Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline-resistant ribosomal protection protein
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| tet(Q) | Card DatabaseResFinder Database | 2 | MINOCYCLINE, TETRACYCLINE +1 | Bacteroides fragilis +1 | - | 1994 | Z21523.1 | CAA79727.1 |
| Tet(Q) | Reference Gene CatalogResFinder DatabaseReslit | 44 | TETRACYCLINE, tetracycline +3 | Bifidobacterium longum, Prevotella intermedia +54 | North Carolina|Ohio, United States, Texas|Kenya, Venezuela, Dominican Republic, China, Alberta, Bangladesh|Sweden, Denmark, Europe, Minnesota, Shanxi Province, Canada, International Space Station, Belgium|Germany|Hungary|Slovenia|Turkey, India, Cambodia, North America, Japan, Bangladesh, Australia, Lebanon | 1992, 1993, 1994, 1999, 2001, 2005, 2007, 2009, 2013, 2015, 2016, 2018, 2019, 2021, 2022, 2023, 2024, 2025, 2026 | DQ093580.1, U73497.1 | CAA41552.1 |
| tetQ | Reslit | 60 | tetracycline, doxycycline | Bacteroides spp. +66 | human colon, Japan|Brazil, Japan, Spain, Cameroon, Minnesota, Europe, Southern Alberta, Canada, Michigan, USA, China, Amazon River|Kalamas River|Cam River|Cambridge|Amazon River Plume, California, Denmark, United Kingdom, Canada, North America|Asia|Europe|Australia|South America, Iran, Australia, Europe|USA|Portugal|Germany|Australia|China|India|Pakistan|Sweden|Colorado, Brazil, Norway, British Columbia, Canada|British Columbia, Mexico, Southern Germany|various, Belgium, Southern Malaysia, Brazil|Belgium, Asia|Europe, Slovak Republic, Europe|Africa|North America|South America|Asia|Oceania, Santa Catarina, Brazil|Brazil, China|Xinjiang, Europe|Austria|Hungary, North America|Canada, United States | 2001, 2007, 2008, 2010, 2013, 2014, 2015, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | X58717|Y08615|Z21523|M15332|X58285 | - |
| tet Q | Reslit | 4 | tetracycline, doxycycline | Enterococcus faecalis +2 | United States|Virginia, Guangdong Province, North America | 2011, 2021, 2023 | ERP146025 | - |
| TETQ | Reslit | 3 | tetracycline | Bacteroidetes +4 | Alberta, Canada | 2019, 2021, 2024 | PRJNA705824 | - |
| TetQ | Reslit | 1 | tetracycline | Bacteroides | Thailand | 2023 | - | - |
Mobile elements carrying ermF and tetQ genes in gram-positive and gram-negative bacteria.
Molecular ecology of tetracycline resistance: development and validation of primers for detection of tetracycline resistance genes encoding ribosomal protection proteins.
The study identified and characterized multiple tetracycline resistance genes encoding ribosomal protection proteins (RPPs) including tet(M), tet(O), tet(W), tet(Q), tet(S), tet(T), tetB(P), and otrA. These genes were detected in various bacterial species and environments, highlighting their prevalence and potential for horizontal gene transfer.
Evidence for extensive resistance gene transfer among Bacteroides spp. and among Bacteroides and other genera in the human colon.
The study shows extensive horizontal gene transfer of tetracycline resistance gene tetQ and erythromycin resistance genes ermF, ermG, and ermB among Bacteroides species and between Bacteroides and other genera in the human colon.
A Bacteroides tetracycline resistance gene represents a new class of ribosome protection tetracycline resistance.
A Bacteroides tetracycline resistance gene represents a new class of ribosome protection tetracycline resistance.
Development and Application of Real-Time PCR Assays for Quantification of Genes Encoding Tetracycline Resistance
The study developed and validated real-time PCR assays to quantify ten major classes of tetracycline resistance genes (tet) in microbiome samples, revealing significant differences in tet gene abundance between bovine and swine manures, with swine manures showing higher levels. Composting significantly reduced tet gene abundance.
Monitoring and Source Tracking of Tetracycline Resistance Genes in Lagoons and Groundwater Adjacent to Swine Production Facilities over a 3-Year Period
The study identified and characterized seven tetracycline resistance genes (tet(M), tet(O), tet(Q), tet(W), tet(C), tet(H), and tet(Z)) in lagoons and groundwater near swine production facilities over a 3-year period. These genes were consistently detected in groundwater and lagoon samples, with varying frequencies and concentrations depending on the location and sampling time.
Evaluating the effects of chlortetracycline on the proliferation of antibiotic-resistant bacteria in a simulated river water ecosystem.
The study found that high concentrations of chlortetracycline (CTC) selected for increased tetracycline resistance in aerobic bacterial populations, with a greater diversity of tet resistance genes detected in the high-CTC chemostat compared to low-CTC and control chemostats.
Bacteroides: the good, the bad, and the nitty-gritty.
The review discusses the role of Bacteroides species as commensals and pathogens, highlighting their complex relationships with the host, their resistance mechanisms, and their impact on health and disease.
Genetic tools for studying Capnocytophaga canimorsus.
