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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline resistance ribosomal protection protein Tet(O)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Tet(O) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 197 | TETRACYCLINE, tetracycline +6 | Streptococcus pneumoniae +95 | Italy, Iowa, Alberta, Canada, Brazil, North Carolina|Ohio, Asia|Australasia, Spain, United States, Portugal, Turkey, France, Vietnam, United States|USA, Portugal|Germany|Italy, Venezuela, Denmark|United States|Italy|Germany, United States|Great Britain, Iran, Japan, Denmark|Europe, Tanzania, China, Kenya, Taiwan, Europe, Spain|Canada|Brazil|Thailand, Alberta, USA|France|Portugal|China|Brazil|Germany|Sweden|Italy|Spain|Denmark|Japan|Korea|Europe|Asia|North America, Latvia, Ireland|Iran|Kenya, USA, Belgium, Global, South Africa, Canada, Poland, South Korea, GA, USA, Israel, Denmark, global, Republic of Korea, Mongolia, North Carolina, India, Spain|Basque Country, Argentina, Cairo, Egypt|Egypt, China|United States of America|United Kingdom|Canada|Spain|Netherlands|France|Germany|Denmark|Europe|North America, Europe|North America|United States, Poland|Ukraine, Northeastern Ohio, the United States|Northeastern Ohio, Sweden, Thailand, Mississippi State|Mississippi, Cambodia, Tunisia, Minnesota, Ghana, Georgia, Chiang Mai province, Northern Thailand|Thailand, Peru, North of Tunisia, Europe|Taiwan|USA, Germany, Thailand|Vietnam, Shenzhen, China, Thailand|China|Spain|USA|UK|Australia|Canada|Japan, Michigan, USA|Michigan, central China, Germany|Vietnam, Greece, China|UK|Canada|Thailand|Netherlands|USA|Denmark|Spain|other nations, Saudi Arabia, Guangzhou, Bulgaria, Southern Spain, Ecuador, North America, Shahrekord, Iran|Iran, Chiba prefecture, Japan, Hubei Province, China, Asia|Europe|America, Hangzhou, China|China, Asia|North America, China|Netherlands|Thailand, Victoria, Australia, Lebanon | 1988, 1995, 1996, 1998, 2001, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | FM178797.1 | CAQ76847.1 |
| tet(O) | Card DatabaseResFinder Database | 2 | MINOCYCLINE, TETRACYCLINE +1 | Campylobacter jejuni +1 | - | 1988 | M18896.2 | AAA23033.2 |
| tetO | Reslit | 115 | tetracycline, doxycycline +3 | Streptococcus pneumoniae +65 | Europe|North America|Asia, Argentina, Kansas|United States, Belgium|Spain|Italy|Germany, Maine|New Hampshire, Spain, Canada|United States of America|Thailand|North America, China, France, Southern Alberta, Canada, North China, International Space Station, South Africa, California, USA, Japan, New Zealand, Vermont|United States, Canada|Southwestern Alberta, Sweden, Europe|Southern and Western Ireland, New Hampshire, USA, Switzerland|chicken, Ethiopia, Sikkim|India, France|New Caledonia|La Réunion Island|French Guiana|French Polynesia|Guadeloupe|Madagascar|Tunisia|India, Myanmar, United States, Chile, Sicily, South China, Vietnam, US, South Korea, Europe, Italy, Malaysia|Terengganu, Malaysia, Portugal, Europe|North America|Netherlands|Denmark|Pennsylvania|United States|France, Mexico, St. Louis, MO, Canada|China|Iran|Poland|United States|Turkey|South Korea|Hong Kong|India|Germany|France|Italy|Spain|Japan|Brazil|Australia|Russia|Mexico|Egypt|Saudi Arabia|South Africa|New Zealand|Sweden|Norway|Denmark|Finland|Iceland|Switzerland|Austria|Belgium|Netherlands|Luxembourg|Portugal|Greece|Czech Republic|Hungary|Romania|Bulgaria|Serbia|Croatia|Slovenia|Slovakia|Ukraine|Israel|Jordan|Lebanon|Syria|Iraq|Afghanistan|Pakistan|Bangladesh|Myanmar|Vietnam|Thailand|Malaysia|Indonesia|Philippines|Singapore|Brunei|Cambodia|Laos|Mongolia|North Korea|Taiwan|Macau|Macao|Taipei|Shanghai|Beijing|Guangzhou|Shenzhen|Chengdu|Chongqing|Wuhan|Hangzhou|Nanjing|Xi'an|Tianjin|Harbin|Changchun|Shenyang|Dalian|Qingdao|Ningbo|Wenzhou|Xiamen|Fuzhou|Quanzhou|Zhengzhou|Luoyang|Kaifeng|Zhuhai|Shantou|Zhongshan|Huizhou|Meizhou|Shaoguan|Heyuan|Zhanjiang|Yangjiang|Maoming|Zhaoqing|Jiangmen|Yangzhou|Nantong|Suzhou|Wuxi|Changzhou|Zhenjiang|Taizhou|Lishui|Huzhou|Jiaxing|Shaoxing|Haining|Anqing|Hefei|Huangshan|Wuhu|Ma'anshan|Chizhou|Tongling|Anhui|Hubei|Hunan|Guangxi|Yunnan|Guizhou|Sichuan|Shaanxi|Gansu|Qinghai|Tibet|Inner Mongolia|Xinjiang|Ningxia|Henan|Shanxi|Hebei|Shandong|Jiangsu|Zhejiang|Fujian|Guangdong|Hainan|Jiangxi, Europe|USA|Portugal|Germany|Australia|China|India|Pakistan|Sweden|Colorado, Alberta, Varsovian|Poland, Brazil, Norway, Iran, Central Georgia, Thailand, Northeast Ohio, Indonesia, New Caledonia, Beijing|China, Poland, Southern Malaysia, Yangtze River Mouth, China, Turkey, southeastern United States, Danakil Depression, Afar Region, Ethiopia, Europe|Belgium|France|Germany|Netherlands|United Kingdom, India|Japan|Europe|North America|global, China|Minhang District, Shanghai, Bulgaria, China|Xinjiang, Romania, Vietnam|Germany|South Korea, China|Shandong Province, China | 1988, 2003, 2008, 2009, 2011, 2014, 2016, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | JM426721|JM426722|JM426723|JM426724|JM426725|JM426726|JM426727|JM426728|JM426729|JM426730|JM426731|JM426732|JM426733|JM426734|JM426735|JM426736|JM426737|JM426738|JM426739|JM426740|JM426741|JM426742|JM426743|JM426744 | - |
| TetO | Reslit | 2 | tetracycline | Campylobacter jejuni +3 | - | 2013, 2021 | - | - |
| tet O | Reslit | 5 | tetracycline | Streptococcus pyogenes +5 | Spain, Yangzhou City, Europe, North America | 2017, 2018, 2021, 2023 | KX981212|KX981438|KY048431|KY048441 | - |
| TETO | Reslit | 2 | tetracycline | Bacteroidetes +4 | Alberta, Canada | 2019, 2024 | - | - |
| tet(O)/tet(32) | Reslit | 1 | tetracycline | Campylobacter spp. | USA|Peru|Egypt|Cambodia|Kenya | 2020 | - | - |
| tet (O) | Reslit | 3 | tetracycline | Campylobacter coli +1 | Ghana, Spain|Basque Country, Europe | 2020, 2021, 2025 | CP013733|CP017875|CP011017|SRR13362733|SRR13362734|SRR13362735|SRR13362736|SRR13362737|SRR13362738|SRR13362739|SRR13362740|SRR13362741|SRR13362742|SRR13362743|SRR13362744|SRR13362745|SRR13362746|SRR13362747|SRR13362748|SRR13362749|SRR13362750|SRR13362751|SRR13362752|SRR13362753|SRR13362754|SRR13362755|SRR13362756|SRR13362757|SRR13362758|SRR13362759|SRR13362760|SRR13362761|SRR13362762|SRR13362763|SRR13362764|SRR13362765|SRR13362766|SRR13362767|SRR13362768|SRR13362769|SRR13362770|SRR13362771|SRR13362772|SRR13362773|SRR13362774|SRR13362775|SRR13362776|SRR13362777|SRR13362778|SRR13362779|SRR13362780|SRR13362781|SRR13362782|SRR13362783|SRR13362784|SRR13362785|SRR13362786|SRR13362787|SRR13362788|SRR13362789|SRR13362790|SRR13362791|SRR13362792|SRR13362793|SRR13362794|SRR13362795|SRR13362796|SRR13362797|SRR13362798|SRR13362799|SRR13362800|SRR13362801|SRR13362802 | - |
Molecular ecology of tetracycline resistance: development and validation of primers for detection of tetracycline resistance genes encoding ribosomal protection proteins.
The study identified and characterized multiple tetracycline resistance genes encoding ribosomal protection proteins (RPPs) including tet(M), tet(O), tet(W), tet(Q), tet(S), tet(T), tetB(P), and otrA. These genes were detected in various bacterial species and environments, highlighting their prevalence and potential for horizontal gene transfer.
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Mechanism of Tet(O)-mediated tetracycline resistance.
The study identifies Tet(O) as a ribosomal protection protein that confers tetracycline resistance by interacting with the post-translocational ribosome and inducing conformational changes that facilitate tetracycline release.
Isolation of Tetracycline-Resistant Megasphaera elsdenii Strains with Novel Mosaic Gene Combinations of tet(O) and tet(W) from Swine
The study identifies novel mosaic gene combinations of tet(O) and tet(W) in tetracycline-resistant Megasphaera elsdenii strains from swine, demonstrating that these genes confer tetracycline resistance when cloned into E. coli.
Presence of the tet(O) Gene in Erythromycin- and Tetracycline-Resistant Strains of Streptococcus pyogenes and Linkage with either the mef(A) or the erm(A) Gene.
The study identifies the tet(O) gene in erythromycin- and tetracycline-resistant Streptococcus pyogenes strains and shows its linkage with mef(A) or erm(A) genes.
Six-month multicenter study on invasive infections due to group B streptococci in Argentina.
The study identified several AMR genes in group B streptococci, including aac(6')-aph(2"), mefA, ermTR, tetM, and tetO, which confer resistance to aminoglycosides, macrolides, and tetracyclines. These genes were experimentally validated through PCR and susceptibility testing.
Diverse tetracycline resistance genotypes of Megasphaera elsdenii strains selectively cultured from swine feces.
The study identifies multiple tetracycline resistance genotypes in Megasphaera elsdenii strains, including novel mosaic genes such as tet(OWO)-1 and tet(OWO)-2, which confer high levels of tetracycline resistance.
Diverse tetracycline resistance genotypes of Megasphaera elsdenii strains selectively cultured from swine feces.
Incidence of antibiotic resistance in Campylobacter jejuni isolated in Alberta, Canada, from 1999 to 2002, with special reference to tet(O)-mediated tetracycline resistance.
The study identifies the tet(O) gene as the primary mediator of tetracycline resistance in Campylobacter jejuni isolates from Alberta, Canada, with high-level resistance linked to specific nucleotide substitutions in the gene.
Phenotypic and molecular characteristics of Streptococcus agalactiae isolates recovered from milk of dairy cows in Brazil.
The study identified erm(B), tet(O), and tet(M) as the primary genes responsible for erythromycin and tetracycline resistance in Streptococcus agalactiae isolates from dairy cows in Brazil.
Nucleotide sequences and comparison of two large conjugative plasmids from different Campylobacter species.
Distribution and molecular analysis of mef(A)-containing elements in tetracycline-susceptible and -resistant Streptococcus pyogenes clinical isolates with efflux-mediated erythromycin resistance.
Identification and characterization of a major subgroup of conjugative Campylobacter jejuni plasmids.
Analysis of the prevalence of tetracycline resistance genes in clinical isolates of Enterococcus faecalis and Enterococcus faecium in a Japanese hospital.
Mosaic structure of a multiple-drug-resistant, conjugative plasmid from Campylobacter jejuni.
Phenotypic and genotypic characteristics of Streptococcus porcinus isolated from human sources.
The study identified the presence of tet(M) and tet(O) genes in tetracycline-resistant Streptococcus porcinus isolates from human sources, highlighting the role of these genes in tetracycline resistance.
Development and Application of Real-Time PCR Assays for Quantification of Genes Encoding Tetracycline Resistance
The study developed and validated real-time PCR assays to quantify ten major classes of tetracycline resistance genes (tet) in microbiome samples, revealing significant differences in tet gene abundance between bovine and swine manures, with swine manures showing higher levels. Composting significantly reduced tet gene abundance.
Campylobacter coli in swine production: antimicrobial resistance mechanisms and molecular epidemiology.
Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef(I).
The study identified a novel mef gene subclass, mef(I), in pneumococci with efflux-mediated erythromycin resistance. It also characterized the presence of tet(M) and tet(O) genes contributing to tetracycline resistance in certain isolates.
Simultaneous detection of nine antibiotic resistance-related genes in Streptococcus agalactiae using multiplex PCR and reverse line blot hybridization assay.
The study developed a multiplex PCR and reverse line blot hybridization assay to detect nine antibiotic resistance-related genes in Streptococcus agalactiae, including erm(B), erm(A/TR), mef(A/E), tet(M), tet(O), aphA-3, aad-6, int-Tn, and mreA. These genes were found to be associated with resistance to macrolides, lincosamides, streptogramin B, tetracyclines, and aminoglycosides.
Distribution of Tetracycline Resistance Genes in Actinobacillus pleuropneumoniae Isolates from Spain.
The study identified tet(B), tet(O), tet(H), and tet(L) genes in Actinobacillus pleuropneumoniae isolates from Spain, all of which confer tetracycline resistance through efflux mechanisms.
Distribution of tetracycline resistance genes in Actinobacillus pleuropneumoniae isolates from Spain.
Antibiotic susceptibility of Bifidobacterium thermophilum and Bifidobacterium pseudolongum isolates from animal sources.
The study identified the presence of tetracycline resistance genes tet(O) and tet(W), as well as the erythromycin resistance gene erm(X), in Bifidobacterium thermophilum and Bifidobacterium pseudolongum isolates from animal sources.
Monitoring and Source Tracking of Tetracycline Resistance Genes in Lagoons and Groundwater Adjacent to Swine Production Facilities over a 3-Year Period
The study identified and characterized seven tetracycline resistance genes (tet(M), tet(O), tet(Q), tet(W), tet(C), tet(H), and tet(Z)) in lagoons and groundwater near swine production facilities over a 3-year period. These genes were consistently detected in groundwater and lagoon samples, with varying frequencies and concentrations depending on the location and sampling time.
Antibiotic resistance of enterococci in American bison (Bison bison) from a nature preserve compared to that of Enterococci in pastured cattle.
The study identified ermB and tetO as the primary erythromycin and tetracycline resistance genes in enterococci from both bison and cattle, with tetM also found in some bison isolates. Ciprofloxacin resistance was noted but not linked to specific mutations.
Emergence of a tetracycline-resistant Campylobacter jejuni clone associated with outbreaks of ovine abortion in the United States.
The study identifies the tet(O) gene as the primary determinant of tetracycline resistance in a dominant Campylobacter jejuni clone associated with ovine abortion outbreaks in the United States.
Quantitative PCR monitoring of antibiotic resistance genes and bacterial pathogens in three European artificial groundwater recharge systems.
The study identified the presence of antibiotic resistance genes including tetO, ermB, mecA, blaSHV-5, ampC, and vanA in reclaimed water from three European artificial groundwater recharge systems. These genes were detected using real-time qPCR, indicating their potential impact on the environment.
Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids.
