ttgR

transcriptional repressor

Overview

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
H70A	-	-	-	phenicols	Reslit	Candidate
H72A	-	-	-	phenicols	Reslit	Candidate
R75A	-	-	-	phenicols	Reslit	Candidate

Papers1

Domain cross-talk during effector binding to the multidrug binding TTGR regulator.

Mutations in the effector binding pocket of TtgR affect DNA binding and effector responsiveness.

Protein Change: H70A, H72A, R75A
Confers Resistance To: phenicols
Validation Method: electrophoretic mobility shift assay, isothermal titration calorimetry
Source Database: Reslit