular basis of the persistence of chloramphenicol resistance among Escherichia coli and Salmonella spp. from pigs, pork and humans in Thailand.
The study identifies catA and cmlA as the primary genes responsible for chloramphenicol resistance in E. coli and Salmonella isolates from Thailand, highlighting their persistence through co-selection and horizontal gene transfer.
Antimicrobial resistance, enterotoxin and biofilm production genes in Staphylococcus spp. isolated from facilities and fomites in veterinary hospital in the Caatinga biome.
The study identified several antimicrobial resistance genes including blaZ, mecA, tetM, tetL, and tetK in Staphylococcus spp. isolates from a veterinary hospital in the Caatinga biome. Additionally, the icaD gene associated with biofilm production was detected in one S. sciuri strain.
Characterization of resistance and virulence factors in livestock-associated methicillin-resistant Staphylococcus aureus.
The study identified several AMR genes including mecA, mecC, tetM, ermA, ermC, vanA, and vanC in livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates. These genes conferred resistance to various antibiotics such as penicillin, tetracycline, erythromycin, and vancomycin. Additionally, virulence factors like PVL, tsst-1, icaA, and icaB were prevalent in the isolates.
Genomic characterisation of Escherichia coli isolated from poultry at retail through Sink Surveillance in Dhaka, Bangladesh reveals high levels of multi-drug resistance.
The study identified multiple AMR genes in E. coli isolates from poultry in Bangladesh, including genes conferring resistance to various antibiotics such as tetracycline, ciprofloxacin, azithromycin, colistin, and others. High levels of multidrug resistance were observed, with specific genes like mcr1.1, bla CTX-M-65, and tet(A) playing significant roles.
The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.
The 2024 WHO Neisseria gonorrhoeae reference strains were characterized for their antimicrobial resistance profiles, including mutations in genes such as GyrA, ParC, 23S rRNA, rpsJ, penA, mtrR, and mtrD, as well as the presence of beta-lactamase genes like blaTEM-1 and blaTEM-135, and tetracycline resistance gene tet(M).
Evaluation of Antimicrobial Resistancein Clinical Isolates of Enterococcus spp. Obtained from Hospital Patients in Latvia.
The study identifies several AMR genes and mutations in Enterococcus isolates, including vanB for vancomycin resistance, lsaA, lsaE, lnuB for lincosamide resistance, tetM and tetL for tetracycline resistance, aac6'-Ii, aac6'-aph2'', aph3'-III, and ant6-Ia for aminoglycoside resistance, msrC, ermB, and ermT for macrolide resistance, and mutations in gyrA, parC, pbp5, and 23S rRNA for fluoroquinolone, penicillin, and linezolid resistance.
Genome analysis of multidrug resistant Enterococcus faecium and Enterococcus faecalis circulating among hospitalized patients in uMgungundlovu District, KwaZulu-Natal, South Africa.
The study identified multiple AMR genes including VanC-1, VanG, Vex2, Vex3, emeA, Isa, ermB, TetM, fosB, ParC, ParE, gyrA, gyrB, MATE, MFS, and pmrA in multidrug-resistant Enterococcus faecium and Enterococcus faecalis. These genes conferred resistance to various antibiotics such as vancomycin, tetracycline, erythromycin, clindamycin, ciprofloxacin, and moxifloxacin.
Emergence of novel methicillin resistant Staphylococcus pseudintermedius lineages revealed by whole genome sequencing of isolates from companion animals and humans in Scotland.
The study identified novel methicillin-resistant Staphylococcus pseudintermedius (MRSP) lineages, including ST726 and ST551, and characterized antimicrobial resistance genes such as mecA, blaZ, tetK, and mupA. It also noted a high prevalence of multidrug resistance (MDR) among MRSP isolates.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
Characterization of group A streptococci causing invasive diseases in Sri Lanka.
The study identified erythromycin resistance mediated by erm(B) and mef(A) genes, and tetracycline resistance mediated by the tet(M) gene in group A streptococci isolates from Sri Lanka.
Occurrence of Enterococci in the Process of Artisanal Cheesemaking and Their Antimicrobial Resistance.
The study identified the presence of vanA and tetM genes in Enterococcus isolates, indicating resistance to vancomycin and tetracycline, respectively. These genes were found in various Enterococcus species, highlighting the potential public health concerns related to antimicrobial resistance in artisanal cheesemaking processes.
Emergence of Extensively Drug-Resistant Neisseria gonorrhoeae, France, 2023.
Genomic diversity, antibiotic resistance, and virulence in South African Enterococcus faecalis and Enterococcus lactis isolates.
The study identifies several antibiotic resistance genes in South African Enterococcus faecalis and Enterococcus lactis isolates, including dfrE, vanW, vanT, efrA, tet(M), AAC(6')-Ii, msrC, and vanY, which confer resistance to trimethoprim, glycopeptides, tetracycline, macrolides, and aminoglycosides.
Antimicrobial Resistance in Pathogenic Staphylococci Causing Mastitis and Skin, Ear and Vaginal Infections in Animals
The study identified tetracycline resistance genes tetK and tetM in staphylococci isolated from animals in Uganda, with tetK being the most prevalent.
Methicillin-resistant Staphylococcus aureus outbreak in a Dutch equine referral clinic.
The study identified multiple AMR genes including aac(6')-Ie/aph(2'')-Ia, tetM, dfrK, ermC, and dfrC in MRSA isolates from horses, staff, and the environment. Additionally, mutations in folP, gyrA, and rpoB were found to confer resistance to sulfonamides, fluoroquinolones, and rifampicin respectively.
Biofilm enhanced the mitigations of antibiotics and resistome in sulfadiazine and trimethoprim co-contaminated soils.
The study identifies several AMR genes, including aadA7, aac(6')-II, aac(3)-iid, aadD, tetA, tetM, tetX, and sul2, in Arthrobacter sp. D2, which are involved in resistance to aminoglycosides, tetracyclines, and sulfonamides. These genes were experimentally validated using high-throughput qPCR analysis.
A nisin-inducible chromosomal gene expression system based on ICE Tn5253 of Streptococcus pneumoniae, transferable among streptococci and enterococci.
The study presents a nisin-inducible chromosomal gene expression system based on ICE Tn5253 of Streptococcus pneumoniae, which allows for the controlled expression of genes in various streptococci and enterococci. The system includes the nisRK regulatory system and the PnisA promoter, enabling inducible gene expression. The system was validated through cloning, transformation, and expression of the emm6.1::ha1 fusion gene, demonstrating successful integration and expression in multiple bacterial species.
Antimicrobial Resistance in Coagulase-Negative Staphylococci: Resistome, Mobiloome, and Relatedness
The study identifies multiple AMR genes and mutations in CoNS isolates from various hosts, highlighting the spread of multidrug resistance and the role of mobile genetic elements in the dissemination of resistance traits.
Extended-spectrum beta-lactamase (ESBL)- and non-ESBL producing Escherichia coli surveillance in surface water sources in Edo State, Nigeria: a public health concern.
The study identified ESBL genes bla TEM, bla CTX-M-1, and bla CTX-M-15, as well as resistance genes tetM, sul1, sul2, and qnrA in ESBL and non-ESBL-producing E. coli isolates from surface water in Edo State, Nigeria.
Antibiotic resistance, virulence genes, and phylogenetic groups of bacteria isolated from wild passerine birds in Iran.
The study identified tetracycline resistance genes (tet(A), tet(B), tet(M), tet(L)) and the blaTEM gene associated with ampicillin resistance in bacteria isolated from wild passerine birds in Iran.
Molecular characterization, virulence and antimicrobial and biocidal susceptibility of selected bacteria isolated from the cloaca of nestling ospreys (Pandion haliaetus) from Mono Lake, California, USA.