The study identifies several AMR genes, including bla ROB-1, tet(B), tet(H), tet(O), strA, and sul2, which are responsible for multidrug resistance in Pasteurella multocida. These genes are located on small plasmids and contribute to resistance against beta-lactams, tetracyclines, streptomycin, and sulfamethoxazole.
Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.
Human group A streptococci virulence genes in bovine group C streptococci.
The study identified antimicrobial resistance genes erm(B), erm(A), linB, tet(M), and tet(O) in bovine group C streptococci, indicating their potential role in multidrug resistance and horizontal gene transfer.
Macrolide and tetracycline resistance and emm type distribution of Streptococcus pyogenes isolates recovered from Turkish patients.
The study identified erm(TR) as the primary macrolide resistance gene and tet(O) as the most common tetracycline resistance gene in Streptococcus pyogenes isolates from Turkey.
Diversity and mobility of integrative and conjugative elements in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis.
The study identified various AMR genes including erm(B), linB, lnuD, tet(M), tet(S), and tet(O) associated with resistance to macrolides, lincosamides, and tetracyclines in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis.
The antimicrobial resistance patterns and associated determinants in Streptococcus suis isolated from humans in southern Vietnam, 1997-2008.
The study reports the presence and expression of tet(L) in Streptococcus suis strains and highlights the co-expression of multiple tetracycline resistance genes contributing to high MIC levels against tetracycline.
Slaughterhouse pigs are a major reservoir of Streptococcus suis serotype 2 capable of causing human infection in southern Vietnam.
The study identified tetracycline resistance genes tet(M), tet(O), and tet(L), and erythromycin resistance gene erm(B) in Streptococcus suis serotype 2 strains isolated from slaughterhouse pigs in southern Vietnam.
Genetic resistance elements carrying mef subclasses other than mef (A) in Streptococcus pyogenes
The study identifies various mef subclasses (mef(E), mef(I), mef(A/E), and a novel mef) associated with resistance genes (tet(M), tet(O), and catQ) in Streptococcus pyogenes, highlighting the diversity of genetic elements involved in macrolide and tetracycline resistance.
The gut as reservoir of antibiotic resistance: microbial diversity of tetracycline resistance in mother and infant.
The study identified various tetracycline resistance genes, including tet(M), tet(L), erm(T), tet(W), tet(O), and tet(X), in the gut microbiota of a mother and her infant. It also discovered a novel composite transposon, Tn 6079, carrying tet(M), tet(L), and erm(T) in the infant's gut, highlighting the potential for horizontal gene transfer and maternal transmission of antibiotic resistance.
Persistence of antibiotic resistance: evaluation of a probiotic approach using antibiotic-sensitive Megasphaera elsdenii strains to prevent colonization of swine by antibiotic-resistant strains.
The study identified tetracycline resistance genes tet(O) and tet(W) in Megasphaera elsdenii strains, which were experimentally validated to confer tetracycline resistance.
Functional metagenomics reveals previously unrecognized diversity of antibiotic resistance genes in gulls.
The study identified numerous antibiotic resistance (AR) genes in gulls, including both known and previously undescribed ones. It highlights the significant diversity of AR genes in gulls, emphasizing their potential role in spreading resistance genes between human and environmental habitats.
Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis.
The study identified tetracycline resistance genes tet(M) and tet(O), the erythromycin resistance gene erm(B), and the streptomycin resistance gene aadA in Streptococcus canis isolates, highlighting the presence of antimicrobial resistance mechanisms in this species.
Resistance mechanisms in Campylobacter jejuni.
The paper reviews the resistance mechanisms in Campylobacter jejuni, focusing on fluoroquinolone, macrolide, beta-lactam, tetracycline, and aminoglycoside resistance. Key mechanisms include mutations in gyrA, efflux pumps like CmeABC, modifications of 23S rRNA, and the presence of resistance genes such as aphA-3, TetO, and blaOXA-61.
Tetracycline resistance genes acquired at birth
The study identified tetracycline resistance genes (tet(M), tet(O), tet(Q), and tet(W)) in the microbiota of newborns and their mothers, highlighting differences in gene prevalence based on delivery mode.
Pharmacodynamics of doxycycline and tetracycline against Staphylococcus pseudintermedius: proposal of canine-specific breakpoints for doxycycline.
The study identifies tetracycline resistance genes tet(M), tet(K), and tet(O) in Staphylococcus pseudintermedius isolates and proposes canine-specific breakpoints for doxycycline susceptibility testing.
Genetic diversity and antimicrobial susceptibility of Campylobacter jejuni isolates associated with sheep abortion in the United States and Great Britain.
The study identified the tetracycline resistance gene tet(O) in Campylobacter jejuni isolates associated with sheep abortion, highlighting its role in tetracycline resistance and the impact of antimicrobial use on the prevalence of resistant clones.
Diversity, distribution and quantification of antibiotic resistance genes in goat and lamb slaughterhouse surfaces and meat products.
The study identified various tetracycline, sulfonamide, and beta-lactam resistance genes in goat and lamb slaughterhouse surfaces and meat products, highlighting the prevalence of tet genes and their potential role in the spread of antibiotic resistance.
Tetracycline Resistance Genes in Campylobacter jejuni and C. coli Isolated From Poultry Carcasses.
The study identified the presence of tet(O) and tet(A) genes in Campylobacter isolates from poultry carcasses in Iran, highlighting the high prevalence of tetracycline resistance in these isolates.
Transduction of the Streptococcus pyogenes bacteriophage Φm46.1, carrying resistance genes mef(A) and tet(O), to other Streptococcus species.
The study demonstrates the transduction of the bacteriophage Φm46.1, which carries the resistance genes mef(A) and tet(O), to various Streptococcus species, confirming its functionality and resistance profiles.
Unraveling antimicrobial resistance genes and phenotype patterns among Enterococcus faecalis isolated from retail chicken products in Japan.
The study identified several antimicrobial resistance genes in Enterococcus faecalis isolated from retail chicken products in Japan, including aac(6')-Ie-aph(2")-Ia, aph(3')-IIIa, ant(6)-Ia, tet(L), tet(M), tet(O), and erm(B). These genes were associated with resistance to various antibiotics such as kanamycin, gentamicin, streptomycin, dihydrostreptomycin, oxytetracycline, and erythromycin.
Sampling and Pooling Methods for Capturing Herd Level Antibiotic Resistance in Swine Feces using qPCR and CFU Approaches.
The study identified several antibiotic resistance genes in swine fecal samples using qPCR, including tetracycline resistance genes (tet(A), tet(B), tet(C), tet(M), tet(O), tet(W)), erythromycin resistance genes (ermB, ermF), sulfonamide resistance genes (sulI, sulII), beta-lactam resistance genes (blaCTX-M-1 group, blaCMY-2, blaSHV family), and glycopeptide resistance gene (vanA).
Prevalence and Antimicrobial Resistance of Campylobacter Isolated from Dressed Beef Carcasses and Raw Milk in Tanzania.
The study identified blaOXA-61, cmeB, tet(O), and aph-3-1 as the primary antimicrobial resistance genes in Campylobacter isolates from raw milk and beef carcasses in Tanzania.
Housefly Larva Vermicomposting Efficiently Attenuates Antibiotic Resistance Genes in Swine Manure, with Concomitant Bacterial Population Changes.
The study found that housefly larva vermicomposting significantly reduces the abundance of tetracycline resistance genes (tet(M), tet(O), tet(Q), tet(W)) and increases the abundance of sulfonamide resistance genes (sul1, sul2) in swine manure. It also observed changes in the bacterial community structure, with a significant decrease in the diversity and richness of bacteria.
Comparative Genomic Analysis of the ICESa2603 Family ICEs and Spread of erm(B)- and tet(O)-Carrying Transferable 89K-Subtype ICEs in Swine and Bovine Isolates in China.
The study identifies and characterizes the ICESa2603 family of integrative and conjugative elements (ICEs) carrying the macrolide resistance gene erm(B) and tetracycline resistance gene tet(O). These ICEs are widespread in swine and bovine isolates in China and contribute to the spread of antibiotic resistance.
Population Structure and Antimicrobial Resistance Profiles of Streptococcus suis Serotype 2 Sequence Type 25 Strains.
The study identifies tetracycline resistance gene tetO and macrolide resistance gene ermB in ST25 S. suis strains, which are carried on integrative and conjugative elements (ICEs).
Antimicrobial Resistance Mechanisms
The paper discusses various mechanisms of antibiotic resistance, including beta-lactamases like blaKPC, blaNDM, blaIMP, and blaVIM, which confer resistance to carbapenems. It also covers aminoglycoside modifying enzymes such as aac(6')-Ib and aac(6')-I, quinolone resistance proteins like qnr, tetracycline resistance genes such as tet(M) and tet(O), macrolide resistance genes like erm, mefA, and mefE, and efflux pump systems like mexAB-oprM and acrAB-tolC.
Antimicrobial resistance of Campylobacter isolates from small scale and backyard chicken in Kenya.
High levels of resistance to ciprofloxacin, nalidixic acid, and tetracycline were observed in Campylobacter isolates from Kenyan chicken, with specific genes (gyrA, tet(O), and tet(A)) identified as contributing to resistance.
Genomic Analysis Reveals Multi-Drug Resistance Clusters in Group B Streptococcus CC17 Hypervirulent Isolates Causing Neonatal Invasive Disease in Southern Mainland China.
The study identifies multiple antibiotic resistance genes, including tetO, ermB, ant6, aphA, ant9, and lnuB, in Group B Streptococcus CC17 isolates from China, highlighting the emergence of multi-drug resistance in these hypervirulent strains.
Comparative genomics of Clostridium bolteae and Clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants.
The study identified numerous antibiotic resistance genes in Clostridium bolteae and Clostridium clostridioforme, including beta-lactamases, glycopeptide resistance operons, macrolide and lincosamide resistance genes, and efflux pumps. Notably, C. bolteae 90B3 exhibited resistance to linezolid, chloramphenicol, florfenicol, and tiamulin due to the presence of the 23S rRNA methyltransferase gene cfr. Additionally, C. clostridioforme 90A8 possessed a VanB-type operon conferring vancomycin resistance.
Virulence and Genomic Feature of Multidrug Resistant Campylobacter jejuni Isolated from Broiler Chicken.
The study identified multiple AMR genes and mutations in Campylobacter jejuni 1655, including gyrA T86I mutation, 23S rRNA A2075G mutation, tetO, aphA, and aadE genes, contributing to resistance against fluoroquinolones, macrolides, tetracycline, and aminoglycosides.
mecA-related structure in methicillin-resistant coagulase-negative staphylococci from street food in Taiwan.
The study identified mecA and mecA Ss genes in methicillin-resistant coagulase-negative staphylococci (MRCoNS) from street food in Taiwan, along with several other resistance genes such as ermA, ermC, tet(M), tet(K), tet(O), and aac(6')-Ie-aph(2'')-Ia, which confer resistance to oxacillin, erythromycin, tetracycline, and gentamicin.
Comparative genomics of Enterococcus spp. isolated from bovine feces.
The study identified several antibiotic resistance genes in Enterococcus spp. isolated from bovine feces, including erm(B) for macrolide-lincosamide-streptogramin B resistance, tet(L), tet(M), and tet(O) for tetracycline resistance, and the vanC operon for glycopeptide resistance.
Nucleotide sequence analysis and expression of a tetracycline-resistance gene from Campylobacter jejuni.
Nucleotide sequence analysis and expression of a tetracycline-resistance gene from Campylobacter jejuni.
Nucleotide sequence analysis and expression of a tetracycline-resistance gene from Campylobacter jejuni.
Nucleotide sequence analysis of tetracycline resistance gene tetO from Streptococcus mutans DL5.
The study identified and characterized the tetracycline resistance gene tetO from Streptococcus mutans DL5, which was cloned and shown to confer tetracycline resistance when expressed in Streptococcus sanguis Challis.
Nucleotide sequence analysis of tetracycline resistance gene tetO from Streptococcus mutans DL5.
Nucleotide sequence analysis of tetracycline resistance gene tetO from Streptococcus mutans DL5.
Analysis of newly detected tetracycline resistance genes and their flanking sequences in human intestinal bifidobacteria.
The study identified tet(W), tet(O), and tet(S) as tetracycline resistance genes in human intestinal bifidobacteria, highlighting their potential as reservoirs of resistance genes.
Transcriptional Response of Resistome to Composting and Its Implications for Antimicrobial Resistance Dissemination
The study identifies several tetracycline resistance genes (tetM, tetW, tetO, tetS), sulfonamide resistance genes (sulI, sulII), and others, showing their expression dynamics during composting and their association with microbial community shifts.
Association between selected antimicrobial resistance genes and antimicrobial exposure in Danish pig farms.
The study identified several antimicrobial resistance (AMR) genes, including ermB, ermF, sulI, sulII, tet(M), tet(O), and tet(W), and examined their association with antimicrobial exposure in Danish pig farms. The results showed complex relationships between antimicrobial exposure and AMR gene levels, with varying correlations depending on the specific gene and antimicrobial class.
ICESag37, a Novel Integrative and Conjugative Element Carrying Antimicrobial Resistance Genes and Potential Virulence Factors in Streptococcus agalactiae.
The study characterizes ICE Sag37, a novel integrative and conjugative element carrying multiple antimicrobial resistance genes, including erm(B), tet(O), aadE, aphA, and ant(6), in Streptococcus agalactiae.
Characterization of Streptococcus pyogenes from Animal Clinical Specimens, Spain.
The study characterizes 15 Streptococcus pyogenes isolates from animals in Spain, identifying macrolide resistance genes mef A and erm B, and tetracycline resistance genes tet M and tet O. Most isolates exhibited the M phenotype for macrolide resistance, while some showed cMLS B or iMLS B phenotypes.
The Obscure World of Integrative and Mobilizable Elements, Highly Widespread Elements that Pirate Bacterial Conjugative Systems.
The paper discusses the role of integrative and mobilizable elements (IMEs) in bacterial evolution, focusing on their ability to hijack conjugative systems for their transfer and their potential to carry antibiotic resistance genes.
Genomic comparisons of Streptococcus suis serotype 9 strains recovered from diseased pigs in Spain and Canada.
The study identified multiple tetracycline, macrolide, lincosamide, and aminoglycoside resistance genes in Streptococcus suis serotype 9 strains, highlighting the widespread presence of antibiotic resistance mechanisms in these isolates.
Subtype-Specific Selection for Resistance to Fluoroquinolones but Not to Tetracyclines Is Evident in Campylobacter jejuni Isolates from Beef Cattle in Confined Feeding Operations in Southern Alberta, Canada.
The study identifies tetO as the primary tetracycline resistance gene in Campylobacter jejuni isolates from beef cattle and highlights gyrA mutations, particularly Thr86Ile, as a major cause of fluoroquinolone resistance.
High diversity and abundance of cultivable tetracycline-resistant bacteria in soil following pig manure application.
The study identifies several tetracycline resistance genes (tet B, tet L, tet Z, tet M, tet O, and tet X) in cultivable tetracycline-resistant bacteria from pig manure and soil, highlighting the diversity and abundance of these genes following pig manure application.
Comparison of antimicrobial resistance genes in feedlots and urban wastewater.
The study identified various antimicrobial resistance genes in feedlots and urban wastewater, highlighting the prevalence of sulfonamide, tetracycline, macrolide, fluoroquinolone, and β-lactam resistance genes in different environments.
Antibiotic residues in liquid manure from swine feedlot and their effects on nearby groundwater in regions of North China.
The study identified antibiotic resistance genes (ARGs) such as qnrA, sulI, sulII, tetG, tetM, tetO, and intI1 in liquid manure from swine feedlots and their effects on nearby groundwater. These genes were found to be associated with fluoroquinolone, sulfonamide, and tetracycline resistance.
