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tet(X3.9)

tetracycline resistance protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to tet(X3.9)

Browse AMR rules for tet(X3.9)

Overview

Mechanism: reduced the MIC of tigecycline by 2-fold
Drug Classes: tigecycline
Organisms: Acinetobacter variabilis, Acinetobacter schindleri, Escherichia coli
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	G74C	reduced the MIC of tigecycline by 2-fold	Acinetobacter variabilis, Acinetobacter schindleri, Escherichia coli	tigecycline	Reslit	Candidate

Papers1

1

Identification of Novel tet(X3) Variants Resistant To Tigecycline in Acinetobacter Species.

PMID 36409072 · 2022

Mutation Information

tet(X3.9): c.G74C

Nucleotide Change: G74C
Organisms: Acinetobacter variabilis, Acinetobacter schindleri, Escherichia coli
Confers Resistance To: tigecycline
Effect on Function: reduced the MIC of tigecycline by 2-fold
Validation Method: functional analysis
Source Database: Reslit