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Explore antimicrobial resistance genes from the literature
tetracycline resistance ribosomal protection protein Tet(W)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Tet(W) | Reference Gene CatalogResFinder DatabaseReslit | 118 | TETRACYCLINE, MINOCYCLINE +6 | Bifidobacterium sp. ISO3519 +125 | Iowa, North Carolina|Ohio, United States, United Kingdom, Texas|Kenya, China, Italy, United States|USA, Venezuela, Denmark|Europe, Dominican Republic, Spain, global|Europe|Belgium, Europe, Lake Geneva, Switzerland, Spain|Canada|Brazil|Thailand, Alberta, USA|France|Portugal|China|Brazil|Germany|Sweden|Italy|Spain|Denmark|Japan|Korea|Europe|Asia|North America, Lake Geneva, Switzerland|Vidy Bay, Lake Geneva, Amazon River|Kalamas River|Cam River|Cambridge|Amazon River Plume, Japan, Global, Europe|Czech Republic|England/Wales|Sweden|Japan, Pacific region|Hawaii, Cairo, Egypt|Egypt, China|United States of America|United Kingdom|Canada|Spain|Netherlands|France|Germany|Denmark|Europe|North America, China|Guangdong Province, China, Minnesota, global|Greece|India|Morocco|Pakistan, Ghana, Chiang Mai province, Northern Thailand|Thailand, Poland, Korea, Shanxi Province, Germany|Vietnam, Taiwan, Bulgaria, India, Cambodia, North America, China|United States|United Kingdom|Canada|Germany|Brazil|Australia, Hubei Province, China, China|Denmark, France, Victoria, Australia, Australia | 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AF202986.1 | AAL30847.1 |
| tet(W) | Card DatabaseResFinder Database | 2 | MINOCYCLINE, TETRACYCLINE +1 | Butyrivibrio fibrisolvens +1 | - | 2006 | AJ222769.3 | CAA10975.1 |
| tet W | Reslit | 4 | tetracycline, doxycycline | Enterococcus faecalis +1 | Italy, Colombia, Europe | 2011, 2020, 2021 | - | - |
| tetW | Reslit | 63 | tetracycline, oxytetracycline +2 | Lawsonia +68 | Maine|New Hampshire, United States|Switzerland|Czech Republic|New Zealand, United States, France, China, Europe, Southern Alberta, Canada, Poland, Michigan, USA, Midwestern US, California, Vermont|United States, Iran, Switzerland|chicken, Houston, TX, Antarctic|Mediterranean, France|New Caledonia|La Réunion Island|French Guiana|French Polynesia|Guadeloupe|Madagascar|Tunisia|India, Northwestern Sicily, Sicily, Spain, Canada, Brazil, Barcelona, Spain, Norway, Czech Republic, Mexico, Southern Malaysia, USA, Asia|Europe, Alicante city, Israel, Various zoo locations, Europe|Belgium|France|Germany|Netherlands|United Kingdom, mariculture areas | 2011, 2012, 2014, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | JM426721|JM426722|JM426723|JM426724|JM426725|JM426726|JM426727|JM426728|JM426729|JM426730|JM426731|JM426732|JM426733|JM426734|JM426735|JM426736|JM426737|JM426738|JM426739|JM426740|JM426741|JM426742|JM426743|JM426744 | - |
| tet (W) | Reslit | 1 | tetracycline | Escherichia coli | Europe | 2019 | PRJEB22062 | - |
| TETW | Reslit | 2 | tetracycline | Bacteroidetes +4 | Alberta, Canada | 2019, 2024 | - | - |
| tetW-01 | Reslit | 1 | tetracycline | - | Australia | 2020 | SRP201741 | - |
| tet W-01 | Reslit | 1 | tetracycline | - | - | 2023 | SRP443205 | - |
Occurrence of the new tetracycline resistance gene tet(W) in bacteria from the human gut.
The study identifies the tetracycline resistance gene tet(W) in human gut bacteria, showing its presence in Fusobacterium prausnitzii and Bifidobacterium longum isolates, with high sequence similarity to rumen isolates.
Occurrence of the new tetracycline resistance gene tet(W) in bacteria from the human gut.
Occurrence of the new tetracycline resistance gene tet(W) in bacteria from the human gut.
Molecular ecology of tetracycline resistance: development and validation of primers for detection of tetracycline resistance genes encoding ribosomal protection proteins.
The study identified and characterized multiple tetracycline resistance genes encoding ribosomal protection proteins (RPPs) including tet(M), tet(O), tet(W), tet(Q), tet(S), tet(T), tetB(P), and otrA. These genes were detected in various bacterial species and environments, highlighting their prevalence and potential for horizontal gene transfer.
Evidence for recent intergeneric transfer of a new tetracycline resistance gene, tet(W), isolated from Butyrivibrio fibrisolvens, and the occurrence of tet(O) in ruminal bacteria.
Widespread distribution of a tet W determinant among tetracycline-resistant isolates of the animal pathogen Arcanobacterium pyogenes.
The study identifies the tet(W) gene as a widespread determinant of tetracycline resistance in Arcanobacterium pyogenes, which is responsible for conferring resistance to tetracycline, chlortetracycline, and oxytetracycline.
Isolation of Tetracycline-Resistant Megasphaera elsdenii Strains with Novel Mosaic Gene Combinations of tet(O) and tet(W) from Swine
The study identifies novel mosaic gene combinations of tet(O) and tet(W) in tetracycline-resistant Megasphaera elsdenii strains from swine, demonstrating that these genes confer tetracycline resistance when cloned into E. coli.
Diverse tetracycline resistance genotypes of Megasphaera elsdenii strains selectively cultured from swine feces.
The study identifies multiple tetracycline resistance genotypes in Megasphaera elsdenii strains, including novel mosaic genes such as tet(OWO)-1 and tet(OWO)-2, which confer high levels of tetracycline resistance.
Diverse tetracycline resistance genotypes of Megasphaera elsdenii strains selectively cultured from swine feces.
Diverse tetracycline resistance genotypes of Megasphaera elsdenii strains selectively cultured from swine feces.
Development and Application of Real-Time PCR Assays for Quantification of Genes Encoding Tetracycline Resistance
The study developed and validated real-time PCR assays to quantify ten major classes of tetracycline resistance genes (tet) in microbiome samples, revealing significant differences in tet gene abundance between bovine and swine manures, with swine manures showing higher levels. Composting significantly reduced tet gene abundance.
Comparative analysis of sequences flanking tet(W) resistance genes in multiple species of gut bacteria.
The study identifies the tet(W) gene as a prevalent tetracycline resistance gene in gut bacteria, highlighting its conservation and mobility through various genetic elements.
Comparative analysis of sequences flanking tet(W) resistance genes in multiple species of gut bacteria.
Molecular analysis of tet(W) gene-mediated tetracycline resistance in dominant intestinal Bifidobacterium species from healthy humans.
The study identified the tet(W) gene as the cause of tetracycline resistance in Bifidobacterium species from healthy humans, demonstrating that the gene confers resistance when cloned in E. coli.
Molecular analysis of tet(W) gene-mediated tetracycline resistance in dominant intestinal Bifidobacterium species from healthy humans.
Molecular analysis of tet(W) gene-mediated tetracycline resistance in dominant intestinal Bifidobacterium species from healthy humans.
Molecular analysis of tet(W) gene-mediated tetracycline resistance in dominant intestinal Bifidobacterium species from healthy humans., Widespread distribution of a tet W determinant among tetracycline-resistant isolates of the animal pathogen Arcanobacterium pyogenes., Evidence for recent intergeneric transfer of a new tetracycline resistance gene, tet(W), isolated from Butyrivibrio fibrisolvens, and the occurrence of tet(O) in ruminal bacteria., Different genetic elements carrying the tet(W) gene in two human clinical isolates of Streptococcus suis.
Multiple genetic elements carry the tetracycline resistance gene tet(W) in the animal pathogen Arcanobacterium pyogenes.
The study identifies three genetic elements (ATE-1, ATE-2, and ATE-3) carrying the tetracycline resistance gene tet(W) in Arcanobacterium pyogenes, with ATE-1 showing characteristics of a mobilizable transposon and ATE-2 and ATE-3 being simple transposons.
Multiple genetic elements carry the tetracycline resistance gene tet(W) in the animal pathogen Arcanobacterium pyogenes.
