Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline inactivation enzyme
Overview
Emergence of mcr-9.1 in Extended-Spectrum-β-Lactamase-Producing Clinical Enterobacteriaceae in Pretoria, South Africa: Global Evolutionary Phylogenomics, Resistome, and Mobilome.
Emergence of mcr-9.1 in Extended-Spectrum-β-Lactamase-Producing Clinical Enterobacteriaceae in Pretoria, South Africa: Global Evolutionary Phylogenomics, Resistome, and Mobilome.
Emergence of mcr-9.1 in Extended-Spectrum-β-Lactamase-Producing Clinical Enterobacteriaceae in Pretoria, South Africa: Global Evolutionary Phylogenomics, Resistome, and Mobilome.
Emergence of Carbapenem- and Tigecycline-Resistant Proteus cibarius of Animal Origin.
The study identifies tet(X6) and blaNDM-1 as responsible for tigecycline and carbapenem resistance in Proteus cibarius strains isolated from chicken feces, highlighting the potential public health risk posed by these resistance mechanisms.
Rapid Detection of High-Level Tigecycline Resistance in Tet(X)-Producing Escherichia coli and Acinetobacter spp. Based on MALDI-TOF MS.
The study developed a MALDI-TOF MS-based assay to rapidly detect Tet(X)-producing E. coli and Acinetobacter spp. by identifying a unique peak of an oxygen-modified derivative of tigecycline. The assay showed high sensitivity (99.19%) and specificity (100%).
Acquisition and Spread of Antimicrobial Resistance: A tet(X) Case Study.
The study highlights the emergence and spread of tet(X) genes, which confer resistance to various tetracyclines, including next-generation ones. These genes are primarily acquired through mobile genetic elements and have been found in multiple bacterial species, including pathogens.
Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance.
The study identifies five key residue changes (L282S, A339T, D340N, V350I, and K351E) in Tet(X2) that enhance tigecycline resistance, demonstrating their critical role in the molecular evolution of Tet(X) towards high-level resistance.
Sporadic Dissemination of tet(X3) and tet(X6) Mediated by Highly Diverse Plasmidomes among Livestock-Associated Acinetobacter.
The study identifies tet(X3) and tet(X6) as prevalent tetracycline resistance genes in livestock-associated Acinetobacter, highlighting their sporadic dissemination and the role of diverse plasmidomes in their spread.
Source Tracking and Global Distribution of the Tigecycline Non-Susceptible tet(X).
The study identifies novel tet(X) orthologs, including tet(X45), tet(X46), and tet(X47), which confer resistance to tigecycline and other tetracycline derivatives. It also traces the origins of tet(X) genes to Riemerella anatipestifer and highlights the role of Bacteroidaceae as a reservoir for these genes.
Occurrence and Molecular Characterization of Abundant tet(X) Variants Among Diverse Bacterial Species of Chicken Origin in Jiangsu, China.
The study identified four tet(X) variants (tet(X3), tet(X4), tet(X6), and tet(X15)) in diverse bacterial species from chicken fecal samples, highlighting the widespread occurrence of tigecycline resistance in poultry farms.
Whole genome sequencing of the multidrug-resistant Chryseobacterium indologenes isolated from a patient in Brazil.
The study identified multiple antibiotic resistance genes and mutations in a multidrug-resistant Chryseobacterium indologenes strain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and efflux pumps, contributing to resistance against various antibiotics.
Classification and molecular characteristics of tet(X)-carrying plasmids in Acinetobacter species.
The study identifies and characterizes tet(X)-carrying plasmids in Acinetobacter species, highlighting the role of GR31 plasmids in mediating tigecycline resistance and their potential to spread among various Acinetobacter species.
Widespread Dissemination of Plasmid-Mediated Tigecycline Resistance Gene tet(X4) in Enterobacterales of Porcine Origin.
The study identifies the plasmid-mediated tigecycline resistance gene tet(X4) in various Enterobacterales from porcine origins, highlighting its widespread dissemination and coexistence with other resistance genes such as blaNDM-1 and cfr. It also reports the first occurrence of tet(X4) in Morganella morganii and its coexistence with blaNDM-1 in a Klebsiella quasipneumoniae strain.
Emergence of an Extensive Drug Resistant Pseudomonas aeruginosa Strain of Chicken Origin Carrying bla(IMP-45), tet(X6), and tmexCD3-toprJ3 on an Inc(pRBL16) Plasmid.
The study identified a multidrug-resistant Pseudomonas aeruginosa strain carrying blaIMP-45, tet(X6), and tmexCD3-toprJ3 on an Inc(pRBL16) plasmid, highlighting the potential of such plasmids as reservoirs for resistance genes.
Distribution Patterns of Antibiotic Resistance Genes and Their Bacterial Hosts in a Manure Lagoon of a Large-Scale Swine Finishing Facility.
The study identified multiple antibiotic resistance genes (ARGs) in manure samples from a swine finishing facility, highlighting the prevalence of resistance to tetracyclines, macrolides, aminoglycosides, and other antibiotics. Key genes included tet(M), lnuA, erm(35), aadS, mphB, dfrG, vga-type ABC-F, lsa-type ABC-F, msr-type ABC-F, optrA, and others, primarily found in Firmicutes, Proteobacteria, and Bacteroidota. These genes were associated with resistance mechanisms such as target alteration, antibiotic inactivation, and efflux pumps.
Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases.
Tet(X6) confers resistance to all generations of tetracycline antibiotics and is inhibited by anhydrotetracycline, which acts as a competitive substrate.
Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases.
Tet(X6) confers resistance to all generations of tetracycline antibiotics and is inhibited by anhydrotetracycline, which acts as a competitive substrate.
Myroides species, pathogenic spectrum and clinical microbiology sight in Mexican isolates.
The study identified multiple AMR genes in Myroides spp. isolates, including beta-lactamases (blaIMP-27, blaIMP-35, blaGOB-16, blaMUS-1, blaOXA-229, blaOXA-351, blaOXA-97), erythromycin esterase (ereB), and polymyxin resistance genes (mcr-3.6, mcr-3.7, mcr-3.10), indicating a high level of multidrug resistance.
Escherichia coli from six European countries reveals differences in profile and distribution of critical antimicrobial resistance determinants within One Health compartments, 2013 to 2020.
The study identified various AMR genes in E. coli isolates from different sources in six European countries, highlighting differences in resistance profiles and the prevalence of specific resistance mechanisms such as beta-lactamases, quinolone resistance genes, and tetracycline resistance genes.
ICECleSHZ29: Novel Integrative and Conjugative Element (ICE)-Carrying Tigecycline Resistance Gene tet(X6) in Chryseobacterium lecithinasegens.
The study identifies a novel integrative and conjugative element (ICE), ICE Cle SHZ29, carrying the tigecycline resistance gene tet(X6) in a multidrug-resistant Chryseobacterium lecithinasegens strain, SHZ29. The gene tet(X6) was found to confer high-level tigecycline resistance, while tet(X2) was non-functional in this strain.
Comparative genomics reveals avian Acinetobacter baumannii as antimicrobial resistance reservoirs and bovine strains with elevated pathogenicity.
Avian Acinetobacter baumannii strains were found to carry a significantly higher number of antimicrobial resistance genes compared to bovine and porcine strains, highlighting their potential role in the dissemination of antimicrobial resistance through animal origin foods.
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