Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
dehydrogenase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| VanH | Reference Gene CatalogReslit | 23 | glycopeptides, vancomycin +2 | Enterococcus faecium BM4339 +19 | Ontario, Global, Stockholm|Sweden, Hangzhou, China, Italy, Scotland, Mayurbhanj, Odisha, India|India | 1993, 1996, 1998, 1999, 2001, 2003, 2005, 2007, 2009, 2014, 2015, 2016, 2020, 2021, 2022, 2023, 2024, 2025 | AF130997|AF130998 | AAY52012.1 |
| vanH-Ac2 | Reslit | 1 | glycopeptides | Mycobacteroides abscessus complex | - | 2022 | - | - |
Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.
The study characterizes the vanD glycopeptide resistance gene cluster in Enterococcus faecium BM4339, identifying several genes including vanD, vanH, vanX, vanY, vanR, and vanS, which collectively confer resistance to glycopeptide antibiotics through the synthesis of d-alanyl-d-lactate-terminating peptidoglycan precursors.
Regulation of Expression of the vanD Glycopeptide Resistance Gene Cluster from Enterococcus faecium BM4339.
The study identifies and characterizes the vanD glycopeptide resistance gene cluster in Enterococcus faecium BM4339, including the genes vanD, vanX, vanY, vanH, intD, vanR, and vanS, which are involved in the resistance mechanism against glycopeptide antibiotics.
VanD-Type Vancomycin-Resistant Enterococcus faecium 10/96A.
The study identifies the vanD gene cluster in Enterococcus faecium 10/96A, which confers vancomycin resistance through the synthesis of peptidoglycan precursors ending in d-Ala-d-Lac. A G184S mutation in the ddl gene impairs the d-Ala:d-Ala ligase, contributing to resistance.
Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.
Resistance to glycopeptide antibiotics in the teicoplanin producer is mediated by van gene homologue expression directing the synthesis of a modified cell wall peptidoglycan.
The study identifies the vanH, vanA, and vanX genes in Actinoplanes teichomyceticus, which are responsible for glycopeptide resistance by modifying cell wall peptidoglycan precursors, leading to resistance against teicoplanin and vancomycin.
Fitness cost of VanA-type vancomycin resistance in methicillin-resistant Staphylococcus aureus.
The study characterizes the VanA-type vancomycin resistance in methicillin-resistant Staphylococcus aureus, highlighting the fitness cost associated with the acquisition of the vanA operon.
Peptidoglycan Cross-Linking in Glycopeptide-Resistant Actinomycetales.
The study identifies vanH, vanA, vanX, vanK, and a metallo-d,d-carboxypeptidase as key genes involved in glycopeptide resistance in Actinomycetales through peptidoglycan cross-linking mechanisms.
Relationship between glycopeptide production and resistance in the actinomycete Nonomuraea sp. ATCC 39727.
The study identifies vanY_n as a gene encoding a d,d-carboxypeptidase that contributes to glycopeptide resistance in Nonomuraea sp. ATCC 39727 by modifying peptidoglycan precursors.
Vancomycin-Variable Enterococcal Bacteremia
The study reports a case of vancomycin-variable Enterococcus (VVE) bacteremia, highlighting the challenges in diagnosing and treating VVE due to its ability to develop resistance to vancomycin despite initial susceptibility. The VVE isolates were found to possess the vanA gene, which is responsible for vancomycin resistance.
Chlorhexidine Induces VanA-Type Vancomycin Resistance Genes in Enterococci.
Chlorhexidine induces the expression of VanA-type vancomycin resistance genes in Enterococcus faecium and Enterococcus faecalis, including vanH, vanA, vanX, vanY, and vanZ, which are part of the vancomycin resistance gene cluster.
ARIBA: Rapid identification of antimicrobial resistance genes and variants from whole-genome sequencing data
The paper presents ARIBA, a tool for identifying antimicrobial resistance genes and mutations from sequencing data. It evaluates the performance of ARIBA on three datasets, demonstrating its accuracy and efficiency in detecting resistance genes and mutations in Enterococcus faecium, Shigella sonnei, and Neisseria gonorrhoeae.