The study describes the development of genetic tools for Capnocytophaga canimorsus, including the identification of functional resistance genes ermF, cfxA, and tetQ, which can be used as selection markers for plasmid maintenance in C. canimorsus and other Capnocytophaga species.
Antibiotic resistance genes in the vaginal microbiota of primates not normally exposed to antibiotics.
The study identified tetracycline resistance genes (tet(M), tet(W), tet(Q)) and erythromycin resistance genes (ermB, ermF) in the vaginal microbiota of primates not typically exposed to antibiotics, indicating the presence of antibiotic resistance genes in these animals despite limited antibiotic exposure.
Genetic analysis of mobile tetQ elements in oral Prevotella species.
The study characterizes the tetQ gene as a tetracycline resistance gene in oral Prevotella species and identifies mobile elements containing tetQ, including Tn6099 and Tn6100.
Antibiotic resistance in primary and persistent endodontic infections.
The study identified bla TEM-1, cfx A, tet M, tet W, and tet Q as the most prevalent antibiotic resistance genes in endodontic infections. bla TEM-1 was more prevalent in primary infections, while tet M remained unchanged after treatment. Vancomycin resistance genes were not detected.
PCR-based detection of resistance genes in anaerobic bacteria isolated from intra-abdominal infections.
The study identified several resistance genes, including cepA, cfiA, cfxA, tetQ, ermF, and mefA, in anaerobic bacteria isolated from intra-abdominal infections in Japan. A mutation in the gyrA gene was also found to confer resistance to fluoroquinolones.
Tetracycline resistance genes acquired at birth
The study identified tetracycline resistance genes (tet(M), tet(O), tet(Q), and tet(W)) in the microbiota of newborns and their mothers, highlighting differences in gene prevalence based on delivery mode.
Mechanisms of reduced susceptibility and genotypic prediction of antibiotic resistance in Prevotella isolated from cystic fibrosis (CF) and non-CF patients.
Antibiotic Multiresistance Analysis of Mesophilic and Psychrotrophic Pseudomonas spp. Isolated from Goat and Lamb Slaughterhouse Surfaces throughout the Meat Production Process.
The study identified multiple antibiotic resistance genes in Pseudomonas spp. isolated from slaughterhouse surfaces, including beta-lactamases (bla CTX, bla TEM), sulfonamide resistance (sulII), trimethoprim resistance (dfrD), tetracycline resistance (tetQ), erythromycin resistance (ereA), and chloramphenicol resistance (catA2).
Muddying the waters: a new area of concern for drinking water contamination in Cameroon.
The study identified the tetracycline resistance gene tetQ in drinking water samples from Maroua, Cameroon, indicating the presence of tetracycline-resistant bacteria in the area.
Diversity, distribution and quantification of antibiotic resistance genes in goat and lamb slaughterhouse surfaces and meat products.
The study identified various tetracycline, sulfonamide, and beta-lactam resistance genes in goat and lamb slaughterhouse surfaces and meat products, highlighting the prevalence of tet genes and their potential role in the spread of antibiotic resistance.
Characterization of a multidrug-resistant, novel Bacteroides genomospecies.
Metronidazole- and Carbapenem-Resistant Bacteroides thetaiotaomicron Isolated in Rochester, Minnesota, in 2014.
The study identifies multiple antimicrobial resistance genes in a metronidazole- and carbapenem-resistant Bacteroides thetaiotaomicron isolate, including nimD, cat, tetX, tetQ, ermF, and a novel beta-lactamase gene.
Periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased Dominican adults.
The study identified tetracycline resistance genes tet(Q), tet(32), and tet(W) in subgingival biofilms of Dominican adults with periodontal diseases. These genes were more prevalent in chronic periodontitis patients compared to healthy individuals.
Housefly Larva Vermicomposting Efficiently Attenuates Antibiotic Resistance Genes in Swine Manure, with Concomitant Bacterial Population Changes.
The study found that housefly larva vermicomposting significantly reduces the abundance of tetracycline resistance genes (tet(M), tet(O), tet(Q), tet(W)) and increases the abundance of sulfonamide resistance genes (sul1, sul2) in swine manure. It also observed changes in the bacterial community structure, with a significant decrease in the diversity and richness of bacteria.
The Bacterial Mobile Resistome Transfer Network Connecting the Animal and Human Microbiomes.
The study identifies mobile antibiotic resistance genes (ARGs) in bacterial genomes and explores their transfer networks between animal and human microbiomes, highlighting the role of phylogeny and ecology in shaping the mobile resistome.
Performance and microbial community variations of anaerobic digesters under increasing tetracycline concentrations.
The study found that the abundance of tetracycline resistance genes tetW and tetQ increased significantly in the reactor exposed to high tetracycline concentrations, indicating the development of tetracycline resistance in the microbial community.
Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
Four resistance genes (aac(6')-Ii, ermC, qacA, tetQ) were significantly more abundant in ICU patients than in healthy subjects, while catA and tetW were more abundant in healthy subjects.
Subtype-Specific Selection for Resistance to Fluoroquinolones but Not to Tetracyclines Is Evident in Campylobacter jejuni Isolates from Beef Cattle in Confined Feeding Operations in Southern Alberta, Canada.