Antimicrobial Resistance in Streptococcus spp.
The paper discusses the prevalence and mechanisms of antimicrobial resistance in Streptococcus species, particularly focusing on macrolide, lincosamide, and tetracycline resistance. Key genes identified include erm(B), erm(A), lnuB, lnuD, mefA, mefE, msr, tet(B), tet(K), tet(L), tet(M), tet(O), and tet(S).
Various Profiles of tet Genes Addition to tet(X) in Riemerella anatipestifer Isolates From Ducks in China.
The study identified and characterized multiple tetracycline resistance genes, including tet(A), tet(B), tet(M), tet(O), tet(O/W/32/O), tet(Q), and tet(X), in Riemerella anatipestifer isolates from ducks in China. The tet(X) gene was found to be the primary mechanism of tetracycline resistance.
Increasing macrolide resistance among Streptococcus agalactiae causing invasive disease in non-pregnant adults was driven by a single capsular-transformed lineage, Portugal, 2009 to 2015.
The study identifies a significant increase in macrolide resistance among Streptococcus agalactiae isolates causing invasive disease in non-pregnant adults in Portugal, primarily linked to the expansion of a specific capsular-transformed lineage (CC1) harboring resistance genes such as erm(B), erm(TR), erm(T), mef(E), tet(M), tet(O), and tet(L).
Combination Therapy Strategies Against Multiple-Resistant Streptococcus Suis.
The study identifies several AMR genes in multidrug-resistant Streptococcus suis isolates, including tetM, lnuB, erm(B), tetO, tetL, and aph3′, which confer resistance to tetracycline, clindamycin, erythromycin, and aminoglycosides.
The draft genomes and investigation of serotype distribution, antimicrobial resistance of group B Streptococcus strains isolated from urine in Suzhou, China.
The study identified several AMR genes in GBS isolates from urine in Suzhou, including tetM, ermB, mefE, lnuB, and others, associated with resistance to tetracycline, erythromycin, clindamycin, and fluoroquinolones.
Human Campylobacteriosis in Italy: Emergence of Multi-Drug Resistance to Ciprofloxacin, Tetracycline, and Erythromycin.
The study identified the tet(O) gene as a determinant of tetracycline resistance in Campylobacter spp. and characterized mutations in the gyrA gene associated with ciprofloxacin resistance.
Novel virulence, antibiotic resistance and toxin gene-specific PCR-based assays for rapid pathogenicity assessment of Arcobacter faecis and Arcobacter lanthieri.
The study identified and characterized the tet(O) and tet(W) genes in Arcobacter faecis and Arcobacter lanthieri, which confer resistance to tetracycline.
Phenotypic and Genotypic Examination of Antimicrobial Resistance in Thermophilic Campylobacter Species Isolated from Poultry in Turkey.
ICESsuHN105, a Novel Multiple Antibiotic Resistant ICE in Streptococcus suis Serotype 5 Strain HN105.
The study identifies a novel integrative conjugative element (ICE), ICESsuHN105, carrying multiple antibiotic resistance genes in Streptococcus suis serotype 5 strain HN105, contributing to its multidrug resistance phenotype.
Phylogenetic Diversity and Antimicrobial Resistance of Campylobacter coli from Humans and Animals in Japan.
Biofilm Forming Antibiotic Resistant Gram-Positive Pathogens Isolated From Surfaces on the International Space Station.
The study identified several AMR genes including ermC, tetK, aac6-aph2a, aph(2)-ic, aadD, aph3-III, and ermB in Gram-positive pathogens isolated from the International Space Station. These genes conferred resistance to erythromycin, tetracycline, gentamicin, kanamycin, and other antibiotics.
Antimicrobial resistance profiles of vancomycin-resistant Enterococcus species isolated from laboratory mice.
The study identified tet(O) and tet(S) genes in tetracycline-resistant Enterococcus gallinarum isolates from laboratory mice, indicating horizontal gene transfer potential.
Independent Microevolution Mediated by Mobile Genetic Elements of Individual Clostridium difficile Isolates from Clade 4 Revealed by Whole-Genome Sequencing.
The study identified multiple antimicrobial resistance genes, including aac(6')-Ib, ermB, tetM, and catD, in Clostridium difficile isolates from clade 4, highlighting the role of mobile genetic elements in the evolution of multidrug resistance.
Characterization and Phylogenetic Analysis of Campylobacter Species Isolated from Paediatric Stool and Water Samples in the Northwest Province, South Africa.
The study identified the tetO gene, 23S rRNA 2075G/2074C mutation, and gryA gene as major contributors to antibiotic resistance in Campylobacter isolates from pediatric stool and water samples in South Africa.
Campylobacter species prevalence, characterisation of antimicrobial resistance and analysis of whole-genome sequence of isolates from livestock and humans, Latvia, 2008 to 2016.
The study identified quinolone resistance mediated by gyrA Thr-86-Ile mutation, tetracycline resistance via tet(O) gene, aminoglycoside resistance through ant(6)-Ib and APH(3')-IIIa genes, and multidrug resistance via cmeABC efflux pump in Campylobacter isolates from Latvia.
Comparative diversity of microbiomes and Resistomes in beef feedlots, downstream environments and urban sewage influent.
The study identified several tetracycline, macrolide, aminoglycoside, beta-lactam, sulfonamide, mercury, and biocide resistance genes in beef feedlots, catch basin water, soil, and urban sewage influent. Tetracycline resistance was predominant in beef production systems, while urban sewage influent showed a diverse resistome with resistance to multiple antimicrobial classes.
Microbiological and clinical characteristics of Streptococcus gallolyticus subsp. pasteurianus infection in China.
The study characterizes the AMR genes and mutations in Streptococcus gallolyticus subsp. pasteurianus isolates from China, identifying erm(B), erm(A), erm(T), mef(A/E), tet(L), tet(O), and tet(M) as major contributors to erythromycin, clindamycin, and tetracycline resistance.
The fecal resistome of dairy cattle is associated with diet during nursing.
The study identified various antimicrobial resistance genes (ARGs) in the fecal microbiota of dairy calves, highlighting the association between diet and the resistome. Key genes include ermB, lnuC, mefA, tet32, tet40, tetO, tetQ, tetW, and optrA, which confer resistance to macrolides, lincosamides, streptogramin B, and tetracyclines, as well as oxazolidinones and phenicols.
Comparative genomic analyses reveal diverse virulence factors and antimicrobial resistance mechanisms in clinical Elizabethkingia meningoseptica strains.
The study identified multiple antimicrobial resistance genes in Elizabethkingia meningoseptica strains, including beta-lactamases, tetracycline resistance genes, and efflux pumps, indicating a multidrug-resistant profile.
Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry.
The study identified tetracycline resistance gene tet(O), beta-lactam resistance genes blaOXA-61 and blaOXA-184, and the CmeABC efflux pump system as major contributors to antimicrobial resistance in Campylobacter jejuni isolates from Italy.
International Spread of Multidrug-Resistant Campylobacter coli in Men Who Have Sex With Men in Washington State and Quebec, 2015-2018.
Genotypic diversity of Streptococcus suis and the S. suis -like bacterium Streptococcus ruminantium in ruminants.
The study identified several antibiotic resistance genes in Streptococcus ruminantium isolates, including genes conferring resistance to tetracycline, streptomycin, erythromycin, kanamycin, and chloramphenicol. These genes were located in genomic islands and showed similarities to integrative conjugative elements.
Investigation of molecular mechanisms underlying tetracycline resistance in thermophilic Campylobacter spp. suggests that previous reports of tet(A)-mediated resistance in these bacteria are premature.
The study found that 100% of tetracycline-resistant Campylobacter isolates harbored the tet(O) gene, suggesting that previous reports of tet(A) in these bacteria may have been due to misidentification.
Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014-2016.
The study identifies the tetO gene as a key factor in tetracycline resistance in Campylobacter jejuni ST6964, which emerged in New Zealand in 2014. Additionally, the C257T (Thr86Ile) mutation in the gyrA gene was found to be responsible for fluoroquinolone resistance in this strain.
Resistome metagenomics from plate to farm: The resistome and microbial composition during food waste feeding and composting on a Vermont poultry farm.
The study identified 50 unique antibiotic resistance genes (ARGs) in food waste, compost, and farm products, with a focus on aminoglycoside, tetracycline, and macrolide resistance. Key ARGs included aph(6)-1d, lmrD, mefA, mel, abeM, abeS, adeF, adeG, adeI, adeJ, adeK, emrD, sul2, tetH, tetM, tetO, tetW, and tetX, which were found in various samples and showed resistance to multiple drug classes.
Unexpected relationships between frequency of antimicrobial resistance, disease phenotype and emm type in group A Streptococcus.
The study identifies specific AMR genes such as tet(M), erm(B), mef(A), msr(D), tet(O), erm(A), ant(6)-Ia, aph(3')-III, and erm(T) associated with resistance to tetracycline, erythromycin, clindamycin, and aminoglycosides in group A Streptococcus (GAS) strains. These genes are linked to high-frequency resistance in certain emm types, particularly emm11, emm75, emm77, and emm92, which are overrepresented in invasive GAS infections.
Tetracycline Resistant Campylobacter jejuni Subtypes Emanating from Beef Cattle Administered Non-Therapeutic Chlortetracycline are Longitudinally Transmitted within the Production Continuum but are Not Detected in Ground Beef.
The study found that tetracycline resistance in Campylobacter jejuni is primarily mediated by the tetO gene, and that AS700 administration increased the carriage of tetO and tetW resistance determinants in the fecal bacterial community of beef cattle.
Antimicrobial resistance patterns and molecular resistance markers of Campylobacter jejuni isolates from human diarrheal cases.
The study identified the tet(O) gene as a determinant of tetracycline resistance, the C257T mutation in gyrA as a cause of quinolone resistance, and the A2075G mutation in the 23S rRNA gene as a factor in erythromycin resistance in Campylobacter jejuni isolates.
Antimicrobial Resistance in Clostridium and Brachyspira spp. and Other Anaerobes.
The paper describes the antimicrobial resistance mechanisms in Clostridium and Brachyspira spp. and other anaerobes, focusing on the genetic basis of resistance to various antibiotics, including tetracyclines, macrolides, lincosamides, chloramphenicol, and others. It highlights the role of specific genes such as tet, erm, and cat in conferring resistance.
Characterisation of Campylobacter spp. Isolated from Poultry in KwaZulu-Natal, South Africa.
The study identified the gyrA mutation (Thr-86-Ile), tet(O) gene, and cmeB gene as contributors to antibiotic resistance in Campylobacter spp. isolates from poultry in KwaZulu-Natal, South Africa.
Prevalence and genomic characteristics of zoonotic gastro-intestinal pathogens and ESBL/pAmpC producing Enterobacteriaceae among Swedish corvid birds.
The study identified blaCTX-M-55, a gene conferring resistance to extended-spectrum cephalosporins, in an E. coli isolate from a corvid bird. Additionally, the tetracycline resistance gene tetO was found in multiple C. jejuni isolates.
Functional metagenomics reveals antibiotic resistance determinants in dairy-associated microbial communities
The study identified several antibiotic resistance (AR) determinants in dairy products and processing environments, including genes conferring resistance to beta-lactams, tetracyclines, glycopeptides, macrolides, and streptogramins. Notably, Lactococcus lactis was found to be a significant reservoir of multidrug-resistant genes.
Metagenomic analysis reveals the microbiome and resistome in migratory birds.
The study identifies numerous antibiotic resistance genes (ARGs) in migratory birds, highlighting the presence of mcr-1, beta-lactamases, tetracycline resistance genes, and other resistance mechanisms. These findings suggest that migratory birds could serve as reservoirs and potential vectors for spreading ARGs into the environment.
Investigation of a Reduction in Tylosin on the Prevalence of Liver Abscesses and Antimicrobial Resistance in Enterococci in Feedlot Cattle.
The study identified several AMR genes in enterococci isolated from feedlot cattle, including erm(B), msr(C), tet(L), tet(M), and tet(O), which confer resistance to macrolides and tetracyclines.
Genomic Epidemiology and Evolution of Diverse Lineages of Clinical Campylobacter jejuni Cocirculating in New Hampshire, USA, 2017.
The study identified multiple horizontally acquired resistance genes in Campylobacter jejuni isolates from New Hampshire, including genes conferring resistance to beta-lactams, aminoglycosides, streptothricin, and tetracycline.
Identification of Selected Antibiotic Resistance Genes in Two Different Wastewater Treatment Plant Systems in Poland: A Preliminary Study.
The study identified the presence of tetracycline resistance genes (tet(B), tet(K), tet(L), tet(O)) and the sulfonamide resistance gene sulIII in wastewater treatment plant samples. These genes were detected in both raw influent and final effluent samples, indicating their persistence through the treatment process.
Isolation and Comparative Genomic Analysis of Reuterin-Producing Lactobacillus reuteri From the Chicken Gastrointestinal Tract.
The study identified ermB and tetW genes in L. reuteri strains from chicken GIT, which confer resistance to erythromycin and tetracycline, respectively. These genes were validated through PCR and sequencing.
Comparison of Molecular Subtyping and Antimicrobial Resistance Detection Methods Used in a Large Multistate Outbreak of Extensively Drug-Resistant Campylobacter jejuni Infections Linked to Pet Store Puppies.
The study identified multiple antimicrobial resistance genes and mutations in Campylobacter jejuni isolates from a large multistate outbreak linked to pet store puppies, including resistance to tetracycline, aminoglycosides, macrolides, fluoroquinolones, and others.
Molecular subtyping and antimicrobial susceptibility of Streptococcus dysgalactiae subspecies equisimilis isolates from clinically diseased pigs.
The study identified macrolide resistance genes erm(B) and mef(A/E), tetracycline resistance genes tet(M) and tet(O), and two mutations in parC associated with fluoroquinolone resistance in SDSE isolates from pigs.
Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study.
The study identified 55 different antimicrobial resistance determinants in diarrheal pathogens, highlighting the presence of genes conferring resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, macrolides, tetracyclines, phenicols, sulfonamides, and others. Notably, carbapenemase genes like bla OXA-48 and bla NDM were detected in certain isolates, indicating emerging resistance concerns.
Antimicrobial Resistance and Virulence-Associated Markers in Campylobacter Strains From Diarrheic and Non-diarrheic Humans in Poland.
The study identified several AMR genes, including blaOXA61, blaOXA184, tet(O), tet(O/32/O), aadE-Cc, and aph(3')-III, which confer resistance to beta-lactams, tetracyclines, and aminoglycosides in Campylobacter isolates. Additionally, mutations in the cmeR gene were linked to increased resistance to erythromycin, fluoroquinolones, and macrolides.
Antimicrobial Resistance Gene Detection and Plasmid Typing Among Multidrug Resistant Enterococci Isolated from Freshwater Environment.
The study identified twelve antimicrobial resistance genes in multidrug-resistant Enterococcus isolates from freshwater, including genes conferring resistance to tetracycline, erythromycin, tylosin, kanamycin, streptomycin, and ciprofloxacin. These genes were detected through PCR and sequencing, highlighting the diversity of resistance mechanisms in environmental Enterococcus.
WGS-Based Prediction and Analysis of Antimicrobial Resistance in Campylobacter jejuni Isolates From Israel.
The study identified several AMR genes and mutations in Campylobacter jejuni isolates from Israel, including the tet(O) gene for tetracycline resistance, the gyrA T86I mutation for quinolone resistance, the aadE gene for streptomycin resistance, and various bla OXA genes for beta-lactam resistance. The cmeABC multidrug efflux transporter was also found to be prevalent.
