Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
dd-carboxypeptidase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| vanY | Reslit | 19 | glycopeptides, vancomycin +1 | Enterococcus faecium BM4339 +17 | Ontario, Venezuela, British Columbia, Canada|British Columbia, Brazil, Egypt, South Africa, Bangladesh, Mayurbhanj, Odisha, India|India, China, Europe | 1993, 1997, 1999, 2001, 2010, 2015, 2016, 2020, 2021, 2023, 2024, 2025 | AF130997|AF130998 | - |
| VanY | Reslit | 2 | vancomycin, glycopeptides | Clostridium acidurici 9a +1 | Bangladesh | 2012, 2025 | CP003326|CP003327 | - |
| vanYA | Reslit | 2 | vancomycin, glycopeptides | Staphylococcus aureus +2 | - | 2015, 2021 | - | - |
| VanY-A | Card DatabaseReference Gene CatalogReslit | 5 | vancomycin, teicoplanin +1 | Enterococcus faecium +2 | Brazil, Chettia Chlef Hospital | 1995, 1998, 2022, 2023 | QHLB00000000|MXAT00000000|QHLC00000000|QNUP00000000|MVGF00000000|MVGH00000000|QNUQ00000000|QHLD00000000|MVGJ00000000 | AAA65958.1 |
| van(Y) | Reslit | 1 | glycopeptides | Limosilactobacillus petauri | Europe | 2025 | CP089115|CP089116|CP089117|CP089118 | - |
Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.
The study characterizes the vanD glycopeptide resistance gene cluster in Enterococcus faecium BM4339, identifying several genes including vanD, vanH, vanX, vanY, vanR, and vanS, which collectively confer resistance to glycopeptide antibiotics through the synthesis of d-alanyl-d-lactate-terminating peptidoglycan precursors.
Regulation of Expression of the vanD Glycopeptide Resistance Gene Cluster from Enterococcus faecium BM4339.
The study identifies and characterizes the vanD glycopeptide resistance gene cluster in Enterococcus faecium BM4339, including the genes vanD, vanX, vanY, vanH, intD, vanR, and vanS, which are involved in the resistance mechanism against glycopeptide antibiotics.
Novel mechanism of glycopeptide resistance in the A40926 producer Nonomuraea sp. ATCC 39727.
The study identified vanY as a gene involved in glycopeptide resistance in Nonomuraea sp. ATCC 39727, demonstrating that the gene's d,d-carboxypeptidase activity contributes to resistance by modifying peptidoglycan precursors.
The purine-utilizing bacterium Clostridium acidurici 9a: a genome-guided metabolic reconsideration.
The study identifies genes in Clostridium acidurici 9a that confer resistance to bacitracin, acriflavine, and azaleucine.
Thirty-minute screening of antibiotic resistance genes in bacterial isolates with minimal sample preparation in static self-dispensing 64 and 384 assay cards.
The study presents a rapid LAMP-based method for detecting antibiotic resistance genes in bacterial isolates with minimal sample preparation, demonstrating successful detection of various resistance genes including aadD, bacA, ble, mepA, norA, qacA, and tetM.
Vancomycin-Variable Enterococcal Bacteremia
The study reports a case of vancomycin-variable Enterococcus (VVE) bacteremia, highlighting the challenges in diagnosing and treating VVE due to its ability to develop resistance to vancomycin despite initial susceptibility. The VVE isolates were found to possess the vanA gene, which is responsible for vancomycin resistance.
Chlorhexidine Induces VanA-Type Vancomycin Resistance Genes in Enterococci.
Chlorhexidine induces the expression of VanA-type vancomycin resistance genes in Enterococcus faecium and Enterococcus faecalis, including vanH, vanA, vanX, vanY, and vanZ, which are part of the vancomycin resistance gene cluster.
Molecular Characterization and Antimicrobial Susceptibilities of Nocardia Species Isolated from the Soil; A Comparison with Species Isolated from Humans.
The study identified various antimicrobial resistance genes in Nocardia species isolated from soil, including beta-lactamase, aminoglycoside modifying enzymes, macrolide resistance genes, chloramphenicol resistance proteins, vancomycin resistance, and multidrug efflux pumps. Some soil N. cyriacigeorgica strains exhibited distinct genetic profiles suggesting possible new subspecies or species.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
Effect of Vancomycin on Cytoplasmic Peptidoglycan Intermediates and van Operon mRNA Levels in VanA-Type Vancomycin-Resistant Enterococcus faecium.
The study characterizes the VanA-type vancomycin resistance mechanism in Enterococcus faecium, highlighting the role of the van operon genes (vanA, vanH, vanX, vanY, vanR, vanS) in replacing D-Ala-D-Ala with D-Ala-D-Lac in peptidoglycan, leading to vancomycin resistance.
Genetic description of VanD phenotype vanA genotype in vancomycin-resistant Enterococcus faecium isolates from a Bone Marrow Transplantation Unit.
The study characterizes the genetic structure of vancomycin-resistant Enterococcus faecium isolates displaying a VanD phenotype with a vanA genotype, highlighting the presence of various resistance genes and genetic variations within the van transposon.
Genomics of Tenacibaculum Species in British Columbia, Canada.
The study identified tetracycline resistance genes (tetQ, tetR) and vancomycin resistance genes (vanT, vanX, vanY) in various Tenacibaculum species isolated from Atlantic salmon in British Columbia, Canada.
Brevundimonas brasiliensis sp. nov.: a New Multidrug-Resistant Species Isolated from a Patient in Brazil.
