Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
glycopeptide resistance gene cluster;vanR
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| vanR_in_vanA_cl | Card Database | 1 | - | Enterococcus faecium | - | - | M97297.1 | AAA65953.1 |
| vanR | Reslit | 18 | glycopeptides, vancomycin | Enterococcus faecium BM4339 +19 | China, Global, Pittsburgh, PA, Stockholm|Sweden, Egypt, Ireland, Russia, Germany, Germany|USA|Europe|Asia|North America|Central America | 1996, 1998, 1999, 2001, 2015, 2018, 2020, 2021, 2022, 2023, 2024, 2025 | AF130997|AF130998 | - |
| VanR-A | Card DatabaseReference Gene CatalogReslit | 7 | VANCOMYCIN, vancomycin +1 | Paenibacillus thiaminolyticus +4 | Brazil, Chettia Chlef Hospital | 1995, 1998, 2005, 2022, 2023 | DQ018710.1 | AAY52002.1 |
| VanR | Reslit | 2 | vancomycin | Enterococcus durans +2 | South Africa, China | 2020, 2025 | MK086097|MK086099 | - |
| vanRA | Reslit | 1 | glycopeptides | Rothia nasimurium | China|Xinjiang | 2025 | JAYWIX000000000|CP056080 | - |
Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.
The study characterizes the vanD glycopeptide resistance gene cluster in Enterococcus faecium BM4339, identifying several genes including vanD, vanH, vanX, vanY, vanR, and vanS, which collectively confer resistance to glycopeptide antibiotics through the synthesis of d-alanyl-d-lactate-terminating peptidoglycan precursors.
Regulation of Expression of the vanD Glycopeptide Resistance Gene Cluster from Enterococcus faecium BM4339.
The study identifies and characterizes the vanD glycopeptide resistance gene cluster in Enterococcus faecium BM4339, including the genes vanD, vanX, vanY, vanH, intD, vanR, and vanS, which are involved in the resistance mechanism against glycopeptide antibiotics.
Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.
Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.
Competition between VanU(G) repressor and VanR(G) activator leads to rheostatic control of vanG vancomycin resistance operon expression.
VanU_G acts as a repressor of the vanG operon by binding to the PUG and PYG promoters, while VanR_G functions as an activator. The balance between these regulators enables rheostatic control of vancomycin resistance gene expression.
Transcriptional Response of Resistome to Composting and Its Implications for Antimicrobial Resistance Dissemination
The study identifies several tetracycline resistance genes (tetM, tetW, tetO, tetS), sulfonamide resistance genes (sulI, sulII), and others, showing their expression dynamics during composting and their association with microbial community shifts.
ARIBA: Rapid identification of antimicrobial resistance genes and variants from whole-genome sequencing data
The paper presents ARIBA, a tool for identifying antimicrobial resistance genes and mutations from sequencing data. It evaluates the performance of ARIBA on three datasets, demonstrating its accuracy and efficiency in detecting resistance genes and mutations in Enterococcus faecium, Shigella sonnei, and Neisseria gonorrhoeae.
Machine Learning Leveraging Genomes from Metagenomes Identifies Influential Antibiotic Resistance Genes in the Infant Gut Microbiome.
The study identifies class D beta-lactamase and vanR as influential antibiotic resistance genes in the infant gut microbiome, with class D beta-lactamase enriched in formula-fed infants and vanR associated with increased abundance after antibiotic treatment.
Raman-activated sorting of antibiotic-resistant bacteria in human gut microbiota.
The study identified several antibiotic resistance genes (ARGs) in human gut microbiota, including beta-lactam resistance genes (PBP-1A and PBP-2X) and vancomycin resistance genes (vanG, vanH, vanR, and vanU). These genes were found in various bacterial species and were linked to the resistance phenotypes of the bacteria.
Revealing antimicrobial resistance in stormwater with MinION.
The study identified several AMR genes in stormwater samples from Stockholm, including aac(3)-X, aac(6')-I, aph(3')-I, aph(3')-IIb, bacA, chloramphenicol, rosA, ermO, abeS, major facilitator superfamily transporter, mexE, mexX, ompR, opcM, oprA, oprN, qacG, puromycin, ADP-ribosylating, dfrA12, vanH, vanR, and vanS, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, fosmidomycin, MLS, multidrug, puromycin, rifamycin, trimethoprim, and vancomycin.
Complete Genomic Analysis of VRE From a Cattle Feedlot: Focus on 2 Antibiotic Resistance.
The study identified multiple antibiotic resistance genes in vancomycin-resistant enterococci (VRE) isolates from a cattle feedlot, including vanC1, vanC2/C3, vanXY-C, VanR, macA, macB, rlmA (II), erm(A), aac(6')-la, blaEC, tet(A), tet(L), S10p, gyrA, gyrB, msbA, S12p, rpoB, mdfA/cmr, liaF, liaR, liaS, bcrC, mprF, pgsA, ef-G, ef-TU, ddl, alr, kasA, isotRNA, inhA, fabl, murA, folA, and Dfr, which confer resistance to various antibiotics such as vancomycin, macrolides, aminoglycosides, β-lactams, tetracyclines, quinolones, and others.