The study identifies tetO as the primary tetracycline resistance gene in Campylobacter jejuni isolates from beef cattle and highlights gyrA mutations, particularly Thr86Ile, as a major cause of fluoroquinolone resistance.
Comparison of antimicrobial resistance genes in feedlots and urban wastewater.
The study identified various antimicrobial resistance genes in feedlots and urban wastewater, highlighting the prevalence of sulfonamide, tetracycline, macrolide, fluoroquinolone, and β-lactam resistance genes in different environments.
Various Profiles of tet Genes Addition to tet(X) in Riemerella anatipestifer Isolates From Ducks in China.
The study identified and characterized multiple tetracycline resistance genes, including tet(A), tet(B), tet(M), tet(O), tet(O/W/32/O), tet(Q), and tet(X), in Riemerella anatipestifer isolates from ducks in China. The tet(X) gene was found to be the primary mechanism of tetracycline resistance.
Effects of Ceftiofur and Chlortetracycline on the Resistomes of Feedlot Cattle.
The study found that tetracycline resistance genes, particularly tet(Q) and tet(40), were significantly enriched in cattle fed chlortetracycline. β-lactam resistance genes such as bla_CFX-A6 and bla_ACI-1 were also identified, but no significant changes were observed in their relative abundances. Aminoglycoside resistance genes showed an increase despite no aminoglycoside administration.
Bifidobacterial Dominance of the Gut in Early Life and Acquisition of Antimicrobial Resistance.
High levels of Bifidobacterium in early life are associated with reduced levels of antimicrobial resistance (AMR) in the gut microbiome. Specifically, the gene ermX, encoding a 23S rRNA methyltransferase, was found to be significantly enriched in high-Bifidobacterium samples and is associated with resistance to macrolides, lincosamides, and streptogramin B.
Pilot Safety Evaluation of a Novel Strain of Bacteroides ovatus.
The study identified several antibiotic resistance genes in Bacteroides ovatus ELH-B2, including those conferring resistance to tetracycline, erythromycin, aminoglycosides, macrolides, and other antibiotics. These genes were validated through minimum inhibitory concentration (MIC) tests.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
Manure and Doxycycline Affect the Bacterial Community and Its Resistome in Lettuce Rhizosphere and Bulk Soil.
The study identified the tetracycline resistance gene tetA(P) as being highly enriched in manure-treated soil and rhizosphere, particularly in doxycycline-treated bulk soil, indicating its potential as a marker for soil contamination by antibiotic-resistant bacteria and antibiotics.
First Report of Integrative Conjugative Elements in Riemerella anatipestifer Isolates From Ducks in China.
The study reports the first identification of integrative conjugative elements (ICEs) in Riemerella anatipestifer isolates from ducks in China. It characterizes two ICEs, ICE Ran RCAD0133-1 and ICE Ran RCAD0179-1, and identifies a tetracycline resistance gene, tetQ, carried by ICE Ran RCAD0179-1.
Comparative diversity of microbiomes and Resistomes in beef feedlots, downstream environments and urban sewage influent.
The study identified several tetracycline, macrolide, aminoglycoside, beta-lactam, sulfonamide, mercury, and biocide resistance genes in beef feedlots, catch basin water, soil, and urban sewage influent. Tetracycline resistance was predominant in beef production systems, while urban sewage influent showed a diverse resistome with resistance to multiple antimicrobial classes.
Characterization of Discriminatory Antimicrobial Resistance Genes in Aquatic Environments Using Machine Learning
The study identifies discriminatory antibiotic resistance genes (ARGs) using an extremely randomized tree (ERT) algorithm, highlighting genes like sul1, tet(W), and ermB as significant markers for differentiating resistomes across various aquatic environments.
The fecal resistome of dairy cattle is associated with diet during nursing.
The study identified various antimicrobial resistance genes (ARGs) in the fecal microbiota of dairy calves, highlighting the association between diet and the resistome. Key genes include ermB, lnuC, mefA, tet32, tet40, tetO, tetQ, tetW, and optrA, which confer resistance to macrolides, lincosamides, streptogramin B, and tetracyclines, as well as oxazolidinones and phenicols.
Complete hybrid genome assembly of clinical multidrug-resistant Bacteroides fragilis isolates enables comprehensive identification of antimicrobial-resistance genes and plasmids.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant Bacteroides fragilis isolates, including cfiA, nim, erm, tet, and others, using hybrid genome assembly and ABRicate screening.
Complete hybrid genome assembly of clinical multidrug-resistant Bacteroides fragilis isolates enables comprehensive identification of antimicrobial-resistance genes and plasmids.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant Bacteroides fragilis isolates, including cfiA, nim, erm, tet, and others, using hybrid genome assembly and ABRicate screening.
Metagenomic identification of severe pneumonia pathogens in mechanically-ventilated patients: a feasibility and clinical validity study.
The study identified several AMR genes using Nanopore sequencing, including mecA, blaTEM-4, blaTEM-112, blaTEM-157, blaACT-5, oqxB, tetC, ermA, erm (33), tet38, ant(4′)-lb, tetK, tetQ, sul1, dfrA, acrF, parE, mfd, mphA, aadA5, vgaC, blaACT-5, blaACT-14, mefA, mel, tetX, tetM, isaC, and aadA5, which conferred resistance to various antibiotics such as methicillin, ticarcillin, ceftazidime, erythromycin, clindamycin, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and levofloxacin.