The study identified several AMR genes and mutations in bacteria isolated from the cloaca of nestling ospreys, including bla CTX-M-55, bla EC, tet (A), floR, sul3, dfrA14, aac(3)-IIa, ampC, fosA5, sal (A), blaZ, tet (M), and pbp5. Mutations in gyrA, parC, parE, ompK36, ompK37, rpoB, and pbp5 were also detected, contributing to resistance against various antibiotics.
Group B Streptococcus Infections in Non-Pregnant Adults, Italy, 2015-2019.
The study identified the erm(B) gene as a major contributor to macrolide resistance, tet(M) and tet(O) genes as primary determinants of tetracycline resistance, and noted a significant increase in resistance to erythromycin and clindamycin among Group B Streptococcus isolates in Italy.
The gut microbiota of wild birds undergoing rehabilitation as a reservoir of multidrug-resistant enterococci in a metropolitan area in Brazil.
The study identified multiple antimicrobial resistance genes in enterococci isolated from wild birds, including genes conferring resistance to aminoglycosides, erythromycin, tetracycline, and streptogramins.
The role of TiO(2) and gC(3)N(4) bimetallic catalysts in boosting antibiotic resistance gene removal through photocatalyst assisted peroxone process.
The study identifies the effectiveness of photocatalyst-assisted peroxone process in removing antibiotic resistance genes such as blaTEM, ermB, qnrS, and tetM.
Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome.
The study found that doxy-PEP use over 6 months significantly increased the proportion and expression of tetracycline resistance genes in the gut microbiome, with no significant changes in other antibiotic resistance gene classes.
Safety assessment of enterocin-producing Enterococcus strains isolated from sheep and goat colostrum.
The study identified antibiotic resistance genes aph(3')-IIIa, tetM, and tetL in certain Enterococcus strains, indicating resistance to gentamicin and tetracycline. However, most strains showed susceptibility to clinically significant antibiotics.
Characterization of Staphylococcus aureus isolated from milk samples for their virulence, biofilm, and antimicrobial resistance.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from milk samples, including aphA, blaZ, addE1, erm(B), mecA, tetM, icaA, and icaD. These genes were associated with resistance to various antibiotics such as tylosin, penicillin, streptomycin, erythromycin, methicillin, tetracycline, and biofilm formation.
An antimicrobial resistance gene situationer in the backyard swine industry of a Philippine City.
The study identified the presence of antimicrobial resistance genes (ARGs) in swine feces from backyard farms in Davao City, Philippines, including bla TEM, ermB, qnrS, and tetM, which are associated with resistance to beta-lactams, macrolides, fluoroquinolones, and tetracyclines, respectively.
Genomic evaluation of the probiotic and pathogenic features of Enterococcus faecalis from human breast milk and comparison with the isolates from animal milk and clinical specimens.
The study identified antibiotic resistance genes lsaA, tetM, and ermB in Enterococcus faecalis isolates from human breast milk, with fewer resistance genes compared to clinical isolates. Mutations in gyrA and parC were observed in clinical isolates, contributing to quinolone resistance.
Evaluation of the QIAstat-Dx BCID GN and GPF kits for direct identification and antimicrobial resistance prediction from blood culture bottles.
The QIAstat-Dx BCID GN and GPF kits showed high accuracy in detecting AMR genes such as blaZ, mecA, ermC, aac(6')-lb, ctx-m, ampC, shv, tem, tetM, and aac(6')/aph(2") in various bacteria, correlating well with phenotypic resistance results.
Molecular characterization of the tet (M)-carrying transposon Tn7124 and plasmids in Escherichia coli isolates recovered from swine.
The study identifies the tet(M)-carrying transposon Tn7124 and plasmids pTA2 and pTA7 in E. coli isolates from swine, highlighting the presence of multiple antibiotic resistance genes such as tet(M), tet(A), floR, aadA1, cmlA1, aadA2, sul3, qnrS1, bleO, and oqxAB.
Escherichia coli from six European countries reveals differences in profile and distribution of critical antimicrobial resistance determinants within One Health compartments, 2013 to 2020.
The study identified various AMR genes in E. coli isolates from different sources in six European countries, highlighting differences in resistance profiles and the prevalence of specific resistance mechanisms such as beta-lactamases, quinolone resistance genes, and tetracycline resistance genes.
Data-Driven Approaches in Antimicrobial Resistance: Machine Learning Solutions.
This study uses unsupervised machine learning to identify patterns in AMR genes, linking gene length and resistance class to resistance mechanisms. Key AMR genes identified include sul1, sul2, cat, blaTEM, vanA, aac(6')-Ib, aph(3')-IIIa, tet(M), and tet(O).
Characterization of an Enterococcus sp. SMC-9 strain isolated from bile of a patient with cholangitis.
The study identified the tetracycline resistance gene tet(M) in Enterococcus sp. SMC-9, which explains its high tetracycline minimum inhibitory concentration (>16 μg/mL).
Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms.
The study identified two quinoxaline derivatives, compounds 25 and 31, which exhibit significant antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE) strains, with MIC values ranging from 0.25 to 1 mg/L.
Antibiotic Resistance and Serotypes Distribution in Streptococcus agalactiae Bulgarian Clinical Isolates During the Years of 2021-2024.
The study identified several AMR genes associated with macrolide, lincosamide, and tetracycline resistance in Streptococcus agalactiae isolates from Bulgaria. These include ermB, ermA/TR, ermC, mefA, mefE, msrD, lnuB, lsaC, lsaE, tetM, and tetO. High resistance rates to macrolides (60.3%) and tetracyclines (89.1%) were observed.
The healthy human gut can take it all: vancomycin-variable, linezolid-resistant strains and specific bacteriocin-species interplay in Enterococcus spp.
The study identifies linezolid resistance genes optrA and poxtA in Enterococcus faecium and Enterococcus thailandicus isolates, along with a vancomycin-variable E. faecium strain. It also reveals the increasing prevalence of E. lactis in the healthy human gut and the complex interplay of bacteriocin gene profiles among Enterococcus species.
Antibiotic susceptibility testing and molecular characterization based on whole-genome sequencing of Streptococcus pneumoniae isolates from pediatric infections at the National Regional Medical Center of Southwest China during the COVID-19 pandemic.
The study identified several AMR genes in Streptococcus pneumoniae isolates, including tet(M), erm(B), msr(D), and mef(A), which confer resistance to tetracycline, erythromycin, and macrolides. These findings highlight the genetic basis of antibiotic resistance in pneumococcal isolates during the post-pandemic period in Southwest China.
Prediction of antimicrobial susceptibility of pneumococci based on whole-genome sequencing data: a direct comparison of two genomic tools to conventional antimicrobial susceptibility testing.
The study evaluated the performance of two genomic tools, Pathogenwatch and AREScloud, for predicting antimicrobial susceptibility of pneumococci. It identified the presence of the ermB gene associated with erythromycin resistance and the tetM gene linked to tetracycline resistance.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Screening and Genomic Profiling of Antimicrobial Bacteria Sourced from Poultry Slaughterhouse Effluents: Bacteriocin Production and Safety Evaluation.
The study identified several bacteriocin gene clusters, including a novel class IId bacteriocin, lactococcin P1A (LcnP1A), in L. lactis SWD9. Additionally, various bacteriocins such as enterocin A, enterocin B, and garvieacin Q were characterized in different bacterial isolates.
Plasmidome of Salmonella enterica serovar Infantis recovered from surface waters in a major agricultural region for leafy greens in California.
The study identified tetracycline resistance genes, including tetB, tetR, tetC, acrAB, and robA, in the IncI plasmid pRM18148 of Salmonella enterica serovar Infantis strains isolated from surface waters in California.