Benchmarking hybrid assembly approaches for genomic analyses of bacterial pathogens using Illumina and Oxford Nanopore sequencing.
The study compared hybrid assembly approaches for bacterial pathogen genomes and identified AMR genes such as blaZ, msr(A), and tet(K) in Staphylococcus aureus.
Prediction of antimicrobial resistance in clinical Campylobacter jejuni isolates from whole-genome sequencing data.
The study identified seven resistance genes and several mutations associated with antimicrobial resistance in Campylobacter jejuni isolates, demonstrating the effectiveness of whole-genome sequencing in predicting resistance.
Pyrolyzed biowastes deactivated potentially toxic metals and eliminated antibiotic resistant genes for healthy vegetable production.
The study found that pyrolysis of biowastes effectively reduced the abundance of antibiotic resistance genes (ARGs) such as tetracycline resistance genes (tetC, tetG, tetM, tetO, tetW), sulfonamide resistance genes (sul1, sul2), and class 1 integron-integrase gene (intI1) in swine manure and sewage sludge.
Sewer biofilm microbiome and antibiotic resistance genes as function of pipe material, source of microbes, and disinfection: field and laboratory studies.
This study identified various antibiotic resistance genes (ARGs) in sewer biofilms, including sul1, blaTEM, tet(G), tet(O), tet(W), and ermF, which were detected in field and simulated sewer biofilm samples. The research also explored the effects of disinfection protocols on biofilm persistence.
Genomic Analysis Reveals the Genetic Determinants Associated With Antibiotic Resistance in the Zoonotic Pathogen Campylobacter spp. Distributed Globally.
The study identified 15 acquired genes associated with resistance to five distinct antibiotic classes in Campylobacter spp., including novel beta-lactamase genes blaOXA-493 and blaOXA-576, and characterized mutations in gyrA, rpsL, and 23S rRNA that confer resistance to fluoroquinolones, streptomycin, and macrolides, respectively.
Characterization of Campylobacter associated gastric enteritis among patients with Human Immunodeficiency Virus (HIV) in a hospital in Accra, Ghana.
The study identified Campylobacter coli isolates resistant to multiple antibiotics, including tetracycline, ciprofloxacin, and erythromycin, with the presence of resistance genes bla OXA-61, cme B, tet (O), and aad E.
Genotyping and Antibiotic Resistance Traits in Campylobacter jejuni and coli From Pigs and Wild Boars in Italy.
The study identified various AMR genes and mutations in Campylobacter isolates from pigs and wild boars in Italy, highlighting high levels of resistance to tetracycline, ciprofloxacin, nalidixic acid, and erythromycin. Key findings include the detection of tet(O), cmeA, cmeB, cmeC, cmeR, OXA-61, and aph(3')-III genes, as well as the gyrA T86I mutation and 23S rRNA A2075G mutation.
Susceptibility of Campylobacter Strains to Selected Natural Products and Frontline Antibiotics.
The study identified mutations in the gyrA and tet(O) genes in Campylobacter strains, which conferred resistance to quinolones and tetracycline, respectively. Natural products showed efficacy against both susceptible and resistant strains.
Antibiotic Resistance Profiles and Molecular Mechanisms of Campylobacter From Chicken and Pig in China.
The study identified the gyrA C257T mutation, tetO gene, and ermB gene as key contributors to fluoroquinolone, tetracycline, and macrolide resistance in Campylobacter isolates from chickens and pigs in China.
Features of Streptococcus agalactiae strains recovered from pregnant women and newborns attending different hospitals in Ethiopia.
The study identified tetracycline resistance genes tetM, tetL, and tetO, macrolide/lincosamide resistance genes ermTR, ermB, and lnu, and aminoglycoside resistance gene aac(6')-Ib in Streptococcus agalactiae isolates. Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
Distribution of Antibiotic-Resistant Enterobacteriaceae Pathogens in Potable Spring Water of Eastern Indian Himalayas: Emphasis on Virulence Gene and Antibiotic Resistance Genes in Escherichia coli.
The study identified antibiotic resistance genes CITM, aadA1, tetO, and qnrB in Escherichia coli isolates from spring water in Sikkim, indicating the presence of multidrug-resistant Enterobacteriaceae.
Population genomics and antimicrobial resistance in Corynebacterium diphtheriae.
The study identifies several AMR genes in Corynebacterium diphtheriae, including pbp2m associated with penicillin resistance, ermX for macrolide resistance, and various genes for tetracycline, aminoglycoside, and sulfonamide resistance.
Research Note: Antimicrobial resistance of Campylobacter species isolated from chickens near Ulaanbaatar city, Mongolia.
The study identified tetracycline resistance mediated by the tet(O) gene and erythromycin resistance via the erm(B) gene and a nucleotide substitution at nt 2,075 of 23S rDNA in Campylobacter isolates from Mongolian chickens. Fluoroquinolone resistance was linked to a single-nucleotide substitution at codon 86 of the gyrA gene.
The distribution of antibiotic resistance genes in chicken gut microbiota commensals.
The study identified various tetracycline resistance genes including tet(W), tet(Q), tet(32), tet(O), tet(44), tetA(P), and tetB(P) in chicken gut microbiota commensals, highlighting their distribution across different bacterial families.
Epidemiological analysis of pneumococcal strains isolated at Yangon Children's Hospital in Myanmar via whole-genome sequencing-based methods.
The study identified multiple AMR genes and mutations in pneumococcal strains from Myanmar, including genes conferring resistance to azithromycin, tetracycline, chloramphenicol, and quinolones, as well as mutations in penicillin-binding proteins and DNA gyrase. These findings highlight the spread of AMR in pneumococcal strains in Myanmar.
Antimicrobial resistance and interspecies gene transfer in Campylobacter coli and Campylobacter jejuni isolated from food animals, poultry processing, and retail meat in North Carolina, 2018-2019.
The study identified various AMR genes and mutations in Campylobacter isolates from food animals, poultry processing, and retail meat in North Carolina, highlighting the prevalence of tetracycline, quinolone, and aminoglycoside resistance. Key findings include the detection of tet(O), gyrA(T86I), and multiple aminoglycoside resistance genes such as aad9, aadE-Cc, aph(2')-If, and aph(3')-IIIa.
SWINE VIRULENCE ASSESSMENT
This study analyzed the virulence and genomic characteristics of nine United States Streptococcus suis isolates, identifying genomic attributes associated with swine-virulent phenotypes. However, no specific AMR genes or mutations were experimentally validated in this paper.
Genomic analysis of the diversity, antimicrobial resistance and virulence potential of clinical Campylobacter jejuni and Campylobacter coli strains from Chile.
The study identified blaOXA-61, cmeABC, and tetO as key antimicrobial resistance genes in Campylobacter jejuni and Campylobacter coli strains from Chile, along with a gyrA mutation (C257T) associated with fluoroquinolone resistance.
Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins.
The study identifies several ribosomal protection protein (RPP) genes, including tet(M), tet(O), tet(W), tet(Q), tetB(P), and otr(A), that can confer high-level tetracycline resistance in E. coli. However, expression of these genes often comes with fitness costs, and certain mutations in tRNA genes (argW and proL) or the hns gene can mitigate these costs.
Complete Genome Analysis of Campylobacter jejuni subsp. jejuni Isolated from Bloodstream Infection.
The study reports the identification of antimicrobial resistance determinants in a clinical Campylobacter jejuni strain, including blaOXA-450 for beta-lactams, tet(O) for tetracycline, and a gyrA T86I mutation for fluoroquinolones.
Occurrence and Antimicrobial Resistance of Arcobacter spp. Recovered from Aquatic Environments.
The study identified tetracycline resistance genes tetO and tetW in Arcobacter butzleri isolates, highlighting the presence of multidrug-resistant Arcobacter strains in aquatic environments.
Antimicrobial Resistance Profiles, Virulence Genes, and Genetic Diversity of Thermophilic Campylobacter Species Isolated From a Layer Poultry Farm in Korea.
High-level resistance to ciprofloxacin, nalidixic acid, and tetracycline was observed in Campylobacter jejuni and Campylobacter coli isolates. A missense mutation (C257T) in the gyrA gene was confirmed, and the tet(O) gene was identified as a determinant of tetracycline resistance.
Whole genome-based characterisation of antimicrobial resistance and genetic diversity in Campylobacter jejuni and Campylobacter coli from ruminants.
The study identified various AMR genes including aminoglycoside-modifying enzymes, tetracycline resistance genes, and beta-lactamases in Campylobacter jejuni and C. coli isolates from ruminants. Mutations in gyrA and rpsL were linked to quinolone and streptomycin resistance, respectively. The presence of specific genetic determinants correlated with phenotypic resistance.
Whole genome-based characterisation of antimicrobial resistance and genetic diversity in Campylobacter jejuni and Campylobacter coli from ruminants.
The study identified various AMR genes including aminoglycoside-modifying enzymes, tetracycline resistance genes, and beta-lactamases in Campylobacter jejuni and C. coli isolates from ruminants. Mutations in gyrA and rpsL were linked to quinolone and streptomycin resistance, respectively. The presence of specific genetic determinants correlated with phenotypic resistance.
Occurrence, Antimicrobial Resistance, and Molecular Characterization of Campylobacter spp. in Intensive Pig Production in South Africa.
The study identified tetracycline resistance gene tetO, ampicillin resistance gene blaOXA-61, and multidrug efflux pump gene cmeB in Campylobacter spp. Additionally, mutations in gyrA (Thr-86-Ile) and 23S rRNA (A2075G and A2074C) were found to confer resistance to quinolones and erythromycin, respectively.
Multidrug Resistance and Molecular Characterization of Streptococcus agalactiae Isolates From Dairy Cattle With Mastitis.
The study identified several AMR genes in S. agalactiae isolates from dairy cattle with mastitis, including tet(O), ermB, lnu(B), and aphA3, which confer resistance to tetracycline, erythromycin, clindamycin, pirlimycin, and kanamycin.
Emergence of Invasive Serotype Ib Sequence Type 10 Group B Streptococcus Disease in Chinese Infants Is Driven by a Tetracycline-Sensitive Clone.
The study identifies the emergence of invasive serotype Ib sequence type 10 Group B Streptococcus (GBS) disease in Chinese infants, highlighting the presence of multiple resistance mechanisms including ermB, mefA, lnuB, tetM, and tetO genes, along with fluoroquinolone resistance mediated by mutations in gyrA and parC.
Mitigating Antibiotic Resistance Genes in Wastewater by Sequential Treatment with Novel Nanomaterials.
The study demonstrates the effectiveness of novel nanomaterials in reducing antibiotic resistance genes (ARGs) in wastewater, including bla CTXM, erm B, qnr S, sul 1, tet O, mec A, van A, and intI 1.
Ribosome Protection Proteins-'New' Players in the Global Arms Race with Antibiotic-Resistant Pathogens.
The paper discusses ribosome protection proteins (RPPs) as significant contributors to antibiotic resistance, particularly against tetracyclines, fusidic acid, and various other antibiotics targeting the ribosome. Key RPPs include TetM, TetO, FusB, VgaA, LsaA, MsrE, MsrA, optrA, and poxtA, which confer resistance through mechanisms involving direct interaction with the ribosome and displacement of antibiotics.
High-throughput sequencing reveals genetic determinants associated with antibiotic resistance in Campylobacter spp. from farm-to-fork.
The study identified several AMR genes and mutations associated with resistance to quinolones, tetracyclines, and macrolides in Campylobacter isolates from various sources. Key findings include the prevalence of blaOXA-61, tet(O), and mutations in gyrA and 23S rRNA genes.
Highly Prevalent Multidrug-Resistant Campylobacter spp. Isolated From a Yellow-Feathered Broiler Slaughterhouse in South China.
The study identified multiple AMR genes and mutations in Campylobacter spp. isolated from a yellow-feathered broiler slaughterhouse, highlighting high levels of multidrug resistance.
Factors associated with elevated levels of antibiotic resistance genes in sewer sediments and wastewater.
The study identified several antibiotic resistance genes (ARGs) in sewer sediments and wastewater, including sul1, tet(O), tet(W), ermF, vanA, NDM-1, mcr-1, and mecA, highlighting the potential for ARG proliferation in sewer environments.
Genomic Characterization of Fluoroquinolone-Resistant Thermophilic Campylobacter Strains Isolated from Layer Chicken Feces in Gangneung, South Korea by Whole-Genome Sequencing.
The study identified fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli strains through the C257T mutation in the gyrA gene and the cmeABC efflux pump. Tetracycline resistance was associated with the tet(O) gene. Beta-lactam resistance was indicated by blaOXA-452, blaOXA-521, and blaOXA-193 genes.
Exploring the Genomic Diversity and Antimicrobial Susceptibility of Bifidobacterium pseudocatenulatum in a Vietnamese Population.
The study identified ermX and tetO genes in Bifidobacterium pseudocatenulatum isolates from Vietnam, which confer resistance to azithromycin and tetracycline, respectively. Additionally, mutations in the gyrA gene were associated with ciprofloxacin resistance.
Ongoing Outbreak of Extensively Drug-Resistant Campylobacter jejuni Infections Associated With US Pet Store Puppies, 2016-2020.
Extensively drug-resistant Campylobacter jejuni strains were found to be associated with pet store puppies, showing resistance to multiple antibiotic classes including fluoroquinolones, macrolides, and tetracyclines.
Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection.
Nine Clostridioides difficile strains isolated from Korean patients were analyzed, revealing diverse antibiotic resistance genes including those conferring resistance to erythromycin, clindamycin, glycopeptides, fluoroquinolones, aminoglycosides, and tetracyclines.
Genomic and pathogenic investigations of Streptococcus suis serotype 7 population derived from a human patient and pigs.
The study identified several AMR genes in Streptococcus suis serotype 7 strains, including tetracycline resistance genes (tet(O), tet(M), tet(W)), macrolide/lincosamide/streptogramin resistance gene (erm(B)), aminoglycoside resistance genes (ant(6)-Ia, aph(3')-IIIa, aac(6')-Ie-aph(2'')-Ia), trimethoprim resistance gene (dfrF), and chloramphenicol resistance gene (cat-TC).
Natural Horizontal Gene Transfer of Antimicrobial Resistance Genes in Campylobacter spp. From Turkeys and Swine.
The study identified the horizontal transfer of antimicrobial resistance genes, including blaOXA, aph(2''')-If, aadE-Cc, and tet(O), in Campylobacter spp. from turkeys and swine, demonstrating the potential for resistance gene dissemination between different Campylobacter species and hosts.
Genomic Characterisation of Campylobacter jejuni Isolates Recovered During Commercial Broiler Production.
The study identified tetracycline resistance gene tetO, fluoroquinolone resistance mutation gyrA T86I, beta-lactamase genes bla OXA-61 and bla OXA-184, and multidrug efflux pump genes cmeABC and cmeR in Campylobacter jejuni isolates from broiler production.
Resistome Analysis in the Digestive Tract of Food-Producing Animals
The study identifies tetW and mefA as highly expressed tetracycline and macrolide resistance genes in the rumen of beef cattle, highlighting their significance in the resistome of food-producing animals.
Impact of Antibiotic Therapies on Resistance Genes Dynamic and Composition of the Animal Gut Microbiota.
The study examined the impact of antibiotic therapies on the dynamics and composition of resistance genes in the animal gut microbiota, identifying several AMR genes such as blaTEM, tetA, strA, strB, intI1, tetM, mel, floR, mcr-2, oqx B, tetC, tetG, tetO, tetW, tetX, ermB, ermF, sul1, sul2, and others, which were experimentally validated in Escherichia coli.