Raman-activated sorting of antibiotic-resistant bacteria in human gut microbiota.
The study identified several antibiotic resistance genes (ARGs) in human gut microbiota, including beta-lactam resistance genes (PBP-1A and PBP-2X) and vancomycin resistance genes (vanG, vanH, vanR, and vanU). These genes were found in various bacterial species and were linked to the resistance phenotypes of the bacteria.
Revealing antimicrobial resistance in stormwater with MinION.
The study identified several AMR genes in stormwater samples from Stockholm, including aac(3)-X, aac(6')-I, aph(3')-I, aph(3')-IIb, bacA, chloramphenicol, rosA, ermO, abeS, major facilitator superfamily transporter, mexE, mexX, ompR, opcM, oprA, oprN, qacG, puromycin, ADP-ribosylating, dfrA12, vanH, vanR, and vanS, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, fosmidomycin, MLS, multidrug, puromycin, rifamycin, trimethoprim, and vancomycin.
Fecal Microbiota Transplant in Cirrhosis Reduces Gut Microbial Antibiotic Resistance Genes: Analysis of Two Trials.
Fecal microbiota transplant (FMT) reduces the abundance of antibiotic resistance genes (ARGs) in patients with decompensated cirrhosis, particularly beta-lactamase and vancomycin resistance genes, regardless of the FMT route or pre-procedure antibiotics.
Effect of Vancomycin on Cytoplasmic Peptidoglycan Intermediates and van Operon mRNA Levels in VanA-Type Vancomycin-Resistant Enterococcus faecium.
The study characterizes the VanA-type vancomycin resistance mechanism in Enterococcus faecium, highlighting the role of the van operon genes (vanA, vanH, vanX, vanY, vanR, vanS) in replacing D-Ala-D-Ala with D-Ala-D-Lac in peptidoglycan, leading to vancomycin resistance.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Occurrence of vanHAX and Related Genes beyond the Actinobacteria Phylum.
The study identifies the presence of vanHAXRS and related genes in various bacterial classes beyond the Actinobacteria phylum, including Anaerolineae, Erysipelotrichia, Ktedonobacteria, Bacilli, and Clostridia. These genes are involved in glycopeptide resistance through cell-wall remodeling mechanisms.
Genomic Characterization of a Vancomycin-Resistant Strain of Enterococcus faecium Harboring a rep2 Plasmid.
The study identified a vancomycin-resistant Enterococcus faecium strain (SJ2) harboring the vanA gene on a rep2 plasmid. The strain exhibited resistance to multiple antibiotics, including vancomycin, and contained several other antimicrobial resistance genes.
Genetic analysis of vancomycin-variable Enterococcus faecium clinical isolates in Italy.
The study identifies vancomycin-variable Enterococcus faecium isolates (VVE Ita-S) in Italy, highlighting the presence of vanA gene clusters on plasmids and the potential for reversion to vancomycin resistance through deletions in the Tn 1546 transposon.
Metagenomics reveals fibre fermentation and AMR pathways in red grouse (Lagopus scotica) microbiota.
The study identified multiple vancomycin resistance genes, including vanW, vanG, vanT, vanY, vanXY, vanH, and others, in the caecal microbiota of red grouse. Additionally, a tetracycline resistance gene (adeF) and a metronidazole resistance gene (nimJ) were detected.
Unveiling community structure, antimicrobial resistance, and virulence factor of a wastewater sample of dairy farm located in mayurbhanj, odisha, india.
The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.
The study characterizes Tn1546, a transposon responsible for glycopeptide resistance in Enterococcus faecium BM4147, through the biosynthesis of depsipeptide peptidoglycan precursors involving genes vanA, vanH, and vanY.
Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story.
The study identifies five genes (vanA, vanH, vanX, vanS, and vanR) involved in vancomycin resistance in Enterococcus faecium BM4147, detailing their roles in modifying peptidoglycan precursors and activating resistance mechanisms.
Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms.
The study identifies and characterizes the vanH, vanA, and vanX genes from glycopeptide-producing organisms, which are responsible for glycopeptide resistance mechanisms similar to those found in vancomycin-resistant enterococci.
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