vanXY-C

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D-Ala-D-Ala dipeptidase/D-Ala-D-Ala carboxypeptidase VanXY-C

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to vanXY-C

AMR Rules

Browse AMR rules for vanXY-C

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: cloning and MIC testing
Drug Classes: VANCOMYCIN, glycopeptides, vancomycin
Organisms: Enterococcus gallinarum, Enterococcus gallinarum BM4174, Escherichia coli, Enterococcus casseliflavus ATCC 25788, Enterococcus casseliflavus, Streptococcus salivarius subsp. thermophilus, Enterococcus durans
Geographic Location: Europe|Southern and Western Ireland, France|United Kingdom, South Africa
Alleles: 4
Papers: 8
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants4

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
VanXY-C	Card DatabaseReference Gene CatalogReslit	11	VANCOMYCIN, vancomycin	Enterococcus gallinarum +2	South Africa	1999, 2002, 2003, 2009, 2020	AF162694.1	AAF61331.1
vanXY_C	Reslit	2	glycopeptides, vancomycin	Enterococcus gallinarum BM4174 +2	France\|United Kingdom	2000, 2005	AF162694	-
vanXY C-2	Reslit	1	vancomycin	Enterococcus casseliflavus ATCC 25788	-	2002	AY033089	-
vanXYC	Reslit	1	glycopeptides	Streptococcus salivarius subsp. thermophilus	Europe\|Southern and Western Ireland	2019	PRJEB35062	-

Papers8

Gene vanXYC encodes D,D -dipeptidase (VanX) and D,D-carboxypeptidase (VanY) activities in vancomycin-resistant Enterococcus gallinarum BM4174.

PMID 10564477 · 1999

Gene Information

Gene Name: vanXY-C
Allele: VanXY-C
Encodes: D-Ala-D-Ala dipeptidase/D-Ala-D-Ala carboxypeptidase VanXY-C
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus gallinarum
Sequence Accession: AF162694.1
Protein Accession: AAF61331.1
Notes: ARO:3002966

Gene vanXYC encodes D,D -dipeptidase (VanX) and D,D-carboxypeptidase (VanY) activities in vancomycin-resistant Enterococcus gallinarum BM4174.

PMID 10564477 · 1999

Gene Information

Gene Name: vanXY-C
Allele: VanXY-C
Encodes: D-Ala-D-Ala dipeptidase/D-Ala-D-Ala carboxypeptidase VanXY-C
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus gallinarum
Sequence Accession: AF162694.1
Protein Accession: AAF61331.1
Notes: ARO:3002966

vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174.

PMID 10817725 · 2000

The study identifies the vanC cluster in Enterococcus gallinarum BM4174, consisting of vanC-1, vanXY_C, vanT, vanR_C, and vanS_C. The genes vanC-1, vanXY_C, and vanT are necessary and sufficient for vancomycin resistance.

Gene Information

Gene Name: vanXY-C
Allele: vanXY_C
Encodes: d,d-dipeptidase-carboxypeptidase
Source Database: Reslit
Mechanism: hydrolyzes d-Ala-d-Ala and removes d-Ala from UDP-MurNAc-pentapeptide[d-Ala]
Confers Resistance To: glycopeptides
Organisms Tested In: • Enterococcus gallinarum BM4174
• Escherichia coli
Validation Method: cloning and MIC testing
Sequence Accession: AF162694

Biochemical and genetic characterization of the vanC-2 vancomycin resistance gene cluster of Enterococcus casseliflavus ATCC 25788.

PMID 12234834 · 2002

The study characterizes the vanC-2 gene cluster in Enterococcus casseliflavus ATCC 25788, identifying genes involved in vancomycin resistance, including vanC-2, vanXY C-2, vanT C-2, vanR C-2, and vanS C-2. These genes contribute to the production of cell wall precursors that replace d-alanine with d-serine, reducing vancomycin binding.

Gene Information

Gene Name: vanXY-C
Allele: vanXY C-2
Encodes: d,d-dipeptidase-d,d-carboxypeptidase
Source Database: Reslit
Confers Resistance To: vancomycin
Organisms Tested In: • Enterococcus casseliflavus ATCC 25788
Validation Method: cloning and enzymatic activity assays
Sequence Accession: AY033089

Biochemical and genetic characterization of the vanC-2 vancomycin resistance gene cluster of Enterococcus casseliflavus ATCC 25788.

PMID 12234834 · 2002

Gene Information

Gene Name: vanXY-C
Allele: VanXY-C
Encodes: D-Ala-D-Ala dipeptidase/D-Ala-D-Ala carboxypeptidase VanXY-C
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus casseliflavus
Sequence Accession: AY033089.1
Protein Accession: AAK53979.1

The vanC-3 vancomycin resistance gene cluster of Enterococcus flavescens CCM 439.

PMID 12615874 · 2003

Gene Information

Gene Name: vanXY-C
Allele: VanXY-C
Encodes: D-Ala-D-Ala dipeptidase/D-Ala-D-Ala carboxypeptidase VanXY-C
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus casseliflavus
Sequence Accession: AY033764.1
Protein Accession: AAK58490.1

Transcriptional analysis of the vanC cluster from Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance.

PMID 15728903 · 2005

The study characterizes the vanC cluster in Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance, identifying key genes and mutations involved in glycopeptide resistance mechanisms.