Proximity-Ligation Metagenomic Sequence Analysis Reveals That the Antibiotic Resistome Makes Significant Transitions During Municipal Wastewater Treatment.
The study reveals significant transitions in the antibiotic resistome during municipal wastewater treatment, highlighting the presence of various ARGs in untreated wastewater and their reduced abundance in treated samples. Notably, certain ARGs like blaOXA, mef(A), and msr(D) were prevalent in untreated wastewater, while others like aph(3")-Ib, aph(6)-Id, mef(C), mph(A), and mph(G) were more prominent in activated sludge samples.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
The presence of antibiotic-resistant bacteria at four Norwegian wastewater treatment plants: seasonal and wastewater-source effects.
The study identified the presence of resistance genes ermB, tetA, and tetM in wastewater treatment plants in Norway, highlighting their persistence in effluent and the need for advanced treatment processes to mitigate their environmental spread.
Re-visiting the potential impact of doxycycline post-exposure prophylaxis (doxy-PEP) on the selection of doxycycline resistance in Neisseria commensals.
The study identifies mutations in MtrR (A46T), rpsJ (V57M), and rplX (A14T) associated with doxycycline resistance in Neisseria commensals, as well as the presence of the tetM gene in high-level resistant isolates.
Antibiotic exposure enriches streptococci carrying resistance genes in periodontitis plaque biofilms.
The study identifies the tetracycline resistance gene tetM in Streptococcus spp. as a major contributor to tetracycline resistance in periodontitis plaque biofilms.
Genetic analysis reveals the genetic diversity and zoonotic potential of Streptococcus dysgalactiae isolates from sheep.
The study identified tet(M), tet(O), and erm(B) as the primary AMR genes in S. dysgalactiae isolates from sheep, contributing to resistance against doxycycline and erythromycin.
Cockroaches as Reservoirs, Vectors, and Potential Sentinels of Multidrug-Resistant Bacteria in Ugandan Communities: A Retrospective Analysis.
The study identified tetracycline and sulfonamide resistance genes (tetA, sul1, sul2) in Escherichia coli and tetracycline resistance genes (tetM, tetL) in Enterococcus spp. from cockroaches in Ugandan communities.
Clostridioides difficile recovered from hospital patients, livestock and dogs in Nigeria share near-identical genome sequences.
The study identified several AMR genes and mutations in C. difficile isolates from Nigeria, including erm(B) for clindamycin resistance, tet(M) for tetracycline resistance, cfr(B) for linezolid resistance, and erm(A) for MLSB resistance. Additionally, gyrA-Thr82Ile mutation was found to confer fluoroquinolone resistance.
Colonization of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci and its associated factors in cancer patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.
The study found a significant prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) colonization among cancer patients, highlighting the need for improved antibiotic stewardship and early detection strategies.
Prevalence and genetic characteristics of Campylobacter jejuni from laying-hens in Hubei Province, China.
The study identified multiple antibiotic resistance genes in Campylobacter jejuni isolates from laying-hens in Hubei Province, China, including blaOXA, tet(O), tet(M), tet(W), cmeR, and gyrA (T86I). High resistance rates were observed against ceftriaxone, enrofloxacin, doxycycline, and other antibiotics.
Relationship Between CRISPR-Cas Systems and Acquisition of Tetracycline Resistance in Non-Clinical Enterococcus Populations in Bulgaria.
The study identified tetM, tetS, tetO, and tetT genes as the primary tetracycline resistance genes in non-clinical Enterococcus populations in Bulgaria. These genes were found in various Enterococcus species, with tetM being the most prevalent. The presence of these genes was associated with the Tn916 transposon, indicating horizontal gene transfer mechanisms.
Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.
This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.
Characteristic profiles of molecular types, antibiotic resistance, antibiotic resistance genes, and virulence genes of Staphylococcus aureus isolates from caprine mastitis in China.
The study identified several AMR genes in S. aureus isolates from caprine mastitis in China, including blaZ, mecA, tetK, tetM, ermB, lnu(B), aacA-aphD, and gyrA, which confer resistance to various antibiotics such as penicillin, oxacillin, tetracycline, erythromycin, lincomycin, gentamicin, amikacin, and fluoroquinolones.
Fecal carriage and molecular characterization of carbapenem-resistant Enterobacteriaceae from hospitalized children in a tertiary hospital of Shandong, China.
The study identified bla NDM-1, bla NDM-5, and bla OXA-1 as the most prevalent carbapenemase genes in CRE isolates from hospitalized children in Shandong, China. Additional resistance genes such as bla CTX-M-55, bla CTX-M-15, sul 1, tet A, and mcr-1.26 were also characterized.
Investigation of ceftriaxone-resistant Neisseria gonorrhoeae detected in Scotland, 2018-2024.
The study identifies several AMR genes and mutations associated with ceftriaxone-resistant Neisseria gonorrhoeae in Scotland, including the mosaic penA-60.001 allele, gyrA and parC mutations, rpsJ V57M polymorphism, tetM, and the 23S rDNA A2059G mutation.
Genotypic profile of Staphylococcus spp., Enterococcus spp., and E. coli colonizing dogs, surgeons, and environment during the intraoperative period: a cross-sectional study in a veterinary teaching hospital in Brazil.
The study identified resistance genes blaZ, mecA, tet(M), and aacA-aphD in Staphylococcus spp. and Enterococcus spp. isolates, indicating high rates of methicillin-resistant Staphylococcus spp. and tetracycline-resistant Enterococcus spp. in a veterinary teaching hospital setting.
Microplastics enhance the prevalence of antibiotic resistance genes in mariculture sediments by enriching host bacteria and promoting horizontal gene transfer.
Microplastics enhance the prevalence of antibiotic resistance genes in mariculture sediments by enriching host bacteria and promoting horizontal gene transfer.
Genetic compatibility and ecological connectivity drive the dissemination of antibiotic resistance genes.
The study identifies and characterizes various antibiotic resistance genes (ARGs) involved in horizontal gene transfer, highlighting the role of genetic compatibility and ecological connectivity in the dissemination of these genes.
Predomination of hypervirulent ST283 and genetic diversity of levofloxacin resistance in multidrug-resistant, hypervirulent Streptococcus agalactiae in Thailand.
The study identified multiple AMR genes and mutations associated with tetracycline, erythromycin, clindamycin, and levofloxacin resistance in multidrug-resistant, hypervirulent Streptococcus agalactiae isolates in Thailand, highlighting the predominance of hypervirulent ST283 and the emergence of MDR-GBS.
Effect of Sub-Inhibitory Concentrations of Quaternary Ammonium Compounds and Heavy Metals on Antibiotic Resistance and Expression of Virulence Factors Among Staphylococcus spp. from Dairy Products.
Sub-inhibitory concentrations of benzalkonium chloride and cadmium chloride induce the overexpression of antibiotic resistance genes such as bla Z, erm B, mec A, tet K, and tet M in Staphylococcus isolates from dairy products, leading to increased antibiotic resistance.
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.
High-Risk VREfm Clones and Resistance Determinants in a Thai Hospital.
The study identified the vanA gene as the primary determinant of vancomycin resistance in all 29 VREfm isolates. Additional resistance genes such as aac(6')-Ii, ant(6')-Ia, erm(B), msr(C), tet(L), tet(M), aph(3')-III, aph(2'')-Ia, and inu(B) were also characterized, contributing to resistance against a variety of antibiotics.
Antimicrobial Resistance in Livestock and Its Impact on Public Health
The study highlights the role of livestock environments as reservoirs for antimicrobial resistance genes, identifying blaCTX-M-1, tetA, qnrS, and sul2 as key contributors to resistance in Escherichia coli, Salmonella spp., and Staphylococcus spp.
Comparative efficacy of levofloxacin, azithromycin, and doxycycline prophylaxis and treatment in an experimental Ureaplasma murine lung infection model.
