tol c

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efflux pump

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to tol c

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: PCR and sequencing
Drug Classes: tigecycline, fluoroquinolones, aminoglycosides, beta lactams
Organisms: Klebsiella pneumoniae
Geographic Location: Brazil
Papers: 1
Databases: Reslit

Papers1

High Prevalence of Multidrug-Resistant Klebsiella pneumoniae Harboring Several Virulence and β-Lactamase Encoding Genes in a Brazilian Intensive Care Unit.

PMID 30723463 · 2018

The study identified a high prevalence of multidrug-resistant Klebsiella pneumoniae isolates carrying various β-lactamase genes (bla KPC, bla TEM, bla SHV, bla OXA-1, and bla CTX-M-1) and efflux pump genes (AcrAB, tol C, mdt K) along with outer membrane porin genes (Omp K35 and Omp K36).

Gene Information

Gene Name: tol c
Allele: tol C
Encodes: efflux pump
Source Database: Reslit
Confers Resistance To: tigecyclinefluoroquinolonesaminoglycosidesbeta lactams
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Brazil
Validation Method: PCR and sequencing
Sequence Accession: MK106173|MK106174|MK106175|MK106176|MK106177|MK106178|MK106179|MK106180|MK106181|MK106182|MK106183|MK106184|MK106185|MK106186|MK106187

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tol c

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tol c

Gene Information