Comprehensive analysis of chromosomal mobile genetic elements in the gut microbiome reveals phylum-level niche-adaptive gene pools.
The study identifies 5,219 putative chromosomal mobile genetic elements (MGEs) in the gut microbiome, highlighting their role in transferring niche-adaptive genes, including antibiotic resistance genes, bile salt detoxification genes, and genes involved in mucus degradation and sporulation.
Resistance to change: AMR gene dynamics on a commercial pig farm with high antimicrobial usage.
The study identified multiple AMR genes, including tetB, tetQ, ermA, ermB, and dfrA1, which were associated with tetracycline, macrolide, and trimethoprim resistance in porcine fecal samples. These genes were found to be prevalent and diverse, with no significant changes in their abundance despite antimicrobial treatments.
Identification and characterization of invasive multi-drug-resistant (MDR) Bacteroides genomospecies in Canada.
The study identifies a novel multidrug-resistant Bacteroides genomospecies carrying the nimE gene associated with metronidazole resistance, along with other resistance genes such as tetQ, cfiA13, and erm(F).
Early Inoculation of Microbial Suspension in Suckling Piglets Affects the Transmission of Maternal Microbiota and the Associated Antibiotic Resistance Genes.
The study shows that early inoculation of microbial suspensions affects the transmission of maternal microbiota and the associated antibiotic resistance genes (ARGs) in piglets. Specific ARGs such as aadE_2, aphA3, ermB, lnuB, vanTG, tetQ, tnpA, mpmB, lnuC, and tetW were found to be influenced by the inoculation of microbial suspensions S1 and S2.
The distribution of antibiotic resistance genes in chicken gut microbiota commensals.
The study identified various tetracycline resistance genes including tet(W), tet(Q), tet(32), tet(O), tet(44), tetA(P), and tetB(P) in chicken gut microbiota commensals, highlighting their distribution across different bacterial families.
Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins.
The study identifies several ribosomal protection protein (RPP) genes, including tet(M), tet(O), tet(W), tet(Q), tetB(P), and otr(A), that can confer high-level tetracycline resistance in E. coli. However, expression of these genes often comes with fitness costs, and certain mutations in tRNA genes (argW and proL) or the hns gene can mitigate these costs.
Genomic Background and Phylogeny of cfiA-Positive Bacteroides fragilis Strains Resistant to Meropenem-EDTA.
The study identifies two new metallo-beta-lactamase genes, cfiA14b and cfiA28, in Bacteroides fragilis strains resistant to meropenem-EDTA. Additionally, various other AMR genes such as aadS, aac(3'), ermF, lnu(AN2), vatA, mef(En2), tetX, tetQ, cat, bexA, bexB, qacE, cusR, mexAB-oprM, mexJK-oprM, mexXY-oprM, acrEF-tolC, and mdtEF-tolC were characterized.
Genomic diversity and molecular epidemiology of Pasteurella multocida.
This study identified several antimicrobial resistance genes in Pasteurella multocida, including aminoglycoside, beta-lactam, tetracycline, macrolide, and sulfonamide resistance genes, highlighting the diverse resistance mechanisms present in this pathogen.
Antibiotic resistance pattern of Bacteroides fragilis isolated from clinical and colorectal specimens.
The study identified high resistance rates in Bacteroides fragilis isolates, particularly to penicillin G, tetracycline, clindamycin, and cefoxitin. Key resistance genes included tetQ, ermF, cepA, cfxA, and cfiA.
Evaluation of Metagenomic-Enabled Antibiotic Resistance Surveillance at a Conventional Wastewater Treatment Plant.
The study evaluated the resistome in a conventional wastewater treatment plant, identifying several antibiotic resistance genes (ARGs) such as bla OXA-210, bla OXA-212, bla OXA-309, bla OXA-333, qnr S2, sul 1, sul 2, erm B, aac (6′)-Ib7, aac (6′)-Ib8, mph D, msr E, ade J, ade K, mex K, mtr A, sme R, oqx B, qac H, and others. These genes were found to confer resistance to various antibiotics, highlighting the importance of monitoring ARGs in wastewater treatment processes.
Effects of Ursolic Acid on Intestinal Health and Gut Bacteria Antibiotic Resistance in Mice.
Ursolic acid reduced the expression of tetracycline resistance genes in the gut microbiota of antibiotic-exposed mice.
Antibiotic resistance genes in layer farms and their correlation with environmental samples.
The study identified and quantified 13 antibiotic resistance genes (ARGs) in layer manure, layer manure fertilizer, and soil samples from Guangdong Province, highlighting the high prevalence and abundance of these genes, particularly ermB, tetA, and sul2, and their potential environmental impact.
Resistome Analysis in the Digestive Tract of Food-Producing Animals
The study identifies tetW and mefA as highly expressed tetracycline and macrolide resistance genes in the rumen of beef cattle, highlighting their significance in the resistome of food-producing animals.
Genomic diversity and antimicrobial resistance of Prevotella species isolated from chronic lung disease airways.