The study identified the tetM gene as responsible for doxycycline resistance in Ureaplasma urealyticum ATCC 33175.
Inhibitory effects of benzyl isothiocyanate on widespread mcr-1-harbouring IncX4 plasmid transfer.
The study characterizes the presence of mcr-1.1, mcr-3.5, blaCTX-M-55, and tet(X4) genes in clinical isolates of Enterobacterales from Thailand, highlighting their role in multidrug resistance and the potential for horizontal gene transfer.
Salad Vegetables as a Reservoir of Antimicrobial-Resistant Enterococcus: Exploring Diversity, Resistome, Virulence, and Plasmid Dynamics.
The study identified vancomycin resistance genes (vanC, vanXY-C2) in a vancomycin-susceptible E. faecalis isolate, along with optrA, tetM, ermB, lsa(A), msr(C), and ant(6)-Ia genes in Enterococcus isolates, highlighting the presence of multidrug-resistant strains in salad vegetables.
Prevalence, virulence factors, and antibiotic resistance of Staphylococcus aureus in seafood products.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolated from seafood products, including blaZ, mecA, tetM, and ermA. These genes were associated with resistance to penicillin G, ampicillin, tetracycline, and erythromycin, respectively.
Isolation, Antimicrobial Susceptibility, and Genotypes of Three Pasteurellaeae Species Prevalent on Pig Farms in China Between 2021 and 2023.
The study identified 18 antimicrobial resistance genes in three Pasteurellaeae species, including tetracycline, beta-lactam, sulfonamide, aminoglycoside, and macrolide resistance genes. High frequencies of tet(L), tet(M), tet(A), blaTEM, sul2, aph(3')-Ia, dfrA12, qnrS1, strA, sul3, and mef(B) were observed.
Genome-Based Molecular Diversity of Extended-Spectrum β-Lactamase-Producing Escherichia coli From Pigeons in China.
The study identifies multiple extended-spectrum β-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla OXA, bla LAP, and bla CMY, as well as other antibiotic resistance genes such as mcr-1, mcr-1.1, tet(X4), aadA1, aadA2, aph(6)-Id, aph(3")-Ib, aph(3')-Ia, aph(3')-IIa, aac(3)-IVa, aph(4)-Ia, tet(A), tet(M), sul2, sul3, dfrA14, qnrS1, arr-2, fosA3, cmlA5, floR, mph(A), and lnu(F) in ESBL-producing E. coli isolates from pigeons in China.
Wild Birds as Drivers of Salmonella Braenderup and Multidrug Resistant Bacteria in Wetlands of Northern Italy.
The study identifies several AMR genes in bacterial isolates from wild aquatic birds in Northern Italy, including beta-lactamases (blaTEM, blaCMY-1, blaCMY-2, blaNDM, blaKPC), colistin resistance genes (mcr-2, mcr-3, mcr-4), tetracycline resistance genes (tetA, tetB, tetC, tetL, tetM, tetK), macrolide resistance genes (ermB, vatD, vgA, msrC), vancomycin resistance genes (vanC1, vanC2, vanM, vanG), sulfonamide resistance genes (sul1, sul2, sul3), aminoglycoside resistance genes (aac(3), aac(6')-Ib, aph(3')-Ia, armA, rmtB, rmtC, rmtF), and nitrofurantoin resistance genes (nfsA, nfsB).
Phylogenomic associations among methicillin-resistant Staphylococcus aureus isolates derived from pets, dairies, and humans.
The study identified several AMR genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates from pets, dairies, and humans, including mecA, tet(M), tet(K), erm(C), erm(A), mph(C), msr(A), blaR1, blaZ, blaI_of_Z, blaPC1, vga(A), fosB-Saur, sat4, bleO, ant(9)-Ia, aph(2'')-Ih, aph(3')-IIIa, and ant(4')-Ia. These genes confer resistance to various antibiotics such as methicillin, tetracycline, erythromycin, macrolides, lincomycin, fosfomycin, streptothricin, bleomycin, spectinomycin, amikacin, gentamicin, kanamycin, tobramycin, and others.
Changing patterns and biological features of community-acquired Clostridioides difficile infection in Southwest China: 7 years of surveillance data.
The study identified ermA and tetM as genes conferring resistance to erythromycin and tetracycline, respectively, in C. difficile strains. These findings were supported by antibiotic resistance testing.
Changing patterns and biological features of community-acquired Clostridioides difficile infection in Southwest China: 7 years of surveillance data.
The study identified ermA and tetM as genes conferring resistance to erythromycin and tetracycline, respectively, in C. difficile strains. These findings were supported by antibiotic resistance testing.
Antimicrobial susceptibility and genetic mechanisms of resistance of Ureaplasma isolates in North America between 2012 and 2023.
The study identified mutations in 23S rRNA, rplD, parC, gyrB, and parE genes associated with erythromycin, tetracycline, and levofloxacin resistance in Ureaplasma isolates. The tet(M) gene was detected in tetracycline-resistant isolates, and specific mutations in parC and gyrB were linked to fluoroquinolone resistance.
Human milk oligosaccharide metabolism and antibiotic resistance in early gut colonizers: insights from bifidobacteria and lactobacilli in the maternal-infant microbiome.
The study investigated the metabolism of human milk oligosaccharides (HMOs) by bifidobacteria and lactobacilli isolated from human milk and mother-infant fecal samples, along with their antibiotic resistance profiles. Bifidobacterium bifidum showed the highest HMO degradation capability and was the most antibiotic-susceptible species, whereas Bifidobacterium animalis subsp. lactis was resistant to most tested antibiotics.
Differences in virulence and drug resistance between Clostridioides difficile ST37 and ST1 isolates.
ST37 isolates exhibited higher resistance to chloramphenicol and tetracycline compared to ST1 isolates, with the presence of catQ and tetM genes in ST37 but not in ST1. ST1 isolates showed higher resistance to rifaximin, and the R505K mutation in rpoB was detected in rifaximin-resistant ST37 isolates.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
Population structure, antibiotic resistance and molecular characteristics of Streptococcus pneumoniae causing invasive disease in Hubei, China.
The study identified high prevalence of ermB and tetM genes in Streptococcus pneumoniae isolates, which are associated with macrolide and tetracycline resistance, respectively. ST271 strains showed higher resistance rates to several antibiotics compared to non-ST271 strains.
Genomic profiling of Streptococcus agalactiae (Group B Streptococcus) isolates from pregnant women in northeastern Mexico: clonal complexes, virulence factors, and antibiotic resistance.
The study identified the presence of mreA and tetM genes in all 51 S. agalactiae isolates, indicating widespread macrolide and tetracycline resistance. The mreA gene was found in 100% of isolates, while tetM was present in 60.1% of isolates.
The characteristics of methicillin-resistant Staphylococcus aureus co-infection in COVID-19 pneumonia.
The study identified several antimicrobial resistance genes in MRSA isolates from patients with COVID-19 pneumonia and MRSA pneumonia without COVID-19, including aac(6')-aph(2''), aph(2'')-Ia, aph(3')-III, aadD, ermA, ermB, ermC, tetM, tetK, mupA, and tst. No significant differences in antimicrobial resistance genes were observed between the two groups.
Genomic characterization of vancomycin-resistant enterococci in Norwegian poultry.
The study identified vanA and narAB genes on pVEF-like plasmids in vancomycin-resistant Enterococcus faecium and E. hirae isolates from Norwegian poultry, along with additional resistance genes such as ermB, tetM, and aac(6')-Ii.
Rabbit carcasses as important vectors of multidrug-resistant Enterococcus faecalis, but not E. faecium: prevalence and molecular characterization from a study in Poland.
