Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline efflux MFS transporter TetA(P)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| TetA(P) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 22 | TETRACYCLINE, DOXYCYCLINE +3 | Clostridium perfringens +9 | Europe, Australia|Belgium, Australia, China, Houston, TX, coastal environments|coastal regions, Saudi Arabia | 1994, 2001, 2011, 2019, 2020, 2021, 2023, 2024, 2025 | AB001076.1 | BAA19230.1 |
| tetA(P) | Card DatabaseResFinder Database | 2 | TETRACYCLINE, DOXYCYCLINE | Clostridium perfringens | - | 2001 | L20800.1 | AAA20116.1 |
| tet(A)(P) | Reslit | 1 | tetracycline | C. perfringens +3 | Global | 2020 | - | - |
| tetA[P] | Reslit | 1 | tetracycline | Clostridium perfringens | Japan | 2025 | NSUB001450|DRA017675 | - |
Tetracycline-resistance genes of Clostridium perfringens, Clostridium septicum and Clostridium sordellii isolated from cattle affected with malignant edema.
Tetracycline-resistance genes of Clostridium perfringens, Clostridium septicum and Clostridium sordellii isolated from cattle affected with malignant edema.
Transcriptional analysis of the tet(P) operon from Clostridium perfringens.
The study identifies and characterizes the tetA(P) and tetB(P) genes from the Clostridium perfringens tetracycline resistance determinant, which are part of an operon transcribed from a single promoter, P3. Both genes contribute to tetracycline resistance through different mechanisms: tetA(P) mediates active efflux, while tetB(P) provides ribosomal protection.
Environmental macrolide-lincosamide-streptogramin and tetracycline resistant bacteria.
The paper discusses the characterization of environmental macrolide-lincosamide-streptogramin (MLS) and tetracycline resistance genes, highlighting the diversity and distribution of these genes in environmental bacteria. It identifies several MLS resistance genes such as erm(H), erm(I), erm(N), and others, as well as tetracycline resistance genes like tetA(P), tet(V), and tet(X).
Necrotic enteritis-derived Clostridium perfringens strain with three closely related independently conjugative toxin and antibiotic resistance plasmids.
The study identifies three closely related independently conjugative plasmids in a necrotic enteritis strain of Clostridium perfringens, including plasmids carrying the netB toxin gene, tetracycline resistance gene tetA(P), and the beta2 toxin gene cpb2.
Paeniclostridium sordellii and Clostridioides difficile encode similar and clinically relevant tetracycline resistance loci in diverse genomic locations.
The study identified that approximately 20-30% of Paeniclostridium sordellii isolates are resistant to tetracyclines, including doxycycline, and that this resistance is mediated by the Tet P determinant, which is found in variable genomic locations. Additionally, the Tet P determinant was also found in human clinical isolates of Clostridioides difficile.
Independent Microevolution Mediated by Mobile Genetic Elements of Individual Clostridium difficile Isolates from Clade 4 Revealed by Whole-Genome Sequencing.
The study identified multiple antimicrobial resistance genes, including aac(6')-Ib, ermB, tetM, and catD, in Clostridium difficile isolates from clade 4, highlighting the role of mobile genetic elements in the evolution of multidrug resistance.
Manure and Doxycycline Affect the Bacterial Community and Its Resistome in Lettuce Rhizosphere and Bulk Soil.
The study identified the tetracycline resistance gene tetA(P) as being highly enriched in manure-treated soil and rhizosphere, particularly in doxycycline-treated bulk soil, indicating its potential as a marker for soil contamination by antibiotic-resistant bacteria and antibiotics.
Antimicrobial Resistance in Clostridium and Brachyspira spp. and Other Anaerobes.
The paper describes the antimicrobial resistance mechanisms in Clostridium and Brachyspira spp. and other anaerobes, focusing on the genetic basis of resistance to various antibiotics, including tetracyclines, macrolides, lincosamides, chloramphenicol, and others. It highlights the role of specific genes such as tet, erm, and cat in conferring resistance.
