Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Van ligase;glycopeptide resistance gene cluster
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D200N | - | - | Enterococcus faecalis | glycopeptides | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| vanE | Card Database | 1 | - | Enterococcus faecalis | - | - | FJ872411.1 | AAL27442.1 |
| VanE | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 16 | vancomycin, VANCOMYCIN +1 | Enterococcus faecalis BM4405 +20 | Canada, China|Canada|UK, Global, Nigeria, Indonesia, China, China|Xinjiang, Mayurbhanj, Odisha, India|India | 1999, 2001, 2002, 2005, 2017, 2018, 2022, 2023, 2024, 2025 | AF136925 | AAL27442.1 |
VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405.
The study identifies VanE, a new acquired glycopeptide resistance gene in Enterococcus faecalis BM4405, which confers resistance to vancomycin through the synthesis of peptidoglycan precursors ending in d-Ala-d-Ser.
VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405.
Consequences of VanE-Type Resistance on Efficacy of Glycopeptides In Vitro and in Experimental Endocarditis Due to Enterococcus faecalis.
The study characterizes the VanE-type glycopeptide resistance in Enterococcus faecalis, demonstrating that it leads to low-level resistance to vancomycin while maintaining susceptibility to teicoplanin.
Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada.
The vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 was characterized, revealing a low-level vancomycin resistance mechanism through alteration of peptidoglycan precursors.
Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada.
Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada.
Silencing of glycopeptide resistance in Enterococcus faecalis BM4405 by novobiocin.
The study identified mutations in the vanE operon and gyrB gene of Enterococcus faecalis BM4405-1, which led to silencing of glycopeptide resistance. The vanE operon, including vanE, vanXYE, and vanTE, was found to confer vancomycin resistance when cloned into a susceptible strain. The mutation in gyrB (K337Y) was linked to altered DNA supercoiling and reduced expression of the vanE operon.
Genome characterization of a novel binary toxin-positive strain of Clostridium difficile and comparison with the epidemic 027 and 078 strains.
The study identified several antibiotic resistance genes in the ST201 strains of Clostridium difficile, including vancomycin resistance operons (VanA, VanB, VanG, VanE), virginiamycin A acetyltransferase, multidrug resistance efflux pumps, bacitracin resistance genes, tetracycline resistance genes, and fluoroquinolone resistance genes.
The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.
The study explores the complex resistomes of Paenibacillaceae, revealing diverse antibiotic resistance mechanisms including intrinsic and acquired resistance genes such as aadD2, vanA, vanB, vanC, vanD, vanE, vanF, vanG, mcr, bla, tet, qnr, erm, mph, lnu, lsa, vat, vgb, cat, cfr, optrA, poxtA, sul, dfr, mexAB-OprM, acrAB-TolC, and oqxAB.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Vancomycin Resistance in Enterococcus and Staphylococcus aureus.
The paper discusses the genetic basis of antibiotic resistance mechanisms in Enterococcus and Staphylococcus aureus, focusing on various resistance genes and mutations associated with glycopeptides, aminoglycosides, beta-lactams, macrolides, lincosamides, streptogramins, quinolones, tetracyclines, and fosfomycin.
Antibiotic resistance in potential probiotic lactic acid bacteria of fermented foods and human origin from Nigeria.
The study identified various antibiotic resistance genes including aac(6')-Ii, ermB, ermC, tetM, vanE, and parC in lactic acid bacteria from Nigerian fermented foods and human sources.
Detection of Vancomycin Resistant Genes in Intrinsically Antibiotic Resistant Bacteria from the Gut Microbiota of Indonesian Individuals.
The study identified vancomycin-resistant genes (vanA, vanB, vanC, vanD, vanE, vanG) in intrinsically antibiotic-resistant bacteria from the gut microbiota of Indonesian individuals, highlighting the potential role of these bacteria in the spread of antibiotic resistance through horizontal gene transfer.
Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.
This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.
Unveiling community structure, antimicrobial resistance, and virulence factor of a wastewater sample of dairy farm located in mayurbhanj, odisha, india.
The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
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