tktB

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transketolase beta subunit

NCBI Pathogen Isolates

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UniProt

Protein entries specific to tktB

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Validation StatusCandidate

Overview

Validation Method: measured colistin MICs of mutants from AB5075 transposon library
Drug Classes: polymyxins
Organisms: Acinetobacter baumannii ATCC 19606
Papers: 1
Databases: Reslit

Papers1

Metabolic Responses to Polymyxin Treatment in Acinetobacter baumannii ATCC 19606: Integrating Transcriptomics and Metabolomics with Genome-Scale Metabolic Modeling.

PMID 30746493 · 2019

The study identified tktB as a gene involved in metabolic responses to colistin treatment in Acinetobacter baumannii ATCC 19606, with a 4-fold increase in colistin MIC when tktB was disrupted.

Gene Information

Gene Name: tktB
Allele: tktB
Encodes: transketolase beta subunit
Source Database: Reslit
Confers Resistance To: polymyxins
Organisms Tested In: • Acinetobacter baumannii ATCC 19606
Validation Method: measured colistin MICs of mutants from AB5075 transposon library

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tktB

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tktB

Gene Information