Molecular Typing and Antimicrobial Susceptibility Profiles of Streptococcus uberis Isolated from Sheep Milk.
The study identified resistance genes ermB, ermC, blaZ, tetM, tetO, and tetK in Streptococcus uberis isolates from sheep milk, contributing to resistance against erythromycin, penicillin, and tetracycline.
Occurrence and spread of antibiotic-resistant bacteria on animal farms and in their vicinity in Poland and Ukraine-review.
The review highlights the presence of antibiotic-resistant bacteria and resistance genes in the environments of animal farms in Poland and Ukraine, emphasizing the spread of multidrug-resistant strains such as MRSA and Salmonella. Key resistance genes identified include blaTEM, blaPSE, floR, tetA, tetB, tetC, tetG, cat1, dfrA1, dfrA5, dfrA7, dfrA12, dfrA17, sul1, sul2, sul3, ermB, tetL, tetW, tetM, blaZ, mecA, qnrS1, qnrS3, qnrB10, qnrB19, blaCTX-M-25, and blaOXA-21.
New Sequence Types and Antimicrobial Drug-Resistant Strains of Streptococcus suis in Diseased Pigs, Italy, 2017-2019.
The study identified several AMR genes in Streptococcus suis isolates from diseased pigs in Italy, including ermb, tet(O), aac6-aph2, ant6-ia, aph3-iiia, spw, tet(40), tet(W), tet(O/W/32/O), tet(W/N/N), erm(47), lnuB, lsaE, and optrA, which confer resistance to various antibiotics such as erythromycin, tetracycline, gentamicin, lincomycin, and linezolid.
Prevalence and Antimicrobial Resistance Profiles of Foodborne Pathogens Isolated from Dairy Cattle and Poultry Manure Amended Farms in Northeastern Ohio, the United States.
The study identified several antimicrobial resistance genes in foodborne pathogens isolated from dairy cattle and poultry manure amended farms in Northeastern Ohio, including mphA, aadA, aphA1, tetA, aac(3)-IV, sulII, blaTEM, tetB, strA, aac(3)-Iva, ampC, lde, ermB, tet(O), aadB, penA, blaOXA-61, aadE, and aph-3-1.
Invasive Group B Streptococcal Disease in Neonates and Infants, Italy, Years 2015-2019.
The study identified the presence of ermB, tetO, and tetM genes in Streptococcus agalactiae strains, which conferred resistance to erythromycin, clindamycin, and tetracycline, respectively. The MDR CC-17 sub-clone was associated with increased resistance rates.
Differences in Genotype and Antimicrobial Resistance between Campylobacter spp. Isolated from Organic and Conventionally Produced Chickens in Sweden.
The study identified quinolone resistance in Campylobacter jejuni isolates from conventional chickens, primarily due to the T86I mutation in the gyrA gene, and tetracycline resistance associated with the tet(O) gene.
Emerging Fatal Ib/CC12 Hypervirulent Multiresistant Streptococcus agalactiae in Young Infants With Bloodstream Infection in China.
The study identifies multiple antibiotic resistance genes in Ib/CC12 Streptococcus agalactiae strains, including genes conferring resistance to macrolides, clindamycin, aminoglycosides, tetracycline, and other antibiotics.
Outbreak of Multidrug-Resistant Salmonella Heidelberg Infections Linked to Dairy Calf Exposure, United States, 2015-2018.
The study identifies a multidrug-resistant (MDR) Salmonella Heidelberg outbreak linked to dairy calf exposure, highlighting the presence of plasmid-borne resistance genes such as aadA1, aph(3')-Ia, bla CMY-2, floR, fosA7, qnrB19, strA, strB, sull, sul2, tet(A), tet(B), tet(O), and a novel gene dfrA34.
Genomic Characterization of Streptococcus suis Serotype 24 Clonal Complex 221/234 From Human Patients.
The study identified tet(O) and erm(B) genes in three Streptococcus suis serotype 24 CC221/234 strains, which confer resistance to tetracycline, erythromycin, and clindamycin.
Methicillin-Resistant Staphylococcus aureus from Peninsular Malaysian Animal Handlers: Molecular Profile, Antimicrobial Resistance, Immune Evasion Cluster and Genotypic Categorization.
The study identified tetracycline resistance genes (tetK, tetL, tetM) and erythromycin resistance genes (ermA, ermB, ermC, msrA) in S. aureus isolates from Peninsular Malaysian animal handlers.
Multidrug-Resistant Methicillin-Resistant Coagulase-Negative Staphylococci in Healthy Poultry Slaughtered for Human Consumption.
The study identified multiple multidrug-resistant methicillin-resistant coagulase-negative staphylococci (MRCoNS) in poultry, carrying genes such as mecA, ermA, ermB, ermC, mphC, aph(3')-IIIa, ant(4')-Ia, str, tetK, tetL, tetM, tetO, cfr, dfrK, dfrD, and cat p194, which confer resistance to various antibiotics.
Invited Review: Antimicrobial Use and Antimicrobial Resistance in Pathogens Associated with Diarrhea and Pneumonia in Dairy Calves.
The review identified several AMR genes in pathogens associated with calf diarrhea and pneumonia, including beta-lactamases (blaCMY, blaCTX-M, blaTEM), tetracycline resistance genes (tetA, tetB, tetM, tetO), aminoglycoside resistance genes (strA, strB, aadA), sulfonamide resistance genes (sul1, sul2), phenicol resistance genes (cat, floR), and macrolide/lincosamide resistance genes (cfr, ermB).
Molecular Epidemiology and Antimicrobial Resistance of Clostridioides difficile in Hospitalized Patients From Mexico.
The study identified several AMR genes and mutations in C. difficile isolates from Mexico, including cfrE, ermB, aadE, aadA27, aac(6')-Ie-aph(2'')-Ia, catP, blaCDD2, blaCCD1, tetM, tetO, tetB, tetA, and cdeA, along with mutations in rpoB, rpoC, fusA, and pbp2 associated with resistance to various antibiotics.
Acute and persistent effects of commonly used antibiotics on the gut microbiome and resistome in healthy adults.
The study identified increased resistance gene burden in healthy volunteers after antibiotic treatment, particularly with cfxA, tetO, and tet40 genes associated with β-lactam and tetracycline resistance.
Genotyping, antibiotic resistance and prevalence of Arcobacter species in milk and dairy products.
The study identifies bla OXA-61 and tet(O) as resistance genes in Arcobacter species isolated from milk, indicating resistance to amoxicillin-clavulanic acid and tetracycline.
The antimicrobial systems of Streptococcus suis promote niche competition in pig tonsils.
Strain WUSS351 is multidrug-resistant and possesses several antimicrobial systems, including the ABC transporter system sstFEG and Bce system genes bceBA and bceSR, which confer bacitracin resistance. Additionally, the macrolide-lincosamide-streptogramin B resistance gene erm(B) and the tetracycline resistance gene tet(O) were identified.
Prevalence, Antimicrobial Resistance, and Molecular Characterization of Campylobacter Isolated from Broilers and Broiler Meat Raised without Antibiotics.
The study identified several antimicrobial resistance genes in Campylobacter isolates, including gyrA, tet(O), blaOXA-61, blaOXA-184, and aph(3')-IIIa, which confer resistance to fluoroquinolones, tetracycline, beta-lactamases, and aminoglycosides, respectively.
Characterization of Campylobacter jejuni in large-billed crows (Corvus macrorhynchos) in Tochigi prefecture, Japan.
The study identified tetracycline resistance mediated by the tetO gene and streptomycin resistance mediated by the aadE gene in Campylobacter jejuni isolates from large-billed crows in Japan.
A review of the emergence of antibiotic resistance in bioaerosols and its monitoring methods.
This review highlights the presence of various antibiotic resistance genes (ARGs) in bioaerosols, emphasizing their role in the spread of antibiotic resistance through horizontal gene transfer. Key ARGs identified include those conferring resistance to beta-lactams, tetracyclines, sulfonamides, quinolones, and macrolides.
Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance.
The paper discusses the resurgence of tetracycline-class antibiotics, highlighting their effectiveness against various bacterial infections, including those resistant to other antibiotics. It identifies key resistance mechanisms such as efflux pumps and ribosomal protection proteins, and emphasizes the importance of these antibiotics in combating multidrug-resistant pathogens.
Differences in the Propensity of Different Antimicrobial Resistance Determinants to Be Disseminated via Transformation in Campylobacter jejuni and Campylobacter coli.
The study identified that the aminoglycoside phosphotransferase gene aph(2")-If confers resistance to gentamicin and kanamycin, and the tetracycline resistance gene tet(O) confers resistance to tetracycline in Campylobacter jejuni and Campylobacter coli.
Comparative genomics analysis and virulence-related factors in novel Aliarcobacter faecis and Aliarcobacter lanthieri species identified as potential opportunistic pathogens.
The study identified tetracycline resistance genes tet(O) and tet(W) in Aliarcobacter faecis and Aliarcobacter lanthieri through PCR assays, indicating the prevalence of tetracycline resistance within the genus Aliarcobacter.
Genetic background of Cambodian pneumococcal carriage isolates following pneumococcal conjugate vaccine 13.
The study identified multiple antimicrobial resistance (AMR) genes in Cambodian pneumococcal carriage isolates, including ermB, mefA, cat, tet(M), tet(O), folA, and folP, which confer resistance to erythromycin, chloramphenicol, tetracycline, trimethoprim, and sulfamethoxazole. These genes were validated through predictive resistance profiling using the CDC-AMR pipeline.
Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches.
The study identifies several AMR genes and mutations associated with resistance to various antibiotics in wastewater environments, highlighting the role of these genes in the spread of antimicrobial resistance.
Genomic Characterization of Enterococcus hirae From Beef Cattle Feedlots and Associated Environmental Continuum.
The study identified several AMR genes in Enterococcus hirae isolates from beef cattle feedlots, including tetracycline resistance genes (tet(L), tet(M), tet(O), tet(S/M), tet(O/32/O)), macrolide resistance gene erm(B), and aminoglycoside resistance genes (aac(6')-Iid, ant(6)-Ia, aph(3')-III, sat4).
Genomic Characterization of Enterococcus hirae From Beef Cattle Feedlots and Associated Environmental Continuum.
The study identified several AMR genes in Enterococcus hirae isolates from beef cattle feedlots, including tetracycline resistance genes (tet(L), tet(M), tet(O), tet(S/M), tet(O/32/O)), macrolide resistance gene erm(B), and aminoglycoside resistance genes (aac(6')-Iid, ant(6)-Ia, aph(3')-III, sat4).
Investigation of Antimicrobial Susceptibilities and Resistance Genes of Campylobacter Isolates from Patients in Edirne, Turkey.
Virulence Profiling, Multidrug Resistance and Molecular Mechanisms of Campylobacter Strains from Chicken Carcasses in Tunisia.
The study identified multiple AMR genes and mutations in Campylobacter strains from chicken carcasses in Tunisia, highlighting the presence of multidrug-resistant strains with high resistance rates to various antibiotics.
Should We Consider Them as a Threat? Antimicrobial Resistance, Virulence Potential and Genetic Diversity of Campylobacter spp. Isolated from Varsovian Dogs.
The study identified high levels of ciprofloxacin resistance in Campylobacter isolates, primarily due to a point mutation in the gyrA gene. Tetracycline resistance was linked to the presence of the tetO gene. Ampicillin resistance was prevalent but its determinants were not determined.
The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs.
The study identified ermG as a gene that increased in abundance in the feces of treated pigs compared to those that did not receive post-PRRS antimicrobials, indicating its role in macrolide, lincosamide, and streptogramin B resistance.
Exploring the Bacteriome and Resistome of Humans and Food-Producing Animals in Brazil.
The study identified various antimicrobial resistance genes (ARGs) in humans and food-producing animals in Brazil, including novel carbapenemase-encoding genes such as blaAIM-1, blaCAM-1, blaGIM-2, and blaHMB-1, which were not previously reported in Latin America. Other significant ARGs included aac(6')-Ib-cr, ermF, ermB, ermG, tetO, tetQ, tetW, qnrB10, qnrB19, qnrD1, and crpP.
Tetracycline, Macrolide and Lincosamide Resistance in Streptococcus canis Strains from Companion Animals and Its Genetic Determinants.
The study identified tetracycline resistance genes tet(O), tet(M), and tet(T), and MLS resistance genes erm(B) and erm(TR) in Streptococcus canis strains from companion animals.
Withdrawal of antibiotic growth promoters in China and its impact on the foodborne pathogen Campylobacter coli of swine origin.
The study found that the withdrawal of antibiotic growth promoters in China led to an increase in antibiotic resistance in Campylobacter coli, particularly for gentamicin and florfenicol. Several resistance genes, including aadE-Cc, aac(6')-aph(2"), ant(6)-la, aph(3")-lll, aph(2")-lf, tet(O), tet(M), tet(O/32/O), cat, fexA, cfr(C), optrA, blaOXA-193, blaOXA-489, and blaOXA-61, were identified. Mutations in 23S rRNA and gyrA were also associated with resistance to erythromycin and ciprofloxacin, respectively.
Antibiotic-Resistant Bacteria and Resistance Genes in Isolates from Ghanaian Drinking Water Sources.
The study identified antibiotic-resistant bacteria carrying resistance genes such as bla_NDM-1, sul1, tet(O), and tet(W) in Ghanaian drinking water sources, highlighting the presence of multidrug-resistant isolates and the potential public health risks associated with contaminated water.
Prevalence, antimicrobial resistance, virulence gene profile and molecular typing of Campylobacter species isolated from poultry meat samples.
The study identified several AMR genes, including aadE1, blaOXA-61, tet(O), and cmeB, in Campylobacter jejuni and C. coli isolates from poultry meat samples. These genes conferred resistance to various antibiotics such as erythromycin, ampicillin, ciprofloxacin, chloramphenicol, and tetracycline.
Comparative Analysis of the Molecular Characteristics of Group B Streptococcus Isolates Collected from Pregnant Korean Women Using Whole-genome Sequencing.
The study identified ermB, ermA, tetM, and tetO as genes conferring resistance to erythromycin and tetracycline in Group B Streptococcus isolates from pregnant Korean women.
Comparison of Antimicrobial Susceptibility Profiles of Thermotolerant Campylobacter spp. Isolated from Human and Poultry Samples in Georgia (Caucasus).
The study identified tetracycline resistance mediated by the tet(O) gene, beta-lactam resistance conferred by blaOXA-61 family genes, and putative streptomycin resistance from the aadE-Cc gene in Campylobacter isolates from Georgia. Additionally, the gyrA T86I mutation was linked to ciprofloxacin resistance.
Quantitative detection and genetic characterization of thermotolerant Campylobacter spp. in fresh chicken meats at retail in Japan.
The study identified three antimicrobial resistance genes (gyrA substitution T86I, tetO, and blaOXA-61) in Campylobacter jejuni isolates from fresh chicken meats in Japan.
Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 Streptococcus suis isolates from healthy pigs.
The study identified 18 AMR genes in non-serotype 2 Streptococcus suis isolates from healthy pigs, including genes conferring resistance to aminoglycosides, macrolides, lincosamides, tetracyclines, oxazolidinones, nucleosides, and phenicols.
Serious Risk of Tigecycline Resistance in Escherichia coli Isolated from Swine Manure.
The study identifies the presence of various tetracycline resistance genes (TRGs) in doxycycline-resistant E. coli (DRE) strains isolated from swine manure, highlighting the significant risk of tigecycline resistance. The tetX and tet(X4) genes were found to be strongly associated with tigecycline resistance.