The study characterizes Brevundimonas brasiliensis sp. nov., a novel species isolated from a neonatal intensive care unit, and identifies several antimicrobial resistance genes and mutations associated with resistance to β-lactams, aminoglycosides, fluoroquinolones, and colistin.
Safety assessment of Enterococcus lactis strains complemented with comparative genomics analysis reveals probiotic and safety characteristics of the entire species.
The study found that the two E. lactis strains 10NA and 50NA showed resistance to bile salts and acid tolerance with antibacterial activity against several pathogens. They were sensitive to vancomycin, tetracycline, and chloramphenicol. Whole-genome analysis revealed no transferable antibiotic resistance genes, confirming the safety of the E. lactis species.
Draft genome sequencing data of Enterococcus faecium BT22, a vancomycin-resistant opportunistic pathogen isolated from hospital effluents.
The study identified 12 antibiotic resistance genes and one virulence gene in strain BT22, including genes conferring resistance to aminoglycosides, macrolides, tetracyclines, and vancomycin.
Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen.
The study identified multiple antibiotic resistance genes in coagulase-negative staphylococci (CoNS) isolates from acne patients in Egypt, including blaZ, mecA, tet(K), erm(C), lnuA, vgaA, dfrC, fusB, fosBx1, norA, and vanT. These genes were found to be located on plasmids and chromosomes, indicating a multidrug-resistant profile.
Genomic diversity, antibiotic resistance, and virulence in South African Enterococcus faecalis and Enterococcus lactis isolates.
The study identifies several antibiotic resistance genes in South African Enterococcus faecalis and Enterococcus lactis isolates, including dfrE, vanW, vanT, efrA, tet(M), AAC(6')-Ii, msrC, and vanY, which confer resistance to trimethoprim, glycopeptides, tetracycline, macrolides, and aminoglycosides.
Comprehensive genomic analysis reveals virulence and antibiotic resistance genes in a multidrug-resistant Bacillus cereus isolated from hospital wastewater in Bangladesh.
The study identified several AMR genes in a multidrug-resistant Bacillus cereus strain isolated from hospital wastewater, including beta-lactamases (BcII, BcIII, BcI), glycopeptide resistance genes (vanW, vanY, vanT), tetracycline resistance gene (tetB(P)), fosfomycin resistance gene (fosB), and efflux pump genes (bcrA, bcrB, ykkCD, qacJ).
Comprehensive genomic analysis reveals virulence and antibiotic resistance genes in a multidrug-resistant Bacillus cereus isolated from hospital wastewater in Bangladesh.
The study identified several AMR genes in a multidrug-resistant Bacillus cereus strain isolated from hospital wastewater, including beta-lactamases (BcII, BcIII, BcI), glycopeptide resistance genes (vanW, vanY, vanT), tetracycline resistance gene (tetB(P)), fosfomycin resistance gene (fosB), and efflux pump genes (bcrA, bcrB, ykkCD, qacJ).
Unveiling community structure, antimicrobial resistance, and virulence factor of a wastewater sample of dairy farm located in mayurbhanj, odisha, india.
The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Lignocellulose degradation capabilities and distribution of antibiotic resistance genes and virulence factors in Clostridium from the gut of giant pandas.
The study identified 19 antibiotic resistance genes (ARGs) in Clostridium species from the gut of giant pandas, including glycopeptide resistance genes (vanG, vanH, vanR, vanT, vanW, vanX, vanY), tetracycline resistance genes (tet(Q), tetA(P), tetB(P)), multidrug resistance genes (cplR, sdrM, ermQ), and disinfectant resistance genes (qacG, qacJ).
Whole-genome analysis of Lysinibacillus boronitolerans MSR1: A dairy-isolated multidrug-resistant and non-pathogenic strain.
The study identifies several antimicrobial resistance (AMR) genes in Lysinibacillus boronitolerans MSR1, including qacJ, vanW, vanT, and FosBx1, which confer resistance to disinfectants, vancomycin, and fosfomycin.
Plasmid-Mediated Spread of Antibiotic Resistance by Arsenic and Microplastics During Vermicomposting.
Arsenic and microplastics significantly influenced the spread of antibiotic resistance genes (ARGs) during vermicomposting, with specific genes like bla ampC, bla LRA-1, bla FEZ-1, aph(3′)-II, ermB, vanY, mefA, catA, tetX4, bla IMP-11, aadK, ant(3′)-Ih-aac(6′)-Id, ermG, bla OXA-119, tetR, vatE, smeE, mexD, bla OXA-3, amrB, tetY, class A beta-lactamase, dfrA1, alanine adenosyltransferase JOHN-1, mdtB, mdtE, and erm-41 being enriched under various treatment conditions.
Genomic and Phenotypic Landscape of Antibiotic Resistance in Gut Lactic Acid Bacteria from Livestock Environments.
The study identified multiple antibiotic resistance genes in lactic acid bacteria (LAB) from livestock environments, including van(T), erm(B), cat(A), tet(W), lsa(D), arr, van(Y), and qac(G). These genes conferred resistance to various antibiotics, highlighting the potential for horizontal gene transfer and the importance of monitoring LAB for AMR.
The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin.
The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin.
Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.
The study characterizes Tn1546, a transposon responsible for glycopeptide resistance in Enterococcus faecium BM4147, through the biosynthesis of depsipeptide peptidoglycan precursors involving genes vanA, vanH, and vanY.
Vancomycin-resistant enterococci.
The study characterizes the vanA gene cluster responsible for vancomycin resistance in enterococci, detailing its mechanism of action through the synthesis of D-alanine-D-lactate, which prevents vancomycin from binding to cell wall precursors.
vanA gene cluster in a vancomycin-resistant clinical isolate of Bacillus circulans.
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