The study identified ermF, tetQ, and cfxA as key AMR genes in Prevotella species, showing strong correlations with resistance to azithromycin, clindamycin, doxycycline, and ceftazidime. All isolates were resistant to tobramycin.
Extensive metagenomic analysis of the porcine gut resistome to identify indicators reflecting antimicrobial resistance.
The study identified 1295 open reading frames recognized as antimicrobial resistance protein-coding genes in porcine gut microbiomes, highlighting tetracycline, aminoglycoside, and MLS resistance as predominant. Key ARGs like tet(W/N/W), APH(3')-IIIa, and ErmB were found to be highly prevalent and associated with resistance to specific antibiotics.
Evaluating the potential of third generation metagenomic sequencing for the detection of BRD pathogens and genetic determinants of antimicrobial resistance in chronically ill feedlot cattle.
The study identified various antimicrobial resistance genes (ARGs) in metagenomic sequencing data from chronically ill feedlot cattle, including genes conferring resistance to beta-lactams, aminoglycosides, macrolides, phenicols, tetracyclines, and trimethoprim. Notably, tetH was the most frequently detected resistance gene, and several ARGs were found to be associated with integrative and conjugative elements (ICEs).
Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches.
The study identifies several AMR genes and mutations associated with resistance to various antibiotics in wastewater environments, highlighting the role of these genes in the spread of antimicrobial resistance.
The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs.
The study identified ermG as a gene that increased in abundance in the feces of treated pigs compared to those that did not receive post-PRRS antimicrobials, indicating its role in macrolide, lincosamide, and streptogramin B resistance.
Exploring the Bacteriome and Resistome of Humans and Food-Producing Animals in Brazil.
The study identified various antimicrobial resistance genes (ARGs) in humans and food-producing animals in Brazil, including novel carbapenemase-encoding genes such as blaAIM-1, blaCAM-1, blaGIM-2, and blaHMB-1, which were not previously reported in Latin America. Other significant ARGs included aac(6')-Ib-cr, ermF, ermB, ermG, tetO, tetQ, tetW, qnrB10, qnrB19, qnrD1, and crpP.
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
The study found that prolonged amoxicillin treatment leads to an increase in the abundance and diversity of antimicrobial resistance genes (ARGs) in the gut microbiome, particularly beta-lactamase genes such as cfxA and its variants, as well as tetracycline and macrolide resistance genes.
Genomics of Tenacibaculum Species in British Columbia, Canada.
The study identified tetracycline resistance genes (tetQ, tetR) and vancomycin resistance genes (vanT, vanX, vanY) in various Tenacibaculum species isolated from Atlantic salmon in British Columbia, Canada.
Root canal microbiota as an augmented reservoir of antimicrobial resistance genes in type 2 diabetes mellitus patients.
The study identifies that root canal microbiota in T2DM patients harbor a higher prevalence of antimicrobial resistance genes (ARGs) compared to non-diabetic patients, particularly for tetW, tetM, ermB, ermC, cfxA, and tetQ.
Metagenomic analysis reveals patterns and hosts of antibiotic resistance in different pig farms.
The study identified various antibiotic resistance genes (ARGs) in pig manure samples from different regions of Shanxi, China, highlighting the prevalence of tetracycline, aminoglycoside, macrolide, and phenicol resistance genes. Key ARGs included tet(W), tet(40), tet(Q), erm(B), erm(F), mef(A), aph(3')-III, ant(6)-Ia, cfr(C), floR, blaACI-1, optrA, cat, cfxA4, cfxA5, blaCTX-M-105, blaCTX-M-65, fexB, erm(T), mdf(A), and ole(B).
Correlations among Antibiotic Resistance Genes, Mobile Genetic Elements and Microbial Communities in Municipal Sewage Treatment Plants Revealed by High-Throughput Sequencing.
The study identifies various tetracycline resistance genes (tetC, tetE, tetG, tetM, tetO, tetQ, tetW, tetX), sulfonamide resistance gene (sulI), aminoglycoside resistance genes (ant(2')-Ia, ant(3')-Ia, aph(6')-Id, aph(33')-Ib, aac(6')-Ib), beta-lactam resistance genes (blaGES, blaVEB), chloramphenicol resistance gene (catB3), MLS resistance genes (ereA, ermB), and multidrug resistance genes (acrB, mexB, mexF) in municipal sewage treatment plants, highlighting their association with mobile genetic elements and microbial communities.
Longitudinal study of the short- and long-term effects of hospitalisation and oral trimethoprim-sulfadiazine administration on the equine faecal microbiome and resistome.
Oral trimethoprim-sulfadiazine (TMS) administration leads to a significant and long-lasting increase in the relative abundance of resistance genes sul2, tetQ, ant6-1a, aph(3"-lb, and lnuC in the equine faecal microbiome.
Case Report: The effect of intravenous and oral antibiotics on the gut microbiome and breath volatile organic compounds over one year.
The study identified several resistance genes in Bacteroides coprophilus and Bacteroides dorei, including adeF, ermF, tetQ, ermG, and a carbapenem resistance gene, highlighting the impact of antimicrobial exposure on the gut microbiome's resistance profiles.
The oral microbiota is a reservoir for antimicrobial resistance: resistome and phenotypic resistance characteristics of oral biofilm in health, caries, and periodontitis.
