Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline-metal/H+ antiporter
Overview
Two types of Bacillus subtilis tetA(L) deletion strains reveal the physiological importance of TetA(L) in K+ acquisition as well as in Na+, Alkali, and Tetracycline Resistance.
The study identifies the chromosomally encoded TetA(L) protein of Bacillus subtilis as a multifunctional tetracycline-metal/H+ antiporter that also exhibits monovalent cation/H+ antiport activity and a net K+ uptake mode. The gene tetA(L) confers resistance to tetracycline by catalyzing the efflux of a tetracycline-divalent metal ion complex in exchange for protons.
The purified Bacillus subtilis tetracycline efflux protein TetA(L) reconstitutes both tetracycline–cobalt/H+ and Na+(K+)/H+ exchange.
The study characterizes the Bacillus subtilis tetracycline efflux protein TetA(L), demonstrating its ability to reconstitute tetracycline-cobalt/H+ and Na+/H+ exchange, indicating its role in tetracycline resistance through efflux mechanisms.
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