Antibiotic susceptibility of Bifidobacterium thermophilum and Bifidobacterium pseudolongum isolates from animal sources.
The study identified the presence of tetracycline resistance genes tet(O) and tet(W), as well as the erythromycin resistance gene erm(X), in Bifidobacterium thermophilum and Bifidobacterium pseudolongum isolates from animal sources.
Determination of the genetic support for tet(W) in oral bacteria.
Monitoring and Source Tracking of Tetracycline Resistance Genes in Lagoons and Groundwater Adjacent to Swine Production Facilities over a 3-Year Period
The study identified and characterized seven tetracycline resistance genes (tet(M), tet(O), tet(Q), tet(W), tet(C), tet(H), and tet(Z)) in lagoons and groundwater near swine production facilities over a 3-year period. These genes were consistently detected in groundwater and lagoon samples, with varying frequencies and concentrations depending on the location and sampling time.
Tetracycline resistance gene tet(W) in the pathogenic bacterium Clostridium difficile.
Phenotypic and molecular assessment of antimicrobial resistance in Lactobacillus paracasei strains of food origin.
Three L. paracasei strains from cheese showed acquired resistance to tetracycline and/or erythromycin, linked to the presence of tet(M), tet(W), and erm(B) genes.
Analysis of tetracycline resistance tet(W) genes and their flanking sequences in intestinal Bifidobacterium species.
Analysis of tetracycline resistance tet(W) genes and their flanking sequences in intestinal Bifidobacterium species.
Analysis of tetracycline resistance tet(W) genes and their flanking sequences in intestinal Bifidobacterium species.
Analysis of tetracycline resistance tet(W) genes and their flanking sequences in intestinal Bifidobacterium species.
Removal of antibiotic resistance gene-carrying plasmids from Lactobacillus reuteri ATCC 55730 and characterization of the resulting daughter strain, L. reuteri DSM 17938.
The study identified and characterized the tetracycline resistance gene tet(W) and the lincomycin resistance gene lnu(A) carried on plasmids pLR581 and pLR585 in Lactobacillus reuteri ATCC 55730. These plasmids were successfully removed, resulting in the strain L. reuteri DSM 17938, which lost the corresponding resistances.
Removal of antibiotic resistance gene-carrying plasmids from Lactobacillus reuteri ATCC 55730 and characterization of the resulting daughter strain, L. reuteri DSM 17938.
Tetracycline Resistome of the Organic Pig Gut
The study identified known tetracycline resistance genes (tet(C), tet(W), tet(40)) and novel genes (galE1 and galE2) that confer resistance to tetracycline derivatives minocycline and doxycycline in the organic pig gut microbiome.
Antibiotic resistance genes in the vaginal microbiota of primates not normally exposed to antibiotics.
The study identified tetracycline resistance genes (tet(M), tet(W), tet(Q)) and erythromycin resistance genes (ermB, ermF) in the vaginal microbiota of primates not typically exposed to antibiotics, indicating the presence of antibiotic resistance genes in these animals despite limited antibiotic exposure.
Antibiotic resistance characteristics of environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river.
The study identified multiple tetracycline resistance genes (tet(A), tet(W), tet(C), tet(J), tet(L), tet(D), tet(Y), and tet(K)) in environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river, highlighting the widespread dissemination of these genes in aquatic environments exposed to high levels of antibiotic residues.
Different genetic elements carrying the tet(W) gene in two human clinical isolates of Streptococcus suis.
The study identifies the tet(W) gene in two human clinical isolates of Streptococcus suis, highlighting distinct genetic elements carrying this tetracycline resistance determinant.
Screening for antimicrobial resistance genes and virulence factors via genome sequencing.
The study identified tetracycline resistance genes tet(W) in Bifidobacterium animalis subsp. lactis strains and tet(S) in Lactococcus lactis CHCC6005 through genome sequencing and experimental validation.
Antibiotic resistance determinants in the interplay between food and gut microbiota.
The study identifies tetracycline resistance genes tet(M) and tet(W), and erythromycin resistance gene erm(B) in Lactobacillus paracasei strains isolated from Italian dairy and meat products.
The gut as reservoir of antibiotic resistance: microbial diversity of tetracycline resistance in mother and infant.
The study identified various tetracycline resistance genes, including tet(M), tet(L), erm(T), tet(W), tet(O), and tet(X), in the gut microbiota of a mother and her infant. It also discovered a novel composite transposon, Tn 6079, carrying tet(M), tet(L), and erm(T) in the infant's gut, highlighting the potential for horizontal gene transfer and maternal transmission of antibiotic resistance.
Persistence of antibiotic resistance: evaluation of a probiotic approach using antibiotic-sensitive Megasphaera elsdenii strains to prevent colonization of swine by antibiotic-resistant strains.
The study identified tetracycline resistance genes tet(O) and tet(W) in Megasphaera elsdenii strains, which were experimentally validated to confer tetracycline resistance.
Antibiotic resistance in primary and persistent endodontic infections.
The study identified bla TEM-1, cfx A, tet M, tet W, and tet Q as the most prevalent antibiotic resistance genes in endodontic infections. bla TEM-1 was more prevalent in primary infections, while tet M remained unchanged after treatment. Vancomycin resistance genes were not detected.
Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.
The study identifies multiple AMR genes and mutations in the multidrug-resistant S. suis R61 strain, including pbp2x, pbp2b, gyrA, parC, tet(W), and mef(E), contributing to resistance against β-lactams, quinolones, tetracyclines, and macrolides.
Functional metagenomics reveals previously unrecognized diversity of antibiotic resistance genes in gulls.
The study identified numerous antibiotic resistance (AR) genes in gulls, including both known and previously undescribed ones. It highlights the significant diversity of AR genes in gulls, emphasizing their potential role in spreading resistance genes between human and environmental habitats.
Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient.
The study identifies the tet(W) gene on plasmid pJA144188 as a novel tetracycline resistance determinant in Corynebacterium resistens DSM 45100, which confers resistance to tetracycline, doxycycline, and minocycline when expressed in Corynebacterium glutamicum.
Long-term exposure to antibiotics has caused accumulation of resistance determinants in the gut microbiota of honeybees.
The study identifies eight tetracycline resistance genes (tetB, tetC, tetD, tetH, tetL, tetY, tetM, and tetW) in the gut microbiota of honeybees, highlighting the accumulation of resistance determinants due to long-term antibiotic exposure in beekeeping practices.
Tetracycline resistance genes acquired at birth
The study identified tetracycline resistance genes (tet(M), tet(O), tet(Q), and tet(W)) in the microbiota of newborns and their mothers, highlighting differences in gene prevalence based on delivery mode.
Diverse antibiotic resistance genes in dairy cow manure.
The study identified 80 unique antibiotic resistance genes in dairy cow manure, including a novel clade of chloramphenicol acetyltransferases and several beta-lactamases, tetracycline resistance genes, and aminoglycoside-modifying enzymes.
Sampling and Pooling Methods for Capturing Herd Level Antibiotic Resistance in Swine Feces using qPCR and CFU Approaches.
The study identified several antibiotic resistance genes in swine fecal samples using qPCR, including tetracycline resistance genes (tet(A), tet(B), tet(C), tet(M), tet(O), tet(W)), erythromycin resistance genes (ermB, ermF), sulfonamide resistance genes (sulI, sulII), beta-lactam resistance genes (blaCTX-M-1 group, blaCMY-2, blaSHV family), and glycopeptide resistance gene (vanA).
Periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased Dominican adults.
The study identified tetracycline resistance genes tet(Q), tet(32), and tet(W) in subgingival biofilms of Dominican adults with periodontal diseases. These genes were more prevalent in chronic periodontitis patients compared to healthy individuals.
Housefly Larva Vermicomposting Efficiently Attenuates Antibiotic Resistance Genes in Swine Manure, with Concomitant Bacterial Population Changes.
The study found that housefly larva vermicomposting significantly reduces the abundance of tetracycline resistance genes (tet(M), tet(O), tet(Q), tet(W)) and increases the abundance of sulfonamide resistance genes (sul1, sul2) in swine manure. It also observed changes in the bacterial community structure, with a significant decrease in the diversity and richness of bacteria.
Survival of Antibiotic Resistant Bacteria and Horizontal Gene Transfer Control Antibiotic Resistance Gene Content in Anaerobic Digesters.
