Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
bleomycin family antibiotic N-acetyltransferase TlmB
Overview
The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics.
BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.
BlmB and TlmB are N-acetyltransferases that provide resistance to the bleomycin family of antitumor antibiotics by acetylating the metal-free forms of bleomycin, tallysomycin, phleomycin, and zorbamycin. These genes were experimentally validated to confer resistance in vivo and in vitro.
No comments yet. Be the first to comment!