Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline resistance protein
Overview
Source Tracking and Global Distribution of the Tigecycline Non-Susceptible tet(X).
The study identifies novel tet(X) orthologs, including tet(X45), tet(X46), and tet(X47), which confer resistance to tigecycline and other tetracycline derivatives. It also traces the origins of tet(X) genes to Riemerella anatipestifer and highlights the role of Bacteroidaceae as a reservoir for these genes.
The tetracycline resistome is shaped by selection for specific resistance mechanisms by each antibiotic generation.
The study identifies specific tetracycline resistance mechanisms (efflux pumps, ribosomal protection proteins, and type 1 tetracycline destructases) that are preferentially selected by different generations of tetracycline antibiotics, highlighting the evolutionary dynamics of resistance.
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