The study identified various antimicrobial resistance genes (ARGs) in the oral microbiota, including mefA, msrD, ermB, ermF, cfxA, blaCSP(1), tetM, tetQ, and pgpB, which confer resistance to antibiotics such as erythromycin, azithromycin, penicillin, ampicillin, tetracycline, and colistin. These genes were found in multiple bacterial species and were associated with different resistotypes in healthy, caries, and periodontitis groups.
Impact of immigration on antibiotic resistance genes in activated sludge: A study using digital droplet PCR and amplicon sequencing
The study reveals that immigration of influent wastewater into activated sludge leads to an increase in the abundance of over 70% of the quantified antibiotic resistance genes (ARGs). Specific ARGs such as blaTEM, blaMOX, qnrS, qnrB, mphE, dfrA, tetO, tetQ, tetE, marR, msrD, robA, qacL, blaOXA, and ereA were found to increase in abundance with immigration, indicating the impact of influent immigration on the persistence of AMR in wastewater treatment plants.
Cefquinome shows a higher impact on the pig gut microbiome and resistome compared to ceftiofur.
Cefquinome treatment led to a significant increase in several antimicrobial resistance genes, including tetQ, mel, ErmF, CfxA6, lsaB, and tet(40), whereas ceftiofur primarily increased tetQ and tet(40). The resistome returned to baseline levels within 21 days post-treatment.
Metaproteomic Analysis of Gut Resistome in the Cecal Microbiota of Fattening Pigs Raised without Antibiotics.
The study identified several AMR genes, including APH(3'), CTX-M-14, ArnA, MdtL, CatB2, TetQ, TetR, Cas1, and Cas9, in the cecal microbiota of pigs raised with and without antibiotics. These genes were associated with resistance to aminoglycosides, beta-lactams, polymyxin, tetracycline, and other antibiotics.
The gut microbiome and resistome of conventionally vs. pasture-raised pigs.
The study found that conventionally raised pigs had a significantly higher abundance of antimicrobial resistance genes (ARGs) compared to pasture-raised pigs, particularly for aminoglycosides, beta-lactams, macrolides-lincosamides-streptogramin B, and tetracyclines. Several ARGs, including aph(3')-IIIa, erm(B), erm(X), tet(Q), tet(36), tet(W/N/W), blaOXA-193, and cfxA2, were identified as being more prevalent in the gut microbiome of conventionally raised pigs.
Social demographics determinants for resistome and microbiome variation of a multiethnic community in Southern Malaysia.
The study identified 1038 antibiotic resistance genes from 200 community participants, highlighting the association of resistome profiles with lifestyle and environmental factors, particularly emphasizing the role of Escherichia coli in the resistome dynamics.
Isolation and Characterization of the Acadevirus Members BigMira and MidiMira Infecting a Highly Pathogenic Proteus mirabilis Strain.
The study identifies multiple antibiotic resistance genes in the highly pathogenic Proteus mirabilis strain MCS, highlighting its multidrug-resistant profile. Key genes include tetA, aac(6')-Iq, aac(6')-Ib', aadA, dfrA1, blaOXA-9, blaCTX-M-2, vat, catA2, sul1, qacEdeltal, tetQ, blaTEM-135, aadA2, aph(3')-Ia, aph(6)-Id, aph(3'')-lb, and sulI.
Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes.
Five novel bacterial species were isolated from the International Space Station (ISS) and characterized. These species, Arthrobacter burdickii, Leifsonia virtsii, Leifsonia williamsii, Paenibacillus vandeheii, and Sporosarcina highlanderae, were identified through phylogenomic, phenotypic, and functional analyses. Their genomes were sequenced, and they were distinguished from known species using ANI and dDDH values, as well as gyrB gene sequence similarities.
Development of a portable on-site applicable metagenomic data generation workflow for enhanced pathogen and antimicrobial resistance surveillance.
The study characterizes several antimicrobial resistance genes, including tet(W), tet(Q), mdf(A), erm(B), lsa(A), and aac(6')-Iaa, through the use of a spiked-in mock community and long-read sequencing.
Using 16S rDNA and metagenomic sequencing technology to analyze the fecal microbiome of children with avoidant/restrictive food intake disorder.
The study identified several antibiotic resistance genes in the fecal microbiome of children with ARFID, including vanT, tetQ, adeF, and ermF, with ermF showing significantly higher abundance in the ARFID group compared to healthy controls.
Altered microbiota, antimicrobial resistance genes, and functional enzyme profiles in the rumen of yak calves fed with milk replacer.
The study identified 138 antimicrobial resistance genes (ARGs) in the rumen of yak calves, with tetracycline resistance being the most prevalent. The study also found that feeding milk replacer (MR) altered the rumen resistome and microbiota, increasing the abundance of Prevotella and affecting the functional enzyme profiles.
Elimination of antibiotic-resistant bacteria and resistance genes by earthworms during vermifiltration treatment of excess sludge.
The study demonstrates that earthworms significantly reduce antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in sludge through mechanisms involving coelomic fluid and gut activity, with notable reductions in tetracycline and sulfonamide resistance genes.
Effects of Neolamarckia cadamba leaves extract on microbial community and antibiotic resistance genes in cecal contents and feces of broilers challenged with lipopolysaccharides.
