uppP

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Undecaprenyl pyrophosphate phosphatase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to uppP

AMR Rules

Browse AMR rules for uppP

Validation StatusCandidate

Overview

Mechanism: resistance to bacitracin
Validation Method: Tn-seq data and upregulation signatures
Drug Classes: bacitracin
Organisms: Staphylococcus aureus, Arcobacter butzleri 55
Geographic Location: shellfish
Papers: 2
Databases: Reslit

Papers2

Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic.

PMID 29662210 · 2018

The study identifies several AMR genes involved in resistance to various antibiotics, including murA, murJ, fabI, norA, lmrB2/3, emrA, yhgE, lmrB2, fosB, uppP, vraRS, and mprF, through Tn-seq data and upregulation signatures.

Gene Information

Gene Name: uppP
Allele: uppP
Encodes: Undecaprenyl pyrophosphate phosphatase
Source Database: Reslit
Mechanism: resistance to bacitracin
Confers Resistance To: bacitracin
Organisms Tested In: • Staphylococcus aureus
Validation Method: Tn-seq data and upregulation signatures

Genomic Characterization of Arcobacter butzleri Isolated From Shellfish: Novel Insight Into Antibiotic Resistance and Virulence Determinants.

PMID 31057492 · 2019

The study identified several antibiotic resistance genes in Arcobacter butzleri strains isolated from shellfish, including genes conferring resistance to beta-lactams, polymyxin, chloramphenicol, tetracycline, and macrolides.