The study identified tet(G) in Pseudomonas sp. and tet(W) in Bacillus sp. as tetracycline resistance genes, highlighting their persistence in anaerobic digesters and the impact of raw sludge on antibiotic resistance gene content.
Comparative genomics of Clostridium bolteae and Clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants.
The study identified numerous antibiotic resistance genes in Clostridium bolteae and Clostridium clostridioforme, including beta-lactamases, glycopeptide resistance operons, macrolide and lincosamide resistance genes, and efflux pumps. Notably, C. bolteae 90B3 exhibited resistance to linezolid, chloramphenicol, florfenicol, and tiamulin due to the presence of the 23S rRNA methyltransferase gene cfr. Additionally, C. clostridioforme 90A8 possessed a VanB-type operon conferring vancomycin resistance.
Characterization and antimicrobial susceptibility of one antibiotic-sensitive and one multidrug-resistant Corynebacterium kroppenstedtii strain isolated from patients with granulomatous mastitis.
The study identified multidrug-resistant Corynebacterium kroppenstedtii strain CNM633/14 carrying resistance genes erm(X), tet(W), cmx, aphA1-IAB, strAB, and sul1, which confer resistance to various antibiotics including erythromycin, clarithromycin, azithromycin, clindamycin, tetracycline, chloramphenicol, kanamycin, streptomycin, and cotrimoxazole.
Prevalence of Antibiotic Resistance Genes among Human Gut-Derived Bifidobacteria.
The study identified the tet(W) gene as a significant contributor to tetracycline resistance in various Bifidobacterium species, highlighting its role in the resistome of these gut commensals.
Performance and microbial community variations of anaerobic digesters under increasing tetracycline concentrations.
The study found that the abundance of tetracycline resistance genes tetW and tetQ increased significantly in the reactor exposed to high tetracycline concentrations, indicating the development of tetracycline resistance in the microbial community.
Bacteria from Animals as a Pool of Antimicrobial Resistance Genes.
The paper discusses the role of bacteria from animals as a reservoir of antimicrobial resistance genes, highlighting the presence of various AMR genes such as erm(B), tet(M), cfr, and others in different bacterial species, emphasizing their contribution to the spread of resistance.
Analysis of newly detected tetracycline resistance genes and their flanking sequences in human intestinal bifidobacteria.
The study identified tet(W), tet(O), and tet(S) as tetracycline resistance genes in human intestinal bifidobacteria, highlighting their potential as reservoirs of resistance genes.
Transcriptional Response of Resistome to Composting and Its Implications for Antimicrobial Resistance Dissemination
The study identifies several tetracycline resistance genes (tetM, tetW, tetO, tetS), sulfonamide resistance genes (sulI, sulII), and others, showing their expression dynamics during composting and their association with microbial community shifts.
Association between selected antimicrobial resistance genes and antimicrobial exposure in Danish pig farms.
The study identified several antimicrobial resistance (AMR) genes, including ermB, ermF, sulI, sulII, tet(M), tet(O), and tet(W), and examined their association with antimicrobial exposure in Danish pig farms. The results showed complex relationships between antimicrobial exposure and AMR gene levels, with varying correlations depending on the specific gene and antimicrobial class.
Assessment of antibiotic susceptibility in Lactobacillus isolates from chickens.
The study identified several tetracycline, macrolide, and aminoglycoside resistance genes in Lactobacillus isolates from chickens, highlighting the presence of resistance mechanisms in these bacteria.
A historical legacy of antibiotic utilization on bacterial seed banks in sediments.
The study identifies and characterizes the tetracycline resistance gene tet(W) and the sulfonamide resistance gene sul1 in bacterial seed bank DNA from lake sediments, showing their historical accumulation patterns linked to antibiotic usage.
Genomic comparisons of Streptococcus suis serotype 9 strains recovered from diseased pigs in Spain and Canada.
The study identified multiple tetracycline, macrolide, lincosamide, and aminoglycoside resistance genes in Streptococcus suis serotype 9 strains, highlighting the widespread presence of antibiotic resistance mechanisms in these isolates.
Subtype-Specific Selection for Resistance to Fluoroquinolones but Not to Tetracyclines Is Evident in Campylobacter jejuni Isolates from Beef Cattle in Confined Feeding Operations in Southern Alberta, Canada.
The study identifies tetO as the primary tetracycline resistance gene in Campylobacter jejuni isolates from beef cattle and highlights gyrA mutations, particularly Thr86Ile, as a major cause of fluoroquinolone resistance.
Comparison of antimicrobial resistance genes in feedlots and urban wastewater.
The study identified various antimicrobial resistance genes in feedlots and urban wastewater, highlighting the prevalence of sulfonamide, tetracycline, macrolide, fluoroquinolone, and β-lactam resistance genes in different environments.
Antimicrobial Resistance in Streptococcus spp.
The paper discusses the prevalence and mechanisms of antimicrobial resistance in Streptococcus species, particularly focusing on macrolide, lincosamide, and tetracycline resistance. Key genes identified include erm(B), erm(A), lnuB, lnuD, mefA, mefE, msr, tet(B), tet(K), tet(L), tet(M), tet(O), and tet(S).
Investigating the transmissibility of tet(W) in bifidobacteria exposed to acid and bile stress.
The study investigated the transmissibility of the tetracycline resistance gene tet(W) in Bifidobacterium isolates under acid and bile stress conditions and found no evidence of gene transfer to Enterococcus faecalis ATCC 51299.
Safety Evaluations of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI.
B. bifidum BGN4 and B. longum BORI were found to be resistant to gentamicin and tetracycline, but the resistance was not transferable. The study also found that B. longum BORI contains the tet(W) gene, which is responsible for tetracycline resistance.
Dissemination of antibiotic resistance genes associated with the sporobiota in sediments impacted by wastewater.
The study identifies tet(W) and sul1 as prevalent antibiotic resistance genes in the sporobiota of sediments impacted by wastewater, showing their association with the wastewater treatment plant discharge and their spatial distribution patterns.
Transcriptional and Functional Analysis of Bifidobacterium animalis subsp. lactis Exposure to Tetracycline.
The study identified the tet(W) gene as a key contributor to tetracycline resistance in Bifidobacterium animalis subsp. lactis strains Bl-04 and HN019, with differential gene expression patterns observed between the strains.
Identification and antibiotic susceptibility of lactobacilli isolated from turkeys.
The study identified several tetracycline, macrolide, and lincosamide resistance genes in turkey-derived lactobacilli, including tetL, tetM, tetW, ermB, ermC, lnuA, aadE, ant(6)-Ia, cat, and lsaE. These genes were associated with resistance to tetracycline, erythromycin, lincomycin, streptomycin, chloramphenicol, and tiamulin.
Novel virulence, antibiotic resistance and toxin gene-specific PCR-based assays for rapid pathogenicity assessment of Arcobacter faecis and Arcobacter lanthieri.
The study identified and characterized the tet(O) and tet(W) genes in Arcobacter faecis and Arcobacter lanthieri, which confer resistance to tetracycline.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
Manure and Doxycycline Affect the Bacterial Community and Its Resistome in Lettuce Rhizosphere and Bulk Soil.
The study identified the tetracycline resistance gene tetA(P) as being highly enriched in manure-treated soil and rhizosphere, particularly in doxycycline-treated bulk soil, indicating its potential as a marker for soil contamination by antibiotic-resistant bacteria and antibiotics.
Associations between antimicrobial use and the faecal resistome on broiler farms from nine European countries.
The study identified several antimicrobial resistance genes associated with antimicrobial use on broiler farms, including bla TEM, erm (B), tet (W), aadA cluster, cmx, and dfrA1.
Effect of Single Dose of Antimicrobial Administration at Birth on Fecal Microbiota Development and Prevalence of Antimicrobial Resistance Genes in Piglets.
Early life antimicrobial interventions, specifically procaine penicillin G (PPG) and tulathromycin (TUL), significantly increased the relative abundance of ermB and tetW in piglets, suggesting a promotion of antimicrobial resistance genes in the gut microbiota.
Comparative diversity of microbiomes and Resistomes in beef feedlots, downstream environments and urban sewage influent.
The study identified several tetracycline, macrolide, aminoglycoside, beta-lactam, sulfonamide, mercury, and biocide resistance genes in beef feedlots, catch basin water, soil, and urban sewage influent. Tetracycline resistance was predominant in beef production systems, while urban sewage influent showed a diverse resistome with resistance to multiple antimicrobial classes.