The study found that Neolamarckia cadamba leaves extract (NCLE) reduced the abundance of antibiotic resistance genes (ARGs) in cecal contents of lipopolysaccharide (LPS)-induced broilers by maintaining microbial balance.
Metagenomics reveals the temporal dynamics of the rumen resistome and microbiome in goat kids.
The study identified numerous antibiotic resistance genes (ARGs) in the rumen of goat kids, highlighting the dynamic nature of the resistome influenced by age and diet. Key ARGs included RPOB, GYRA, GYRBA, ROB, MDTF, ACRF, ACRB, MGTA, MLS23S, TUFAB, TET44, TET32, APH2-DPRIME, SAT, BRO, TETQ, ERMF, NIMJ, ACI, MEFA, RRSC, RRSH, CAP16S, TETX, LNUC, TETW, TETO, and TET40, which were associated with resistance to various antibiotics such as drugs, MLS, tetracyclines, and others.
A novel conjugative transposon carrying an autonomously amplified plasmid.
The study identifies a novel conjugative transposon, CTn214, which carries the tetracycline resistance gene tetQ. The transposon exhibits an autonomously amplified plasmid-like form that remains active regardless of tetracycline exposure, offering insights into the persistence of antibiotic resistance mechanisms in Bacteroides fragilis.
Airway "Resistotypes" and Clinical Outcomes in Bronchiectasis.
The study identifies distinct 'resistotypes' in bronchiectasis patients, showing associations with clinical outcomes, geographic origin, and the underlying microbiome. Targeted eradication of P. aeruginosa leads to a shift from a less favorable resistotype to a more favorable one.
Gut diversity and the resistome as biomarkers of febrile neutropenia outcome in paediatric oncology patients undergoing hematopoietic stem cell transplantation.
The study identifies several antibiotic-resistance genes associated with febrile neutropenia in pediatric oncology patients undergoing hematopoietic stem cell transplantation, including msr(C), dfrG, erm(T), VanHAX, aac(6')-Ib, aph(3')-III, ant(6)-Ia, and aac(6')-Ii.
Detection of the antibiotic resistance genes content of intestinal Bacteroides, Parabacteroides and Phocaeicola isolates from healthy and carbapenem-treated patients from European countries.
The study identified and compared the prevalence of antibiotic resistance genes in intestinal Bacteroides, Parabacteroides and Phocaeicola isolates from healthy and carbapenem-treated patients in European countries, highlighting differences in gene carriage between gut microbiota and clinical strains.
Deeper Exploration of Gut Microbiome: Profile of Resistome, Virome and Viral Auxiliary Metabolic Genes of Three Ethnic Indian Groups.
The study identified tetracycline resistance genes tet(W), erm(F), and tet(Q) in the gut microbiomes of three Indian ethnic groups, with higher burdens observed in the Khargone and Ladakh groups compared to the Jaisalmer group.
Faecal microbiota and cytokine profiles of rural Cambodian infants linked to diet and diarrhoeal episodes.
The study identified antimicrobial resistance genes such as erm(X), tet(O), tet(O/23/O), tet(Q), and tet(W) in Bifidobacterium isolates from Cambodian infants, highlighting the presence of resistance mechanisms in the gut microbiota.
Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome.
The study found that doxy-PEP use over 6 months significantly increased the proportion and expression of tetracycline resistance genes in the gut microbiome, with no significant changes in other antibiotic resistance gene classes.
Segatella clades adopt distinct roles within a single individual's gut.
The study identifies cfxA6 and tetQ as intrinsic antibiotic resistance genes in Segatella clades, demonstrating resistance to ampicillin and tetracycline, respectively.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Evaluation of the resistome and gut microbiome composition of hospitalized patients in a health unit of southern Brazil coming from a high animal husbandry production region.
The study identified a high prevalence of aminoglycoside and tetracycline resistance genes, including aph(3')-IIIa, ermB, mcr-1, qnrB19, and tetQ, in hospitalized patients from a high animal husbandry region. Unique resistance genes and mutations, such as dfrF and gyrB, were noted at discharge.
Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.
This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.
Alistipes Bacteremia in Older Patients with Digestive and Cancer Comorbidities, Japan, 2016-2023.
The study identified several antimicrobial resistance genes in Alistipes strains, including adeF, tet(Q), cfxA3, cfxA4, and ermG, which confer resistance to various antibiotics such as minocycline, cefuroxime, and clindamycin.
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.
Potential pathogens and antimicrobial resistance genes in household environments: a study of soil floors and cow dung in rural Bangladesh.
The study identified multiple antimicrobial resistance genes (ARGs) in soil floors and cow dung samples from rural Bangladesh, including sul1, tet(Q), ermF, mexF, and cfxA2, which confer resistance to sulfonamides, tetracycline, macrolides, lincosamides, streptogramins, and cephalosporins.
Comprehensive genome catalog analysis of the resistome, virulome and mobilome in the wild rodent gut microbiota.
The study identified numerous antibiotic resistance genes (ARGs) in the gut microbiota of wild rodents, including genes conferring resistance to elfamycin, tetracycline, and glycopeptides. Notable ARGs include Cdif_EFTu_ELF, Ecol_EFTu_KIR, Efac_EFTu_GE2A, Saur_fusA_FA, and Cdif_rpoB_RIF, which were found to be widely distributed among rodent gut microbiomes.
