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tpr

putative tetratricopeptide (TPR) repeat-containing transport protein gene

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to tpr

Browse AMR rules for tpr

Overview

Drug Classes: linezolid, azithromycin
Organisms: Clostridium difficile, Treponema pallidum
Papers: 2
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
M439I	-	-	Clostridium difficile	linezolid	Reslit	Candidate
-	A2059G	-	Treponema pallidum	azithromycin	Reslit	Candidate

Papers2

1

Different Resistance Mechanisms for Cadazolid and Linezolid in Clostridium difficile Found by Whole-Genome Sequencing Analysis.

PMID 28584149 · 2017

Mutation Information

Protein Change: M439I
Organisms: Clostridium difficile
Confers Resistance To: linezolid
Validation Method: whole-genome sequencing
Source Database: Reslit

2

Gene subtype analysis of Treponema pallidum for drug resistance to azithromycin.

PMID 30116352 · 2018

Mutation Information

Nucleotide Change: A2059G
Organisms: Treponema pallidum
Confers Resistance To: azithromycin
Validation Method: antimicrobial susceptibility test
Source Database: Reslit