topA

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Topoisomerase I

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to topA

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: reduces its activity
Validation Method: positive selection analysis
Drug Classes: quinolones, kanamycin
Organisms: Pseudomonas aeruginosa, Escherichia coli
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S180L	-	reduces its activity	Escherichia coli	kanamycin	Reslit	Candidate

Papers2

Evolutionary Genomics of Niche-Specific Adaptation to the Cystic Fibrosis Lung in Pseudomonas aeruginosa.

PMID 32898270 · 2021

The study identifies genes under positive selection in Pseudomonas aeruginosa strains isolated from the cystic fibrosis (CF) lung, highlighting adaptations related to antibiotic resistance, metabolism, and stress response.

Gene Information

Gene Name: topA
Allele: topA
Encodes: Topoisomerase I
Source Database: Reslit
Confers Resistance To: quinolones
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: positive selection analysis

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topA

Mutations

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topA

Mutations

Gene Information