Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline-resistant ribosomal protection protein
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| tetB(P) | Card DatabaseResFinder Database | 2 | MINOCYCLINE, TETRACYCLINE +1 | Clostridium perfringens | - | 2006 | L20800.1 | AAA20117.1 |
| TetB(P) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 24 | tetracycline, MINOCYCLINE +4 | Clostridium perfringens +14 | Europe, Hong Kong, China, Australia, Houston, TX, Sweden|India|Global, South Korea, Saudi Arabia, China, International Space Station, China|Xinjiang, Bangladesh, Northwest China | 2001, 2005, 2011, 2019, 2020, 2021, 2023, 2024, 2025 | M85225|X56353|X04388|X75073|U08812|U58986|L12241|L12242|M21136|X90939|L09756|X92946|Y07780|M20925|M18896|AJ222769|Z21523|U73497|L33696|Y08615|X58717|L42544|L20800|M74049|X53401 | AAA20117.1 |
| tetB (P) | Reslit | 1 | tetracycline | Pandoraea sp. XY-2 | Changsha | 2019 | CP030849 | - |
| tetBP | Reslit | 2 | tetracycline | Elizabethkingia meningoseptica +1 | USA, Yangtze River Mouth, China | 2019, 2023 | MCJH00000000|MDTZ00000000|MDTY00000000 | - |
| tet(B)(P) | Reslit | 1 | tetracycline | C. perfringens +3 | Global | 2020 | - | - |
| tetB[P] | Reslit | 1 | tetracycline | Clostridium perfringens | Japan | 2025 | NSUB001450|DRA017675 | - |
Molecular ecology of tetracycline resistance: development and validation of primers for detection of tetracycline resistance genes encoding ribosomal protection proteins.
The study identified and characterized multiple tetracycline resistance genes encoding ribosomal protection proteins (RPPs) including tet(M), tet(O), tet(W), tet(Q), tet(S), tet(T), tetB(P), and otrA. These genes were detected in various bacterial species and environments, highlighting their prevalence and potential for horizontal gene transfer.
Transcriptional analysis of the tet(P) operon from Clostridium perfringens.
The study identifies and characterizes the tetA(P) and tetB(P) genes from the Clostridium perfringens tetracycline resistance determinant, which are part of an operon transcribed from a single promoter, P3. Both genes contribute to tetracycline resistance through different mechanisms: tetA(P) mediates active efflux, while tetB(P) provides ribosomal protection.
Update on acquired tetracycline resistance genes.
Update on acquired tetracycline resistance genes.
Update on acquired tetracycline resistance genes.
Functional identification of conjugation and replication regions of the tetracycline resistance plasmid pCW3 from Clostridium perfringens.
Environmental macrolide-lincosamide-streptogramin and tetracycline resistant bacteria.
The paper discusses the characterization of environmental macrolide-lincosamide-streptogramin (MLS) and tetracycline resistance genes, highlighting the diversity and distribution of these genes in environmental bacteria. It identifies several MLS resistance genes such as erm(H), erm(I), erm(N), and others, as well as tetracycline resistance genes like tetA(P), tet(V), and tet(X).
Plasmid metagenome reveals high levels of antibiotic resistance genes and mobile genetic elements in activated sludge.
The study identified several antibiotic resistance genes, including tetB(P), aadA5, ampC, macB, IS Pps1, and IS Sm2, in the plasmid metagenome of activated sludge, highlighting the presence of diverse resistance mechanisms in environmental microbial communities.
Whole Genome Sequencing and Comparative Genomics Analyses of Pandoraea sp. XY-2, a New Species Capable of Biodegrade Tetracycline.
The study identifies two tetracycline resistance genes, tetR and tetG, in Pandoraea sp. XY-2, suggesting its capability to biodegrade tetracycline.
Paeniclostridium sordellii and Clostridioides difficile encode similar and clinically relevant tetracycline resistance loci in diverse genomic locations.
The study identified that approximately 20-30% of Paeniclostridium sordellii isolates are resistant to tetracyclines, including doxycycline, and that this resistance is mediated by the Tet P determinant, which is found in variable genomic locations. Additionally, the Tet P determinant was also found in human clinical isolates of Clostridioides difficile.
Comparative genomic analyses reveal diverse virulence factors and antimicrobial resistance mechanisms in clinical Elizabethkingia meningoseptica strains.
The study identified multiple antimicrobial resistance genes in Elizabethkingia meningoseptica strains, including beta-lactamases, tetracycline resistance genes, and efflux pumps, indicating a multidrug-resistant profile.
Antimicrobial Resistance in Clostridium and Brachyspira spp. and Other Anaerobes.
The paper describes the antimicrobial resistance mechanisms in Clostridium and Brachyspira spp. and other anaerobes, focusing on the genetic basis of resistance to various antibiotics, including tetracyclines, macrolides, lincosamides, chloramphenicol, and others. It highlights the role of specific genes such as tet, erm, and cat in conferring resistance.
In Vitro Activity of Omadacycline, a New Tetracycline Analog, and Comparators against Clostridioides difficile.
Omadacycline showed potent in vitro activity against Clostridioides difficile isolates, with no significant differences in MIC values based on ribotype, disease severity, or vancomycin susceptibility. The study identified the presence of tetA(P) and tetB(P) resistance genes in one isolate, but these did not affect omadacycline MIC.
Comprehensive screening of genomic and metagenomic data reveals a large diversity of tetracycline resistance genes.
The study identified 17 novel tetracycline resistance genes, including enzymatic degradation, ribosomal protection, and efflux pump genes, which conferred resistance in E. coli. These genes were found in various environments and showed potential for horizontal gene transfer.