The study identified multiple AMR genes in Enterococcus faecalis isolates from rabbit carcasses, including aac(6')-Ie-aph(2")-Ia, ant(6)-Ia, aph(3')-IIIa, ermB, tetM, and tetL, which were consistent with the observed phenotypic resistance patterns.
Comprehensive analysis of Enterococcus spp. from two European healthy infant cohorts shows stable genomic traits including antimicrobial resistance (AMR).
The study identified a range of antimicrobial resistance genes in Enterococcus spp. from two European infant cohorts, including aac(6')-aph(2"), vanC, and tet(M). These genes were associated with resistance to gentamicin, vancomycin, and tetracycline, respectively.
Comprehensive analysis of Enterococcus spp. from two European healthy infant cohorts shows stable genomic traits including antimicrobial resistance (AMR).
The study identified a range of antimicrobial resistance genes in Enterococcus spp. from two European infant cohorts, including aac(6')-aph(2"), vanC, and tet(M). These genes were associated with resistance to gentamicin, vancomycin, and tetracycline, respectively.
Occurrence and Drivers of Antibiotic Resistance Genes Carried by Bacteriophages in Soils Following Different Fertilization Treatments.
The study identified 19 pARG subtypes in soils with different fertilization treatments, highlighting the impact of organic fertilizers on the diversity and abundance of antibiotic resistance genes carried by bacteriophages.
The impact of green spaces, urban settings, seasonal changes, and pollutants on dissemination of antimicrobial genes in air.
The study identified several antimicrobial resistance genes (ARGs) in airborne samples, including blaTEM, mecA, aac(6')-Ib, ermB, ermC, tetM, tetW, sul1, and sul3. It found that the relative abundance of these ARGs varied with vegetation coverage, seasons, and environmental factors. High vegetation areas showed slightly lower ARG abundance compared to urban heat islands and low/no vegetation areas. The study highlights the potential of planting non-allergenic vegetation to reduce airborne ARG dissemination.
Characteristics of the integration sites and module structures of the Tn916 and its family.
The study identifies Tn916 and its family members, highlighting the presence of tetracycline resistance gene tetM and vancomycin resistance genes in various bacterial species.
Prevalence and antimicrobial resistance of Salmonella enterica isolated from cattle farms in Inner Mongolia.
The study identified several AMR genes in Salmonella enterica isolates from Inner Mongolia, including bla TEM-1, cmlA, tetA, tetB, tetM, aadA2, aph(3')-IIa, aacC4, aac(3)-IIa, sul1, sul3, oqxA, and oqxB, which confer resistance to beta-lactams, chloramphenicol, tetracyclines, aminoglycosides, sulfonamides, and quinolones.
Phenotypic and genotypic antimicrobial resistance profiles of clinical Clostridioides difficile isolates collected from private and public health settings in South Africa.
The study identified a PnimB promoter mutation associated with reduced metronidazole susceptibility in ST1 strains, a Thr82Ile mutation in gyrA linked to fluoroquinolone resistance, and various efflux pump and resistance genes such as qacG, aac(6')-Ie-aph(2'')-Ia, ermB, tetM, and CDD-1/CDD-2. High multidrug resistance (MDR) was observed in ST1 and ST37 strains.
Application of MALDI-TOF MS and FT-IR spectroscopy in identification and antibiotic resistance profiling of lactic acid bacteria.
The study demonstrates the correlation between FT-IR spectral profiles and antibiotic resistance in lactic acid bacteria, highlighting the utility of these techniques for rapid resistance detection.
Molecular and genomic insights into multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa causing burn wound infections in Bangladesh.
The study identified multiple beta-lactamase genes, including blaNDM-1, blaVIM-2, blaPER-1, blaCTX-M, blaOXA-1, and blaOXA-48, as well as efflux pump genes like mexA, mexC, and mexE, contributing to multidrug resistance in P. aeruginosa isolates from burn wound infections in Bangladesh.
Genomic surveillance of invasive Streptococcus pneumoniae strains in south Tunisia during 2012-2022.
The study identified the resistance genes erm B and tet M as the most prevalent in invasive Streptococcus pneumoniae isolates in south Tunisia, conferring resistance to erythromycin and tetracycline, respectively.
Genomic analysis and pneumococcal population dynamics across PCV implementation in South Korea, 1997-2023.
The study identified the presence of ermB and tetM genes in Streptococcus pneumoniae isolates, which confer resistance to azithromycin, erythromycin, and tetracycline. These genes were found in isolates from both invasive and non-invasive pneumococcal diseases.
Overlooked Enterobacterales as hosts of antimicrobial resistance in aquatic environments.
The study identified several AMR genes in environmental Enterobacterales isolates, including blaTEM-1, blaCTX-M, tetA, tetB, tetC, tetL, tetM, sul1, sul2, qnrS, ermB, and mefA, which conferred resistance to various antibiotics such as ampicillin, ceftazidime, cefepime, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and erythromycin.
Prevalence and antimicrobial resistance of methicillin-resistant and methicillin-susceptible Staphylococcus in small- to medium-scale and large-scale dairy farms in Thailand.
The study identified several AMR genes and mutations in Staphylococcus isolates from small- to medium-scale and large-scale dairy farms in Thailand, highlighting differences in resistance profiles between farm types.
TRENDS IN MULTIPLE ANTIBIOTIC RESISTANCE AMONG PREDOMINANT HOSPITAL ISOLATES: ANNUAL VARIATIONS AND PEAK SEASONAL PATTERNS
The study identified mecA, vanA, and tetM as key resistance genes in Staphylococcus aureus isolates with high multiple antibiotic resistance indices, indicating the presence of methicillin-resistant and vancomycin-resistant strains.
Global analysis of the genomic diversity, antimicrobial resistance and potential vaccine candidates carried by the major global bovine pathogen Streptococcus uberis.
The study identified 35% of S. uberis isolates carrying acquired antimicrobial resistance genes, including ant(6)-la, aph(3')-lla, tetL, tetM, tetS, lnuC, and lnuD. Additionally, mutations in penicillin-binding proteins pbp2b (N366I, T402I) and pbp2x (E381K, Q554E, V590A, G600E) were associated with reduced penicillin susceptibility.
Characteristics of Staphylococcus saprophyticus Isolated from Humans and Animals.
The study identified several AMR genes in Staphylococcus saprophyticus strains isolated from humans and animals, including blaZ, mecA, ermA, ermB, tetM, fusB, and mupA, which confer resistance to various antibiotics such as beta-lactams, macrolides, tetracyclines, fusidic acid, and mupirocin.
Staphylococcus epidermidis in Acute Myeloid Leukemia: A Comparative Genomic Study Against Non-AML Isolates.
The study identified several AMR genes in S. epidermidis isolates from AML patients, including mecA, mecR1, qacA, ermC, tetM, cfrA, ANT(4′)-Ib, blaZ, dfrG, cat, and mecI, which were associated with increased resistance to various antibiotics.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
The study identified 50 acquired resistance genes and seven chromosomal-mediated gene mutations in Salmonella populations from Thai canal water, highlighting the prevalence of multidrug-resistant strains and the diversity of resistance mechanisms.
Epidemiology of potential source, risk attribution of Clostridium perfringens from Egyptian broiler farms and genetic diversity of multidrug resistance strains.
The study identified multiple AMR genes in Clostridium perfringens isolates from Egyptian broiler farms, including aminoglycoside, beta-lactam, macrolide, quinolone, sulfonamide, tetracycline, and trimethoprim resistance genes. High prevalence of multidrug-resistant strains was observed.
Epidemiology of potential source, risk attribution of Clostridium perfringens from Egyptian broiler farms and genetic diversity of multidrug resistance strains.
The study identified multiple AMR genes in Clostridium perfringens isolates from Egyptian broiler farms, including aminoglycoside, beta-lactam, macrolide, quinolone, sulfonamide, tetracycline, and trimethoprim resistance genes. High prevalence of multidrug-resistant strains was observed.
Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China.
The study identified the optrA gene as the primary mechanism of linezolid resistance in Enterococcus species from cancer patients in China, along with other resistance genes such as tet(M), erm(A), and erm(B).
Genomic profiling of cefotaxime-resistant Haemophilus influenzae from Norway and Sweden reveals extensive expansion of virulent multidrug-resistant international clones.
The study identifies the expansion of multidrug-resistant Haemophilus influenzae clones with cefotaxime resistance, primarily due to mutations in the ftsI gene encoding penicillin-binding protein 3 (PBP3). These mutations lead to cross-resistance to multiple beta-lactam antibiotics.
Colorectal cancer-associated Streptococcus gallolyticus: a hidden diversity expose.
The study identified multiple antibiotic resistance genes in Streptococcus gallolyticus subsp. gallolyticus (SGG) isolates associated with colorectal cancer, including aadE, ermB, aphA-3, and tetM, which confer resistance to streptomycin, macrolides/lincosamides/streptogramin B, kanamycin, and tetracycline, respectively.
Epidemiology and genetic characteristics of Clostridioides difficile isolates in Northwest China.
The study identified 13 resistance genes, including cdeA, ermB, 23S rRNA, vanXYG, tetM, and tetB(P), along with mutations in gyrA, gyrB, and rpoB, conferring resistance to fluoroquinolones, macrolides, lincosamides, glycopeptides, tetracyclines, and rifamycins in Clostridioides difficile isolates from Northwest China.
Antimicrobial activity of Pediococcus pentosaceus strains against diarrheal pathogens isolated from pigs and effect on paracellular permeability of HT-29 cells.
The study identified the tetM gene in Pediococcus pentosaceus SMFM2016-YK1, which confers tetracycline resistance.
Isolation and Molecular Characterization of Three Staphylococcus pseudintermedius Strains from Dogs and Humans in Egypt.
Three Staphylococcus pseudintermedius isolates from dogs and humans in Egypt were characterized. The isolates showed resistance to various antibiotics, including penicillin, tetracycline, aminoglycosides, chloramphenicol, fusidic acid, macrolides, streptothricin, and trimethoprim. None of the isolates carried the mecA gene, which is associated with methicillin resistance.
Profiling Listeria monocytogenes in Hummus, Fresh Produce, and Food Processing Environments in the Western Cape, South Africa.
The study identified the tetM gene conferring resistance to tetracycline, doxycycline, and minocycline in two lineage I, serotype 1/2b, ST5 isolates from RTE hummus. All 20 isolates were found to contain the fosX gene, which encodes resistance to fosfomycin.
CapSeq for Surveillance in Environmental Samples
The study demonstrates the effectiveness of CapSeq in detecting and genotyping bacterial pathogens and antibiotic resistance genes in bovine respiratory disease (BRD) samples, highlighting the presence of various resistance genes such as bla-TEM, bla-ROB, tetM, tetQ, tetS, tetH, tetX, floR, rrs, and rrl.
Comprehensive genomic analysis of antibiotic resistance plasmids in animal-associated Staphylococcus aureus in France.
The study identified multiple antibiotic resistance genes in Staphylococcus aureus isolates from animals, including blaZ, str, cat(pC221), tet(M), aac(6')-aph(2'), and dfrK, which were associated with plasmids and contributed to multidrug resistance.
Navigating an evolving microbial landscape: emerging antimicrobial resistance trends and precision stewardship in Tianjin tertiary hospitals (2021-2023).
The study identified significant trends in antimicrobial resistance (AMR) patterns among clinical isolates from hospitals in Tianjin, highlighting the increasing resistance of Klebsiella pneumoniae to various antibiotics, including carbapenems, and the notable decline in ceftazidime/avibactam resistance in E. coli. Additionally, it noted the emergence of resistance in Acinetobacter baumannii and Pseudomonas aeruginosa to several antimicrobials.
Molecular epidemiology and antibiotic resistance of group B Streptococcus in pregnant women and neonates from Haikou, China: implications for vaccine development and antimicrobial stewardship.
The study identified high rates of tetracycline (89.1%) and clindamycin (55.1%) resistance in GBS strains from Haikou, China. Key resistance genes included mreA, ermB, tetM, catQ, cat(pC194), ant(6)-Ia, aph(3')-III, and aac(6')-aph(2'').
Unveiling community structure, antimicrobial resistance, and virulence factor of a wastewater sample of dairy farm located in mayurbhanj, odisha, india.
The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Molecular Epidemiology, Antimicrobial Resistance, and Virulence Profiles of Staphylococcus aureus from Fish, Aquatic Environments, and Fish Handlers in Southeast Nigeria.
The study identified 19 antimicrobial resistance genes in Staphylococcus aureus isolates from fish, aquatic environments, and fish handlers in Southeast Nigeria, highlighting the presence of multidrug-resistant strains with various resistance mechanisms.
Genomic identification and characterization of Streptococcus oralis group that causes intraamniotic infection.
The study identified the presence of ermB and tet(M) genes in Streptococcus oralis strain RAOG5826, which confer resistance to clindamycin, erythromycin, and tetracycline. Additionally, mutations in penicillin-binding proteins were found to contribute to reduced susceptibility to penicillin and ampicillin.
Phenotypic and genomic analysis of the emerging poultry pathogen Enterococcus cecorum in UK isolates.
The study identifies multiple AMR genes and mutations in UK E. cecorum isolates, including tet(L), tet(M), ant(6)-la, ermB, NarA/NarB, and lnuC, as well as mutations in pbp2x and gyrA that confer resistance to various antibiotics.
Integrative genomic characterization of five Pediococcus acidilactici strains reveals differing probiotic safety profiles.
The study identified plasmid-borne AMR genes such as tet(M) and erm(B) in some Pediococcus acidilactici strains, highlighting the need for careful safety assessments of probiotics.
Antimicrobial resistance reservoirs in salmon and broiler processing environments, sidestreams, and waste discharges.
The study identified several high-risk AMR genes in salmon and broiler processing environments, including multidrug resistance genes TolC and mdtE, tetracycline genes tet(L) and tet(M), aminoglycoside genes APH(3′)-IIIa and APH(6)-Id, and beta-lactam genes mecA and mecR1. Additionally, the study found quinolone-resistant Escherichia coli (QREC) in waste discharges from two broiler processing plants and multidrug resistant (MDR) E. coli in one plant.
Contamination and antimicrobial resistance testing of Staphylococcus aureus isolates from pork in the traditional market at Central Vietnam.
The study found that 100% of retail pork samples from traditional markets in Hue City, Vietnam, were contaminated with Staphylococcus aureus. High resistance rates were observed against penicillin, amoxicillin, and tetracycline, with the tetM, blaZ, and femA genes being the most prevalent AMR genes.
Molecular identification of antibiotic-resistant and virulent Escherichia coli and Staphylococcus aureus isolated from dogs in Southern Benin.
The study identified several antibiotic resistance genes in Escherichia coli and Staphylococcus aureus isolated from dogs in Southern Benin, including blaTEM, tetA, strA-strB, tetK, tetM, and blaZ, which confer resistance to penicillin, tetracycline, and streptomycin.
Autochthonous transmission of extensively drug-resistant Neisseria gonorrhoeae in Germany, 2025.
The study reports four cases of autochthonous transmission of extensively drug-resistant Neisseria gonorrhoeae (XDR-NG) in Germany, 2025. The isolates exhibited high-level resistance to azithromycin, cefixime, and ceftriaxone, with specific genetic determinants including the mosaic penA -60.001 allele, 23S rRNA A2045G mutation, and tetM gene with rpsJ V57M mutation.