Effect of Vancomycin on Cytoplasmic Peptidoglycan Intermediates and van Operon mRNA Levels in VanA-Type Vancomycin-Resistant Enterococcus faecium.
The study characterizes the VanA-type vancomycin resistance mechanism in Enterococcus faecium, highlighting the role of the van operon genes (vanA, vanH, vanX, vanY, vanR, vanS) in replacing D-Ala-D-Ala with D-Ala-D-Lac in peptidoglycan, leading to vancomycin resistance.
Genetic description of VanD phenotype vanA genotype in vancomycin-resistant Enterococcus faecium isolates from a Bone Marrow Transplantation Unit.
The study characterizes the genetic structure of vancomycin-resistant Enterococcus faecium isolates displaying a VanD phenotype with a vanA genotype, highlighting the presence of various resistance genes and genetic variations within the van transposon.
Inhibition of the Vancomycin Resistance in Staphylococcus aureus in Egypt Using Silver Nanoparticles.
The study identified the presence of vanA and vanR genes in vancomycin-resistant Staphylococcus aureus (VRSA) isolates in Egypt, confirming the existence of VRSA strains and demonstrating the effectiveness of silver nanoparticles in inhibiting these resistant strains.
Occurrence of vanHAX and Related Genes beyond the Actinobacteria Phylum.
The study identifies the presence of vanHAXRS and related genes in various bacterial classes beyond the Actinobacteria phylum, including Anaerolineae, Erysipelotrichia, Ktedonobacteria, Bacilli, and Clostridia. These genes are involved in glycopeptide resistance through cell-wall remodeling mechanisms.
Detection and Genomic Characterisation of Clostridioides difficile from Spinach Fields.
The study identified various antimicrobial resistance genes in C. difficile isolates from spinach and soil samples, including vanB, tet(M), ant(6)-Ia, qacG, cdeA, SAT-4, vanXY, vanR, D19aph(3')-III_1, tet(40), and CDD-1, indicating resistance to vancomycin, tetracyclines, aminoglycosides, disinfectants, fluoroquinolones, nucleosides, and beta-lactams.
Distribution Patterns of Antibiotic Resistance Genes and Their Bacterial Hosts in a Manure Lagoon of a Large-Scale Swine Finishing Facility.
The study identified multiple antibiotic resistance genes (ARGs) in manure samples from a swine finishing facility, highlighting the prevalence of resistance to tetracyclines, macrolides, aminoglycosides, and other antibiotics. Key genes included tet(M), lnuA, erm(35), aadS, mphB, dfrG, vga-type ABC-F, lsa-type ABC-F, msr-type ABC-F, optrA, and others, primarily found in Firmicutes, Proteobacteria, and Bacteroidota. These genes were associated with resistance mechanisms such as target alteration, antibiotic inactivation, and efflux pumps.
Clostridioides difficile in South American Camelids in Germany: First Insights into Molecular and Genetic Characteristics and Antimicrobial Resistance.
The study identified several AMR genes and mutations in C. difficile isolates from South American camelids in Germany, including bla_CDD-1, vanZ1, aadE, tet(M), tet(40), vanG, vanR, vanS, vanT, and mutations in gyrA and gyrB associated with fluoroquinolone resistance.
Draft genome sequencing data of Enterococcus faecium BT22, a vancomycin-resistant opportunistic pathogen isolated from hospital effluents.
The study identified 12 antibiotic resistance genes and one virulence gene in strain BT22, including genes conferring resistance to aminoglycosides, macrolides, tetracyclines, and vancomycin.
Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences.
The study identified several genetic determinants associated with reduced susceptibility to antimicrobial agents in Clostridioides difficile, including point mutations in rpoB, rpoC, marR, vanS, and vanR, as well as the plasmid pCD-METRO and the P nimB G promoter mutation. These findings highlight the rarity of antimicrobial resistance in C. difficile and emphasize the importance of updating resistance marker databases for accurate detection.
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.
Lignocellulose degradation capabilities and distribution of antibiotic resistance genes and virulence factors in Clostridium from the gut of giant pandas.
The study identified 19 antibiotic resistance genes (ARGs) in Clostridium species from the gut of giant pandas, including glycopeptide resistance genes (vanG, vanH, vanR, vanT, vanW, vanX, vanY), tetracycline resistance genes (tet(Q), tetA(P), tetB(P)), multidrug resistance genes (cplR, sdrM, ermQ), and disinfectant resistance genes (qacG, qacJ).
A severe Clostridioides difficile ribotype 027 infection in Beijing, China, july 2024.
The study identified vancomycin resistance mediated by a mutation in the VanR gene and metronidazole resistance associated with the nimB gene in a Clostridioides difficile ribotype 027 isolate.
The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin.
The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin.
Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story.
The study identifies five genes (vanA, vanH, vanX, vanS, and vanR) involved in vancomycin resistance in Enterococcus faecium BM4147, detailing their roles in modifying peptidoglycan precursors and activating resistance mechanisms.
Glycerol Monolaurate Inhibits Induction of Vancomycin Resistance in Enterococcus faecalis.
Glycerol monolaurate (GML) inhibits the induction of vancomycin resistance in Enterococcus faecalis by blocking signal transduction in the VanS-VanR pathway.
vanA gene cluster in a vancomycin-resistant clinical isolate of Bacillus circulans.
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