Browse AMR Genes

Explore antimicrobial resistance genes from the literature

toprJ1

efflux pump component

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to toprJ1

Browse AMR rules for toprJ1

Overview

Drug Classes: tigecycline
Organisms: Klebsiella pneumoniae
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q40R	-	-	Klebsiella pneumoniae	tigecycline	Reslit	Candidate

Papers1

1

Repurposing harmaline as a novel approach to reverse tmexCD1-toprJ1-mediated tigecycline resistance against klebsiella pneumoniae infections.

PMID 38790017 · 2024

Mutation Information

Protein Change: Q40R
Organisms: Klebsiella pneumoniae
Confers Resistance To: tigecycline
Validation Method: MIC testing
Source Database: Reslit