Increase of macrolide resistance among Streptococcus pyogenes pharyngitis driven by a mef(A)-msr(D)/emm2-ST55 lineage in Portugal (2014-2019).
The study identifies the emergence of a mef(A)-msr(D) positive emm2-ST55 lineage as a major driver of increased macrolide resistance in Streptococcus pyogenes pharyngitis in Portugal between 2014 and 2019. It also characterizes various macrolide resistance genes including erm(A), erm(B), erm(T), tet(O), and tet(M) associated with different genetic lineages.
Phenotypic and genotypic characterization of ST103 serotype Ia Streptococcus agalactiae isolated from bovine mastitis in China.
The study identified tetracycline resistance genes tetO and tetM, as well as the macrolide resistance gene ermB in ST103 serotype Ia Streptococcus agalactiae isolates from bovine mastitis in China.
Community gut colonization by tet(X4)-positive multidrug-resistant Escherichia coli in healthy individuals from urban residents in Shenzhen, China.
The study identifies tet(X4)-positive multidrug-resistant E. coli in healthy individuals from urban areas in Shenzhen, China, highlighting the presence of tigecycline resistance and other resistance genes in the community gut microbiota.
Hemolytic activity and antibiotic resistance profiles of Staphylococcus aureus isolates from clinical patients.
The study identified the presence of antibiotic resistance genes accA-aphD, tetK, and tetM in Staphylococcus aureus isolates, which confer resistance to gentamicin, tetracycline, and doxycycline. These genes were detected in both MRSA and MSSA isolates, with varying prevalence depending on the isolate type.
Whole genome sequence of multidrug-resistant Staphylococcus haemolyticus and Enterococcus faecalis isolates from public gymnasium equipment reveals evolving infection potential and resistance.
The study identified multiple antibiotic resistance genes in multidrug-resistant Staphylococcus haemolyticus and Enterococcus faecalis isolates from public gymnasium equipment, highlighting their potential to resist various antibiotics and posing a health risk in communal environments.
Multidrug-resistant Pseudomonas aeruginosa: Pathogenesis, resistance mechanisms, and novel therapeutic strategies.
The paper discusses the multidrug resistance mechanisms of Pseudomonas aeruginosa, including beta-lactamases, aminoglycoside modifying enzymes, efflux pumps, and mutations in porin genes. It highlights the role of these mechanisms in antibiotic resistance and the challenges they pose in treating infections.
Acquisition of novel antibiotic resistance genes by the bacterial predator Bacteriovorax sp. As-1.
Bacteriovorax sp. As-1 exhibits resistance to multiple antibiotics, primarily due to mutations in the gyrA gene, specifically S90Y and G94R, which are associated with reduced fluoroquinolone susceptibility.
A systematic review of tetracyclines for nontuberculous mycobacteria: focus on rapidly growing mycobacteria.
The study evaluates the efficacy of tetracyclines against rapidly growing mycobacteria, highlighting tigecycline, omadacycline, and eravacycline as effective treatment options for Mycobacterium abscessus, whereas doxycycline and minocycline show limited effectiveness due to high MIC values.
Antimicrobial resistance in raw cow's milk in Bwegera, Democratic Republic of the Congo: implications for food safety.
High resistance to tetracyclines and vancomycin was observed in enteropathogenic bacteria isolated from raw cow's milk in Bwegera, DRC. The study identified the tet(M) gene as a contributor to tetracycline resistance in Escherichia coli, Klebsiella pneumoniae, and Citrobacter diversus.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Emergence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus ST398 in Wild Birds, Brazil.
The study reports the first detection of livestock-associated Methicillin-Resistant Staphylococcus aureus ST398 in wild birds in Brazil, highlighting the emergence of antimicrobial-resistant S. aureus in a protected Atlantic Forest fragment. The MRSA isolates exhibited a broad resistome, including genes for resistance to multiple antimicrobial classes.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
High-resolution genomic and molecular characterization of vancomycin-resistant enterococci from hospitalized patients in a tertiary care center in Riyadh, Saudi Arabia.
The study identified vanA, tet(M), erm(B), aac(6')-Ii, and aad(6) as key vancomycin-resistant genes in E. faecium, along with liaR and liaS mutations linked to daptomycin resistance.
Comparative assessment of annotation tools reveals critical antimicrobial resistance knowledge gaps in Klebsiella pneumoniae.
The study identifies various AMR genes and mutations in Klebsiella pneumoniae, highlighting knowledge gaps in existing annotation tools and databases for accurate resistance prediction.
Molecular epidemiology and geographical variation of methicillin-resistant Staphylococcus aureus: a multicentre study across Xinjiang, China.
The study identified several AMR genes in MRSA isolates from Xinjiang, China, including blaZ, ermB, aph(3')-III, aac(6')-aph(2''), ermC, tetM, and tetK, which confer resistance to various antibiotics such as penicillin, oxacillin, erythromycin, clindamycin, kanamycin, tetracycline, and gentamicin.
Genetic insights into antimicrobial resistance and virulence characteristics of Salmonella enterica isolated from Nile tilapia sourced from retail markets in Thailand.
The study identified multiple antimicrobial resistance (AMR) genes in Salmonella enterica isolates from Nile tilapia, including beta-lactamases (bla TEM−1B, bla CTX−M−55, bla CTX−M−14, bla LAP−2), quinolone resistance genes (qnrS1, qnrS13), tetracycline resistance genes (tet(A), tet(B), tet(M)), aminoglycoside resistance genes (aadA2, aph(3’’)-Ib, aph(6)-Id, aac(6’)-Ia), sulfonamide resistance genes (sul1, sul2, sul3), florfenicol resistance gene (floR), and efflux pump systems (mdsABC, mdtK).
High colonization by multidrug-resistant and virulent Staphylococcus aureus genotypes among critically ill patients in the COVID-19 pandemic in a Brazilian hospital.
The study identified multiple AMR genes in MRSA isolates from critically ill patients during the COVID-19 pandemic, including erm(C), msr(A), mph(C), smr, aph(3')-III3a, and various virulence genes such as sasG, ebpS, scn, egc_cluster, fnbpB, cna, and pvl.
Multidrug Resistance and Virulence Gene Profiles of E. coli in Broiler Chickens: A Study From Noakhali, Bangladesh.
The study identified high levels of multidrug resistance (MDR) in E. coli isolates from broiler chickens and environmental samples in Bangladesh, with a significant prevalence of virulence genes such as iroN, ompT, hlyF, iss, and iutA.
Commensal Clostridia in the preterm gut as reservoirs of antimicrobial resistance: susceptibility profiles, and resistance genes.
The study identifies tetracycline and clindamycin resistance genes (tet and erm) in various Clostridia species from preterm infants, highlighting their role as reservoirs of antimicrobial resistance.
Cervicovaginal microbiome composition and absolute quantity are associated with pelvic inflammatory disease.
The study found that PID cases were associated with higher abundance of G. vaginalis and other CST IV organisms, while controls had higher levels of L. crispatus. No specific AMR genes were characterized in this paper.
Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.
The study identified multiple AMR genes in Citrobacter freundii isolates from Egyptian livestock, including bla TEM, bla CTX-M, bla OXA-10, bla CMY-2, qnrA, aadA1, sul2, dfrA1, ermB, tet(M), int1, and mcr-1, which confer resistance to various antibiotics.
Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.
The study identified multiple AMR genes in Citrobacter freundii isolates from Egyptian livestock, including bla TEM, bla CTX-M, bla OXA-10, bla CMY-2, qnrA, aadA1, sul2, dfrA1, ermB, tet(M), int1, and mcr-1, which confer resistance to various antibiotics.
The prevalence and molecular epidemiology of Clostridioides difficile in hospital-based pediatric populations in China.
