tolc1

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outer membrane protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

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UniProt

Protein entries specific to tolc1

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: MIC-P and MBC-B assays
Drug Classes: novobiocin, ceftazidime, lincomycin, nalidixic acid, kanamycin, tetracycline, fluoroquinolones, acriflavine
Organisms: Actinobacillus pleuropneumoniae
Papers: 1
Databases: Reslit

Papers1

A TolC-Like Protein of Actinobacillus pleuropneumoniae Is Involved in Antibiotic Resistance and Biofilm Formation.

PMID 27822201 · 2016

The study identifies TolC1 as a critical component of the multidrug efflux machinery in Actinobacillus pleuropneumoniae, contributing to antibiotic resistance in both planktonic and biofilm cells. Deletion of tolC1 leads to increased susceptibility to various antibiotics and non-antibiotic antimicrobials.

Gene Information

Gene Name: tolc1
Allele: tolC1
Encodes: outer membrane protein
Source Database: Reslit
Confers Resistance To: novobiocinceftazidimelincomycinnalidixic acidkanamycintetracyclinefluoroquinolonesacriflavine
Organisms Tested In: • Actinobacillus pleuropneumoniae
Validation Method: MIC-P and MBC-B assays
Sequence Accession: KU705812|KU705813

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tolc1

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tolc1

Gene Information