Browse AMR Genes

Explore antimicrobial resistance genes from the literature

uppS

Undecaprenyl pyrophosphate synthase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to uppS

Browse AMR rules for uppS

Validation StatusCandidate

Overview

Mechanism: lipid carrier for peptidoglycan synthesis
Validation Method: sequence comparison and prevalence analysis
Drug Classes: vancomycin
Organisms: Staphylococcus aureus
Geographic Location: Taiwan
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
K101E	-	-	Staphylococcus aureus	vancomycin	Reslit	Candidate

Papers1

1

Novel single-nucleotide variations associated with vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.

PMID 29403293 · 2018

Three novel SNVs in htrA, upps, and fmtC genes are associated with vancomycin resistance in VISA and hVISA isolates.

Gene Information

Gene Name: uppS
Allele: upps
Encodes: Undecaprenyl pyrophosphate synthase
Source Database: Reslit
Mechanism: lipid carrier for peptidoglycan synthesis
Confers Resistance To: vancomycin
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Taiwan
Validation Method: sequence comparison and prevalence analysis

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