Application of MALDI-TOF MS and FT-IR spectroscopy in identification and antibiotic resistance profiling of lactic acid bacteria.
The study demonstrates the correlation between FT-IR spectral profiles and antibiotic resistance in lactic acid bacteria, highlighting the utility of these techniques for rapid resistance detection.
Genomic analysis reveals two dominant strains of Ornithobacterium rhinotracheale in Austria and Hungary with distinct multidrug resistance profiles.
The study identifies distinct multidrug resistance profiles in two dominant strains of Ornithobacterium rhinotracheale from Austria and Hungary, highlighting the presence of resistance genes such as ermF, orr, tetX, and tetQ.
Dietary impact on the gut resistome: western diet independently increases the prevalence of antibiotic resistance genes within the gut microbiota.
The study shows that a western diet independently increases the prevalence of antibiotic resistance genes (ARGs) in the gut microbiota without antibiotic exposure. Specifically, ARGs such as ErmG, CfxA2, tetQ, lnuC, and mefA were found to be significantly enriched in the gut microbiota of mice fed a western diet.
Natural Microbiota of Dogs and Cats as a Source and Vector of Resistance Genes-Clinical Significance.
The study identifies tetracycline resistance genes (tet(Q), tet(A)), macrolide resistance genes (mef(A), erm(B), erm(F)), and lincosamide resistance gene (lnu(C)) in the natural microbiota of dogs and cats, highlighting their potential as vectors for antimicrobial resistance.
CapSeq for Surveillance in Environmental Samples
The study demonstrates the effectiveness of CapSeq in detecting and genotyping bacterial pathogens and antibiotic resistance genes in bovine respiratory disease (BRD) samples, highlighting the presence of various resistance genes such as bla-TEM, bla-ROB, tetM, tetQ, tetS, tetH, tetX, floR, rrs, and rrl.
Lignocellulose degradation capabilities and distribution of antibiotic resistance genes and virulence factors in Clostridium from the gut of giant pandas.
The study identified 19 antibiotic resistance genes (ARGs) in Clostridium species from the gut of giant pandas, including glycopeptide resistance genes (vanG, vanH, vanR, vanT, vanW, vanX, vanY), tetracycline resistance genes (tet(Q), tetA(P), tetB(P)), multidrug resistance genes (cplR, sdrM, ermQ), and disinfectant resistance genes (qacG, qacJ).
Antimicrobial resistance is widespread among intestinal and extra-intestinal Bacteroides fragilis strains.
The study reveals that both intestinal and extra-intestinal B. fragilis strains possess comparable resistance gene profiles and antimicrobial susceptibility patterns, suggesting that intestinal strains serve as a reservoir of clinically relevant resistance determinants.
Temporal dynamics of the resistome in gilts raised in an organic operation in which semen used for artificial insemination is the primary source of antimicrobial exposure.
The study identified several tetracycline, aminoglycoside, and MLS resistance genes in the fecal microbiome of gilts, with no significant increases in ARG abundance following exposure to semen extenders containing antibiotics.
Cervicovaginal microbiome composition and absolute quantity are associated with pelvic inflammatory disease.
The study found that PID cases were associated with higher abundance of G. vaginalis and other CST IV organisms, while controls had higher levels of L. crispatus. No specific AMR genes were characterized in this paper.
A quantitative characterization of antibiotic resistance and its influencing factors in hospital wastewaters across Lebanon.
The study identifies multiple antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in hospital wastewaters across Lebanon, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, tetracyclines, sulfonamides, and glycopeptides.
Elucidation of population-based bacterial adaptation to antimicrobial treatment by single-cell sequencing analysis of the gut microbiome of a hospital patient.
The study identified 29 ARG subtypes across eight types in 13 known, five unknown, and 18 unclassified species, highlighting the complex and dynamic nature of antimicrobial resistance in the gut microbiome. Notably, the cfr(C) gene was detected in 11 bacterial species following antimicrobial treatment, with mutation patterns characterized in several species.
Wilson's disease-associated gut dysbiosis: novel insights into microbial functional alterations, virulence changes, and resistance markers.
The study identified several antibiotic resistance genes (ARGs) associated with Wilson's disease, including tetQ, ermB, cfxA6, Bbif_ileS_MUP, and Bado_rpoB_RIF, which were found to be differentially abundant in patients compared to healthy controls.
Sequencing of a tet(Q) gene isolated from Bacteroides fragilis 1126.
Sequencing of a tet(Q) gene isolated from Bacteroides fragilis 1126.
Evidence for natural horizontal transfer of tetQ between bacteria that normally colonize humans and bacteria that normally colonize livestock.
Evidence for natural horizontal transfer of tetQ between bacteria that normally colonize humans and bacteria that normally colonize livestock.
Evidence for natural horizontal transfer of tetQ between bacteria that normally colonize humans and bacteria that normally colonize livestock., A Bacteroides tetracycline resistance gene represents a new class of ribosome protection tetracycline resistance., Sequencing of a tet(Q) gene isolated from Bacteroides fragilis 1126.
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