The study identifies and characterizes the vanD glycopeptide resistance gene cluster in Enterococcus faecium BM4339, including the genes vanD, vanX, vanY, vanH, intD, vanR, and vanS, which are involved in the resistance mechanism against glycopeptide antibiotics.

The study identifies the vanD gene cluster in Enterococcus faecium 10/96A, which confers vancomycin resistance through the synthesis of peptidoglycan precursors ending in d-Ala-d-Lac. A G184S mutation in the ddl gene impairs the d-Ala:d-Ala ligase, contributing to resistance.

The study identified a VanD-type vancomycin resistance operon in Enterococcus gallinarum N04-0414, which is responsible for high-level vancomycin resistance. The strain lacks the ddl2 gene, which is typically found downstream of the vanC operon in other E. gallinarum strains.

The study reports the first VanD-type vancomycin-resistant Enterococcus raffinosus isolate, GV5, which exhibits high-level resistance to vancomycin and teicoplanin due to the presence of the vanD operon.

The study identifies vanD and vanG-like gene clusters in a novel Ruminococcus species isolated from human bowel flora, demonstrating resistance to vancomycin and teicoplanin.

The study developed a nanoplex PCR assay for the simultaneous detection of vancomycin and bifunctional aminoglycoside resistance genes in Enterococcus species, including vanA, vanB, vanC, vanD, and aacA-aphD.

The study demonstrates the utility of HMM-GRASPx for profiling antimicrobial resistance (AMR) gene families in metagenomic data sets, highlighting the distinct resistome profiles across different body sites and the importance of AMR gene abundance in understanding bacterial communities.

The study explores the complex resistomes of Paenibacillaceae, revealing diverse antibiotic resistance mechanisms including intrinsic and acquired resistance genes such as aadD2, vanA, vanB, vanC, vanD, vanE, vanF, vanG, mcr, bla, tet, qnr, erm, mph, lnu, lsa, vat, vgb, cat, cfr, optrA, poxtA, sul, dfr, mexAB-OprM, acrAB-TolC, and oqxAB.

The study identified vanD-mediated vancomycin resistance in Enterococcus faecium isolates, highlighting the presence of vanD in rectal swabs and the need for broader screening strategies.

The study identified several β-lactamase and vancomycin resistance genes that were significantly increased in placebo-treated patients compared to ribaxamase-treated patients following ceftriaxone exposure.

The study presents a nanosensor-based assay for detecting antimicrobial resistance mutations and genes, including ampR D135G and G154R mutations and vanA, vanB, and vanD genes in Pseudomonas aeruginosa and Enterococcus faecium.

The study identifies a novel vanD-subtype (vanD6) in VanD-type vancomycin-resistant enterococci, along with three novel vanD-containing genomic islands (GIs) integrated at the same chromosomal site in both Enterococcus faecium and Enterococcus casseliflavus.

The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.

The study evaluated the accuracy of whole-genome sequencing (WGS) for predicting antimicrobial resistance in enterococcal clinical isolates. It identified several AMR genes and mutations, including aac(6')-aph(2"), erm(B), erm(T), tet(L), tet(M), vanA, vanB, vanD, optrA, poxtA, and mutations in gyrA and parC, which were validated through genomic sequencing and phenotypic AST.

The paper discusses the genetic basis of antibiotic resistance mechanisms in Enterococcus and Staphylococcus aureus, focusing on various resistance genes and mutations associated with glycopeptides, aminoglycosides, beta-lactams, macrolides, lincosamides, streptogramins, quinolones, tetracyclines, and fosfomycin.

The study identified vancomycin-resistant Enterococcus faecalis and Enterococcus faecium strains with vanA, vanB, and vanD genotypes. These strains exhibited higher biofilm-forming capacity compared to susceptible strains.

The study identifies the de novo emergence of vanD vancomycin-resistant Enterococcus faecium (VREfm) and characterizes the genomic changes, including the acquisition of a vanD-containing integrative conjugative element (ICE) and disruption of the native ddl ligase, which contribute to vancomycin resistance.

The study identified vancomycin-resistant genes (vanA, vanB, vanC, vanD, vanE, vanG) in intrinsically antibiotic-resistant bacteria from the gut microbiota of Indonesian individuals, highlighting the potential role of these bacteria in the spread of antibiotic resistance through horizontal gene transfer.

The study identified various AMR genes in zoo animal microbiomes, including resistance to tetracyclines, lincomamides, fluoroquinolones, vancomycin, beta-lactams, and aminoglycosides.

The study identified multiple van genes (vanA, vanB, vanD) in glycopeptide non-susceptible Staphylococcus aureus isolates, highlighting the presence of resistance mechanisms that contribute to in vitro MIC creep phenomena.

The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.

The study identified several antibiotic resistance genes in Enterococcus spp. isolated from mussels, including tetC, tetD, cfr, vanA, vanD, vatE, vatD, and qnrS, which confer resistance to tetracycline, linezolid, vancomycin, and fluoroquinolone.

The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.