Characterization of Discriminatory Antimicrobial Resistance Genes in Aquatic Environments Using Machine Learning
The study identifies discriminatory antibiotic resistance genes (ARGs) using an extremely randomized tree (ERT) algorithm, highlighting genes like sul1, tet(W), and ermB as significant markers for differentiating resistomes across various aquatic environments.
The fecal resistome of dairy cattle is associated with diet during nursing.
The study identified various antimicrobial resistance genes (ARGs) in the fecal microbiota of dairy calves, highlighting the association between diet and the resistome. Key genes include ermB, lnuC, mefA, tet32, tet40, tetO, tetQ, tetW, and optrA, which confer resistance to macrolides, lincosamides, streptogramin B, and tetracyclines, as well as oxazolidinones and phenicols.
Manure Application Did Not Enrich Antibiotic Resistance Genes in Root Endophytic Bacterial Microbiota of Cherry Radish Plants.
The study found that manure application increased the occurrence of antibiotic resistance genes (ARGs) in the rhizosphere and phyllosphere of cherry radish, but not in the endophytic bacterial microbiota of the root, which is the edible part of the plant.
Characterization of antibiotic resistance genes in the species of the rumen microbiota.
The study identifies and characterizes tetracycline resistance genes, including tet(W), tet(Q), and tet(O), in ruminal microbial genomes, highlighting the presence of a novel integrative and conjugative element (ICE_ RbtetW_07 ) associated with tetracycline resistance.
Resistome metagenomics from plate to farm: The resistome and microbial composition during food waste feeding and composting on a Vermont poultry farm.
The study identified 50 unique antibiotic resistance genes (ARGs) in food waste, compost, and farm products, with a focus on aminoglycoside, tetracycline, and macrolide resistance. Key ARGs included aph(6)-1d, lmrD, mefA, mel, abeM, abeS, adeF, adeG, adeI, adeJ, adeK, emrD, sul2, tetH, tetM, tetO, tetW, and tetX, which were found in various samples and showed resistance to multiple drug classes.
Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.
The study identified a novel macrolide-clindamycin resistance gene, erm(50), and a tetracycline resistance gene, tet(W), on a transferable multidrug-resistant plasmid pTZC1 in Cutibacterium acnes.
Antimicrobial Resistance in Clostridium and Brachyspira spp. and Other Anaerobes.
The paper describes the antimicrobial resistance mechanisms in Clostridium and Brachyspira spp. and other anaerobes, focusing on the genetic basis of resistance to various antibiotics, including tetracyclines, macrolides, lincosamides, chloramphenicol, and others. It highlights the role of specific genes such as tet, erm, and cat in conferring resistance.
Metatranscriptomics Reveals Antibiotic-Induced Resistance Gene Expression in the Murine Gut Microbiota.
The study identifies specific AMR genes, including beta-lactamase genes (cepA, bl2e_cepA) and tetracycline resistance genes (tet32, tet44, tetW), that are upregulated in response to amoxicillin and doxycycline treatments in the murine gut microbiota.
Antibiotic Susceptibility Profiles of Lactic Acid Bacteria from the Human Vagina and Genetic Basis of Acquired Resistances.
Toxin profiles and antimicrobial resistance patterns among toxigenic clinical isolates of Clostridioides (Clostridium) difficile.
The study identified ermB, tetM, and tetW genes as the primary determinants of clindamycin, tetracycline, and moxifloxacin resistance in C. difficile isolates. Mutations in GyrA (Thr82→Ile) and GyrB (Asp426→Asn) were linked to moxifloxacin resistance.
Isolation and Comparative Genomic Analysis of Reuterin-Producing Lactobacillus reuteri From the Chicken Gastrointestinal Tract.
The study identified ermB and tetW genes in L. reuteri strains from chicken GIT, which confer resistance to erythromycin and tetracycline, respectively. These genes were validated through PCR and sequencing.
Risk for the development of Antimicrobial Resistance (AMR) due to feeding of calves with milk containing residues of antibiotics.
The paper discusses the risk of antimicrobial resistance development in calves due to feeding with milk containing antibiotic residues, highlighting the role of β-lactamases in reducing β-lactam concentrations.
In vitro activity of eravacycline against common ribotypes of Clostridioides difficile.
The study found that eravacycline showed potent in vitro activity against various ribotypes of Clostridioides difficile, and the presence of tetM or tetW resistance genes did not affect the MIC of eravacycline.
Antibiotic Resistance Genes in Phage Particles from Antarctic and Mediterranean Seawater Ecosystems.
The study identified several antibiotic resistance genes (ARGs) in phage particles from Antarctic and Mediterranean seawater, highlighting the presence of beta-lactamase genes (bla TEM, bla CTX-M-1, bla CTX-M-9), tetracycline resistance gene (tetW), and sulfonamide resistance gene (sul1). These genes were detected in phage particles from both regions, indicating their potential role in the dissemination of antibiotic resistance.
A metagenomic-based method to study hospital air dust resistome.
The study identifies the presence of antibiotic resistance genes (ARGs) in hospital air dust, highlighting the role of the Outpatient hall as a major source of ARG transmission. Key genes such as intI1 and tetW were detected, showing the prevalence of multidrug and tetracycline resistance.
Pyrolyzed biowastes deactivated potentially toxic metals and eliminated antibiotic resistant genes for healthy vegetable production.
The study found that pyrolysis of biowastes effectively reduced the abundance of antibiotic resistance genes (ARGs) such as tetracycline resistance genes (tetC, tetG, tetM, tetO, tetW), sulfonamide resistance genes (sul1, sul2), and class 1 integron-integrase gene (intI1) in swine manure and sewage sludge.
Sewer biofilm microbiome and antibiotic resistance genes as function of pipe material, source of microbes, and disinfection: field and laboratory studies.
This study identified various antibiotic resistance genes (ARGs) in sewer biofilms, including sul1, blaTEM, tet(G), tet(O), tet(W), and ermF, which were detected in field and simulated sewer biofilm samples. The research also explored the effects of disinfection protocols on biofilm persistence.
The Role of Urban Wastewater in the Environmental Transmission of Antimicrobial Resistance: The Current Situation in Italy (2010-2019).
The study identified several AMR genes in urban wastewater treatment plants in Italy, including bla TEM-1, bla AmpC, bla CTX-M-15, bla KPC-3, bla SHV-1, tet A, sul II, erm B, qnr S, int I1, aad A2, dfr 17, aadA 5, aadA 10, sat 1, bla TEM, bla OXA, bla CTX, bla KPC, and tet W. These genes confer resistance to various antibiotics such as beta-lactams, tetracyclines, sulfonamides, macrolides, fluoroquinolones, and aminoglycosides.
Early Inoculation of Microbial Suspension in Suckling Piglets Affects the Transmission of Maternal Microbiota and the Associated Antibiotic Resistance Genes.
The study shows that early inoculation of microbial suspensions affects the transmission of maternal microbiota and the associated antibiotic resistance genes (ARGs) in piglets. Specific ARGs such as aadE_2, aphA3, ermB, lnuB, vanTG, tetQ, tnpA, mpmB, lnuC, and tetW were found to be influenced by the inoculation of microbial suspensions S1 and S2.
Population genomics and antimicrobial resistance in Corynebacterium diphtheriae.
The study identifies several AMR genes in Corynebacterium diphtheriae, including pbp2m associated with penicillin resistance, ermX for macrolide resistance, and various genes for tetracycline, aminoglycoside, and sulfonamide resistance.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
The distribution of antibiotic resistance genes in chicken gut microbiota commensals.
The study identified various tetracycline resistance genes including tet(W), tet(Q), tet(32), tet(O), tet(44), tetA(P), and tetB(P) in chicken gut microbiota commensals, highlighting their distribution across different bacterial families.
Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins.
The study identifies several ribosomal protection protein (RPP) genes, including tet(M), tet(O), tet(W), tet(Q), tetB(P), and otr(A), that can confer high-level tetracycline resistance in E. coli. However, expression of these genes often comes with fitness costs, and certain mutations in tRNA genes (argW and proL) or the hns gene can mitigate these costs.
Combined effects of composting and antibiotic administration on cattle manure-borne antibiotic resistance genes.
