Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
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Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| vanS | Reslit | 13 | glycopeptides, vancomycin | Enterococcus faecium BM4339 +10 | Global, Stockholm|Sweden, Germany, Germany|USA|Europe|Asia|North America|Central America, Mayurbhanj, Odisha, India|India | 1996, 1998, 1999, 2001, 2015, 2020, 2021, 2022, 2023, 2024, 2025 | AF130997|AF130998 | - |
| VanS-A | Card DatabaseReference Gene CatalogReslit | 5 | vancomycin, teicoplanin +1 | Enterococcus faecium +2 | Brazil, Chettia Chlef Hospital | 1995, 1998, 2022, 2023 | QHLB00000000|MXAT00000000|QHLC00000000|QNUP00000000|MVGF00000000|MVGH00000000|QNUQ00000000|QHLD00000000|MVGJ00000000 | AAA65954.1 |
| vanSA | Reslit | 1 | glycopeptides | Mycobacteroides abscessus complex | - | 2022 | - | - |
Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.
The study characterizes the vanD glycopeptide resistance gene cluster in Enterococcus faecium BM4339, identifying several genes including vanD, vanH, vanX, vanY, vanR, and vanS, which collectively confer resistance to glycopeptide antibiotics through the synthesis of d-alanyl-d-lactate-terminating peptidoglycan precursors.
Regulation of Expression of the vanD Glycopeptide Resistance Gene Cluster from Enterococcus faecium BM4339.
The study identifies and characterizes the vanD glycopeptide resistance gene cluster in Enterococcus faecium BM4339, including the genes vanD, vanX, vanY, vanH, intD, vanR, and vanS, which are involved in the resistance mechanism against glycopeptide antibiotics.
Competition between VanU(G) repressor and VanR(G) activator leads to rheostatic control of vanG vancomycin resistance operon expression.
VanU_G acts as a repressor of the vanG operon by binding to the PUG and PYG promoters, while VanR_G functions as an activator. The balance between these regulators enables rheostatic control of vancomycin resistance gene expression.
ARIBA: Rapid identification of antimicrobial resistance genes and variants from whole-genome sequencing data
The paper presents ARIBA, a tool for identifying antimicrobial resistance genes and mutations from sequencing data. It evaluates the performance of ARIBA on three datasets, demonstrating its accuracy and efficiency in detecting resistance genes and mutations in Enterococcus faecium, Shigella sonnei, and Neisseria gonorrhoeae.
Revealing antimicrobial resistance in stormwater with MinION.
The study identified several AMR genes in stormwater samples from Stockholm, including aac(3)-X, aac(6')-I, aph(3')-I, aph(3')-IIb, bacA, chloramphenicol, rosA, ermO, abeS, major facilitator superfamily transporter, mexE, mexX, ompR, opcM, oprA, oprN, qacG, puromycin, ADP-ribosylating, dfrA12, vanH, vanR, and vanS, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, fosmidomycin, MLS, multidrug, puromycin, rifamycin, trimethoprim, and vancomycin.
Effect of Vancomycin on Cytoplasmic Peptidoglycan Intermediates and van Operon mRNA Levels in VanA-Type Vancomycin-Resistant Enterococcus faecium.
The study characterizes the VanA-type vancomycin resistance mechanism in Enterococcus faecium, highlighting the role of the van operon genes (vanA, vanH, vanX, vanY, vanR, vanS) in replacing D-Ala-D-Ala with D-Ala-D-Lac in peptidoglycan, leading to vancomycin resistance.
Genetic description of VanD phenotype vanA genotype in vancomycin-resistant Enterococcus faecium isolates from a Bone Marrow Transplantation Unit.
The study characterizes the genetic structure of vancomycin-resistant Enterococcus faecium isolates displaying a VanD phenotype with a vanA genotype, highlighting the presence of various resistance genes and genetic variations within the van transposon.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Occurrence of vanHAX and Related Genes beyond the Actinobacteria Phylum.
The study identifies the presence of vanHAXRS and related genes in various bacterial classes beyond the Actinobacteria phylum, including Anaerolineae, Erysipelotrichia, Ktedonobacteria, Bacilli, and Clostridia. These genes are involved in glycopeptide resistance through cell-wall remodeling mechanisms.
Clostridioides difficile in South American Camelids in Germany: First Insights into Molecular and Genetic Characteristics and Antimicrobial Resistance.
The study identified several AMR genes and mutations in C. difficile isolates from South American camelids in Germany, including bla_CDD-1, vanZ1, aadE, tet(M), tet(40), vanG, vanR, vanS, vanT, and mutations in gyrA and gyrB associated with fluoroquinolone resistance.
Draft genome sequencing data of Enterococcus faecium BT22, a vancomycin-resistant opportunistic pathogen isolated from hospital effluents.
The study identified 12 antibiotic resistance genes and one virulence gene in strain BT22, including genes conferring resistance to aminoglycosides, macrolides, tetracyclines, and vancomycin.
Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences.
The study identified several genetic determinants associated with reduced susceptibility to antimicrobial agents in Clostridioides difficile, including point mutations in rpoB, rpoC, marR, vanS, and vanR, as well as the plasmid pCD-METRO and the P nimB G promoter mutation. These findings highlight the rarity of antimicrobial resistance in C. difficile and emphasize the importance of updating resistance marker databases for accurate detection.
Identification of pathways to high-level vancomycin resistance in Clostridioides difficile that incur high fitness costs in key pathogenicity traits.
The study identifies two pathways to high-level vancomycin resistance in Clostridioides difficile, involving mutations in vanT and dacS, which lead to modifications in the muropeptide terminal D-Ala-D-Ala and dysregulation of the dacJRS cluster, respectively.
Unveiling community structure, antimicrobial resistance, and virulence factor of a wastewater sample of dairy farm located in mayurbhanj, odisha, india.
The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin.
The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin.
Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story.
The study identifies five genes (vanA, vanH, vanX, vanS, and vanR) involved in vancomycin resistance in Enterococcus faecium BM4147, detailing their roles in modifying peptidoglycan precursors and activating resistance mechanisms.
Glycerol Monolaurate Inhibits Induction of Vancomycin Resistance in Enterococcus faecalis.
Glycerol monolaurate (GML) inhibits the induction of vancomycin resistance in Enterococcus faecalis by blocking signal transduction in the VanS-VanR pathway.
vanA gene cluster in a vancomycin-resistant clinical isolate of Bacillus circulans.
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