uvrC

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DNA repair endonuclease

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to uvrC

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: knock-out mutant analysis and MIC testing
Drug Classes: mitomycin c
Organisms: Staphylococcus aureus
Geographic Location: Europe
Papers: 1
Databases: Reslit

Papers1

Combination therapy delays antimicrobial resistance after adaptive laboratory evolution of Staphylococcus aureus.

PMID 40084881 · 2025

The study identified mutations in genes such as rpoB, gyrA, parC, grlA, parE, grlB, mprF, cls2, vraS, vraT, walK, walR, mgrA, cap8B, uvrB, and azo1 that are associated with resistance to rifampicin, ciprofloxacin, daptomycin, vancomycin, and mitomycin C in Staphylococcus aureus after adaptive laboratory evolution.

Gene Information

Gene Name: uvrC
Allele: uvrC
Encodes: DNA repair endonuclease
Source Database: Reslit
Confers Resistance To: mitomycin c
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Europe
Validation Method: knock-out mutant analysis and MIC testing
Sequence Accession: NCBI Sequence Read Archive (SRA) accession numbers|SAMN46357333|SAMN46357334|SAMN46357335|SAMN46357336|SAMN46357337|SAMN46357338|SAMN46357339|SAMN46357340|SAMN46357341|SAMN46357342|SAMN46357343|SAMN46357344|SAMN46357345|SAMN46357346|SAMN46357347|SAMN46357348|SAMN46357349|SAMN46357350|SAMN46357351|SAMN46357352|SAMN46357353|SAMN46357354|SAMN46357355|SAMN46357356|SAMN46357357|SAMN46357358|SAMN46357359|SAMN46357360|SAMN46357361|SAMN46357362

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uvrC

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uvrC

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