Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
inner membrane protein sensing glucose 6-phosphate
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| A393V | - | - | Klebsiella pneumoniae | fosfomycin | Reslit | Candidate |
| F384L | - | disruption of G6P-mediated induction of uhpT expression | Escherichia coli | fosfomycin | Reslit | Candidate |
| F112L | - | - | Escherichia coli, Citrobacter freundii | fosfomycin | Reslit | Candidate |
| T72P | - | - | - | fosfomycin | Reslit | Candidate |
Pervasive Selection for Clinically Relevant Resistance and Media Adaptive Mutations at Very Low Antibiotic Concentrations.
The study identifies clinically relevant resistance mutations in E. coli under subMIC antibiotic concentrations, showing that mutations in glpT, uhpT, uhpC, uhpA, nfsA, nfsB, gyrA, gyrB, and envZ confer resistance to fosfomycin, nitrofurantoin, ciprofloxacin, and tetracycline.
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