Composting reduces the relative abundance of total antibiotic resistance genes (ARGs) in manure, but certain clinically relevant ARGs like beta-lactam and sul1 remain persistent. The study highlights the impact of composting on the resistome composition and the importance of managing antibiotic use in livestock.
A Comparative Analysis of Aquatic and Polyethylene-Associated Antibiotic-Resistant Microbiota in the Mediterranean Sea.
The study found that polyethylene (PE) waste samples from both seawater and freshwater contained a higher number of antibiotic resistance genes (ARGs) compared to the corresponding water samples, highlighting the role of PE as a carrier of ARGs in the marine environment.
Occurrence and Antimicrobial Resistance of Arcobacter spp. Recovered from Aquatic Environments.
The study identified tetracycline resistance genes tetO and tetW in Arcobacter butzleri isolates, highlighting the presence of multidrug-resistant Arcobacter strains in aquatic environments.
Trueperella pyogenes Isolates from Livestock and European Bison (Bison bonasus) as a Reservoir of Tetracycline Resistance Determinants.
The study identified tetW and tetA(33) as the primary tetracycline resistance genes in Trueperella pyogenes isolates from livestock and European bison. tetW was the most prevalent, with four variants (tetW-1, tetW-2, tetW-3, tetW-4) and was linked to transposons ATE-1 and ATE-2. tetA(33) was less common but also contributed to resistance.
High-throughput sequencing reveals genetic determinants associated with antibiotic resistance in Campylobacter spp. from farm-to-fork.
The study identified several AMR genes and mutations associated with resistance to quinolones, tetracyclines, and macrolides in Campylobacter isolates from various sources. Key findings include the prevalence of blaOXA-61, tet(O), and mutations in gyrA and 23S rRNA genes.
Factors associated with elevated levels of antibiotic resistance genes in sewer sediments and wastewater.
The study identified several antibiotic resistance genes (ARGs) in sewer sediments and wastewater, including sul1, tet(O), tet(W), ermF, vanA, NDM-1, mcr-1, and mecA, highlighting the potential for ARG proliferation in sewer environments.
The Tetracycline Resistance Gene, tet(W) in Bifidobacterium animalis subsp. lactis Follows Phylogeny and Differs From tet(W) in Other Species.
The tetracycline resistance gene tet(W) in Bifidobacterium animalis subsp. lactis is part of the ancient resistome and exhibits a conserved genomic context, distinguishing it from tet(W) in other species.
Honeybee Exposure to Veterinary Drugs: How Is the Gut Microbiota Affected?
The study identified tetracycline resistance genes tetW and tetY, and sulfonamide resistance genes sul1 and sul2 in the honeybee gut microbiota, which increased in abundance following antibiotic treatment.
Climatological and Epidemiological Conditions Are Important Factors Related to the Abundance of bla(KPC) and Other Antibiotic Resistance Genes (ARGs) in Wastewater Treatment Plants and Their Effluents, in an Endemic Country.
The study identified the prevalence of antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs) in Colombia, highlighting the significant presence of bla KPC, sul 1, sul 2, erm B, and others. It also found that environmental factors such as dissolved oxygen and precipitation correlate with the abundance of these genes.
Genomic and pathogenic investigations of Streptococcus suis serotype 7 population derived from a human patient and pigs.
The study identified several AMR genes in Streptococcus suis serotype 7 strains, including tetracycline resistance genes (tet(O), tet(M), tet(W)), macrolide/lincosamide/streptogramin resistance gene (erm(B)), aminoglycoside resistance genes (ant(6)-Ia, aph(3')-IIIa, aac(6')-Ie-aph(2'')-Ia), trimethoprim resistance gene (dfrF), and chloramphenicol resistance gene (cat-TC).
Danofloxacin Treatment Alters the Diversity and Resistome Profile of Gut Microbiota in Calves.
Danofloxacin treatment altered the gut microbiota diversity and resistome profile in calves, increasing the frequency and host range of several antimicrobial resistance genes (ARGs) such as aac(6')-Ib, ant9, tet40, tetW, ermF, tetL, and tetX.
Resistome Analysis in the Digestive Tract of Food-Producing Animals
The study identifies tetW and mefA as highly expressed tetracycline and macrolide resistance genes in the rumen of beef cattle, highlighting their significance in the resistome of food-producing animals.
Impact of Antibiotic Therapies on Resistance Genes Dynamic and Composition of the Animal Gut Microbiota.
The study examined the impact of antibiotic therapies on the dynamics and composition of resistance genes in the animal gut microbiota, identifying several AMR genes such as blaTEM, tetA, strA, strB, intI1, tetM, mel, floR, mcr-2, oqx B, tetC, tetG, tetO, tetW, tetX, ermB, ermF, sul1, sul2, and others, which were experimentally validated in Escherichia coli.
New Sequence Types and Antimicrobial Drug-Resistant Strains of Streptococcus suis in Diseased Pigs, Italy, 2017-2019.
The study identified several AMR genes in Streptococcus suis isolates from diseased pigs in Italy, including ermb, tet(O), aac6-aph2, ant6-ia, aph3-iiia, spw, tet(40), tet(W), tet(O/W/32/O), tet(W/N/N), erm(47), lnuB, lsaE, and optrA, which confer resistance to various antibiotics such as erythromycin, tetracycline, gentamicin, lincomycin, and linezolid.
Quantification of antibiotic resistance genes and mobile genetic in dairy manure.
The study identified and quantified several antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in dairy manure samples, highlighting the prevalence of sulII, tetW, ermF, tnpA, and intI1 across different manure management conditions.
Classification of 27 Corynebacterium kroppenstedtii-Like Isolates Associated with Mastitis in China and Descriptions of C. parakroppenstedtii sp. nov. and C. pseudokroppenstedtii sp. nov.
The study identifies two new species, Corynebacterium parakroppenstedtii and Corynebacterium pseudokroppenstedtii, and characterizes antibiotic resistance genes including APH(3')-Ia, APH(3'')-Ib, APH(6)-Id, erm(X), sul1, and tet(W) in C. kroppenstedtii-like isolates.
Chicken liver is a potential reservoir of bacteriophages and phage-derived particles containing antibiotic resistance genes.
The study identified various antibiotic resistance genes (ARGs) in phage DNA fractions of chicken liver samples, including blaTEM, blaCTX-M-1, sul1, qnrA, armA, and tetW, indicating the potential of chicken liver as a reservoir for phage-mediated antibiotic resistance.
Evaluating the potential of third generation metagenomic sequencing for the detection of BRD pathogens and genetic determinants of antimicrobial resistance in chronically ill feedlot cattle.
The study identified various antimicrobial resistance genes (ARGs) in metagenomic sequencing data from chronically ill feedlot cattle, including genes conferring resistance to beta-lactams, aminoglycosides, macrolides, phenicols, tetracyclines, and trimethoprim. Notably, tetH was the most frequently detected resistance gene, and several ARGs were found to be associated with integrative and conjugative elements (ICEs).
Comparative genomics analysis and virulence-related factors in novel Aliarcobacter faecis and Aliarcobacter lanthieri species identified as potential opportunistic pathogens.
The study identified tetracycline resistance genes tet(O) and tet(W) in Aliarcobacter faecis and Aliarcobacter lanthieri through PCR assays, indicating the prevalence of tetracycline resistance within the genus Aliarcobacter.
Genomic diversity of genus Limosilactobacillus.
The study identified 18 AMR genes in Limosilactobacillus species, primarily in L. reuteri from animal sources, including tetracycline, aminoglycoside, macrolide-lincosamide-streptogramin, and lincomycin resistance genes.
The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs.
The study identified ermG as a gene that increased in abundance in the feces of treated pigs compared to those that did not receive post-PRRS antimicrobials, indicating its role in macrolide, lincosamide, and streptogramin B resistance.
Exploring the Bacteriome and Resistome of Humans and Food-Producing Animals in Brazil.
The study identified various antimicrobial resistance genes (ARGs) in humans and food-producing animals in Brazil, including novel carbapenemase-encoding genes such as blaAIM-1, blaCAM-1, blaGIM-2, and blaHMB-1, which were not previously reported in Latin America. Other significant ARGs included aac(6')-Ib-cr, ermF, ermB, ermG, tetO, tetQ, tetW, qnrB10, qnrB19, qnrD1, and crpP.
Antibiotic Resistance in Bacteria-A Review.