Prevalence, Tetracycline Resistance and Tet(O) Gene Identification in Pathogenic Campylobacter Strains Isolated from Chickens in Retail Markets of Lima, Peru.
The study identifies the Tet(O) gene as a major contributor to tetracycline resistance in Campylobacter strains isolated from chicken in Lima, Peru.
Antimicrobial resistance: mechanisms and implications
The review discusses various molecular mechanisms of antibiotic resistance, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and efflux pumps, highlighting their roles in conferring resistance to multiple antibiotics.
Relationships between Virulence Genes and Antibiotic Resistance Phenotypes/Genotypes in Campylobacter spp. Isolated from Layer Hens and Eggs in the North of Tunisia: Statistical and Computational Insights.
The study identified several AMR genes and mutations in Campylobacter isolates from layer hens and eggs in Tunisia, including tet(O), cmeB, erm(B), blaOXA-61, and mutations in gyrA and 23S rRNA. These genes and mutations were associated with resistance to tetracycline, fluoroquinolones, macrolides, and beta-lactams.
Comparative virulence and antimicrobial resistance distribution of Streptococcus suis isolates obtained from the United States.
The study identified several antimicrobial resistance (AMR) genes in Streptococcus suis isolates from the United States, including ble, tetO, ermB, lsaE, lnuB, ant(9)-Ia, and ant(6)-Ia, which confer resistance to glycopeptides, tetracyclines, macrolide-lincosamide-streptogramin B, pleuromutilins, and aminoglycosides respectively.
Clonal Complex 12 Serotype Ib Streptococcus agalactiae Strain Causing Complicated Sepsis in Neonates: Clinical Features and Genetic Characteristics.
The study identifies the presence of the integrative and conjugative element ICE Sag37 in type Ib ST12 GBS isolates, which carries multiple antibiotic resistance genes such as erm(B), tet(O), aadE, aphA, ant-6, lsa(E), and lun(B), contributing to high resistance rates to erythromycin and clindamycin. Additionally, the virulence gene pezT was found in these isolates.
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
The study found that prolonged amoxicillin treatment leads to an increase in the abundance and diversity of antimicrobial resistance genes (ARGs) in the gut microbiome, particularly beta-lactamase genes such as cfxA and its variants, as well as tetracycline and macrolide resistance genes.
Whole-Genome and Plasmid Comparative Analysis of Campylobacter jejuni from Human Patients in Toyama, Japan, from 2015 to 2019.
The study identified tetracycline resistance gene tet(O), aminoglycoside resistance genes ant(6)-Ia and aph(3')-III, and chloramphenicol resistance gene cat in Campylobacter jejuni isolates from Toyama, Japan. Additionally, blaOXA-184 was found in ampicillin-resistant isolates.
Antibiotic resistance genes and molecular typing of Streptococcus agalactiae isolated from pregnant women.
The study identified several antibiotic resistance genes in Streptococcus agalactiae isolates from pregnant women, including ermB, mefA/E, ermTR, tetM, tetO, and aphA3, which confer resistance to macrolides, tetracyclines, and aminoglycosides.
Molecular epidemiology, drug resistance, and virulence gene analysis of Streptococcus agalactiae isolates from dairy goats in backyard farms in China.
The study identified multiple AMR genes in S. agalactiae isolates from dairy goats in China, including pbp2b, tetL, tetM, tetK, tetO, ermA, ermB, mefA, aphA3, aad6, lnu(B), gryA, and parC, which confer resistance to various antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, lincosamides, and quinolones.
Broiler house environment and litter management practices impose selective pressures on antimicrobial resistance genes and virulence factors of Campylobacter.
The study identified tetracycline resistance gene tetO in C. coli isolates, beta-lactamase gene blaOXA-61 in C. coli and C. jejuni isolates, and multidrug efflux pumps cmeABC and cmeDEF. These genes were found to differ by species and flock cohort.
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteria.
The study identified several acquired and intrinsic antimicrobial resistance genes in lactic acid bacteria and bifidobacteria, including tetW, ANT(6)-Ia, aac(6')-Ie-APH(2'')-Ia, erm(B), erm(49), cat, dfrG, arr-4, and fosXCC. Additionally, mutations in S12, rsmG, Lsa(A), MsrC, and PBP5 were associated with resistance to various antibiotics.
Campylobacter spp. isolated from poultry in Iran: Antibiotic resistance profiles, virulence genes, and molecular mechanisms.
The study identified blaOXA-61, tet(O), aadE1, aphA-3-1, and cmeB as key AMR genes in Campylobacter isolates from poultry in Iran, highlighting their role in resistance to beta-lactams, tetracyclines, aminoglycosides, and fluoroquinolones.
Streptococcus suis outbreak caused by an emerging zoonotic strain with acquired multi-drug resistance in Thailand.
The study identifies multiple AMR genes, including tetO, ermB, optrA, and ermA, in a multidrug-resistant S. suis strain causing an outbreak in Thailand.
Correlations among Antibiotic Resistance Genes, Mobile Genetic Elements and Microbial Communities in Municipal Sewage Treatment Plants Revealed by High-Throughput Sequencing.
The study identifies various tetracycline resistance genes (tetC, tetE, tetG, tetM, tetO, tetQ, tetW, tetX), sulfonamide resistance gene (sulI), aminoglycoside resistance genes (ant(2')-Ia, ant(3')-Ia, aph(6')-Id, aph(33')-Ib, aac(6')-Ib), beta-lactam resistance genes (blaGES, blaVEB), chloramphenicol resistance gene (catB3), MLS resistance genes (ereA, ermB), and multidrug resistance genes (acrB, mexB, mexF) in municipal sewage treatment plants, highlighting their association with mobile genetic elements and microbial communities.
Antimicrobial Resistance and Virulence Genes of Streptococcus Agalactiae Isolated from Mastitis Milk Samples in China.
The study identified several AMR genes in multidrug-resistant Streptococcus agalactiae isolates from bovine mastitis milk samples in China, including ermB, ermA, lnuA, tetM, tetK, tetS, and tetO. These genes conferred resistance to macrolides, lincosamides, and tetracyclines.
Antimicrobial resistance in Campylobacter fetus: emergence and genomic evolution.
The study identified several AMR genes and mutations in Campylobacter fetus, including ant(6)-Ib, aph(3')-III, tet(O), tet(44), and cat, which confer resistance to various antibiotics. Mutations in the gyrA gene were also found to contribute to fluoroquinolone resistance.
Genomic insight into Campylobacter jejuni isolated from commercial turkey flocks in Germany using whole-genome sequencing analysis.
The study identified multiple beta-lactam resistance genes (blaOXA variants), tetracycline resistance gene tet(O), aminoglycoside resistance genes (aadE, aph(3')-IIIa, sat4), and a fluoroquinolone resistance mutation (gyrA T86I) in Campylobacter jejuni isolates from German turkey flocks.
Antimicrobial Usage, Susceptibility Profiles, and Resistance Genes in Campylobacter Isolated from Cattle, Chicken, and Water Samples in Kajiado County, Kenya.
The study identified several AMR genes in Campylobacter isolates, including tet(O), blaOXA-61, aph-3-1, gyrA, and cmeB, which confer resistance to tetracycline, ampicillin, gentamicin, ciprofloxacin, and multiple antibiotics. High levels of multidrug resistance were observed, highlighting the urgent need for improved antimicrobial stewardship.
Genomic comparison of two Streptococcus suis serotype 1 strains recovered from porcine and human disease cases.
The study identified tetracycline resistance gene tet(O), macrolide-lincosamide-streptogramin resistance gene erm(B), and aminoglycoside resistance genes ant(6)-Ia and aph(3')-III in two Streptococcus suis serotype 1 strains.
Whole genome characterization of thermophilic Campylobacter species isolated from dairy manure in small specialty crop farms of Northeast Ohio.
The study identified various antimicrobial resistance genes in Campylobacter isolates from dairy manure, including blaOXA-193, aadE-Cc, gyrA_T86I, tetO, aph3'-IIIa, rpsL_K88R, and 50S_L22_A103V, indicating multidrug resistance in these isolates.
Distribution analysis of tetracycline resistance genes in Escherichia coli isolated from floor surface and effluent of pig slaughterhouses in Banten Province, Indonesia.
The study identified the distribution of tetracycline resistance genes (tetA, tetB, tetC, tetE, tetM, tetO, and tetX) in Escherichia coli isolates from pig slaughterhouses in Banten Province, Indonesia. The tetO gene was the most dominant in floor surface samples, while tetA was dominant in effluent samples.
Genomic Epidemiology of Corynebacterium diphtheriae in New Caledonia.
The study identified tetracycline resistance in Corynebacterium diphtheriae isolates from New Caledonia, with the tetO gene being responsible for this resistance. The research highlights the circulation of genetically diverse C. diphtheriae sublineages, including a predominant tetracycline-resistant sublineage harboring the tetO gene.
Genomic characterization of emerging invasive Streptococcus agalactiae serotype VIII in Alberta, Canada.
The study identified mprF, tetO, and ermA as the primary antimicrobial resistance genes in invasive Streptococcus agalactiae serotype VIII isolates in Alberta, with mprF providing resistance to peptide antibiotics, tetO to tetracycline, and ermA to macrolides, lincosamides, and streptogramin B.
Epidemiological and genomic analyses of human isolates of Streptococcus suis between 2005 and 2021 in Shenzhen, China.
The study identified multiple antimicrobial resistance genes in human isolates of Streptococcus suis, including ant(6)-Ia, tet(O), and erm(B), which confer resistance to streptomycin, tetracycline, and erythromycin/clindamycin respectively.
Comparative genomic analyses of the clinically-derived Winkia strain NY0527: the reassignment of W. neuii subsp. neuii and W. neuii subsp. antitratus into two separate species and insights into their virulence characteristics.
The study identifies ermX, tetO, and rpoB as AMR genes in Winkia strains, highlighting differences in resistance profiles between W. neuii and W. anitratus.
Antibiotic Resistance Patterns and Molecular Characterization of Streptococcus suis Isolates from Swine and Humans in China.
The study identified 24 antibiotic resistance genes (ARGs) in 96 Streptococcus suis isolates, including erm(B), tet(O), ant(6)-Ia, and optrA, which confer resistance to multiple antibiotic classes such as macrolides, tetracyclines, aminoglycosides, and linezolid. These genes were found in isolates from both swine and humans in China.
Impact of immigration on antibiotic resistance genes in activated sludge: A study using digital droplet PCR and amplicon sequencing
The study reveals that immigration of influent wastewater into activated sludge leads to an increase in the abundance of over 70% of the quantified antibiotic resistance genes (ARGs). Specific ARGs such as blaTEM, blaMOX, qnrS, qnrB, mphE, dfrA, tetO, tetQ, tetE, marR, msrD, robA, qacL, blaOXA, and ereA were found to increase in abundance with immigration, indicating the impact of influent immigration on the persistence of AMR in wastewater treatment plants.
Persistence of Campylobacter spp. in Poultry Flocks after Disinfection, Virulence, and Antimicrobial Resistance Traits of Recovered Isolates.
The study identified the presence of AMR genes such as bla OXA-61, cmeB, and tet(O) in Campylobacter isolates, along with mutations in gyrA and 23S rRNA genes that contribute to resistance against various antibiotics.
Genomic Analysis and Antimicrobial Resistance of Campylobacter jejuni Isolated from Diarrheal Patients - Beijing Municipality, China, 2019-2021.
The study identified high levels of resistance to quinolones and tetracycline in Campylobacter jejuni isolates from Beijing, with the gyrA_T86I mutation and tetO gene being the most prevalent. The cmeABC operon was also commonly found and contributes to multidrug resistance.
Prevalence, genomic characterization and antimicrobial resistance of Campylobacter spp. isolates in pets in Shenzhen, China.
The study identified multiple AMR genes and mutations in Campylobacter spp. isolates from pets in Shenzhen, China, highlighting the high prevalence of multidrug resistance, particularly in C. upsaliensis. Key findings include the detection of gyrA mutations, aminoglycoside resistance genes (aac(6')-aph(2"), aph(2")-Ifl), tetracycline resistance genes (tet(O)), and beta-lactam resistance genes (OXA-193, OXA-595).
Multidrug-resistant Campylobacter jejuni, Campylobacter coli and Campylobacter lari isolated from asymptomatic school-going children in Kibera slum, Kenya.
The study identified multidrug-resistant strains of Campylobacter jejuni, Campylobacter coli, and Campylobacter lari in asymptomatic schoolchildren in Kenya, with high resistance rates to tetracycline, ciprofloxacin, nalidixic acid, and erythromycin. The most prevalent tetracycline resistance genes were tet(A), tet(O), and tet(C).
The Genetic Diversity and Antimicrobial Resistance of Pyogenic Pathogens Isolated from Porcine Lymph Nodes.
The study identified tetracycline resistance genes tetM and tetO, and erythromycin resistance gene ermB in Streptococcus dysgalactiae isolates from porcine lymph nodes.
Genomic characterization and virulence of Streptococcus suis serotype 4 clonal complex 94 recovered from human and swine samples.
The study identified the presence of antimicrobial resistance genes tet(O) and erm(B) in all seven Streptococcus suis serotype 4 strains, which confer resistance to tetracycline, erythromycin, azithromycin, and clindamycin.
Whole-genome sequencing reveals changes in genomic diversity and distinctive repertoires of T3SS and T6SS effector candidates in Chilean clinical Campylobacter strains.
The study identified a high genetic diversity among C. jejuni strains and detected mutations in the gyrA gene associated with fluoroquinolone resistance. No macrolide-resistance determinants were found, but tetracycline resistance genes (tetO) and beta-lactamase genes (blaOXA-61, blaOXA-193, blaOXA-450, blaOXA-605) were prevalent. Aminoglycoside resistance genes (aph(2")-If, aac(6')-Im, ant(6)-Ia) and multidrug efflux pump genes (cmeABC) were also detected in a multi-resistant strain.
Pangenomic analyses of antibiotic-resistant Campylobacter jejuni reveal unique lineage distributions and epidemiological associations.
The study identifies various antibiotic resistance genes including bla(OXA-193), bla(OXA-460), tet(O), and aph(3')-III in Campylobacter jejuni strains, highlighting the prevalence of multidrug resistance and the significance of specific lineages in Michigan.
Genomic and Antimicrobial Surveillance of Campylobacter Population in Italian Poultry.
The study identified several AMR genes and mutations in Campylobacter isolates from Italian poultry, highlighting the emergence of multidrug-resistant strains and the prevalence of specific resistance mechanisms such as the T86I mutation in gyrA and the tet(O) gene.
Social demographics determinants for resistome and microbiome variation of a multiethnic community in Southern Malaysia.
The study identified 1038 antibiotic resistance genes from 200 community participants, highlighting the association of resistome profiles with lifestyle and environmental factors, particularly emphasizing the role of Escherichia coli in the resistome dynamics.
Genetic characteristics, antimicrobial susceptibility, and virulence genes distribution of Campylobacter isolated from local dual-purpose chickens in central China.
The study identified the gyrA T86I mutation and tet(O) as the most prevalent resistance mechanisms in Campylobacter isolates from local dual-purpose chickens in central China, with high resistance rates to ciprofloxacin and tetracycline.
Prevalence and genetic characterization of Campylobacter from clinical poultry cases in China.
The study identified high prevalence of Campylobacter in diseased poultry in China, with resistance genes gyrA (T86I), tet(O), and blaOXA-605 being the most prevalent.
Detection of tetracycline resistance genes and their diversity in Escherichia coli isolated from pig farm waste in Banten province, Indonesia.