In Vitro Activity of Omadacycline, a New Tetracycline Analog, and Comparators against Clostridioides difficile.
Omadacycline showed potent in vitro activity against Clostridioides difficile isolates, with no significant differences in MIC values based on ribotype, disease severity, or vancomycin susceptibility. The study identified the presence of tetA(P) and tetB(P) resistance genes in one isolate, but these did not affect omadacycline MIC.
The distribution of antibiotic resistance genes in chicken gut microbiota commensals.
The study identified various tetracycline resistance genes including tet(W), tet(Q), tet(32), tet(O), tet(44), tetA(P), and tetB(P) in chicken gut microbiota commensals, highlighting their distribution across different bacterial families.
Enrichment of antibiotic resistant genes and pathogens in face masks from coastal environments.
The study identified 64 antibiotic-resistance genes (ARGs) and 12 mobile gene elements (MGEs) in the plastisphere of face masks, with significant enrichments in tetracycline, multidrug, macrolide-lincosamide-streptogramin B (MLSB), and phenicol-resistant genes compared to sediments.
Extensive genome analysis identifies novel plasmid families in Clostridium perfringens.
The study identified novel plasmid families in Clostridium perfringens, including a novel conjugative locus (Bcp) and several antimicrobial resistance genes such as tetA(P) and tetB(P).
Genomic Insights into Virulence Factors and Multi-Drug Resistance in Clostridium perfringens IRMC2505A.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant Clostridium perfringens IRMC2505A strain, including NimB, TetB(P), fabV, TetA(P), gidB, FabK-like, and mprF, which confer resistance to tetracycline and defensin-like cationic antimicrobial peptides.
Molecular characteristics and phylogenetic analysis of Clostridium perfringens from different regions in China, from 2013 to 2021.
The study identified various AMR genes in Clostridium perfringens isolates from China, including mprF, tetA(P), tetB(P), ErmQ, LnuP, AAC(6′)-Ie-APH(2″)-Ia, ANT(6)-Ib, tet44, and ErmB, which confer resistance to antibiotics such as penicillin, tetracycline, clindamycin, and aminoglycosides.
Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China.
The study identifies various antimicrobial resistance genes in Clostridioides difficile isolates from children, including those conferring resistance to aminoglycosides, macrolides, fluoroquinolones, glycopeptides, lincosamides, tetracyclines, and others. Notably, the pCD-METRO plasmid and vanA/B were not detected, indicating alternative resistance mechanisms.
Size Distribution and Pathogenic Potential of Culturable Airborne Clostridium spp. in a Suburb of Toyama City, Japan.
The study identified several antimicrobial resistance genes in Clostridium perfringens isolates, including mprF, tetA[P], tetB[P], erm[Q], cfrC, and mef[A]. These genes confer resistance to defensin, tetracycline, erythromycin, linezolid, phenicol, and macrolide antibiotics.
Genomic insights into tigecycline non-susceptibility in Clostridioides difficile: the role of the Tet P determinant and efflux mechanisms.
The study identifies the Tet P determinant, consisting of tetA(P) and tetB(P), as a genetic factor associated with reduced tigecycline susceptibility in C. difficile. These genes mediate resistance to tetracycline and minocycline with substrate specificity.
Genome MLST scheme for tracing genetic diversity and multidrug resistance of food animal-derived Clostridium perfringens.
The study identified tetracycline resistance genes tetA(P) and tetB(P) as the most prevalent in C. perfringens isolates, along with other resistance genes such as erm(Q) and lnu(P).
Lignocellulose degradation capabilities and distribution of antibiotic resistance genes and virulence factors in Clostridium from the gut of giant pandas.
The study identified 19 antibiotic resistance genes (ARGs) in Clostridium species from the gut of giant pandas, including glycopeptide resistance genes (vanG, vanH, vanR, vanT, vanW, vanX, vanY), tetracycline resistance genes (tet(Q), tetA(P), tetB(P)), multidrug resistance genes (cplR, sdrM, ermQ), and disinfectant resistance genes (qacG, qacJ).
The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants.
The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants.
The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants.
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