The review discusses various mechanisms of antibiotic resistance in bacteria, including resistance genes such as blaCTX-M, ermB, tet(O), vanA, vanB, and aac(6')-Ie-aph(2")-Ia, as well as mutations in gyrA, gyrB, and 23S rRNA associated with resistance to fluoroquinolones, macrolides, and other antibiotics.
Antibiotic-Resistant Bacteria and Resistance Genes in Isolates from Ghanaian Drinking Water Sources.
The study identified antibiotic-resistant bacteria carrying resistance genes such as bla_NDM-1, sul1, tet(O), and tet(W) in Ghanaian drinking water sources, highlighting the presence of multidrug-resistant isolates and the potential public health risks associated with contaminated water.
Dominance of phage particles carrying antibiotic resistance genes in the viromes of retail food sources.
The study identifies and characterizes the presence of antibiotic resistance genes (ARGs) in phage particles from retail food sources, demonstrating that these phages can carry and potentially transfer resistance genes such as bla TEM, sul1, and tetW.
Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 Streptococcus suis isolates from healthy pigs.
The study identified 18 AMR genes in non-serotype 2 Streptococcus suis isolates from healthy pigs, including genes conferring resistance to aminoglycosides, macrolides, lincosamides, tetracyclines, oxazolidinones, nucleosides, and phenicols.
Serious Risk of Tigecycline Resistance in Escherichia coli Isolated from Swine Manure.
The study identifies the presence of various tetracycline resistance genes (TRGs) in doxycycline-resistant E. coli (DRE) strains isolated from swine manure, highlighting the significant risk of tigecycline resistance. The tetX and tet(X4) genes were found to be strongly associated with tigecycline resistance.
Characterization of antibiotic-resistance traits in Akkermansia muciniphila strains of human origin.
The study identified several AMR genes in Akkermansia muciniphila strains, including adeF, tetW, sul2, and aph(6)-Id. Only the strain Amap1 showed resistance to tetracycline due to the presence of tetW. The presence of ARGs does not always translate into a resistant phenotype.
The pan-genome of the emerging multidrug-resistant pathogen Corynebacterium striatum.
The study identifies 15 antimicrobial resistance genes in Corynebacterium striatum, including genes conferring resistance to aminoglycosides, tetracyclines, chloramphenicol, macrolides, lincosamides, streptogramins, sulfonamides, and cationic antiseptics. These genes are often located in genomic islands and mobile genetic elements, highlighting the role of horizontal gene transfer in the spread of multidrug resistance.
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
The study found that prolonged amoxicillin treatment leads to an increase in the abundance and diversity of antimicrobial resistance genes (ARGs) in the gut microbiome, particularly beta-lactamase genes such as cfxA and its variants, as well as tetracycline and macrolide resistance genes.
Microbiological Biodiversity of Regional Cow, Goat and Ewe Milk Cheeses Produced in Poland and Antibiotic Resistance of Lactic Acid Bacteria Isolated from Them.
The study identified tetracycline, erythromycin, and chloramphenicol resistance genes in lactic acid bacteria isolated from regional cheeses in Poland.
Antibiotic Susceptibility, Resistance Gene Determinants and Corresponding Genomic Regions in Lactobacillus amylovorus Isolates Derived from Wild Boars and Domestic Pigs.
The study identified tetracycline resistance gene tetW, erythromycin resistance gene ermB, and streptomycin resistance gene aadE in Lactobacillus amylovorus isolates from domestic pigs, while only one wild boar isolate carried aadE. The findings highlight differences in resistance gene prevalence between wild and domestic pigs.
Antimicrobial Resistance of Seventy Lactic Acid Bacteria Isolated from Commercial Probiotics in Korea.
Two AMR genes were detected: lnu(A) in a clindamycin-susceptible and lincomycin-resistant Limosilactobacillus reuteri isolate, and tet(W) in multiple Bifidobacterium isolates.
Root canal microbiota as an augmented reservoir of antimicrobial resistance genes in type 2 diabetes mellitus patients.
The study identifies that root canal microbiota in T2DM patients harbor a higher prevalence of antimicrobial resistance genes (ARGs) compared to non-diabetic patients, particularly for tetW, tetM, ermB, ermC, cfxA, and tetQ.
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteria.
The study identified several acquired and intrinsic antimicrobial resistance genes in lactic acid bacteria and bifidobacteria, including tetW, ANT(6)-Ia, aac(6')-Ie-APH(2'')-Ia, erm(B), erm(49), cat, dfrG, arr-4, and fosXCC. Additionally, mutations in S12, rsmG, Lsa(A), MsrC, and PBP5 were associated with resistance to various antibiotics.
Effects of levodopa on gut bacterial antibiotic resistance in Parkinson's disease rat.
Levodopa treatment influenced the abundance of antibiotic resistance genes in gut bacteria of Parkinson's disease rats, decreasing tetW and vanTG while increasing AAC6-Ib-Suzhou.
Metagenomic analysis reveals patterns and hosts of antibiotic resistance in different pig farms.
The study identified various antibiotic resistance genes (ARGs) in pig manure samples from different regions of Shanxi, China, highlighting the prevalence of tetracycline, aminoglycoside, macrolide, and phenicol resistance genes. Key ARGs included tet(W), tet(40), tet(Q), erm(B), erm(F), mef(A), aph(3')-III, ant(6)-Ia, cfr(C), floR, blaACI-1, optrA, cat, cfxA4, cfxA5, blaCTX-M-105, blaCTX-M-65, fexB, erm(T), mdf(A), and ole(B).
Correlations among Antibiotic Resistance Genes, Mobile Genetic Elements and Microbial Communities in Municipal Sewage Treatment Plants Revealed by High-Throughput Sequencing.
The study identifies various tetracycline resistance genes (tetC, tetE, tetG, tetM, tetO, tetQ, tetW, tetX), sulfonamide resistance gene (sulI), aminoglycoside resistance genes (ant(2')-Ia, ant(3')-Ia, aph(6')-Id, aph(33')-Ib, aac(6')-Ib), beta-lactam resistance genes (blaGES, blaVEB), chloramphenicol resistance gene (catB3), MLS resistance genes (ereA, ermB), and multidrug resistance genes (acrB, mexB, mexF) in municipal sewage treatment plants, highlighting their association with mobile genetic elements and microbial communities.
Multidrug Resistance Plasmid pTZC1 Could Be Pooled among Cutibacterium Strains on the Skin Surface.
The study identifies the multidrug resistance plasmid pTZC1, which contains the macrolide-clindamycin resistance gene erm(50) and the tetracycline resistance gene tet(W), and demonstrates its transfer between Cutibacterium acnes and Cutibacterium granulosum strains.
Antibiotic resistance and resistance mechanism of Corynebacterium kroppenstedtii isolated from patients with mastadenitis.
The study identified erm(X), sul(1), and tet(W) genes in Corynebacterium kroppenstedtii isolates, which confer resistance to erythromycin, clindamycin, trimethoprim-sulfamethoxazole, and tetracycline. Additionally, mutations in the gyrA gene were linked to ciprofloxacin resistance.
Potential of Bifidobacterium lactis IDCC 4301 isolated from breast milk-fed infant feces as a probiotic and functional ingredient.
Bifidobacterium lactis IDCC 4301 was found to possess the tetracycline resistance gene tetW, but it was susceptible to all other antibiotics tested, except vancomycin.
Food risk associated with vegetable consumption, exposure to antimicrobial-resistant strains and pesticide residues.
The study identified several antimicrobial resistance genes in AMR strains isolated from vegetables, including blaTEM, tetA, tetW, tetC, tetD, tetB, qnrS, and sulI. These genes conferred resistance to various antibiotics such as ampicillin, amoxicillin/clavulanic acid, tetracycline, ciprofloxacin, nalidixic acid, and trimethoprim/sulfamethoxazole.
An Insight into the Exploration of Antibiotic Resistance Genes in Calorie Restricted Diet Fed Mice.
The study found that calorie restriction increased the abundance of tetracycline resistance genes (tet W-01) and decreased the abundance of MLSB resistance genes (erm B) in mouse feces. It also identified that sul 2 was associated with sulfonamide resistance.
Antibiotic Susceptibility Testing and Establishment of Tentative Species-Specific Microbiological Cut-off Values for Bifidobacteria Isolated from Chinese Population.
