Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
peptidoglycan bridge formation peptidyltransferase VanK-I
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| VanK-I | Card DatabaseReference Gene Catalog | 2 | VANCOMYCIN | Desulfitobacterium hafniense Y51 | - | - | AP008230.1 | BAE85481.1 |
| vanK | Reslit | 1 | glycopeptides | Streptomyces coelicolor A(3)2 | - | 2014 | - | - |
| vanKI | Reslit | 1 | glycopeptides | Mycobacteroides abscessus complex | - | 2022 | - | - |
Peptidoglycan Cross-Linking in Glycopeptide-Resistant Actinomycetales.
The study identifies vanH, vanA, vanX, vanK, and a metallo-d,d-carboxypeptidase as key genes involved in glycopeptide resistance in Actinomycetales through peptidoglycan cross-linking mechanisms.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
No comments yet. Be the first to comment!