Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
major facilitator superfamily (MFS) antibiotic efflux pump
Overview
Environmental macrolide-lincosamide-streptogramin and tetracycline resistant bacteria.
The paper discusses the characterization of environmental macrolide-lincosamide-streptogramin (MLS) and tetracycline resistance genes, highlighting the diversity and distribution of these genes in environmental bacteria. It identifies several MLS resistance genes such as erm(H), erm(I), erm(N), and others, as well as tetracycline resistance genes like tetA(P), tet(V), and tet(X).
Tetracycline resistance and presence of tetracycline resistance determinants tet(V) and tap in rapidly growing mycobacteria from agricultural soils and clinical isolates.
The study identified the presence of tetracycline resistance genes tet(V) and tap in both soil and clinical isolates of rapidly growing mycobacteria. These genes encode efflux pumps that contribute to tetracycline resistance. The study highlights the importance of intrinsic efflux pumps in tetracycline resistance in mycobacteria.
The role of transport mechanisms in mycobacterium tuberculosis drug resistance and tolerance.
The paper discusses the role of transport mechanisms, particularly efflux pumps, in Mycobacterium tuberculosis drug resistance and tolerance, highlighting the importance of efflux pump activity in reducing drug susceptibility.
Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment.
The study identified the erythromycin resistance methylase gene erm in Mycobacterium obuense, explaining its resistance to clarithromycin, and the tetracycline resistance gene tet(V) in M. obuense and M. mucogenicum.
Chicken Manure and Mushroom Residues Affect Soil Bacterial Community Structure but Not the Bacterial Resistome When Applied at the Same Rate of Nitrogen for 3 Years.
The study identified several antibiotic resistance genes (ARGs) in chicken manure, mushroom residues, and heat-treated chicken manure, highlighting the impact of different organic manures on the soil resistome. Key findings include the enrichment of specific ARGs such as aadE, aadD, qacE1, qacH, lnuA, vatE, and tetL in soils treated with various manures, indicating the potential for ARG transfer through manure application.
Genomic insights into the antibiotic resistance pattern of the tetracycline-degrading bacterium, Arthrobacter nicotianae OTC-16.
The study identifies several antibiotic resistance genes in Arthrobacter nicotianae OTC-16, including ant2ia, sul1, tet33, cml_e8, and tetV, which confer resistance to various antibiotics such as tetracyclines, sulfonamides, aminoglycosides, and chloramphenicol.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Protistan predation selects for antibiotic resistance in soil bacterial communities.
The study found that increasing protistan predation pressure significantly enhances the abundance and diversity of antibiotic resistance genes (ARGs) in soil bacterial communities, particularly multidrug efflux pump genes (oprJ, ttgB), tetracycline efflux pump gene (tetV), aminoglycoside resistance gene (aadA1), beta-lactamase genes (blaTEM, ampC-04), and glycopeptide resistance genes (vanWG, vanC-03).
Soil management strategies drive divergent impacts on pathogens and environmental resistomes.
The study found that organic soil management practices, involving composted poultry manure, led to higher abundance of antimicrobial resistance genes (ARGs) and metal resistance genes (MRGs) compared to non-organic practices. However, these genes were less diverse and less mobile, indicating a reduced risk of horizontal gene transfer. The study highlights the importance of evaluating gene mobility and management context when assessing AMR hazards.
Molecular cloning and functional analysis of a novel tetracycline resistance determinant, tet(V), from Mycobacterium smegmatis.
The study identified and characterized a novel tetracycline resistance gene, tet(V), from Mycobacterium smegmatis, which encodes a hydrophobic 44-kDa protein that confers resistance to tetracycline through an energy-dependent efflux mechanism.
Molecular cloning and functional analysis of a novel tetracycline resistance determinant, tet(V), from Mycobacterium smegmatis.
Molecular cloning and functional analysis of a novel tetracycline resistance determinant, tet(V), from Mycobacterium smegmatis.
Molecular cloning and functional analysis of a novel tetracycline resistance determinant, tet(V), from Mycobacterium smegmatis.
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