The study identifies tetracycline resistance gene tet(W), erythromycin/clindamycin resistance gene ermX, and rifampicin resistance gene rpoB in Bifidobacterium species, highlighting species-specific antibiotic resistance profiles.
Social demographics determinants for resistome and microbiome variation of a multiethnic community in Southern Malaysia.
The study identified 1038 antibiotic resistance genes from 200 community participants, highlighting the association of resistome profiles with lifestyle and environmental factors, particularly emphasizing the role of Escherichia coli in the resistome dynamics.
Development of a portable on-site applicable metagenomic data generation workflow for enhanced pathogen and antimicrobial resistance surveillance.
The study characterizes several antimicrobial resistance genes, including tet(W), tet(Q), mdf(A), erm(B), lsa(A), and aac(6')-Iaa, through the use of a spiked-in mock community and long-read sequencing.
Altered microbiota, antimicrobial resistance genes, and functional enzyme profiles in the rumen of yak calves fed with milk replacer.
The study identified 138 antimicrobial resistance genes (ARGs) in the rumen of yak calves, with tetracycline resistance being the most prevalent. The study also found that feeding milk replacer (MR) altered the rumen resistome and microbiota, increasing the abundance of Prevotella and affecting the functional enzyme profiles.
Complete genome sequencing and comparative genomic analysis of three donkey Streptococcus equi subsp. equi isolates.
The study identified multiple antibiotic resistance genes in three donkey-derived Streptococcus equi subsp. equi isolates, including genes conferring resistance to beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others. Notably, the HT1112 isolate showed resistance to six antimicrobials, while HTP133 and HTP232 showed resistance to fewer drugs. Additionally, the study highlighted the role of biofilm formation in antimicrobial resistance.
The fate of antibiotic resistance genes during anaerobic digestion of sewage sludge with ultrasonic pretreatment.
The study investigated the effect of ultrasonic pretreatment on the fate of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) during anaerobic digestion of sewage sludge. It found that ultrasonic pretreatment significantly reduced the relative abundance of ARGs and MGEs, with 60 minutes of pretreatment achieving the highest removal rate of 41.70% for total ARGs.
Metagenomics reveals the temporal dynamics of the rumen resistome and microbiome in goat kids.
The study identified numerous antibiotic resistance genes (ARGs) in the rumen of goat kids, highlighting the dynamic nature of the resistome influenced by age and diet. Key ARGs included RPOB, GYRA, GYRBA, ROB, MDTF, ACRF, ACRB, MGTA, MLS23S, TUFAB, TET44, TET32, APH2-DPRIME, SAT, BRO, TETQ, ERMF, NIMJ, ACI, MEFA, RRSC, RRSH, CAP16S, TETX, LNUC, TETW, TETO, and TET40, which were associated with resistance to various antibiotics such as drugs, MLS, tetracyclines, and others.
Airway "Resistotypes" and Clinical Outcomes in Bronchiectasis.
The study identifies distinct 'resistotypes' in bronchiectasis patients, showing associations with clinical outcomes, geographic origin, and the underlying microbiome. Targeted eradication of P. aeruginosa leads to a shift from a less favorable resistotype to a more favorable one.
Identification of knowledge gaps in whole-genome sequence analysis of multi-resistant thermotolerant Campylobacter spp.
The study identified 22 different resistance genes and gene variants, including erm(B), aph(3')-IIIa, aadE, catA, lnu(C), blaOXA, sat4, tet(O), and point mutations in gyrA, 23S rRNA, and rpsL, associated with antimicrobial resistance in thermotolerant Campylobacter spp.
City-scale monitoring of antibiotic resistance genes by digital PCR and metagenomics.
The study monitored the abundance and distribution of sul2 and tetW genes, which confer resistance to sulfonamide and tetracycline, respectively, in various water samples using digital PCR and metagenomics.
The effects of antibiotic exposures on the gut resistome during hematopoietic cell transplantation in children.
The study identified 372 unique antibiotic resistance genes (ARGs) in the gut microbiome of children undergoing hematopoietic cell transplantation, with tetracycline, beta-lactam, and fluoroquinolone resistance genes being the most prevalent. Anaerobic antibiotic exposures were associated with an increase in the acquisition of new ARGs and the relative abundance of ARGs in the gut resistome.
Heterogeneous Antibiotic Resistance Gene Removal Impedes Evaluation of Constructed Wetlands for Effective Greywater Treatment.
The study identifies several antibiotic resistance genes (ARGs) in greywater and filter bed samples, including blaTEM, sul1, intI1, tetG, tetW, and others, indicating the presence of resistance to beta-lactams, sulfonamides, tetracyclines, and other antibiotics. The research highlights the variability in ARG removal efficiency by constructed wetlands and the potential for ARG proliferation in treated greywater.
Antimicrobial susceptibility and resistome of Actinobacillus pleuropneumoniae in Taiwan: a next-generation sequencing analysis.
The study identified multiple antimicrobial resistance genes in Actinobacillus pleuropneumoniae isolates from Taiwan, including aminoglycoside, tetracycline, beta-lactam, macrolide, and phenicol resistance genes, highlighting the prevalence of multidrug resistance.
Molecular Characterization of Resistance and Virulence Factors of Trueperella pyogenes Isolated from Clinical Bovine Mastitis Cases in China.
The study identified aadA9, tetW, ermX, aadA1, aadA11, strA-strB, and aadB as key AMR genes in T. pyogenes isolates from bovine mastitis in China, highlighting high resistance to streptomycin and tetracycline.
Metagenomic Investigation of the Short-Term Temporal and Spatial Dynamics of the Bacterial Microbiome and the Resistome Downstream of a Wastewater Treatment Plant in the Iskar River in Bulgaria.
The study identified various antimicrobial resistance genes (ARGs) in the Iskar River downstream of a wastewater treatment plant (WWTP), including genes conferring resistance to macrolides, tetracyclines, beta-lactams, sulfonamides, and carbapenems. Notably, the carbapenemase genes bla OXA-58 and bla IMP-33-like were detected, which are typically associated with clinical settings.
Deeper Exploration of Gut Microbiome: Profile of Resistome, Virome and Viral Auxiliary Metabolic Genes of Three Ethnic Indian Groups.
The study identified tetracycline resistance genes tet(W), erm(F), and tet(Q) in the gut microbiomes of three Indian ethnic groups, with higher burdens observed in the Khargone and Ladakh groups compared to the Jaisalmer group.
Infection by a multidrug-resistant Corynebacterium diphtheriae strain: prediction of virulence factors, CRISPR-Cas system analysis, and structural implications of mutations conferring rifampin resistance.
Computational Analysis of Antibiotic Resistance Genes Using Pretrained Language Models
The study introduces a novel method for predicting antibiotic resistance mechanisms using ProteinBERT, a protein language model. The model outperforms existing methods on diverse ARG datasets, particularly those with low homology to known sequences. Attention analysis reveals that the model considers biologically relevant features such as conserved amino acid residues and antibiotic target binding sites.
Faecal microbiota and cytokine profiles of rural Cambodian infants linked to diet and diarrhoeal episodes.
The study identified antimicrobial resistance genes such as erm(X), tet(O), tet(O/23/O), tet(Q), and tet(W) in Bifidobacterium isolates from Cambodian infants, highlighting the presence of resistance mechanisms in the gut microbiota.
Exploring microbial diversity and biosynthetic potential in zoo and wildlife animal microbiomes.
The study identified various AMR genes in zoo animal microbiomes, including resistance to tetracyclines, lincomamides, fluoroquinolones, vancomycin, beta-lactams, and aminoglycosides.
Molecular characterization of Streptococcus suis isolates recovered from diseased pigs in Europe.
The study identified high frequencies of tetracycline and macrolide resistance genes, specifically tetO and ermB, in European Streptococcus suis isolates.
Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome.
The study found that doxy-PEP use over 6 months significantly increased the proportion and expression of tetracycline resistance genes in the gut microbiome, with no significant changes in other antibiotic resistance gene classes.
Contribution of the Mobilome to the Configuration of the Resistome of Corynebacterium striatum.
The study identified 20 antimicrobial resistance genes in Corynebacterium striatum, with ErmX being the most prevalent. These genes are mainly associated with plasmid sequence regions and class 1 integrons, highlighting the role of mobile genetic elements in the dissemination of resistance.
Prevalence, Virulence Genes, Drug Resistance and Genetic Evolution of Trueperella pyogenes in Small Ruminants in Western China.
