tyrA

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Tyrosine biosynthesis enzyme

NCBI Pathogen Isolates

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UniProt

Protein entries specific to tyrA

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Validation StatusCandidate

Overview

Mechanism: Disruption of amino acid biosynthesis leads to decreased gentamicin tolerance
Validation Method: Transposon sequencing (Tn-Seq) and competition assays
Drug Classes: gentamicin
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Genetic basis of persister tolerance to aminoglycosides in Escherichia coli.

PMID 25852159 · 2015

The study identifies several genes involved in persister tolerance to gentamicin in Escherichia coli, including genes related to the electron transport chain, flagellar formation, and amino acid biosynthesis. Disruption of these genes affects gentamicin tolerance, highlighting their roles in persister formation.

Gene Information

Gene Name: tyrA
Allele: tyrA
Encodes: Tyrosine biosynthesis enzyme
Source Database: Reslit
Mechanism: Disruption of amino acid biosynthesis leads to decreased gentamicin tolerance
Confers Resistance To: gentamicin
Organisms Tested In: • Escherichia coli
Validation Method: Transposon sequencing (Tn-Seq) and competition assays

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tyrA

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tyrA

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