tva(A)

Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to tva(A)

Browse AMR rules for tva(A)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target protection
Validation Method: whole genome sequencing and phenotypic susceptibility testing
Drug Classes: pleuromutilins, TIAMULIN, streptogramin a, tiamulin, valnemulin
Organisms: Brachyspira hyodysenteriae, Escherichia coli, Staphylococcus aureus
Geographic Location: England|Wales, United Kingdom
Alleles: 2
Papers: 3
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
tva(A)	Card DatabaseResFinder Database	2	TIAMULIN	Brachyspira hyodysenteriae	-	2018	LT970863.1	SOX29786.1
Tva(A)	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	6	pleuromutilins, TIAMULIN +3	Brachyspira hyodysenteriae +2	United Kingdom, England\|Wales	2018, 2019, 2021	PRJEB24023	SOX29786.1

Papers3

1

Gene Information

Gene Name: tva(A)
Allele: tva(A)
Encodes: Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins
Source Database: Card Database
Mechanism: antibiotic target protection
Organisms Tested In: • Brachyspira hyodysenteriae
Sequence Accession: LT970863.1
Protein Accession: SOX29786.1
Notes: ARO:3004730

2

Identification of a New Antimicrobial Resistance Gene Provides Fresh Insights Into Pleuromutilin Resistance in Brachyspira hyodysenteriae, Aetiological Agent of Swine Dysentery.

PMID 29971045 · 2018

The study identifies a novel pleuromutilin resistance gene, tva(A), in Brachyspira hyodysenteriae, which confers reduced pleuromutilin susceptibility and contributes to the development of higher-level resistance via mutations in ribosome-associated genes.

Gene Information

Gene Name: tva(A)
Allele: Tva(A)
Encodes: ABC-F transporter
Source Database: Reslit
Confers Resistance To: pleuromutilins
Organisms Tested In: • Brachyspira hyodysenteriae
Geographic Location: United Kingdom
Validation Method: whole genome sequencing and phenotypic susceptibility testing
Sequence Accession: PRJEB24023

3

Identification of a New Antimicrobial Resistance Gene Provides Fresh Insights Into Pleuromutilin Resistance in Brachyspira hyodysenteriae, Aetiological Agent of Swine Dysentery.

PMID 29971045 · 2018

Gene Information

Gene Name: tva(A)
Allele: Tva(A)
Encodes: ABC-F type ribosomal protection protein Tva(A)
Source Database: Reference Gene Catalog
Mechanism: Target protection
Confers Resistance To: TIAMULIN
Organisms Tested In: • Brachyspira hyodysenteriae
Sequence Accession: LT970863.1
Protein Accession: SOX29786.1
Notes: ABC transporter

4

Identification of a New Antimicrobial Resistance Gene Provides Fresh Insights Into Pleuromutilin Resistance in Brachyspira hyodysenteriae, Aetiological Agent of Swine Dysentery.

PMID 29971045 · 2018

Gene Information

Gene Name: tva(A)
Allele: Tva(A)
Encodes: ABC-F type ribosomal protection protein Tva(A)
Source Database: ResFinder Database
Mechanism: Target protection
Confers Resistance To: TIAMULIN
Organisms Tested In: • Brachyspira hyodysenteriae
Sequence Accession: LT970863.1
Protein Accession: SOX29786.1
Notes: ABC transporter

5

Identification of a New Antimicrobial Resistance Gene Provides Fresh Insights Into Pleuromutilin Resistance in Brachyspira hyodysenteriae, Aetiological Agent of Swine Dysentery.

PMID 29971045 · 2018

Gene Information

Gene Name: tva(A)
Allele: Tva(A)
Encodes: ABC-F type ribosomal protection protein Tva(A)
Source Database: Card Database
Mechanism: Target protection
Confers Resistance To: TIAMULIN
Organisms Tested In: • Brachyspira hyodysenteriae
Sequence Accession: LT970863.1
Protein Accession: SOX29786.1
Notes: ABC transporter

6

Identification of a New Antimicrobial Resistance Gene Provides Fresh Insights Into Pleuromutilin Resistance in Brachyspira hyodysenteriae, Aetiological Agent of Swine Dysentery.

PMID 29971045 · 2018

Gene Information

Gene Name: tva(A)
Allele: tva(A)
Source Database: ResFinder Database
Mechanism: Target protection
Confers Resistance To: TIAMULIN
Sequence Accession: SOX29786
Notes: ABC transporter

7

The tva(A) Gene from Brachyspira hyodysenteriae Confers Decreased Susceptibility to Pleuromutilins and Streptogramin A in Escherichia coli.

PMID 31307989 · 2019

The tva(A) gene from Brachyspira hyodysenteriae confers decreased susceptibility to pleuromutilins and streptogramin A in Escherichia coli and to a lesser extent in Staphylococcus aureus.

Gene Information

Gene Name: tva(A)
Allele: Tva(A)
Encodes: ABC-F protein
Source Database: Reslit
Confers Resistance To: pleuromutilinsstreptogramin a
Organisms Tested In: • Escherichia coli
• Staphylococcus aureus
Validation Method: expression in E. coli and S. aureus with increased MICs

8

Whole-Genome Sequencing of Brachyspira hyodysenteriae Isolates From England and Wales Reveals Similarities to European Isolates and Mutations Associated With Reduced Sensitivity to Antimicrobials.

PMID 34531838 · 2021

The study identified the pleuromutilin resistance gene tva(A) and mutations in 23S rRNA (G2032A) and L3 protein (N148S) associated with reduced susceptibility to tiamulin and valnemulin in Brachyspira hyodysenteriae isolates.

Gene Information

Gene Name: tva(A)
Allele: Tva(A)
Encodes: pleuromutilin resistance gene
Source Database: Reslit
Confers Resistance To: tiamulinvalnemulin
Organisms Tested In: • Brachyspira hyodysenteriae
Geographic Location: England|Wales
Validation Method: genomic analysis and MIC testing
Sequence Accession: PRJNA731465

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