The study identified several tetracycline resistance genes, including tetA, tetB, tetC, tetM, tetO, and tetX, in Escherichia coli isolated from pig farm waste in Banten province, Indonesia. tetX and tetO were the most prevalent genes, with high frequencies detected in both solid waste and wastewater samples.
Virulence factors and antimicrobial resistance profiles of Campylobacter isolates recovered from consecutively reused broiler litter.
The study identified tetracycline resistance gene tetO in C. coli isolates, beta-lactamase gene blaOXA-61 in C. coli and C. jejuni isolates, multidrug efflux pumps cmeABC and cmeDEF, and arsenic resistance genes acr3, arsP, and arsB in C. jejuni isolates.
Virulence genotype and phenotype of two clinical isolates of Arcobacter butzleri obtained from patients with different pathologies.
The study identified tetracycline resistance genes tetO and tetA, as well as the beta-lactamase gene bla3, in the clinical isolates of Arcobacter butzleri. These genes conferred resistance to tetracycline, ampicillin, and amoxicillin-clavulanic acid.
Assessing the nonlinear association of environmental factors with antibiotic resistance genes (ARGs) in the Yangtze River Mouth, China.
The study identified tetBP, ampr, and tetO as key antibiotic resistance genes associated with environmental factors in the Yangtze River Mouth. High concentrations of amoxicillin, phosphorus, chromium, manganese, calcium, and strontium were linked to increased ARG abundance.
Prevalence and antimicrobial resistance of Campylobacter species in shelter-housed healthy and diarrheic cats and dogs in Turkey.
The study identified tetO and aphA-3 genes associated with tetracycline and gentamicin resistance, respectively, in Campylobacter jejuni isolates. Additionally, the Thr-86-Ile mutation in the gyrA gene was found to confer resistance to quinolone antibiotics.
Genotypic characterization, antimicrobial susceptibility and virulence determinants of Campylobacter jejuni and Campylobacter coli isolated from pastured poultry farms.
The study identified the tetO gene associated with tetracycline resistance and the ermB gene associated with erythromycin resistance in Campylobacter jejuni and Campylobacter coli isolates from pastured poultry farms. Additionally, a Thr86Ile mutation in the gyrA gene was found to confer resistance to quinolones in both species.
A novel invasive Streptococcus pyogenes variant sublineage derived through recombinational replacement of the emm12 genomic region.
The study identifies a novel sublineage of Streptococcus pyogenes (emm82/ST36) that emerged through recombinational replacement of the emm12 genomic region, exhibiting diverse resistance mechanisms including macrolide and tetracycline resistance.
Clostridium neonatale antimicrobial susceptibility, genetic resistance determinants, and genotyping: a multicentre spatiotemporal retrospective analysis.
The study identified several AMR genes in Clostridium neonatale, including erm(B), tet(O), tet(32), tet(M), bla TEM-116, bla CBP-1-like, and aph(3')-IIa, which confer resistance to clindamycin, tetracycline, cefotaxime, and gentamicin. These genes are associated with mobile genetic elements.
Campylobacter prophage diversity reveals pervasive recombination between prophages from different Campylobacter species.
The study identifies a tetracycline resistance gene (tetO) encoded in a prophage from Campylobacter coli, highlighting the role of prophages in antibiotic resistance gene dissemination.
Antibiotic resistance, bacterial transmission and improved prediction of bacterial infection in patients with antibody deficiency.
The study identifies high levels of antibiotic resistance in respiratory tract bacteria from patients with antibody deficiency, particularly macrolide resistance genes erm(B) and mef(A), and highlights the role of commensal streptococci as reservoirs for resistance genes.
The fate of antibiotic resistance genes during anaerobic digestion of sewage sludge with ultrasonic pretreatment.
The study investigated the effect of ultrasonic pretreatment on the fate of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) during anaerobic digestion of sewage sludge. It found that ultrasonic pretreatment significantly reduced the relative abundance of ARGs and MGEs, with 60 minutes of pretreatment achieving the highest removal rate of 41.70% for total ARGs.
Shotgun Metagenomics-Guided Prediction Reveals the Metal Tolerance and Antibiotic Resistance of Microbes in Poly-Extreme Environments in the Danakil Depression, Afar Region.
The study identified numerous antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in the metagenomes of Lake Afdera and the Assale salt plain in the Danakil Depression. Key ARGs included beta-lactamases (ACC-1, OXA-58, OXA-363, OXA-212, NDM-17, OXA-134, ACT-29, LRA-19), efflux pumps (emrB, abeM, abeS, mgrA, adeJ, MexC, adeL, adeH), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet39, tetX, tetK), and others. MRGs included copper resistance genes (copC, copD), cadmium resistance gene (cadD), mercury resistance gene (merA), chromate resistance genes (chrB, chrA), nickel-cobalt-cadmium resistance genes (nccA, nccB), cobalt-zinc-cadmium resistance gene (czcD), arsenic resistance gene (arsO), lead resistance gene (pbrA), and mercury resistance genes (merB, merR, MIR).
Multiplex Real-Time PCR for the Detection of Tetracycline, Ciprofloxacin, and Erythromycin Resistance Determinants from Human and Foodborne Campylobacter jejuni and Campylobacter coli.
The study developed a multiplex real-time PCR assay to detect tetracycline, ciprofloxacin, and erythromycin resistance determinants in Campylobacter jejuni and Campylobacter coli. The assay successfully detected tet(O), erm(B), GyrA_T86I/V, and A2075G mutations.
Molecular characterisation and antimicrobial resistance of Streptococcus agalactiae isolates from dairy farms in China.
The study identified tetracycline resistance genes tet(M), tet(O), and erythromycin resistance gene erm(B) in Streptococcus agalactiae isolates from dairy farms in China.
Effects of Neolamarckia cadamba leaves extract on microbial community and antibiotic resistance genes in cecal contents and feces of broilers challenged with lipopolysaccharides.
The study found that Neolamarckia cadamba leaves extract (NCLE) reduced the abundance of antibiotic resistance genes (ARGs) in cecal contents of lipopolysaccharide (LPS)-induced broilers by maintaining microbial balance.
Streptococcus suis Research Update: Serotype Prevalence and Antimicrobial Resistance Distribution in Swine Isolates Recovered in Spain from 2020 to 2022.
The study identified the prevalence of antimicrobial resistance genes in Streptococcus suis isolates from Spain, including tet(O), erm(B), lnu(B), lsa(E), tet(M), and mef(A/E). High resistance levels were observed for clindamycin, chlortetracycline, and sulfadimethoxine.
Metagenomics reveals the temporal dynamics of the rumen resistome and microbiome in goat kids.
The study identified numerous antibiotic resistance genes (ARGs) in the rumen of goat kids, highlighting the dynamic nature of the resistome influenced by age and diet. Key ARGs included RPOB, GYRA, GYRBA, ROB, MDTF, ACRF, ACRB, MGTA, MLS23S, TUFAB, TET44, TET32, APH2-DPRIME, SAT, BRO, TETQ, ERMF, NIMJ, ACI, MEFA, RRSC, RRSH, CAP16S, TETX, LNUC, TETW, TETO, and TET40, which were associated with resistance to various antibiotics such as drugs, MLS, tetracyclines, and others.
Probiotic-Induced Modulation of Microbiota Composition and Antibiotic Resistance Genes Load, an In Vitro Assessment.
The study found that probiotics significantly reduced the levels of tetM and tetO genes, as well as the blaTEM gene, in fecal cultures from both normal-weight and extremely obese individuals.
Antibiotic resistance, plasmids, and virulence-associated markers in human strains of Campylobacter jejuni and Campylobacter coli isolated in Italy.
The study identified ciprofloxacin resistance mediated by GyrA (T86I) mutation and tetracycline resistance conferred by the tet(O) gene in Campylobacter jejuni and Campylobacter coli strains. Erythromycin resistance was associated with 23S rRNA gene mutation (A2075G) in C. coli. The blaOXA gene was prevalent in both species.
Genomic resistant determinants of multidrug-resistant Campylobacter spp. isolates in Peru.
Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China.
The study identifies various antimicrobial resistance genes in Clostridioides difficile isolates from children, including those conferring resistance to aminoglycosides, macrolides, fluoroquinolones, glycopeptides, lincosamides, tetracyclines, and others. Notably, the pCD-METRO plasmid and vanA/B were not detected, indicating alternative resistance mechanisms.
Prevalence, antibiotic resistance, and genomic characterisation of Campylobacter spp. in retail chicken in Hanoi, Vietnam.
The study identified multiple AMR genes and mutations in Campylobacter isolates from retail chicken in Hanoi, Vietnam, including aminoglycoside resistance genes (aadE, aadA9, aph(2'')-If, aac(6')-Ie/aph(2'')-Ia), erythromycin resistance gene ermB, tetracycline resistance gene tet(O), beta-lactam resistance gene blaOXA-193, and a quinolone resistance mutation (T86I) in gyrA.
Identification of knowledge gaps in whole-genome sequence analysis of multi-resistant thermotolerant Campylobacter spp.
The study identified 22 different resistance genes and gene variants, including erm(B), aph(3')-IIIa, aadE, catA, lnu(C), blaOXA, sat4, tet(O), and point mutations in gyrA, 23S rRNA, and rpsL, associated with antimicrobial resistance in thermotolerant Campylobacter spp.
Overview of Ecology and Aspects of Antibiotic Resistance in Campylobacter spp. Isolated from Free-Grazing Chicken Tissues in Rural Households.
The study identified several AMR genes and mutations in Campylobacter spp. isolated from free-grazing chickens, including blaOxA-61, tet(O), tet(A), cmeA, cmeB, cmeC, and a Thr-86-Ile mutation in gyrA, contributing to multidrug resistance.
The effects of antibiotic exposures on the gut resistome during hematopoietic cell transplantation in children.
The study identified 372 unique antibiotic resistance genes (ARGs) in the gut microbiome of children undergoing hematopoietic cell transplantation, with tetracycline, beta-lactam, and fluoroquinolone resistance genes being the most prevalent. Anaerobic antibiotic exposures were associated with an increase in the acquisition of new ARGs and the relative abundance of ARGs in the gut resistome.
Antimicrobial resistance patterns and genes of Campylobacter jejuni isolated from chickens in Pasuruan, Indonesia.
The study identified high resistance to enrofloxacin (92.9%) and ciprofloxacin (89.3%) in C. jejuni isolates, with 100% of isolates carrying the gyrA gene, 96.4% carrying blaOXA-61, and 50% carrying tetO.
Antimicrobial susceptibility and resistome of Actinobacillus pleuropneumoniae in Taiwan: a next-generation sequencing analysis.
The study identified multiple antimicrobial resistance genes in Actinobacillus pleuropneumoniae isolates from Taiwan, including aminoglycoside, tetracycline, beta-lactam, macrolide, and phenicol resistance genes, highlighting the prevalence of multidrug resistance.
Streptococcus suis serotype 4: a population with the potential pathogenicity in humans and pigs.
The study identified multiple antibiotic resistance genes in Streptococcus suis serotype 4, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, oxazolidinones, and chloramphenicol. Prophages were identified as the primary vehicle for the dissemination of these resistance genes.
Genomic insights into the diversity, virulence, and antimicrobial resistance of group B Streptococcus clinical isolates from Saudi Arabia.
The study identified several AMR genes including erm(B), erm(A), lsa(C), mef(A), tet(M), tet(O), aac(6')-aph(2''), ant(6)-Ia, aph(3')-III, and aadE in GBS isolates from Saudi Arabia, highlighting the prevalence of resistance to macrolides, lincosamides, tetracycline, and aminoglycosides.
Chlorogenic acid attenuates tet (X)-mediated doxycycline resistance of Riemerella anatipestifer.
The study identifies tet(X), tet(A), and tet(O) as key tetracycline resistance genes in Riemerella anatipestifer, demonstrating their role in doxycycline resistance. Chlorogenic acid was found to reduce the expression of these genes and enhance susceptibility to doxycycline.
Detection of Salmonella Pathogenicity Islands and Antimicrobial-Resistant Genes in Salmonella enterica Serovars Enteritidis and Typhimurium Isolated from Broiler Chickens.
The study identified several antimicrobial-resistant genes in Salmonella enterica serovars Enteritidis and Typhimurium isolated from broiler chickens, including tet(K), tet(O), tet(A), mcr-1, mcr-4, strA, strB, aadA, aadE, sulI, ampC, TEM, CTX-M, and OXA. These genes conferred resistance to tetracycline, colistin, aminoglycosides, sulfonamides, and beta-lactam antibiotics.
Metagenomic Investigation of the Short-Term Temporal and Spatial Dynamics of the Bacterial Microbiome and the Resistome Downstream of a Wastewater Treatment Plant in the Iskar River in Bulgaria.
The study identified various antimicrobial resistance genes (ARGs) in the Iskar River downstream of a wastewater treatment plant (WWTP), including genes conferring resistance to macrolides, tetracyclines, beta-lactams, sulfonamides, and carbapenems. Notably, the carbapenemase genes bla OXA-58 and bla IMP-33-like were detected, which are typically associated with clinical settings.
Five centuries of genome evolution and multi-host adaptation of Campylobacter jejuni in Brazil.
The study identifies beta-lactam resistance genes blaOXA-193 and blaOXA-184, as well as the multidrug efflux pump operon cmeABCR in Campylobacter jejuni isolates from Brazil. Mutations in gyrA and rrn genes are associated with quinolone and macrolide resistance.
Genomic diversity of Campylobacter jejuni and Campylobacter coli isolated from the Ethiopian dairy supply chain.
The study identified blaOXA-605 and tetO genes in Campylobacter isolates from Ethiopian dairy products, along with resistance mutations in gryA (T86I) and 50S_L22 (A103V).
Genotypic characterization and antimicrobial susceptibility of human Campylobacter jejuni isolates in Southern Spain.
The study identified high resistance rates to ciprofloxacin (90.3%) and tetracycline (66.7%) in human Campylobacter jejuni isolates from southern Spain. Key resistance mechanisms included the T86I mutation in gyrA, the tet(O) gene, blaOXA-61, ant(6)-Ia, cmeABC, and the RE-cmeABC variant. These findings highlight the urgent need for improved surveillance and management strategies for Campylobacter infections.
Faecal microbiota and cytokine profiles of rural Cambodian infants linked to diet and diarrhoeal episodes.
The study identified antimicrobial resistance genes such as erm(X), tet(O), tet(O/23/O), tet(Q), and tet(W) in Bifidobacterium isolates from Cambodian infants, highlighting the presence of resistance mechanisms in the gut microbiota.
Transmission of dominant strains of Campylobacter jejuni and Campylobacter coli between farms and retail stores in Ecuador: Genetic diversity and antimicrobial resistance.
The study identified 14 resistance genes in Campylobacter jejuni and Campylobacter coli isolates, including genes conferring resistance to tetracycline, beta-lactams, and aminoglycosides. Mutations in gyrA, rplV, 23S rRNA, and rpsL were also associated with resistance to fluoroquinolones, macrolides, and aminoglycosides.
Molecular characterization of Streptococcus suis isolates recovered from diseased pigs in Europe.
The study identified high frequencies of tetracycline and macrolide resistance genes, specifically tetO and ermB, in European Streptococcus suis isolates.
Group B Streptococcus Infections in Non-Pregnant Adults, Italy, 2015-2019.
The study identified the erm(B) gene as a major contributor to macrolide resistance, tet(M) and tet(O) genes as primary determinants of tetracycline resistance, and noted a significant increase in resistance to erythromycin and clindamycin among Group B Streptococcus isolates in Italy.
Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome.
The study found that doxy-PEP use over 6 months significantly increased the proportion and expression of tetracycline resistance genes in the gut microbiome, with no significant changes in other antibiotic resistance gene classes.