The study identified eight resistance genes in Trueperella pyogenes isolates from small ruminants in western China, including ant(2")-Ia, ant(3")-Ia, cmlA1, cmx, erm(X), lnu(A), sul1, and tet(W). These genes conferred resistance to various antibiotics such as gentamicin, chloramphenicol, erythromycin, clindamycin, sulfisoxazole, and tetracycline.
The tetracycline resistome is shaped by selection for specific resistance mechanisms by each antibiotic generation.
The study identifies specific tetracycline resistance mechanisms (efflux pumps, ribosomal protection proteins, and type 1 tetracycline destructases) that are preferentially selected by different generations of tetracycline antibiotics, highlighting the evolutionary dynamics of resistance.
Prevalence and genetic characteristics of Campylobacter jejuni from laying-hens in Hubei Province, China.
The study identified multiple antibiotic resistance genes in Campylobacter jejuni isolates from laying-hens in Hubei Province, China, including blaOXA, tet(O), tet(M), tet(W), cmeR, and gyrA (T86I). High resistance rates were observed against ceftriaxone, enrofloxacin, doxycycline, and other antibiotics.
Isolation, Identification, and Molecular Genetic Characteristics of a Pathogenic Strain of Streptococcus suis Serotype 3.
The study identified the presence of the tet(W) and erm(B) genes in the S. suis strain YA, which confer resistance to tetracyclines and macrolide-lincosamide-streptogramin antibiotics, respectively.
Microplastics enhance the prevalence of antibiotic resistance genes in mariculture sediments by enriching host bacteria and promoting horizontal gene transfer.
Microplastics enhance the prevalence of antibiotic resistance genes in mariculture sediments by enriching host bacteria and promoting horizontal gene transfer.
Lactobacillus delbrueckii subsp. allosunkii and lactis as emerging human uropathogens in elderly patients.
Two L. delbrueckii isolates exhibited tetracycline resistance due to the presence of the tet(W) gene, which encodes a ribosomal protection protein. The study highlights the emergence of L. delbrueckii as a uropathogen in elderly patients, with most isolates showing susceptibility to various antibiotics except for intrinsic resistance to fosfomycin and metronidazole.
First WGS Characterization of Streptococcus suis Isolated From a Case of Human Meningitis in Southern Italy.
The study identified the presence of tetracycline resistance gene tet(W) and macrolide-lincosamide-streptogramin resistance gene erm(B) in a Streptococcus suis strain isolated from a human case of meningitis in Italy. Additionally, a mutation in the pbp1a gene was found to be responsible for penicillin resistance.
Human milk oligosaccharide metabolism and antibiotic resistance in early gut colonizers: insights from bifidobacteria and lactobacilli in the maternal-infant microbiome.
The study investigated the metabolism of human milk oligosaccharides (HMOs) by bifidobacteria and lactobacilli isolated from human milk and mother-infant fecal samples, along with their antibiotic resistance profiles. Bifidobacterium bifidum showed the highest HMO degradation capability and was the most antibiotic-susceptible species, whereas Bifidobacterium animalis subsp. lactis was resistant to most tested antibiotics.
Comprehensive genome catalog analysis of the resistome, virulome and mobilome in the wild rodent gut microbiota.
The study identified numerous antibiotic resistance genes (ARGs) in the gut microbiota of wild rodents, including genes conferring resistance to elfamycin, tetracycline, and glycopeptides. Notable ARGs include Cdif_EFTu_ELF, Ecol_EFTu_KIR, Efac_EFTu_GE2A, Saur_fusA_FA, and Cdif_rpoB_RIF, which were found to be widely distributed among rodent gut microbiomes.
Occurrence and Drivers of Antibiotic Resistance Genes Carried by Bacteriophages in Soils Following Different Fertilization Treatments.
The study identified 19 pARG subtypes in soils with different fertilization treatments, highlighting the impact of organic fertilizers on the diversity and abundance of antibiotic resistance genes carried by bacteriophages.
The impact of green spaces, urban settings, seasonal changes, and pollutants on dissemination of antimicrobial genes in air.
The study identified several antimicrobial resistance genes (ARGs) in airborne samples, including blaTEM, mecA, aac(6')-Ib, ermB, ermC, tetM, tetW, sul1, and sul3. It found that the relative abundance of these ARGs varied with vegetation coverage, seasons, and environmental factors. High vegetation areas showed slightly lower ARG abundance compared to urban heat islands and low/no vegetation areas. The study highlights the potential of planting non-allergenic vegetation to reduce airborne ARG dissemination.
Application of MALDI-TOF MS and FT-IR spectroscopy in identification and antibiotic resistance profiling of lactic acid bacteria.
The study demonstrates the correlation between FT-IR spectral profiles and antibiotic resistance in lactic acid bacteria, highlighting the utility of these techniques for rapid resistance detection.
Genomic epidemiology and antimicrobial resistance of Corynebacterium macclintockiae, the predominant species of human pathogens within the Corynebacterium jeikeium complex.
The study identifies several AMR genes in Corynebacterium macclintockiae, including bla Coryne-A, tet(W), erm(X), and ant(2'')-Ia, which confer resistance to various antibiotics. These genes were experimentally validated through whole-genome sequencing and antimicrobial susceptibility testing.
Isolation and Molecular Characterization of Antimicrobial-Resistant Bacteria from Vegetable Foods.
The study identified several antimicrobial resistance genes in Enterobacteriaceae isolated from vegetables, including TEM, CTX-M IV, SHV, OXA, CMY II, DHA, tetA, tetW, sul-I, and qnrD, which confer resistance to beta-lactams, tetracyclines, sulfonamides, and quinolones.
Population structure and antimicrobial resistance of Corynebacterium diphtheriae in Victoria, Australia.
The study identified multiple AMR genes and mutations in contemporary Corynebacterium diphtheriae isolates from Victoria, Australia, including pbp2m, erm(X), aph(3')-Ia, aph(6)-Id, aph(3'')-Ib, tet(W), tet(33), tet(O), cmx, sul1, dfrA15, and mutations in gyrA and rpoB. These genes and mutations confer resistance to various antimicrobials such as penicillin, erythromycin, gentamicin, tetracycline, chloramphenicol, sulfamethoxazole, trimethoprim, ciprofloxacin, and rifampicin.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
Temporal dynamics of the resistome in gilts raised in an organic operation in which semen used for artificial insemination is the primary source of antimicrobial exposure.
The study identified several tetracycline, aminoglycoside, and MLS resistance genes in the fecal microbiome of gilts, with no significant increases in ARG abundance following exposure to semen extenders containing antibiotics.
Commensal Clostridia in the preterm gut as reservoirs of antimicrobial resistance: susceptibility profiles, and resistance genes.
The study identifies tetracycline and clindamycin resistance genes (tet and erm) in various Clostridia species from preterm infants, highlighting their role as reservoirs of antimicrobial resistance.
Cervicovaginal microbiome composition and absolute quantity are associated with pelvic inflammatory disease.
The study found that PID cases were associated with higher abundance of G. vaginalis and other CST IV organisms, while controls had higher levels of L. crispatus. No specific AMR genes were characterized in this paper.
Genomic and phenotypic diversity among taxonomically ambiguous clinical Corynebacterium isolates.
The study identified multiple AMR genes, including erm(X), tet(W), and aminoglycoside modifying enzymes, in various Corynebacterium species, highlighting extensive antimicrobial resistance in clinical isolates.
Genomic and Phenotypic Landscape of Antibiotic Resistance in Gut Lactic Acid Bacteria from Livestock Environments.
The study identified multiple antibiotic resistance genes in lactic acid bacteria (LAB) from livestock environments, including van(T), erm(B), cat(A), tet(W), lsa(D), arr, van(Y), and qac(G). These genes conferred resistance to various antibiotics, highlighting the potential for horizontal gene transfer and the importance of monitoring LAB for AMR.
Elucidation of population-based bacterial adaptation to antimicrobial treatment by single-cell sequencing analysis of the gut microbiome of a hospital patient.
The study identified 29 ARG subtypes across eight types in 13 known, five unknown, and 18 unclassified species, highlighting the complex and dynamic nature of antimicrobial resistance in the gut microbiome. Notably, the cfr(C) gene was detected in 11 bacterial species following antimicrobial treatment, with mutation patterns characterized in several species.
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