The distribution of antibiotic resistance genes in chicken gut microbiota commensals.
The study identified various tetracycline resistance genes including tet(W), tet(Q), tet(32), tet(O), tet(44), tetA(P), and tetB(P) in chicken gut microbiota commensals, highlighting their distribution across different bacterial families.
Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins.
The study identifies several ribosomal protection protein (RPP) genes, including tet(M), tet(O), tet(W), tet(Q), tetB(P), and otr(A), that can confer high-level tetracycline resistance in E. coli. However, expression of these genes often comes with fitness costs, and certain mutations in tRNA genes (argW and proL) or the hns gene can mitigate these costs.
Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection.
Nine Clostridioides difficile strains isolated from Korean patients were analyzed, revealing diverse antibiotic resistance genes including those conferring resistance to erythromycin, clindamycin, glycopeptides, fluoroquinolones, aminoglycosides, and tetracyclines.
Extensive genome analysis identifies novel plasmid families in Clostridium perfringens.
The study identified novel plasmid families in Clostridium perfringens, including a novel conjugative locus (Bcp) and several antimicrobial resistance genes such as tetA(P) and tetB(P).
Genomic Insights into Virulence Factors and Multi-Drug Resistance in Clostridium perfringens IRMC2505A.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant Clostridium perfringens IRMC2505A strain, including NimB, TetB(P), fabV, TetA(P), gidB, FabK-like, and mprF, which confer resistance to tetracycline and defensin-like cationic antimicrobial peptides.
Molecular characteristics and phylogenetic analysis of Clostridium perfringens from different regions in China, from 2013 to 2021.
The study identified various AMR genes in Clostridium perfringens isolates from China, including mprF, tetA(P), tetB(P), ErmQ, LnuP, AAC(6′)-Ie-APH(2″)-Ia, ANT(6)-Ib, tet44, and ErmB, which confer resistance to antibiotics such as penicillin, tetracycline, clindamycin, and aminoglycosides.
Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes.
Five novel bacterial species were isolated from the International Space Station (ISS) and characterized. These species, Arthrobacter burdickii, Leifsonia virtsii, Leifsonia williamsii, Paenibacillus vandeheii, and Sporosarcina highlanderae, were identified through phylogenomic, phenotypic, and functional analyses. Their genomes were sequenced, and they were distinguished from known species using ANI and dDDH values, as well as gyrB gene sequence similarities.
Assessing the nonlinear association of environmental factors with antibiotic resistance genes (ARGs) in the Yangtze River Mouth, China.
The study identified tetBP, ampr, and tetO as key antibiotic resistance genes associated with environmental factors in the Yangtze River Mouth. High concentrations of amoxicillin, phosphorus, chromium, manganese, calcium, and strontium were linked to increased ARG abundance.
Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China.
The study identifies various antimicrobial resistance genes in Clostridioides difficile isolates from children, including those conferring resistance to aminoglycosides, macrolides, fluoroquinolones, glycopeptides, lincosamides, tetracyclines, and others. Notably, the pCD-METRO plasmid and vanA/B were not detected, indicating alternative resistance mechanisms.
Size Distribution and Pathogenic Potential of Culturable Airborne Clostridium spp. in a Suburb of Toyama City, Japan.
The study identified several antimicrobial resistance genes in Clostridium perfringens isolates, including mprF, tetA[P], tetB[P], erm[Q], cfrC, and mef[A]. These genes confer resistance to defensin, tetracycline, erythromycin, linezolid, phenicol, and macrolide antibiotics.
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.
Comprehensive genomic analysis reveals virulence and antibiotic resistance genes in a multidrug-resistant Bacillus cereus isolated from hospital wastewater in Bangladesh.
The study identified several AMR genes in a multidrug-resistant Bacillus cereus strain isolated from hospital wastewater, including beta-lactamases (BcII, BcIII, BcI), glycopeptide resistance genes (vanW, vanY, vanT), tetracycline resistance gene (tetB(P)), fosfomycin resistance gene (fosB), and efflux pump genes (bcrA, bcrB, ykkCD, qacJ).
Genomic insights into tigecycline non-susceptibility in Clostridioides difficile: the role of the Tet P determinant and efflux mechanisms.
The study identifies the Tet P determinant, consisting of tetA(P) and tetB(P), as a genetic factor associated with reduced tigecycline susceptibility in C. difficile. These genes mediate resistance to tetracycline and minocycline with substrate specificity.
Genome MLST scheme for tracing genetic diversity and multidrug resistance of food animal-derived Clostridium perfringens.
The study identified tetracycline resistance genes tetA(P) and tetB(P) as the most prevalent in C. perfringens isolates, along with other resistance genes such as erm(Q) and lnu(P).
Epidemiology and genetic characteristics of Clostridioides difficile isolates in Northwest China.
The study identified 13 resistance genes, including cdeA, ermB, 23S rRNA, vanXYG, tetM, and tetB(P), along with mutations in gyrA, gyrB, and rpoB, conferring resistance to fluoroquinolones, macrolides, lincosamides, glycopeptides, tetracyclines, and rifamycins in Clostridioides difficile isolates from Northwest China.
Lignocellulose degradation capabilities and distribution of antibiotic resistance genes and virulence factors in Clostridium from the gut of giant pandas.
The study identified 19 antibiotic resistance genes (ARGs) in Clostridium species from the gut of giant pandas, including glycopeptide resistance genes (vanG, vanH, vanR, vanT, vanW, vanX, vanY), tetracycline resistance genes (tet(Q), tetA(P), tetB(P)), multidrug resistance genes (cplR, sdrM, ermQ), and disinfectant resistance genes (qacG, qacJ).
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