ICESp1109, a Novel Hybrid Integrative Conjugative Element of Macrolide-Resistant Streptococcus pyogenes Serotype M77 Collected Between 2003 and 2017 in Poland.
The study identifies the tet(O) and erm(TR) genes as responsible for tetracycline and macrolide resistance, respectively, in Streptococcus pyogenes M77/ST63 strains. A novel hybrid integrative conjugative element, ICE Sp1109, was discovered, combining features of ICE Sp2906 and ICE Sp1108.
Campylobacter coli of porcine origin exhibits an open pan-genome within a single clonal complex: insights from comparative genomic analysis.
The study identified several AMR genes in C. coli isolates of porcine origin, including tetO, blaOXA-193, and APH (3')-IIIa, which confer resistance to tetracyclines, beta-lactams, and aminoglycosides, respectively. Additionally, a mutation in the gyrA gene (T86I) was found to confer fluoroquinolone resistance.
Diversity of Campylobacter spp. circulating in a rhesus macaque (Macaca mulatta) breeding colony using culture and molecular methods.
The study identified several AMR genes and mutations in Campylobacter spp. isolated from a rhesus macaque breeding colony, including beta-lactamase genes blaOXA-193 and blaOXA-489, aminoglycoside resistance genes aadE-Cc and aph(3')-III, tetracycline resistance gene tet(O), and mutations in 23S rRNA and gyrA that confer resistance to macrolides and quinolones respectively.
Metagenomic analysis reveals houseflies as indicators for monitoring environmental antibiotic resistance genes.
Houseflies were found to carry a variety of antibiotic resistance genes (ARGs), including multidrug, beta-lactam, bacitracin, and tetracycline resistance genes. The study highlights the potential of houseflies as indicators for monitoring environmental ARGs.
Data-Driven Approaches in Antimicrobial Resistance: Machine Learning Solutions.
This study uses unsupervised machine learning to identify patterns in AMR genes, linking gene length and resistance class to resistance mechanisms. Key AMR genes identified include sul1, sul2, cat, blaTEM, vanA, aac(6')-Ib, aph(3')-IIIa, tet(M), and tet(O).
Arcobacter species isolated from human stool samples, animal products, ready-to-eat salad mixes, and ambient water: prevalence, antimicrobial susceptibility, and virulence gene profiles.
The study identified the presence of antimicrobial resistance genes such as tet(O), blaOXA-61, aphA-3–1, and aadE1 in Arcobacter spp. isolates, highlighting the prevalence of resistance to tetracycline, beta-lactams, and aminoglycosides.
Antibiotic Resistance and Serotypes Distribution in Streptococcus agalactiae Bulgarian Clinical Isolates During the Years of 2021-2024.
The study identified several AMR genes associated with macrolide, lincosamide, and tetracycline resistance in Streptococcus agalactiae isolates from Bulgaria. These include ermB, ermA/TR, ermC, mefA, mefE, msrD, lnuB, lsaC, lsaE, tetM, and tetO. High resistance rates to macrolides (60.3%) and tetracyclines (89.1%) were observed.
New Campylobacter Lineages in New Zealand Freshwater: Pathogenesis and Public Health Implications.
The study identified aadE-Cc and tetO as the primary antimicrobial resistance genes in Campylobacter isolates, with aadE-Cc associated with streptomycin resistance in C. coli and tetO linked to tetracycline resistance in C. jejuni ST177. Additionally, blaOXA-493 and blaOXA-184 were found to confer ampicillin resistance in C. lari and C. jejuni, respectively.
Characterization of integrative and conjugative elements carrying erm(B) and tet(O) resistance determinants in streptococcus uberis isolates from bovine milk in Chiba prefecture, Japan: CompArative GEne cluster analysis toolbox with ICEfinder.
The study identified and characterized integrative and conjugative elements (ICEs) carrying the erm(B) and tet(O) resistance genes in Streptococcus uberis isolates from bovine milk in Japan. These genes confer resistance to macrolides, lincosamides, streptogramin B, and tetracyclines.
Genetic analysis reveals the genetic diversity and zoonotic potential of Streptococcus dysgalactiae isolates from sheep.
The study identified tet(M), tet(O), and erm(B) as the primary AMR genes in S. dysgalactiae isolates from sheep, contributing to resistance against doxycycline and erythromycin.
The tetracycline resistome is shaped by selection for specific resistance mechanisms by each antibiotic generation.
The study identifies specific tetracycline resistance mechanisms (efflux pumps, ribosomal protection proteins, and type 1 tetracycline destructases) that are preferentially selected by different generations of tetracycline antibiotics, highlighting the evolutionary dynamics of resistance.
Abundance of clinically relevant antimicrobial resistance genes in the golden jackal (Canis aureus) gut.
The study identified a high prevalence of clinically relevant antimicrobial resistance genes in golden jackals, including beta-lactamases (bla TEM-1, bla CTX-M-15, bla SHV), quinolone resistance (qnrS), and class 1 integrons (Int1).
Comparative Genomic Analysis of Livestock-Derived Campylobacter jejuni: Antimicrobial Resistance, Virulence, Mobile Genetic Elements, and Genetic Relatedness.
The study identified blaOXA-61, gyrA(T86I), and tet(O) as the most prevalent antimicrobial resistance genes in Campylobacter jejuni strains from livestock, contributing to resistance against beta-lactams, quinolones, and tetracyclines, respectively.
Molecular characterization of Streptococcus agalactiae strains isolated from pregnant women.
The study identified tetO and ermA genes as the most prevalent antibiotic resistance genes in Streptococcus agalactiae isolates from pregnant women, with 62.16% of isolates harboring tetO and 62.16% harboring ermA. All isolates were resistant to penicillin.
Prevalence and genetic characteristics of Campylobacter jejuni from laying-hens in Hubei Province, China.
The study identified multiple antibiotic resistance genes in Campylobacter jejuni isolates from laying-hens in Hubei Province, China, including blaOXA, tet(O), tet(M), tet(W), cmeR, and gyrA (T86I). High resistance rates were observed against ceftriaxone, enrofloxacin, doxycycline, and other antibiotics.
Relationship Between CRISPR-Cas Systems and Acquisition of Tetracycline Resistance in Non-Clinical Enterococcus Populations in Bulgaria.
The study identified tetM, tetS, tetO, and tetT genes as the primary tetracycline resistance genes in non-clinical Enterococcus populations in Bulgaria. These genes were found in various Enterococcus species, with tetM being the most prevalent. The presence of these genes was associated with the Tn916 transposon, indicating horizontal gene transfer mechanisms.
Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.
This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.
Novel insights into carbohydrate utilisation, antimicrobial resistance, and sporulation potential in Roseburia intestinalis isolates across diverse geographical locations.
The study identified tetracycline resistance genes tet(O) and tet(40), and the erythromycin resistance gene ermB in Roseburia intestinalis isolates.
Predomination of hypervirulent ST283 and genetic diversity of levofloxacin resistance in multidrug-resistant, hypervirulent Streptococcus agalactiae in Thailand.
The study identified multiple AMR genes and mutations associated with tetracycline, erythromycin, clindamycin, and levofloxacin resistance in multidrug-resistant, hypervirulent Streptococcus agalactiae isolates in Thailand, highlighting the predominance of hypervirulent ST283 and the emergence of MDR-GBS.
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.
Human milk oligosaccharide metabolism and antibiotic resistance in early gut colonizers: insights from bifidobacteria and lactobacilli in the maternal-infant microbiome.
The study investigated the metabolism of human milk oligosaccharides (HMOs) by bifidobacteria and lactobacilli isolated from human milk and mother-infant fecal samples, along with their antibiotic resistance profiles. Bifidobacterium bifidum showed the highest HMO degradation capability and was the most antibiotic-susceptible species, whereas Bifidobacterium animalis subsp. lactis was resistant to most tested antibiotics.
Phenotypic and whole genome-based characterization of antibiotic resistance of Campylobacter jejuni isolates from chicken livers.
The study identified several AMR genes and mutations in Campylobacter jejuni isolates from chicken livers, including blaOXA-185 and blaOXA-61 for beta-lactam resistance, tet(O) for tetracycline resistance, and CmeABC efflux pump for multidrug resistance. Additionally, a point mutation T86I in the gyrA gene was linked to ciprofloxacin resistance.
Genomic analysis and antimicrobial resistance in human- and poultry-derived Campylobacter jejuni isolates from Hangzhou, China.
The study identified several AMR genes and mutations in Campylobacter jejuni isolates, including gyrA mutations (T86I and T86V) associated with quinolone resistance, tet(O) for tetracycline resistance, and various beta-lactamase genes (blaOXA-61, blaOXA-193, blaOXA-450, blaOXA-451, blaOXA-452, blaOXA-453, blaOXA-489) linked to beta-lactam resistance. Additionally, aminoglycoside resistance genes APH(3')-IIIa and ant(6)-Ia were found in some isolates.
Application of MALDI-TOF MS and FT-IR spectroscopy in identification and antibiotic resistance profiling of lactic acid bacteria.
The study demonstrates the correlation between FT-IR spectral profiles and antibiotic resistance in lactic acid bacteria, highlighting the utility of these techniques for rapid resistance detection.
Genomic insights into the diversity, antimicrobial resistance and zoonotic potential of Campylobacter fetus across diverse hosts and geographies.
The study identified five AMR genes in Campylobacter fetus, including tet(O), tet(44), ant(6)-Ib, aph(3′)-III, and lnu(C), which confer resistance to tetracyclines, streptomycin, amikacin, and lincomycin. These genes were detected in human and animal isolates from various geographic regions.
Antimicrobial resistance pattern in Campylobacter strains isolated from both no-antibiotics-ever (NAE) and conventional broiler complexes: Genotypic and phenotypic characterization.
The study identified several AMR genes in Campylobacter strains from NAE and conventional broiler complexes, including bla OXA-61, bla OXA-184, tet (O), tet (O/32/O), and aph (3′)-III. These genes conferred resistance to various antibiotics such as tetracycline, cefoxitin, aztreonam, and gentamicin.
Genomic and Antimicrobial Resistance Analysis of an ST25 Streptococcus suis Strain Isolated from a Human in Zhejiang Province, China.
The study identified the tetracycline resistance gene tet(O) and the macrolide resistance gene erm(B) in an ST25 Streptococcus suis strain isolated from a human in Zhejiang Province, China.
Streptococcus suis Serotype 14: A Nonnegligible Zoonotic Population.
The study identified tetracycline resistance genes tet(O) and tet(40), as well as the MLS B resistance gene erm(B) in S. suis serotype 14 strains, highlighting their significant antimicrobial resistance profiles.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance and Virulence in Campylobacter spp. Isolated from Turkeys: Uncovering a Neglected Reservoir in the One Health Context.
The study identified several antimicrobial resistance genes, including tetO, gyrA (Thr-86-Ile mutation), ermB, Ery23S (A2075G mutation), and cmeB, in Campylobacter jejuni and C. coli isolates from turkeys, highlighting the presence of multidrug resistance and virulence factors.
Pangenomic Characterization of Campylobacter Plasmids for Enhanced Molecular Typing, Risk Assessment and Source Attribution.
The study identified the tet(O) gene as a significant tetracycline resistance marker in Campylobacter plasmids, particularly in pTet plasmids. It also revealed the presence of various AMR genes in different plasmid subgroups, highlighting the genetic diversity and resistance profiles of Campylobacter plasmids.
Population structure and antimicrobial resistance of Corynebacterium diphtheriae in Victoria, Australia.
The study identified multiple AMR genes and mutations in contemporary Corynebacterium diphtheriae isolates from Victoria, Australia, including pbp2m, erm(X), aph(3')-Ia, aph(6)-Id, aph(3'')-Ib, tet(W), tet(33), tet(O), cmx, sul1, dfrA15, and mutations in gyrA and rpoB. These genes and mutations confer resistance to various antimicrobials such as penicillin, erythromycin, gentamicin, tetracycline, chloramphenicol, sulfamethoxazole, trimethoprim, ciprofloxacin, and rifampicin.
Increase of macrolide resistance among Streptococcus pyogenes pharyngitis driven by a mef(A)-msr(D)/emm2-ST55 lineage in Portugal (2014-2019).
The study identifies the emergence of a mef(A)-msr(D) positive emm2-ST55 lineage as a major driver of increased macrolide resistance in Streptococcus pyogenes pharyngitis in Portugal between 2014 and 2019. It also characterizes various macrolide resistance genes including erm(A), erm(B), erm(T), tet(O), and tet(M) associated with different genetic lineages.
Phenotypic and genotypic characterization of ST103 serotype Ia Streptococcus agalactiae isolated from bovine mastitis in China.
The study identified tetracycline resistance genes tetO and tetM, as well as the macrolide resistance gene ermB in ST103 serotype Ia Streptococcus agalactiae isolates from bovine mastitis in China.
Multidrug-resistant Pseudomonas aeruginosa: Pathogenesis, resistance mechanisms, and novel therapeutic strategies.
The paper discusses the multidrug resistance mechanisms of Pseudomonas aeruginosa, including beta-lactamases, aminoglycoside modifying enzymes, efflux pumps, and mutations in porin genes. It highlights the role of these mechanisms in antibiotic resistance and the challenges they pose in treating infections.
Temporal dynamics of the resistome in gilts raised in an organic operation in which semen used for artificial insemination is the primary source of antimicrobial exposure.
The study identified several tetracycline, aminoglycoside, and MLS resistance genes in the fecal microbiome of gilts, with no significant increases in ARG abundance following exposure to semen extenders containing antibiotics.
Campylobacter Species Isolated From Wild Birds in Switzerland and Comparison to Isolates From Food and Human Origin.
Streptococcus suis avian expansion suggests shared antibiotic use drives host jumps.
The study identified multidrug-resistant S. suis lineages in birds, highlighting the role of shared antibiotic use in host jumps and the presence of resistance genes like ermB and tetO.
Commensal Clostridia in the preterm gut as reservoirs of antimicrobial resistance: susceptibility profiles, and resistance genes.
The study identifies tetracycline and clindamycin resistance genes (tet and erm) in various Clostridia species from preterm infants, highlighting their role as reservoirs of antimicrobial resistance.
A quantitative characterization of antibiotic resistance and its influencing factors in hospital wastewaters across Lebanon.
The study identifies multiple antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in hospital wastewaters across Lebanon, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, tetracyclines, sulfonamides, and glycopeptides.
Drug-resistant genes, virulence characteristics, and molecular typing of clindamycin-resistant Streptococcus agalactiae in late pregnancy.
The study identified several AMR genes and mutations in clindamycin-resistant S. agalactiae, including ermB, mreA, tetM, tetO, aph(3')-III, gyrA, and parC. Mutations in gyrA and parC were associated with levofloxacin resistance.
Tetracycline resistance determinants among streptococci of serological group G and L.
The study identifies tet(M) and tet(O) genes as the primary tetracycline and minocycline resistance determinants in streptococci of serological groups G and L.
Identification of the tetracycline resistance gene, tet(O), in Streptococcus pneumoniae.
Identification of the tetracycline resistance gene, tet(O), in Streptococcus pneumoniae.
Host mutations (miaA and rpsL) reduce tetracycline resistance mediated by Tet(O) and Tet(M).
Mutations in the miaA and rpsL genes reduce tetracycline resistance mediated by Tet(O) and Tet(M) in Salmonella typhimurium and Escherichia coli.
Nucleotide sequence analysis of tetracycline resistance gene tetO from Streptococcus mutans DL5., Identification of the tetracycline resistance gene, tet(O), in Streptococcus pneumoniae.
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