Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
regulatory protein for uhpT
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R78C | - | - | Escherichia coli | fosfomycin | Reslit | Candidate |
| G469R | - | - | - | fosfomycin | Reslit | Candidate |
| G97D | - | single resistance variant, DNA-binding response regulator UhpA | Escherichia coli | fosfomycin | Card DatabaseReference Gene Catalog | Candidate |
Characterization of Fosfomycin and Nitrofurantoin Resistance Mechanisms in Escherichia coli Isolated in Clinical Urine Samples.
The study identifies fosA3 as a novel plasmid-mediated fosfomycin resistance gene in E. coli isolates in Spain. Fosfomycin resistance is primarily due to defects in the UhpT transporter system, while nitrofurantoin resistance involves mutations in nfsA, nfsB, and ribE genes.
Pervasive Selection for Clinically Relevant Resistance and Media Adaptive Mutations at Very Low Antibiotic Concentrations.
The study identifies clinically relevant resistance mutations in E. coli under subMIC antibiotic concentrations, showing that mutations in glpT, uhpT, uhpC, uhpA, nfsA, nfsB, gyrA, gyrB, and envZ confer resistance to fosfomycin, nitrofurantoin, ciprofloxacin, and tetracycline.
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