trfA

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glycopeptide resistance factor

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

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UniProt

Protein entries specific to trfA

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Validation StatusCandidate

Overview

Validation Method: generation of a trfA-knockout strain and demonstration that beta-lactam exposure of this mutated strain showed no capacity to induce vancomycin resistance
Drug Classes: vancomycin
Organisms: Staphylococcus aureus
Papers: 1
Databases: Reslit

Papers1

Exposure of Staphylococcus aureus to subinhibitory concentrations of β-lactam antibiotics induces heterogeneous vancomycin-intermediate Staphylococcus aureus.

PMID 24957836 · 2014

Exposure of Staphylococcus aureus to subinhibitory concentrations of beta-lactam antibiotics can induce heterogeneous vancomycin-intermediate Staphylococcus aureus (h-VISA). The trfA gene is required for this induction.

Gene Information

Gene Name: trfA
Allele: trfA
Encodes: glycopeptide resistance factor
Source Database: Reslit
Confers Resistance To: vancomycin
Organisms Tested In: • Staphylococcus aureus
Validation Method: generation of a trfA-knockout strain and demonstration that beta-lactam exposure of this mutated strain showed no capacity to induce vancomycin resistance

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trfA

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trfA

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