The study identified ermB as a major determinant of clindamycin resistance, gyrA T82I mutations as a key factor in moxifloxacin resistance, and tet(M) as a contributor to tetracycline resistance in C. difficile isolates from pediatric populations in China.
Distribution of Staphylococcus aureus drug resistance genes, biofilm formation and cell wall characteristics in dairy cattle from dairy farms in Northeast China.
The study identified various antibiotic resistance genes in Staphylococcus aureus isolates from dairy cattle in Northeast China, including tetM, aph(3')-III, ermC, aac(6')/aph(2'), grlB, gyrB, blaZ, and mecA, which confer resistance to tetracycline, aminoglycosides, erythromycin, fluoroquinolones, and beta-lactams.
Genomic characterization of Staphylococcus aureus isolated from mastitis in small ruminants in Sardinia, Italy.
The study identified erm(T), tet(K), and tet(M) as the primary AMR genes in S. aureus isolates from mastitis in Sardinia, with low resistance rates to erythromycin and tetracycline.
Serotypes, antibiotic susceptibility and whole-genome characterization of Streptococcus pneumoniae in Sichuan Province, China in 2023.
The study identified nine resistance genes in 105 Streptococcus pneumoniae strains, including erm(B), mef(A), msr(D), tet(M), and others. High resistance rates were observed to erythromycin, clindamycin, tetracycline, and trimethoprim/sulfamethoxazole, with a multidrug resistance rate of 85.71%.
Antimicrobial resistance and virulence gene profiles of Enterococcus faecalis and Enterococcus faecium isolated from subclinical bovine mastitis milk and cow dung.
The study identified vanA, tetM, ermB, vanB, and tetK as the main antimicrobial resistance genes in Enterococcus faecalis and Enterococcus faecium isolates from subclinical bovine mastitis milk and cow dung samples.
Co-selection of genetic antibiotic resistance in Streptococcus pneumoniae after repeated azithromycin mass drug administrations in Niger.
Repeated azithromycin mass drug administrations in Niger led to the co-selection of genetic resistance to macrolides, tetracyclines, and trimethoprim-sulfamethoxazole in Streptococcus pneumoniae, primarily mediated by mobile genetic elements.
Genomic insights into the expansion of meropenem-resistant GPSC1-CC320 Streptococcus pneumoniae serotype 19A isolates from children under 5 years of age with invasive infections, 2018-2024.
The study identifies the presence of tet(M), erm(B), mef(A), and msr(D) genes in meropenem-resistant Streptococcus pneumoniae serotype 19A isolates, which confer resistance to tetracycline, erythromycin, and azithromycin. These isolates also exhibit a unique combination of pbp alleles (pbp1a-13, pbp2b-11, pbp2x-16) that contributes to their resistance profile.
Elucidation of population-based bacterial adaptation to antimicrobial treatment by single-cell sequencing analysis of the gut microbiome of a hospital patient.
The study identified 29 ARG subtypes across eight types in 13 known, five unknown, and 18 unclassified species, highlighting the complex and dynamic nature of antimicrobial resistance in the gut microbiome. Notably, the cfr(C) gene was detected in 11 bacterial species following antimicrobial treatment, with mutation patterns characterized in several species.
Unveiling Equine Abortion Pathogens: A One Health Perspective on Prevalence and Resistance in Northwest China.
The study identified multiple antibiotic resistance genes in equine abortion pathogens, including CTX-M, TEM-1, TetM, ermA/B/C, qnrA/B, sul1/2, dfrA1/5, SHV, OXA-1, OXA-23/48/58, mecA/B/C, IMP-1/2, NDM-1, VIM-1/2, and vanA/B/C, highlighting the widespread resistance to various antibiotics among these pathogens.
Emergence of Multidrug-Resistant and Biofilm-Producing Staphylococcus aureus from Raw Poultry in Algeria: Implications for Public Health.
The study identified several AMR genes in S. aureus isolates from raw poultry in Algeria, including blaZ, mecA, tet(M), tet(K), tet(S), erm(B), and erm(C). These genes were associated with resistance to penicillin, methicillin, tetracycline, and erythromycin.
Prophage φEr670 and Genomic Island GI_Er147 as Carriers of Resistance Genes in Erysipelothrix rhusiopathiae Strains.
The study identifies the prophage φEr670 carrying lnuB and lsaE genes, and the genomic island GI_Er147 carrying ant(6)-Ia, spw, lnu(J), and vat family genes in E. rhusiopathiae strains. These genes confer resistance to lincomycin, tetracycline, streptomycin, and spectinomycin.
Molecular resistance mechanisms to newly approved antibiotics (2017-2025) in WHO priority pathogens.
The paper reviews molecular resistance mechanisms to newly approved antibiotics in WHO priority pathogens, identifying various beta-lactamases, efflux pumps, and target site modifications that confer resistance.
Virulence profiles and antibiotic resistance patterns of Escherichia coli isolated from clinical samples and chicken meat: Implications for public health and food safety.
The study identified several antibiotic resistance genes in E. coli isolates from clinical and chicken meat samples, including ermA, tetM, blaTEM, qnrS, and aadA1, highlighting the prevalence of multidrug resistance and the potential public health risks associated with contaminated food sources.
Drug-resistant genes, virulence characteristics, and molecular typing of clindamycin-resistant Streptococcus agalactiae in late pregnancy.
The study identified several AMR genes and mutations in clindamycin-resistant S. agalactiae, including ermB, mreA, tetM, tetO, aph(3')-III, gyrA, and parC. Mutations in gyrA and parC were associated with levofloxacin resistance.
Tetracycline resistance determinants among streptococci of serological group G and L.
The study identifies tet(M) and tet(O) genes as the primary tetracycline and minocycline resistance determinants in streptococci of serological groups G and L.
Characterisation of a tet(M)-carrying plasmid from Neisseria meningitidis.
Characterisation of a tet(M)-carrying plasmid from Neisseria meningitidis.
Characterization of conjugative transposon Tn5251 of Streptococcus pneumoniae.
Characterization of conjugative transposon Tn5251 of Streptococcus pneumoniae.
Molecular evolution of the tet(M) gene in Gardnerella vaginalis.
Molecular evolution of the tet(M) gene in Gardnerella vaginalis.
Molecular evolution of the tet(M) gene in Gardnerella vaginalis.
Host mutations (miaA and rpsL) reduce tetracycline resistance mediated by Tet(O) and Tet(M).
Mutations in the miaA and rpsL genes reduce tetracycline resistance mediated by Tet(O) and Tet(M) in Salmonella typhimurium and Escherichia coli.
Molecular characterization of penicillin-resistant Streptococcus pneumoniae isolates from Bulgaria.
The study identified multiple penicillin-resistant Streptococcus pneumoniae isolates from Bulgaria, characterizing their resistance mechanisms through molecular techniques. Key findings include the identification of specific penicillin-binding protein genes (pbp1a, pbp2b, pbp2x) and resistance genes (ermB, mefE, tetM, cat) associated with resistance to penicillin, erythromycin, tetracycline, and chloramphenicol.
Characterization of conjugative transposon Tn5251 of Streptococcus pneumoniae., The nucleotide sequence of the tetracycline resistance determinant tetM from Ureaplasma urealyticum., Molecular evolution of the tet(M) gene in Gardnerella vaginalis., Cloning and nucleotide sequence of a chromosomally encoded tetracycline resistance determinant, tetA(M), from a pathogenic, methicillin-resistant strain of Staphylococcus aureus., Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)., Nucleotide sequence of the tetM tetracycline resistance determinant of the streptococcal conjugative shuttle transposon Tn1545., Rapid pneumococcal evolution in response to clinical interventions., Whole genome analysis of a livestock-associated methicillin-resistant Staphylococcus aureus ST398 isolate from a case of human endocarditis.
No comments yet. Be the first to comment!